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Conserved domains on  [gi|2577523315|gb|WNB50932|]
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Toll-like receptor 4, partial [Serinus serinus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
123-256 2.98e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523315 123 SKVKQLECKKCGFDNVPAlKLSLFKELRVLRITKNRsLKNFEQKFEDLSNLEVIDLSENRLTFSrccSPQFQNCPNLKHL 202
Cdd:COG4886   136 TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEEL 210

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2577523315 203 NLSFNSYIRLTGDFINVENLLYLDFQHTTLfgpGSYPVFLSLQRLIYLDISHTK 256
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNNQ 261
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-256 2.98e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523315 123 SKVKQLECKKCGFDNVPAlKLSLFKELRVLRITKNRsLKNFEQKFEDLSNLEVIDLSENRLTFSrccSPQFQNCPNLKHL 202
Cdd:COG4886   136 TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEEL 210

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2577523315 203 NLSFNSYIRLTGDFINVENLLYLDFQHTTLfgpGSYPVFLSLQRLIYLDISHTK 256
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNNQ 261
LRR_8 pfam13855
Leucine rich repeat;
148-207 1.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2577523315 148 ELRVLRITKNRsLKNFEQK-FEDLSNLEVIDLSENRLTFSrccSPQ-FQNCPNLKHLNLSFN 207
Cdd:pfam13855   2 NLRSLDLSNNR-LTSLDDGaFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 135-207 9.44e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 9.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2577523315 135 FDnvPALKLSLFKELRVLRITKNR--SLKNFEqkfeDLSNLEVIDLSENRLTFSRCCSPQFQNCPNLKHLNLSFN 207
Cdd:cd21340   110 FD--PRSLAALSNSLRVLNISGNNidSLEPLA----PLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-256 2.98e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523315 123 SKVKQLECKKCGFDNVPAlKLSLFKELRVLRITKNRsLKNFEQKFEDLSNLEVIDLSENRLTFSrccSPQFQNCPNLKHL 202
Cdd:COG4886   136 TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEEL 210

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2577523315 203 NLSFNSYIRLTGDFINVENLLYLDFQHTTLfgpGSYPVFLSLQRLIYLDISHTK 256
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNNQ 261
LRR_8 pfam13855
Leucine rich repeat;
148-207 1.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2577523315 148 ELRVLRITKNRsLKNFEQK-FEDLSNLEVIDLSENRLTFSrccSPQ-FQNCPNLKHLNLSFN 207
Cdd:pfam13855   2 NLRSLDLSNNR-LTSLDDGaFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 135-207 9.44e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 9.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2577523315 135 FDnvPALKLSLFKELRVLRITKNR--SLKNFEqkfeDLSNLEVIDLSENRLTFSRCCSPQFQNCPNLKHLNLSFN 207
Cdd:cd21340   110 FD--PRSLAALSNSLRVLNISGNNidSLEPLA----PLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-256 1.57e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2577523315 142 KLSLFKELRVL-----RITKNRSLKNfeqkfedLSNLEVIDLSENRLTfsrcCSPQFQNCPNLKHLNLSFNSYIRLTGdF 216
Cdd:cd21340    19 NLSLCKNLKVLylydnKITKIENLEF-------LTNLTHLYLQNNQIE----KIENLENLVNLKKLYLGGNRISVVEG-L 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2577523315 217 INVENL--LYLDFQ-----HTTLFGPGSypVFLSLQRLIYLDISHTK 256
Cdd:cd21340    87 ENLTNLeeLHIENQrlppgEKLTFDPRS--LAALSNSLRVLNISGNN 131
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 172-211 2.77e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 2.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2577523315 172 NLEVIDLSENRLTFSrccsPQFQNCPNLKHLNLSFNSYIR 211
Cdd:pfam12799   2 NLEVLDLSNNQITDI----PPLAKLPNLETLDLSGNNKIT 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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