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Conserved domains on  [gi|2577523089|gb|WNB50819|]
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Toll-like receptor 3, partial [Pyrrhula pyrrhula]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 48-331 2.32e-10

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  48 SRLFYGLSSLKYLNLI-NSLTGKIEDFSFHWLYHLEYLIMDNNNFPG--------------ITANMFTG--------LNN 104
Cdd:PLN00113   86 SSAIFRLPYIQTINLSnNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGsiprgsipnletldLSNNMLSGeipndigsFSS 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 105 LKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSLGHLKILDLGLNEISQQLTgHEFKGLNNIQ 183
Cdd:PLN00113  166 LKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP-YEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 184 DIYLSYNKKLTLQSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQH 263
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFS 317

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 264 NNLARLWKHAnpdgpvlfLKGLSNLQILNLKSNGLD-EIPVQVFKGlFQLKHLDLGSNNLN-LLPATLFD 331
Cdd:PLN00113  318 NNFTGKIPVA--------LTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTgEIPEGLCS 378
LRR_8 pfam13855
Leucine rich repeat;
8-62 3.28e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2577523089   8 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKINNI-HVSSRLFYGLSSLKYLNL 62
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLtTLSPGAFSGLPSLRYLDL 56
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-331 2.32e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  48 SRLFYGLSSLKYLNLI-NSLTGKIEDFSFHWLYHLEYLIMDNNNFPG--------------ITANMFTG--------LNN 104
Cdd:PLN00113   86 SSAIFRLPYIQTINLSnNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGsiprgsipnletldLSNNMLSGeipndigsFSS 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 105 LKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSLGHLKILDLGLNEISQQLTgHEFKGLNNIQ 183
Cdd:PLN00113  166 LKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP-YEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 184 DIYLSYNKKLTLQSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQH 263
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFS 317

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 264 NNLARLWKHAnpdgpvlfLKGLSNLQILNLKSNGLD-EIPVQVFKGlFQLKHLDLGSNNLN-LLPATLFD 331
Cdd:PLN00113  318 NNFTGKIPVA--------LTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTgEIPEGLCS 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-326 4.47e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  47 SSRLFYGLSSLKYLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQRITNKTFS 126
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 127 SLANSSLQVLNLTKTRIStiESGAFSSLGHLKILDLGLNEISQqlTGHEFKGLNNIQDIYLSYNKkLTLQSESFIFVPSL 206
Cdd:COG4886    87 LGLTDLGDLTNLTELDLS--GNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LTDLPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 207 RKLMLRKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKEDLFdGLDKLDILDLQHNNLARLwkhanpdgpVLFLKGLS 286
Cdd:COG4886   162 KSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDL---------PEPLANLT 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2577523089 287 NLQILNLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLP 326
Cdd:COG4886   229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP 266
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 116-296 9.13e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 9.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 116 NLQRITNktFSSLANssLQVLNLTKTRISTIESgaFSSLGHLKILDLGLNEISQqLTGHEfkGLNNIQDIYLSYNKklTL 195
Cdd:cd21340    35 KITKIEN--LEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISV-VEGLE--NLTNLEELHIENQR--LP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 196 QSESFIFVPslrklmlrkvgCSNLALSPSpfhplrnLTVLDISNNNIANIKEdlFDGLDKLDILDLQHNNLARLwkhanp 275
Cdd:cd21340   104 PGEKLTFDP-----------RSLAALSNS-------LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL------ 157

