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Conserved domains on  [gi|447172053|ref|WP_001249309|]
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zinc-dependent transcriptional regulator AdcR [Streptococcus pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdcR_fam_Zn_TF NF038251
zinc-dependent MarR family transcriptional regulator; This HMM represents one of several ...
 3-145 5.05e-74

zinc-dependent MarR family transcriptional regulator; This HMM represents one of several unusual clades within the MarR family transcription factors that bind Zn(2+) and regulate the response to zinc abundance or scarcity. Members include AdcR (adhesin competence regulator), which regulates expression of the high affinity zinc uptake transporter AdcABC and various other proteins.


:

Pssm-ID: 439551  Cd Length: 143  Bit Score: 217.53  E-value: 5.05e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053   3 QLAKDIDAFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:NF038251   1 ELAQQIDQFLNQILLKAENQHELLIGKCQSDVKLTNTQEHILMLLSEERLTNSDLAKKLNVSQAAVTKAVKSLVKQGMLE 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447172053  83 TSKDSKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEI 145
Cdd:NF038251  81 SVKDKKDARVTYYSLTELAKPIAEEHEHHHQHTLSVYDELLDQFSDEEQEVISRFLDALSEEL 143
 
Name Accession Description Interval E-value
AdcR_fam_Zn_TF NF038251
zinc-dependent MarR family transcriptional regulator; This HMM represents one of several ...
 3-145 5.05e-74

zinc-dependent MarR family transcriptional regulator; This HMM represents one of several unusual clades within the MarR family transcription factors that bind Zn(2+) and regulate the response to zinc abundance or scarcity. Members include AdcR (adhesin competence regulator), which regulates expression of the high affinity zinc uptake transporter AdcABC and various other proteins.


Pssm-ID: 439551  Cd Length: 143  Bit Score: 217.53  E-value: 5.05e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053   3 QLAKDIDAFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:NF038251   1 ELAQQIDQFLNQILLKAENQHELLIGKCQSDVKLTNTQEHILMLLSEERLTNSDLAKKLNVSQAAVTKAVKSLVKQGMLE 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447172053  83 TSKDSKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEI 145
Cdd:NF038251  81 SVKDKKDARVTYYSLTELAKPIAEEHEHHHQHTLSVYDELLDQFSDEEQEVISRFLDALSEEL 143
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-141 1.70e-15

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 68.46  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053   1 MRQLAKDIDAFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEG 79
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEaGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447172053  80 MLETSKDSKDARVIFYQLTDLARPIAEEHHHHHEHTLltyEQVATQFTPNEQKVIQRFLTAL 141
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALL---AELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-131 2.04e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.54  E-value: 2.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053    36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLARPIAEEHHHHHEH 114
Cdd:smart00347   8 LTPTQFLVLRILYEeGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....*..
gi 447172053   115 tllTYEQVATQFTPNEQ 131
Cdd:smart00347  88 ---TLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-93 7.45e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 56.79  E-value: 7.45e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 447172053   36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVI 93
Cdd:pfam01047   1 LTLTQFHILRILYEhGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 43-102 7.84e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 54.61  E-value: 7.84e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSkdaRVIFYQLTDLAR 102
Cdd:cd00090   12 ILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTDAER 68
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 43-99 1.55e-06

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 43.22  E-value: 1.55e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETskdSKDARVIFYQLTD 99
Cdd:NF033788  16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTS---RREGRWVYYRLAD 69
PRK09775 PRK09775
type II toxin-antitoxin system HipA family toxin YjjJ;
43-105 6.98e-04

type II toxin-antitoxin system HipA family toxin YjjJ;


Pssm-ID: 236623 [Multi-domain]  Cd Length: 442  Bit Score: 38.41  E-value: 6.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSL----VKEGmletskdskDARVIFYQLTDLARPIA 105
Cdd:PRK09775   5 LTTLLLQGPLSAAELAARLGVSQATLSRLLAALgdqvVRFG---------KARATRYALLRPLRGVS 62
 
Name Accession Description Interval E-value
AdcR_fam_Zn_TF NF038251
zinc-dependent MarR family transcriptional regulator; This HMM represents one of several ...
 3-145 5.05e-74

zinc-dependent MarR family transcriptional regulator; This HMM represents one of several unusual clades within the MarR family transcription factors that bind Zn(2+) and regulate the response to zinc abundance or scarcity. Members include AdcR (adhesin competence regulator), which regulates expression of the high affinity zinc uptake transporter AdcABC and various other proteins.


Pssm-ID: 439551  Cd Length: 143  Bit Score: 217.53  E-value: 5.05e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053   3 QLAKDIDAFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:NF038251   1 ELAQQIDQFLNQILLKAENQHELLIGKCQSDVKLTNTQEHILMLLSEERLTNSDLAKKLNVSQAAVTKAVKSLVKQGMLE 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447172053  83 TSKDSKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEI 145
Cdd:NF038251  81 SVKDKKDARVTYYSLTELAKPIAEEHEHHHQHTLSVYDELLDQFSDEEQEVISRFLDALSEEL 143
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-141 1.70e-15

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 68.46  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053   1 MRQLAKDIDAFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEG 79
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEaGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447172053  80 MLETSKDSKDARVIFYQLTDLARPIAEEHHHHHEHTLltyEQVATQFTPNEQKVIQRFLTAL 141
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALL---AELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-131 2.04e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.54  E-value: 2.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053    36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLARPIAEEHHHHHEH 114
Cdd:smart00347   8 LTPTQFLVLRILYEeGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....*..
gi 447172053   115 tllTYEQVATQFTPNEQ 131
Cdd:smart00347  88 ---TLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-93 7.45e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 56.79  E-value: 7.45e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 447172053   36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVI 93
Cdd:pfam01047   1 LTLTQFHILRILYEhGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 43-102 7.84e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 54.61  E-value: 7.84e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSkdaRVIFYQLTDLAR 102
Cdd:cd00090   12 ILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
43-99 9.58e-11

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 54.14  E-value: 9.58e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053    43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETskdSKDARVIFYQLTD 99
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVES---RREGKRVYYSLTD 55
HTH_27 pfam13463
Winged helix DNA-binding domain;
31-99 2.06e-08

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 48.05  E-value: 2.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447172053   31 TSEVALTNtqeHILMLLSEESLtnSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTD 99
Cdd:pfam13463   3 RLEALILH---NIGHRGDPKTL--ADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTA 66
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-91 2.13e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.97  E-value: 2.13e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053   36 LTNTQEHILM-LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDAR 91
Cdd:pfam12802   3 LTPAQFRVLLaLARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
36-105 4.03e-08

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 49.05  E-value: 4.03e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447172053  36 LTNTQEHILM---LLSEE--SLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKdarvifYQLTDLARPIA 105
Cdd:COG1321    4 LSESEEDYLKaiyELSEEggPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG------ITLTEEGRELA 72
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
43-99 4.13e-08

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 47.96  E-value: 4.13e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETskdSKDARVIFYQLTD 99
Cdd:COG0640   25 ILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTS---RREGRWVYYRLAD 78
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 43-99 1.55e-06

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 43.22  E-value: 1.55e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETskdSKDARVIFYQLTD 99
Cdd:NF033788  16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTS---RREGRWVYYRLAD 69
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
43-105 9.65e-06

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 43.73  E-value: 9.65e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSkdarvifYQLTDLARPIA 105
Cdd:COG4742   21 ILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERDDGE-------YELTTLGRLVV 76
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
39-81 4.80e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.57  E-value: 4.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 447172053   39 TQEHILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGML 81
Cdd:pfam13412   2 TDRKILNLLQENPrISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
34-82 5.88e-05

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 40.53  E-value: 5.88e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 447172053  34 VALTNTQEHILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:COG1522    1 MELDEIDRRILRLLQEDGrLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 43-81 6.25e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 6.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 447172053   43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGML 81
Cdd:pfam01022   7 ILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 46-88 9.09e-05

