|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
1-489 |
0e+00 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 746.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 1 MNASALFKKIRVKNVIGTLDIQ-----------VDDITTDSRTAKEGSLFVASKGYTvdSHKFCQNVVDQGCGIVVVNRE 69
Cdd:PRK14022 1 ITIETLLDILKKDHNFREIIDQdhyhynysgvqFDDISYDSRTADEGTLFFAKGAYF--KHKFLQNAITQGLKLYVSEKD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 70 LELkgNVTQVVVPDTLRVASLLAHELYEFPSHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKTKG 149
Cdd:PRK14022 79 YEV--GIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 150 ANTTPETVALTKKIKEAVDANAEAMTMEVSSHGLALGRLRGVEFDVAIFSNLTQDHLDF--HGTMEAYGHAKSLLfsqlg 227
Cdd:PRK14022 157 ALTTPESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHKRLL----- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 228 edLSKEKYVVLNND-DDFSDYLASVTPYEVFTYGITHEAQFMAKNikeslqgvEFEFCT---PFGSFPVKspYVGRFNIS 303
Cdd:PRK14022 232 --MENSKAVVVNSDmDHFSELLEQVTPQEHDFYGIDSENQIMASN--------AFSFEAtgkLAGTYDIQ--LIGKFNQE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 304 NIMAAMIAVWSKGTNLNEIINAVTElEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGER 383
Cdd:PRK14022 300 NAMAAGLACLRLGASLEDIQKGIAQ-TPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNK 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 384 DLTKTPEMGRVACRADY--VIFTPDNPANDDPKMLTAELAKGATHnnYIE-FDDRAEGIRHAIDIAE-PGDTVVLASKGR 459
Cdd:PRK14022 379 GESRRPDFGRVANRHPYlqVILTADDPNNEDPKMITQEIASHITH--PVEiIDDRAEAIKHAMSITEgPGDAVIIAGKGA 456
|
490 500 510
....*....|....*....|....*....|
gi 487747182 460 EPYQIMPGhvkvpHRDDLIGLKAAYQKFGG 489
Cdd:PRK14022 457 DAYQIVPG-----HRDDYIGDEAAAKKYLG 481
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
25-475 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 549.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 25 DITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELKG-NVTQVVVPDTLRVASLLAHELYEFPSHQL 103
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAaGVPVIVVPDPRAALALLAAAFYGHPSQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 104 TTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKTKGANTTPETVALTKKIKEAVDANAEAMTMEVSSHGL 183
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 184 ALGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYVVLNNDDDFSDYLASVTPYEVFTYGITH 263
Cdd:COG0769 161 DQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPG----GAAVINADDPYGRRLAAAAPARVITYGLKA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 264 EAQFMAKNIKESLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEVLDPSL 343
Cdd:COG0769 237 DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQ 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 344 PIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNPANDDPKMLTAELAK 422
Cdd:COG0769 317 GPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARlADVVIVTSDNPRSEDPAAIIADILA 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 487747182 423 GATH-NNYIEFDDRAEGIRHAIDIAEPGDTVVLASKGREPYQIMpGHVKVPHRD 475
Cdd:COG0769 397 GIPGaGKVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQII-GGVKIPFDD 449
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
20-475 |
1.13e-144 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 422.88 E-value: 1.13e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 20 DIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELK-GNVTQVVVPDTLRVASLLAHELYEF 98
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYvAPVPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 99 PSHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQV---NETKTKGANTTPETVALTKKIKEAVDANAEAMT 175
