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Conserved domains on  [gi|446427869|ref|WP_000505724|]
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MULTISPECIES: 3-deoxy-7-phosphoheptulonate synthase [Streptococcus]

Protein Classification

3-deoxy-7-phosphoheptulonate synthase( domain architecture ID 10013161)

3-deoxy-7-phosphoheptulonate synthase catalyzes stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP)

EC:  2.5.1.54
Gene Ontology:  GO:0009073|GO:0003849|GO:0008652
SCOP:  4003245

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09261 PRK09261
phospho-2-dehydro-3-deoxyheptonate aldolase; Validated
 1-335 4.00e-160

phospho-2-dehydro-3-deoxyheptonate aldolase; Validated


:

Pssm-ID: 236435  Cd Length: 349  Bit Score: 451.16  E-value: 4.00e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   1 MGFHQLSDKINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKM 80
Cdd:PRK09261   8 LRIKEIKPLIPPAELKEELPLTEEAAETVARSRKEIHNILHGKDDRLLVVVGPCSIHDPKAALEYARRLAKLREELKDKL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  81 FLVMRVYTAKPRTNgDGYKGLVHHSDKLGVF------FQARKMHYDIIrETGLLTADELLYPEMLSVMDDLVSYYAIGAR 154
Cdd:PRK09261  88 EIVMRVYFEKPRTT-VGWKGLINDPDLDGSFdindglRIARKLLLDIN-ELGLPAATEFLDPITPQYIADLISWGAIGAR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 155 SVEDQGHRFISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGyhnadYRSIP 229
Cdd:PRK09261 166 TTESQVHRELASGLSCPVGFKNGTDGNIKVAIDAIIAASAPHHFLGITKDgrsaiVSTTGNPDCHVILRG-----GNKGP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 230 NYHYENLLETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWhtkIRNYVRGFLIESYLEDGRQD--KP 307
Cdd:PRK09261 241 NYDAESVAEAKERLEKAGL-PPRIMIDCSHANSGKDHKRQPEVARDVAAQIAA---GNKAIIGVMIESHLVEGNQDlpPK 316

                        330       340
                 ....*....|....*....|....*...
gi 446427869 308 DVFGKSITDPCLGWDKTEMLIRDIYNSL 335
Cdd:PRK09261 317 LVYGQSITDACIGWEDTEALLRELAEAV 344
 
Name Accession Description Interval E-value
PRK09261 PRK09261
phospho-2-dehydro-3-deoxyheptonate aldolase; Validated
 1-335 4.00e-160

phospho-2-dehydro-3-deoxyheptonate aldolase; Validated


Pssm-ID: 236435  Cd Length: 349  Bit Score: 451.16  E-value: 4.00e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   1 MGFHQLSDKINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKM 80
Cdd:PRK09261   8 LRIKEIKPLIPPAELKEELPLTEEAAETVARSRKEIHNILHGKDDRLLVVVGPCSIHDPKAALEYARRLAKLREELKDKL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  81 FLVMRVYTAKPRTNgDGYKGLVHHSDKLGVF------FQARKMHYDIIrETGLLTADELLYPEMLSVMDDLVSYYAIGAR 154
Cdd:PRK09261  88 EIVMRVYFEKPRTT-VGWKGLINDPDLDGSFdindglRIARKLLLDIN-ELGLPAATEFLDPITPQYIADLISWGAIGAR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 155 SVEDQGHRFISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGyhnadYRSIP 229
Cdd:PRK09261 166 TTESQVHRELASGLSCPVGFKNGTDGNIKVAIDAIIAASAPHHFLGITKDgrsaiVSTTGNPDCHVILRG-----GNKGP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 230 NYHYENLLETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWhtkIRNYVRGFLIESYLEDGRQD--KP 307
Cdd:PRK09261 241 NYDAESVAEAKERLEKAGL-PPRIMIDCSHANSGKDHKRQPEVARDVAAQIAA---GNKAIIGVMIESHLVEGNQDlpPK 316

                        330       340
                 ....*....|....*....|....*...
gi 446427869 308 DVFGKSITDPCLGWDKTEMLIRDIYNSL 335
Cdd:PRK09261 317 LVYGQSITDACIGWEDTEALLRELAEAV 344
AroG1 COG0722
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
 13-335 2.60e-88

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440486  Cd Length: 351  Bit Score: 268.86  E-value: 2.60e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  13 EILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMFLVMRVYTAKPR 92
Cdd:COG0722   20 AELKEELPLSEAAAETVAESRQAIRDILHGKDDRLLVVVGPCSIHDPDAALEYARRLKALAEELSDDLLIVMRVYFEKPR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  93 TNGdGYKGLVH--HSDklGVF------FQARKMHYDIIrETGLLTADELLypEMLSV--MDDLVSYYAIGARSVEDQGHR 162
Cdd:COG0722  100 TTV-GWKGLINdpHLD--GSFdinkglRLARKLLLDIN-ELGLPAATEFL--DPITPqyIADLISWGAIGARTTESQTHR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 163 FISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGYHNAdyrsiPNYHYENLL 237
Cdd:COG0722  174 ELASGLSCPVGFKNGTDGNLQIAIDAIRAASAPHHFLGIDKDgqsaiVQTTGNPDCHVILRGGKGG-----PNYDAESVA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 238 ETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWHTKirnYVRGFLIESYLEDGRQDKPD----VFGKS 313
Cdd:COG0722  249 AAEEALAKAGL-PPRLMVDCSHANSGKDHRRQPEVAEDVAAQIAAGNR---SIIGVMLESHLVEGNQDLPPgsplVYGQS 324

                        330       340
                 ....*....|....*....|..
gi 446427869 314 ITDPCLGWDKTEMLIRDIYNSL 335
Cdd:COG0722  325 ITDACIGWETTEELLRELAEAV 346
aroFGH TIGR00034
phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid ...
 2-335 5.51e-80

phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 129145  Cd Length: 344  Bit Score: 247.33  E-value: 5.51e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869    2 GFHQLsdkINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMF 81
Cdd:TIGR00034   7 RIDEL---LTPAELAAKFPLTPKQAANVAQSRQEIADIIAGKDDRLLVVIGPCSIHDPEAAIEYATRLKALREELKDDLE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   82 LVMRVYTAKPRTNgDGYKGLVHHSDKLGVF-----FQ-ARKMHYDIIrETGLLTADELLYPEMLSVMDDLVSYYAIGARS 155
Cdd:TIGR00034  84 IVMRVYFEKPRTT-VGWKGLINDPDLNGSFrinhgLRiARKLLLDLV-NLGLPIAGEFLDMISPQYLADLFSWGAIGART 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  156 VEDQGHRFISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGYHNadyrsiPN 230
Cdd:TIGR00034 162 TESQVHRELASGLSCPVGFKNGTDGNLQVAIDAIRAAAAPHYFLSVTKDgqmaiVQTSGNPDGHIILRGGKK------PN 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  231 YHYENLLETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLAdrqwhtKIR---NYVRGFLIESYLEDGRQD-- 305
Cdd:TIGR00034 236 YSAADVAAAKKQLEKAGL-PPHLMIDFSHGNSNKDHRRQPDVAEDVCE------QIAngsKAIIGVMIESNLVEGNQSip 308

                         330       340       350
                  ....*....|....*....|....*....|..
gi 446427869  306 --KPDVFGKSITDPCLGWDKTEMLIRDIYNSL 335
Cdd:TIGR00034 309 ggQPLKYGQSITDACIGWEDTEALLRQLADAV 340
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 38-329 1.07e-49

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 166.72  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   38 NIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAafKDKMFLVMRVYTAKPRTNGDGYKGLVhhsDKLGVffqarKM 117
Cdd:pfam00793   9 DIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGA--KLKLIIIMRAYFEKPRTSPVGFKGLG---NDPDL-----NI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  118 HYDIIRETGLLTADELLYPEMLSVMDDLVSYYAIGARSVEDQGHRFISSGIDAPVGMKNPTsgnlrvmFNAVYAAQNQQE 197
Cdd:pfam00793  79 LFRIKDGLGLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGT-------DAAIDEMLAAAE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  198 --LFYQNkqvrTDGNLLSHVILRGYHnadyrsIPNYHYENLLETITHYEETDLqnPFIVVDTNHDNSGKQFLEQIRIVKS 275
Cdd:pfam00793 152 yhLFLGV----TKGNILCERGIRGGE------GPNRNTLDVSAVAILKEETGH--LPVMVDVSHANGRKDGGRQPLVLPL 219

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446427869  276 VLAdrqwhtKIRNYVRGFLIESYLEDGRQDKPD----VFGKSITDPCLGWDKTEMLIR 329
Cdd:pfam00793 220 AKA------AIAVGIDGLMIEVHPNPGNALSDGpqqlKYGKSETDACILWELTELLLE 271
 
Name Accession Description Interval E-value
PRK09261 PRK09261
phospho-2-dehydro-3-deoxyheptonate aldolase; Validated
 1-335 4.00e-160

phospho-2-dehydro-3-deoxyheptonate aldolase; Validated


Pssm-ID: 236435  Cd Length: 349  Bit Score: 451.16  E-value: 4.00e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   1 MGFHQLSDKINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKM 80
Cdd:PRK09261   8 LRIKEIKPLIPPAELKEELPLTEEAAETVARSRKEIHNILHGKDDRLLVVVGPCSIHDPKAALEYARRLAKLREELKDKL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  81 FLVMRVYTAKPRTNgDGYKGLVHHSDKLGVF------FQARKMHYDIIrETGLLTADELLYPEMLSVMDDLVSYYAIGAR 154
Cdd:PRK09261  88 EIVMRVYFEKPRTT-VGWKGLINDPDLDGSFdindglRIARKLLLDIN-ELGLPAATEFLDPITPQYIADLISWGAIGAR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 155 SVEDQGHRFISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGyhnadYRSIP 229
Cdd:PRK09261 166 TTESQVHRELASGLSCPVGFKNGTDGNIKVAIDAIIAASAPHHFLGITKDgrsaiVSTTGNPDCHVILRG-----GNKGP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 230 NYHYENLLETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWhtkIRNYVRGFLIESYLEDGRQD--KP 307
Cdd:PRK09261 241 NYDAESVAEAKERLEKAGL-PPRIMIDCSHANSGKDHKRQPEVARDVAAQIAA---GNKAIIGVMIESHLVEGNQDlpPK 316

                        330       340
                 ....*....|....*....|....*...
gi 446427869 308 DVFGKSITDPCLGWDKTEMLIRDIYNSL 335
Cdd:PRK09261 317 LVYGQSITDACIGWEDTEALLRELAEAV 344
PRK12755 PRK12755
phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
 1-335 2.74e-134

phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional


Pssm-ID: 237190  Cd Length: 353  Bit Score: 385.74  E-value: 2.74e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   1 MGFHQLSDKINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKM 80
Cdd:PRK12755   9 VRITAEQPLITPEELKAELPLSEAAQAQVAASRQAIADILHGRDDRLLVVVGPCSIHDPEAALEYARRLKALADELSDRL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  81 FLVMRVYTAKPRTNgDGYKGLVHHSDKLGVF------FQARKMHYDIIrETGLLTADELLYPEMLSVMDDLVSYYAIGAR 154
Cdd:PRK12755  89 LIVMRVYFEKPRTT-VGWKGLINDPHLDGSFdieeglRIARKLLLDLV-ELGLPLATEALDPISPQYLGDLISWGAIGAR 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 155 SVEDQGHRFISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGYHNAdyrsiP 229
Cdd:PRK12755 167 TTESQTHREMASGLSMPVGFKNGTDGSLKVAINAIRAAAQPHRFLGINQEgqvalLETRGNPDGHVILRGGKKG-----P 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 230 NYHYENLLETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWHTKirnYVRGFLIESYLEDGRQDKPD- 308
Cdd:PRK12755 242 NYDAASVAACEAQLEKAGL-RPRLMIDCSHANSGKDYRRQPAVAEDVVAQIAAGNR---SIIGVMIESHLEEGNQSSPPl 317

                        330       340       350
                 ....*....|....*....|....*....|
gi 446427869 309 ---VFGKSITDPCLGWDKTEMLIRDIYNSL 335
Cdd:PRK12755 318 selKYGVSITDACIGWETTEALLRELAQAL 347
AroG1 COG0722
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
 13-335 2.60e-88

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440486  Cd Length: 351  Bit Score: 268.86  E-value: 2.60e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  13 EILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMFLVMRVYTAKPR 92
Cdd:COG0722   20 AELKEELPLSEAAAETVAESRQAIRDILHGKDDRLLVVVGPCSIHDPDAALEYARRLKALAEELSDDLLIVMRVYFEKPR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  93 TNGdGYKGLVH--HSDklGVF------FQARKMHYDIIrETGLLTADELLypEMLSV--MDDLVSYYAIGARSVEDQGHR 162
Cdd:COG0722  100 TTV-GWKGLINdpHLD--GSFdinkglRLARKLLLDIN-ELGLPAATEFL--DPITPqyIADLISWGAIGARTTESQTHR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 163 FISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGYHNAdyrsiPNYHYENLL 237
Cdd:COG0722  174 ELASGLSCPVGFKNGTDGNLQIAIDAIRAASAPHHFLGIDKDgqsaiVQTTGNPDCHVILRGGKGG-----PNYDAESVA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 238 ETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWHTKirnYVRGFLIESYLEDGRQDKPD----VFGKS 313
Cdd:COG0722  249 AAEEALAKAGL-PPRLMVDCSHANSGKDHRRQPEVAEDVAAQIAAGNR---SIIGVMLESHLVEGNQDLPPgsplVYGQS 324

                        330       340
                 ....*....|....*....|..
gi 446427869 314 ITDPCLGWDKTEMLIRDIYNSL 335
Cdd:COG0722  325 ITDACIGWETTEELLRELAEAV 346
aroFGH TIGR00034
phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid ...
 2-335 5.51e-80

phospho-2-dehydro-3-deoxyheptonate aldolase; [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 129145  Cd Length: 344  Bit Score: 247.33  E-value: 5.51e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869    2 GFHQLsdkINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMF 81
Cdd:TIGR00034   7 RIDEL---LTPAELAAKFPLTPKQAANVAQSRQEIADIIAGKDDRLLVVIGPCSIHDPEAAIEYATRLKALREELKDDLE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   82 LVMRVYTAKPRTNgDGYKGLVHHSDKLGVF-----FQ-ARKMHYDIIrETGLLTADELLYPEMLSVMDDLVSYYAIGARS 155
Cdd:TIGR00034  84 IVMRVYFEKPRTT-VGWKGLINDPDLNGSFrinhgLRiARKLLLDLV-NLGLPIAGEFLDMISPQYLADLFSWGAIGART 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  156 VEDQGHRFISSGIDAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGYHNadyrsiPN 230
Cdd:TIGR00034 162 TESQVHRELASGLSCPVGFKNGTDGNLQVAIDAIRAAAAPHYFLSVTKDgqmaiVQTSGNPDGHIILRGGKK------PN 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  231 YHYENLLETITHYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLAdrqwhtKIR---NYVRGFLIESYLEDGRQD-- 305
Cdd:TIGR00034 236 YSAADVAAAKKQLEKAGL-PPHLMIDFSHGNSNKDHRRQPDVAEDVCE------QIAngsKAIIGVMIESNLVEGNQSip 308

                         330       340       350
                  ....*....|....*....|....*....|..
gi 446427869  306 --KPDVFGKSITDPCLGWDKTEMLIRDIYNSL 335
Cdd:TIGR00034 309 ggQPLKYGQSITDACIGWEDTEALLRQLADAV 340
PRK12756 PRK12756
Trp-sensitive 3-deoxy-7-phosphoheptulonate synthase AroH;
15-330 1.16e-76

