NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488866145|ref|WP_002778384|]
View 

MULTISPECIES: fumarate reductase cytochrome b subunit [Campylobacter]

Protein Classification

fumarate reductase cytochrome b subunit( domain architecture ID 10793825)

fumarate reductase cytochrome b subunit is a component of the fumarate reductase enzyme complex, which is required for fumarate respiration

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13553 PRK13553
fumarate reductase cytochrome b subunit;
1-259 3.80e-145

fumarate reductase cytochrome b subunit;


:

Pssm-ID: 237423  Cd Length: 258  Bit Score: 406.70  E-value: 3.80e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145   1 MSELIEGYLGKSIDGKKSKMPAKLDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELKFIYNdPMMSYITSF 80
Cdd:PRK13553   1 MEELIEGYLGKSIEGKKSRIPAKLDFLQSATGLFLGLFMWAHMFFVSTILISDDAMYKVAKFFEGSFFFK-AGEPALVSF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  81 LAACVLVVFFVHALLAMRKFPINFRQYQILRTHAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGD 160
Cdd:PRK13553  80 VAAGVILIFVVHAFLAMRKFPINYRQYQIFRTHKHLMKHGDTSLWFIQAFTGFAMFFLASVHLYVMLTNPDKIGPYGSSD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 161 RVINHFMWLFYIALLICVELHGSIGLYRLCVKWGWFEAKDVKdirKSRKKLKMAKWIISIFFLVLGVLSLAAFAKIGFEN 240
Cdd:PRK13553 160 RVVSQNMWLLYIVLLFAVELHGSIGLYRLAVKWGWFEGKNPK---ESRKKLKKVKWALSVFFLVLGLLTLAAYIKIGYEN 236

                        250       260
                 ....*....|....*....|.
gi 488866145 241 YQ--SQTTAMVKTYNGANYEY 259
Cdd:PRK13553 237 ADngIETYAPTIQADGKFYEE 257
 
Name Accession Description Interval E-value
PRK13553 PRK13553
fumarate reductase cytochrome b subunit;
1-259 3.80e-145

fumarate reductase cytochrome b subunit;


Pssm-ID: 237423  Cd Length: 258  Bit Score: 406.70  E-value: 3.80e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145   1 MSELIEGYLGKSIDGKKSKMPAKLDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELKFIYNdPMMSYITSF 80
Cdd:PRK13553   1 MEELIEGYLGKSIEGKKSRIPAKLDFLQSATGLFLGLFMWAHMFFVSTILISDDAMYKVAKFFEGSFFFK-AGEPALVSF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  81 LAACVLVVFFVHALLAMRKFPINFRQYQILRTHAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGD 160
Cdd:PRK13553  80 VAAGVILIFVVHAFLAMRKFPINYRQYQIFRTHKHLMKHGDTSLWFIQAFTGFAMFFLASVHLYVMLTNPDKIGPYGSSD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 161 RVINHFMWLFYIALLICVELHGSIGLYRLCVKWGWFEAKDVKdirKSRKKLKMAKWIISIFFLVLGVLSLAAFAKIGFEN 240
Cdd:PRK13553 160 RVVSQNMWLLYIVLLFAVELHGSIGLYRLAVKWGWFEGKNPK---ESRKKLKKVKWALSVFFLVLGLLTLAAYIKIGYEN 236

                        250       260
                 ....*....|....*....|.
gi 488866145 241 YQ--SQTTAMVKTYNGANYEY 259
Cdd:PRK13553 237 ADngIETYAPTIQADGKFYEE 257
QFR_TypeB_TM cd00581
Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the ...
 24-237 3.81e-93

Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone oxidoreductase (SQR). QFRs oxidize low potential quinols such as menaquinol and rhodoquinol and are involved in anaerobic respiration with fumarate as the terminal electron acceptor. SQR and QFR share a common subunit arrangement, composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunit. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron donor (quinol). The Type B enzyme from Desulfovibrio gigas is capable of fumarate reduction and succinate oxidation.


