|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
27-434 |
3.16e-164 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 468.74 E-value: 3.16e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 27 LVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAIg 106
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 107 ffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVM 186
Cdd:TIGR00893 80 -----GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 187 GAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEQGGGLISMDDsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLT 266
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQG---KGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 267 YFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKAPIIVGMLLSCSMVVCNYTDS 346
Cdd:TIGR00893 232 GFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 347 AWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAA 426
Cdd:TIGR00893 312 PYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIG 391
|
....*...
gi 489316433 427 ILSYLLLV 434
Cdd:TIGR00893 392 ALSYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-433 |
8.56e-112 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 333.38 E-value: 8.56e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLQGAIGFFsagtaiILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17319 81 FTALTGFATSL------TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 GWHSVFVVMGAAGILLAVIWLKTVyepkkhpkvnkaelayieqggglismddskskqeteskwpyikqlltnRMLIGVYI 257
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLAL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 258 AQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkgrsLTFARKAPIIVGMLLSCS 337
Cdd:cd17319 187 GYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 338 MVVCNY-TDSAWLVVVIMSLAFFGKGFGALG-WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17319 261 GLLLAYlTTSPVVAVILLSLAGFGIGAASPVfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAA 340
|
410
....*....|....*...
gi 489316433 416 LVFVGANAIAAILSYLLL 433
Cdd:cd17319 341 FLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-439 |
2.36e-75 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 240.16 E-value: 2.36e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 11 ADKKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIAL 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 91 SIFFWSFFTLLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLM 170
Cdd:COG2271 81 GLLLWGLATLLFGFA------TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 171 GWLTHSFGWHSVFVVMGAAGILLAVIwlktvyepkkhpkvnkaelayieqggglismddskskqeteskwpyikqlltnr 250
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 251 MLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKgrsltfaRKAPIIV 330
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 331 GMLLS-CSMVVCNYTDSAWLVVVIMSLA-FFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNA 408
Cdd:COG2271 254 GLLLAaLALLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
410 420 430
....*....|....*....|....*....|.
gi 489316433 409 TGsFNGALVFVGANAIAAILSYLLLVGPIKR 439
Cdd:COG2271 334 TG-YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
26-416 |
2.71e-65 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 214.55 E-value: 2.71e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 26 FLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLlqgai 105
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNL----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 106 gFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMG-WLTHSFGWHSVFV 184
Cdd:TIGR00881 76 -FFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 185 VMGAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEQgggliSMDDSKSKQETESKWP-YIKQLLTNRMLIGVYIAQYCIT 263
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-----PDGDAEKKEEELTKKQiFLQYVLLNKVLWYISLGYVFVY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 264 TLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLK-KGRSLTFARKAPIIVGMLLSCSMVVCN 342
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgRRGPLAVFFMALIIVSLLVYWLNPAAN 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489316433 343 YTdsaWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGAL 416
Cdd:TIGR00881 310 PL---MDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG-WAGAF 379
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
22-424 |
1.67e-53 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 183.14 E-value: 1.67e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLL 101
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 102 QGAIgffsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHS 181
Cdd:cd17380 81 TPLL----AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 182 VFVVMGAAGILLAVIWlktvyepkkhpkvnkaelayieqggglismddskskqeteskWPYIKQLLTnrmligVYIAQYC 261
Cdd:cd17380 157 VFYFFGLLGLLWALVW------------------------------------------LIYLPPVWA------IIVAHFC 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 262 ITTLTYFFLTWFPVYLVQARGmSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKAPIIVGMLLS--CSMV 339
Cdd:cd17380 189 MNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPalFLLL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 340 VCnYTDSAWLVVVIMSLAFFGKGFGALGWAV-VSDTSPKeCAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFngALVF 418
Cdd:cd17380 268 LS-HTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAPN-YAGIVFGISNTAGTIPGIVGVYLTGYILEATGSW--SLVF 343
|
....*.
gi 489316433 419 VGANAI 424
Cdd:cd17380 344 VLAAVV 349
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
23-406 |
2.81e-48 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 170.11 E-value: 2.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 23 FMLFLVTSINYADRATLSI-----TGDSVQHDLGLDSVAM-----------------GYVFSAFGWAYVIGQLPGGWLLD 80
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVaivamVNSTATHDNNNTSTDKdtlpveapefdwsektqGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 81 RFGSKTVIALSIFFWSFFTLLQGAigffSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY 160
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPL----AARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 161 FAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVyepkkhpkvnkaelayieqggglismddskskqeteskw 240
Cdd:cd17318 158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 241 pyikqlltnRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGR-S 319
Cdd:cd17318 199 ---------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 320 LTFARKAPIIVGMLLS--CSMVVCNYTDSAWLVVVIMSLAFFGKGFGALGWAV-VSDTSPKeCAGLSGGLFNTFGNIASI 396
Cdd:cd17318 270 TTTVRKLFTSIGFLGPgvFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVnHLDLAPN-YAGTLMGITNTAATIAGI 348
|
410
....*....|
gi 489316433 397 TTPIIIGYIV 406
Cdd:cd17318 349 ISPLIVGAIV 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-432 |
2.00e-47 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 167.75 E-value: 2.00e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 16 SVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFW 95
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 96 SFFTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTH 175
Cdd:COG2223 81 GIGLLL------LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 176 SFGWHSVFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAelayieqggglismddskskqeteSKWPYIKQLLTNRMLIGV 255
Cdd:COG2223 155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK------------------------ASLRDQLEALRDPRFWLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 256 YIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRSLTFArkapIIVGMLLS 335
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD---RIGGRRVLL----IVFALMAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 336 CSMVVCNYTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNG 414
Cdd:COG2223 284 GLLLLALALGSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA 363
|
410
....*....|....*....
gi 489316433 415 A-LVFVGANAIAAILSYLL 432
Cdd:COG2223 364 AfLVFAVLALVALVLTLLL 382
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-428 |
2.21e-38 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 143.15 E-value: 2.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALsiffwsfFTLLQGAIGFF-SAGTAIILLFALRFLVG 125
Cdd:cd17475 23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAV-------GLLLMGAAALLmALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 126 LSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPK 205
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 206 khpkvnkaelayieqggglismDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSI 285
Cdd:cd17475 176 ----------------------AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 286 LEAGFVASLPALCGFAGGVLGGIVSDILLKKGR--SLTFArkapIIVGMLLSCSMVVCNYTDSAWLVVVIMSLA-FFGKG 362
Cdd:cd17475 234 VAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRrpVLVIT----AAIAAAALLVLSLLSPGTPLWLLVLLLILLgLFAIG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489316433 363 FGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAIL 428
Cdd:cd17475 310 WNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-395 |
1.36e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 140.11 E-value: 1.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:COG2814 88 GSLL------CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 GWHSVFVVMGAAGILLAVIWLKTVYEPKKHPKvnkaelayieqggglismddskskqetESKWPYIKQLLTNRMLIGVYI 257
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAAR---------------------------ARLRGSLRELLRRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 258 AQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLSC- 336
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD---------RFGRRRLLLIGLLLLAl 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 337 SMVVCNYTDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIAS 395
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLlFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
15-449 |
1.62e-34 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 134.10 E-value: 1.62e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 15 TSVRWFIVFMLFLVTSINYADRATLSITG---------------------DSVQHDLGLDSVAM-GYVFSAFGWAYVIGQ 72
Cdd:TIGR00894 14 CSFRLFLSFLLHICNVIIIAQRICLSLTMvamvnkenstdlaclsaenelDNIKNPNFKWSGALqGLILSSHFYGQIIIQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 73 LPGGWLLDRFGSKTVIALSIFFWSFFTLLQgaigFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTAS 152
Cdd:TIGR00894 94 IPVGYLAGKYVFKWSIGIGMFLSSVISIVI----PWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 153 AFFNSAQYFAIVIFSPLMGWLTHSF-GWHSVFVVMGAAGILLAVIWLKTVYE-PKKHPKVNKAELAYIeqGGGLISMDDS 230
Cdd:TIGR00894 170 GMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADdPSIHPCISKFEKKYI--NSSLQGQKGS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 231 KSKqetesKWPyIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVS 310
Cdd:TIGR00894 248 TRQ-----SLP-IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 311 DILLKKGR-SLTFARKAPIIVGMLLSCSMVVCNY--TDSAWLVVVIMSLAffgKGFGALGWAVVSDTSPK---ECAGLSG 384
Cdd:TIGR00894 322 DFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPylSAAFYLTIIILTLA---NAVSSGPLAGVLINSLDlapRFLGFIK 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489316433 385 GLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAI-LSYLLLVGPIKRVVLKKQEQDP 449
Cdd:TIGR00894 399 GITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILcVIFYLIFGSAERQDWAKEEKDT 464
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-433 |
1.70e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 132.31 E-value: 1.70e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaigfFSAGTAIILLFALRFLVGLS 127
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL------FAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 128 EAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPKKH 207
Cdd:cd17325 98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 208 PKvnkaelayieqggglismddsKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILE 287
Cdd:cd17325 178 PN---------------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 288 AGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLSC-SMVVCNYTDSAWLVVVIMSLAFFGKGFGAL 366
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSD---------RIGRKPLILIGLLLSAvALLLLPLATSFWLLLLLLALLGLGLGLVFP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489316433 367 GW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17325 308 ATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-399 |
3.67e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 130.62 E-value: 3.67e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 25 LFLVTSINYADRATLSIT-GDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqg 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 104 aigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVF 183
Cdd:pfam07690 79 ----LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 184 VVMGAAGILLAVIWLKTVYEPKKHPKvnkaelayieqggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAqYCIT 263
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRP--------------------KPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 264 TLTYFFLTWFPVYlVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkapIIVGMLLSCSMVVCNY 343
Cdd:pfam07690 214 FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA-----LLLLILAALGLLLLSL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489316433 344 TDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTP 399
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-431 |
5.14e-34 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 131.01 E-value: 5.14e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 25 LFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqga 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 105 igfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLT--HSFGWHSV 182
Cdd:cd06174 78 ---FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 183 FVVMGAAGILLAVIWLKTVYEPKKHPKVNKAElayieqggglismddskskQETESKWPYIKQLLTNRMLIGVYIAQYCI 262
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESARAKNEE-------------------ASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 263 TTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrsLTFARKAPIIVGMLLS--CSMVV 340
Cdd:cd06174 216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD--------RLIGRKPLLLIGLLLMalGLALL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 341 CNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVG 420
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
410
....*....|.