Cdd:TIGR01085 81 PSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLggnDLIKNPAALTTPEALTLQSTLAEMVEAGAQYAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 176 MEVSSHGLALGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKekyvVLNNDDDFSDYLASVTPYE 255
Cdd:TIGR01085 161 MEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFA----VINLDDEYGAQFVKRLPKD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 256 VFTYGITHEAQFMAKNIKE-----SLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWS-KGTNLNEIINAVTEL 329
Cdd:TIGR01085 237 ITVSAITQPADGRAQDIKItdsgySFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHlGGIDLEDIVAALEKF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 330 EPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNP 408
Cdd:TIGR01085 317 RGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQlADLVILTSDNP 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487747182 409 ANDDPKMLTAELAKGATH-NNYIEFDDRAEGIRHAIDIAEPGDTVVLASKGREPYQIMpGHVKVPHRD 475
Cdd:TIGR01085 397 RGEDPEQIIADILAGISEkEKVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQII-GGETIPFDD 463
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
108-312 |
1.82e-66 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 212.55 E-value: 1.82e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 108 VTGTNGKTSIATMIHLIYRKLnknSAYLGTNGFQVNETKtkgaNTTPETVALTKKIKEAVDANAEAMTMEVSSHGLALGR 187
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLA---GGVIGTIGTYIGKSG----NTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 188 LRG-VEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLskekYVVLNNDDDFSDYL---ASVTPYEVFTYGITH 263
Cdd:pfam08245 74 LSGlLKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDG----IAVINADDPYGAFLiakLKKAGVRVITYGIEG 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 487747182 264 EAQFMAKNIKESLQGVEFEFC-TPFGSFPVKSPYVGRFNISNIMAAMIAV 312
Cdd:pfam08245 150 EADLRAANIELSSDGTSFDLFtVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
108-457 |
1.44e-03 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 41.16 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 108 VTGTNGKTSIATMIHLIYRklNKNSAYLGTNGFQVNETK--TKGANTTPETV-ALTKKIKEAVDANAEAMTMEVSshgla 184
Cdd:NF033197 97 ITGVKGKTTTAELLAHILS--DEYVLLHTSRGTERYPEGelSNKGSITPASIlNALELAEEIGIDDYGFLIFEVS----- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 185 LGRLrgVEFDVAIFSNLTQDHLDFHGTMEAYgHAKSLLFSqlgedLSKEKYVVLNNDDdfsDYLASVTPYEVFTYGithe 264
Cdd:NF033197 170 LGGT--GAGDVGIITNILEDYPIAGGKRSAS-AAKLQSLK-----NAKVGSINVADLG---IYINGKNKLVITVAG---- 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 265 aqfmaKNIKeSLQGVEFEFCTpfGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEV--LDPS 342
Cdd:NF033197 235 -----VEIL-SKYPLRFKYGN--TEFEFNPLLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPGRMAVkkEGGV 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 343 LPIDLI--------IDYAhTADGMNKLIDAVqpfvkqklIFLVGMAG-------ERDLTKTPEMGRVACRaDYVIFTPDn 407
Cdd:NF033197 307 VIVDNInpglnvkaIEYA-LDDALELLGDGT--------LVIGGDFGvvceeidIDKLSEVLKKYRPKID-ILVGVGTE- 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 487747182 408 panddpkmLTAELAKGATHNNYIEFDDRAEGIRHAIDIAEPGDTVVLASK 457
Cdd:NF033197 376 --------LGKRLKKYLDKLEGYEAGTLEEGLDDARELTGEGNTLVIYRK 417
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
1-489 |
0e+00 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 746.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 1 MNASALFKKIRVKNVIGTLDIQ-----------VDDITTDSRTAKEGSLFVASKGYTvdSHKFCQNVVDQGCGIVVVNRE 69
Cdd:PRK14022 1 ITIETLLDILKKDHNFREIIDQdhyhynysgvqFDDISYDSRTADEGTLFFAKGAYF--KHKFLQNAITQGLKLYVSEKD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 70 LELkgNVTQVVVPDTLRVASLLAHELYEFPSHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKTKG 149