Pssm-ID: 238325  Cd Length: 206  Bit Score: 273.05  E-value: 3.81e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  24 LDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELKFIYnDPMMSYITSFLAACVLVVFFVHALLAMRKFPIN 103
Cdd:cd00581    1 LDFLQSATGLFLALFMWAHMLFVSSILLGKEAMYWVARFFEGAFFF-GHGYPWVVSVVAAIVFALFVAHAFLALRKFPAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 104 FRQYQILRTHAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGDRVINHFMWLFYIALLICVELHGS 183
Cdd:cd00581   80 YRQWRAFRRHMQLMKHGDTSLWWIQAVTGFVLFFLASAHLYEMLTNPEIIGPHTSAYRVVHGGWWLLYLALLPAVELHGG 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488866145 184 IGLYRLCVKWGWFEakdvkdiRKSRKKLKMAKWIISIFFLVLGVLSLAAFAKIG 237
Cdd:cd00581  160 IGLYRLAVKWGWFA-------SESRKRLRRIKNVLSAFFLVLGLLTLLAYIKIG 206
Sdh_cyt pfam01127
Succinate dehydrogenase/Fumarate reductase transmembrane subunit; This family includes a ...
 119-225 5.40e-10

Succinate dehydrogenase/Fumarate reductase transmembrane subunit; This family includes a transmembrane protein from both the Succinate dehydrogenase and Fumarate reductase complexes.


Pssm-ID: 426067  Cd Length: 122  Bit Score: 55.85  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  119 HGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGDRVINHF---MWLFYIALLICVEL-HGSIGLYRLCVKWG 194
Cdd:pfam01127  17 HLTTWLSILHRITGVALAVLGLIFLLLWLLLLLSLLGPESYATVVAWLaspVKLILLLLLLLALFyHAANGIRHLIWDVG 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 488866145  195 WFeakdvKDIRKSRKKLKMAKWIISIFFLVL 225
Cdd:pfam01127  97 FG-----LELKTVRKSGAAVLALSVVLVIVL 122
SdhD COG2142
Succinate dehydrogenase, hydrophobic anchor subunit [Energy production and conversion];
125-234 2.74e-04

Succinate dehydrogenase, hydrophobic anchor subunit [Energy production and conversion];


Pssm-ID: 441745  Cd Length: 124  Bit Score: 39.81  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 125 WLVQAFTGFVMFFLGSAHLIFVITNGDkISADMSGDRVINHFMWLFYIALLICVELHGSIGL------YRLCVKWgwfea 198
Cdd:COG2142   23 WLLQRVTAVALVVLVLWFLFFLLSLPG-ADYAEVAAWFASPFWAILTLLFLLSALYHAWLGLrvviedYVHGTGL----- 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488866145 199 kdvkdirksRKKLKMAKWIISIFFLVLGVLSLAAFA 234
Cdd:COG2142   97 ---------RLALLLLLTLALVALAAAGVFALLRIA 123
sdhC_b558_fam TIGR02046
succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; This family ...
 29-195 6.50e-03

succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; This family consists of the succinate dehydrogenase subunit C of Bacillus subtilis, designated cytochrome b-558, and related sequences that include a fumarate reductase subunit C. This subfamily is only weakly similar to the main group of succinate dehydrogenase cytochrome b subunits described by pfam01127, so that some members score above the gathering threshold and some do not. [Energy metabolism, TCA cycle]


Pssm-ID: 131101 [Multi-domain]  Cd Length: 214  Bit Score: 37.07  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145   29 SASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFlelkfiyndpmMSYITSFLAACVLVVFFVHALLAMRKFPINFRQYQ 108
Cdd:TIGR02046  10 ALTGLVLLLFLVVHMVGNLFALFGAEAFNAAAHF-----------LRSLPFRLWLERIILFVPFILHAVYAVILSIRNKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  109 ILR--THAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLI---FVITNGDKISADMSG----DRVINHF----MWLFYIALL 175
Cdd:TIGR02046  79 NARpyRYMHKGRPGVSWASRTMRVTGIIVLIFIGWHVLdftIGAQMGEIFHMGVARhdgyDMVVLTFsspiMLSIYIVAM 158

                         170       180
                  ....*....|....*....|
gi 488866145  176 ICVELHGSIGLYRLCVKWGW 195
Cdd:TIGR02046 159 LALGFHLSHGLWSAAQTLGL 178
 
Name Accession Description Interval E-value
PRK13553 PRK13553
fumarate reductase cytochrome b subunit;
1-259 3.80e-145

fumarate reductase cytochrome b subunit;