                         170       180
                  ....*....|....*....|.
gi 2577523089 276 DGPVLFLKGLSNLQILNLKSN 296
Cdd:cd21340   158 EELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
8-62 3.28e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2577523089   8 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKINNI-HVSSRLFYGLSSLKYLNL 62
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLtTLSPGAFSGLPSLRYLDL 56
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 6-127 6.95e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 47.54  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089   6 QGTNLTILNLSqNSLSVIENDSFQWLSSLQYLNLKINNIHVSSRLFYGlSSLKYLNLINSLTgKIEDFSFHWLYHLEYLI 85
Cdd:pfam13306   9 YNCSLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSSLTSIGSYAFYN-CSLTSITIPSSLT-SIGEYAFSNCSNLKSIT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2577523089  86 MdNNNFPGITANMFTGlNNLKYLSLCNcniNLQRITNKTFSS 127
Cdd:pfam13306  86 L-PSNLTSIGSYAFSN-CSLKSITIPS---SVTTIGSYAFSN 122
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-331 2.32e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  48 SRLFYGLSSLKYLNLI-NSLTGKIEDFSFHWLYHLEYLIMDNNNFPG--------------ITANMFTG--------LNN 104
Cdd:PLN00113   86 SSAIFRLPYIQTINLSnNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGsiprgsipnletldLSNNMLSGeipndigsFSS 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 105 LKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSLGHLKILDLGLNEISQQLTgHEFKGLNNIQ 183
Cdd:PLN00113  166 LKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP-YEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 184 DIYLSYNKKLTLQSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQH 263
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFS 317

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 264 NNLARLWKHAnpdgpvlfLKGLSNLQILNLKSNGLD-EIPVQVFKGlFQLKHLDLGSNNLN-LLPATLFD 331
Cdd:PLN00113  318 NNFTGKIPVA--------LTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTgEIPEGLCS 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-326 4.47e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  47 SSRLFYGLSSLKYLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQRITNKTFS 126
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 127 SLANSSLQVLNLTKTRIStiESGAFSSLGHLKILDLGLNEISQqlTGHEFKGLNNIQDIYLSYNKkLTLQSESFIFVPSL 206
Cdd:COG4886    87 LGLTDLGDLTNLTELDLS--GNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LTDLPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 207 RKLMLRKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKEDLFdGLDKLDILDLQHNNLARLwkhanpdgpVLFLKGLS 286
Cdd:COG4886   162 KSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDL---------PEPLANLT 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2577523089 287 NLQILNLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLP 326
Cdd:COG4886   229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP 266
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 116-296 9.13e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 9.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 116 NLQRITNktFSSLANssLQVLNLTKTRISTIESgaFSSLGHLKILDLGLNEISQqLTGHEfkGLNNIQDIYLSYNKklTL 195
Cdd:cd21340    35 KITKIEN--LEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISV-VEGLE--NLTNLEELHIENQR--LP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 196 QSESFIFVPslrklmlrkvgCSNLALSPSpfhplrnLTVLDISNNNIANIKEdlFDGLDKLDILDLQHNNLARLwkhanp 275
Cdd:cd21340   104 PGEKLTFDP-----------RSLAALSNS-------LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL------ 157

                         170       180
                  ....*....|....*....|.
gi 2577523089 276 DGPVLFLKGLSNLQILNLKSN 296
Cdd:cd21340   158 EELLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-325 1.08e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089   8 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKINNIHVSSRLFYGLSSLKYLNLINSLTGKIEDFSFHWLYHLEYLIMD 87
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  88 NNNFPGITANMFTGLNNLKYLSLCNcninlqritNKTFSSLANssLQVLNLTKTRISTIESgAFSSLGHLKILDLGLNEI 167
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSG---------NEELSNLTN--LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 168 SQqlTGHEFKGLNNIQDIYLSYNkKLTLQSESFIFVPSLRKLMLRKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKE 247
Cdd:COG4886   149 TD--LPEPLGNLTNLKSLDLSNN-QLTDLPEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPE 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2577523089 248 DLfDGLDKLDILDLQHNNLARLwkhanpdgpvLFLKGLSNLQILNLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLL 325
Cdd:COG4886   223 PL-ANLTNLETLDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
8-62 3.28e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2577523089   8 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKINNI-HVSSRLFYGLSSLKYLNL 62
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLtTLSPGAFSGLPSLRYLDL 56
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 8-322 6.07e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 6.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089   8 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKINNIhvSSRLFY---GLSSLKYLNLI-NSLTGKIEDfSFHWLYHLEY 83
Cdd:PLN00113  188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL--SGEIPYeigGLTSLNHLDLVyNNLTGPIPS-SLGNLKNLQY 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  84 LIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQriTNKTFSSLANssLQVLNLTKTRISTIESGAFSSLGHLKILDLG 163
Cdd:PLN00113  265 LFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGE--IPELVIQLQN--LEILHLFSNNFTGKIPVALTSLPRLQVLQLW 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 164 LNEISQQLTGHEFKGlNNIQDIYLSYNK----------------KLTLQSESF--IFVPSLRKLM-LRKVGCSNLALS-- 222
Cdd:PLN00113  341 SNKFSGEIPKNLGKH-NNLTVLDLSTNNltgeipeglcssgnlfKLILFSNSLegEIPKSLGACRsLRRVRLQDNSFSge 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 223 -PSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNLArlwkhanpdGPVLFLKGLSNLQILNLKSNGLDEI 301
Cdd:PLN00113  420 lPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF---------GGLPDSFGSKRLENLDLSRNQFSGA 490