Cdd:PRK14022 79 YEV--GIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 150 ANTTPETVALTKKIKEAVDANAEAMTMEVSSHGLALGRLRGVEFDVAIFSNLTQDHLDF--HGTMEAYGHAKSLLfsqlg 227
Cdd:PRK14022 157 ALTTPESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHKRLL----- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 228 edLSKEKYVVLNND-DDFSDYLASVTPYEVFTYGITHEAQFMAKNikeslqgvEFEFCT---PFGSFPVKspYVGRFNIS 303
Cdd:PRK14022 232 --MENSKAVVVNSDmDHFSELLEQVTPQEHDFYGIDSENQIMASN--------AFSFEAtgkLAGTYDIQ--LIGKFNQE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 304 NIMAAMIAVWSKGTNLNEIINAVTElEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGER 383
Cdd:PRK14022 300 NAMAAGLACLRLGASLEDIQKGIAQ-TPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNK 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 384 DLTKTPEMGRVACRADY--VIFTPDNPANDDPKMLTAELAKGATHnnYIE-FDDRAEGIRHAIDIAE-PGDTVVLASKGR 459
Cdd:PRK14022 379 GESRRPDFGRVANRHPYlqVILTADDPNNEDPKMITQEIASHITH--PVEiIDDRAEAIKHAMSITEgPGDAVIIAGKGA 456
|
490 500 510
....*....|....*....|....*....|
gi 487747182 460 EPYQIMPGhvkvpHRDDLIGLKAAYQKFGG 489
Cdd:PRK14022 457 DAYQIVPG-----HRDDYIGDEAAAKKYLG 481
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
25-475 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 549.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 25 DITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELKG-NVTQVVVPDTLRVASLLAHELYEFPSHQL 103
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAaGVPVIVVPDPRAALALLAAAFYGHPSQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 104 TTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKTKGANTTPETVALTKKIKEAVDANAEAMTMEVSSHGL 183
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 184 ALGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYVVLNNDDDFSDYLASVTPYEVFTYGITH 263
Cdd:COG0769 161 DQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPG----GAAVINADDPYGRRLAAAAPARVITYGLKA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 264 EAQFMAKNIKESLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEVLDPSL 343
Cdd:COG0769 237 DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQ 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 344 PIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNPANDDPKMLTAELAK 422
Cdd:COG0769 317 GPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARlADVVIVTSDNPRSEDPAAIIADILA 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 487747182 423 GATH-NNYIEFDDRAEGIRHAIDIAEPGDTVVLASKGREPYQIMpGHVKVPHRD 475
Cdd:COG0769 397 GIPGaGKVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQII-GGVKIPFDD 449
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
20-486 |
2.26e-156 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 452.28 E-value: 2.26e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 20 DIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELKGNVTQVVVPDTLRVASLLAHELYEFP 99
Cdd:PRK00139 12 PVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAGTGVPVIIVPDLRKALALLAAAFYGHP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 100 SHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKTKGANTTPETVALTKKIKEAVDANAEAMTMEVS 179
Cdd:PRK00139 92 SDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQRLLAELVDAGVTYAAMEVS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 180 SHGLALGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGedlskeKYVVLNNDDDFSDYLASvtpyEVFTY 259
Cdd:PRK00139 172 SHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELG------LAAVINADDEVGRRLLA----LPDAY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 260 GIT-HEAQFMAKNIKESLQGVEFEFCTPFgsfpvKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEV 338
Cdd:PRK00139 242 AVSmAGADLRATDVEYTDSGQTFTLVTEV-----ESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMER 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 339 LDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNPANDDPKMLT 417
Cdd:PRK00139 317 VDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERlADVVIVTSDNPRSEDPAAII 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487747182 418 AELAKGATHNnyIEfdDRAEGIRHAIDIAEPGDTVVLASKGREPYQIMpGHVKVPHrDDLIGLKAAYQK 486
Cdd:PRK00139 397 ADILAGIYDV--IE--DRAEAIRYAIAQAKPGDVVLIAGKGHEDYQII-GGVKIPF-DDREVAREALAE 459
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
20-475 |
1.13e-144 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 422.88 E-value: 1.13e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 20 DIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELK-GNVTQVVVPDTLRVASLLAHELYEF 98
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYvAPVPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 99 PSHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQV---NETKTKGANTTPETVALTKKIKEAVDANAEAMT 175
Cdd:TIGR01085 81 PSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLggnDLIKNPAALTTPEALTLQSTLAEMVEAGAQYAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 176 MEVSSHGLALGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKekyvVLNNDDDFSDYLASVTPYE 255
Cdd:TIGR01085 161 MEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFA----VINLDDEYGAQFVKRLPKD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 256 VFTYGITHEAQFMAKNIKE-----SLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWS-KGTNLNEIINAVTEL 329
Cdd:TIGR01085 237 ITVSAITQPADGRAQDIKItdsgySFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHlGGIDLEDIVAALEKF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 330 EPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNP 408
Cdd:TIGR01085 317 RGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQlADLVILTSDNP 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487747182 409 ANDDPKMLTAELAKGATH-NNYIEFDDRAEGIRHAIDIAEPGDTVVLASKGREPYQIMpGHVKVPHRD 475
Cdd:TIGR01085 397 RGEDPEQIIADILAGISEkEKVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQII-GGETIPFDD 463
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
23-491 |
1.21e-111 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 352.47 E-value: 1.21e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 23 VDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELE---LKGNVTQVVVPDTLRVASLLAHELYEFP 99
Cdd:PRK11929 29 TADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEdqvAAADALVLPVADLRKALGELAARWYGRP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 100 SHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKTKGANTTPETVALTKKIKEAVDANAEAMTMEVS 179
Cdd:PRK11929 109 SEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGRLIPGSLTTPDAIILHRILARMRAAGADAVAMEAS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 180 SHGLALGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYVVLNNDDDFSDYLASVTPYEV-FT 258
Cdd:PRK11929 189 SHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGL----GAAVINADDPAAARLLAALPRGLkVG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 259 YGITH-EAQFMAKNIKESLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLE 337
Cdd:PRK11929 265 YSPQNaGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRME 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 338 VLDPSLPI---DLIIDYAHTADGMNKLIDAVQP---FVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNPAN 410
Cdd:PRK11929 345 RVGPTAGAqgpLVVVDYAHTPDALAKALTALRPvaqARNGRLVCVFGCGGDRDKGKRPEMGRIAAElADRVVVTSDNPRS 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 411 DDPKMLTAELAKGATH-NNYIEFDDRAEGIRHAIDIAEPGDTVVLASKGREPYQIMPGHvKVPHRDDLIGLKAAYQKFGG 489
Cdd:PRK11929 425 EAPEAIIDQILAGIPAgARVFVISDRAEAIRQAIWMAAPGDVILIAGKGHETYQEIGGR-KLFFDDREWARRALLARISS 503
|
..