Pssm-ID: 237423  Cd Length: 258  Bit Score: 406.70  E-value: 3.80e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145   1 MSELIEGYLGKSIDGKKSKMPAKLDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELKFIYNdPMMSYITSF 80
Cdd:PRK13553   1 MEELIEGYLGKSIEGKKSRIPAKLDFLQSATGLFLGLFMWAHMFFVSTILISDDAMYKVAKFFEGSFFFK-AGEPALVSF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  81 LAACVLVVFFVHALLAMRKFPINFRQYQILRTHAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGD 160
Cdd:PRK13553  80 VAAGVILIFVVHAFLAMRKFPINYRQYQIFRTHKHLMKHGDTSLWFIQAFTGFAMFFLASVHLYVMLTNPDKIGPYGSSD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 161 RVINHFMWLFYIALLICVELHGSIGLYRLCVKWGWFEAKDVKdirKSRKKLKMAKWIISIFFLVLGVLSLAAFAKIGFEN 240
Cdd:PRK13553 160 RVVSQNMWLLYIVLLFAVELHGSIGLYRLAVKWGWFEGKNPK---ESRKKLKKVKWALSVFFLVLGLLTLAAYIKIGYEN 236

                        250       260
                 ....*....|....*....|.
gi 488866145 241 YQ--SQTTAMVKTYNGANYEY 259
Cdd:PRK13553 237 ADngIETYAPTIQADGKFYEE 257
QFR_TypeB_TM cd00581
Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the ...
 24-237 3.81e-93

Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone oxidoreductase (SQR). QFRs oxidize low potential quinols such as menaquinol and rhodoquinol and are involved in anaerobic respiration with fumarate as the terminal electron acceptor. SQR and QFR share a common subunit arrangement, composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunit. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron donor (quinol). The Type B enzyme from Desulfovibrio gigas is capable of fumarate reduction and succinate oxidation.


Pssm-ID: 238325  Cd Length: 206  Bit Score: 273.05  E-value: 3.81e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  24 LDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELKFIYnDPMMSYITSFLAACVLVVFFVHALLAMRKFPIN 103
Cdd:cd00581    1 LDFLQSATGLFLALFMWAHMLFVSSILLGKEAMYWVARFFEGAFFF-GHGYPWVVSVVAAIVFALFVAHAFLALRKFPAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 104 FRQYQILRTHAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGDRVINHFMWLFYIALLICVELHGS 183
Cdd:cd00581   80 YRQWRAFRRHMQLMKHGDTSLWWIQAVTGFVLFFLASAHLYEMLTNPEIIGPHTSAYRVVHGGWWLLYLALLPAVELHGG 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488866145 184 IGLYRLCVKWGWFEakdvkdiRKSRKKLKMAKWIISIFFLVLGVLSLAAFAKIG 237
Cdd:cd00581  160 IGLYRLAVKWGWFA-------SESRKRLRRIKNVLSAFFLVLGLLTLLAYIKIG 206
PRK13554 PRK13554
fumarate reductase cytochrome b-556 subunit; Provisional
 22-239 3.32e-46

fumarate reductase cytochrome b-556 subunit; Provisional


Pssm-ID: 237424  Cd Length: 241  Bit Score: 154.52  E-value: 3.32e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  22 AKLDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELK-FIYNDPMMSYITSFLAACVLVVFFVHALLAMRKF 100
Cdd:PRK13554  22 AKADKLQSATGIMLGCFLLLHMHFESSILLGKEAFYHVVQFLEGGmFSSTGHGFPIVTKVFSVFMLLVVIVHAAVALRRF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 101 PINFRQYQILRTHAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDkISADMSGDRVINHFMWLFYIALLICVEL 180
Cdd:PRK13554 102 PAQLGQWRALRSHMGSIKHKDTHAWFWQLITGFILFFLVPVHLFTMILNPE-IGPHLSAERVYHDNAWLLYALLLPAVVI 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488866145 181 HGSIGLYRLCVKWGWfeakdvkdIRKSRKKLKMAKWIIsIFFLVLGVLSLAAFAKIGFE 239
Cdd:PRK13554 181 HAMIGLYRVAVKWGL--------TTNRSGLRKVAKVLI-IYLLCLGTLSLVSYIFIGSE 230
SQR_QFR_TypeB_TM cd03526
Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) Type B subfamily, ...
 24-232 9.34e-35

Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR, also called succinate dehydrogenase or Complex II, is part of the citric acid cycle and the aerobic respiratory chain, while QFR is involved in anaerobic respiration with fumarate as the terminal electron acceptor. SQR and QFR share a common subunit arrangement, composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Type B proteins contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunits. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron donor/acceptor (quinol or quinone). The reversible reduction of quinone is an essential feature of respiration, allowing the transfer of electrons between respiratory complexes.