                         330       340
                  ....*....|....*....|.
gi 2577523089 302 PVQVFKGLFQLKHLDLGSNNL 322
Cdd:PLN00113  491 VPRKLGSLSELMQLKLSENKL 511
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 6-127 6.95e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 47.54  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089   6 QGTNLTILNLSqNSLSVIENDSFQWLSSLQYLNLKINNIHVSSRLFYGlSSLKYLNLINSLTgKIEDFSFHWLYHLEYLI 85
Cdd:pfam13306   9 YNCSLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSSLTSIGSYAFYN-CSLTSITIPSSLT-SIGEYAFSNCSNLKSIT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2577523089  86 MdNNNFPGITANMFTGlNNLKYLSLCNcniNLQRITNKTFSS 127
Cdd:pfam13306  86 L-PSNLTSIGSYAFSN-CSLKSITIPS---SVTTIGSYAFSN 122
LRR_8 pfam13855
Leucine rich repeat;
131-191 1.11e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2577523089 131 SSLQVLNLTKTRISTIESGAFSSLGHLKILDLGLNEISqQLTGHEFKGLNNIQDIYLSYNK 191
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
204-266 2.02e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.02e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2577523089 204 PSLRKLMLRkvgCSNL-ALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNL 266
Cdd:pfam13855   1 PNLRSLDLS---NNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 226-323 8.91e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 8.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 226 FHPLRNLTVLDISNNNIANIkEDLfDGLDKLDILDLQHNNLArlwkhanPDGPVLF----LKGLSN-LQILNLKSNGLDE 300
Cdd:cd21340    64 LENLVNLKKLYLGGNRISVV-EGL-ENLTNLEELHIENQRLP-------PGEKLTFdprsLAALSNsLRVLNISGNNIDS 134

                          90       100
                  ....*....|....*....|...
gi 2577523089 301 IpvQVFKGLFQLKHLDLGSNNLN 323
Cdd:cd21340   135 L--EPLAPLRNLEQLDASNNQIS 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-332 4.01e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  19 SLSVIENDSFQWLSSLQYLNLKINNIHVSSRLFYGLSSLKYLNL----INSLTGKIEDFSfhwlyHLEYLIMDNNNFPGI 94
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLsnnqLTDLPEPLGNLT-----NLKSLDLSNNQLTDL 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  95 TANmFTGLNNLKYLSLCNCNINlqrITNKTFSSLANssLQVLNLTKTRISTIeSGAFSSLGHLKILDLGLNEISQQltgH 174
Cdd:COG4886   175 PEE-LGNLTNLKELDLSNNQIT---DLPEPLGNLTN--LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL---P 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 175 EFKGLNNIQDIYLSYNKKLTLQSESFIfvPSLRKLMLRKVGCSNLALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLD 254
Cdd:COG4886   245 ELGNLTNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2577523089 255 KLDILDLQHNNLARLWKHANPDGPVLFLKGLSNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNLNLLPATLFDD 332
Cdd:COG4886   323 LLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR_8 pfam13855
Leucine rich repeat;
286-336 1.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2577523089 286 SNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQASL 336
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSL 51
LRR_8 pfam13855
Leucine rich repeat;
55-115 1.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2577523089  55 SSLKYLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNI 115
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
255-322 1.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2577523089 255 KLDILDLQHNNLARLWKHAnpdgpvlfLKGLSNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNL 322
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA--------FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-267 2.30e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089   8 TNLTILNLSQNSLSVIeNDSFQWLSSLQYLNLKINNIHVSSRLFYGLSSLKYLNLINSLTGKIEDfSFHWLYHLEYLIMD 87
Cdd:COG4886   159 TNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLS 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  88 NNNFPGITAnmFTGLNNLKYLSLCNCNInlqritnKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSLGHLKILDLGLNE 166
Cdd:COG4886   237 NNQLTDLPE--LGNLTNLEELDLSNNQL-------TDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 167 ISQQLTGHEFKGLNNIQDIYLSYNKKLTLQSESFIFVPSLRKLMLRKVGCSNLALSPSPFHPLRNLTVLDISNNNIANIK 246
Cdd:COG4886   308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387

