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Conserved domains on  [gi|487750868|ref|WP_001832661|]
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MULTISPECIES: monovalent cation:proton antiporter family protein [Staphylococcus]

Protein Classification

monovalent cation:proton antiporter family protein( domain architecture ID 11422111)

monovalent cation:proton antiporter family protein such as Na/H antiporters which are key transporters in maintaining the pH of actively metabolising cells, and glutathione-regulated potassium-efflux system proteins that confer protection against electrophiles and catalyzes K+/H+ antiport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 4.24e-70

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


:

Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 231.58  E-value: 4.24e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   3 FLSLVIVVVAAFMTPIIVHRFNinfLPVVVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEIDFNAFKKD 82
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  83 SRPrqgedkhekdvpgHLKLALTVFAFIMMISVVLAFAFKWlgLVNDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475   83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGL--SLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 163 ILLVAVLADLFTMILLTVYGAIYGEG---GSTIWLTGILVVFTVVFYVIGVLFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475  148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 240 LVALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYgFFIPIFFIMVGVDLDIPSLIKEPsllLIIPVLIFSFII 319
Cdd:COG0475  228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487750868 320 SKLIPVFYIRRWF--DTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPVIFKKMFPI 393
Cdd:COG0475  304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 306-595 5.10e-18

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 85.12  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 306 LLLIIPVLIFSFIISKLIPVFYIrrWFDTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPV 385
Cdd:COG0569    3 ILLLLLVLLFAMGIEGLVLLDAL--YGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 386 IFKKMFPIPNEVGRRIEVSMIGKNQLTIPIAQNLTSQLYDISLYyRKDLSDSRKLSDDITMIEIAD-YEEDLLERLGLFE 464
Cdd:COG0569   81 ALRRRRMERGIKKLKMHVIIIGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIED 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 465 RDIVVCSTNDDHINKSVALMAKKHGVKRVICRLESTNEDPTLKHQGI-EVFSNYLSNKILLKSLIETPNMLNL--LSNVE 541
Cdd:COG0569  160 ADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGD 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750868 542 TSLYEIQMLNY-QYENIQLR--NFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLI 595
Cdd:COG0569  240 AEIVEVTVPEGsPLVGKTLKelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 4.24e-70

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 231.58  E-value: 4.24e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   3 FLSLVIVVVAAFMTPIIVHRFNinfLPVVVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEIDFNAFKKD 82
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  83 SRPrqgedkhekdvpgHLKLALTVFAFIMMISVVLAFAFKWlgLVNDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475   83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGL--SLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 163 ILLVAVLADLFTMILLTVYGAIYGEG---GSTIWLTGILVVFTVVFYVIGVLFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475  148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 240 LVALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYgFFIPIFFIMVGVDLDIPSLIKEPsllLIIPVLIFSFII 319
Cdd:COG0475  228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487750868 320 SKLIPVFYIRRWF--DTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPVIFKKMFPI 393
Cdd:COG0475  304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 6-388 2.20e-61

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 208.26  E-value: 2.20e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868    6 LVIVVVAAFMTPIIVHRFNInflPVVVAEILMGIVIGHSFLNLVERDAF-LNILSTLGFIFLMFLSGLEIDFNAFKKDSR 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKL---PPIVGLIIAGILLGPSGLGLISEVDEdLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   85 PrqgedkhekdvpgHLKLALTVFAFIMMISVVLAFAFKWLGLVNDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFIL 164
Cdd:pfam00999  78 S-------------ILLLALLGVLIPFVLIGLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  165 LVAVLADLFTMILLTVYGAIY---GEGGSTIWLTGILVVFTVVFYVIGVLFKRMSFLQ-KLMDGTTQIGIRAVFALIILL 240
Cdd:pfam00999 145 GESVLNDGVAVVLLAVLLALAqgvGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLItRFTDDDRELEVLLVLLLALLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  241 VALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYGFFIPIFFIMVGVDLDIPSLIkePSLLLIIPVLIFSFIIS 320
Cdd:pfam00999 225 ALLAEALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNPLFFVLVGLSLDLSSLL--LSVWILVLLALVAILLG 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  321 KLIPVFYIRR--WFDTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPVIFK 388
Cdd:pfam00999 303 RFLGVFLLLRllGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLK 372
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 11-296 7.66e-33

