|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
7-389 |
0e+00 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 530.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDIV-HSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVgDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLA 165
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 166 AAVLNGLNLLLGCFLMQESHKGERRPMPL-RAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWS 244
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 245 ATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAML 324
Cdd:cd17388 241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 325 SRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALRRGA 389
Cdd:cd17388 321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-380 |
1.59e-66 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 214.75 E-value: 1.59e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 10 ILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAI 89
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 90 MATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI-SLHAPFLAAAV 168
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPyGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 169 lnglnlllgcflmqeshkgerrpmpLRAFNPVSSFRWargMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMI 248
Cdd:cd17330 161 -------------------------LALLNLVLVLFF---LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 249 GLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATR-GWMAFPIMILLASGGIGMPALQAMLSRQ 327
Cdd:cd17330 213 GLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 485651500 328 VDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASastWNGLAWIVGAALYLV 380
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL---GPGVPFLLAAGLLLI 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-389 |
1.57e-43 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 155.43 E-value: 1.57e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 10 ILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAI 89
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQI---GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 90 MATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAA 167
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLaDALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 168 VLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIvAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATM 247
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL-LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 248 IGLSLAVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSR 326
Cdd:cd17325 237 IGLLFGAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485651500 327 QVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWnglAWIVGAALYLVCLPALRRGA 389
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT---PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
7-382 |
1.21e-38 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 142.36 E-value: 1.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRdivHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATID 86
Cdd:cd17331 2 LLIVHLNIVLYATCYWLQQPVLPYLTK---KLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 87 YAIMATTPVLWILYAGRIVAgITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLA 165
Cdd:cd17331 79 YLLLAFASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLtKKFGEQAAALV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 166 AAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTI-----VAALMTVFFIMQLVGQVPAALWVIFGEDR 240
Cdd:cd17331 158 AAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLlrlpgVAFLLLVKLLSGLPIGMFQSMFSLVAMDF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 241 FRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGG-IGMPA 319
Cdd:cd17331 238 FGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGsVLYTV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485651500 320 LQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCL 382
Cdd:cd17331 318 ITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYL 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-348 |
7.25e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.94 E-value: 7.25e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 6 ALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA---GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPF 163
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 164 LAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQlvgqvpaALWVIFGEDRFRW 243
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALF-------TYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 244 SATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQA 322
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQA 319
|
330 340
....*....|....*....|....*.
gi 485651500 323 MLSRQVDDDHQGQLQGSLAALTSLTS 348
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
16-380 |
1.86e-33 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 127.73 E-value: 1.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 16 LDAVGIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPV 95
Cdd:cd17390 7 LDLFGVSMILPLLSTHIRSLGASPTVI---GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 96 LWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAIS---LHAPFLAAAVLNGL 172
Cdd:cd17390 84 LALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggfYYVALLCSAIFILN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 173 NLLLGCFLmqeshkgerrpmplrafnpvssfrwargmTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSL 252
Cdd:cd17390 164 AGLVWFLL-----------------------------SKLWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLI 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 253 AVFGILHALAQAFVTGPATKRFGEKQAIIAGMA-ADALGYVLLAFATRGWMAFPIMILLA-SGGIGMPALQAMLSRQVDD 330
Cdd:cd17390 215 SYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFiLLALSLLGLALAPSIWLLVLCLTPLSiSSAVLRTCSTSLLLSRGKS 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 485651500 331 DHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTwnglAWIVGAALYLV 380
Cdd:cd17390 295 KERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSG----PGLLGAVLALA 340
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-382 |
1.32e-29 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 117.67 E-value: 1.32e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 8 IVILGTVTLDAV-GIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATID 86
Cdd:cd17474 1 LYAVFFATLLAVlGVSIVDPILPAIAEALGASPAQV---GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 87 YAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLA 165
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 166 AAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVgqvpAALWVIFGEDRFRWSA 245
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAF----LTYLPFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 246 TMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATR-GWMAFPIMILLASGGIGMPALQAML 324
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSlALLLIAIVLFGLGLGLNLPLLTTLV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 485651500 325 SRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWnglAWIVGAALYLVCL 382
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA---PFLVGAAIALAAA 368
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
58-382 |
2.28e-27 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 111.22 E-value: 2.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 58 LCAPVLGALSDRFGRRPVLLASLLGATIDY------AIMATTPVLWILYAGRIVAGITGATGAVAG---AYIADITDGED 128
Cdd:cd17386 45 FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSlilvliVYFTTVPSVWWFYLSAIPLALFGGFTAFLSasfAYISDISSEKK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 129 RARHFGLMSACFGVGMVAGPVAGG-LLGAISLHAPFLAAAVLNGLNLLLGCFLmqeshkgerrpmplrafnpvssfrwar 207
Cdd:cd17386 125 RTYRMAILEVALGLGGFLGSLLSGhLFKALGYAWSFSISAALLLIALLYILFF--------------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 208 gMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQA--IIAGMA 285
Cdd:cd17386 178 -LTLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLLKMSDStlAMLGLA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 286 ADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASAST 365
Cdd:cd17386 257 SHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKATLTT 336
|
330
....*....|....*..
gi 485651500 366 WNGLAWIVGAALYLVCL 382
Cdd:cd17386 337 FPGFFFLLSAGLLLIPV 353
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
46-352 |
6.18e-26 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 107.89 E-value: 6.18e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPvlWILYAGRIVAGITGATGAVAGAYIADITD 125
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAMISVSGIFSVTFSVIFAYVADITT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 126 GEDRARHFGLMSACFGVGMVAGPVAGGLLGAIslHAPFLAAAVLNGLNLLLGCFLM---QESHKGERRPMPLRAFN---- 198
Cdd:cd17387 117 EEERSTAYGLVSATFAASLVTSPALGAYLSES--YGDNLVVLVATIVALLDICFILlavPESLPEKMRPASWGAPIsweq 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 199 --PVSSFRWARGMTIVAALMTVFFIMQL--VGQ---VPAALWVIFGedrfrWSATMIGLSLAVFGILHALAQAFVTGPAT 271
Cdd:cd17387 195 adPFASLRKVGKDKTVLLICITVFLSYLpeAGQyssFFVYLKQVMG-----FEYEEVAAFIAVVGILSITAQTLLLSILM 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 272 KRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIG 351
Cdd:cd17387 270 RSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLG 349
|
.
gi 485651500 352 P 352
Cdd:cd17387 350 P 350
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
7-382 |
6.59e-26 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 107.27 E-value: 6.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAShyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGatid 86
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLV--PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLL---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 87 YAIMATTPV----LWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHA 161
Cdd:cd17473 75 YGIGGVAGLfldsLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 162 PFLAAAVLNGLNLLLGCFLmqESHKGERRPMPLRAFNPVSSFRWARGMTIVAA---LMTVFFIMQLvgQVPAALwvifgE 238
Cdd:cd17473 155 PFLVYLLALPVLILVLLFL--PEPARKSKSAASPGAATAAALPWKRVLPIYFLaflAMLLFYVIPI--QLPFLL-----Q 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 239 DRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGM 317
Cdd:cd17473 226 ERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485651500 318 PALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTW--NGLAWIVGAALYLVCL 382
Cdd:cd17473 305 PTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSgaFLILGVLALVLAIVLL 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
46-184 |
1.88e-25 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 100.42 E-value: 1.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAG-AYIADIT 124
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485651500 125 DGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFLMQES 184
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAqFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
7-387 |
5.03e-25 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 105.05 E-value: 5.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLL-------RDIVHSDSIASHY--------------------GVLLALYALMQFLC 59
Cdd:cd17389 1 ITIVFLALLLDLLAFTIILPLFPSLLdyygqndDSGLYSLQISSVDwfrdaigapderrynsvlfgGLIGSLFSLLQFLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 60 APVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSAC 139
Cdd:cd17389 81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 140 FGVGMVAGPVAGGLLGAISLH---APFLAAAVLNGLNLLL-----GCFLMQESHKGERRpMPLRAFNPVSSFrwaRGMTi 211
Cdd:cd17389 161 FSLGFIIGPMIGAYFASFTRSlgeVFFSMPALFALVLALAdllfiFFFLPETLPSNLRR-LGLVYFLYLFLF---SGLE- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 212 vaalMTVFFIMQlvgqvpaalwvifgeDRFRWSATMIGLSLAVFGILHALAQafvtGPATKRF---GEKQAIIAGMAADA 288
Cdd:cd17389 236 ----FTLTFLTH---------------QRFQYTSMQQGKMFFFIGIIMALVQ----GGYVRRIkpgKEKKAVLQGLILLI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 289 LGYVLLAFATRGWMAFPIMILLA-SGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTwn 367
Cdd:cd17389 293 PAFLLIGWASSVTVLYAGLFLYSfAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSE-- 370
|
410 420
....*....|....*....|
gi 485651500 368 gLAWIVGAALYLVCLPALRR 387
Cdd:cd17389 371 -ACYTIGALLFLLPLLLLAR 389
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-387 |
2.58e-24 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 103.08 E-value: 2.58e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDIVH-SDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGlSASIV---GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGITGATGAVAG-AYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFL 164
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASeAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 165 AAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARgmTIVAALMTVFFIMQLVGQVPAALwVIFGEDRFRWS 244
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDR--AFLLFLLASFLISLIYFQLESTL-PVYVVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 245 ATMIGLSLAVFGILHALAQAFVTgPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGG-IGMPALQAM 323
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVA-RLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEmLVFPAVQTL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485651500 324 LSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWnglAWIVGAALYLVCLPALRR 387
Cdd:cd17329 314 VAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL---PWLILAALGLIAAALLLG 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-385 |
4.70e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.12 E-value: 4.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 16 LDAVGIGLVMPVLPGLLRDIVHSdsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPV 95
Cdd:cd06174 7 LTGLARGLISPLLPALLQSFGLS---ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 96 LWILYAGRIVAGITGA-TGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI---SLHAPFLAAAVLNG 171
Cdd:cd06174 84 FWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 172 LNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMT-IVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGL 250
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 251 SLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVD 329
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLgFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 485651500 330 DDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASAStwNGLAWIVGAALYLVCLPAL 385
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-354 |
6.14e-22 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 96.12 E-value: 6.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 20 GIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWIL 99
Cdd:cd17489 11 SFYLLLPVLPLYAHDLGGSEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 100 YAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGC 178
Cdd:cd17489 88 LVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 179 FLMQESH--KGERRPMPLRAFnpvSSFRWARGMTIVAALMTVFFIMQLVgqvpAALWVIFGEDRFrwsATMIGLSLAVFG 256
Cdd:cd17489 168 FLVKDPPpvAAEEAEAGTRAF---RRLVEKKVLPPALILFLASIAYGAI----STFLPLYAAERG---ISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 257 ILhALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQ 335
Cdd:cd17489 238 IA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGA 316
|
330
....*....|....*....