Trp-sensitive 3-deoxy-7-phosphoheptulonate synthase AroH;


Pssm-ID: 183726  Cd Length: 348  Bit Score: 238.68  E-value: 1.16e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  15 LKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMFLVMRVYTAKPRTN 94
Cdd:PRK12756  21 LASEYPITPDVADHVTDSRRRIEKILNGEDPRLLVIIGPCSIHDTDAALDYATRLAALREQYQDRLEIVMRTYFEKPRTV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  95 GdGYKGLVHHSDKLGVFF------QARKMHYDiIRETGLLTADELLYPEMLSVMDDLVSYYAIGARSVEDQGHRFISSGI 168
Cdd:PRK12756 101 V-GWKGLISDPDLDGSYRvnhgleLARKLLLQ-INELGLPTATEFLDMVTGQYIADLISWGAIGARTTESQIHREMASAL 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 169 DAPVGMKNPTSGNLRVMFNAVYAAQNQQELFYQNKQ-----VRTDGNLLSHVILRGYHNadyrsiPNYHYENLLETITHY 243
Cdd:PRK12756 179 SCPVGFKNGTDGNTRIAIDAIRAARASHMFLSPDKDgqmtiYQTSGNPYGHIIMRGGKK------PNYHAEDIAAACDTL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 244 EETDLQnPFIVVDTNHDNSGKQFLEQIRIVKSVLAdrqwhtKIRN---YVRGFLIESYLEDGRQD----KPDVFGKSITD 316
Cdd:PRK12756 253 REFDLP-EHLVVDFSHGNCQKQHRRQLDVAEDICQ------QIRNgstAIAGIMAESFLREGTQKivagQPLTYGQSITD 325

                        330
                 ....*....|....
gi 446427869 317 PCLGWDKTEMLIRD 330
Cdd:PRK12756 326 PCLGWEDTERLLEL 339
PRK12822 PRK12822
phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
 13-328 7.46e-71

phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional


Pssm-ID: 237217  Cd Length: 356  Bit Score: 224.32  E-value: 7.46e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  13 EILKQkTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMFLVMRVYTAKPR 92
Cdd:PRK12822  21 EILKE-IPCSEETETWISQQRQDIRNILLGKDPRLLVIIGPCSIHDPQAALEYAKRLAVLQHQYLDQLYIVMRTYFEKPR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  93 TNGdGYKGLVH-----HSDKLGVFFQ-ARKMHYDIIReTGLLTADELLYPEMLSVMDDLVSYYAIGARSVEDQGHRFISS 166
Cdd:PRK12822 100 TRK-GWKGLIFdpdldGSNDIEKGLRlARQLLLSINT-LGLATATEFLDTTSFPYIADLICWGAIGARTTESQVHRQLAS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 167 GIDAPVGMKNPTSGNLRVMFNAVYAAQNQQeLFYQNKQ------VRTDGNLLSHVILRGYHNadyrsiPNYHYENLLETI 240
Cdd:PRK12822 178 ALPCPVGFKNGTDGNIRIAIDAILAARSPH-LVTVPGLtgcistLLSDGNPHGHIILRGGRE------PNYGLSDVTKAS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869 241 THYEETDLqNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRqwhTKIRNYVRGFLIESYLEDGRQDKPD---VFGKSITDP 317
Cdd:PRK12822 251 KLLHDEGL-NHRLIIDCSHGNSQKVAKNQISVARELCDQL---KEGEGAIAGVMVESFLQGGSQKADSaplEYGQSVTDE 326

                        330
                 ....*....|.
gi 446427869 318 CLGWDKTEMLI 328
Cdd:PRK12822 327 CLSWQDTEQLL 337
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 38-329 1.07e-49

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 166.72  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869   38 NIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAafKDKMFLVMRVYTAKPRTNGDGYKGLVhhsDKLGVffqarKM 117
Cdd:pfam00793   9 DIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGA--KLKLIIIMRAYFEKPRTSPVGFKGLG---NDPDL-----NI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  118 HYDIIRETGLLTADELLYPEMLSVMDDLVSYYAIGARSVEDQGHRFISSGIDAPVGMKNPTsgnlrvmFNAVYAAQNQQE 197
Cdd:pfam00793  79 LFRIKDGLGLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGT-------DAAIDEMLAAAE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  198 --LFYQNkqvrTDGNLLSHVILRGYHnadyrsIPNYHYENLLETITHYEETDLqnPFIVVDTNHDNSGKQFLEQIRIVKS 275
Cdd:pfam00793 152 yhLFLGV----TKGNILCERGIRGGE------GPNRNTLDVSAVAILKEETGH--LPVMVDVSHANGRKDGGRQPLVLPL 219

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446427869  276 VLAdrqwhtKIRNYVRGFLIESYLEDGRQDKPD----VFGKSITDPCLGWDKTEMLIR 329
Cdd:pfam00793 220 AKA------AIAVGIDGLMIEVHPNPGNALSDGpqqlKYGKSETDACILWELTELLLE 271
PRK12595 PRK12595
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed
 13-154 3.62e-06

bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed


Pssm-ID: 183614 [Multi-domain]  Cd Length: 360  Bit Score: 48.05  E-value: 3.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  13 EILKQ--KTSLDLE---------VSQKKlaKEEELKNIIKGE---DQRFLVIVGPCSADNPKAVLTYAKRLakleaafKD 78
Cdd:PRK12595  73 HLFKEifKASLELQeddnrkallVSRKK--KPEDTIVDVKGEvigDGNQSFIFGPCSVESYEQVEAVAKAL-------KA 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446427869  79 KMFLVMRVYTAKPRTNGDGYKGlvhhsdkLGVffQARKMHYDIIRETGLLTADELLYPEMLSVMDDLVSYYAIGAR 154
Cdd:PRK12595 144 KGLKLLRGGAFKPRTSPYDFQG-------LGV--EGLKILKQVADEYGLAVISEIVNPADVEVALDYVDVIQIGAR 210
PRK08673 PRK08673
3-deoxy-7-phosphoheptulonate synthase; Reviewed
 35-154 3.00e-04

3-deoxy-7-phosphoheptulonate synthase; Reviewed


Pssm-ID: 181535 [Multi-domain]  Cd Length: 335  Bit Score: 42.19  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  35 ELKNIIKGEDqRFLVIVGPCSADNPKAVLTYAKRLAKLEA------AFKdkmflvmrvytakPRTN-----GDGYKGLVH 103
Cdd:PRK08673  83 KVGDVEIGGG-KPVVIAGPCSVESEEQILEIARAVKEAGAqilrggAFK-------------PRTSpysfqGLGEEGLKL 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446427869 104 HSdklgvffQARKmhydiirETGLLTADELLYPEMLsvmdDLVSYYA----IGAR 154
Cdd:PRK08673 149 LA-------EARE-------ETGLPIVTEVMDPRDV----ELVAEYVdilqIGAR 185
PRK13396 PRK13396
3-deoxy-7-phosphoheptulonate synthase; Provisional
 42-158 3.06e-03

3-deoxy-7-phosphoheptulonate synthase; Provisional


Pssm-ID: 237376 [Multi-domain]  Cd Length: 352  Bit Score: 38.97  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446427869  42 GEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFkdkmflvMRVYTAKPRTNGDGYKGlvHHSDKLGVFFQARKmhydi 121
Cdd:PRK13396  97 GENHPVVVVAGPCSVENEEMIVETAKRVKAAGAKF-------LRGGAYKPRTSPYAFQG--HGESALELLAAARE----- 162

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446427869 122 irETGLLTADELLYPEMLSVMDDLVSYYAIGARSVED 158
Cdd:PRK13396 163 --ATGLGIITEVMDAADLEKIAEVADVIQVGARNMQN 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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