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 127.38  E-value: 7.66e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   11 VAAFMTPIIVHRFNInflPVVVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEIDFNAFKKDSRPRQGEd 90
Cdd:TIGR00932   2 LAAVLAVPLSRRLGI---PSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   91 khekdvpGHLKLALTVFAFIMMisvvLAFAFKWLGLVNdvLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLA 170
Cdd:TIGR00932  78 -------GVLQVLVPGVLLGLL----LGHLLGLALGAA--VVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  171 DLFTMILLTVYgAIYGEGGSTIWLTGILVVFTVVFYVIGVLFKRMSFLQKLMDGTTQIGIRAVFALIILLVAL-----AE 245
Cdd:TIGR00932 145 DIAVVPLLALL-PLLATSASTEHVALALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFgsayfAD 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 487750868  246 GVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGyGFFIPIFFIMVGVDLD 296
Cdd:TIGR00932 224 LLGLSMALGAFLAGVVLSESEYRHKLESDLEPIG-GVLLPLFFISVGMSVD 273
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 306-595 5.10e-18

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 85.12  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 306 LLLIIPVLIFSFIISKLIPVFYIrrWFDTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPV 385
Cdd:COG0569    3 ILLLLLVLLFAMGIEGLVLLDAL--YGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 386 IFKKMFPIPNEVGRRIEVSMIGKNQLTIPIAQNLTSQLYDISLYyRKDLSDSRKLSDDITMIEIAD-YEEDLLERLGLFE 464
Cdd:COG0569   81 ALRRRRMERGIKKLKMHVIIIGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIED 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 465 RDIVVCSTNDDHINKSVALMAKKHGVKRVICRLESTNEDPTLKHQGI-EVFSNYLSNKILLKSLIETPNMLNL--LSNVE 541
Cdd:COG0569  160 ADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGD 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750868 542 TSLYEIQMLNY-QYENIQLR--NFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLI 595
Cdd:COG0569  240 AEIVEVTVPEGsPLVGKTLKelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-386 1.62e-15

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 80.32  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   4 LSLVIVVVAAFMTPIIVHRFNinfLPVVVAEILMGIVIGHSFLNLVERDA----------FLNILSTLGFIFLMFLSGLE 73
Cdd:PLN03159  46 LQLTLVVVTTRLLVFILKPFR---QPRVISEILGGVILGPSVLGQSEVFAntifplrsvmVLETMANLGLLYFLFLVGVE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  74 IDFNAFKKDsrprqgedkhekdvpGHLKLALTVFAFIMMISVVLAFAF------KWLGLVNDVLLMVIIISTISLGVVVP 147
Cdd:PLN03159 123 MDISVIRRT---------------GKKALAIAIAGMALPFCIGLAFSFifhqvsRNVHQGTFILFLGVALSVTAFPVLAR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 148 TLKEMNIMRTTIGQFILLVAVLADLFTMILLTVYGAIyGEGGST----IWLTGILVVFTVV-FYVIGVLFKRMSFLQKLM 222
Cdd:PLN03159 188 ILAEIKLINTELGRIAMSAALVNDMCAWILLALAIAL-AENDSTslasLWVLLSSVAFVLFcFYVVRPGIWWIIRRTPEG 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 223 DGTTQIGIRAVFALIILLVALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYGFFIPIFFIMVGVDLDIpSLIK 302
Cdd:PLN03159 267 ETFSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNV-TKIQ 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 303 EPS----LLLIIPVLIFSFIISKLIPVFYIRRWFdtKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVI 378
Cdd:PLN03159 346 GPAtwglLVLVIIMASAGKIMGTIIIAFFYTMPF--REGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVA 423


                 ....*....
gi 487750868 379 -TCVFVPVI 386
Cdd:PLN03159 424 mTALITPVV 432
trkA PRK09496
Trk system potassium transporter TrkA;
454-608 1.21e-09

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 60.91  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 454 EDLLERLGLFERDIVVCSTNDDHINKSVALMAKKHGVKRVICRLESTNEDPTLKHQGIEVfsnYLS------NKILlkSL 527
Cdd:PRK09496 287 QELLEEEGIDEADAFIALTNDDEANILSSLLAKRLGAKKVIALVNRPAYVDLVEGLGIDI---AISprqataSEIL--RH 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 528 IETPNMLNLlsnveTSLYEIQMLNYQYE--------NIQLRNFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIV-TG 598
Cdd:PRK09496 362 VRRGDIVAV-----HSLRRGAAEAIEAVahetskvvGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVfVL 436

                        170
                 ....*....|
gi 487750868 599 TKEYVDELKQ 608
Cdd:PRK09496 437 DKKFVPDVEK 446
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 561-610 4.65e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 44.52  E-value: 4.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 487750868  561 NFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIVTGTKEYVDELKQEL 610
Cdd:pfam02080  21 NLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 4.24e-70

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 231.58  E-value: 4.24e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   3 FLSLVIVVVAAFMTPIIVHRFNinfLPVVVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEIDFNAFKKD 82
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  83 SRPrqgedkhekdvpgHLKLALTVFAFIMMISVVLAFAFKWlgLVNDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475   83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGL--SLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 163 ILLVAVLADLFTMILLTVYGAIYGEG---GSTIWLTGILVVFTVVFYVIGVLFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475  148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 240 LVALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYgFFIPIFFIMVGVDLDIPSLIKEPsllLIIPVLIFSFII 319
Cdd:COG0475  228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487750868 320 SKLIPVFYIRRWF--DTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPVIFKKMFPI 393
Cdd:COG0475  304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 6-388 2.20e-61

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 208.26  E-value: 2.20e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868    6 LVIVVVAAFMTPIIVHRFNInflPVVVAEILMGIVIGHSFLNLVERDAF-LNILSTLGFIFLMFLSGLEIDFNAFKKDSR 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKL---PPIVGLIIAGILLGPSGLGLISEVDEdLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   85 PrqgedkhekdvpgHLKLALTVFAFIMMISVVLAFAFKWLGLVNDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFIL 164
Cdd:pfam00999  78 S-------------ILLLALLGVLIPFVLIGLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  165 LVAVLADLFTMILLTVYGAIY---GEGGSTIWLTGILVVFTVVFYVIGVLFKRMSFLQ-KLMDGTTQIGIRAVFALIILL 240
Cdd:pfam00999 145 GESVLNDGVAVVLLAVLLALAqgvGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLItRFTDDDRELEVLLVLLLALLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  241 VALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYGFFIPIFFIMVGVDLDIPSLIkePSLLLIIPVLIFSFIIS 320
Cdd:pfam00999 225 ALLAEALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNPLFFVLVGLSLDLSSLL--LSVWILVLLALVAILLG 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  321 KLIPVFYIRR--WFDTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPVIFK 388
Cdd:pfam00999 303 RFLGVFLLLRllGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLK 372
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 11-296 7.66e-33

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 127.38  E-value: 7.66e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   11 VAAFMTPIIVHRFNInflPVVVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEIDFNAFKKDSRPRQGEd 90
Cdd:TIGR00932   2 LAAVLAVPLSRRLGI---PSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   91 khekdvpGHLKLALTVFAFIMMisvvLAFAFKWLGLVNdvLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLA 170
Cdd:TIGR00932  78 -------GVLQVLVPGVLLGLL----LGHLLGLALGAA--VVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  171 DLFTMILLTVYgAIYGEGGSTIWLTGILVVFTVVFYVIGVLFKRMSFLQKLMDGTTQIGIRAVFALIILLVAL-----AE 245
Cdd:TIGR00932 145 DIAVVPLLALL-PLLATSASTEHVALALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFgsayfAD 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 487750868  246 GVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGyGFFIPIFFIMVGVDLD 296
Cdd:TIGR00932 224 LLGLSMALGAFLAGVVLSESEYRHKLESDLEPIG-GVLLPLFFISVGMSVD 273
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 3-400 1.37e-28

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 120.46  E-value: 1.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   3 FLSLVIVVVAAFMTPIIVHRFNinfLPVVVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEIDFNAFKKD 82
Cdd:COG4651    7 ITTIALILGLAAVLGLLAQRLR---QPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  83 SRprqgedkheKDVPGhlKLALTVFAFIMMISVVLAFAFKWL-GLVNDVLLMVIiiSTIslgVVVPTLKEMNIMRTTIGQ 161
Cdd:COG4651   84 RK---------IALPG--ALLQIALTTLLGFGIALLLGWSLGeSLVFGLALSLS--STV---VLLKLLEDRGELDTLHGR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 162 FILLVAVLADLFTMILLTVYGAIYGEGGSTIWLTGILVVFTVVFYVIGVLFKRMsFLQKLMDGTTQIGIRAVFALIILLV 241
Cdd:COG4651  148 IAVGWLIVQDLAVVLMLVLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRR-VIPWLLHRVARTRSRELFLLAVLAI 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 242 ALAEGVGAEYI-----LGAFLAGVVVSLLKPNEEMVEKLDSFGYgFFIPIFFIMVGVDLDIPSLIKEPSLLLIIPVLIfs 316
Cdd:COG4651  227 CLGVAYLAALFglsfaLGAFLAGMVLAESEYSHQAAAELLPLRD-AFAVLFFVSVGMLFDPSFLLENPLPVLALLLIV-- 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 317 fIISKLIPVFYIRRWF--DTKTTIASAFLLT--STLSLVIAAakIAEKLKAISPETSGILILSAVITCVFVPVIFKKMFP 392
Cdd:COG4651  304 -LIGKPLIAFLIVLALgyPLRTALLVGLSLAqiGEFSFILAA--LGLSLGLLSEEAYQLILAVAILTIALSPYLIALADP 380


                 ....*...
gi 487750868 393 IPNEVGRR 400
Cdd:COG4651  381 LYARLERR 388
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 306-595 5.10e-18

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 85.12  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 306 LLLIIPVLIFSFIISKLIPVFYIrrWFDTKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVITCVFVPV 385
Cdd:COG0569    3 ILLLLLVLLFAMGIEGLVLLDAL--YGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 386 IFKKMFPIPNEVGRRIEVSMIGKNQLTIPIAQNLTSQLYDISLYyRKDLSDSRKLSDDITMIEIAD-YEEDLLERLGLFE 464
Cdd:COG0569   81 ALRRRRMERGIKKLKMHVIIIGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIED 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 465 RDIVVCSTNDDHINKSVALMAKKHGVKRVICRLESTNEDPTLKHQGI-EVFSNYLSNKILLKSLIETPNMLNL--LSNVE 541
Cdd:COG0569  160 ADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGD 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750868 542 TSLYEIQMLNY-QYENIQLR--NFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLI 595
Cdd:COG0569  240 AEIVEVTVPEGsPLVGKTLKelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-386 1.62e-15

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 80.32  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   4 LSLVIVVVAAFMTPIIVHRFNinfLPVVVAEILMGIVIGHSFLNLVERDA----------FLNILSTLGFIFLMFLSGLE 73
Cdd:PLN03159  46 LQLTLVVVTTRLLVFILKPFR---QPRVISEILGGVILGPSVLGQSEVFAntifplrsvmVLETMANLGLLYFLFLVGVE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  74 IDFNAFKKDsrprqgedkhekdvpGHLKLALTVFAFIMMISVVLAFAF------KWLGLVNDVLLMVIIISTISLGVVVP 147
Cdd:PLN03159 123 MDISVIRRT---------------GKKALAIAIAGMALPFCIGLAFSFifhqvsRNVHQGTFILFLGVALSVTAFPVLAR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 148 TLKEMNIMRTTIGQFILLVAVLADLFTMILLTVYGAIyGEGGST----IWLTGILVVFTVV-FYVIGVLFKRMSFLQKLM 222
Cdd:PLN03159 188 ILAEIKLINTELGRIAMSAALVNDMCAWILLALAIAL-AENDSTslasLWVLLSSVAFVLFcFYVVRPGIWWIIRRTPEG 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 223 DGTTQIGIRAVFALIILLVALAEGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGYGFFIPIFFIMVGVDLDIpSLIK 302
Cdd:PLN03159 267 ETFSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNV-TKIQ 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 303 EPS----LLLIIPVLIFSFIISKLIPVFYIRRWFdtKTTIASAFLLTSTLSLVIAAAKIAEKLKAISPETSGILILSAVI 378
Cdd:PLN03159 346 GPAtwglLVLVIIMASAGKIMGTIIIAFFYTMPF--REGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVA 423


                 ....*....
gi 487750868 379 -TCVFVPVI 386
Cdd:PLN03159 424 mTALITPVV 432
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 5-386 2.95e-12

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 69.64  E-value: 2.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   5 SLVIVVVAAFMTPIIVhRFNinfLPVVVAEILMGIVIGHSFLNLV-ERDAFLNiLSTLGFIFLMFLSGLEIDFNAFKKDS 83
Cdd:PRK03562  10 ALIYLGAAVLIVPIAV-RLG---LGSVLGYLIAGCIIGPWGLRLVtDVESILH-FAEFGVVLMLFVIGLELDPQRLWKLR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  84 RPRQGEdkhekdvpGHLKL---ALTVFAFIMmisvvlAFAFKWLglVNDVLLMVIIIStiSLGVVVPTLKEMNIMRTTIG 160
Cdd:PRK03562  85 RSIFGG--------GALQMvacGGLLGLFCM------LLGLRWQ--VALLIGLGLALS--STAIAMQAMNERNLMVTQMG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 161 Q--F-ILL---VAVLADLFTMILLTVYGAiyGEGGSTIWLTGILVVFTVVFYVIGVLFkrmsFLQKLMDGTTQIGIRAVF 234
Cdd:PRK03562 147 RsaFaILLfqdIAAIPLVAMIPLLAASGA--STTLGAFALSALKVAGALALVVLGGRY----VTRPALRFVARSGLREVF 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 235 -ALIILLV----ALAEGVGAEYILGAFLAGVvvsLLKPNE---EMVEKLDSFGyGFFIPIFFIMVGVDLDIPSLIKEPSL 306
Cdd:PRK03562 221 tAVALFLVfgfgLLMEEVGLSMALGAFLAGV---LLASSEyrhALESDIEPFK-GLLLGLFFIAVGMSIDFGTLLENPLR 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 307 LLIipvLIFSFIISKLIPVFYI----------RRWFdtkttiasAFLLT--STLSLVIAAAkiAEKLKAISPETSGILIL 374
Cdd:PRK03562 297 ILI---LLLGFLAIKIAMLWLLarplgvprkqRRWF--------AVLLGqgGEFAFVVFGA--AQMANVLEPEWAKLLTL 363

                        410
                 ....*....|..
gi 487750868 375 SAVITCVFVPVI 386
Cdd:PRK03562 364 AVALSMAATPLL 375
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
1-467 4.14e-10

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 62.29  E-value: 4.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   1 ME-FLSLVIVVVAAFMTPIIVHRFNInflPVVVAEILMGIVIGHsFLNLVERDAFLNI--LSTLGFIFLMFLSGLEIDFN 77
Cdd:COG0025    1 MElLLLILLLLLLGLLSQWLARRLKL---PAPLLLLLAGILLGP-GLGLELDPELGDLepLLELFLPPLLFEAALNLDLR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  78 AFKKDSRPrqgedkhekdvpghlKLALTVFAFIMMISVVLAFAFKWLGLVNDV-LLMVIIISTISLGVVVPTLKEMNImR 156
Cdd:COG0025   77 ELRRNGRP---------------ILRLAVVGVLLTTLAVALAAHWLLGLPLAAaLLLGAILAPTDPVAVSPILRRLGV-P 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 157 TTIGQFILLVAVLADLFTMILLTVYGAIYGEGGSTIWLTGILVVFTVVF-----YVIGVLFKRMsfLQKLMDGTTQIGIr 231
Cdd:COG0025  141 KRLRTILEGESLLNDATALVLFVLALAAALGGGFSLGEALLDFLLAILGgilvgLLLGWLLGRL--LRRLPDPLLEILL- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 232 aVFALIILLVALAEGVGAEYILGAFLAGVVVSLLKP---NEEMVEKLDSF----GYgFFIPIFFIMVGVDLDIPSLikEP 304
Cdd:COG0025  218 -TLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRrslSPETRLQLLEFwetlEF-LLNSLLFVLLGAQLPLILL--GA 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 305 SLLLIIPVLIFSFIISKLIPVFYIRRWFDTKTT--------------IASAFLLTSTLSLVIAAAKIAEKLKAIspeTSG 370
Cdd:COG0025  294 LGLGGILLVLLALLVVRPLWVFLSLALRGSRLSwrerlflswggprgIVSLALALSLPLHGGAGFPGRDLILAL---AFG 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 371 ILILSAVITCVFVPVIFKKM-FPIPNEVGRRIEVSMIGKNQLTIPIAQNLTSQLYDISLYYRKDLSDSRKLSDDITMIEI 449
Cdd:COG0025  371 VILLTLVLQGLTLPPLARRLgLREDEPEGEELEAALARAALLELLAAELLADDEEVVLRAARRARRRREAAELLSEEAEE 450

                        490
                 ....*....|....*...
gi 487750868 450 ADYEEDLLERLGLFERDI 467
Cdd:COG0025  451 ELDEDLLRLLLALLRLRL 468
trkA PRK09496
Trk system potassium transporter TrkA;
454-608 1.21e-09

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 60.91  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 454 EDLLERLGLFERDIVVCSTNDDHINKSVALMAKKHGVKRVICRLESTNEDPTLKHQGIEVfsnYLS------NKILlkSL 527
Cdd:PRK09496 287 QELLEEEGIDEADAFIALTNDDEANILSSLLAKRLGAKKVIALVNRPAYVDLVEGLGIDI---AISprqataSEIL--RH 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 528 IETPNMLNLlsnveTSLYEIQMLNYQYE--------NIQLRNFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIV-TG 598
Cdd:PRK09496 362 VRRGDIVAV-----HSLRRGAAEAIEAVahetskvvGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVfVL 436

                        170
                 ....*....|
gi 487750868 599 TKEYVDELKQ 608
Cdd:PRK09496 437 DKKFVPDVEK 446
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 7-330 4.97e-09

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 59.27  E-value: 4.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   7 VIVVVAAFMTPIIVHRFNINflpVVVAEILMGIVIGHSFLNLV-ERDAFLNiLSTLGFIFLMFLSGLEIDFNAFKKDSRP 85
Cdd:PRK03659  11 VLFLFAAVVAVPLAQRLGIG---AVLGYLLAGIAIGPWGLGFIsDVDEILH-FSELGVVFLMFIIGLELNPSKLWQLRRS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  86 RQGedkhekdvpghLKLALTVFAFIMMISVVLAFAFKWLGLVndVLLMVIIISTISLGVVVPTLKEMNimRTTIGQFILL 165
Cdd:PRK03659  87 IFG-----------VGAAQVLLSAAVLAGLLMLTDFSWQAAV--VGGIGLAMSSTAMALQLMREKGMN--RSESGQLGFS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 166 VAVLADLFTMILLTVYGAIYGEGGSTI-WLTGILVVFTVVFYVIGVLFkrmsFLQKLMDGTTQIGIRAVFALIILLVALA 244
Cdd:PRK03659 152 VLLFQDLAVIPALALVPLLAGSADEHFdWMKIGMKVLAFAGMLIGGRY----LLRPLFRFIAASGVREVFTAAALLLVLG 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 245 -----EGVGAEYILGAFLAGVVVSLLKPNEEMVEKLDSFGyGFFIPIFFIMVGVDLDIPSLIKEPSLLLI---IPVLIFS 316
Cdd:PRK03659 228 salfmDALGLSMALGTFIAGVLLAESEYRHELEIAIEPFK-GLLLGLFFISVGMALNLGVLYTHLLWVLIsvvVLVAVKG 306

                        330
                 ....*....|....
gi 487750868 317 FIISKLIPVFYIRR 330
Cdd:PRK03659 307 LVLYLLARLYGLRS 320
trkA PRK09496
Trk system potassium transporter TrkA;
455-610 9.42e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 54.74  E-value: 9.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 455 DLLERLGLFERDIVVCSTNDDHINKSVALMAKK-HGVKRVICRLEST--NEDPTLKHQ---GIEVFSN---YLSNKILlk 525
Cdd:PRK09496  56 DVLREAGAEDADLLIAVTDSDETNMVACQIAKSlFGAPTTIARVRNPeyAEYDKLFSKealGIDLLISpelLVAREIA-- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 526 SLIETPNMLN-------LLSNVETSLYEIQMLNYQYENiQLRNFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIVTG 598
Cdd:PRK09496 134 RLIEYPGALDveefadgRVQLVEVKVYEGSPLVGKPLS-DLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIG 212

                        170
                 ....*....|..
gi 487750868 599 TKEYVDELKQEL 610
Cdd:PRK09496 213 AREHIRAVMSEF 224
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 5-387 1.57e-07

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 54.33  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868   5 SLVIVVVAAFMTPIIVHRFNINFLpvvVAEILMGIVIGHSFLNLVERDAFLNILSTLGFIFLMFLSGLEI---DFNAFKK 81
Cdd:PRK10669  10 TIVGGLVLAFILGMLANRLRISPL---VGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFslkDLMAVKS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868  82 DSrprqgedkhekdVPGhlklALTVFAFIMMISVVLAFAFKW---LGLVNDVLLmviiiSTISLGVVVPTLKEMNIMRTT 158
Cdd:PRK10669  87 IA------------IPG----AIAQIAVATLLGMALSAVLGWslmTGIVFGLCL-----STASTVVLLRALEERQLIDSQ 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 159 IGQFI---LLVAVLADLFTMILLTVYGAIYGEGGSTI--------WLTGILVVFTVVFYVIGvlfKRMsfLQKLMDGTTQ 227
Cdd:PRK10669 146 RGQIAigwLIVEDLVMVLTLVLLPAVAGMMEQGDVGFatlavdlgITIGKVIAFIAIMMLVG---RRL--VPWILARSAA 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 228 IGIRAVFALIILLVALAEGVGA------EYILGAFLAGVVV--SLL--KPNEEMVEKLDSFGYgffipIFFIMVGVDLDI 297
Cdd:PRK10669 221 TGSRELFTLSVLALALGIAFGAvelfdvSFALGAFFAGMVLneSELshRAAHDTLPLRDAFAV-----LFFVSVGMLFDP 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750868 298 PSLIKEPSLLLIIPVLIfsfIISKLIPVFYIRRWFD----TKTTIASAFLLTSTLSLVIAAAKIAekLKAISPETSGILI 373
Cdd:PRK10669 296 MILIQQPLAVLATLAII---VFGKSLAAFFLVRLFGhsrrTALTIAASLAQIGEFAFILAGLGMA--LNLLPQAGQNLVL 370

                        410
                 ....*....|....
gi 487750868 374 LSAVITCVFVPVIF 387
Cdd:PRK10669 371 AGAILSIMLNPVLF 384
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 561-610 4.65e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 44.52  E-value: 4.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 487750868  561 NFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIVTGTKEYVDELKQEL 610
Cdd:pfam02080  21 NLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 558-608 3.10e-03

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 40.48  E-value: 3.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 487750868 558 QLRNFPFGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIVTGTKEYVDELKQ 608
Cdd:COG3263  430 TLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 564-610 3.20e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 40.49  E-value: 3.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 487750868 564 FGGDIIFVRIIRDNDSIVPHGDTQLRYKDRLIVTGTKEYVDELKQEL 610
Cdd:COG2985  226 LGTRVVISRIRRGGEIIVPTPDTVLQEGDIVLVVGTREALEAAEALL 272
PRK05326 PRK05326
potassium/proton antiporter;
567-610 3.31e-03

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 40.57  E-value: 3.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 487750868 567 DIIFVRIIRDNDSIVPHGDTQLRYKDRLIVTGTKEYVDELKQEL 610
Cdd:PRK05326 440 GALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLF 483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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