gi 485651500 336 LQGSLAALTSLTSIIGPLI 354
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLL 335
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-352 |
1.26e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 1.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 10 ILGTVTLDAVGIGLVMPVLPGLLRDIVHSDsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAI 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGIS--PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 90 MATTPVLWILYAGRIVAGITGATGAVAG-AYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGA-ISLHAPFLAAA 167
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAAlALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 168 VLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAalWVIFGEDRFRWSATM 247
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 248 IGLSLAVFGILhALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFA----TRGWMAFPIMILLASGGIGMPALQAM 323
Cdd:pfam07690 237 AGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltlSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 485651500 324 LSRQVDDDHQGQLQGSLAALTSLTSIIGP 352
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
18-360 |
2.68e-19 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 88.48 E-value: 2.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 18 AVGIGLVMPVLPGLLRDI-VHSDSIASHY-GVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPV 95
Cdd:cd17391 9 GIGFSLIAPFLPLYIEQLgVTSGGLVELWsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 96 LWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNL 174
Cdd:cd17391 89 VWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLaDLFGIRNVFFITGGLLFLAF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 175 LLGCFLMQESHKGERRPMPLRafnPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWS---ATMIGLS 251
Cdd:cd17391 169 LLTLFFVKEDFKPVEKKKMVS---TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDAsnlAFISGLV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 252 LAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGW--MAFPIMILLASGGIgMPALQAMLSRQVD 329
Cdd:cd17391 246 FSATGVSSLLS-APRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqlGILRFLLGLATGGL-LPAINSLLAKITP 323
|
330 340 350
....*....|....*....|....*....|.
gi 485651500 330 DDHQGQLQGSLAALTSLTSIIGPLIVTAIYA 360
Cdd:cd17391 324 KEVAGRIFGYNQSFQYLGNVAGPLLGSAIAA 354
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-387 |
3.24e-19 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 88.44 E-value: 3.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 10 ILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLG-----AT 84
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLV---GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 85 IDYAIMATTPVLWILYAGRIVAGITGATGAVA-GAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAP 162
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPArQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 163 FLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFR 242
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 243 WSATMIGLSLAVFGIlHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQ 321
Cdd:cd06173 241 GGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLgLAGGLFNVPLN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485651500 322 AMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIvtAIYAASASTWNGLAWIVGAALYLVCLPALRR 387
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALL--AGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
42-382 |
1.21e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.86 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATG-AVAGAYI 120
Cdd:COG2223 39 AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 121 ADITDGEDRARHFGLMSACFGVG-MVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNP 199
Cdd:COG2223 119 SKWFPPDRRGLALGLAAGGGNLGaAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 200 VSSFRwargmTIVAALMTVFFIMQLVGQVPAALW-VIFGEDRFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQ 278
Cdd:COG2223 199 LEALR-----DPRFWLLSLLYFGTFGSFIGFSSWlPPYLVDQFGLSAATAGLLAALFALLGALGR-PLGGWLSDRIGGRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 279 AIIAGMAADALGYVLLAFATRGWMAFPIMILL--ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVT 356
Cdd:COG2223 273 VLLIVFALMALGLLLLALALGSLWLFLVLFLLlgLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
|
330 340
....*....|....*....|....*.
gi 485651500 357 AIYAASASTwnGLAWIVGAALYLVCL 382
Cdd:COG2223 353 ALLDATGSY--TAAFLVFAVLALVAL 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
23-377 |
2.12e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 2.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 23 LVMPVLPGLLRDIVHSDSIASHygvLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAG 102
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGL---LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 103 RIVAGIT-GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFL 180
Cdd:cd17324 94 RALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 181 MqESHKGERRPMPLRAFNPVSSFRwaRGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFrwSATMIGLSLAVFGILHA 260
Cdd:cd17324 174 L-PSLPPKKPGSLGLLSSLLLLLR--NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF--SSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 261 LAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSL 340
Cdd:cd17324 249 VG-SPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLY 327
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 485651500 341 AALTSLTSIIGPLI---VTAIYAASASTWNGLAWIVGAAL 377
Cdd:cd17324 328 LAAYNLGGALGAALgglVLDHGGWAGVGWVGAALLLLALL 367
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
7-382 |
3.74e-18 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 84.95 E-value: 3.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSiASHYGVLLALYALMQFLCAPVLGALSDRFG-RRPVLLASLLGATI 85
Cdd:cd17326 1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTAT-ASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 D-----YAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLH 160
Cdd:cd17326 80 GnilyaLAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 161 --------------APFLAAAVLNGLNLLLGCFLMQEshkgerrpmplrafnpvssfrwargmtivAALMTVFFIMQLVG 226
Cdd:cd17326 160 gyvigiklrfnmytAPAWLMAILGIINIILILFFFKE-----------------------------VVCIFLFFVVLFIF 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 227 QVPAALWVIFGEDRFRWSAT----MIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLafatrgwM 302
Cdd:cd17326 211 ANLETIGTPLTMDMYGWTREeavlYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------L 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 303 AFPIMILLASgGIGMP----ALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWnglAWIVGAALY 378
Cdd:cd17326 284 PWGITGVILF-GLGYPignvMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRW---TWIITLGLL 359
|
....
gi 485651500 379 LVCL 382
Cdd:cd17326 360 LLAI 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-168 |
8.50e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.16 E-value: 8.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 1 MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASL 80
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS--PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 81 LGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAIS 158
Cdd:cd17325 273 LLSAVALLLLPLATSFWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLyDAFG 352
|
170
....*....|
gi 485651500 159 LHAPFLAAAV 168
Cdd:cd17325 353 FATPFLAAAA 362
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
7-386 |
3.13e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 82.24 E-value: 3.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDI-VHSDSIASHYGVLLALYALMQFLcapvLGALSDRFGRRPVLLASLLGATI 85
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLgASASAVQLTLSAYLLGFALGQLL----YGPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGITGATGAV-AGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI-SLHAPF 163
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLGAAAGSVvARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFfGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 164 LAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGedRFRW 243
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIE--QLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 244 SATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRG------WMAFPIMILLASGGIGM 317
Cdd:cd17320 235 SPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgglslwPLVAPLFLIFFGFGLIF 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485651500 318 PALQAMLSrqvddDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALR 386
Cdd:cd17320 314 PNATSLAL-----EPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
52-365 |
1.54e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 80.29 E-value: 1.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 52 YALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGA-TGAVAGAYIADITDGEDRA 130
Cdd:cd17321 40 YLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAaIMPASLALIAATFPGERRG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 131 RHFGLMSACFGVGMVAGPVAGGLLGAIS-------LHAPFLAAAVLNGLNLLLGCFLMqeshkgerrpmplrafnpvssf 203
Cdd:cd17321 120 RALGLWGAVVGIGAALGPLLGGLLLELFgwrwiflINVPIGLVALLLARTFSGAVLAA---------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 204 rwargMTIVAALMTVFFIMQLVGQvpaalwvifgeDRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAG 283
Cdd:cd17321 178 -----FLLGAALGGLLFLLPLYLQ-----------GVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 284 MAADALGYVLLAFATRGWMAFPIMILLASGGIGM----PALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIY 359
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLglfaTPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
....*.
