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Conserved domains on  [gi|2513212479|gb|WIF29584|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Paraechinus hypomelas]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.27e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.50  E-value: 2.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.27e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.50  E-value: 2.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.14e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 66.05  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  3 IMYMNVMLAFMIALIGtLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMF 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 2513212479 83 NYYGNDYVQNLNLLKC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-97 5.70e-07

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 43.51  E-value: 5.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479 12 FMIALIGTLIyRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMFNYYGNDYVQ 91
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*.
gi 2513212479 92 NLNLLK 97
Cdd:COG0713   93 DLNELK 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.27e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.50  E-value: 2.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 1.50e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 86.17  E-value: 1.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479 11 AFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMFNYYGNDYV 90
Cdd:MTH00126  11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                 ....*...
gi 2513212479 91 QNLNLLKC 98
Cdd:MTH00126  91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.59e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 84.13  E-value: 9.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.68e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 79.65  E-value: 5.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.14e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 66.05  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  3 IMYMNVMLAFMIALIGtLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMF 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 2513212479 83 NYYGNDYVQNLNLLKC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 9.46e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 58.42  E-value: 9.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  4 MYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMFN 83
Cdd:MTH00181   1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                         90
                 ....*....|...
gi 2513212479 84 YYGNDYVQNLNLL 96
Cdd:MTH00181  81 THGSDHLLKFNLL 93
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.59e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 50.61  E-value: 9.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLslVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00149   2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMM--FSSSGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00149  80 LIRLHGNDYVSSLSSLKF 97
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 6.54e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 48.76  E-value: 6.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVK 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 2513212479 81 MFNYYGNDYVQNLNLLK 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 4-98 8.24e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 48.43  E-value: 8.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  4 MYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMipLIILVFAACEAALGLALLVKMFN 83
Cdd:MTH00188   5 MILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLS--LVLLTFAACEASVGLALLVSLIR 82

                         90
                 ....*....|....*
gi 2513212479 84 YYGNDYVQNLNLLKC 98
Cdd:MTH00188  83 SHGSDYVSSLNLIKC 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.07e-07

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 45.51  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  1 MSIMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIpLIILVFAACEAALGLALLVK 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGMLA-IVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 2513212479 81 MFNYYGNDYVQNLNLLKC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-92 1.11e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 45.15  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  3 IMYMNVMLAFMIALIGTLIYRHHLMSSLLCLEGMMLatYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMF 82
Cdd:MTH00162   2 MMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVL--SLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMI 79

                         90
                 ....*....|
gi 2513212479 83 NYYGNDYVQN 92
Cdd:MTH00162  80 RSHGNDYFSS 89
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-97 5.70e-07

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 43.51  E-value: 5.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479 12 FMIALIGTLIyRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMFNYYGNDYVQ 91
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*.
gi 2513212479 92 NLNLLK 97
Cdd:COG0713   93 DLNELK 98
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
12-97 4.19e-04

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 36.31  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  12 FMIALIGTLIYRHHLMSsLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMFNYYGNDYVQ 91
Cdd:PRK05715   15 FCIGLVGLLLRRNAIVV-LMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAILLQLYRNRGTIDVD 93


                  ....*.
gi 2513212479  92 NLNLLK 97
Cdd:PRK05715   94 DLNELK 99
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 8-97 5.63e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 33.11  E-value: 5.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2513212479  8 VMLAFMIALIGTLIYRHHLMSSLLCLEGMMLATYIFLSLVSLNMHFTTTYMIPLIILVFAACEAALGLALLVKMFNYYGN 87
Cdd:MTH00001   9 VVILFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGT 88

                         90
                 ....*....|
gi 2513212479 88 DYVQNLNLLK 97
Cdd:MTH00001  89 ISLKSLNSLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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