gi 489316433 421 ANAIAAILSYL 431
Cdd:cd06174 368 VLLLLAAILLL 378
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-415 |
1.23e-32 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 127.74 E-value: 1.23e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLL 101
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 102 QGAIGFFsagtaiILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFnsaqYFAIVIFS----PLMGWLTHSF 177
Cdd:cd17328 81 SSFAPNF------WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVF----YFAIPLGSglgyVVGGLVAQAT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 -GWHSVFVVMGAAGILLAVIWLKTVYEPKKHPkvnkaelayIEQGGGLISmddskskqETESKWPYIKQLLTNRMLIGVY 256
Cdd:cd17328 151 gGWRWAFRVTGVLGVLLAILLLLFVREPPRGA---------AEGGVMAKS--------TATSFLADLKALAKNPSFILST 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 257 IAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVA----SLPALCGFAGGVLGGIVSDILLKKGRSlTFARKAPIIVGM 332
Cdd:cd17328 214 LGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRKTPR-ADPLVCAVGLLA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 333 LLSCSMVVCNYTDSAWLVVVIMslAFFGKGFGALGWAVVSD----TSPKECAGLSGGLFNTFGN-IASITTPIIIGYIVN 407
Cdd:cd17328 293 AAPFLFLALVLALSNLLLAWVL--LFLGEFLLSLNWAPVFAillyVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLISD 370
|
....*...
gi 489316433 408 ATGSFNGA 415
Cdd:cd17328 371 LLRQNKDS 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-428 |
2.07e-30 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 120.84 E-value: 2.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLlqgaigFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17312 81 ANI------FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 GWHSVFVVMGAAGILLAVIWLKTVYEpkkHPkvnkaelayieqggglismddskskqeteskwPYIKQLLTNRMLigVYI 257
Cdd:cd17312 155 GWRAAFLVPGIVGLVVAIILFFFLRD---SP--------------------------------PYVWVLSLAYAF--VYI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 258 AQYCittltyfFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRsltfaRKAPIIVGMLLSCS 337
Cdd:cd17312 198 VRYA-------CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRR-----APIAVIYMLLMTLS 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 338 MVVCN-YTDSAWLVVVIMSLA-FFGKGFGALGWAVVS-DTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNG 414
Cdd:cd17312 266 LALFWfFPHNKLLSIVLLFLIgFFVGGPINLIGGAAAqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTV 345
|
410
....*....|....
gi 489316433 415 ALVFVGANAIAAIL 428
Cdd:cd17312 346 FYFLISAALLSVLL 359
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
23-433 |
6.02e-27 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 111.95 E-value: 6.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 23 FMLFLVTSINYAD----RATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFF 98
Cdd:cd17345 2 WQVFLGIFIGYAGyylvRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 TLLQGAIGffSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG 178
Cdd:cd17345 82 NILIGFVP--SATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 179 ---WHSVFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEQGGGLISMDDSKSKQETESKWPYIkqlLTNRMLIGV 255
Cdd:cd17345 160 dgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYV---LKNKLLWYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 256 YIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTfarkaPIIVGMLLS 335
Cdd:cd17345 237 AIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPT-----GIIFMILVI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 336 CSMVVCNYTDSAWLVVVIMSLA-FFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNI-ASITTPIIIGYIVNATGSFN 413
Cdd:cd17345 312 VALIVYWLAPNVLVDLIALIALgFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNG 391
|
410 420
....*....|....*....|
gi 489316433 414 GALVFVGANAIAAILSYLLL 433
Cdd:cd17345 392 GFIVLLASCILAIIFLALVA 411
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
53-405 |
8.14e-27 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 111.41 E-value: 8.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 53 DSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAIGFFSAGtaiiLLFALRFLVGLSEAPSF 132
Cdd:cd17381 63 DAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAG----YLIAVRALEGLGEGVTF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 133 PGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEpkkhpkvnk 212
Cdd:cd17381 139 PAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMP--------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 213 aelayieqggglismddskskqeteskwpyikqlltnrmLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVA 292
Cdd:cd17381 210 ---------------------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 293 SLPALCGFAGGVLGGIVSDILLKKGR-SLTFARKAPIIVGM------LLSCSMVVCNYTdsawLVVVIMSLAFFGKGFGA 365
Cdd:cd17381 251 ALPYLGCWLFMILSGQIADNLREKQNfSTVCVRKIFTLIGMigpavfLLAAGFTGCNYS----LAVAFLTISSTLGGFSA 326
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 489316433 366 LGWAVVS-DTSPKEcAGLSGGLFNTFGNIASITTPIIIGYI 405
Cdd:cd17381 327 SGFNINHlDIAPSY-AGILLGITNTFATIPGMVGPVIAKSL 366
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-433 |
1.10e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 105.34 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 9 SPADKKTSVRWFIVFMLFLVtSINYadRATLSITG---DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSK 85
Cdd:COG2807 7 SARRSRRAGRWLLLLAIVLV-ALNL--RPAITSVGpllPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 86 TVIALSIFfwsfftLLQGAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVI 165
Cdd:COG2807 84 RTLLLALL------LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 166 FSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELAyieqggglismddskskqeteskwpyIKQ 245
Cdd:COG2807 157 AAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS--------------------------LRS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 246 LLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLvQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARK 325
Cdd:COG2807 211 LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD---------RLGDR 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 326 APIIVGMLLS--CSMVVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSD--TSPKECAGLSgGLFNTFGNIASITTPII 401
Cdd:COG2807 281 RPLLLLLGLLglAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLraRTPAEAAALS-GMAQSVGYLLAALGPLL 359
|
410 420 430
....*....|....*....|....*....|..
gi 489316433 402 IGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:COG2807 360 VGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-431 |
1.43e-22 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 98.44 E-value: 1.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 22 VFMLFLVTSINYADRATLSITGDSVQH--DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFT 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 100 LLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF-- 177
Cdd:cd17316 81 LLIGLL------PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsg 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 --GWHSVFVVMGAAGILLAVIWLKTVyepkkhpkvnkaelayieqggglismddskskqeteskwpyikqlltnrMLIGV 255
Cdd:cd17316 155 dwGWRILFLIGALPALLALLLRRRTL-------------------------------------------------LLILL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 256 YIaqyCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkGRSLTFArkAPIIVGMLLS 335
Cdd:cd17316 186 WF---FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLV--IGLILSGILA 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 336 CSMVVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17316 258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVP 337
|
410
....*....|....*.
gi 489316433 416 LVFVGANAIAAILSYL 431
Cdd:cd17316 338 ALILALLAIVALIVAL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
47-433 |
2.51e-21 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 94.95 E-value: 2.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFtllqGAIGFFSagTAIILLFALRFLVGL 126
Cdd:cd17473 27 QHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG----GVAGLFL--DSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLThSFGWHSVFVVMGAAGILLAVIWLKtVYEPKK 206
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLF-LPEPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 207 HpkvnkaelayieqggglismddsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSIL 286
Cdd:cd17473 179 K-------------------------SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 287 EAGFVASLPALCGFAGGVLGGIVSDILLKkgrsltfaRKAPIIVGMLLSCSMVVCNYTDSAWlvVVIMSLAFFGKGFGAL 366
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGRLKRRLGK--------RRLLAIGFALMALGFLLLALASGLW--VVLLGAILAGLGFGLL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 367 GWAV---VSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17473 304 LPTLnswAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-406 |
4.38e-20 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 91.65 E-value: 4.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 4 DYANVSPADKKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFG 83
Cdd:TIGR00895 1 DVQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 84 SKTVIALSIFFWSFFTLLQGAigffsaGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAI 163
Cdd:TIGR00895 81 RRRVLLWSILLFSVFTLLCAL------ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 164 VIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEP------KKHPKVNKAELAYIEQGGGLISMDDSKSKQETE 237
Cdd:TIGR00895 155 AVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESidflvsKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 238 SKWPYIKQLLTNRMLIGVYI--AQYCITTLTYFFLT-WFPVYLVQArGMSILEAGFVASLPALCGFAGGVLGGIVSDILl 314
Cdd:TIGR00895 235 TKRSVFKALFQGKTARITVLlwLLYFMLLVGVYFLTnWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRL- 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 315 kkGRSLTFArkAPIIVGMLLscSMVVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIA 394
Cdd:TIGR00895 313 --GPRVTAL--LLLLGAVFA--VLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLG 386
|
410
....*....|..
gi 489316433 395 SITTPIIIGYIV 406
Cdd:TIGR00895 387 AIIGPILAGYLL 398
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
18-433 |
2.00e-19 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 89.70 E-value: 2.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17343 81 TTVA------FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 GWHSVFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELAYieqgggliSMDDSKSKQETESKWpyiKQLLTNRMLIGV-- 255
Cdd:cd17343 155 GWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEE--------SKGKKKKSPRGESTL---KELLLSPFLWLLsl 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 256 -YIAQYCITTLTyffLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKK--GRSLTFARKAPIIVGM 332
Cdd:cd17343 224 gYLVVFGVKTAV---TDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKhgSSSRGNPRMPLALVFM 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 333 L-LSCSM-----VVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIV 406
Cdd:cd17343 301 AgLTVSLhlfrvHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIA 380
|
410 420
....*....|....*....|....*..