gi 487747182 490 GP 491
Cdd:PRK11929 504 TL 505
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
108-312 |
1.82e-66 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 212.55 E-value: 1.82e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 108 VTGTNGKTSIATMIHLIYRKLnknSAYLGTNGFQVNETKtkgaNTTPETVALTKKIKEAVDANAEAMTMEVSSHGLALGR 187
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLA---GGVIGTIGTYIGKSG----NTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 188 LRG-VEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLskekYVVLNNDDDFSDYL---ASVTPYEVFTYGITH 263
Cdd:pfam08245 74 LSGlLKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDG----IAVINADDPYGAFLiakLKKAGVRVITYGIEG 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 487747182 264 EAQFMAKNIKESLQGVEFEFC-TPFGSFPVKSPYVGRFNISNIMAAMIAV 312
Cdd:pfam08245 150 EADLRAANIELSSDGTSFDLFtVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
15-458 |
1.31e-49 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 176.06 E-value: 1.31e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 15 VIGTLDIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELkgNVTQVVVPDTLRVASLLAHE 94
Cdd:COG0770 16 LIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPA--DLPLIVVDDTLKALQQLAAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 95 LYEfpSHQLTTYGVTGTNGKTSIATMIHLIyrklnknsayLGTNGfQVneTKTKGA-NTT---PETVAltkkikeAVDAN 170
Cdd:COG0770 94 HRA--RFNIPVIAITGSNGKTTTKEMLAAV----------LSTKG-KV--LATPGNfNNEigvPLTLL-------RLPED 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 171 AEAMTMEVS-SH-G--LALGRLrgVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFsqlgEDLSKEKYVVLNNDDDFSD 246
Cdd:COG0770 152 HEFAVLEMGmNHpGeiAYLARI--ARPDIAVITNIGPAHLEGFGSLEGIARAKGEIF----EGLPPGGVAVLNADDPLLA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 247 YLASVTPYEVFTYGITHEAQFMAKNIKESLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAV 326
Cdd:COG0770 226 ALAERAKARVLTFGLSEDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 327 TELEPVEGRLEVLDPSLPIDLIIDyAHTA--DGMNKLID--AVQPFVKQKLIFLVGMA--GErdltKTPEM----GRVAC 396
Cdd:COG0770 306 AAFQPVKGRLEVIEGAGGVTLIDD-SYNAnpDSMKAALDvlAQLPGGGRRIAVLGDMLelGE----ESEELhrevGELAA 380
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487747182 397 RA--DYVIFTPDnpanddpkmLTAELAKGATHNNYIEFDDRAEGIRHAIDIAEPGDTVVL-ASKG 458
Cdd:COG0770 381 ELgiDRLFTVGE---------LARAIAEAAGGERAEHFEDKEELLAALKALLRPGDVVLVkGSRG 436
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
28-458 |
2.04e-41 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 153.19 E-value: 2.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 28 TDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELKGNVTQVVVPDTLRVASLLAHELYE-FPShqlTTY 106
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNGLPQILVDDTLEALQALARAKRAkFSG---KVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 107 GVTGTNGKTSIATMIHLIyrkLNKNSAYLGTNGFQVNETktkganTTPETVAltkkikeAVDANAEAMTME--VSSHG-- 182
Cdd:TIGR01143 78 GITGSSGKTTTKEMLAAI---LSHKYKVFATPGNFNNEI------GLPLTLL-------RAPGDHDYAVLEmgASHPGei 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 183 LALGRLrgVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQlgedLSKEKYVVLNNDDDFSDYLASVTPY-EVFTYGI 261
Cdd:TIGR01143 142 AYLAEI--AKPDIAVITNIGPAHLEGFGSLEGIAEAKGEILQG----LKENGIAVINADDPAFADLAKRLPNrNILSFGF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 262 ThEAQFMAKNIKESLQGVE-FEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEVL- 339
Cdd:TIGR01143 216 E-GGDFVAKDISYSALGSTsFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQt 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 340 DPSLpidLIIDYAHTA--DGMNKLIDAVqPFVKQKLIFLVG-MA--GERDLTKTPEMGRVACRA--DYVIFTPdnpanDD 412
Cdd:TIGR01143 295 KNGL---TLIDDTYNAnpDSMRAALDAL-ARFPGKKILVLGdMAelGEYSEELHAEVGRYANSLgiDLVFLVG-----EE 365
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 487747182 413 PKMLTAELAKGATHnnyieFDDRAEGIRHAIDIAEPGDTVVL-ASKG 458
Cdd:TIGR01143 366 AAVIYDSFGKQGKH-----FADKDELLAFLKTLVRKGDVVLVkGSRS 407
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
20-366 |
4.01e-30 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 122.06 E-value: 4.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 20 DIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELkgNVTQVVVPDTlRVAsllAHELYEFP 99