                         250       260
                  ....*....|....*....|.
gi 2577523089 247 EDLFDGLDKLDILDLQHNNLA 267
Cdd:COG4886   388 TLLLLLLTTTAGVLLLTLALL 408
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 133-333 2.67e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 133 LQVLNLTKTRISTIE-SGAFSSLGH---LKILDLGLNEISQ-----QLTGHEFKGLNNIQDIYLSYNKKLTLQS---ESF 200
Cdd:cd00116    25 LQVLRLEGNTLGEEAaKALASALRPqpsLKELCLSLNETGRiprglQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 201 IFVPSLRKLMLRKVGCSNLA---LSPSPFHPLRNLTVLDISNNNIANIK-EDL---FDGLDKLDILDLQHNNLarlwkha 273
Cdd:cd00116   105 LRSSSLQELKLNNNGLGDRGlrlLAKGLKDLPPALEKLVLGRNRLEGAScEALakaLRANRDLKELNLANNGI------- 177

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2577523089 274 NPDG-PVLF--LKGLSNLQILNLKSNGLDEIPVQ----VFKGLFQLKHLDLGSNNLNLLPATLFDDQ 333
Cdd:cd00116   178 GDAGiRALAegLKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLTDAGAAALASA 244
LRR_8 pfam13855
Leucine rich repeat;
104-167 3.41e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2577523089 104 NLKYLSLCNCNInlQRITNKTFSSLanSSLQVLNLTKTRISTIESGAFSSLGHLKILDLGLNEI 167
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
1-44 9.67e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2577523089   1 TFQGLQgtNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKINNI 44
Cdd:pfam13855  20 AFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
32-91 1.68e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2577523089  32 SSLQYLNLKINNI-HVSSRLFYGLSSLKYLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNF 91
Cdd:pfam13855   1 PNLRSLDLSNNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 9-267 9.64e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089   9 NLTILNLSQNSLSVIENDSfqwLSSlqylnlkinnihvSSRLFyglsslKYLNLINSLTGKIEDfSFHWLYHLEYLIMDN 88
Cdd:PLN00113  357 NLTVLDLSTNNLTGEIPEG---LCS-------------SGNLF------KLILFSNSLEGEIPK-SLGACRSLRRVRLQD 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089  89 NNFPGITANMFTGLNNLKYLSLCNCNInLQRITNKTFSSlanSSLQVLNLTKTRISTIESGAFSSlGHLKILDLGLNEIS 168
Cdd:PLN00113  414 NSFSGELPSEFTKLPLVYFLDISNNNL-QGRINSRKWDM---PSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFS 488

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523089 169 QQLTgHEFKGLNNIQDIYLSYNKkltLQSESfifvpslrklmlrkvgcsnlalsPSPFHPLRNLTVLDISNNNIANIKED 248
Cdd:PLN00113  489 GAVP-RKLGSLSELMQLKLSENK---LSGEI-----------------------PDELSSCKKLVSLDLSHNQLSGQIPA 541

                         250
                  ....*....|....*....
gi 2577523089 249 LFDGLDKLDILDLQHNNLA 267
Cdd:PLN00113  542 SFSEMPVLSQLDLSQNQLS 560
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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