gi 485651500 360 AASAST 365
Cdd:cd17321 321 TAGLSA 326
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
42-387 |
6.64e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.79 E-value: 6.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDRFG-----RRPVLLASLLGATIDYAIMATTP------VLWILYAGRIVAGITG 110
Cdd:COG2211 45 AALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPdlsptgKLIYALVTYLLLGLAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 111 ATGAVA-GAYIADIT-DGEDRARHFGLMSACFGVGMVAGPVAGGLL-------GAISLHAPFLAAAVLNGLNLLLGCFLM 181
Cdd:COG2211 125 TLVNIPySALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggdAALGYRLTALIFAVLGLLAFLLTFFGT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 182 QESHKGERRPMPLRAFnpVSSFRWARGMTIVAALMTVFFIMQlvgQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHAL 261
Cdd:COG2211 205 KERPVPEEEKVSLKES--LKALLKNRPFLLLLLAYLLFFLAL---ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 262 AqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRG--WMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQ----- 333
Cdd:COG2211 280 G-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWktgrr 358
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485651500 334 --GQLQGSLAALTSLTSIIGPLIVTAIYAA---------SASTWNGLAW---IVGAALYLVCLPALRR 387
Cdd:COG2211 359 reGLYFGIFTFAIKLGQALAGALAGLLLALfgyvagaaqSPSALTGIRLlffLLPAVLLLLAALLLLF 426
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
46-375 |
1.70e-15 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 77.26 E-value: 1.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRR-PVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADIT 124
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 125 DGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSF 203
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKD 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 204 RWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGedrfrwSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAG 283
Cdd:cd17490 194 KKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGA------SSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 284 MAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIyaAS 362
Cdd:cd17490 268 FLLLGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGII--SE 345
|
330
....*....|...
gi 485651500 363 ASTWNGLAWIVGA 375
Cdd:cd17490 346 AFGLQTGFFVIGV 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-388 |
7.12e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.28 E-value: 7.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADIT 124
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLgLGLLDVAANPYVAALG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 125 DgEDRARHFGLMSACFGVGMVAGPVAGGLL----GAISLHAPFLAAAVLNGLNLLLgcFLMQESHKGERRPMPLRAFNPV 200
Cdd:COG0738 126 P-ETAASRLNLLHAFFSLGALLGPLLGGLLillgLSLSWHLPYLILAVLLLLLALL--FLRSKLPEIEEEEEEAAGSAAS 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 201 SSFRWARGMTIVAALMTVFFIMqlvGQVPAALWVI-FGEDRFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQA 279
Cdd:COG0738 203 LKSLLKNPRLLLGGLAIFLYVG---AEGAIGDWLPlYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 280 IIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHqgqlqGSLAALTSLTSIIGPLIVTAI 358
Cdd:COG0738 279 LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlSLMFPTIFSLALDGLGKRT-----AAAVSAVLIMGIVGGAIGPPL 353
|
330 340 350
....*....|....*....|....*....|.
gi 485651500 359 YAASASTWN-GLAWIVGAALYLVCLPALRRG 388
Cdd:COG0738 354 IGFLADAFGlRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
46-380 |
3.26e-14 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 73.69 E-value: 3.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMqflcapVLGALSDRFGRRPVLLASLLGATIDYAIMATT-----PVLWILyAGRIVAGITGATGAV-AG-- 117
Cdd:cd17449 74 GFLVGLFSVT------LLGPWSDSVGRRPVLILPSLGLALQAAVYLLVmylqlHVAYFL-IGRILSGLLGDFNGIlAGcf 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 118 AYIADITDGEDRARHFGLMSACFGV-GMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHK--GERRPMPL 194
Cdd:cd17449 147 AYVADVSDRRSRTFRVAVLEACLGLaGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKepKSARLFTT 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 195 RAFNPVSSFRWARG----MTIVAALMTVFFIMQLVGQVPAALWVIFG-EDRFRWSATMIGLSLAVfgiLHALAQAFVTGP 269
Cdd:cd17449 227 RHHQSVVRLYVAPApngsRRKLALYSLALFVVVTVHFGAKDLLVLYElSSPLCWDSDLIGYGSAA---EHLTYLSSLLGL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 270 ATKRFGEKQAIIA--GMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLT 347
Cdd:cd17449 304 RLLQLCLEDTWVAeiGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLC 383
|
330 340 350
....*....|....*....|....*....|...
gi 485651500 348 SIIGPLIVTAIYAASASTWNGLAWIVGAALYLV 380
Cdd:cd17449 384 SLVATGIFNSLYPATLHFMKGFPFLFGAALLLI 416
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-380 |
3.59e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.98 E-value: 3.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 10 ILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAI 89
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALI---GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 90 MATTPVLWILYAGRIVAGITGATGAVAG-AYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGaISLHAPFLAAAV 168
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 169 LNGLNLLLGCFLmqeshkgerrPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEdRFRWSATMI 248
Cdd:cd17477 157 LLLLALVPLLLT----------RRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 249 GLSLAVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIG--MPALQAMLSR 326
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGplYTLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 485651500 327 QVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLV 380
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
42-387 |
7.61e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.21 E-value: 7.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYI 120
Cdd:COG2271 44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 121 ADITDGEDRARHFGLMSACFGVG-MVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGcflmqeshkgerrpmplrafnp 199
Cdd:COG2271 124 AEWFPPKERGRALGIFNAGGPLGgALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLR---------------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 200 vssfrwargmtiVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGE--K 277
Cdd:COG2271 182 ------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGRrrK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 278 QAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIG-MPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVT 356
Cdd:COG2271 249 LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGaFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVG 328
|
330 340 350
....*....|....*....|....*....|.
gi 485651500 357 AIYAASASTWNGLAWIVGAALYLVCLPALRR 387
Cdd:COG2271 329 YLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
20-351 |
1.10e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 71.86 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 20 GIGLVMPVLPGLLRDIVHSDSIAShyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWIL 99
Cdd:cd17472 11 GMFLVLPVLSVYAKSLPGATPTLI--GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 100 YAGRIVAGItGATGAVAGAYIADITDGEDRARHFGLMSACFG----VGMVAGPVAGGLLGAISLhapFLAAAVLNGLNLL 175
Cdd:cd17472 89 ILGRALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGiafaISMVLGPLLAAHLGVSGL---FLITAILSLVSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 176 LGCFLMQES--HKGERRPMPLRAFNPVSSFRWAR----GMTIVAALMTVFFIMQL----VGQVPAALWVIFgedrfrWSA 245
Cdd:cd17472 165 ILLFFVPDPpkIVQISEKEKKKLKKLLKNKRLLRldfsIFILHFVLMAFFYILPLlltqLGGGKGQLWKVY------LPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 246 TMIGLSLAVFGILHalaqafvtgpATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPI-MILLASGGIGM-PALQAM 323
Cdd:cd17472 239 ILIGFILMVPFVIY----------AEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIgLIIFFIGFNLLeALLPSL 308
|
330 340
....*....|....*....|....*...
