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Conserved domains on  [gi|447170253|ref|WP_001247509|]
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MULTISPECIES: GBS Bsp-like repeat-containing protein [Streptococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C39A cd02549
A sub-family of peptidase family C39. Peptidase family C39 mostly contains ...
 703-832 1.93e-29

A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.


:

Pssm-ID: 239109 [Multi-domain]  Cd Length: 141  Bit Score: 114.04  E-value: 1.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 703 TLGETGCVPTSLAMILSSLKGETVLPTQIADylyHKTVEFNRGVQGTTSRGILK-AAKEWGVTATALGTQANLVQALKDG 781
Cdd:cd02549    1 PQLENGCGPTSLAMVLSYLGVKVTKPQLAAE---GNTYDFAKDGYGTYPKPIVSaAARKYGLVVRPLTGLLALLRQLAAG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 447170253 782 YHVLAAVQNNVFVLHGSHEIVLKGYN-NGLTHVSDPYTPSLsGWYPISQLWK 832
Cdd:cd02549   78 HPVIVSVNLGVSITPSGHAMVVIGYDrKGNVYVNDPGGGRR-LVVSFDEFEK 128
GBS_Bsp-like pfam08481
GBS Bsp-like repeat; This domain is found as a repeat in a number of Streptococcus proteins ...
 590-673 5.25e-21

GBS Bsp-like repeat; This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.


:

Pssm-ID: 400671  Cd Length: 89  Bit Score: 88.13  E-value: 5.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253  590 VQTTYKGTGNYNVRVTNVISPGNLK---IAIWSDKNNQDDLKWYTVTPKNHD-ATLTFNVTNHRDN-GKYFIHVYQENAS 664
Cdd:pfam08481   1 VQNYNANKGTFDVTVSGVSAPSGVKsvqVPVWSEANGQDDLKWYTATKQSDGtYKVTVNIKNHKNEtGTYNVHAYVTDTN 80


                  ....*....
gi 447170253  665 NQKQLLVKT 673
Cdd:pfam08481  81 GKQKFLGAT 89
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 548-581 1.36e-13

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 65.07  E-value: 1.36e-13
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  548 HMQDYGWQDWTYNNDIAGSTNQGKRIEAIEIKLV 581
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 396-429 1.34e-12

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 62.38  E-value: 1.34e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  396 HVQDKGWMAWQKNNSVAGTVGESKRLEALEVKLV 429
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 249-282 6.89e-11

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 57.37  E-value: 6.89e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  249 HVQDIGWMAWAKNGAYAGTLEMSKRLEAYEVKFT 282
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 155-188 5.61e-09

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 51.98  E-value: 5.61e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  155 HVQDIGWQKSVDNATVSGTVGQEKQVEAIKLSIK 188
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 202-236 9.15e-09

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 51.59  E-value: 9.15e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 447170253  202 YVKGQGWQSSVESGQVSGTVGQSKPIEALSINLTD 236
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLTG 35
KxYKxGKxW_sig pfam19258
KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as ...
 5-40 3.36e-05

KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK signal peptide.


:

Pssm-ID: 466014 [Multi-domain]  Cd Length: 41  Bit Score: 41.71  E-value: 3.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 447170253    5 VRKKMYKKGKFWVIAGI--VTILGGSAIIGQDVKAEQA 40
Cdd:pfam19258   4 THYKMYKSGKHWVFAGIttLGLGLGLLGGTTAAAADAT 41
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 351-383 3.46e-04

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 38.50  E-value: 3.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 447170253  351 HVQDKGW------GEILGSQTskdyQGKRLEAIQLDLSG 383
Cdd:pfam07538   1 HVQNIGWqdwvknGEIAGTTG----QGLRLEAIKIKLTG 35
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 309-339 8.89e-03

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


:

Pssm-ID: 429523  Cd Length: 35  Bit Score: 34.64  E-value: 8.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 447170253  309 QN-GWQSNKLEGQMAGTLGESKALDGVKFTLS 339
Cdd:pfam07538   3 QNiGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
 
Name Accession Description Interval E-value
Peptidase_C39A cd02549
A sub-family of peptidase family C39. Peptidase family C39 mostly contains ...
 703-832 1.93e-29

A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.