gi 489316433 407 NATGsFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17343 381 KHYD-WRTAFLLLEILCAITVVILFLL 406
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
44-429 |
2.91e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 2.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 44 DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAigffsaGTAIILLFALRFL 123
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL------APSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 124 VGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYE 203
Cdd:cd17324 97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 204 PKKHPKVNKAELAyieqggglismddskskqeteskwpYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGM 283
Cdd:cd17324 177 LPPKKPGSLGLLS-------------------------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 284 SILEAGFVASLPALCGFAGGVLGGIVSDILLKKgrsltfarkaPIIVGMLLSCSMVVCNYTDSAWLVVVIMSLAFFGKGF 363
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR----------ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489316433 364 GALG---WAVVSDTSPkECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILS 429
Cdd:cd17324 302 FAAHsalQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-432 |
6.46e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 87.99 E-value: 6.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 11 ADKKTSVRWFIVFMLFLVTSINYAdraTLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIAL 90
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 91 SIFFWSFftllqGAIGFFSAGTAIILLFALrFLVGLseapsfpGNGRVVASWFPSS---ERGTASAFFNSAQYF---AIV 164
Cdd:COG0738 79 GLLLMAL-----GLLLFALAPSYPLLLLAL-FLLGL-------GLGLLDVAANPYVaalGPETAASRLNLLHAFfslGAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 165 IFSPLMGWLTH---SFGWHSVFVVMGAAGILLAVIWLKTVYEpkkhpkvnkaelayieqggglismDDSKSKQETESKWP 241
Cdd:COG0738 146 LGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKLP------------------------EIEEEEEEAAGSAA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 242 YIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrslt 321
Cdd:COG0738 202 SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR--------- 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 322 FARKAPIIVGMLLSC-SMVVCNYTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTP 399
Cdd:COG0738 273 FGPVRLLRLSALLAAvGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGP 351
|
410 420 430
....*....|....*....|....*....|...
gi 489316433 400 IIIGYIVNATGSFNGALVFVGANAIAAILSYLL 432
Cdd:COG0738 352 PLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
19-401 |
6.48e-19 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 88.46 E-value: 6.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTSINYADRATLS---ITGdsVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFW 95
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISnaaVMG--MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 96 SFFTLLQGAIGFFSAgtaiilLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIvIFSPLMGW--- 172
Cdd:cd17327 82 GLLTLLTAAVKNFGG------LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGS-IFGGLLAYgvf 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 173 ---LTHSF-GWHSVFVVMGAAGILLAVI---WLKTVyePKKHPKVNKAELAYIeqgggLISMD-DSKSKQETESKWPYIK 244
Cdd:cd17327 155 kilGVGGLaGWRWLFIIEGLITIIIGLViffWLPDN--PSKAWFLTEEEKELA-----VERLRaNQTGKGDQKFKWKQIK 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 245 QLLTNRMLIGVYIAQYCITTLTYFFLTWFPVyLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFAr 324
Cdd:cd17327 228 EAFKDPRTWLLFLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFA- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 325 KAPIIVGmllSCSMVVCNYTDSAWLVVVIMSLAFFGKGFGALGWAvvSDTspkeCAGLSG-----GLFNTFGNIASITTP 399
Cdd:cd17327 306 CVLALVG---SIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWI--SSN----CAGYTKratvlAIMLIFYNVGNIVAP 376
|
..
gi 489316433 400 II 401
Cdd:cd17327 377 QI 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-199 |
6.01e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 84.09 E-value: 6.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 9 SPADKKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVI 88
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 89 ALSIFFWSFFTLLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSP 168
Cdd:COG0477 83 LIGLLLFGLASLLCGLA------PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
|
170 180 190
....*....|....*....|....*....|.
gi 489316433 169 LMGWLTHSFGWHSVFVVMGAAGILLAVIWLK 199
Cdd:COG0477 157 LGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
22-431 |
4.33e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 82.61 E-value: 4.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 22 VFMLFLVTSInyadratLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFwsfFTLL 101
Cdd:cd17321 5 VFLAALDVTI-------VNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLAL---FGLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 102 QGAIGFfsAGTAIILLFAlRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHS 181
Cdd:cd17321 75 SLLCAL--APSLAFLIAA-RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 182 VFVVMGAAGILLaviwlktvyepkkhpkvnkaelayieqggglismddskskqeteskwpyikqLLTNRMLIGVYIAQYC 261
Cdd:cd17321 152 IFLINVPIGLVA----------------------------------------------------LLLARTFSGAVLAAFL 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 262 ITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLSC----S 337
Cdd:cd17321 180 LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD---------RFGPRLVLVAGLLLTAvgllL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 338 MVVCNYTDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGAL 416
Cdd:cd17321 251 LALLGADSSVWLLLPGLVLLGLGLGLfATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGD 330
|
410
....*....|....*
gi 489316433 417 VFVGANAIAAILSYL 431
Cdd:cd17321 331 SGVAALLSAAAAAFA 345
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
18-431 |
9.16e-17 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 81.90 E-value: 9.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSiffwSF 97
Cdd:cd17398 2 RWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLG----SF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLQGAIGFFSAGTAII-LLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASA---FFN---SAQYFAIVIFSPLM 170
Cdd:cd17398 78 LNCLGAWLKLFSSSPDLFwVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAigvFGNqlgVALGFVLPPLLVPN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 171 GWLTHSFGWHSVFVVMGAAGI-----LLAVIWLKTvyEPKKHPkvNKAELAYIEQggglismddsksKQETESKWPYIKQ 245
Cdd:cd17398 158 SENKDEIGKGLSILFYGVAGIctalfILVIIFFKE--KPPIPP--SRAQAAAQEL------------RSEDQSYLGSLKR 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 246 LLTNRMLI------GVYIAQYCI--TTLTYFFLTWFPVYLVQArgmsileaGFVASLPALCGFAGGVLGGIVSDillkkg 317
Cdd:cd17398 222 LFKNKGFLlllityGINTGVYYAisTLLNQMVLEYFPNEEVNA--------GWIGLTLVIAGLVGSVVAGIWLD------ 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 318 RSLTFaRKAPIIVGMLLSCSMVVCNYT---DSAWLVVVIMS-LAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNI 393
Cdd:cd17398 288 KTKKY-KETTIIVYILSFIGMVAFTFTldlGSIWVVFLTAGaLGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQI 366
|
410 420 430
....*....|....*....|....*....|....*...
gi 489316433 394 ASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYL 431
Cdd:cd17398 367 FGIIFTLVMGALLDKVGALASNIVLSVALLLGTILTAF 404
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
58-424 |
1.45e-16 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 80.85 E-value: 1.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGR 137
Cdd:cd17382 52 GLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIP----IAARVHYGCVIFVRILQGLVEGVTYPACHG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 138 VVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLktvyepkkhpkvnkaelay 217
Cdd:cd17382 128 IWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWM------------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 218 ieqgggLISMddskskqeteSKWPYIkqlltnrmligvyIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPAL 297
Cdd:cd17382 189 ------LVSM----------PVYAII-------------VANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 298 CGFAGGVLGGIVSDILLKKGR-SLTFARKAPIIVGMLLSCSMVVC-NYTDSAWLVVVIMSLAFFGKGFGALGWAVVS-DT 374
Cdd:cd17382 240 VMTIIVPIGGQLADYLRSRGIlSTTAVRKIFNCGGFGMEATFLLVvAFSHSPTVAISFLVLAVGFSGFAISGFNVNHlDI 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489316433 375 SPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAI 424
Cdd:cd17382 320 APRY-ASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLV 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
49-433 |
5.35e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 79.27 E-value: 5.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaIGFfsaGTAIILLFALRFLVGLSE 128
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL---CGF---AQNYWQLLILRALAGLGF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 129 APSFPGNGRVVASWFPSSERGTASAFFNSAQY----FAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIwlktvyep 204
Cdd:cd17371 102 GGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFI-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 205 kkHPKVNKAELAYIEQGGGliSMDDSKSKQETESKWPYIK-QLLTNRMLIGVYIAQYCITTltyffltWFPVYLVQARGM 283
Cdd:cd17371 174 --RRFVKEPPQWQAARAAR--RHFADRPSLRELFSPPLLRtTLLASLLATGALGGYYGITT-------WLPSYLTGERGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 284 SILEAGFVASLPALCGFAGGVLGGIVSDILlkkGRSLTFArkapiiVGMLLSCSMVVC--NYTDSAWLVVVIMS-LAFFG 360
Cdd:cd17371 243 SFEGSAGYLVVTILGGFLGYLAGGFLADRI---GRRNNFA------LFALGSAISILLyfFLPLSPTLILILGFpLGFFA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489316433 361 KG-FGALGwAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17371 314 SGpFSGMG-AYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
19-428 |
1.21e-15 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 78.06 E-value: 1.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTSInyadratLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFF 98
Cdd:cd17341 5 WLSFFLGFMVWFL-------FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 TLlqgaiGFFSAGTAIILLFALRFLVGLSEApSFPGNGRVVASWFPSSERGTASA-------FFNSAQYFAIVIFSPLMG 171
Cdd:cd17341 78 LL-----ALALAVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGgiagagnMGVAVSQLLAPLIAGAIV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 172 WLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEQGgglismddSKSKQETESKWPYIkqlltnrM 251
Cdd:cd17341 152 FDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAV--------LKNYRTWILSLLYG-------V 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 252 LIGVYIAqycittltyfFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkKGRSLTFARKAPIIVG 331
Cdd:cd17341 217 TFGSFVG----------FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF--GGRRRLWWLFIVMTIG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 332 MLLsCSMVVCNYTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATG 410
Cdd:cd17341 285 AAL-LSLSLPTSGTNLVLFLALFVALGLGAGAGnGSVFRMVPFIFRRE-LGAVTGLVGAIGGLGGFFLPLLFGSSALMTG 362
|
410
....*....|....*...
