NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2557276830|gb|WLD06932|]
View 

NADH dehydrogenase subunit 2, partial (mitochondrion) [Mixophyes hihihorlo]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl31790
NADH dehydrogenase subunit 2; Provisional
 1-159 6.61e-84

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00070:

Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 250.22  E-value: 6.61e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00070    1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00070   81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGL 159
 
Name Accession Description Interval E-value
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-159 6.61e-84

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 250.22  E-value: 6.61e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00070    1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00070   81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGL 159
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 7-145 4.05e-12

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 62.83  E-value: 4.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   7 FVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPL--MTKTpHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEW 84
Cdd:COG1007   105 YALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLvaFRRD-DRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSL 183

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2557276830  85 AINNFSNPVTTTT-----LTIALVM-------KLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQL 145
Cdd:COG1007   184 NLAGIAAALAAGGansplLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRL 256
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-142 1.52e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 55.01  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  23 SHHWLLAWMGLEINTLAVIPLMT-KTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEWAINNFSNPVTTTT---- 97
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLnssg 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2557276830  98 -------LTIALVMKLGLAPFHFWLPEVLQGISLTTGLIL-STWQKLAPMALL 142
Cdd:pfam00361  81 llllfllILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLI 133
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 23-149 2.42e-09

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 54.57  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  23 SHHWLLAWMGLEINTLAVIPLMT-KTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEWAINNFSNPVTTTTLTI- 100
Cdd:TIGR01770 121 SNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLNFEDLLLFLSNGMLNIs 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830 101 -----------ALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSI 149
Cdd:TIGR01770 201 llllgivlilvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYI 260
 
Name Accession Description Interval E-value
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-159 6.61e-84

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 250.22  E-value: 6.61e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00070    1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00070   81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGL 159
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-159 2.51e-77

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 233.54  E-value: 2.51e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00135    1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSiNLTLLMTIGI 159
Cdd:MTH00135   81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGL 158
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-159 3.46e-69

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 212.76  E-value: 3.46e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00112    1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00112   81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAI 159
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-159 2.07e-68

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 210.47  E-value: 2.07e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00105    1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00105   81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAI 159
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-159 2.53e-52

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 169.38  E-value: 2.53e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00200    1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00200   81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGL 159
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-159 1.50e-49

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 162.41  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00041    1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 TGEWAINNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIGI 159
Cdd:MTH00041   81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGI 159
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-159 5.64e-29

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 108.37  E-value: 5.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   1 MNPHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWL 80
Cdd:MTH00160    2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  81 tgewaiNNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALliqLSPSINLTLLMTIGI 159
Cdd:MTH00160   82 ------LMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLIL---LSYLINNNFIIIIII 151
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 5-155 2.18e-28

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 106.51  E-value: 2.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   5 ALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEW 84
Cdd:MTH00144    5 SNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSW 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2557276830  85 AINNFsnpvttttLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLM 155
Cdd:MTH00144   85 FSMSL--------LLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLL 147
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 6-158 7.16e-24

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 94.85  E-value: 7.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   6 LFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNawltgeWA 85
Cdd:MTH00011    8 MFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMM------WS 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2557276830  86 INNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTIG 158
Cdd:MTH00011   82 FPSLLKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMA 154
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 7-148 1.50e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 82.80  E-value: 1.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   7 FVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAwltgewaI 86
Cdd:MTH00197    1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSF-------S 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2557276830  87 NNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPS 148
Cdd:MTH00197   74 NLYLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSS 135
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 6-157 4.16e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 68.50  E-value: 4.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   6 LFVIISSLaagtittLL--SHHWLLAWMGLEINTLAV-IPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTG 82
Cdd:MTH00199  104 LIVALGSL-------LLvsSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTG 176

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  83 EWAI----NNFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTI 157
Cdd:MTH00199  177 ETSIqginSILTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAV 255
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-157 4.63e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 65.44  E-value: 4.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  13 LAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHP-RAIEAATKYFLTQAAASAMILFSSTLNAWLTGEWAIN---- 87
Cdd:MTH00196    2 VALGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSgYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHLSyinl 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2557276830  88 ---------NFSNPVTTTTLTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLMTI 157
Cdd:MTH00196   82 vlnsgqsfsSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGL 160
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 7-145 4.05e-12

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 62.83  E-value: 4.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   7 FVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPL--MTKTpHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEW 84
Cdd:COG1007   105 YALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLvaFRRD-DRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSL 183