Pssm-ID: 239109 [Multi-domain]  Cd Length: 141  Bit Score: 114.04  E-value: 1.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 703 TLGETGCVPTSLAMILSSLKGETVLPTQIADylyHKTVEFNRGVQGTTSRGILK-AAKEWGVTATALGTQANLVQALKDG 781
Cdd:cd02549    1 PQLENGCGPTSLAMVLSYLGVKVTKPQLAAE---GNTYDFAKDGYGTYPKPIVSaAARKYGLVVRPLTGLLALLRQLAAG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 447170253 782 YHVLAAVQNNVFVLHGSHEIVLKGYN-NGLTHVSDPYTPSLsGWYPISQLWK 832
Cdd:cd02549   78 HPVIVSVNLGVSITPSGHAMVVIGYDrKGNVYVNDPGGGRR-LVVSFDEFEK 128
GBS_Bsp-like pfam08481
GBS Bsp-like repeat; This domain is found as a repeat in a number of Streptococcus proteins ...
 590-673 5.25e-21

GBS Bsp-like repeat; This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.


Pssm-ID: 400671  Cd Length: 89  Bit Score: 88.13  E-value: 5.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253  590 VQTTYKGTGNYNVRVTNVISPGNLK---IAIWSDKNNQDDLKWYTVTPKNHD-ATLTFNVTNHRDN-GKYFIHVYQENAS 664
Cdd:pfam08481   1 VQNYNANKGTFDVTVSGVSAPSGVKsvqVPVWSEANGQDDLKWYTATKQSDGtYKVTVNIKNHKNEtGTYNVHAYVTDTN 80


                  ....*....
gi 447170253  665 NQKQLLVKT 673
Cdd:pfam08481  81 GKQKFLGAT 89
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 548-581 1.36e-13

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 65.07  E-value: 1.36e-13
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  548 HMQDYGWQDWTYNNDIAGSTNQGKRIEAIEIKLV 581
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 396-429 1.34e-12

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 62.38  E-value: 1.34e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  396 HVQDKGWMAWQKNNSVAGTVGESKRLEALEVKLV 429
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 249-282 6.89e-11

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 57.37  E-value: 6.89e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  249 HVQDIGWMAWAKNGAYAGTLEMSKRLEAYEVKFT 282
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
547-595 5.57e-10

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 55.34  E-value: 5.57e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 447170253   547 VHMQDYGWQDWTYNNDIAGSTNQGKRIEAIEIKLVetaKIPITVQTTYK 595
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLV---NAPAGASIQYQ 46
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 155-188 5.61e-09

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 51.98  E-value: 5.61e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  155 HVQDIGWQKSVDNATVSGTVGQEKQVEAIKLSIK 188
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 202-236 9.15e-09

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 51.59  E-value: 9.15e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 447170253  202 YVKGQGWQSSVESGQVSGTVGQSKPIEALSINLTD 236
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLTG 35
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
395-438 9.25e-09

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 51.88  E-value: 9.25e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 447170253   395 AHVQDKGWMAWQKNNSVAGTVGESKRLEALEVKLVAKASDFSSQ 438
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLVNAPAGASIQ 44
Peptidase_C39_2 pfam13529
Peptidase_C39 like family;
683-816 1.57e-08

Peptidase_C39 like family;


Pssm-ID: 379241 [Multi-domain]  Cd Length: 139  Bit Score: 53.99  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253  683 NTPYFSQRDGrwasrrygmatlGETGCVPTSLAMILSSLkGETVLPTQIAD-YLYHKTVEFNRGVQGT----TSRG---- 753
Cdd:pfam13529   1 DVPYYNQLDE------------LPNGCGPTSLAMVLSYL-GITVTQDELAKeIGTNPDGNPNTGFVGNpydkSGYGvynp 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447170253  754 -ILKAAKEWGVTATALGTQ--ANLVQALKDGYHVLAAVQN----NVFVLHGSHEIVLKGY--NNGLTHVSDP 816
Cdd:pfam13529  68 pIVALAEKYGLKVTDITGSsfDEVIRLLDAGIPVVVSTTTfgplNYYFTSSGHLVVIVGYddKGDYVYVNDP 139
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
201-247 1.80e-08

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 51.10  E-value: 1.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 447170253   201 TYVKGQGWQSSVESGQVSGTVGQSKPIEALSINLTDNLQKlYDVYYR 247
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLVNAPAG-ASIQYQ 46
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
154-192 3.15e-07

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 47.64  E-value: 3.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 447170253   154 AHVQDIGWQKSVDNATVSGTVGQEKQVEAIKLSI-KAPEG 192
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLvNAPAG 40
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
248-280 5.84e-07

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 46.87  E-value: 5.84e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 447170253   248 VHVQDIGWMAWAKNGAYAGTLEMSKRLEAYEVK 280
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKIN 33
KxYKxGKxW_sig pfam19258
KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as ...
 5-40 3.36e-05

KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK signal peptide.