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 38.27  E-value: 9.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 447172053   46 LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSK 88
Cdd:pfam01978  17 LLKLGPATADEIAEESGVPRSKVYEVLRSLEDKGLVEREKGRP 59
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
39-103 1.19e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.29  E-value: 1.19e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447172053  39 TQEHILMLLSEE-SLTNSELARRLNVSQAAVTKAIKSLVKEGMLEtSKDSKDAR---VIFYQLTDLARP 103
Cdd:COG2345   14 TRRRILELLKRAgPVTAAELAEALGLTPNAVRRHLDALEEEGLVE-RETERRGRgrpAKLYRLTEAGRA 81
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 42-82 1.31e-04

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 39.04  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 447172053    42 HILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:smart00344   7 KILEELQKDArISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 41-87 2.99e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 447172053   41 EHILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDS 87
Cdd:pfam01325   8 ETIYTLSEEKGvVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYK 55
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 54-105 3.27e-04

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 37.58  E-value: 3.27e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 447172053    54 NSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKdarvifYQLTDLARPIA 105
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRG------ITLTEKGRRLA 46
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
42-99 3.37e-04

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 38.76  E-value: 3.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447172053  42 HILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDaRVIFYQLTD 99
Cdd:COG1510   33 YALLYLSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGD-RKDYFRAEK 89
BirA COG1654
Biotin operon repressor [Transcription];
36-79 5.67e-04

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 38.81  E-value: 5.67e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 447172053  36 LTNTQEHILMLLS-EESLTNSELARRLNVSQAAVTKAIKSLVKEG 79
Cdd:COG1654    2 MSSTRLKLLRLLAdGEFHSGEELAEELGVSRAAVWKHIKALRELG 46
PRK09775 PRK09775
type II toxin-antitoxin system HipA family toxin YjjJ;
43-105 6.98e-04

type II toxin-antitoxin system HipA family toxin YjjJ;


Pssm-ID: 236623 [Multi-domain]  Cd Length: 442  Bit Score: 38.41  E-value: 6.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSL----VKEGmletskdskDARVIFYQLTDLARPIA 105
Cdd:PRK09775   5 LTTLLLQGPLSAAELAARLGVSQATLSRLLAALgdqvVRFG---------KARATRYALLRPLRGVS 62
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 56-83 9.36e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 35.50  E-value: 9.36e-04
                         10        20
                 ....*....|....*....|....*...
gi 447172053  56 ELARRLNVSQAAVTKAIKSLVKEGMLET 83
Cdd:cd07377   30 ELAEELGVSRTTVREALRELEAEGLVER 57
RPA_C pfam08784
Replication protein A C terminal; This domain corresponds to the C terminal of the single ...
 35-86 2.06e-03

Replication protein A C terminal; This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.


Pssm-ID: 400920  Cd Length: 106  Bit Score: 35.82  E-value: 2.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 447172053   35 ALTNTQEHILMLL-----SEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKD 86
Cdd:pfam08784  48 GLTPLQDQVLNLIkqppnGNEGVHVDEIAQRLGLPVNDVKQAVDFLSNEGHIYSTID 104
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 41-80 2.78e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 33.95  E-value: 2.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 447172053   41 EHILMLL--SEESLTNSELARRLNVSQAAVTKAIKSLVKEGM 80
Cdd:pfam08279   1 LQILQLLleARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
56-82 3.09e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 36.38  E-value: 3.09e-03
                         10        20
                 ....*....|....*....|....*..
gi 447172053  56 ELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:COG2188   34 ELAEEFGVSRMTVRKALDELVEEGLLE 60
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
43-98 4.20e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 35.95  E-value: 4.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447172053  43 ILMLLSE--ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLEtsKDSKDARvifYQLT 98
Cdd:COG1414   14 ILEALAEagGGLSLSELARRLGLPKSTVHRLLATLEEEGYVE--RDPEGGR---YRLG 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 46-88 6.95e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 33.28  E-value: 6.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 447172053   46 LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSK 88
Cdd:pfam12840  19 LVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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