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Conserved domains on  [gi|2568048044|gb|WMF21253.1|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Eutropis multifasciata]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
1-73 8.75e-23

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00135:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 347  Bit Score: 89.09  E-value: 8.75e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMTA 73
Cdd:MTH00135  169 LNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTA 241
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
1-73 8.75e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 89.09  E-value: 8.75e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMTA 73
Cdd:MTH00135  169 LNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTA 241
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
1-73 8.75e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 89.09  E-value: 8.75e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMTA 73
Cdd:MTH00135  169 LNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTA 241
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
1-73 1.20e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 86.03  E-value: 1.20e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMTA 73
Cdd:MTH00112  170 LNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNT 242
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-72 1.70e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 82.97  E-value: 1.70e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMT 72
Cdd:MTH00105  170 LNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMT 241
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
1-73 5.90e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 81.51  E-value: 5.90e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMTA 73
Cdd:MTH00070  170 LNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTS 242
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
1-69 1.09e-14

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 66.88  E-value: 1.09e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISP 69
Cdd:MTH00041  170 LNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNP 238
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
1-72 4.21e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 59.60  E-value: 4.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMT 72
Cdd:MTH00200  170 LNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILS 241
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
1-63 2.06e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 46.42  E-value: 2.06e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTT 63
Cdd:MTH00144  163 LNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGS 225
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
1-73 6.50e-07

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 45.16  E-value: 6.50e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQMTA 73
Cdd:MTH00011  166 MNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSM 238
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
1-71 9.26e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 41.73  E-value: 9.26e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIKDLTTAWSISPQM 71
Cdd:MTH00160  162 LNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
1-59 3.17e-05

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 40.04  E-value: 3.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2568048044   1 LNQTQTRKIMAFSSI*HLGWMASILTLNPNIMLLNLILYIIMTTPMFMMLMFTSSKTIK 59
Cdd:MTH00197  155 MNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLN 213
 
Blast search parameters
Data Source: Live blast search RID = KUX2B2EJ016
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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