Pssm-ID: 466014 [Multi-domain]  Cd Length: 41  Bit Score: 41.71  E-value: 3.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 447170253    5 VRKKMYKKGKFWVIAGI--VTILGGSAIIGQDVKAEQA 40
Cdd:pfam19258   4 THYKMYKSGKHWVFAGIttLGLGLGLLGGTTAAAADAT 41
YvpB COG4990
Predicted cysteine peptidase, C39 family [General function prediction only];
653-841 1.54e-04

Predicted cysteine peptidase, C39 family [General function prediction only];


Pssm-ID: 444014 [Multi-domain]  Cd Length: 303  Bit Score: 44.80  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 653 KYFIHVYQENASNQKQLLVKTSLQVAHSNYNTPYFSQRDGRWasrrygmatlgeTGCVPTSLAMILSSlKGETVLPTQIA 732
Cdd:COG4990   87 AVRVSLTGELPAPGMKKIIYPKPNPDSVLLNVPYISQLPELP------------TGCEVTSLAMLLNY-YGIDVTKDELA 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 733 DYL-YHKTVE------FNRGVQGTTSRG----------ILKAAKEWG---VTATALGTQANLVQALKDGYHVLAAVQNNV 792
Cdd:COG4990  154 EYLpKVPLPYngyggnPNKGFVGDPYGSdpgygvyappIAQLAKKYLpgkAVDLTGASFEDILDELASGNPVIVWTTLDF 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447170253 793 FVLHGS-----------------HEIVLKGYNNGLTHVSDPYTPSLSGWYPISQLwkEQSYYSEDR 841
Cdd:COG4990  234 SPPSAFrswttpdgktfdftaneHAVVVTGYDDEGVYVNDPLGGNKYVKYSRSLF--ERSWEQMGK 297
KxYKxGKxW TIGR03715
KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as ...
 5-25 1.69e-04

KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK and PEP-CTERM forms of signal peptide. This domain tends to occur on long, low-complexity (usually Serine-rich and heavily glycosylated) proteins of the Firmicutes, and (as with YSIRK) the majority of these proteins have the LPXTG cell wall-anchoring motif at the C-terminus.


Pssm-ID: 274741 [Multi-domain]  Cd Length: 23  Bit Score: 39.29  E-value: 1.69e-04
                          10        20
                  ....*....|....*....|.
gi 447170253    5 VRKKMYKKGKFWVIAGIVTIL 25
Cdd:TIGR03715   2 KRYKMYKSGKHWVFAGIATLA 22
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 351-383 3.46e-04

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 38.50  E-value: 3.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 447170253  351 HVQDKGW------GEILGSQTskdyQGKRLEAIQLDLSG 383
Cdd:pfam07538   1 HVQNIGWqdwvknGEIAGTTG----QGLRLEAIKIKLTG 35
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 309-339 8.89e-03

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 34.64  E-value: 8.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 447170253  309 QN-GWQSNKLEGQMAGTLGESKALDGVKFTLS 339
Cdd:pfam07538   3 QNiGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
 
Name Accession Description Interval E-value
Peptidase_C39A cd02549
A sub-family of peptidase family C39. Peptidase family C39 mostly contains ...
 703-832 1.93e-29

A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.


Pssm-ID: 239109 [Multi-domain]  Cd Length: 141  Bit Score: 114.04  E-value: 1.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 703 TLGETGCVPTSLAMILSSLKGETVLPTQIADylyHKTVEFNRGVQGTTSRGILK-AAKEWGVTATALGTQANLVQALKDG 781
Cdd:cd02549    1 PQLENGCGPTSLAMVLSYLGVKVTKPQLAAE---GNTYDFAKDGYGTYPKPIVSaAARKYGLVVRPLTGLLALLRQLAAG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 447170253 782 YHVLAAVQNNVFVLHGSHEIVLKGYN-NGLTHVSDPYTPSLsGWYPISQLWK 832
Cdd:cd02549   78 HPVIVSVNLGVSITPSGHAMVVIGYDrKGNVYVNDPGGGRR-LVVSFDEFEK 128
GBS_Bsp-like pfam08481
GBS Bsp-like repeat; This domain is found as a repeat in a number of Streptococcus proteins ...
 590-673 5.25e-21

GBS Bsp-like repeat; This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.


Pssm-ID: 400671  Cd Length: 89  Bit Score: 88.13  E-value: 5.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253  590 VQTTYKGTGNYNVRVTNVISPGNLK---IAIWSDKNNQDDLKWYTVTPKNHD-ATLTFNVTNHRDN-GKYFIHVYQENAS 664
Cdd:pfam08481   1 VQNYNANKGTFDVTVSGVSAPSGVKsvqVPVWSEANGQDDLKWYTATKQSDGtYKVTVNIKNHKNEtGTYNVHAYVTDTN 80


                  ....*....
gi 447170253  665 NQKQLLVKT 673
Cdd:pfam08481  81 GKQKFLGAT 89
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 548-581 1.36e-13

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 65.07  E-value: 1.36e-13
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  548 HMQDYGWQDWTYNNDIAGSTNQGKRIEAIEIKLV 581
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 396-429 1.34e-12

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 62.38  E-value: 1.34e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  396 HVQDKGWMAWQKNNSVAGTVGESKRLEALEVKLV 429
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 249-282 6.89e-11

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 57.37  E-value: 6.89e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  249 HVQDIGWMAWAKNGAYAGTLEMSKRLEAYEVKFT 282
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
547-595 5.57e-10

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 55.34  E-value: 5.57e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 447170253   547 VHMQDYGWQDWTYNNDIAGSTNQGKRIEAIEIKLVetaKIPITVQTTYK 595
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLV---NAPAGASIQYQ 46
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 155-188 5.61e-09

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 51.98  E-value: 5.61e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 447170253  155 HVQDIGWQKSVDNATVSGTVGQEKQVEAIKLSIK 188
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 202-236 9.15e-09

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 51.59  E-value: 9.15e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 447170253  202 YVKGQGWQSSVESGQVSGTVGQSKPIEALSINLTD 236
Cdd:pfam07538   1 HVQNIGWQDWVKNGEIAGTTGQGLRLEAIKIKLTG 35
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
395-438 9.25e-09

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 51.88  E-value: 9.25e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 447170253   395 AHVQDKGWMAWQKNNSVAGTVGESKRLEALEVKLVAKASDFSSQ 438
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLVNAPAGASIQ 44
Peptidase_C39_2 pfam13529
Peptidase_C39 like family;
683-816 1.57e-08

Peptidase_C39 like family;


Pssm-ID: 379241 [Multi-domain]  Cd Length: 139  Bit Score: 53.99  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253  683 NTPYFSQRDGrwasrrygmatlGETGCVPTSLAMILSSLkGETVLPTQIAD-YLYHKTVEFNRGVQGT----TSRG---- 753
Cdd:pfam13529   1 DVPYYNQLDE------------LPNGCGPTSLAMVLSYL-GITVTQDELAKeIGTNPDGNPNTGFVGNpydkSGYGvynp 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447170253  754 -ILKAAKEWGVTATALGTQ--ANLVQALKDGYHVLAAVQN----NVFVLHGSHEIVLKGY--NNGLTHVSDP 816
Cdd:pfam13529  68 pIVALAEKYGLKVTDITGSsfDEVIRLLDAGIPVVVSTTTfgplNYYFTSSGHLVVIVGYddKGDYVYVNDP 139
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
201-247 1.80e-08

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 51.10  E-value: 1.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 447170253   201 TYVKGQGWQSSVESGQVSGTVGQSKPIEALSINLTDNLQKlYDVYYR 247
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLVNAPAG-ASIQYQ 46
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
154-192 3.15e-07

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 47.64  E-value: 3.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 447170253   154 AHVQDIGWQKSVDNATVSGTVGQEKQVEAIKLSI-KAPEG 192
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKINLvNAPAG 40
ChW smart00728
Clostridial hydrophobic, with a conserved W residue, domain;
248-280 5.84e-07

Clostridial hydrophobic, with a conserved W residue, domain;


Pssm-ID: 214791  Cd Length: 46  Bit Score: 46.87  E-value: 5.84e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 447170253   248 VHVQDIGWMAWAKNGAYAGTLEMSKRLEAYEVK 280
Cdd:smart00728   1 AHVQNIGWQNWVSDGAIAGTVGQGLRIEAIKIN 33
Peptidase_C39 pfam03412
Peptidase C39 family; Lantibiotic and non-lantibiotic bacteriocins are synthesized as ...
 706-816 7.18e-06

Peptidase C39 family; Lantibiotic and non-lantibiotic bacteriocins are synthesized as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP-binding cassette (ABC) transporter. The ABC transporter is the maturation protease and its proteolytic domain resides in the N-terminal part of the protein. This peptidase domain is found in a wide range of ABC transporters, however the presumed catalytic cysteine and histidine are not conserved in all members of this family.