Cdd:PRK10773 21 DITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDI--DLPQLVVKDT-RLA---FGQLAAWV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 100 SHQLTTYGV--TGTNGKTSIATMIHLIYRKLNkNSAYLGTN------------------GFQVNETktkGANTTPE---T 156
Cdd:PRK10773 95 RQQVPARVValTGSSGKTSVKEMTAAILRQCG-NTLYTAGNlnndigvpltllrltpehDYAVIEL---GANHQGEiayT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 157 VALTKkikeavdanAEAmtmevsshglalgrlrgvefdvAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYV 236
Cdd:PRK10773 171 VSLTR---------PEA----------------------ALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPEN----GIA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 237 VLNND-DDFSDYLASVTPYEV--FTYGITHEAQFMAKNIKESLQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVW 313
Cdd:PRK10773 216 IMNADsNDWLNWQSVIGSKTVwrFSPNAANSVDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAM 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 487747182 314 SKGTNLNEIINAVTELEPVEGRLevldpsLPIDL-----IIDYAHTADgMNKLIDAVQ 366
Cdd:PRK10773 296 SVGATLDAVKAGLANLKAVPGRL------FPIQLaegqlLLDDSYNAN-VGSMTAAAQ 346
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
16-382 |
4.76e-29 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 121.35 E-value: 4.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 16 IGTLDIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELKGnVTQVVVPDTLRVASLLAHEL 95
Cdd:PRK11929 519 QINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVD-LPQIVVDDTRAALGRLATAW 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 96 YEfpSHQLTTYGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKtkganttpetVALTKKikeAVDANAEAMT 175
Cdd:PRK11929 598 RA--RFSLPVVAITGSNGKTTTKEMIAAILAAWQGEDRVLATEGNFNNEIG----------VPLTLL---RLRAQHRAAV 662
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 176 MEVSSHGLA-LGRLRG-VEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYVVLNNDDDF-SDYLASVT 252
Cdd:PRK11929 663 FELGMNHPGeIAYLAAiAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPED----GVAVVNGDDPYtAIWAKLAG 738
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 253 PYEVFTYGITH----EAQFMAKNIKESLQG-VEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVT 327
Cdd:PRK11929 739 ARRVLRFGLQPgadvYAEKIAKDISVGEAGgTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLE 818
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 487747182 328 ELEPVEGRLEVLDPSLPIDLIID-YAHTADGMNKLIDAVQPFVKQKLIFLVGMAGE 382
Cdd:PRK11929 819 RFQPVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGDMLE 874
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
107-455 |
9.51e-25 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 106.32 E-value: 9.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 107 GVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGfqvnetktkganttpetVALTKKIKEAVDAnaEAMTMEVSSHGLALg 186
Cdd:COG0771 109 AITGTNGKTTTTTLIGHILKAAGLRVAVGGNIG-----------------TPLLDLLLEPEPP--DVYVLELSSFQLET- 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 187 rLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYVVLNNDDDFSDYLASVTPYEVFTYGITHEAQ 266
Cdd:COG0771 169 -TPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPD----DYAVLNADDPLTRALAEEAKARVVPFSLKEPLE 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 267 FMA----KNIKESLQGVEfefctpfgSFPVKS-PYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEvldp 341
Cdd:COG0771 244 GGAgledGKLVDRASGEE--------LLPVDDlRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLE---- 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 342 slpidliidYAHTADGM---------NklIDAVQP----FvKQKLIFLVGmaGE-RDLTKTPEMGRVACRADYVIFTPDn 407
Cdd:COG0771 312 ---------FVAEINGVrfindskatN--PDATLAalesF-DGPVVLIAG--GLdKGADFSPLAPAVAERVKAVVLIGE- 376
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 487747182 408 panDDPKMltAELAKGAtHNNYIEFDDRAEGIRHAIDIAEPGDTVVLA 455
Cdd:COG0771 377 ---DAEKI--AAALAGA-GVPVVIVETMEEAVAAAAELARPGDVVLLS 418
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
332-414 |
6.41e-23 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 92.41 E-value: 6.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 332 VEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACR-ADYVIFTPDNPAN 410
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAAlADVVILTGDYPRA 80
|
....
gi 487747182 411 DDPK 414
Cdd:pfam02875 81 EDPG 84
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
106-454 |
1.31e-21 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 97.35 E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 106 YGVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNEtktKGANTTPETValtkkikeavdanaeaMTMEVSSHGLAL 185
Cdd:PRK14106 111 VAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLID---AVEEYGEDDI----------------IVAEVSSFQLET 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 186 GRlrgvEF--DVAIFSNLTQDHLDFHGTMEAYGHAKSLLFsqlgEDLSKEKYVVLNNDDDFSDYLASVTPYEVFTYGITH 263
Cdd:PRK14106 172 IK----EFkpKVGCILNITPDHLDRHKTMENYIKAKARIF----ENQRPSDYTVLNYDDPRTRSLAKKAKARVIFFSRKS 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 264 EAQ---FMAKN-IKESLQGVEFEFCtpfgsfPVKSPYV-GRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEV 338
Cdd:PRK14106 244 LLEegvFVKNGkIVISLGGKEEEVI------DIDEIFIpGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEF 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 339 LDPSLPIDLIIDYAHT-ADGMNKLIDAV-QPFVkqkLIflvgmAGERDltKTPEMGRVAcradyviftpdNPANDDPKML 416
Cdd:PRK14106 318 VAEINGVKFINDSKGTnPDAAIKALEAYeTPIV---LI-----AGGYD--KGSDFDEFA-----------KAFKEKVKKL 376
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 487747182 417 ------TAELAKGATHNNYIEF---DDRAEGIRHAIDIAEPGDTVVL 454
Cdd:PRK14106 377 illgetAQEIAEAARKYGFDNIlfaETLEEAVKKAYEIAKPGDVVLL 423
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
107-455 |
1.86e-21 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 96.64 E-value: 1.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 107 GVTGTNGKTSIATMIHLIYRKlnknsaylgtNGFQVNEtktkGANTTpeTVALtkkikEAVD-ANAEAMTMEVSSHGLAl 185
Cdd:TIGR01087 106 AITGTNGKTTTTSLLYHLLKA----------AGLKAFL----GGNIG--TPAL-----EVLDqEGAELYVLELSSFQLE- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 186 gRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDlskeKYVVLNNDDDFSDYLASVTPYEVFTYGITHEA 265
Cdd:TIGR01087 164 -TTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEG----DVAVLNADDPRFARLAQKSKAQVIWFSVEKDA 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 266 QFmaknikeslqgvEFEFCTPFGSFPVKS---PYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEVLDPS 342
Cdd:TIGR01087 239 ER------------GLCIRDGGLYLKPNDlegSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQK 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 343 LPIDLIIDYAHTAdgmnklIDAVQPFVKQ---KLIFLV-GMAGERDLtkTPEMGRVACRADYVIFtpdnpANDDPKMLtA 418
Cdd:TIGR01087 307 NGVHFYNDSKATN------VHATLAALSAfdnPVILIVgGDDKGADF--SPLAPAAAGKVKAVLA-----IGEDAAKI-A 372
|
330 340 350
....*....|....*....|....*....|....*..