gi 485651500 324 LSRQVDDDHQGQLQGSLAALTSLTSIIG 351
Cdd:cd17472 309 VSKIAPKEYRGTAMGIYNTSQFLGSFLG 336
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
23-363 |
2.24e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 70.68 E-value: 2.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 23 LVMPVLPGLLRDIVHSDSIAShygVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAG 102
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVS---WVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 103 RIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFlm 181
Cdd:cd17504 91 RALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIvQHLGWRWIFWTAAPVAVLLAALVPL-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 182 qeshkgerrpMPLRAF-NPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGedrfrwsATMIGLSLAVFGILHA 260
Cdd:cd17504 169 ----------IDLRLLrRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLG-------ITEAGLLLLPGALVML 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 261 LAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGM--PALQAMLSRQVDDDHQGQLQG 338
Cdd:cd17504 232 IA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLafASLPNIVVESVPPDRTGIATG 310
|
330 340
....*....|....*....|....*
gi 485651500 339 SLAALTSLTSIIGPLIVTAIYAASA 363
Cdd:cd17504 311 MNTVLRTIGSAIGPAIAGAILTTYT 335
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-268 |
4.58e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 69.07 E-value: 4.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 6 ALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSdsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGAS---SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGITGATG-AVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPF 163
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 164 LAAAVLNGLNLLLGCFLmqeshkGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRW 243
Cdd:COG0477 172 LINAPLGLLALVLRLRL------PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260
....*....|....*....|....*
gi 485651500 244 SATMIGLSLAVFGILHALAQAFVTG 268
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLL 270
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-384 |
1.60e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 68.36 E-value: 1.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 6 ALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQA---GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIAditdGEDRARHFGLMSACFGVGMVAG-----PVAGGLLGAISLH 160
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI----KRWFPDRVGLMTGLYTAAMGLGaalaaGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 161 APFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMqLVGQVPAALwvifgeDR 240
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYA-VVAWLPPIL------RD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 241 FRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPAL 320
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 321 QAMLSRQVDDDHQ-GQLQGSLAALTSLTSIIGPLIVTAIYAASASTwnGLAWIVGAALYLVCLPA 384
Cdd:COG2807 325 LTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSW--TAALLLLAALAVLMLVA 387
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
47-168 |
6.08e-12 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 66.41 E-value: 6.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 47 VLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITD 125
Cdd:cd17370 238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADLVP 317
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 485651500 126 GEDRARHFGLMSACFGVG-MVAGPVAGGLLGAISLHAPFLAAAV 168
Cdd:cd17370 318 AELRGTAYGLFNTVVGIGwLLASLIAGYLWDLISPSAAFLFSAV 361
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
61-377 |
3.88e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 64.13 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 61 PVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGA-VAGAYIADITDGEDRARHFGLMSAC 139
Cdd:cd17503 49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 140 FGVGMVAGPVAGG-LLGAISLHAPFLAAAVLNGLNLllgcflmqeshkgerrpmplrAFNPVSSFRWARGMTIVAALMTV 218
Cdd:cd17503 129 ILLAPAIGPTLGGwLTDNLSWRWIFYINLPIGILAL---------------------LLAPLLDLRLFKDRNFTLGLLLS 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 219 FFIMQLVGQVPAALwVIFGEDRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFAT 298
Cdd:cd17503 188 FLLGLGLFGAMFLL-PLYLQNVLGYSAFESGLVLAPGGLASAIL-SPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 299 ----RGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHqgqlQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVG 374
Cdd:cd17503 266 pdtsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQ----IGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRL 341
|
...
gi 485651500 375 AAL 377
Cdd:cd17503 342 SEL 344
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
42-373 |
6.54e-11 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 63.63 E-value: 6.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLA--SLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVA--G 117
Cdd:COG2270 51 TALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAffTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLVfyN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 118 AYIADITDGEDRARHFGLMSACFGVG-------MVAGPVAGGLLGAISLHAP----FLAAAVLNGLNLLLGCFLMQESHK 186
Cdd:COG2270 131 AFLPDIATPEEIGRVSGLGWALGYLGgvlllliNLALFLKPEAFGLPDAGEAvrisFLLTALWWLLFALPLFLFLPERPR 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 187 GERRPMPLRAFNPVS----SFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALA 262
Cdd:COG2270 211 PGPAPPRGAVRAGFRelrrTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 263 qAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLasgGIGMPALQA----MLSRQVDDDHQGQLQG 338
Cdd:COG2270 291 -ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLI---GLVMGGIQAlsrsLLARLIPPGREAEFFG 366
|
330 340 350
....*....|....*....|....*....|....*
gi 485651500 339 SLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIV 373
Cdd:COG2270 367 LYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLI 401
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
10-328 |
9.75e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 62.56 E-value: 9.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 10 ILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAshYGVLLALYALMQFLCAPVLGALSDR-FGRRPVLLASLLGATIDYA 88
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQ--IGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 89 IMATTPVLW-ILYAGRIVAGITGATGAVAGAYI---ADITDGEDRARHFGLMSACFGVGMVAGP-VAGGLLGAISLHAPF 163
Cdd:cd17471 79 LFAFLRNYWvLLLVGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPpLAFLLLDVLGFTGLF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 164 LAAAVLNGLNLLLGCFLMqeshkGERRPMPLRAFNPVSSFRWARGMTIVAAL--MTVFFIMQLVGQVPAALWVIFGedrf 241
Cdd:cd17471 159 LLAALLYLVVALLVLFLL-----PSVKPPAQKATPASSLVKAPVNRRLLLLFaaFTLLFAANSMYIIAMPLYVTNE---- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 242 rwsatmIGLSLAVFGILHALAQAF------VTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLA---- 311
Cdd:cd17471 230 ------LGGSESWVGLLFGLAAALeipimlLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAifig 303
|
330
....*....|....*...
gi 485651500 312 -SGGIGMPALQAMLSRQV 328
Cdd:cd17471 304 iTAGLGISYFQDLMPGQP 321
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
16-360 |
5.23e-10 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 60.70 E-value: 5.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 16 LDAVGIGLVMPVLPGLLRD--IVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATT 93
Cdd:PRK09874 25 LTGAAFSLVMPFLPLYVEQlgVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 94 PVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGL 172
Cdd:PRK09874 105 QNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAdSYGLRPVFFITASVLFL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 173 NLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARgmtIVAALMTVFFIMQLVGQVPAALWVIFGED---RFRWSATMIG 249
Cdd:PRK09874 185 CFLVTLFCIRENFQPVSKKEMLHMREVVTSLKNPK---LVLSLFVTTLIIQVATGSIAPILTLYVRElagNVSNIAFISG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 250 LSLAVFGILhALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQV 328
Cdd:PRK09874 262 MIASVPGVA-ALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLgAADGALLPAVQTLLVYNS 340
|
330 340 350
....*....|....*....|....*....|..
gi 485651500 329 DDDHQGQLQGSLAALTSLTSIIGPLIVTAIYA 360
Cdd:PRK09874 341 SNQIAGRIFSYNQSFRDIGNVTGPLMGAAISA 372
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-381 |
1.92e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.82 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 40 SIASHYGVLLALYALMQflcaPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYA--GRIVAGITGATGAVAG 117
Cdd:cd17355 39 VISLAFTVGLLAFGLAQ----PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLlwGLLGGGGAGTLAAVAF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 118 AYIADITDGEDRARHFGLMSACFGVGMVAG-PVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRA 196
Cdd:cd17355 115 ATVAAWWFERRRGLALGILTAGGGLGSLVFlPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 197 FNPVSSFRWARGMTIVA-ALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVtGPATKRFG 275
Cdd:cd17355 195 SPASPGSTLKEALRSASfWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLS-GWLGDRYS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 276 EKQAIIAGMAADALGYVLLAFAT---RGWMAFPIMILLASGGIgMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGP 352
Cdd:cd17355 274 PRRLLAASYALRALGLALLLLLPfppLALLLFAALFGLGWGAT-VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGP 352
|
330 340
....*....|....*....|....*....