Pssm-ID: 239602  Cd Length: 199  Bit Score: 123.87  E-value: 9.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  24 LDFIQSASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFLELKfiyndpmmSYITSFLAACVLVVFFVHALLAMRKFPIN 103
Cdd:cd03526    1 LDWLQSATGLFLGLFMIGHLFFNSTILLGDNVMNWVAKKFELL--------PIVVSFLAAFIFAVFIAHAFLGVRKFPIY 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 104 fRQYQILRTHAKKMnHGDTSLWLVQAFTGFVMFFLGSAHL-IFVI--TNGDKISADMSGDRVINHFMWLFYIALLICVEL 180
Cdd:cd03526   73 -RQALTFKTHKDLM-HGDTTLWWIQAMTGFAMLFFGSVHLyIMMTqaQPDRTIGFVMSSNRMSSEWMWPLYIVLLFAVEL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488866145 181 HGSIGLYRLCVKWGWFeakDVKDIRKSRKKLKMAKWIISIFFLVLGVLSLAA 232
Cdd:cd03526  151 HGSVGLYSFAVTWGWF---DGETPDKSRANLKKLKTLMSAFLSVLGLLTFGA 199
Sdh_cyt pfam01127
Succinate dehydrogenase/Fumarate reductase transmembrane subunit; This family includes a ...
 119-225 5.40e-10

Succinate dehydrogenase/Fumarate reductase transmembrane subunit; This family includes a transmembrane protein from both the Succinate dehydrogenase and Fumarate reductase complexes.


Pssm-ID: 426067  Cd Length: 122  Bit Score: 55.85  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  119 HGDTSLWLVQAFTGFVMFFLGSAHLIFVITNGDKISADMSGDRVINHF---MWLFYIALLICVEL-HGSIGLYRLCVKWG 194
Cdd:pfam01127  17 HLTTWLSILHRITGVALAVLGLIFLLLWLLLLLSLLGPESYATVVAWLaspVKLILLLLLLLALFyHAANGIRHLIWDVG 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 488866145  195 WFeakdvKDIRKSRKKLKMAKWIISIFFLVL 225
Cdd:pfam01127  97 FG-----LELKTVRKSGAAVLALSVVLVIVL 122
SQR_QFR_TM cd03493
Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, ...
 126-228 7.26e-06

Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR, also called succinate dehydrogenase or Complex II, is part of the citric acid cycle and the aerobic respiratory chain, while QFR is involved in anaerobic respiration with fumarate as the terminal electron acceptor. SQRs may reduce either high or low potential quinones while QFRs oxidize only low potential quinols. SQR and QFR share a common subunit arrangement, composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit(s) containing the electron donor/acceptor (quinol or quinone). The reversible reduction of quinone is an essential feature of respiration, allowing the transfer of electrons between respiratory complexes. SQRs and QFRs can be classified into five types (A-E) according to the number of their hydrophobic subunits and heme groups. This classification is consistent with the characteristics and phylogeny of the catalytic and iron-sulfur subunits. Type E proteins, e.g. non-classical archael SQRs, contain atypical transmembrane subunits and are not included in this hierarchy. The heme and quinone binding sites reside in the transmembrane subunits. Although succinate oxidation and fumarate reduction are carried out by separate enzymes in most organisms, some bifunctional enzymes that exhibit both SQR and QFR activities exist.


Pssm-ID: 239573  Cd Length: 98  Bit Score: 43.42  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 126 LVQAFTGFVMFFLGSAHLIFVITNGDKISA-DMSGDRVINHFMWLFYIALLICVELHGSIGLYRLCVKWGWFEAKdvkdi 204
Cdd:cd03493    1 ILHRITGVALLLFLPLHLLGLLALLGGPYAfAEVVAFLSSPLGKLLYLLLLLALLYHALNGIRHLIWDYGKGLEL----- 75

                         90       100
                 ....*....|....*....|....
gi 488866145 205 rKSRKKLKMAKWIISIFFLVLGVL 228
Cdd:cd03493   76 -KLRKALGYAVLALSVLLTVLLLF 98
SQR_TypeB_1_TM cd03497
Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of ...
 27-232 1.22e-04

Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis SQR reduces low potential quinones such as menaquinone. SQR is also called succinate dehydrogenase (Sdh) or Complex II and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside on the transmembrane subunit. The transmembrane subunit of Bacillus subtilis SQR is also called Sdh cytochrome b558 subunit. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron acceptor (quinone). The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.