gi 487747182 419 ELAKGATHNNYIeFDDRAEGIRHAIDIAEPGDTVVLA 455
Cdd:TIGR01087 373 PLLKEAGLSVYL-VESLEEAVQAAREVASPGDVVLLS 408
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
107-322 |
4.04e-14 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 74.81 E-value: 4.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 107 GVTGTNGKTSIATMIHLIYRKLNKNSAYLGTNGFQVNETKT-KGANTTPET--VALTkkikeavDANAEAMTMEVSSHGL 183
Cdd:PRK14016 484 AVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGVYIDGRLIdKGDCTGPKSarRVLM-------NPDVEAAVLETARGGI 556
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 184 algrLR-GVEFD---VAIFSNLTQDHLDFHG--TMEAYGHAKSLlfsqLGEDLSKEKYVVLNNDDDFSDYLASVTPYEVF 257
Cdd:PRK14016 557 ----LReGLAYDrcdVGVVTNIGEDHLGLGGinTLEDLAKVKRV----VVEAVKPDGYAVLNADDPMVAAMAERCKGKVI 628
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487747182 258 TYGITHEAQFMAKNIKES-------------LQGVEFEFCTPFGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEI 322
Cdd:PRK14016 629 FFSMDPDNPVIAEHRAQGgravyvegdyivlAEGGWEIRIISLADIPLTLGGKAGFNIENALAAIAAAWALGIDIELI 706
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
16-115 |
3.44e-09 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 59.20 E-value: 3.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 16 IGTLDIQVDDITTDSRT--AKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRELELKGNVTQV---VVPDTLRVASL 90
Cdd:PRK11930 17 LGDKDAIIDQILTDSRSlsFPENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHPEESYPDAnflKVKDPLKALQE 96
|
90 100
....*....|....*....|....*
gi 487747182 91 LAHelYEFPSHQLTTYGVTGTNGKT 115
Cdd:PRK11930 97 LAA--YHRSQFDIPVIGITGSNGKT 119
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
26-96 |
8.24e-05 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 41.07 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 26 ITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNRE--------LELKG-NVTQVVVPDTLRVASLLAHELY 96
Cdd:pfam01225 5 VGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAannispdnPELEAaKVPGIPVIDRREALAELAAAFY 84
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
15-116 |
2.65e-04 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 43.22 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 15 VIGTLDIQVDDITTDSRTAKEGSLFVASKGYTVDSHKFCQNVVDQGCGIVVVNREL--ELKGNVTQVVVPDTLRVASLLA 92
Cdd:PRK14093 20 RSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQrdKFAADAPLLVVDDVLAALRDLG 99
|
90 100
....*....|....*....|....
gi 487747182 93 HELYEFPSHQLTtyGVTGTNGKTS 116
Cdd:PRK14093 100 RAARARLEAKVI--AVTGSVGKTS 121
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
108-457 |
1.44e-03 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 41.16 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 108 VTGTNGKTSIATMIHLIYRklNKNSAYLGTNGFQVNETK--TKGANTTPETV-ALTKKIKEAVDANAEAMTMEVSshgla 184
Cdd:NF033197 97 ITGVKGKTTTAELLAHILS--DEYVLLHTSRGTERYPEGelSNKGSITPASIlNALELAEEIGIDDYGFLIFEVS----- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 185 LGRLrgVEFDVAIFSNLTQDHLDFHGTMEAYgHAKSLLFSqlgedLSKEKYVVLNNDDdfsDYLASVTPYEVFTYGithe 264
Cdd:NF033197 170 LGGT--GAGDVGIITNILEDYPIAGGKRSAS-AAKLQSLK-----NAKVGSINVADLG---IYINGKNKLVITVAG---- 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 265 aqfmaKNIKeSLQGVEFEFCTpfGSFPVKSPYVGRFNISNIMAAMIAVWSKGTNLNEIINAVTELEPVEGRLEV--LDPS 342
Cdd:NF033197 235 -----VEIL-SKYPLRFKYGN--TEFEFNPLLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPGRMAVkkEGGV 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487747182 343 LPIDLI--------IDYAhTADGMNKLIDAVqpfvkqklIFLVGMAG-------ERDLTKTPEMGRVACRaDYVIFTPDn 407
Cdd:NF033197 307 VIVDNInpglnvkaIEYA-LDDALELLGDGT--------LVIGGDFGvvceeidIDKLSEVLKKYRPKID-ILVGVGTE- 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 487747182 408 panddpkmLTAELAKGATHNNYIEFDDRAEGIRHAIDIAEPGDTVVLASK 457
Cdd:NF033197 376 --------LGKRLKKYLDKLEGYEAGTLEEGLDDARELTGEGNTLVIYRK 417
|
|
| |