Pssm-ID: 367483 [Multi-domain]  Cd Length: 133  Bit Score: 46.06  E-value: 7.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253  706 ETGCVPTSLAMILSSLKGETVLptqiaDYLYHKtveFNRGVQGTTSRGILKAAKEWGVTATALgtQANLvQALKDgyhvl 785
Cdd:pfam03412  10 ENDCGLACLAMILKYYGSNVSL-----EELREL---AGTPAEGTSLLGLKKAAEKLGFKAKAI--KADL-SELKE----- 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 447170253  786 aavQNNVFVLH----GSHEIVLKGYNNGLTHVSDP 816
Cdd:pfam03412  74 ---LPLPFIAHwdgnGGHFVVVYGIKKNKVLIADP 105
KxYKxGKxW_sig pfam19258
KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as ...
 5-40 3.36e-05

KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK signal peptide.


Pssm-ID: 466014 [Multi-domain]  Cd Length: 41  Bit Score: 41.71  E-value: 3.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 447170253    5 VRKKMYKKGKFWVIAGI--VTILGGSAIIGQDVKAEQA 40
Cdd:pfam19258   4 THYKMYKSGKHWVFAGIttLGLGLGLLGGTTAAAADAT 41
YvpB COG4990
Predicted cysteine peptidase, C39 family [General function prediction only];
653-841 1.54e-04

Predicted cysteine peptidase, C39 family [General function prediction only];


Pssm-ID: 444014 [Multi-domain]  Cd Length: 303  Bit Score: 44.80  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 653 KYFIHVYQENASNQKQLLVKTSLQVAHSNYNTPYFSQRDGRWasrrygmatlgeTGCVPTSLAMILSSlKGETVLPTQIA 732
Cdd:COG4990   87 AVRVSLTGELPAPGMKKIIYPKPNPDSVLLNVPYISQLPELP------------TGCEVTSLAMLLNY-YGIDVTKDELA 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170253 733 DYL-YHKTVE------FNRGVQGTTSRG----------ILKAAKEWG---VTATALGTQANLVQALKDGYHVLAAVQNNV 792
Cdd:COG4990  154 EYLpKVPLPYngyggnPNKGFVGDPYGSdpgygvyappIAQLAKKYLpgkAVDLTGASFEDILDELASGNPVIVWTTLDF 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447170253 793 FVLHGS-----------------HEIVLKGYNNGLTHVSDPYTPSLSGWYPISQLwkEQSYYSEDR 841
Cdd:COG4990  234 SPPSAFrswttpdgktfdftaneHAVVVTGYDDEGVYVNDPLGGNKYVKYSRSLF--ERSWEQMGK 297
KxYKxGKxW TIGR03715
KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as ...
 5-25 1.69e-04

KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK and PEP-CTERM forms of signal peptide. This domain tends to occur on long, low-complexity (usually Serine-rich and heavily glycosylated) proteins of the Firmicutes, and (as with YSIRK) the majority of these proteins have the LPXTG cell wall-anchoring motif at the C-terminus.


Pssm-ID: 274741 [Multi-domain]  Cd Length: 23  Bit Score: 39.29  E-value: 1.69e-04
                          10        20
                  ....*....|....*....|.
gi 447170253    5 VRKKMYKKGKFWVIAGIVTIL 25
Cdd:TIGR03715   2 KRYKMYKSGKHWVFAGIATLA 22
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 351-383 3.46e-04

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 38.50  E-value: 3.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 447170253  351 HVQDKGW------GEILGSQTskdyQGKRLEAIQLDLSG 383
Cdd:pfam07538   1 HVQNIGWqdwvknGEIAGTTG----QGLRLEAIKIKLTG 35
ChW pfam07538
Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based ...
 309-339 8.89e-03

Clostridial hydrophobic W; A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.


Pssm-ID: 429523  Cd Length: 35  Bit Score: 34.64  E-value: 8.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 447170253  309 QN-GWQSNKLEGQMAGTLGESKALDGVKFTLS 339
Cdd:pfam07538   3 QNiGWQDWVKNGEIAGTTGQGLRLEAIKIKLT 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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