gi 489316433 411 SFNGALVFVGANAIAAIL 428
Cdd:cd17341 363 SGVGAFSLFGVLAVACTL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-434 |
3.94e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.48 E-value: 3.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 20 FIVFMLFLVTSINYAdratlsitgdsvqHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFwsfFT 99
Cdd:cd17489 9 FLSFYLLLPVLPLYA-------------HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLI---FA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 100 LLQGAIGFfsaGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGW 179
Cdd:cd17489 73 LATLLYLL---ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 180 HSVFVV-MGAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEqgggLISMddskskqeteskwpyiKQLLTNRMLIGVYIA 258
Cdd:cd17489 150 AVLFIVaAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRR----LVEK----------------KVLPPALILFLASIA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 259 QYCITTLTyffltwfPVYlVQARGMSilEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLL-SCS 337
Cdd:cd17489 210 YGAISTFL-------PLY-AAERGIS--NAGLFFTVYAIALLLSRPFSGKLSD---------RKGPKTVIIPGLLLlALG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 338 MVVCNYTDSAWLVVVimSLAFFGKGFGAL---GWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNG 414
Cdd:cd17489 271 LLLLSFAGSPWMLLL--AAVLYGLGFGLLfpaLQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRA 347
|
410 420
....*....|....*....|
gi 489316433 415 ALVFVGANAIAAILSYLLLV 434
Cdd:cd17489 348 MFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
50-430 |
5.34e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.06 E-value: 5.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAIGFFSagtaiiLLFALRFLVGLSEA 129
Cdd:cd17478 26 LGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW------LLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 130 pSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKtVYEPKKHPK 209
Cdd:cd17478 100 -AFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR-LRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 210 VNKAelayieqggglismddsKSKQETESKWPYIKQLLtnrMLIGVYIAQYCIttlTYFFLTWFPVYLVQaRGMSILEAG 289
Cdd:cd17478 178 KKAA-----------------AKSSARSTLKGVWRALL---LLLIIVFLRSWV---LSSLTTFLPFYLVQ-RGYSLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 290 FVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLSC-SMVVCNYTDSAWLVVVIMSLAFFGKGFGALGW 368
Cdd:cd17478 234 LLLSLFLFAGAIGTLIGGPLSD---------RFGRRRVIIASLLLAApFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489316433 369 AVVSDTSPkECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSY 430
Cdd:cd17478 305 VLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-433 |
6.89e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.68 E-value: 6.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 45 SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFtllqGAIGFFSAGTAIILLFalRFLV 124
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG----GLLCGLSDSFALLLAG--RALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 125 GLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIfSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEP 204
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 205 KKHPKVNKAELAYIEqggglismddskskqeteskwpyiKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMS 284
Cdd:cd17474 177 KEKAKSSSATKLRDL------------------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 285 ILEAGFVASLPAlcgfaggvLGGIVSDILLKKGRSLTFARKAPIIVGMLLSC-SMVVCNYTDSAWLVVVImsLAFFGKGF 363
Cdd:cd17474 233 PIIIGLLFAGWS--------VLLALGSLFVGRLLKKRFGARRILVIGLLLYAlSLLLLGFVPSLALLLIA--IVLFGLGL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489316433 364 G---ALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVnatGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17474 303 GlnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
57-447 |
7.13e-15 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 76.29 E-value: 7.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKtvialsiFFWSFFTLLQGAIGFFS-----AGTAIILLFALRFLVGLSEAPS 131
Cdd:PRK11273 65 LGFALSGISIAYGFSKFIMGSVSDRSNPR-------VFLPAGLILAAAVMLFMgfvpwATSSIAVMFVLLFLCGWFQGMG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 132 FPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPL----MGWLTHsfgWHSVFVVMGAAGILLAVIWLKTVYEPKKH 207
Cdd:PRK11273 138 WPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfllgMAWFND---WHAALYMPAFAAILVALFAFAMMRDTPQS 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 208 ---PKVNKAELAYIEQGgglismdDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMS 284
Cdd:PRK11273 215 cglPPIEEYKNDYPDDY-------NEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 285 ILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkapiIVGMLLSCSMVVCNYTDSAWLVVVIMsLAFFGKGFG 364
Cdd:PRK11273 288 LDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATG------VFFMTLVTIATIVYWLNPAGNPTVDM-ACMIVIGFL 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 365 ALGWAVVS-----DTSPKECAGLSGGLFNTFGNI-ASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIK 438
Cdd:PRK11273 361 IYGPVMLIglhalELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 440
|
....*....
gi 489316433 439 RVVLKKQEQ 447
Cdd:PRK11273 441 HHEELLQKR 449
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
19-431 |
7.63e-15 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 75.82 E-value: 7.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTsinyadrATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFf 98
Cdd:cd17333 2 YISFFSNGLTD-------ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISL- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 tllqGAIGFFsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTAS---AFFNSAQYFAIVIFSPLmgwLTH 175
Cdd:cd17333 74 ----ALALIF-ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNvlhGFFGLGALIGPLIATSL---LTS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 176 SFGWHSVFVVMGAAGILLAVIWLKTVYEPKKHpkvnkaelayieqggglismdDSKSKQETESKWPYIKQLLTNRMLIGV 255
Cdd:cd17333 146 ELSWSWAYLIIGLIYLLLAILILLTLFPELPS---------------------ARNPQQSVGAFSASASRLLRNPSIILG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 256 YIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkKGRSLTFArkapIIVGMLLS 335
Cdd:cd17333 205 ALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI--KPHTLLVL----SGSGALLG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 336 CSMVVCNYTdSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17333 279 LLILLLAPT-LVVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAM 356
|
410
....*....|....*.
gi 489316433 416 LVFVGANAIAAILSYL 431
Cdd:cd17333 357 LLITILYAIIFVLALL 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
50-437 |
3.71e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.17 E-value: 3.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKT-----VIALSIFFWSFFTLLQGAIGFFSAGTAIILLFALRFLV 124
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 125 GLSEAPSFPGNGRVVASWFPSS-ERGTASAFFNSAQYFAIVIFSPLMGWLTHSF------GWHSVFVVMGAAGILLAVIW 197
Cdd:COG2211 121 GLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 198 LKTVYEPKKHPKvnkaelayieqggglismddskskqETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYL 277
Cdd:COG2211 201 FFGTKERPVPEE-------------------------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 278 VQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKAPIIVGMLLSCSMVVCNY---TDSAWLVVVIM 354
Cdd:COG2211 256 KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FGKKKAFIIGLLLAALGLLLLFflgPGNLWLLLVLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 355 SLAFFGKG-FGALGWAVVSDTSP-------KECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALvfVGANAIAA 426
Cdd:COG2211 327 ALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA--QSPSALTG 404
|
410
....*....|.
gi 489316433 427 ILSYLLLVGPI 437
Cdd:COG2211 405 IRLLFFLLPAV 415
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-433 |
4.56e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.00 E-value: 4.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLL 101
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 102 QGaigffsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHS 181
Cdd:cd17365 81 TA------FAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 182 VFVVMGAAGILLAVIWLKTVyepkkhpkvnkaelayieqggglismddskskqeteskwpyikqlltnrMLIGVYIaqyC 261
Cdd:cd17365 155 VFLLGGVPPLILLPLLRGTL-------------------------------------------------LLWVTFF---M 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 262 ITTLTYFFLTWFPvYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrsltfaRKAPIIVGMLLSCSMVVC 341
Cdd:cd17365 183 GLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD------------RFGPKRVLALFFALGAVS 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 342 ------NYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17365 250 lallgvSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESV 329
|
410
....*....|....*...
gi 489316433 416 LVFVGANAIAAILSYLLL 433
Cdd:cd17365 330 FLALAIPAALGALAVLLL 347
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-431 |
5.66e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.99 E-value: 5.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIffwSFF 98
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGL---LLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 TLLQGAIGFFSAGTAIILLFALrfLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG 178
Cdd:cd17355 79 AAGLVLLALATSLWQLYLLWGL--LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 179 WHSVFVVMGAAGILLAVI-WLKTVYEPKKHPKVNKAELAYIEQGGGLismddskskqeteskwpyiKQLLTNRMLIGVYI 257
Cdd:cd17355 157 WRTALLVLALLALLVLVPvLLLLRRRPADLALRAYDDASPASPGSTL-------------------KEALRSASFWLLAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 258 AQYCITTLTYFFLTWFPVYLVQaRGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrsLTFARKAPIIVGMLLSCS 337
Cdd:cd17355 218 AFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGD--------RYSPRRLLAASYALRALG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 338 MVVCNYTDSA--WLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17355 289 LALLLLLPFPplALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAA 368
|
410
....*....|....*.
gi 489316433 416 LVFVGANAIAAILSYL 431
Cdd:cd17355 369 WALAVALGLIAALLVL 384
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
38-432 |
2.29e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.94 E-value: 2.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 38 TLSITGDSVQH--------DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSiFFWSFFTLLQGAIGFFS 109
Cdd:cd06173 9 LLSALGDWIFTvalpwlvlQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILA-DLLRALLAAVLALLALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 110 AGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVmGAA 189
Cdd:cd06173 88 GSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI-NAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 190 GILLAVIWLKTVYEPKKHPKVNKAELAYIEQGGGLIsmddskskqeteskwpYIKQLLTNRMLIGVYIAQYCITTLTYFF 269
Cdd:cd06173 167 SFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLR----------------YLRRSPLLRLLLLALALFALLGGALTVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 270 LtwfPVYLVQARGMSILEAGFVASLPALcgfaGGVLGGIVSDILLKKGRSLTFArkapIIVGMLLSCSMVVCNYTDSAWL 349
Cdd:cd06173 231 L---PLLAKEVLGGGAAGYGLLLAAFGV----GALLGALLLGRLSKRRRRGRLL----LIGALLLGLALLVLGLSPSLWL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 350 VVVIMSLAFFGKGFGALGW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAIL 428
Cdd:cd06173 300 LLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
....
gi 489316433 429 SYLL 432
Cdd:cd06173 380 LLLL 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-434 |
1.09e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.98 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWsfftllqgAIGFFSAGTA--IILLFALRFL 123
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLF--------ILASLLCALAssIEQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 124 VGLSEAPsfpgnGRVVA-----SWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWL 198
Cdd:cd17320 97 QGLGAAA-----GSVVAraivrDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 199 KtvYEPKKHPKvnkaelayieqggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLV 278
Cdd:cd17320 172 L--FLPETLPE--------------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 279 QARGMSILEAGFVASLPALcgfaGGVLGGIVSDILLKKGRSLTFARKApIIVGMLLSCSMVVCNYT--DSAWLVVVIMSL 356
Cdd:cd17320 230 EQLGLSPAQFGLLFALNAI----ALILGSLLNGRLVRRFGPRRLLRLG-LLLLLAAALVLLLAALLggLSLWPLVAPLFL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 357 AFFGKGF---GALGWAVVSDtspKECAGLSGGLFNTFGNIASITTPIIIGYIVNatgsfNGALVFVGANAIAAILSYLLL 433
Cdd:cd17320 305 IFFGFGLifpNATSLALEPF---PHVAGTASALLGFLQFLIGALAGALVGLLPN-----GTALPMGLLILVLGLLALLLL 376
|
.
