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Conserved domains on  [gi|447063366|ref|WP_001140622|]
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MULTISPECIES: XRE family transcriptional regulator [Gammaproteobacteria]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11466506)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 29-97 3.62e-10

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


:

Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 51.94  E-value: 3.62e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447063366  29 LETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMGGKLRIDVELPTGKHIG 97
Cdd:COG3620   18 LGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVLVVDDGKLVG 86
 
Name Accession Description Interval E-value
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 29-97 3.62e-10

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 51.94  E-value: 3.62e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447063366  29 LETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMGGKLRIDVELPTGKHIG 97
Cdd:COG3620   18 LGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVLVVDDGKLVG 86
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 8-89 1.77e-09

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 49.92  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447063366    8 LLASRSPESQARIQQMADELLletQLHLIREELEISQKELAATLGIKQPSLSAIEN-RGHDLKISTMKKYVEAMGGKLRI 86
Cdd:pfam13744   1 VFADLGFEDAEELQAKAQLAR---AIARLIEGRGLSQQEAAALLGIAQPKVSALLKgKLSRFSLDKLLDFLTALGQDVEI 77


                  ...
gi 447063366   87 DVE 89
Cdd:pfam13744  78 VVK 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
36-85 3.37e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 45.97  E-value: 3.37e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 447063366    36 IREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMGGKLR 85
Cdd:smart00530   5 LREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLD 54
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 32-81 6.52e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 42.54  E-value: 6.52e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 447063366  32 QLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:cd00093    3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALG 52
PRK09726 PRK09726
type II toxin-antitoxin system antitoxin HipB;
29-81 1.65e-04

type II toxin-antitoxin system antitoxin HipB;


Pssm-ID: 182049  Cd Length: 88  Bit Score: 37.27  E-value: 1.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 447063366  29 LETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:PRK09726  13 LANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLE 65
 
Name Accession Description Interval E-value
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 29-97 3.62e-10

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 51.94  E-value: 3.62e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447063366  29 LETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMGGKLRIDVELPTGKHIG 97
Cdd:COG3620   18 LGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVLVVDDGKLVG 86
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 8-89 1.77e-09

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 49.92  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447063366    8 LLASRSPESQARIQQMADELLletQLHLIREELEISQKELAATLGIKQPSLSAIEN-RGHDLKISTMKKYVEAMGGKLRI 86
Cdd:pfam13744   1 VFADLGFEDAEELQAKAQLAR---AIARLIEGRGLSQQEAAALLGIAQPKVSALLKgKLSRFSLDKLLDFLTALGQDVEI 77


                  ...
gi 447063366   87 DVE 89
Cdd:pfam13744  78 VVK 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
36-85 3.37e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 45.97  E-value: 3.37e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 447063366    36 IREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMGGKLR 85
Cdd:smart00530   5 LREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLD 54
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 32-81 6.52e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 42.54  E-value: 6.52e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 447063366  32 QLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:cd00093    3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALG 52
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 33-85 1.43e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 41.76  E-value: 1.43e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 447063366   33 LHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMGGKLR 85
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLD 53
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
29-81 3.51e-06

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 40.99  E-value: 3.51e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 447063366  29 LETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:COG1476    5 LGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALG 57
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
36-81 8.20e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 37.67  E-value: 8.20e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 447063366  36 IREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:COG1396   15 LRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALG 60
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 33-81 8.37e-05

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 37.27  E-value: 8.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 447063366   33 LHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:pfam12844   4 LRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLG 52
PRK09726 PRK09726
type II toxin-antitoxin system antitoxin HipB;
29-81 1.65e-04

type II toxin-antitoxin system antitoxin HipB;


Pssm-ID: 182049  Cd Length: 88  Bit Score: 37.27  E-value: 1.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 447063366  29 LETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:PRK09726  13 LANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLE 65
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 23-81 3.02e-03

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 33.37  E-value: 3.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447063366  23 MADELLLETQLHL------IREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAMG 81
Cdd:COG1813    1 MAKESTGELVEDYgerireAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALG 65
COG1709 COG1709
Predicted transcriptional regulator,contains XRE-type HTH domain [Transcription];
37-89 4.11e-03

Predicted transcriptional regulator,contains XRE-type HTH domain [Transcription];


Pssm-ID: 441315  Cd Length: 234  Bit Score: 34.77  E-value: 4.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 447063366  37 REELEISQKELAATLGIKQPSLSAIE-NRGHDLKISTMKKYVEAMggkLRIDVE 89
Cdd:COG1709   31 REDFGISQTELARELGVSPSVISDYEsGRRKSPGIAFVKKFVEAL---LEIDEE 81
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 32-63 4.36e-03

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 32.85  E-value: 4.36e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 447063366  32 QLHLIREELEISQKELAATLGIKQPSLSAIEN 63
Cdd:COG1426    9 LLRQAREAKGLSLEDVAERTKISVSYLEAIEE 40
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 26-63 7.77e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 32.47  E-value: 7.77e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 447063366  26 ELLLETQLhlirEELEISQKELAATLGIKQPSLSAIEN 63
Cdd:COG3093   11 EILREEFL----EPLGLSQTELAKALGVSRQRISEILN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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