gi 485651500 353 LIVTAIYAASASTwnGLAWIVGAALYLVC 381
Cdd:cd17355 353 WLGGLLYDRTGSY--TAAWALAVALGLIA 379
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
52-363 |
2.20e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 58.34 E-value: 2.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 52 YALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGItGATGAVAGAY--IADITDGEDR 129
Cdd:cd17502 39 YLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGI-GGGGLMSLAFiiIADLVPPRER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 130 ARHFGLMSACFGVGMVAGPVAGGLLG-AISLHApflaaavlnglnlllgCFLMQeshkgerRPMPLRAFNPVSSFrwarg 208
Cdd:cd17502 118 GKYQGYIGAVFGIASVAGPLIGGAFTdHLSWRW----------------CFYIN-------LPIGGLALALLRTI----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 209 mtIVAALMTVFFIMQLVGQVpaALWVIFGEDRFRWSATMIGLSLAVFgILHALAQAFVTGPATKRFG-EKQAIIAGMAAD 287
Cdd:cd17502 170 --LLSSIFGFLFGGALFGLI--YYLPLYFQLVLGDSATKSGVRLLPL-IIGLVIGSIISGALISKTGrYKPLIVIGTILM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 288 ALGYVLLAF---ATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASA 363
Cdd:cd17502 245 SVGAGLLTTltlDTSKWLLIGYLILLGLGlGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLVALA 324
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-154 |
2.89e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 2.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 1 MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASL 80
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS--AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 81 LGATIDYAIMATTPV--LWILYAGRIVAGIT-GATGAVAGAYIADITDgEDRARH--------FGLMSACFGVGMVAGPV 149
Cdd:COG2211 302 LLAALGLLLLFFLGPgnLWLLLVLAALAGIGlGAILVLPWAMLADVVD-YDEWKTgrrreglyFGIFTFAIKLGQALAGA 380
|
....*
gi 485651500 150 AGGLL 154
Cdd:COG2211 381 LAGLL 385
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
2-354 |
3.05e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 58.16 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 2 KSNNALIVILGTVT-LDAVGIGLVMPVLPGLLRDIVHSDSIASHygvLLALYALMQFLCAPVLGALSDRFGRRPVLLASL 80
Cdd:TIGR00710 1 KSAKAFALLLGCLSiLGPLGIDMYLPAFPEIAADLSTPASIVQM---TLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 81 LGATIDYAIMATTPVLWILYAGRIVAGITGATGAV-AGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGG-LLGAIS 158
Cdd:TIGR00710 78 FIFALSSLGLALSNNIETLLVLRFVQAFGASAGSViSQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGyILVWLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 159 LHAPFLAAAVLNGLNLLLGCFLMQESHKGERRpmplrafnpVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGE 238
Cdd:TIGR00710 158 WHAIFAFLSLAGILLSALIFFILPETLPYEAR---------IQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 239 DRFRWSATMiGLSLAVFGILHAL------AQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMIL--L 310
Cdd:TIGR00710 229 APFVYIDIM-GVSPSVFGLLFALniiamiFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIgpM 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 485651500 311 ASGGIGMPALQAMLSRQVDDDhQGQLQGSLAALTS-----LTSIIGPLI 354
Cdd:TIGR00710 308 MFVGIGNSMISSIAMAYALED-FPHVAGTASALFGtlrlvLGAIVGYLV 355
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
22-310 |
8.96e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.80 E-value: 8.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 22 GLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYA 101
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQA---GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 102 GRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLM 181
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 182 QESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIfgeDRFrWSATMIGLSLAVFGILHAL 261
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV---QRG-YSLVFAGLLLSLFLFAGAI 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 485651500 262 AQaFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATrGWMAFPIMILL 310
Cdd:cd17478 246 GT-LIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTP-GIWSYILLVLA 292
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
8-385 |
1.42e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 8 IVILGTVTLDA-VGIGLVMPVLPGLLRDIVHSdsiASHYGVLLALYALMQFLCAPVLGALSDRFGRR-PVLLASLLGATI 85
Cdd:cd17370 1 VWLLGLVSLFAdISYEMARSILPLFLVVLGAS---AAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGP-VAGGLLGAISLHAP- 162
Cdd:cd17370 78 AKPLLALAGSWQLVLLLRILERLgKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPlLAALLLYLLGGNYRt 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 163 -FLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVffimqlvGQVPAALWVIFGEDRF 241
Cdd:cd17370 158 iFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL-------GNFSFAFLILRAQELG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 242 rWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLasgGIGMPALQ 321
Cdd:cd17370 231 -LSAALIPLLYALFNLVYALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW---GLYMGAQE 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485651500 322 ----AMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWnglAWIVGAALYLVCLPAL 385
Cdd:cd17370 306 sierAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA---AFLFSAVLALIALLLL 370
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
62-156 |
2.22e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 55.66 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 62 VLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATG-AVAGAYIADITDGEDRARHFGLMSACF 140
Cdd:cd17323 53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMGVYSLGP 132
|
90
....*....|....*.
gi 485651500 141 GVGMVAGPVAGGLLGA 156
Cdd:cd17323 133 LLGPALGPIIGGFITQ 148
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
20-381 |
2.68e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 55.28 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 20 GIGLVMPVLPGLLRDIVHSDSIAshyGVLLALYALMQFLCAPVLGALSDRFG-RRPVLLASLLGATIDYAIMATTPVLWI 98
Cdd:cd17335 12 ALGSLLPFLSVYLKQLGLSPTQI---GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 99 LYAGRIVAGITGATGAV------AGAYIADITDGEDRARHFGlmSACFGVGMvagPVAGGLLGAISLHAPFLAAAVLNGL 172
Cdd:cd17335 89 LLLLLVILGAFFSAPVVplvdsiTLQYLGEERERYGKQRLWG--SIGFGIAA---LLVGILIDRSSTYKNYTIAFYVFAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 173 NLLLGCFLMQeshKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSL 252
Cdd:cd17335 164 LMLLALLLAL---KFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKTLIGLLW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 253 AVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLA-SGGIGMPALQAMLSRQVDDD 331
Cdd:cd17335 240 TVGVVSEIPFFFFS-SRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGlTFALVWAAAVSYASAAAPPG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 332 HQGQLQGSLAAL-----TSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVC 381
Cdd:cd17335 319 LRATAQGLLQGLyfglgGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
7-157 |
4.37e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.53 E-value: 4.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATID 86
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLS-LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485651500 87 YAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI 157
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL 151
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
42-168 |
5.12e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.14 E-value: 5.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVA-GAYI 120
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAlQALA 305
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 485651500 121 ADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAV 168
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVaELFGYRAMFLLAAV 354
|
|
| MFS_SLC46A3 |
cd17448 |
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
42-380 |
1.47e-07 |
|
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341006 Cd Length: 396 Bit Score: 53.20 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALM-QFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPV----LWILYAGRIVAGITGATGAVA 116
Cdd:cd17448 67 TSLFNMQMDLSGLIpSLIVTLILVSYSDRHGRKFSIILPSIGALLTSLSYCLVSYfsfpLNLLIASSFISGLFGGFTTFI 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 117 G---AYIADI-TDGEDRARHFGLMSACFGV-GMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMqeshkgerrp 191
Cdd:cd17448 147 GgcfAYVADLcKDHKQKTIRMAVVDMILGVlTGLAGLSSGYFIRALGFNWPFLTIALLHVVNLLYILFFL---------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 192 mplrafnpvssfrwargmtIVAALMTVFFIM-QLVGQVPAALWVIFGEDR-FRWSATMIG----LSLAVFgilhalAQAF 265
Cdd:cd17448 217 -------------------VVLCLLLFAFSTyLLANFGGASIFILYELNApLCWNEVLVGygsaASTAIF------LTSF 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 266 VtGPATKRFGEKQAIIA--GMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAAL 343
Cdd:cd17448 272 V-GVALFSRCLPDIYIVfiGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFL 350
|
330 340 350
....*....|....*....|....*....|....*..
gi 485651500 344 TSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLV 380
Cdd:cd17448 351 ETLSGVLSVTIFNSIYAATVAWFPGFSFLLSAGLCLI 387
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
42-382 |
2.52e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 52.24 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDR----FGRR-PVLLASLLGATIDYAIM--ATTPVLWILYAGRIVAGITGATGA 114
Cdd:cd17313 33 HALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrPFILVGAPLAALGLILIpnAADIGLALGDGPRTWALVLFVLGI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 115 V------------AGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAIS---------LHAPFLAAAVLNGLN 173
Cdd:cd17313 113 VlldfamnvcqgpVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNwfgfalggnLKVPFYIGAIILLVC 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 174 LLLGCFLMQE----SHKGERRPMPLRAFNPVSSFRWARGM--TIVAALMTVFF---------------IMQLVGQVPAAL 232
Cdd:cd17313 193 VLVTLFFVKEpplsPEAGEHSENPSLGEVLKSLLKLLKIMprSLLRLLLVIFFwwiaffpfelfftdyMGEEVYHGTSAA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 233 WVIFGEdrfrwSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAfpiMILLAS 312
Cdd:cd17313 273 SSHYGA-----GVRMGAWGLLIFSLAFLIF-SLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVA---LVLFAL 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485651500 313 GGIGMPALQ----AMLSRQVDDD--HQGQLQGSLAALTSLTSIIGPLIVTAIYAAsasTWNGLAWIVGAALYLVCL 382
Cdd:cd17313 344 GGIGWATINinpyPLVSDYHSESgrGQGTDTGLLNLAISLAQILVSLLAGPIIDV---KGYGTVFPVAAVASFLSL 416
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-146 |
3.74e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 3.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 6 ALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS--ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485651500 86 DYAIMATTPVLWILYAGRIVAGIT-GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVA 146
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-377 |
3.81e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.84 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 49 LALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYagrIVAGITGATGAvAGAYIADITDGed 128
Cdd:cd17353 44 FTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF---LGYGVLGGIGA-GIGYITPVSTA-- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 129 rARHF--------GLMSACFGVG-MVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPM------- 192
Cdd:cd17353 118 -VKWFpdkrglatGIVIAGFGLGsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGvdplann 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 193 ---PLRAFNPVSSFRWARGMtivaALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQaFVTGP 269
Cdd:cd17353 197 aenSPRDYTPREMLRTPTFW----LLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGR-PFWGW 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 270 ATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIG--MPALQAMLSRQVDDDHQGQLQGSLAALTSLT 347
Cdd:cd17353 272 LSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGggFALFPALTADFFGTKNAGTNYGLLYTAKGVG 351
|
330 340 350
....*....|....*....|....*....|
gi 485651500 348 SIIGPLIVTaiYAASASTWNGLAWIVGAAL 377
Cdd:cd17353 352 GLIGPIIAA--YVLYTGGYNAAFIIAAALS 379
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
6-185 |
4.00e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 51.81 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 6 ALIVILGTVTldaVGIGLVM--PVLPGLLRDIVHSDSI----ASHYGVLLALYALmqfLCAPVLGALSDRFGRRPVLLAS 79
Cdd:cd17358 4 TFVANLGSFS---FGIAVGWssPALPSLMSDNSLSLPLtvaqFSWFGSLLTLGAL---IGALLSGKLADRIGRKRTLLIS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 80 LLGATIDYAIMATTPVLWILYAGRIVAGIT-GATGAVAGAYIADITDGEDRarhfGLMSACFGVGMVAGPVAGGLLGA-I 157
Cdd:cd17358 78 AIPCILGWLLIAFAKDVWMLYLGRFLAGFGgGAASVVVPVYIAEIAPKNVR----GALGSLNQLLVNIGILLGYVLGSfL 153
|
170 180
....*....|....*....|....*...