gi 489316433 434 V 434
Cdd:cd17320 377 I 377
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
48-436 |
2.14e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 62.29 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWsfftllqgaiGFFSAGTAII----LLFALRFL 123
Cdd:PRK11551 43 QEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALF----------GLFSLATAQAwdfpSLLVARLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 124 VGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGIL---LAVIWLK- 199
Cdd:PRK11551 113 TGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLlvpLLMRWLPe 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 200 -TVYEPKKHPKVNKAELAYIEQGGGlismddskskqeteskwpyikqllTNRMLIGVYIAQYCITTLTYFFLTWFPVYLV 278
Cdd:PRK11551 193 sRAFAQAAGAGKQRAPVLRALFGEG------------------------RATATLLLWISYFFTLIVLYFLLNWLPSLLV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 279 qARGMSILEAGFVASLPALCGFAGGVLGGIVSDiLLKKGRSLTFarkapIIVGMLLSCSMVvcnytdSAWLVVVIMSLAF 358
Cdd:PRK11551 249 -GQGLSRSQAGLVQIAFNIGGALGSLLIGALMD-RLRPRRVVLL-----IYAGILASLAAL------AAAPSFAGMLLAG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 359 FGKGFGALG-----WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSfngALVFVGAN----AIAAILS 429
Cdd:PRK11551 316 FAAGLFVVGgqsvlYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRS---TVGVIGASipviLVAALAA 392
|
....*..
gi 489316433 430 YLLLVGP 436
Cdd:PRK11551 393 LLLVSRP 399
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
47-425 |
4.97e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 61.05 E-value: 4.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAigffsAGTAIILLFAlRFLVGL 126
Cdd:cd17503 23 MGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL-----APNLASLIIF-RILQGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIwlktvyepkk 206
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL---------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 207 hpkvnkaelayieqgGGLISMDdskskqeteskwpyikqLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSIL 286
Cdd:cd17503 167 ---------------APLLDLR-----------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 287 EAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLSC--SMVVCNYTDSAWLVVVIMSLAFFGKGFG 364
Cdd:cd17503 215 ESGLVLAPGGLASAILSPLVGRLLD---------KFGPRLLLLAGLLLLAlgTLLLAFLTPDTSLWLIILPLFIRGLGMG 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489316433 365 AL-----GWAVVSdtSPKECAGLSGGLFNTFGNIA-SITTPIIIGYIVNATGSFNGALVFVGANAIA 425
Cdd:cd17503 286 LVfmplnTLALNS--LPPEQIGDATALFNTIRQLGgSIGTALLATLLTNRTQFHHSRLSELLAQQVQ 350
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
18-433 |
5.29e-10 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 60.88 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17488 81 INIL------FGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 GWHSVFVVMGAAGILLAvIWLktVYEPKKHPkvnkaelayieqggglismddskskqeteskwPYIKQLLTNRMLigVYI 257
Cdd:cd17488 155 GWRAGMYVPGIIAILMG-IVL--CWRLRDRP--------------------------------PYIWLLAFCYVL--VYV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 258 AQYCITtltyfflTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGR---SLTFArkapiiVGMLL 334
Cdd:cd17488 198 VRTAIN-------DWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRgpmNLIFA------LGLLV 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 335 SCSMVVCNYTDSAWLVVVIM-SLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFN 413
Cdd:cd17488 265 SVGALWLVPVHSYWLLATCFfTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWG-WS 343
|
410 420
....*....|....*....|
gi 489316433 414 GALVFVGANAIAAILSYLLL 433
Cdd:cd17488 344 GFFIVISIAAAISGLLLLPL 363
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
18-432 |
2.41e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 58.78 E-value: 2.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWsf 97
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 ftllqgAIGFFSAGTAI---ILLFALRFLVGLSEAPSFPGNGRVVASWFPSsERGTASAFFNSAQYFAIVIFSPLMGWLT 174
Cdd:cd17353 79 ------GLGFILSAFAIslpLLFLGYGVLGGIGAGIGYITPVSTAVKWFPD-KRGLATGIVIAGFGLGSLIFSPLIAYLI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 175 HSFGWHSVFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELAyieqggglismddsKSKQETESKWPYIKQLLTNRMLIG 254
Cdd:cd17353 152 NTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPL--------------ANNAENSPRDYTPREMLRTPTFWL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 255 VYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRSLTFarkapIIVGMLL 334
Cdd:cd17353 218 LWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSD---KIGRKNTL-----SIAFLIQ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 335 SCSMVVCNYT-DSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNaTGSF 412
Cdd:cd17353 290 GVAMFLLPFIgSVAVLFVLGVALIGFCYGGGfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY-TGGY 368
|
410 420
....*....|....*....|.
gi 489316433 413 NGALVFVGA-NAIAAILSYLL 432
Cdd:cd17353 369 NAAFIIAAAlSLVALALALLL 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-196 |
2.66e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.38 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 17 VRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWS 96
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 97 FFTLLQGAIGFFSAGTAIILLFALRFLVGLSEAPSfpgnGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17316 255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAL----YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170 180
....*....|....*....|
gi 489316433 177 FGWHSVFVVMGAAGILLAVI 196
Cdd:cd17316 331 TGGTGVPALILALLAIVALI 350
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-200 |
5.43e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 5.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMlFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLD-RFGSKTVIALSIFFws 96
Cdd:cd17474 198 RGLLTFL-VSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLL-- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 97 fFTLLQGAIGFFsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17474 275 -YALSLLLLGFV---PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
170 180
....*....|....*....|....
gi 489316433 177 FGWHSVFVVMGAAGILLAVIWLKT 200
Cdd:cd17474 351 FGLSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
58-199 |
5.55e-09 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 57.76 E-value: 5.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSiffwsfftLLQGAIGFFSAGTAIILLFAL--RFLVGLSEAPSFPGN 135
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVS--------LLVETVGLLLLWLAPTAWVALagAALTGAGCSLIFPAL 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489316433 136 GRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMG---AAGILLAVIWLK 199
Cdd:PRK12382 324 GVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAisaVLGIIVTILSFR 390
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-433 |
6.31e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 57.56 E-value: 6.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFF 98
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 TLLQgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFpSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG 178
Cdd:cd17352 82 LLLS-----SFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 179 WHSVFVVMGAAGILLAViwlktvyepkkhpkvnkaelayieqgGGLISmddskskqeteskwpyikQLLTNRM----LIG 254
Cdd:cd17352 156 WRGALLILGGLCLNLCV--------------------------CGLLL------------------RLLKDPTfvllALG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 255 VYIAQYCITTLTYFFltwfPVYLVQaRGMSILEAGFVASLPALCGFAGGVLGGIVSDilLKKGRSLTFARKAPIIVGMLL 334
Cdd:cd17352 192 VSFAMLGFFVPFVYL----PSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 335 SCSMVVCNYTdsawlVVVIMSLAF-FGKG-FGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSF 412
Cdd:cd17352 265 LAFPLATTYV-----GLIVFSVLFgFCSGsYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDY 339
|
410 420
....*....|....*....|.
gi 489316433 413 NGALVFVGANAIAAILSYLLL 433
Cdd:cd17352 340 DAAFYFCGACLLLSGVLLFLL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
47-209 |
7.00e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.58 E-value: 7.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVialsiFFWSFFTLLQGAIGFFSAGTAIILLFALRFLVGL 126
Cdd:COG2223 233 VDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV-----LLIVFALMALGLLLLALALGSLWLFLVLFLLLGL 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG-WHSVFVVMGAAgILLAVIWLKTVYEPK 205
Cdd:COG2223 308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVL-ALVALVLTLLLYRRP 386
|
....
gi 489316433 206 KHPK 209
Cdd:COG2223 387 RRAA 390
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
17-235 |
2.43e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 56.23 E-value: 2.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 17 VRWFIVFMLFLVTSInyADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKtvialSIFFWS 96
Cdd:TIGR00711 1 LLLTIVLMLGTFMAV--LDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTR-----RLFLIS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 97 FFTLlqgAIGFFSAGTA--IILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLT 174
Cdd:TIGR00711 74 TFAF---TLGSLLCGVApnLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWII 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489316433 175 HSFGWHSVF---VVMGAAGILLAVIWLKTvYEPKKHPKVNKAELAYIEQGGGLISMDDSKSKQE 235
Cdd:TIGR00711 151 ENYHWRWIFlinVPIGIIVVVVAFFILPR-DKPAASENFDFLGLLLLSVGLGSLLYGLSEGPER 213
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
46-435 |
2.67e-08 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 55.70 E-value: 2.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAigffsaGTAIILLFALRFLVG 125
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL------ASGVIMLTLSRFIVG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 126 LSEAPSFP-GNGRVVASWfPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVmGAAGILLaVIWLKtvyep 204
Cdd:PRK12307 118 MGMAGEYAcASTYAVESW-PKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLL-VIYIR----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 205 KKHPKVNKAELAYIEqggglismDDSKSKQETESKWPYIKQLLTNR----MLIGVYIAQYCITTLTYFFLTWFPVYLVQa 280
Cdd:PRK12307 190 ARAPESKEWEEAKLS--------GKGKHSQSAWSVFSLSMKGLFNRaqfpLTLCVFIVLFSIFGANWPIFGLLPTYLAG- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 281 rgmSILEAGFVASLPALCGFaGGVLGGIVSDILLKKgrsltFARKAPIIVGMLLS----CSMVVCNYTDSAWLVVVIMSL 356
Cdd:PRK12307 261 ---EGFDTGVVSNLMTAAAF-GTVLGNIVWGLCADR-----IGLKKTFSIGLLMSflfiFPLFRIPQDNYLLLGACLFGL 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489316433 357 AFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGALVFVGANAIAAIlsyLLLVG 435
Cdd:PRK12307 332 MATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMG-LGAALTFIVAFWTATI---LLIIG 406
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
20-433 |
3.97e-08 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 55.10 E-value: 3.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 20 FIVFMLFLVT--SINYADRATLSitgdsvqhDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:PRK11663 29 YLGYALFYFTrkSFNAAMPEMLA--------DLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLqgaIGFFSAGTAIILLFALR-FLVGLSeapsFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:PRK11663 101 INIL---FGFSSSLWAFALLWVLNaFFQGWG----WPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 177 FGWHSVFVVMGAAGILLAVI--W-LKTVYEPKKHPKVNK-----AELAYIEQGGGLismddskSKQETESKW----PYIK 244
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGLFlcWrLRDKPQAMGLPSVGEwrhdaLELAQQQEGAGL-------SRKEILTKYvllnPYIW 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 245 QLLTNRMLigVYIAQYCITtltyfflTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGR---SLT 321
Cdd:PRK11663 247 LLSFSYVL--VYVVRAAIN-------DWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRgpmNLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 322 FArkapiiVGMLLSCSmvvcnytdSAWLV----VVIMSLAFFGKGFGALGWAVV-----SDTSPKECAGLSGGLFNTFGN 392
Cdd:PRK11663 318 FA------AGILLSVG--------SLWLMpfasYVMQAACFFTIGFFVFGPQMLigmaaAECSHKEAAGAATGFVGLFAY 383
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 489316433 393 I-ASITtpiiiGY---IVNATGSFNGALVFVganAIAAILSYLLL 433
Cdd:PRK11663 384 LgAALS-----GYplaKVLEIWHWTGFFVVI---SIAAGISALLL 420
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-198 |
4.06e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTsINYADRATLSITGdsvqHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFF 98
Cdd:cd17370 203 WLYLLAVALFA-LGNFSFAFLILRA----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 TLLqgaIGFFSAGTAIILLFALRFL-VGLSEapsfpGNGR-VVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17370 278 YLG---FALGSSLWLLLLGFILWGLyMGAQE-----SIERaAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL 349
|
170 180
....*....|....*....|..
gi 489316433 177 FGWHSVFVVmGAAGILLAVIWL 198
Cdd:cd17370 350 ISPSAAFLF-SAVLALIALLLL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-198 |
5.35e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.48 E-value: 5.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFfwsfftLLQGAIGFFSAGTAIILLFALRFLVGL 126
Cdd:cd17324 226 TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL------LAAALLLLTLLGPSPLLLLVGLVLWGL 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489316433 127 SEAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWL 198
Cdd:cd17324 300 GFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-420 |
8.40e-08 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 53.95 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLQGAigffsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17314 81 GYTYLSY-----VFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 178 GWHSVFVVMGAAgiLLAVIWLKTVYEPKKHPKVNKAELAYieqGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYI 257
Cdd:cd17314 155 GLALVYTILGIL--AAIVLSVVSLLGFKEPPDNQARLHVQ---KKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANM 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 258 AQYcittltyffltwfpvylvqARGMSILEAGFVA---SLPALCGFAGGVLGGIVSDILLKKGRSLTFARkapIIVGMLL 334
Cdd:cd17314 230 ASL-------------------VRSLQLDAPSFVTklmSIYGLFNAFGRLLWGIVADFFGGRLSTLSILL---TILGLGL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 335 SCSMVVCNYTDSaWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNG 414
Cdd:cd17314 288 CAFLFLLKMTPV-GLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYIS 366
|
....*.
gi 489316433 415 ALVFVG 420
Cdd:cd17314 367 AVYIYA 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-206 |
8.74e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.09 E-value: 8.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaigFFSAGTAIILLFALrFLVG 125
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL-----ALLAPGPWLALIGL-ALVG 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 126 LSEAPSFPGNGRVVASWFPSSERGTASAFFNSAqYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPK 205
Cdd:COG0738 311 LGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
.
gi 489316433 206 K 206
Cdd:COG0738 390 K 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-167 |
2.52e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.42 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFfwsFFTLL 101
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL---LLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489316433 102 QGAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFS 167
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-446 |
2.68e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.42 E-value: 2.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 255 VYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKAPIIVGMLL 334
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 335 SCSMVVC--NYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSF 412
Cdd:pfam07690 72 FALGLLLllFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170 180 190
....*....|....*....|....*....|....
gi 489316433 413 NGALVFVGANAIAAILSYLLLVGPIKRVVLKKQE 446
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEE 185
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
50-197 |
2.99e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.18 E-value: 2.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIffwsfFTLLQGAIGFFSAGTAIILLFALRFLVGLSEA 129
Cdd:cd17477 218 LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA-----LLGALAALLLPLVPGLPLALLVLLFLWGGAAG 292
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489316433 130 PSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIW 197
Cdd:cd17477 293 PLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
44-364 |
3.80e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.81 E-value: 3.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 44 DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTllqgaIGFFSAGTaIILLFALRFL 123
Cdd:cd17323 23 PQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ-----IGCALAPN-IAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 124 VGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVF---VVMGAAGILLAVIWLKT 200
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwflAIISGFCLILIFLFLPI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 201 VyepkkhpkvnkaelayieqggglismddskskqeteskwpyikqlltnrMLIGVYIA-QYCIttlTYFFLTWFPVYLVQ 279
Cdd:cd17323 177 V-------------------------------------------------LLLGLYVGlVYAI---LYLFLTAFPYVFGE 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 280 ARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKK------GRSLTFARKAPIIVGMLLSCSMVV----CNYTDSAWL 349
Cdd:cd17323 205 VYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlkkkngGKPEPEARLPPAFIGAFLFPIGLFifgwTIYPHIHWI 284
|
330
....*....|....*
gi 489316433 350 VVVIMSlAFFGKGFG 364
Cdd:cd17323 285 VPIIGS-AFFGFGLM 298
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
48-434 |
4.31e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 4.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaIGFFSagtAIILLFALRFLVGLS 127
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL---LGFAH---SPWLFAIALVLTGFG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 128 EAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWL-THSFGWhsVFVVmGAAGILLAVIWLKTVYEPKK 206
Cdd:cd17329 102 GGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLlLYSFRL--LFLA-AAVLFLLAALVLLFLLPETR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 207 HPKVNkaelayieqggglismddsksKQETESKWPYiKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSIL 286
Cdd:cd17329 179 PKRRA---------------------AEKTEILRGY-KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 287 EAGFvasLPALCGFAGGVLGGIVSDILLKKGRSLTfarkapIIVGMLL-SCSMVVCNYTDSAWLVVVIMSLAFFGK--GF 363
Cdd:cd17329 237 LLGL---LLALNALLIVLLQFPVARLVERFRLRKI------LMIGILLfAIGFAVLAFANTLAVLILAMIVLTLGEmlVF 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489316433 364 GALGwAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGALVFVGANAIAAILSYLLLV 434
Cdd:cd17329 308 PAVQ-TLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
252-449 |
5.98e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 5.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 252 LIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKAPIIVG 331
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR---------FGRKPVMLAG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 332 MLLS-CSMVVCNYTDSAWLVVVIMSLAFFGKG-FGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNat 409
Cdd:cd17329 72 LLLRaLGFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 489316433 410 gsFNGALVFVgANAIAAILSYLLLVGPIKRVVLKKQEQDP 449
Cdd:cd17329 150 --YSFRLLFL-AAAVLFLLAALVLLFLLPETRPKRRAAEK 186
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
47-196 |
8.86e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 8.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaIGFFSAGTAIILLFALRFLVGL 126
Cdd:cd17321 196 QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL---LALLGADSSVWLLLPGLVLLGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY----FAIVIFSPLMGWLTHSF-------------------GWHSVF 183
Cdd:cd17321 273 GLGLFATPLTNAALSSVPKEKAGAASGILNTARQlggaLGVALLGALLTAGLSANlgdsgvaallsaaaaafaaGFHLAF 352
|
170
....*....|...
gi 489316433 184 VVMGAAGILLAVI 196
Cdd:cd17321 353 LVAAALALLAALL 365
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
57-433 |
1.06e-06 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 50.70 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTvialsIFFWSFFTLLQGAIGFFSAGTAIILLFALrFLVGLSEAPSFPGNG 136
Cdd:PRK03699 44 MSNTFTFLNAGILISIFLNAWLMEIIPLKR-----QLIFGFALMILAVAGLMFSHSLALFSIAM-FVLGVVSGITMSIGT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 137 RVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW-LTHSFGWHSVFVVMGAAGILLAVIWLKTVYepkkhPKVNKAEl 215
Cdd:PRK03699 118 FLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYlLARSIEWYWVYACIGLVYVAIFILTLFSEF-----PALGKHA- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 216 ayieqggglismdDSKSKQETESKWpyikqlltNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASlp 295
Cdd:PRK03699 192 -------------PKADKPVAKEKW--------GIGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVS-- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 296 alcGFAGG-VLGGIVSDILLKKGRSLTFarkapIIVGMLLSC-SMVVCNYTDS-AWLVVVIMSLAFFG----KGFGALGW 368
Cdd:PRK03699 249 ---NFWMAyMVGMWIFSFIVRFFDLQRI-----LTVLAGLALvLMYLFVNTDDpSHLLYAILGLGFFSsaiyTTIITLGS 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489316433 369 AVVSDTSPKecaglsggLFN---TFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:PRK03699 321 QQTKVASPK--------LVNfilTCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVFVMCILLG 380
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-216 |
1.32e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTSINYADRATLSITgdSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFF 98
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLY--YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 99 TLLqgaiGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSE-------RGTASAFFNSAQYFAIVIFSPLMG 171
Cdd:COG2211 308 LLL----LFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAG 383
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 489316433 172 WLTHSFGWHS--------------VFVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELA 216
Cdd:COG2211 384 LLLALFGYVAgaaqspsaltgirlLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
61-432 |
1.47e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 50.22 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 61 FSAFGWAYV---IGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAI-GFFSAGT-AIILLFALRFLVGLSEAPSFPGN 135
Cdd:cd17369 47 FATFGVGFLarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLpTYAQIGIlAPILLVLLRLLQGLALGGEWGGA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 136 GRVVASWFPSSERGTASAF----FNSAQYFAIVIFSPLMGWLTH----SFGWHSVFVVmgAAGILLAVIWLKTvyepkkh 207
Cdd:cd17369 127 VLMAVEHAPPKRRGFYGSFpqlgAPVGLLLATGVFLLLSALLSDeaflSWGWRIPFLL--SAVLVAVGLYIRL------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 208 pkvnkaelayieqgggliSMDDS----KSKQETESKWPYIKQLLTN--RMLIGVYIAQYCITTLTYFFLTWFPVYLVQAR 281
Cdd:cd17369 198 ------------------RLEETpvfrRAKEAGQVVRAPLVEVLRRhwRALLLAIGLRLAENVLFYLFTTFALSYATQTL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 282 GMS---ILEAGFVASlpaLCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLscsMVVC--------NYTDSAWLV 350
Cdd:cd17369 260 GVDrstVLLAVLIAS---VVAAITIPLFGWLSD---------RVGRRPVYLAGALL---AALFafpffwllDTGSTWLIV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 351 VVIMSLAFFGKG--FGALGwAVVSDTSPKEC--AGLSGGlFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAA 426
Cdd:cd17369 325 LAAVVVLGVLHGmmYGPQA-AFLAELFPTRVryTGASLG-YQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVIS 402
|
....*.
gi 489316433 427 ILSYLL 432
Cdd:cd17369 403 LVAALF 408
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-198 |
2.17e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 49.50 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 37 ATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQgAIGFFSAGTAIIL 116
Cdd:cd17320 219 AYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL-LLAALLGGLSLWP 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 117 LFALRFLVGLSEAPSFPGNGRVVASWFPsSERGTASAFFNSAQYFAIVIFSPLMGWLtHSFGWHSVFVVMGAAGILLAVI 196
Cdd:cd17320 298 LVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL-PNGTALPMGLLILVLGLLALLL 375
|
..
gi 489316433 197 WL 198
Cdd:cd17320 376 LI 377
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
38-430 |
2.17e-06 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 49.65 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 38 TLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLlqgAIgFFSAGTAIILL 117
Cdd:cd17396 18 ILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV---GI-LFSPNLIIAYV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 118 FAlrFLVGLseAPSFPGNGRVVA--SWFPSSErGTAS----AFFNSAQYFAIVIFSPLMgWLTHSFGWhsVFVVMGAAGI 191
Cdd:cd17396 94 FA--LLAGA--ANSFLDTGTYPAlmEAFPKAS-GSANilvkAFVSFGQFLLPFIIAFLA-ANNLWYGW--SFIVPAAVLV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 192 LLAVIWLKTVYEPKKHPKVNKAelayieqggglismddsksKQETESKWPYIKQLLTNRMLIgvyIAQYCITTLTYFFLT 271
Cdd:cd17396 166 LNALLLLKLSFPPQTVTAANTK-------------------QKEIPVKREKPKFLIEGIALI---LIGFTSTATFYLFSQ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 272 WFPVYLVQARGMSILEAGFVASLPALcgfaGGVLGGIVSDILLKKGRSLTFARKAPIIVGMLLSCSMVVCNYTDsawlvv 351
Cdd:cd17396 224 WMPKYGSAVAGMGEAESLKLISYYSM----GSLVCVFITAVLLKRYVRPIWILVLYPIISLLALFVLYLVPSPD------ 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 352 VIMSLAFFGKGFGA-----LGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATG-----SFNGALVFVGA 421
Cdd:cd17396 294 VCILGAFVIGFFAAggvlqLGLTLMAEFFPKG-KGKVTGIYMIASSLANFVIPLITGIIASAIGiayifLFDFGIALLGL 372
|
....*....
gi 489316433 422 nAIAAILSY 430
Cdd:cd17396 373 -LLAIFVFI 380
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
58-428 |
3.25e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFwsfftLLQGAIGFFSAGTAIILLFAlRFLVGLSEAPSfpgngr 137
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLL-----FIAGSLLAAYATSIYGLILG-RALQGSGAISS------ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 138 VVASWF----PSSERGTASAF---FNSAQYFAIVIFSPLmgwLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPKKHpkv 210
Cdd:cd17472 103 VVMALLadltREENRTKAMALigaSIGIAFAISMVLGPL---LAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKI--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 211 nkaelayieqggglismddsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEagF 290
Cdd:cd17472 177 ----------------------VQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQL--W 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 291 VASLPALcgFAGGVLGGIVSDILLKKGRSLTFARKApiIVGMLLSCSMVVCNYTDsawLVVVIMSLAFFGKGFG---ALG 367
Cdd:cd17472 233 KVYLPAI--LIGFILMVPFVIYAEKKGKMKQVFVSS--ILLIAVGFLLLLFAATS---LWLLIIGLIIFFIGFNlleALL 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489316433 368 WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVnatGSFNGALVFVGANAIAAIL 428
Cdd:cd17472 306 PSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW---GLLGYSSVFLTILILALLW 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-433 |
5.42e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 5.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 250 RMLIGVYIAQYCITTLTYFFLTWFPvYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKAPII 329
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR---------FGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 330 VGMLL-SCSMVVCNYTDSAWLVVVIMSL-AFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVN 407
Cdd:COG2814 80 LGLLLfALGSLLCALAPSLWLLLAARFLqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*.
gi 489316433 408 ATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
49-212 |
1.24e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 47.22 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFwsfFTLlqgaIGFFSAGT-AIILLFALRFLVGLS 127
Cdd:PRK11102 20 DFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLV---FAL----AAVACALAqTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 128 EAPSFPGNGRVVASWFPSSErgtasafFNSAQYFAIVIF--SPLM-----GWLTHSFGWHSVFVVMGAAGILLAV-IWLK 199
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEE-------FSRMMSFVTLVMtiAPLLapiigGWLLVWFSWHAIFWVLALAAILAAAlVFFF 165
|
170
....*....|...
gi 489316433 200 TvyePKKHPKVNK 212
Cdd:PRK11102 166 I---PETLPKERR 175
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-196 |
3.06e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaigFFSAGTaiILLFALRFLVGLS 127
Cdd:cd17478 223 VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL-----FLLTPG--IWSYILLVLAGFL 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489316433 128 EAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVI 196
Cdd:cd17478 296 LFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
46-199 |
4.07e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 45.84 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQG-AIGFFSagtaiilLFALRFLV 124
Cdd:PRK03893 46 VQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGfAPGYWT-------LFIARLVI 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489316433 125 GLSEAPSFPGNGR-VVASWfPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVmGAAGILLAViWLK 199
Cdd:PRK03893 119 GMGMAGEYGSSATyVIESW-PKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI-GILPIIFAL-WLR 191
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-432 |
4.38e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.65 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGaigfFSagTAIILLFALRFLVG 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA----FA--PNLPVLIAGRALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 126 LSeAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAViwlktvyepk 205
Cdd:cd17504 96 IG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA---------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 206 khpkvnkaelayieqgggLISMDDSKskqeteskwpyikqLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQAR---- 281
Cdd:cd17504 165 ------------------LVPLIDLR--------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgf 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 282 GMSILEAGFVASLPALCGFAGGVLGGIVSdillkkgrSLTFARKAPII--VGMLLSCSMVVCNYTdSAWLVVVIMSLAFF 359
Cdd:cd17504 213 GLGITEAGLLLLPGALVMLIAGPLAGRLI--------ARVGPRRVLLIglVISAVGLLLLALLHS-SLWALVVALLLIGI 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 360 GKG--FGALGWAVVSDTSPKECA---GLSGGLFNTFGNIASI---------TTPIIIGYIVNATGSFNGALVFVGANAIA 425
Cdd:cd17504 284 GLGlaFASLPNIVVESVPPDRTGiatGMNTVLRTIGSAIGPAiagailttyTVSITSGGVPTEGAYVLAFLIGAALALAA 363
|
....*..
gi 489316433 426 AILSYLL 432
Cdd:cd17504 364 LLLSLLI 370
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
18-433 |
4.55e-05 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 45.47 E-value: 4.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSF 97
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 FTLLQgAIGFFSAGTAIILLFAlRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVI---FSPLMGWLT 174
Cdd:cd17334 82 GSVLK-CIPLGQQPKFALLVLG-QVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIgflLPPVVVPPP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 175 H--------SFGWHSVFVVMgaagILLAVIWLktvYEPKKHPKVNKAELAYIEQGGGLISMDDSKSKQETESkwPYIKQL 246
Cdd:cd17334 160 KgtkkefgaVFYGEFGFACL----LLALVLAL---FPPKPKYPPSAASARQQNSEHVILELQKSISELLRNE--PFVLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 247 LTNRMLIGVYIAqycittltyffltwFPVYLVQArgmsILEAGFVASLPALCGFAGGVlGGIVSDILLkkGRSLTFARKA 326
Cdd:cd17334 231 VAFSIMMGVFAG--------------FSSVLAQI----LLPFGVSQTSAGWLGFFGIV-AGMVGGLLL--GLFVDRTRMF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 327 PIIVGMLLSCSMVVCNYT----------DSAWLVVVIMS-LAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIAS 395
Cdd:cd17334 290 KLIGLIILALGTVVCTFFmllvdryglpYVTLAFYLLCGlLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFS 369
|
410 420 430
....*....|....*....|....*....|....*...
gi 489316433 396 ITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17334 370 FLLMLVFSELLGPTPTESKYLLWFILCTVGSCLGALFF 407
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
49-434 |
5.35e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIalsIFFWSFFTLLqGAIGFFSAGTAIILLFAlRFLVGLSE 128
Cdd:cd17490 25 SLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLF---IIIGLLFTVL-ASLIMILFPSPWGLLIA-RFLSGIAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 129 AP--SFPgngRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTVYEPKK 206
Cdd:cd17490 100 ATwvSFT---VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 207 HPKVNKaelayieqggglismddskskqetesKWPYIKQLLTNRMLIGVY---IAQYCITTLTYFFLTwfPVYLVQArGM 283
Cdd:cd17490 177 KKPVLT--------------------------ELKELLSVLKDKKLLFFSllaILQQMITFSTTFGFT--PLIAKQL-GA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 284 SILEAGFVASLPALCGFAGGVLGGIVsdILLKKGrsltfARKAPIIVGMLLSCSMVVCNYTDSAWLVVVIMSLAFFGKG- 362
Cdd:cd17490 228 SSFQLGLLSIIYLLPNALASLLSGTL--FYKKLG-----ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGi 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489316433 363 -FGALGWAVVSDTsPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGALVFVGANAIAAILSYLLLV 434
Cdd:cd17490 301 lFPLLMSLSIEGV-PAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
50-374 |
6.00e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.29 E-value: 6.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSK-----------TVIALSIFFWSFFTLLQGAIGFFSAGTAIILLF 118
Cdd:cd17332 30 LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRwgrfrpwllwgAIPLALLFVLLFTTPDGSGTGKLIYALITYILL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 119 ALRF-LVGLSeapsfpgngrvVASWFP-----SSERGTASAFF----NSAQYFAIVIFSPLMGWLTH---SFGWHSVFVV 185
Cdd:cd17332 110 DLLYtLVNIP-----------YTALIPeltddPEERTSLTSWRmffaTIGGLLVTVLPPPLVAYFGGgnaSRGYFLTALI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 186 MGAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEQggglismddskskqeteskwpyIKQLLTNRMLIGVYIAQYCITTL 265
Cdd:cd17332 179 IGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKS----------------------LKALLKNRPFLILLLAYLLYFLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 266 TYFFLTWFPVYLVQARGmsileaGFVASLPALCGFAGGVLGGIVSDILLKKgrslTFARKAPIIVGML---LSCSMVVCN 342
Cdd:cd17332 237 FNIVNTVLVYYFKYVLG------GRAELVLLLLLILSGALLALLPWPPLKK----RFGKKKAFFIGLLlaiLGLLLLFFL 306
|
330 340 350
....*....|....*....|....*....|...