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2557276830  85 AINNFSNPVTTTT-----LTIALVM-------KLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQL 145
Cdd:COG1007   184 NLAGIAAALAAGGansplLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRL 256
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-142 1.52e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 55.01  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  23 SHHWLLAWMGLEINTLAVIPLMT-KTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEWAINNFSNPVTTTT---- 97
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLnssg 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2557276830  98 -------LTIALVMKLGLAPFHFWLPEVLQGISLTTGLIL-STWQKLAPMALL 142
Cdd:pfam00361  81 llllfllILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLI 133
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 23-149 2.42e-09

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 54.57  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  23 SHHWLLAWMGLEINTLAVIPLMT-KTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEWAINNFSNPVTTTTLTI- 100
Cdd:TIGR01770 121 SNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLNFEDLLLFLSNGMLNIs 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830 101 -----------ALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSI 149
Cdd:TIGR01770 201 llllgivlilvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYI 260
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
23-145 2.52e-08

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 51.75  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  23 SHHWLLAWMGLEINTLAVIPL-MTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTG-----EWAINNFSNPVTTT 96
Cdd:PRK05777  122 ANDLLTLFLGLELLSLPLYALaALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLYGATGslsfaGIAKALADGSGNSL 201

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2557276830  97 TLTIALVM-------KLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQL 145
Cdd:PRK05777  202 LLLFGLVFllvglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRL 257
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 3-159 3.60e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 48.32  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830   3 PHALFVIISSLAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAI---------EAATKYFLTQAAASAMILFS 73
Cdd:MTH00198  187 PRSGFALVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFG 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  74 STLNAWLTG-EWAINNFSNPVTTTT-------------LTIALVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPM 139
Cdd:MTH00198  267 CALYFGFTGnEGMLGTILSATLETTnielrqgslgylfITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVY 346

                         170       180
                  ....*....|....*....|
gi 2557276830 140 ALLIQLspSINLTLLMTIGI 159
Cdd:MTH00198  347 ILLTSL--VITSKLLLSVAI 364
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 13-116 1.41e-05

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 43.60  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  13 LAAGTITTLLSHHWLLAWMGLEINTLAVIPLMTKTPHPRAIEAATKYFLTQAAASAMILFSSTLNAWLTGEW-------A 85
Cdd:COG0651   116 LLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLnmadlaaR 195

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2557276830  86 INNFSNPVTTTTLTIALV---MKLGLAPFHFWLP 116
Cdd:COG0651   196 LAELDPGLLLAAFALLLVgfgIKAALFPLHFWLP 229
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
50-145 2.74e-05

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 43.12  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  50 PRAIEAATKYFLTQAAASAMILFSSTLNAWLT-GEWAINNFSNPVTTTT---LTIALVM-------KLGLAPFHFWLPEV 118
Cdd:PRK02504  157 PRSNEAALKYLLIGAASSAIFLYGSSLLYGLSgGSTQLSAIALALITSPslgLALALVFviagiafKISAVPFHQWTPDV 236

                          90       100
                  ....*....|....*....|....*..
gi 2557276830 119 LQGISLTTGLILSTWQKLAPMALLIQL 145
Cdd:PRK02504  237 YEGSPTPVVAFLSVGSKAAGFALAIRL 263
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 33-117 7.79e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 38.54  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  33 LEINTLAVIPLMT-KTPHPRAIEAATKYFLTQAAASAMILFSSTL-----NAWLTGEWAINNFSNPVTTTT-----LTIA 101
Cdd:PRK08376  150 LEIMSIASYALVAfRNDTWEAIEAGIKYMFVGSLASSMVLLGIALlygqyGTLNMAYLAVKMSENPTVVAKialalFIAG 229

                          90
                  ....*....|....*.
gi 2557276830 102 LVMKLGLAPFHFWLPE 117
Cdd:PRK08376  230 LAMKSGAVPVHMWLPD 245
ndhB CHL00049
NADH dehydrogenase subunit 2
 51-145 8.31e-03

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 35.75  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2557276830  51 RAIEAATKYFLTQAAASAMILFSSTLNAWLTGE----WAINN---FSNPVTTTTLTIALV-------MKLGLAPFHFWLP 116
Cdd:CHL00049  159 RSNEATMKYLLMGGASSSILVYGFSWLYGLSGGeielQEIVNgliNTQMYNSPGISIALIfitvgigFKLSLAPFHQWTP 238

                          90       100
                  ....*....|....*....|....*....
gi 2557276830 117 EVLQGISLTTGLILSTWQKLAPMALLIQL 145
Cdd:CHL00049  239 DVYEGSPTPVVAFLSVTSKVAASALATRI 267
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 102-155 8.53e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 35.23  E-value: 8.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2557276830 102 LVMKLGLAPFHFWLPEVLQGISLTTGLILSTWQKLAPMALLIQLSPSINLTLLM 155
Cdd:MTH00091   67 LMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH