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Conserved domains on  [gi|447036381|ref|WP_001113637|]
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MULTISPECIES: nitrate/nitrite response regulator protein NarP [Enterobacteriaceae]

Protein Classification

response regulator transcription factor NarP( domain architecture ID 11484697)

two-component system response regulator transcription factor NarP binds DNA upon phosphorylation and functions as transcriptional regulator that activates expression of the nitrate reductase (narGHJI) operon

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
1-215 9.25e-144

nitrate/nitrite response regulator protein NarP;


:

Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 399.61  E-value: 9.25e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   1 MPEATPFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:PRK10403   1 MPEATPFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELD 160
Cdd:PRK10403  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447036381 161 VLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ 215
Cdd:PRK10403 161 VLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ 215
 
Name Accession Description Interval E-value
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
1-215 9.25e-144

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 399.61  E-value: 9.25e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   1 MPEATPFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:PRK10403   1 MPEATPFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELD 160
Cdd:PRK10403  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447036381 161 VLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ 215
Cdd:PRK10403 161 VLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ 215
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 9-125 4.76e-57

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 176.38  E-value: 4.76e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAK 125
Cdd:cd19931   81 SDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAAS 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 9-212 1.08e-40

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 135.02  E-value: 1.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALrrdgvtaqiiiltv 88
Cdd:COG2197    4 VLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL-------------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 sdassdvfalidagadgyllkdsdpevlleairagakgskvfservnqylreremfgaeedpfsvLTERELDVLHELAQG 168
Cdd:COG2197   70 -----------------------------------------------------------------LTPREREVLRLLAEG 84

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 447036381 169 LSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQR 212
Cdd:COG2197   85 LSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLG 128
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 9-121 1.39e-33

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 116.10  E-value: 1.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381    9 VMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLE-KEGY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 447036381   89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 154-208 1.02e-21

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 84.12  E-value: 1.02e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 447036381   154 LTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILF 208
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 167-196 2.38e-06

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 46.02  E-value: 2.38e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 447036381  167 QGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:TIGR02985 128 EGLSNKEIAEELGISVKTVEYHITKALKFL 157
 
Name Accession Description Interval E-value
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
1-215 9.25e-144

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 399.61  E-value: 9.25e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   1 MPEATPFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:PRK10403   1 MPEATPFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELD 160
Cdd:PRK10403  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447036381 161 VLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ 215
Cdd:PRK10403 161 VLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ 215
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-214 1.83e-84

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 249.56  E-value: 1.83e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   1 MPEATPFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:PRK10651   1 MSNQEPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLRE--REMFGAEEDPFSVLTERE 158
Cdd:PRK10651  81 GRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAAslRANRATTERDVNQLTPRE 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447036381 159 LDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGA 214
Cdd:PRK10651 161 RDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERIF 216
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 9-125 4.76e-57

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 176.38  E-value: 4.76e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAK 125
Cdd:cd19931   81 SDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAAS 117
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 9-122 1.47e-46

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 149.58  E-value: 1.47e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRA 114
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 9-212 1.08e-40

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 135.02  E-value: 1.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALrrdgvtaqiiiltv 88
Cdd:COG2197    4 VLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL-------------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 sdassdvfalidagadgyllkdsdpevlleairagakgskvfservnqylreremfgaeedpfsvLTERELDVLHELAQG 168
Cdd:COG2197   70 -----------------------------------------------------------------LTPREREVLRLLAEG 84

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 447036381 169 LSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQR 212
Cdd:COG2197   85 LSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLG 128
PRK15369 PRK15369
two component system response regulator;
6-198 1.07e-37

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 130.20  E-value: 1.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   6 PFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIII 85
Cdd:PRK15369   3 NYKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPfSVLTERELDVLHEL 165
Cdd:PRK15369  83 LTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALLNADDTNP-PLLTPRERQILKLI 161

                        170       180       190
                 ....*....|....*....|....*....|...
gi 447036381 166 AQGLSNKQIASVLNISEQTVKVHIRNLLRKLNV 198
Cdd:PRK15369 162 TEGYTNRDIAEQLSISIKTVETHRLNMMRKLDV 194
PRK09483 PRK09483
response regulator; Provisional
 9-207 1.95e-35

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 124.45  E-value: 1.95e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:PRK09483   4 VLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLTV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQG 168
Cdd:PRK09483  84 HTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAQQMALSQIEPATENPFASLSERELQIMLMITKG 163

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 447036381 169 LSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATIL 207
Cdd:PRK09483 164 QKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHL 202
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 8-196 1.98e-34

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 121.60  E-value: 1.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:COG0745    3 RILVVEDDPDIRELLADALERE-GYEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELA- 166
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLRVGDLLDLAAREVTRDGEPVELTPKEFRLLELLMr 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 447036381 167 ---QGLSNKQIASVL----NISEQTVKVHIRNLLRKL 196
Cdd:COG0745  161 npgRVVSREQLLEEVwgydYGDDRTVDVHISRLRKKL 197
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 9-121 1.39e-33

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 116.10  E-value: 1.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381    9 VMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLE-KEGY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 447036381   89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 9-200 1.62e-33

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 118.66  E-value: 1.62e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESA-GLRVET-FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLT- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 sdASSDVFALIDA---GADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAeedpfsvLTERELDVLHEL 165
Cdd:COG4566   79 --GHGDVPMAVRAmkaGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLAS-------LTPREREVLDLV 149

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 447036381 166 AQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRS 200
Cdd:COG4566  150 VAGLSNKQIARELGISPRTVEVHRANVMEKLGARS 184
PRK10360 PRK10360
transcriptional regulator UhpA;
9-202 2.67e-30

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 110.45  E-value: 2.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTaqiIILTV 88
Cdd:PRK10360   4 VALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMAT---IMLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLReremfGAEEDPfsvLTERELDVLHELAQG 168
Cdd:PRK10360  81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLA-----SGRQDP---LTKRERQVAEKLAQG 152

                        170       180       190
                 ....*....|....*....|....*....|....
gi 447036381 169 LSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRV 202
Cdd:PRK10360 153 MAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDV 186
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 9-109 4.32e-29

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 104.47  E-value: 4.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILSG 81

                         90       100
                 ....*....|....*....|.
gi 447036381  89 SDASSDVFALIDAGADGYLLK 109
Cdd:COG4753   82 YSDFEYAQEAIKLGADDYLLK 102
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 5-122 2.54e-27

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 101.20  E-value: 2.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   5 TPFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQII 84
Cdd:COG4565    2 KMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVI 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447036381  85 ILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:COG4565   82 VITAARDPETVREALRAGVVDYLIKPFTFERLREALER 119
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 9-121 8.07e-26

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 96.64  E-value: 8.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLE-LDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDwEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447036381  88 vsdASSDvFAL----IDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17536   81 ---GYDD-FEYaqkaIRLGVVDYLLKPVDEEELEEALE 114
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 9-155 1.09e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.51  E-value: 1.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:COG3279    4 ILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT- 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447036381  89 sdASSDvFAL--IDAGADGYLLKDSDPEVLLEAIragakgskvfsERVNQYLREREMFGAEEDPFSVLT 155
Cdd:COG3279   83 --AYDE-YALeaFEVNAVDYLLKPIDEERLAKAL-----------EKAKERLEAKAAAEASPEEKDRIF 137
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 2-121 1.52e-25

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 96.07  E-value: 1.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   2 PEATPFQVMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTA 81
Cdd:COG0784    1 PPLGGKRILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 447036381  82 Q--IIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:COG0784   79 DipIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALR 120
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-122 6.42e-25

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 97.16  E-value: 6.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   1 MPEATPFQVMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:COG3437    1 MRTGQAPTVLIVDDDPENLELLRQLLR-TLGYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPST 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 447036381  81 AQI--IILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:COG3437   79 RDIpvIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRN 122
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 6-120 8.10e-25

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 95.75  E-value: 8.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   6 PFQVMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ--I 83
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLE-AAGYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADipI 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447036381  84 IILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:COG3706   79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
10-200 9.20e-25

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 96.50  E-value: 9.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLELDpGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTvs 89
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIKN-DIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  90 dASSDVF---ALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREremFGAEEDPFSVLTERELDVLHELA 166
Cdd:PRK09958  81 -AKNDHFygkHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGS---LTSDQQKLDSLSKQEISVMRYIL 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 447036381 167 QGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRS 200
Cdd:PRK09958 157 DGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKS 190
GerE pfam00196
Bacterial regulatory proteins, luxR family;
152-208 1.15e-23

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 89.18  E-value: 1.15e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 447036381  152 SVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILF 208
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
6-202 1.40e-23

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 93.40  E-value: 1.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   6 PFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRdgVTAQIII 85
Cdd:PRK09935   3 PASVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQ--IQSTVKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  86 LTVSDASSDVFA--LIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVF-SERVNQYLREREMFGAEEDpfSVLTERELDVL 162
Cdd:PRK09935  81 LFLSSKSECFYAgrAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFpSETLNYIKSNKCSTNSSTD--TVLSNREVTIL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 447036381 163 HELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRV 202
Cdd:PRK09935 159 RYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIV 198
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 9-121 1.55e-23

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 96.96  E-value: 1.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:COG2204    5 ILVVDDDPDIRRLLKELLERA-GYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:COG2204   83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVE 115
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 9-121 5.46e-23

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 89.25  E-value: 5.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIR 113
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 10-109 5.68e-23

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 88.44  E-value: 5.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVS 89
Cdd:cd00156    1 LIVDDDPAIRELLKSLLERE-GYEVD-TAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78

                         90       100
                 ....*....|....*....|
gi 447036381  90 DASSDVFALIDAGADGYLLK 109
Cdd:cd00156   79 ADEEDAVRALELGADDYLVK 98
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 149-212 8.30e-23

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 87.32  E-value: 8.30e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447036381 149 DPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQR 212
Cdd:COG5905    8 SHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLG 71
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 9-121 9.46e-23

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 88.99  E-value: 9.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17541    3 VLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMVSSL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 447036381  89 SDASSD-VFALIDAGADGYLLKDSDP---------EVLLEAIR 121
Cdd:cd17541   83 TEEGAEiTLEALELGAVDFIAKPSGGisldleeiaEELIEKIK 125
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 154-208 1.02e-21

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 84.12  E-value: 1.02e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 447036381   154 LTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILF 208
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 7-121 1.22e-21

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 85.79  E-value: 1.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   7 FQVMIVDDHPLMRRGVRQLLELDpGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKA-GYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  87 TVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17542   80 SAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVE 114
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 10-109 1.28e-21

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 85.15  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVS 89
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKE-GYEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78

                         90       100
                 ....*....|....*....|
gi 447036381  90 DASSDVFALIDAGADGYLLK 109
Cdd:cd17574   79 DEEEDKVLGLELGADDYITK 98
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 154-210 9.59e-21

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 81.43  E-value: 9.59e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 447036381 154 LTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQ 210
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 9-120 5.98e-20

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 81.36  E-value: 5.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ---III 85
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKL-GYEVDV-AENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGRrtpIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:cd17546   79 LTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 9-120 1.01e-19

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 80.85  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd19923    3 VLVVDDFSTMRRIIKNLLK-ELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALSHLPVLMV 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SD--ASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:cd19923   82 TAeaKKENVIAAAQAGVNNYIVKPFTAATLKEKL 115
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 8-122 3.16e-19

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 79.77  E-value: 3.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHP----LMRRGVRqllELDPGFEVVAeAGDGASAIDL-------ANRLDIDVILLDLNMKGMSGLDTLNALRR 76
Cdd:cd17557    1 TILLVEDNPgdaeLIQEAFK---EAGVPNELHV-VRDGEEALDFlrgegeyADAPRPDLILLDLNMPRMDGFEVLREIKA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 447036381  77 DGVTAQI--IILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17557   77 DPDLRRIpvVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRS 124
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 9-203 5.78e-19

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 81.42  E-value: 5.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKG---MSGLDTLNALRRDGVTAQIII 85
Cdd:PRK10840   6 VIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGdkyGDGITLIKYIKRHFPSLSIIV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPfsvLTERELDVLHEL 165
Cdd:PRK10840  86 LTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKR---LSPKESEVLRLF 162

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 447036381 166 AQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVA 203
Cdd:PRK10840 163 AEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIA 200
fixJ PRK09390
response regulator FixJ; Provisional
 9-200 9.44e-19

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 80.43  E-value: 9.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:PRK09390   6 VHVVDDDEAMRDSLAFLLDSA-GFEVRLFE-SAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMT- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 sdASSDVFALIDA---GADGYLLKDSDPEVLLEAIRAGAKGSK--VFSERVNQYLRERemfgaeedpFSVLTERELDVLH 163
Cdd:PRK09390  83 --GHGDVPLAVEAmklGAVDFIEKPFEDERLIGAIERALAQAPeaAKSEAVAADIRAR---------IASLSERERQVMD 151

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 447036381 164 ELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRS 200
Cdd:PRK09390 152 GLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGS 188
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 9-121 1.97e-18

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 77.19  E-value: 1.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  89 SDAssdvFAL--IDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17532   81 YDE----YAVeaFELNAVDYLLKPFSEERLAEALA 111
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 9-121 4.51e-18

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 76.57  E-value: 4.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17562    3 ILAVDDSASIRQMVSFTLR-GAGYEVV-EAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLPAYKFTPILML 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  89 SDASSDVF--ALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17562   81 TTESSDEKkqEGKAAGATGWLVKPFDPEQLLEVVK 115
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 9-121 6.41e-18

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 78.07  E-value: 6.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIIILTV 88
Cdd:COG3707    6 VLVVDDEPLRRADLREGLR-EAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEER-PAPVILLTA 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALE 116
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
6-124 7.62e-18

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 80.58  E-value: 7.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   6 PFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLN---ALRRdgvtaq 82
Cdd:PRK00742   3 KIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEkimRLRP------ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 447036381  83 IIILTVSdassdvfALIDAGAdgyllkdsdpEVLLEAIRAGA 124
Cdd:PRK00742  77 TPVVMVS-------SLTERGA----------EITLRALELGA 101
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 9-122 8.40e-18

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 75.60  E-value: 8.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKA-GYAV-DWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTA 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17624   79 RDGVDDRVAGLDAGADDYLVKPFALEELLARLRA 112
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 9-109 8.82e-17

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 72.53  E-value: 8.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--IIL 86
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAE-GYEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIpvIMI 79

                         90       100
                 ....*....|....*....|...
gi 447036381  87 TVSDASSDVFALIDAGADGYLLK 109
Cdd:cd17538   80 TALDDREDRIRGLEAGADDFLSK 102
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 9-122 1.09e-16

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 72.70  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLS-DAGY-VVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTA 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd19934   79 RDSWQDKVEGLDAGADDYLTKPFHIEELLARLRA 112
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 9-121 1.23e-16

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 72.64  E-value: 1.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17554    3 ILVVDDEENIRELYKEELE-DEGYEVVT-AGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  89 SDASSDVFALIdaGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17554   81 YSEYKSDFSSW--AADAYVVKSSDLTELKETIK 111
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 9-122 1.52e-16

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 72.42  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFE-GYEV-ETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTA 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17627   79 RDSVSDRVAGLDAGADDYLVKPFALEELLARVRA 112
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 9-121 1.42e-15

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 69.88  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIII--L 86
Cdd:cd17548    2 ILIVEDNPLNMKLARDLLESA-GYEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPATRDIPViaL 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  87 TVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17548   80 TAYAMKGDREKILEAGCDGYISKPIDTREFLETVA 114
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 9-109 1.84e-15

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 69.01  E-value: 1.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEE-GY-AVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTA 78

                         90       100
                 ....*....|....*....|..
gi 447036381  89 SDASSD-VFALiDAGADGYLLK 109
Cdd:cd19935   79 RDSVEDrVKGL-DLGADDYLVK 99
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 9-122 4.39e-15

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 69.95  E-value: 4.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT- 87
Cdd:COG4567    7 LLLVDDDEAFARVLARALERR-GFEVTT-AASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTg 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447036381  88 -VSDASsdVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:COG4567   85 yASIAT--AVEAIKLGADDYLAKPADADDLLAALER 118
PRK10610 PRK10610
chemotaxis protein CheY;
10-109 7.49e-15

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 68.46  E-value: 7.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVS 89
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLLK-ELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPVLMVT 87

                         90       100
                 ....*....|....*....|..
gi 447036381  90 DAS--SDVFALIDAGADGYLLK 109
Cdd:PRK10610  88 AEAkkENIIAAAQAGASGYVVK 109
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
27-212 8.27e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 69.78  E-value: 8.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  27 ELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGY 106
Cdd:COG2771    1 LLLLALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381 107 LLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVK 186
Cdd:COG2771   81 LLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVR 160

                        170       180
                 ....*....|....*....|....*.
gi 447036381 187 VHIRNLLRKLNVRSRVAATILFLQQR 212
Cdd:COG2771  161 THLKRIYRKLGVSSRAELVALALRLG 186
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 8-121 1.25e-14

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 67.58  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--II 85
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLAGWEVL-TASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQANPETQSIpvIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17552   82 LTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIA 117
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 9-122 1.44e-14

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 67.38  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYE-GWDVET-AADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTA 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17615   80 KDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRA 113
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 8-125 1.50e-14

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 67.08  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ--III 85
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVS-FTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDvpIVM 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 447036381  86 LTVsdassdvfalidagadgyllkDSDPEVLLEAIRAGAK 125
Cdd:cd17551   81 ITA---------------------DTDREVRLRALEAGAT 99
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 9-109 1.61e-14

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 66.42  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRrDGVTAQIIILTV 88
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALE-AHGYRVF-EAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLR-EWSAVPVIVLSA 77

                         90       100
                 ....*....|....*....|.
gi 447036381  89 SDASSDVFALIDAGADGYLLK 109
Cdd:cd17620   78 RDEESDKIAALDAGADDYLTK 98
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 9-120 2.44e-14

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 66.50  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:cd19925    3 VLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT- 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  89 sdASSDVFALIDA---GADGYLLKDSDPEVLLEAI 120
Cdd:cd19925   82 --AANDVETVREAlrlGVVDYLIKPFTFERLRQRL 114
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 8-120 3.40e-14

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 66.28  E-value: 3.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVtAQIIILT 87
Cdd:cd19932    2 RVLIAEDEALIRMDLREMLE-EAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLT 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:cd19932   80 AYSQQDLVERAKEAGAMAYLVKPFSESDLIPAI 112
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 9-123 7.34e-14

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 65.30  E-value: 7.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17555    3 ILVIDDDEVVRESIAAYLE-DSGFQVL-QAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447036381  89 SDASSDVFALIDAGADGYLLKD-SDPEVLLEAIRAG 123
Cdd:cd17555   81 AGVMSDAVEALRLGAWDYLTKPiEDLAVLEHAVRRA 116
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 8-122 8.18e-14

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 65.35  E-value: 8.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--II 85
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLERA-GFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTRDIpiIM 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17618   80 LTARGEEEDKVRGLEAGADDYITKPFSPRELVARIKA 116
PRK10100 PRK10100
transcriptional regulator CsgD;
105-204 1.18e-13

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 67.20  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381 105 GYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLRERE-MFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQ 183
Cdd:PRK10100 106 GVFYAMEDQERVVNGLQGVLRGECYFTQKLASYLITHSgNYRYNSTESALLTHREKEILNKLRIGASNNEIARSLFISEN 185

                         90       100
                 ....*....|....*....|.
gi 447036381 184 TVKVHIRNLLRKLNVRSRVAA 204
Cdd:PRK10100 186 TVKTHLYNLFKKIAVKNRTQA 206
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
9-103 1.32e-13

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 68.37  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAqIIILTV 88
Cdd:PRK12555   3 IGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERPCP-ILIVTS 81

                         90
                 ....*....|....*..
gi 447036381  89 S--DASSDVFALIDAGA 103
Cdd:PRK12555  82 LteRNASRVFEAMGAGA 98
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 10-122 2.14e-13

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 64.16  E-value: 2.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLElDPGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVS 89
Cdd:cd17625    1 LVVEDEKDLSEAITKHLK-KEGYTV-DVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTAL 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  90 DASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17625   79 DAVEDRVKGLDLGADDYLPKPFSLAELLARIRA 111
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 9-109 2.87e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 63.30  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--IIL 86
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLR-AAGYRVLV-ATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATRHIpvIFL 78

                         90       100
                 ....*....|....*....|...
gi 447036381  87 TVSDASSDVFALIDAGADGYLLK 109
Cdd:cd19920   79 TALTDTEDKVKGFELGAVDYITK 101
PRK11697 PRK11697
two-component system response regulator BtsR;
9-139 1.53e-12

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 64.48  E-value: 1.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDgVTAQIIILTV 88
Cdd:PRK11697   4 VLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPE-HMPYIVFVTA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447036381  89 SDAssdvFAL--IDAGADGYLLKDSDPEVL---LEAIRAGAKGSKVFSERVNQYLR 139
Cdd:PRK11697  83 FDE----YAIkaFEEHAFDYLLKPIDPARLaktLARLRQERSPQDVLLPEAQPPLK 134
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
8-199 1.95e-12

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 64.05  E-value: 1.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRlDIDVILLDLNMKGMSGLDTLNALRRDGVTAqIIILT 87
Cdd:PRK10955   3 KILLVDDDRELTSLLKELLEME-GFNVIV-AHDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTHQTP-VIMLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMF--------GAEEDPFS----VLT 155
Cdd:PRK10955  79 ARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEvdalslnpGRQEASFDgqtlELT 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 447036381 156 ERELDVLHELAQG---------LSNKQIASVLNISEQTVKVHIRNLLRKLNVR 199
Cdd:PRK10955 159 GTEFTLLYLLAQHlgqvvsrehLSQEVLGKRLTPFDRAIDMHISNLRRKLPDR 211
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 9-122 2.01e-12

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 61.55  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIIILTV 88
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEME-GFNVRA-AHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTS-QVPVLMLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17623   78 RGDDIDRILGLELGADDYLPKPFNPRELVARIRA 111
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 9-120 8.83e-12

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 59.78  E-value: 8.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--IIL 86
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELE-GAEVTT-AHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTpaIAL 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  87 TVSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:cd17580   79 TGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 9-138 9.18e-12

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 60.07  E-value: 9.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpgFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALR-RDGVTAQIIILT 87
Cdd:cd17596    3 ILVVDDEVRSLEALRRTLEED--FDVLT-AASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVReRWPEVVRIIISG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVfsERVNQYL 138
Cdd:cd17596   80 YTDSEDIIAGINEAGIYQYLTKPWHPDQLLLTVRNAARLFEL--QRENERL 128
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 9-109 1.14e-11

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 58.93  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDG--VTAQIIIL 86
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLE-DQGFTVIA-ASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNAdfDTIPVIFL 78

                         90       100
                 ....*....|....*....|...
gi 447036381  87 TVSDASSDVFALIDAGADGYLLK 109
Cdd:cd19927   79 TAKGMTSDRIKGYNAGCDGYLSK 101
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 9-62 2.67e-11

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 56.81  E-value: 2.67e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 447036381     9 VMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNM 62
Cdd:smart00448   3 ILVVDDDPLLRELLKALLE-KEGYEVD-EATDGEEALELLKEEKPDLILLDIMM 54
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 9-122 2.88e-11

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 58.17  E-value: 2.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIIILTV 88
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQE-GYDVS-EAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQS-EVGIILVTG 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLeaIRA 122
Cdd:cd17619   80 RDDEVDRIVGLEIGADDYVTKPFNPRELL--VRA 111
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 10-122 3.47e-11

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 58.05  E-value: 3.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ--IIILT 87
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKE-GYEVVT-AYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSipIIMLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd19937   79 AKGEEFDKVLGLELGADDYITKPFSPRELLARVKA 113
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 9-122 3.79e-11

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 58.19  E-value: 3.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSE-GF-NVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSG 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17616   79 LADIEDKVKGLGFGADDYMTKPFHKDELVARIHA 112
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
165-213 3.83e-11

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 59.72  E-value: 3.83e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 447036381 165 LAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAAtILFLQQRG 213
Cdd:COG2909  134 LAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEA-VARARELG 181
PRK10643 PRK10643
two-component system response regulator PmrA;
8-122 8.24e-11

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 59.28  E-value: 8.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFevvaeAGDGASAIDLANRL----DIDVILLDLNMKGMSGLDTLNALRRDGVTAQI 83
Cdd:PRK10643   2 KILIVEDDTLLLQGLILALQTE-GY-----ACDCASTAREAEALlesgHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPV 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 447036381  84 IILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:PRK10643  76 LILTARDTLEDRVAGLDVGADDYLVKPFALEELHARIRA 114
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 7-120 1.12e-10

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 56.78  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   7 FQVMIVDDHPLMRRGVRQLLELDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86
Cdd:cd17593    1 MKVLICDDSSMARKQLARALPADWDVEIT-FAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVV 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 447036381  87 tvsdaSSDVFAL-----IDAGADGYLLKDSDPEVLLEAI 120
Cdd:cd17593   80 -----SGDVQPEakervLELGALAFLKKPFDPEKLAQLL 113
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 7-125 2.01e-10

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 56.26  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   7 FQVMIVDDHPLMRRGVRQLLElDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLR-REGYEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 447036381  87 TvsdASSDVFALIDAGADG----YLLKDSDPEVLLEAIRAGAK 125
Cdd:cd17569   79 T---GYADLDAAIEAINEGeiyrFLTKPWDDEELKETIRQALE 118
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 10-109 2.05e-10

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 55.74  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  10 MIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVS 89
Cdd:cd17565    2 YIVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQV 81

                         90       100
                 ....*....|....*....|
gi 447036381  90 DASSDVFALIDAGADGYLLK 109
Cdd:cd17565   82 SDKEMIGKAYQAGIEFFINK 101
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 9-121 2.44e-10

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 56.34  E-value: 2.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:cd17549    1 VLLVDDDADVREALQQTLELA-GFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILIT- 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447036381  89 sdASSDVFALIDA---GADGYLLKDSDPEVLLEAIR 121
Cdd:cd17549   78 --GHGDVPMAVEAmraGAYDFLEKPFDPERLLDVVR 111
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 8-122 2.73e-10

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 55.94  E-value: 2.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAqIIILT 87
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGE-GFDP-AFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVP-IVMLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17626   79 AKSDTVDVVLGLESGADDYVAKPFKPKELVARIRA 113
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
8-196 3.13e-10

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 57.81  E-value: 3.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--II 85
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQN-GFQPV-EAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIpvVM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKgsKVFSERVNQYLrerEMFGAEEDPFS--VLT-ERELD-- 160
Cdd:PRK10161  82 LTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMR--RISPMAVEEVI---EMQGLSLDPTShrVMAgEEPLEmg 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 447036381 161 -----VLHELA---------QGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:PRK10161 157 ptefkLLHFFMthpervysrEQLLNHVWGTNVYVEDRTVDVHIRRLRKAL 206
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
152-204 3.14e-10

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 59.19  E-value: 3.14e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 447036381 152 SVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAA 204
Cdd:PRK04841 837 SPLTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEA 889
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 9-114 4.19e-10

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 55.22  E-value: 4.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAID-LANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:cd17544    3 VLVVDDSATSRNHLRALLRRH-NFQVL-EAANGQEALEvLEQHPDIKLVITDYNMPEMDGFELVREIRKKYSRDQLAIIG 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 447036381  88 VSdaSSDVFAL----IDAGADGYLLKDSDPE 114
Cdd:cd17544   81 IS--ASGDNALsarfIKAGANDFLTKPFLPE 109
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 9-120 4.99e-10

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 55.11  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKG-MSGLDTLNALRRDGVTAqIIILT 87
Cdd:cd17534    3 ILIVEDEAIIALDLKEILE-SLGYEVVGIADSGEEAIELAEENKPDLILMDINLKGdMDGIEAAREIREKFDIP-VIFLT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  88 vSDASSDVFALI-DAGADGYLLKDSDPEVLLEAI 120
Cdd:cd17534   81 -AYSDEETLERAkETNPYGYLVKPFNERELKAAI 113
PRK15479 PRK15479
transcriptional regulator TctD;
8-167 1.01e-09

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 56.27  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:PRK15479   2 RLLLAEDNRELAHWLEKALV-QNGF-AVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQY----LREREMFGAEEDPFSvLTERELDVLH 163
Cdd:PRK15479  80 ARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLgeliFHDEGYFLLQGQPLA-LTPREQALLT 158


                 ....
gi 447036381 164 ELAQ 167
Cdd:PRK15479 159 VLMY 162
ompR PRK09468
osmolarity response regulator; Provisional
 9-167 1.16e-09

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 56.14  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLT-EQGFQVRS-AANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA----------GAKGSKV----FSE-RVNqyLREREMFGAEEDpfSV 153
Cdd:PRK09468  86 KGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAvlrrqapelpGAPSQEEeviaFGKfKLN--LGTRELFRGDEP--MP 161

                        170
                 ....*....|....
gi 447036381 154 LTERELDVLHELAQ 167
Cdd:PRK09468 162 LTTGEFAVLKALVS 175
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 9-122 1.65e-09

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 53.54  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDgVTAQIIILTV 88
Cdd:cd17622    3 ILLVEDDPKLARLIADFLE-SHGFNVVVEH-RGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPK-YQGPILLLTA 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17622   80 LDSDIDHILGLELGADDYVVKPVEPAVLLARLRA 113
pleD PRK09581
response regulator PleD; Reviewed
 9-121 2.10e-09

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 56.45  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRgvrqLLE---LDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI-- 83
Cdd:PRK09581   5 ILVVDDIPANVK----LLEaklLAEYYTVLT-ASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATTHIpv 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447036381  84 IILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:PRK09581  80 VMVTALDDPEDRVRGLEAGADDFLTKPINDVALFARVK 117
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 9-119 3.70e-09

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 52.44  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT- 87
Cdd:cd17563    3 LLLVDDDEVFAERLARALE-RRGFEVET-AHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTg 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  88 -VSDASSdVFAlIDAGADGYLLKDSDPEVLLEA 119
Cdd:cd17563   81 yASIATA-VEA-IKLGADDYLAKPADADEILAA 111
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-116 6.08e-09

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 55.24  E-value: 6.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   4 ATPFQVMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALR-RDGVTAQ 82
Cdd:PRK11361   2 TAINRILIVDDEDNVRRMLSTAFALQ-GFETHC-ANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRsHETRTPV 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  83 IIILTVSDASSDVFALIDaGADGYLLKDSDPEVL 116
Cdd:PRK11361  80 ILMTAYAEVETAVEALRC-GAFDYVIKPFDLDEL 112
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 9-123 7.33e-09

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 51.83  E-value: 7.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSV-GLAVKTFT-SASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFIT- 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447036381  89 sdASSDV---FALIDAGADGYLLKDSDPEVLLEAIRAG 123
Cdd:cd17537   80 --GHGDVpmaVEAMKAGAVDFLEKPFRDQVLLDAIEQA 115
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
9-136 1.68e-08

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 53.82  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRG-VRQLLELdpGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:PRK10841 804 ILVVDDHPINRRLlADQLGSL--GYQC-KTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGVT 880

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRagakgskVFSERVNQ 136
Cdd:PRK10841 881 ANALAEEKQRCLEAGMDSCLSKPVTLDVLKQTLT-------VYAERVRK 922
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 7-126 2.29e-08

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 50.87  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   7 FQVMIVDDHPLMRRGVRQLL--ELDPGFEVVAeagDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQII 84
Cdd:cd17575    1 IMVLLVDDQAIIGEAVRRALadEEDIDFHYCS---DPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATRDIP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 447036381  85 ILTVS-----DASSDVFALidaGADGYLLKDSDPEVLLEAIRAGAKG 126
Cdd:cd17575   78 IIVLStkeepEVKSEAFAL---GANDYLVKLPDKIELVARIRYHSRS 121
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 9-87 3.28e-08

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 50.19  E-value: 3.28e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:cd17550    1 ILIVDDEEDIRESLSGILE-DEGYEVDT-AADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIS 77
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 9-109 6.86e-08

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 49.14  E-value: 6.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ--IIIL 86
Cdd:cd17561    4 VLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMRLEKRpkIIML 83

                         90       100
                 ....*....|....*....|...
gi 447036381  87 TVSDASSDVFALIDAGADGYLLK 109
Cdd:cd17561   84 TAFGQEDITQRAVELGASYYILK 106
PRK11517 PRK11517
DNA-binding response regulator HprR;
8-122 8.78e-08

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 50.67  E-value: 8.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAqIIILT 87
Cdd:PRK11517   2 KILLIEDNQRTQEWVTQGLS-EAGY-VIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTP-VICLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:PRK11517  79 ARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRA 113
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 9-122 1.09e-07

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 48.60  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRER-GFDVTAAA-DGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISGD 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17594   80 RRDEIDRVVGLELGADDYLAKPFGLRELLARVRA 113
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 9-109 1.65e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 48.14  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVvAEAGDGASAIDLANRL---------DIDVILLDLNMKGMSGLDTLNALRRDGV 79
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLK-NLGFEI-AEAVDGEEALNKLENLakegndlskELDLIITDIEMPKMDGYELTFELRDDPR 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 447036381  80 TAQIIILTVSDASSDVFA--LIDAGADGYLLK 109
Cdd:cd19924   79 LANIPVILNSSLSGEFSRarGKKVGADAYLAK 110
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 9-120 2.78e-07

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 47.64  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELdPGFEVVAEAGDGASAIDLANRLDIDVILLDLNM-KGMSGLDTLNALRRDGVTAQ--III 85
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRS-LGVTRIDTASSGEEALRMCENKTYDIVLCDYNLgKGKNGQQLLEELRHKKLISPstVFI 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447036381  86 LTVSDAS-SDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:cd17589   80 MVTGESSrAMVLSALELEPDDYLLKPFTVSELRERL 115
PRK10766 PRK10766
two-component system response regulator TorR;
6-117 4.14e-07

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 48.88  E-value: 4.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   6 PFQVMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIII 85
Cdd:PRK10766   2 SYHILVVEDEPVTRARLQGYFEQE-GYTVS-EAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRS-TVGIIL 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLL 117
Cdd:PRK10766  79 VTGRTDSIDRIVGLEMGADDYVTKPLELRELL 110
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 9-116 4.85e-07

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 46.85  E-value: 4.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAeAGDGASAIDL--ANRLDIDVILLDLNMKGMSGLDTLNALrRDGVTAQIIIL 86
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRC-GYQVTT-CTDAEEALSMlrENKDEFDLVITDVHMPDMDGFEFLELI-RLEMDLPVIMM 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 447036381  87 TVSDASSDVFALIDAGADGYLLKDSDPEVL 116
Cdd:cd17584   78 SADGSTSTVMKGLAHGACDYLLKPVSIEDL 107
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 9-109 6.64e-07

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 48.26  E-value: 6.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAEAGDGASAIDLANRlDIDVILLDLNMKGMSGLDTLNALRRdGVTAQIIILTV 88
Cdd:PRK10529   4 VLIVEDEQAIRRFLRTALEGD-GMRVFEAETLQRGLLEAATR-KPDLIILDLGLPDGDGIEFIRDLRQ-WSAIPVIVLSA 80

                         90       100
                 ....*....|....*....|.
gi 447036381  89 SDASSDVFALIDAGADGYLLK 109
Cdd:PRK10529  81 RSEESDKIAALDAGADDYLSK 101
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 9-109 1.05e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 45.65  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIIILTV 88
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKE-GFEV-TVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARS-NVPVIMVTA 77

                         90       100
                 ....*....|....*....|.
gi 447036381  89 SDASSDVFALIDAGADGYLLK 109
Cdd:cd17621   78 KDSEIDKVVGLELGADDYVTK 98
PRK11173 PRK11173
two-component response regulator; Provisional
 5-122 1.11e-06

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 47.70  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   5 TPfQVMIVDDHPLMRRGVRQLLELDpGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAqII 84
Cdd:PRK11173   3 TP-HILIVEDELVTRNTLKSIFEAE-GYDVF-EATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVA-LM 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447036381  85 ILTVSDASSDVFALIDAGADGYLLKDSDPEVLleAIRA 122
Cdd:PRK11173  79 FLTGRDNEVDKILGLEIGADDYITKPFNPREL--TIRA 114
PRK15347 PRK15347
two component system sensor kinase;
8-124 1.12e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 48.48  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGV-RQLLELdpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLnALRRDGVTAQ---- 82
Cdd:PRK15347 692 QILLVDDVETNRDIIgMMLVEL--GQQVTT-AASGTEALELGRQHRFDLVLMDIRMPGLDGLETT-QLWRDDPNNLdpdc 767

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 447036381  83 -IIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGA 124
Cdd:PRK15347 768 mIVALTANAAPEEIHRCKKAGMNHYLTKPVTLAQLARALELAA 810
PRK10336 PRK10336
two-component system response regulator QseB;
8-196 1.20e-06

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 47.58  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLElDPGFEV--VAEAGDGASAIDLAnrlDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIII 85
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLS-KMGFSVdwFTQGRQGKEALYSA---PYDAVILDLTLPGMDGRDILREWREKGQREPVLI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKdsdPEVL------LEAIRAGAKGSKVFSERVNQY-LREREMFGAEEDPFSVLTERE 158
Cdd:PRK10336  78 LTARDALAERVEGLRLGADDYLCK---PFALievaarLEALMRRTNGQASNELRHGNVmLDPGKRIATLAGEPLTLKPKE 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 447036381 159 LDVLHELAQG----LSNKQIASVL-----NISEQTVKVHIRNLLRKL 196
Cdd:PRK10336 155 FALLELLMRNagrvLPRKLIEEKLytwdeEVTSNAVEVHVHHLRRKL 201
PRK15115 PRK15115
response regulator GlrR; Provisional
 5-120 1.70e-06

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 47.91  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   5 TPFQVMIVDDHP--LMRRGVRQLLEldpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ 82
Cdd:PRK15115   4 KPAHLLLVDDDPglLKLLGMRLTSE---GYSVVT-AESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMP 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447036381  83 IIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:PRK15115  80 VIILTAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAI 117
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 167-196 2.38e-06

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 46.02  E-value: 2.38e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 447036381  167 QGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:TIGR02985 128 EGLSNKEIAEELGISVKTVEYHITKALKFL 157
PRK10693 PRK10693
two-component system response regulator RssB;
36-109 3.02e-06

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 46.91  E-value: 3.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447036381  36 AEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGYLLK 109
Cdd:PRK10693   1 VLAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLK 74
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 9-109 3.10e-06

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 44.36  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIIILTV 88
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAE-GFSVETYT-DGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKS-TLPVIFLTS 77

                         90       100
                 ....*....|....*....|.
gi 447036381  89 SDASSDVFALIDAGADGYLLK 109
Cdd:cd19936   78 KDDEIDEVFGLRMGADDYITK 98
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 9-81 3.26e-06

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 44.55  E-value: 3.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNM-KGMSGLDTLNALRRDG------VTA 81
Cdd:cd17540    3 VLIIEDEPLIAMDLEQIVE-DLGHQVVGIARTRDEAVALARRERPDLILADIQLaDGSSGIDAVNEILTTHdvpvifVTA 81
PRK14084 PRK14084
DNA-binding response regulator;
8-109 3.37e-06

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 46.28  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:PRK14084   2 KALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFAT 81

                         90       100
                 ....*....|....*....|....
gi 447036381  88 vsdaSSDVFAL--IDAGADGYLLK 109
Cdd:PRK14084  82 ----AHDQFAVkaFELNATDYILK 101
PRK10430 PRK10430
two-component system response regulator DcuR;
9-109 3.61e-06

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 46.25  E-value: 3.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHP----LMRRGVRQLleldPGFEVVAEAG--DGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ 82
Cdd:PRK10430   4 VLIVDDDAmvaeLNRRYVAQI----PGFQCCGTAStlEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSD 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 447036381  83 IIILTvsdASSDVFALIDA---GADGYLLK 109
Cdd:PRK10430  80 VIVIS---SAADAATIKDSlhyGVVDYLIK 106
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 9-122 5.12e-06

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 43.90  E-value: 5.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVAEaGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDgVTAQIIILTV 88
Cdd:cd19939    2 ILIVEDELELARLTRDYLIKA-GLEVSVF-TDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREH-SHVPILMLTA 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 SDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd19939   79 RTEEMDRVLGLEMGADDYLCKPFSPRELLARVRA 112
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 9-104 7.46e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 43.10  E-value: 7.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAID-LANRLDIDVILLDLNMKG-MSGLDTLNALRRDGVTAQIIIL 86
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLE-DLGY-TVLEAASGDEALDlLESGPDIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLT 78

                         90
                 ....*....|....*...
gi 447036381  87 TVSDASSDVFALIDAGAD 104
Cdd:cd18161   79 SGYAENAIEGGDLAPGVD 96
PRK10188 PRK10188
transcriptional regulator SdiA;
140-197 1.09e-05

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 44.78  E-value: 1.09e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447036381 140 EREMFGAEEDPFSvltERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLN 197
Cdd:PRK10188 169 EDEMVMTPEMNFS---KREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFN 223
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 9-121 2.53e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 42.31  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--IIL 86
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILE-EQGYKVQV-ARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDLKDIpvILL 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  87 TVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17598   79 TTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIK 113
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 104-207 8.45e-05

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 42.04  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381 104 DGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQ--YLREREMFGAeedpfsvlTEREldVLHELAQGLSNKQIASVLNIS 181
Cdd:PRK11475  93 DGVLSKASTLEILQQELFLSLNGVRQATDRLNNqwYINQSRMLSP--------TERE--ILRFMSRGYSMPQIAEQLERN 162

                         90       100       110
                 ....*....|....*....|....*....|
gi 447036381 182 EQTVKVHIRNLLRKLNVRSRV----AATIL 207
Cdd:PRK11475 163 IKTIRAHKFNVMSKLGVSSDAglldAADIL 192
PRK06930 PRK06930
positive control sigma-like factor; Validated
 148-196 8.76e-05

positive control sigma-like factor; Validated


Pssm-ID: 180757 [Multi-domain]  Cd Length: 170  Bit Score: 41.64  E-value: 8.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 447036381 148 EDPFSVLTERELDV-LHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:PRK06930 109 EDALSVLTEREKEVyLMHRGYGLSYSEIADYLNIKKSTVQSMIERAEKKI 158
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 9-87 9.52e-05

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 40.64  E-value: 9.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLS-DEGYKV-THVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 156-196 1.24e-04

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 40.79  E-value: 1.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 447036381  156 ERELDVLHELaQGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:TIGR02937 115 EREVLVLRYL-EGLSYKEIAEILGISVGTVKRRLKRARKKL 154
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 156-196 1.33e-04

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 41.13  E-value: 1.33e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 447036381 156 ERELDVLHELaQGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:COG1595  132 QREVLVLRYL-EGLSYAEIAEILGISEGTVKSRLSRARKKL 171
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 156-196 1.37e-04

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 38.59  E-value: 1.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 447036381  156 ERELDVLHELaQGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:pfam08281  15 QREVFLLRYL-EGLSYAEIAELLGISEGTVKSRLSRARKKL 54
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 9-109 1.66e-04

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 39.41  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFeVVAEAGDGASAID-LANRLDIDVILLDLNMKGMSGLDTLNALRRdgVTAQIIILT 87
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLK-KAGY-AVTEAESGAEALEkLQQGKDIDIVVTDIVMPEMDGIELAREARK--IDPDVKILF 77

                         90       100
                 ....*....|....*....|...
gi 447036381  88 VSDASSDVFAL-IDAGADGYLLK 109
Cdd:cd18160   78 ISGGAAAAPELlSDAVGDNATLK 100
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 9-91 2.22e-04

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 39.73  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
Cdd:cd17530    3 VLVLDDDPFQCMMAATILE-DLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMSG 81


                 ...
gi 447036381  89 SDA 91
Cdd:cd17530   82 LDG 84
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 9-122 2.47e-04

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 39.33  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHplmrRGVRQLLELD---PGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAqIII 85
Cdd:cd17614    1 ILVVDDE----KPISDILKFNltkEGYEVVT-AYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVP-IIM 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd17614   75 LTAKDSEVDKVLGLELGADDYVTKPFSNRELLARVKA 111
PRK10816 PRK10816
two-component system response regulator PhoP;
8-109 2.47e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 40.88  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVR-QLLELdpGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86
Cdd:PRK10816   2 RVLVVEDNALLRHHLKvQLQDA--GHQVDA-AEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVL 78

                         90       100
                 ....*....|....*....|...
gi 447036381  87 TVSDASSDVFALIDAGADGYLLK 109
Cdd:PRK10816  79 TARESWQDKVEVLSAGADDYVTK 101
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 9-109 2.60e-04

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 38.89  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQ--IIIL 86
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLE-KQGFRVVV-IDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSALKDtpIIML 78

                         90       100
                 ....*....|....*....|...
gi 447036381  87 TVSDASSDVFALIDAGADGYLLK 109
Cdd:cd17602   79 TGKDGLVDRIRAKMAGASGYLTK 101
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
1-116 3.44e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 41.26  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381    1 MPEAtpFQVMIVDDHPLMRRGVRQLLELdPGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:PRK09959  955 LPEK--LSILIADDHPTNRLLLKRQLNL-LGYDV-DEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSS 1030

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 447036381   81 AQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVL 116
Cdd:PRK09959 1031 LPIWGLTANAQANEREKGLSCGMNLCLFKPLTLDVL 1066
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 9-109 5.32e-04

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 38.15  E-value: 5.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRL--DIDVILLDLNMKGMSGLDTLNALRRDGVTAQI--I 84
Cdd:cd17582    1 VLLVENDDSTRQIVTALLR-KCSYEVTA-ASDGLQAWDVLEDEqnEIDLILTEVDLPVSSGFKLLSYIMRHKICKNIpvI 78

                         90       100
                 ....*....|....*....|....*
gi 447036381  85 ILTVSDASSDVFALIDAGADGYLLK 109
Cdd:cd17582   79 MMSSQDSVGVVFKCLSKGAADYLVK 103
dpiA PRK10046
two-component response regulator DpiA; Provisional
 6-109 6.31e-04

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 39.62  E-value: 6.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   6 PFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIII 85
Cdd:PRK10046   4 PLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVF 83

                         90       100
                 ....*....|....*....|....
gi 447036381  86 LTVSDASSDVFALIDAGADGYLLK 109
Cdd:PRK10046  84 TTAASDMETVSEAVRCGVFDYLIK 107
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 8-112 6.54e-04

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 38.02  E-value: 6.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHplmrRGVRQLLEldpgfEVVAEAG-------DGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVT 80
Cdd:cd19919    2 TVWIVDDD----SSIRWVLE-----RALAGAGltvtsfeNAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPD 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  81 AQIIILTV-SDASSDVFALiDAGADGYLLKDSD 112
Cdd:cd19919   73 LPVIIMTAhSDLDSAVSAY-QGGAFEYLPKPFD 104
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 8-121 1.36e-03

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 37.15  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDhplmRRGVRQLLE---LDPGFEVVaEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQII 84
Cdd:cd17553    2 KILIVDD----QYGIRILLNevfNKEGYQTF-QAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447036381  85 ILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIR 121
Cdd:cd17553   77 IMTAYGELDMIQESKELGALTHFAKPFDIDEIRDAVK 113
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
156-195 1.75e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 35.10  E-value: 1.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 447036381  156 ERELDVLHELAQ--GLSNKQIASVLNISEQTVKVHIRNLLRK 195
Cdd:pfam13412   1 ETDRKILNLLQEnpRISQRELAERLGLSPSTVNRRLKRLEEE 42
PRK13719 PRK13719
conjugal transfer transcriptional regulator TraJ; Provisional
 154-208 2.15e-03

conjugal transfer transcriptional regulator TraJ; Provisional


Pssm-ID: 237479  Cd Length: 217  Bit Score: 37.79  E-value: 2.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447036381 154 LTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILF 208
Cdd:PRK13719 144 VTKYQNDVFILYSFGFSHEYIAQLLNITVGSSKNKISEILKFFGISSRDELLIIL 198
COG1356 COG1356
Transcriptional regulator [Transcription];
143-185 2.30e-03

Transcriptional regulator [Transcription];


Pssm-ID: 440967 [Multi-domain]  Cd Length: 139  Bit Score: 37.14  E-value: 2.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 447036381 143 MFGAEEdpfSVLTERELDVLHELAQGLSNKQIASVLNISEQTV 185
Cdd:COG1356    1 MFDAKY---SLLTRRQAEVLALRERGLTQQEIADILGTSRANV 40
Sigma70_r4 pfam04545
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 151-196 2.51e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.


Pssm-ID: 461347 [Multi-domain]  Cd Length: 50  Bit Score: 34.71  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 447036381  151 FSVLTERELDVLhELA--QGLSNKQIASVLNISEQTVKVHIRNLLRKL 196
Cdd:pfam04545   2 LASLPPRERQVL-VLRygEGLTLEEIGERLGISRERVRQIEKRALRKL 48
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 9-116 2.53e-03

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 38.19  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381    9 VMIVDDHPLMRRGVRQLLEldpGFEVVAeAGDGASAIDLANRLDIDVILLDL----NMKGMS-GLDTLNALRRDGVTAQI 83
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSFA---DYELAV-AADRESAIALVRRHEPAVVTLDLglppDADGASeGLAALQQILAIAPDTKV 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 447036381   84 IILTVSDASSDVFALIDAGADGYLLKDSDPEVL 116
Cdd:TIGR02915  77 IVITGNDDRENAVKAIGLGAYDFYQKPIDPDVL 109
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 8-122 2.70e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 37.63  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:PRK11083   5 TILLVEDEQAIADTLVYALQSE-GFTVEWFE-RGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLT 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:PRK11083  83 ARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRT 117
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 9-109 3.08e-03

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 36.19  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDpGFEVVA-EAG---------DGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDG 78
Cdd:cd17581    1 VLAVDDSLVDRKVIERLLRIS-SCRVTAvDSGkraleflglEDEEDSSNFNEPKVNMIITDYCMPGMTGYDLLKKVKESS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  79 VTAQIIILTVSdaSSDVFALI----DAGADGYLLK 109
Cdd:cd17581   80 ALKEIPVVIMS--SENIPTRIsrclEEGAEDFLLK 112
PRK12518 PRK12518
RNA polymerase sigma factor; Provisional
 154-215 4.21e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 237124 [Multi-domain]  Cd Length: 175  Bit Score: 36.62  E-value: 4.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447036381 154 LTERELDVLHELaQGLSNKQIASVLNISEQTVK---VHIRNLLRKlnvrsrvaatilFLQQRGAQ 215
Cdd:PRK12518 123 LEHRAVLVLHDL-EDLPQKEIAEILNIPVGTVKsrlFYARRQLRK------------FLQQQGVL 174
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 32-121 4.34e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 36.06  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381  32 FEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTvsdaSSDVFALI----DAGADGYL 107
Cdd:cd17533   33 IELTGKTEELLEKIKERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDPYAIIIFVT----THSEFAPLtfeyKVAALDFI 108

                         90
                 ....*....|....
gi 447036381 108 LKDSDPEVLLEAIR 121
Cdd:cd17533  109 LKPLKLEEFKKRIE 122
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
8-120 5.35e-03

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 37.32  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHpLMRRGVRQLLELDPGFEVvAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87
Cdd:PRK10365   7 DILVVDDD-ISHCTILQALLRGWGYNV-ALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMT 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAI 120
Cdd:PRK10365  85 AYSSVETAVEALKTGALDYLIKPLDFDNLQATL 117
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
159-194 7.02e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 34.94  E-value: 7.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 447036381 159 LDVLHELA-QGLSNKQIASVLNISEQTVKVHIRNLLR 194
Cdd:COG4189   22 LRILRLLAeEPLNVNELAEALGLPKSTVSYHIRKLEE 58
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 8-122 7.24e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 35.05  E-value: 7.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   8 QVMIVDDHPLMRRGVRQLLELDpGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGvTAQIIILT 87
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAA-GYAPTLLA-HGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFS-DVPIIMVT 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447036381  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
Cdd:cd19938   78 ARVEEIDRLLGLELGADDYICKPYSPREVVARVKA 112
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 9-113 8.05e-03

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 35.39  E-value: 8.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLELDPGFEV-VAEAGDGASAID----LANRLD-IDVILLDLNMKGMSGLDTLNALRRDGVTAQ 82
Cdd:cd17595    3 ILTVDDDPQVLRAVARDLRRQYGKDYrVLRADSGAEALDalkeLKLRGEaVALFLVDQRMPEMDGVEFLEKAMELFPEAK 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 447036381  83 IIILTV-SDASSDVFALIDAGADGYLLKDSDP 113
Cdd:cd17595   83 RVLLTAyADTDAAIRAINDVQLDYYLLKPWDP 114
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 9-117 8.22e-03

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 36.77  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447036381   9 VMIVDDHPLMRRGVRQLLElDPGFEVVAEAgDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTv 88
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALA-GAGLTCTTFE-NGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMT- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447036381  89 sdASSDVFALIDA---GADGYLLK--DSDPEVLL 117
Cdd:PRK10923  83 --AHSDLDAAVSAyqqGAFDYLPKpfDIDEAVAL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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