gi 485651500 158 SLHAPFLAAAVLNGLNLLLGCFlMQESH 185
Cdd:cd17358 154 PWRTLALIGAIPPVVFLILLFF-IPESP 180
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
27-196 |
1.53e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.93 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 27 VLPGLLRDIVHSDSIASHYGVLLAL-YALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIV 105
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTvFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 106 AGITGATGA-VAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG--AISLHAPFLAAAVLNGLNLLLGCFLMQ 182
Cdd:cd17328 97 VGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqaTGGWRWAFRVTGVLGVLLAILLLLFVR 176
|
170
....*....|....
gi 485651500 183 ESHKGERRPMPLRA 196
Cdd:cd17328 177 EPPRGAAEGGVMAK 190
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
238-386 |
2.89e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.96 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 238 EDRFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIG 316
Cdd:cd06174 23 LQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGsGLI 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 317 MPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALR 386
Cdd:cd06174 102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLL 171
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
46-186 |
3.17e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.71 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRR--PVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIAD 122
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAE 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 123 ITDGEDRARHFGLMSAC-FGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHK 186
Cdd:COG2271 299 LFPKKARGTASGLVNTFgFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-387 |
3.48e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 215 LMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALGYVLL 294
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 295 AFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIyaASASTWNGLAWIV 373
Cdd:pfam07690 80 LFASSLWLLLVLRVLQgLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--ASLFGWRAAFLIL 157
|
170
....*....|....
gi 485651500 374 GAALYLVCLPALRR 387
Cdd:pfam07690 158 AILSLLAAVLLLLP 171
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
201-385 |
4.03e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 4.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 201 SSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAI 280
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 281 IAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIy 359
Cdd:COG2271 79 AIGLLLWGLATLLFGFATSFWQLLLLRFLLgLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL- 157
|
170 180
....*....|....*....|....*.
gi 485651500 360 aASASTWNGLAWIVGAALYLVCLPAL 385
Cdd:COG2271 158 -LAAFGWRAAFLILGLPGLLLALLRF 182
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
64-195 |
4.87e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 48.37 E-value: 4.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 64 GALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVA-GAYIADITDGEDRARhfgLMSACFGV 142
Cdd:PRK11102 47 GPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVViNALMRDMFPKEEFSR---MMSFVTLV 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 485651500 143 GMVA---GPVAGG-LLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRpMPLR 195
Cdd:PRK11102 124 MTIApllAPIIGGwLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPKERR-QPFH 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
211-387 |
8.86e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 8.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 211 IVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALG 290
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 291 YVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWngl 369
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW--- 165
|
170
....*....|....*...
gi 485651500 370 AWIVGAALYLVCLPALRR 387
Cdd:COG2814 166 VFLVNAVLALLALLLLLR 183
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-382 |
2.01e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 64 GALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITdGEDRARHFGLMSACFGV 142
Cdd:cd17333 52 GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLgAGILDTGANTFVGALF-EESSATRLNVLHGFFGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 143 GMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIM 222
Cdd:cd17333 131 GALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 223 QLVGQVPAALWVI-FGEDRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFA-TRG 300
Cdd:cd17333 211 YVGAETAFSSWVPsYLVEKKHVSDGLAGYLLSGFWVGITIG-RLLGGPISRRIKPHTLLVLSGSGALLGLLILLLApTLV 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 301 WMAFPIMILLASGGIGMPALQAMLSRQVdDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAA-SASTWNGLAWIVGAALYL 379
Cdd:cd17333 290 VGLVATALLGLFMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAvGIQTAMLLITILYAIIFV 368
|
...
gi 485651500 380 VCL 382
Cdd:cd17333 369 LAL 371
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
42-364 |
2.34e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.15 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSD----RFGR-RPVLLASLLGATIDYAIMATTP-------VLWiLYAGRIVAGIT 109
Cdd:pfam13347 32 AAAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRrRPWLLLSAIILAVSFILLFTPPelgraplFIW-LLATYILLRIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 110 GATGAVA-GAYIADIT-DGEDRA-----RHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQ 182
Cdd:pfam13347 111 YTFFEIPyWSLGPELTrDYDERTsltsyRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 183 ESHKGERRPMPLRAFNPVSSFRWARGMTIVA------ALMTVFFIMQLVGQVPAALWVIFGEDRFRwSATMIGLSLAVFG 256
Cdd:pfam13347 191 AGTKERVSMRSKEDTGQKEAGSLLDMLKEVFrnraflILLASFLLAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 257 ILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVL-LAFATRGWMAFPIMILLASGGIGM--PALQAMLSRQVDDD-- 331
Cdd:pfam13347 270 IGALLGIPLW-PPLAKRIGKKNTYILGALITIAGFALaLLLGPNNTLLFLVLYIIIGFGYGSsfFLPWSMLADVVDYGel 348
|
330 340 350
....*....|....*....|....*....|....
gi 485651500 332 -HQGQLQGSLAALTSLTSIIGPLIVTAIYAASAS 364
Cdd:pfam13347 349 rTGKRREGTFFAMWSFISKLATGVGLGVSGLLLS 382
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
57-145 |
3.02e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.78 E-value: 3.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 57 FLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAG-AYIADITDGEDRARHFGL 135
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAvVLNTEFLPKKQRAIVGTL 220
|
90
....*....|
gi 485651500 136 MSACFGVGMV 145
Cdd:TIGR00898 221 IQVFFSLGLV 230
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
39-158 |
3.03e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.73 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 39 DSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPV---LWILYAGRIVAGI-TGATGA 114
Cdd:pfam00083 42 AALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIgVGGASV 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 485651500 115 VAGAYIADITDgedrARHFGLMSACFGVGMvagpVAGGLLGAIS 158
Cdd:pfam00083 122 LAPMYISEIAP----KKLRGALGSLYQLAI----TFGILLAYIF 157
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
2-168 |
4.42e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 2 KSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIAShyGVLLALYALMQFLCAPVLGALSD-RFGRRPVLLASL 80
Cdd:cd17474 195 LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII--GLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 81 LGATIDYAIMATTPVLWILYAGRIVAGIT-GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI-S 158
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGlGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIfG 352
|
170
....*....|
gi 485651500 159 LHAPFLAAAV 168
Cdd:cd17474 353 LSAPFLVGAA 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
239-382 |
6.67e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 239 DRFRWSATMIGLSLAVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGM 317
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPL-GFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLgIGGGGSF 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 318 PALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCL 382
Cdd:COG2223 112 AVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
22-131 |
7.23e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 44.57 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 22 GLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYA 101
Cdd:cd17360 14 GVISGALLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIV 93
|
90 100 110
....*....|....*....|....*....|.
gi 485651500 102 GRIVAGI-TGATGAVAGAYIADITDGEDRAR 131
Cdd:cd17360 94 GRVLVGLgVGIASMTVPLYIAEAAPPRIRGR 124
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
64-185 |
1.01e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.10 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 64 GALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSACFGV 142
Cdd:cd17315 55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLgVGLASVLVPLYISEIAPAKIRGALGTLNQLMITF 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 485651500 143 GMVAGPVAGGLLGAISLH--APFLAAAVLNGLNLLLGCFLMQESH 185
Cdd:cd17315 135 GILLAYLLGLALSLSPPGwwRLMFALAAVPALLQLLLMFFLPESR 179
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
20-359 |
1.20e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 43.77 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 20 GIGLVMPVLPGLLRDIVHSdsiASHYGVLLALYALMQFLCAPVLGALSDRFGRR-PVLLASLLGATIDYAIMATTP---V 95
Cdd:pfam12832 14 ALGCLLPYWGLYLRSIGLN---PSEIGLITAILPLTRILAPPIWGWLADRTGKRkAVVRLASILAAVLFLSVLFIPislT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 96 LWILYAGRIVAGITGAtGAVAGAYIADITDGEDRARHFGLMSACFGVGMVagpVAGGLLGAISLHAPFLAAAVLNGLNLL 175
Cdd:pfam12832 91 FWWLALLVVLFSFFWN-AILPQFEVATLQHLGEKRKDYGRQRLWGSVGFA---LSVFGLGALFDHYSVGLLPSVLFYLFA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 176 LGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSLAVf 255
Cdd:pfam12832 167 ALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLGALWAL- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 256 GILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLA-FATRGWMAFPIMILLA-SGGIGMPALQAMLSRQVDDDHQ 333
Cdd:pfam12832 245 GVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAfFVENPWLVLPIQFLHAiSFGLTHAAAIEYVRRIFPGSLQ 324
|
330 340
....*....|....*....|....*..
gi 485651500 334 GQLQGSLAALT-SLTSIIGPLIVTAIY 359
Cdd:pfam12832 325 GTGQALYSGLYfGLGGALGSLIGGQLW 351
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
45-354 |
1.64e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 43.36 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 45 YGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLL---GATIDYAIMA----TTPVLWILYAGRIVAGITGATGAVAG 117
Cdd:cd17385 36 IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFvsgGCTILFGFLDrvpdGTVFIALCFLVRIVEAVGFAAFITAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 118 AYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFLMqeshkgerrPMPLRA 196
Cdd:cd17385 116 FAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLyQAGGYELPFLVLGCLLLLTVPLNMFIL---------PRYDDD 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 197 FNPVSSFRWaRGMTIVAALMTVFFImqlvgqVPAALWVIFGE-------DRFRWSATMIGLSLAVFGILHALAQAFVTGP 269
Cdd:cd17385 187 PSPKSGSML-KLLKIPSVLLLCLSI------VSGSVSLGFLDptlsphlRQFKLSPGQVGLMFLILAGSYAISAPLWGWL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 270 ATKRFGEKQAIIAGMAADALGYVLLA------FATRGWMAFPIMIL--LASGGIGMPALQAMLS----RQVDDD--HQGQ 335
Cdd:cd17385 260 SDKKKIPKWLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLlgLSLGAALVPTFPELLNcareYGFPDNlsTYGL 339
|
330
....*....|....*....
gi 485651500 336 LQGSLAALTSLTSIIGPLI 354
Cdd:cd17385 340 VSGLFNAAFSLGAFIGPTL 358
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
60-389 |
2.32e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 60 APVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFGLMSA 138
Cdd:cd17365 51 ALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRRSLAVTLMFC 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 139 CFGVGMV-AGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGcflmqeshkgerrpmplrafnpvssfrwARGMTIVAALMT 217
Cdd:cd17365 131 GYPLGAAlGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL----------------------------RGTLLLWVTFFM 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 218 VFFIMQLVGQVPAALWVIFGEDRFrwSATMIGLSLAVFGILHALaqafVTGPATKRFGEKQAIIAGMAADALGYVLLAFA 297
Cdd:cd17365 183 GLLLVYLLNSWLPKLMVEAGYSLS--QALTITLLLNIGGVIGSL----LLGWLADRFGPKRVLALFFALGAVSLALLGVS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 298 TRGWMAFPIMILLAsgGIGMPALQAMLSRQVDDDHQGQLQ----GSLAALTSLTSIIGPLIVTAIYAAS-ASTWNGLAWI 372
Cdd:cd17365 257 PASLVLLYVLVFLA--GACVNGAQVGLYALAARFYPTEVRatgvGWALGVGRLGAILGPLLGGLLLAAGlGPESVFLALA 334
|
330
....*....|....*..
gi 485651500 373 VGAALYLVCLPALRRGA 389
Cdd:cd17365 335 IPAALGALAVLLLRLRR 351
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-145 |
2.52e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.57 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 50 ALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGAT-GAVAGAYIADITDGED 128
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGiFTVGFVLGMEIVGPKY 111
|
90
....*....|....*..
gi 485651500 129 RARHFGLMSACFGVGMV 145
Cdd:cd17317 112 RSFVGILFGLFWALGYM 128
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
7-164 |
3.25e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 42.56 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 7 LIVILGTVTLDAVGIGLVMPVLPGLLRDIVHsdsiashYGVLLALYALMQFLCAPVLGALSDRFGRR-PVLLAS--LLGA 83
Cdd:cd17384 2 LVIVYVALLLDNMLLTVVVPIIPDYLNENVR-------VGLLFASKALVQLITNPIVGPLTNRIGYSlPMFVGFviMFIS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 84 TIDYAIMATtpvLWILYAGRIVAGITGATGAVAG-AYIADI-TDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLH 160
Cdd:cd17384 75 TLLFAFGES---YGVLFLARALQGVGSACSSVAGmGMLASLyPDDKERGKAMGIALGGLALGVLVGPPFGGVMyEFVGKS 151
|
....
gi 485651500 161 APFL 164
Cdd:cd17384 152 APFL 155
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-168 |
5.35e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADItd 125
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQEL-- 310
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 485651500 126 gedRARHFGLMSA-----CFGVGMVAGPVAGGLLGAISLHAPFLAAAV 168
Cdd:cd17478 311 ---LPGNVGLASGlmmglSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
41-147 |
6.42e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.47 E-value: 6.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 41 IASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIM-ATTPVLWILYAGRIVAGI-TGATGAVAGA 118
Cdd:cd17356 43 SSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQvAAIGKWYQLIVGRIIAGLgVGFASVLVPV 122
|
90 100
....*....|....*....|....*....
gi 485651500 119 YIADITDGEDRarhfGLMSACFGVGMVAG 147
Cdd:cd17356 123 YQSEVAPKHIR----GTLVSLYQLAITIG 147
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
43-373 |
9.20e-04 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 41.05 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 43 SHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLAS--LLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVA--GA 118
Cdd:cd17482 39 ALWGYANSIASLVIALLAPILGAIADYSGRKKRFLAFfcLIGVVSTALLFFVTPGQWLLALLLFILANIGFSGANVfyDA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 119 YIADITDGEDR----ARHFGL------MSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLlgcflmqeshkge 188
Cdd:cd17482 119 FLPDVASPERMdrvsSLGYALgyigggLLFAVNLVLILGPDAFGLDTAEAVRLSFLSVALWWALFSI------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 189 rrPMPlrafnpvssfrwargmTIVAALMTVFFIMQLVGQVpAALWVIFGEDRFRWSATMIGLSLAVFGILHALAqAFVTG 268
Cdd:cd17482 186 --PLK----------------QLLLFLIAYFFYIDGVQTI-IRMATIYGAEEGKLGSSALILALLLTQFVAFPG-ALLFG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 269 PATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFpimILLASGGIGMPALQA----MLSRQVDDDHQGQLQGSLAALT 344
Cdd:cd17482 246 WLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFW---ILAALIGLVQGGIQAlsrsLFGRLIPKGKSAEFFGFYNISG 322
|
330 340
....*....|....*....|....*....
gi 485651500 345 SLTSIIGPLIVTAIYAASASTWNGLAWIV 373
Cdd:cd17482 323 KFAAIIGPLLFGLITQLTGSSRYGILSLI 351
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
46-154 |
1.00e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 40.76 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 46 GVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAG-AYIAD-I 123
Cdd:cd17383 33 GVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGlAMIADrF 112
|
90 100 110
....*....|....*....|....*....|.
gi 485651500 124 TDGEDRARHFGLMSACFGVGMVAGPVAGGLL 154
Cdd:cd17383 113 TEEAERSKALGIALAFISFGCLVAPPFGGIL 143
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
64-300 |
1.13e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.75 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 64 GALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAY-IADITDGEDRARHFGLMSACFGV 142
Cdd:cd17371 55 GILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAlMAEYVPARHRGKALGYVQSGWAV 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 143 G-----MVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFL----MQESHKGERRPMPLRAFNPVSSFRWARGMTIVA 213
Cdd:cd17371 135 GwllatLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVkeppQWQAARAARRHFADRPSLRELFSPPLLRTTLLA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 214 ALMTVFfimQLVGQVPAALWV-IFGEDRFRWSATMIGLSLAVFgILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYV 292
Cdd:cd17371 215 SLLATG---ALGGYYGITTWLpSYLTGERGLSFEGSAGYLVVT-ILGGFLGYLAGGFLADRIGRRNNFALFALGSAISIL 290
|
....*...
gi 485651500 293 LLAFATRG 300
Cdd:cd17371 291 LYFFLPLS 298
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
52-204 |
1.40e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 40.66 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 52 YALMQFlcapVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRA 130
Cdd:PRK11652 56 YGLSQL----FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLgTGVGGVMARTLPRDLYEGTQLR 131
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 131 RHFGLMSACFGVGMVAGPVAGGLLGAI-SLHAPFLAAAVLNGLNLLLGCFLMQEShkgerRPMPLRAFNPVSSFR 204
Cdd:PRK11652 132 HANSLLNMGILVSPLLAPLIGGLLTTLfGWRACYLFLLLLGAGVTFSMARWMPET-----RPADARRTRVLASYR 201
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
26-184 |
1.50e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.33 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 26 PVLPGLLRDIVHS-DSIASHYGVLLALYALMQFlcapVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRI 104
Cdd:cd17312 24 VAKPPIVEEIGLSkDDLGIIGSAFLIAYAVGKF----ISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 105 VAGITGATG-AVAGAYIADITDGEDRARHFGLMSACFGVG-MVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQ 182
Cdd:cd17312 100 LNGLFQSMGwPPCVKLLGNWFSKKERGTVYGIWSTSHNFGgILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLR 179
|
..
gi 485651500 183 ES 184
Cdd:cd17312 180 DS 181
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-180 |
1.52e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 48 LLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTP-VLWILYAGRIVAGIT-GATGAVAGAYIADITD 125
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGFCyGGGFALFPALTADFFG 333
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 485651500 126 GEDRARHFGLMSACFGVGMVAGP-VAGGLLGAISLHAPFLAAAVLNGLNLLLGCFL 180
Cdd:cd17353 334 TKNAGTNYGLLYTAKGVGGLIGPiIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
15-387 |
1.52e-03 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 40.35 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 15 TLDAVGIGLVMPVLPGLLRDIVHSdsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMA--- 91
Cdd:PRK10489 27 FISIFGLGLLGVAVPVQIQMMTGS---TLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGLGFIGLAlna 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 92 --TTPVLWILYAGRIVAGITGATGAVA-GAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAIS-LHAPFLAAA 167
Cdd:PRK10489 104 flPEPSLLAIYLLGLWDGFFGSLGVTAlLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGgVAWNYGLAA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 168 VLNGLNLLLGCFLMQESHKGERRPMPLRAFnpVSSFRWARGMTIVAALMTVFFIMQLVGQVpAALWVIFGEDRFRWSATM 247
Cdd:PRK10489 184 AGTFITLLPLLRLPALPPPPQPREHPLRSL--LAGFRFLLASPVVGGIALLGGLLTMASAV-RVLYPALADEVWQMGAAQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 248 IGLSLAVFGiLHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQ-AMLSR 326
Cdd:PRK10489 261 IGLLYAAVP-LGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAISSLLQyTLLQT 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485651500 327 QVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYA----ASASTWNGLAWIVGAALYLVCLPALRR 387
Cdd:PRK10489 340 QTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAmmtpVASASASGFGLLIIGVLLLLVLGELRR 404
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
6-99 |
4.63e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 6 ALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMqfLCAPVLGALSDRFGRRPVLLASLLGATI 85
Cdd:cd17367 224 ELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFM--LLQPLGGRLSDRIGRRPLLLFFGIGGTL 301
|
90
....*....|....
gi 485651500 86 dyaimATTPVLWIL 99
Cdd:cd17367 302 -----ATVPLLSAL 310
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
48-121 |
5.02e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 5.02e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485651500 48 LLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATID----YAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIA 121
Cdd:cd17369 269 AVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFafpfFWLLDTGSTWLIVLAAVVVLGVlHGMMYGPQAAFLA 347
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
28-124 |
5.32e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.88 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 28 LPGLLRDIVHSDSiashYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLAS----LLGATIDYAIMATTPVLWILYAGR 103
Cdd:pfam06609 67 LPNILQDIGQSEN----QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAThiigLVGAIVGCTANKFNTLLAAMTLLG 142
|
90 100
....*....|....*....|.
gi 485651500 104 IVAGITGATGAVAGAYIADIT 124
Cdd:pfam06609 143 VAAGPAGASPLFIGELMSNKT 163
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
64-313 |
5.53e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.46 E-value: 5.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 64 GALSDRFGRRPV--------LLASLLGAtidyaiMATTPVLWilYAGRIVAGI-TGATGAVAGAYIADITDGEDRARHFG 134
Cdd:PRK10473 59 GKIADRSGRKPVaipgaalfIIASLLCS------LAETSSLF--LAGRFLQGIgAGCCYVVAFAILRDTLDDRRRAKVLS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 135 LMSACFGVGMVAGPVAGGLlgaISLHAP----FLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMT 210
Cdd:PRK10473 131 LLNGITCIIPVLAPVLGHL---IMLKFPwqslFYTMAAMGILVLLLSLFILKETRPARAPAASSKPRENSESLLNRFFLS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 211 ---IVAALMTVffIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAvfgilhALAQAFVTGPATKRFGEKQAIIAGMAAD 287
Cdd:PRK10473 208 rlvITTLSVTV--ILTFVNTSPVLLMEQMGFSRGEYAIIMALTAGV------SMTVSFSTPFALGIFKPRTLMLTSQVLF 279
|
250 260
....*....|....*....|....*.
gi 485651500 288 ALGYVLLAFATRGWMAFPIMILLASG 313
Cdd:PRK10473 280 LAAGITLALSPSHAVSLFGITLICAG 305
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
52-154 |
5.60e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 5.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 52 YALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRAR 131
Cdd:cd06179 41 WSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGL 120
|
90 100
....*....|....*....|...
gi 485651500 132 HFGLMSACFGVGMVAGPVAGGLL 154
Cdd:cd06179 121 VQGVVNLVASPGSALGPLIAGAL 143
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
18-351 |
6.15e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 18 AVGIGLVMPVLPGLLRDIVHS-DSIASHYgvLLALYALMQFLCAPVLgalsDRFG------RRPVLLASLLGATIDYAIM 90
Cdd:cd17485 10 GLPYGFQSQALPVLLRSAGVSlTAIGLLK--LLYLPWVLKFLWAPLV----DRYGlprlgrRRSWLLPTQLGLALLLLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 91 ATTPV---LWILYAGRIVAGITGATGAVA-GAYIADITDGEDRarhfGLMSACFGVGMVAGPVAGG-----LLGAISLHA 161
Cdd:cd17485 84 AFLPPttnLLAFLGLLFLLNLFSATQDIAtDGLAVELLTPEER----GLGNAAQVVGYKLGSLLGGggllwLYDLIGWQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 162 PFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFfIMQLVGQVPAALWVIFGEDRf 241
Cdd:cd17485 160 LLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLL-LYKLGEQGALAMLPPFLVDR- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 242 RWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQA-IIAGMAADALGYVLLAFATRGWMAFP------IMILLASGG 314
Cdd:cd17485 238 GFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLlLLGGLLRLLLLGLYTLLALGGSGLNWvlllasLALLHLVGG 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 485651500 315 IGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIG 351
Cdd:cd17485 318 MITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLF 354
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
64-131 |
6.78e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 6.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485651500 64 GALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGI-TGATGAVAGAYIADITDGEDRAR 131
Cdd:cd17359 57 GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLaVGGASALVPMYIAEVAPAEIRGR 125
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
60-150 |
7.13e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 38.04 E-value: 7.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 60 APVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAV-AGAYIADITDGEDRARHFGLMSA 138
Cdd:cd17374 52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISInTLILGTEWTTPRHRALAITLTSC 131
|
90
....*....|...
gi 485651500 139 CFGVG-MVAGPVA 150
Cdd:cd17374 132 FFSIGqMLLAGLA 144
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
42-168 |
7.31e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 42 ASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGIT-GATGAVAGAYI 120
Cdd:cd17471 234 ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFiGITAGLGISYF 313
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 485651500 121 ADITDGedrarHFGLMSACFGVGMVAGPVAGGLLGAI-----SLHAPFLAAAV 168
Cdd:cd17471 314 QDLMPG-----QPGLATTLYSNASRIGSLLGGLLAGViaqyfGYRAVFLVCAV 361
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
11-98 |
9.79e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 37.94 E-value: 9.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485651500 11 LGTVTLDAVGIGL--VMPVLPGLLRDIVHSDsiASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYA 88
Cdd:cd17503 182 LGLLLSFLLGLGLfgAMFLLPLYLQNVLGYS--AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90
....*....|....
gi 485651500 89 IMA----TTPVLWI 98
Cdd:cd17503 260 LLAfltpDTSLWLI 273
|
|
| |