Pssm-ID: 239577  Cd Length: 207  Bit Score: 41.92  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  27 IQSASGLF-LGLFMWVHMVFVSTILVSKDFFNSVVHFlelkfIYNDPMMSYITSFLAACVLVVFFVHALLAMRKFPINFR 105
Cdd:cd03497    9 LHSLLGVVpIGLFLIEHLLTNSSAASGPEGFNAAVNF-----MHSLPGLLLIEIFGIFLPLLFHAIYGIYIAFTAKSNTG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 106 QYQILRTHAkkmnhgdtslWLVQAFTGFVMFFLGSAHLI---FVITNG---------DKISADMSGDRVINHFMWLFYIA 173
Cdd:cd03497   84 RYDYFRNWM----------YTLQRITGIILLVFIAWHVWhtrFAEALGhvdiqtpeaGEANLSAMRNALASPLMLIFYII 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488866145 174 LLICVELHGSIGLYRLCVKWGwfeakdvkdIRKSRKKLKMAKWIISIFFLVLGVLSLAA 232
Cdd:cd03497  154 GVLAAVFHFANGLWTFLITWG---------ITVSPRSQRVSTYVCLLVFVVVSFMGVAA 203
SdhD COG2142
Succinate dehydrogenase, hydrophobic anchor subunit [Energy production and conversion];
125-234 2.74e-04

Succinate dehydrogenase, hydrophobic anchor subunit [Energy production and conversion];


Pssm-ID: 441745  Cd Length: 124  Bit Score: 39.81  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 125 WLVQAFTGFVMFFLGSAHLIFVITNGDkISADMSGDRVINHFMWLFYIALLICVELHGSIGL------YRLCVKWgwfea 198
Cdd:COG2142   23 WLLQRVTAVALVVLVLWFLFFLLSLPG-ADYAEVAAWFASPFWAILTLLFLLSALYHAWLGLrvviedYVHGTGL----- 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488866145 199 kdvkdirksRKKLKMAKWIISIFFLVLGVLSLAAFA 234
Cdd:COG2142   97 ---------RLALLLLLTLALVALAAAGVFALLRIA 123
SQR_TypeA_SdhD_like cd03500
Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like ...
 125-232 5.96e-03

Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential quinones such as menaquinone and thermoplasmaquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are similar to the Thermoplasma acidophilum SQR and are classified as Type A because they contain two transmembrane subunits as well as two heme groups. Although there are no structures available for this subfamily, the presence of two hemes has been proven spectroscopically for T. acidophilum. The two membrane anchor subunits are similar to the SdhD and SdhC subunits of bacterial SQRs, which contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.


Pssm-ID: 239580  Cd Length: 106  Bit Score: 35.71  E-value: 5.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145 125 WLVQAFTGFVMFFLGSAHL--IFVITNGDKISADMSGDRVINHFMWLFYIALLICVELHGSIGLYRLCVKWGwfeakdvk 202
Cdd:cd03500    5 WLFQRITGVFLVFLLAGHFwvQHMDNGGDVIDFAFVANRLASPLWKVWDLLLLVLALLHGGNGLRNILLDYV-------- 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 488866145 203 DIRKSRKKLKMAKWIISIFFLVLGVLSLAA 232
Cdd:cd03500   77 RRPRLRRAVKGLLYVAGLLLIVLGTYVIFA 106
sdhC_b558_fam TIGR02046
succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; This family ...
 29-195 6.50e-03

succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; This family consists of the succinate dehydrogenase subunit C of Bacillus subtilis, designated cytochrome b-558, and related sequences that include a fumarate reductase subunit C. This subfamily is only weakly similar to the main group of succinate dehydrogenase cytochrome b subunits described by pfam01127, so that some members score above the gathering threshold and some do not. [Energy metabolism, TCA cycle]


Pssm-ID: 131101 [Multi-domain]  Cd Length: 214  Bit Score: 37.07  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145   29 SASGLFLGLFMWVHMVFVSTILVSKDFFNSVVHFlelkfiyndpmMSYITSFLAACVLVVFFVHALLAMRKFPINFRQYQ 108
Cdd:TIGR02046  10 ALTGLVLLLFLVVHMVGNLFALFGAEAFNAAAHF-----------LRSLPFRLWLERIILFVPFILHAVYAVILSIRNKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866145  109 ILR--THAKKMNHGDTSLWLVQAFTGFVMFFLGSAHLI---FVITNGDKISADMSG----DRVINHF----MWLFYIALL 175
Cdd:TIGR02046  79 NARpyRYMHKGRPGVSWASRTMRVTGIIVLIFIGWHVLdftIGAQMGEIFHMGVARhdgyDMVVLTFsspiMLSIYIVAM 158

                         170       180
                  ....*....|....*....|
gi 488866145  176 ICVELHGSIGLYRLCVKWGW 195
Cdd:TIGR02046 159 LALGFHLSHGLWSAAQTLGL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH