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Conserved domains on  [gi|488429515|ref|WP_002498900|]
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IS6 family transposase, partial [Staphylococcus epidermidis]

Protein Classification

IS6 family transposase( domain architecture ID 16670614)

IS6 family transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0032196|GO:0015074|GO:0006310|GO:0004803
PubMed:  33757578|31486766|20215432

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS6 NF033587
IS6 family transposase;
4-109 7.69e-54

IS6 family transposase;


:

Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 166.59  E-value: 7.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515   4 FRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEYAPILYQIWKQKHKKAYYKWHVDETYIKIK 83
Cdd:NF033587   1 FKRERFPPEIILLAVRLYLRGPLSLRDVEEILAERGVSVSHSTIYRWVHKYAPQLAKRLRRRKPRPPDSWAVDETVIKIN 80

                         90       100
                 ....*....|....*....|....*.
gi 488429515  84 GKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:NF033587  81 GKWYYLYRAVDKEGETLDFLLSPRRD 106
 
Name Accession Description Interval E-value
transpos_IS6 NF033587
IS6 family transposase;
4-109 7.69e-54

IS6 family transposase;


Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 166.59  E-value: 7.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515   4 FRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEYAPILYQIWKQKHKKAYYKWHVDETYIKIK 83
Cdd:NF033587   1 FKRERFPPEIILLAVRLYLRGPLSLRDVEEILAERGVSVSHSTIYRWVHKYAPQLAKRLRRRKPRPPDSWAVDETVIKIN 80

                         90       100
                 ....*....|....*....|....*.
gi 488429515  84 GKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:NF033587  81 GKWYYLYRAVDKEGETLDFLLSPRRD 106
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
1-109 5.65e-51

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 160.46  E-value: 5.65e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515   1 MNYFRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEYAPILYQIWKQKHKKAYYKWHVDETYI 80
Cdd:COG3316    1 MVDFKGRRFPPEIILLAVRLYLRYGLSLRDVEEMLAERGVDVSHSTIYRWVQKFAPLIAKRLRRRRPPLSDSWHVDETYI 80

                         90       100
                 ....*....|....*....|....*....
gi 488429515  81 KIKGKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:COG3316   81 KIKGKWHYLYRAVDAEGRILDFLLSPRRD 109
DDE_Tnp_IS240 pfam13610
DDE domain; This DDE domain is found in a wide variety of transposases including those found ...
 73-109 3.20e-14

DDE domain; This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.


Pssm-ID: 433347 [Multi-domain]  Cd Length: 138  Bit Score: 63.92  E-value: 3.20e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 488429515   73 WHVDETYIKIKGKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:pfam13610   3 WRVDETYVKVKGKWHYVYRAVDKEGNTLDFYVSKRRD 39
transpos_IS481 NF033577
IS481 family transposase; null
 10-94 8.25e-05

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 39.88  E-value: 8.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515  10 DKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEY--APILYQIWKQKHKKAY------YKWHVDETYI- 80
Cdd:NF033577  60 SPETEARILALRRELRLGPRRIAYELERQGPGVSRSTVHRILRRHglSRLRALDRKTGKVKRYerahpgELWHIDIKKLg 139

                         90
                 ....*....|....*
gi 488429515  81 KIKGK-WFYLYRAID 94
Cdd:NF033577 140 RIPDVgRLYLHTAID 154
DrmE_fam NF038316
DrmE family protein; Members of this extremely diverse family include DrmE, a protein of ...
 20-53 2.99e-03

DrmE family protein; Members of this extremely diverse family include DrmE, a protein of unknown function sometimes found as part of a DISARM antiphage defense systems.


Pssm-ID: 468470  Cd Length: 832  Bit Score: 35.75  E-value: 2.99e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 488429515  20 YYLRYALSYRDISEILRERGVTVHHSTVYRWVQE 53
Cdd:NF038316 694 YMEKNGLSYNDLAKKLKKLGCKKHEATIRNWLDD 727
 
Name Accession Description Interval E-value
transpos_IS6 NF033587
IS6 family transposase;
4-109 7.69e-54

IS6 family transposase;


Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 166.59  E-value: 7.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515   4 FRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEYAPILYQIWKQKHKKAYYKWHVDETYIKIK 83
Cdd:NF033587   1 FKRERFPPEIILLAVRLYLRGPLSLRDVEEILAERGVSVSHSTIYRWVHKYAPQLAKRLRRRKPRPPDSWAVDETVIKIN 80

                         90       100
                 ....*....|....*....|....*.
gi 488429515  84 GKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:NF033587  81 GKWYYLYRAVDKEGETLDFLLSPRRD 106
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
1-109 5.65e-51

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 160.46  E-value: 5.65e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515   1 MNYFRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEYAPILYQIWKQKHKKAYYKWHVDETYI 80
Cdd:COG3316    1 MVDFKGRRFPPEIILLAVRLYLRYGLSLRDVEEMLAERGVDVSHSTIYRWVQKFAPLIAKRLRRRRPPLSDSWHVDETYI 80

                         90       100
                 ....*....|....*....|....*....
gi 488429515  81 KIKGKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:COG3316   81 KIKGKWHYLYRAVDAEGRILDFLLSPRRD 109
DDE_Tnp_IS240 pfam13610
DDE domain; This DDE domain is found in a wide variety of transposases including those found ...
 73-109 3.20e-14

DDE domain; This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.


Pssm-ID: 433347 [Multi-domain]  Cd Length: 138  Bit Score: 63.92  E-value: 3.20e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 488429515   73 WHVDETYIKIKGKWFYLYRAIDADGHTLDIWLRKQRD 109
Cdd:pfam13610   3 WRVDETYVKVKGKWHYVYRAVDKEGNTLDFYVSKRRD 39
transpos_IS481 NF033577
IS481 family transposase; null
 10-94 8.25e-05

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 39.88  E-value: 8.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515  10 DKDVITVAVGYYLRYALSYRDISEILRERGVTVHHSTVYRWVQEY--APILYQIWKQKHKKAY------YKWHVDETYI- 80
Cdd:NF033577  60 SPETEARILALRRELRLGPRRIAYELERQGPGVSRSTVHRILRRHglSRLRALDRKTGKVKRYerahpgELWHIDIKKLg 139

                         90
                 ....*....|....*
gi 488429515  81 KIKGK-WFYLYRAID 94
Cdd:NF033577 140 RIPDVgRLYLHTAID 154
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
28-95 1.90e-04

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 38.98  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488429515  28 YRDISEILRERGVTVHHSTVYRWVQEYApiLYQIWKQKHKKAYY--------------------KWHVDETYIKIKGKWF 87
Cdd:COG2801   89 YRRITAELRREGIAVNRKRVRRLMRELG--LQARRRRKKKYTTYsghggpiapnllftatapnqVWVTDITYIPTAEGWL 166


                 ....*...
gi 488429515  88 YLYRAIDA 95
Cdd:COG2801  167 YLAAVIDL 174
DrmE_fam NF038316
DrmE family protein; Members of this extremely diverse family include DrmE, a protein of ...
 20-53 2.99e-03

DrmE family protein; Members of this extremely diverse family include DrmE, a protein of unknown function sometimes found as part of a DISARM antiphage defense systems.


Pssm-ID: 468470  Cd Length: 832  Bit Score: 35.75  E-value: 2.99e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 488429515  20 YYLRYALSYRDISEILRERGVTVHHSTVYRWVQE 53
Cdd:NF038316 694 YMEKNGLSYNDLAKKLKKLGCKKHEATIRNWLDD 727
HemD COG1587
Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III ...
 21-51 4.15e-03

Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III synthase is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 441195  Cd Length: 229  Bit Score: 34.88  E-value: 4.15e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 488429515  21 YLRYALSYRDISEILRERGVTVHHSTVYRWV 51
Cdd:COG1587  130 IPRGDGGREDLAETLRAAGAEVDEVEVYRTV 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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