gi 489316433 343 YTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDT 374
Cdd:cd17332 307 PPGNLVLILVLAVLAGIGYGGAnLLPWAMLADV 339
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
67-196 |
6.76e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 44.93 E-value: 6.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 67 AYVIGQLPGGWLLDRFGSKTVIALSIFFwsfFTLLQGAIGFFSAGTAIILLFALrflVGLSEAPSFPGNGRVVASWFPSS 146
Cdd:cd17313 293 AFLIFSLPIGKLGKKIGRKKVYLIGLVL---FAVGMALMALVHNVTVALVLFAL---GGIGWATININPYPLVSDYHSES 366
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489316433 147 ER--GTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVI 196
Cdd:cd17313 367 GRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVG 418
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
61-433 |
7.65e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 44.67 E-value: 7.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 61 FSAFGWAYV---IGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQG------AIGFfsAGTAIILLfaLRFLVGLSEAPS 131
Cdd:cd17368 43 FATFGVGFFmrpIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIAlaptyaTIGI--AAPLLVLL--ARLLQGFAAGGE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 132 FPGNGRVVASWFPSSERGTASAFFNSAQYFAIViFSPLMG-----WLTH----SFGWHSVFVVmgaaGILLAVI--WLKT 200
Cdd:cd17368 119 VGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIV-AGALVGyllslTLTAealaEWGWRIPFFI----GLLIIPLglWLRR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 201 VYEPkkhpkvNKAELAyieqggglismddSKSKQETESkwpYIKQLLTNR--MLIGVYIAQYCiTTLTYFFLTWFPVYLV 278
Cdd:cd17368 194 SLEE------TEAFLE-------------RKARPTRRE---LFALLANNRriILLGMLLVAGS-TVTFYFTTVYTPTYAK 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 279 QARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKAPIIVGMLLSCSMV------VCNYTDSAWLVVV 352
Cdd:cd17368 251 TVLGLSARDSFLVTLLAGVANFIWAPLGGALSD---------RIGRRPVLLVITLAALVTLypvfawLTAAPSFGRLLLV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 353 IMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFG-NIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYL 431
Cdd:cd17368 322 LLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLATL 401
|
..
gi 489316433 432 LL 433
Cdd:cd17368 402 ML 403
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
57-364 |
1.16e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.09 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAigffsAGTAIILLFAlRFLVGLSEAPSFPGNG 136
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL-----APNMTMLIVG-RAIQGIGGGGLMSLAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 137 RVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWlktvyepkkhpkvnkaela 216
Cdd:cd17502 106 IIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 217 yieqggglismddskskqeteskwpyikqlltnRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGfVASLPA 296
Cdd:cd17502 167 ---------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSG-VRLLPL 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489316433 297 LCGFaggVLGGIVSDILLKKGRSLtfarKAPIIVGMLLscsMVVC-------NYTDSAWLVVVIMSLAFFGKGFG 364
Cdd:cd17502 213 IIGL---VIGSIISGALISKTGRY----KPLIVIGTIL---MSVGagllttlTLDTSKWLLIGYLILLGLGLGIG 277
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
48-198 |
1.73e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLqgaigfFSAGTAIILLFALRFLVGLs 127
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL------LALTDSPWVWFLLRFVMGI- 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489316433 128 eapSFPGNGRVVASWF----PSSERGTASAFFNSAQYFAIVIfSPLMGWLTHSFGWhsVFVVMGAAGILLAVIWL 198
Cdd:cd17477 97 ---GLAGLFVVSESWLnalaTNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGA--LPFLIAAVLLLLALVPL 165
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
19-196 |
1.94e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 19 WFIVFMLFLVTSINYADRATLSitgDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLL-DRFGSKTVIALSIffwsf 97
Cdd:cd17490 197 LFFSLLAILQQMITFSTTFGFT---PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGF----- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 98 ftLLQGAIGFFSAGT-AIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17490 269 --LLLGAYCFLIPFApNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEA 346
|
170 180
....*....|....*....|
gi 489316433 177 FGWHSVFVVMGAAGILLAVI 196
Cdd:cd17490 347 FGLQTGFFVIGVIALLAAIL 366
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
45-198 |
1.97e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 43.53 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 45 SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLlqGAIGFFSAGTaiilLFALRFLV 124
Cdd:TIGR00710 30 EIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL--GLALSNNIET----LLVLRFVQ 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489316433 125 GLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILL-AVIWL 198
Cdd:TIGR00710 104 AFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLsALIFF 178
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
57-359 |
2.06e-04 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 43.46 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAI----GFFSAgtaiILLFALRFLVGLSEAPSF 132
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLtewlHFYNK----YLYCILWVLNGLLQSTGW 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 133 PGNGRVVASWFPSSERGTASAFFNSAqyfAIV--IFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLktvyepkkhpkv 210
Cdd:cd17342 141 PCVVAIMGNWFGKSSRGFVLGLWSAC---ASVgnIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVF------------ 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 211 nkaeLAYIEQGGGLIsmddskskqeteskwPYikqlltnrmligvYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGF 290
Cdd:cd17342 206 ----FGLLSSPPGVI---------------PY-------------SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQ 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489316433 291 VASLPALCGFAGGVLGGIVSDILLKkgrsltfarKAPIIVGMLLSC--SMVVCNYTDSAWLV-VVIMSLAFF 359
Cdd:cd17342 254 LSIWYDVGGIIGGIVAGYISDRMGS---------RSPVVVVMLLLAipSLFVYSHSPSDKVLnAFVMTITGF 316
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
265-428 |
2.45e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 265 LTYFFLTWFPVYLVQaRGMSILEAGFVASLPALCGFAGGVLGGIVSDiLLKKGRSLTFARKAPIIVGMLlscsMVVCNYT 344
Cdd:cd17339 211 LFYTLMAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLLVPILAT-RLKNQRPIVVLLAVLFIIGVL----GLLFAPT 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 345 DSAWLVVVIMSLAFfGKGFG-ALGWAVVSDTSPKECAGLSGgLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANA 423
Cdd:cd17339 285 ALALLWAVLLGLGG-GAAFSlALTLISLRSSDPAEAAALSG-MAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALT 362
|
....*
gi 489316433 424 IAAIL 428
Cdd:cd17339 363 VLQLV 367
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
47-214 |
2.99e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.68 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAIGFFsagtaiILLFALRFLVGL 126
Cdd:cd06180 26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGF------AALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIfSPLMGWLTHSFGWHSV---FVVMGAAGILLAVIWLKTVYE 203
Cdd:cd06180 100 ASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIAL-SGLLVPAGLGGGLSWRagwLALALLSAVLLLLSFLLLRRG 178
|
170
....*....|.
gi 489316433 204 PKKHPKVNKAE 214
Cdd:cd06180 179 PSAPTEASAAE 189
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
50-433 |
3.32e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 3.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSiffwsfftllqgaigfFSAGTAIILLFALR---FLVGL 126
Cdd:cd17331 30 LGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLS----------------FLSSALSYLLLAFAssvPMLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 127 SEAPS-----FPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKTV 201
Cdd:cd17331 94 SRLPSvfmhaMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 202 YEPKKHPKVNKAElayiEQGGGLISMDDSKSKQETesKWPYIKQLLTNRMLIGVYIAQYCITtltyffltwFPVYLVQAR 281
Cdd:cd17331 174 PSNTKSKREKEAK----ESASPPSVFNLKEILRLL--RLPGVAFLLLVKLLSGLPIGMFQSM---------FSLVAMDFF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 282 GMSILEAGFVASlpaLCGFAGGVLGGIVSDILLKKG--RSLTFARKAPIIVGMLLSCSMvvcnyTDSAWLVVVIMSLAFF 359
Cdd:cd17331 239 GLTPEENGYLMS---YAGVLGMVVQGLLVGPLTKRFgeRSLLKLSVALLAIGYLLLAFV-----TTVWQLLVLLLPLVIG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489316433 360 GKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSfnGALVFVGANAIAAILSYLLL 433
Cdd:cd17331 311 GSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF--PSFGLLGAAINGLLTVYLLL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
267-433 |
5.12e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.18 E-value: 5.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 267 YFFLTWFPVY--------LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKAPIIVGMLLSC-S 337
Cdd:COG2223 13 AFFLAFGVWYlwsvlappLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDR---------FGPRRVLLIGLLLLGiG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 338 MVVCNYTDSAWLVVVIMSLAFFGKGFGALGW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGAL 416
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGiALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170
....*....|....*..
gi 489316433 417 VFVGANAIAAILSYLLL 433
Cdd:COG2223 164 ILGILLLVVAVLAWLFL 180
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
18-391 |
5.30e-04 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 42.34 E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 18 RWFIVFM-LFLVTSINYAD----RATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSI 92
Cdd:PRK09556 22 MWFKPFMqSYLVVFIGYLTmyliRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 93 FFWSFFTLLQGAIgFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW 172
Cdd:PRK09556 102 ILSAICMLGFGAS-LGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 173 LTHSFGWHSV---FVVMGAAGILLAVIWLKTVYEPKKHPKVNKAELAYIEQggglISMDDSKSKQETESKWPYIKQ-LLT 248
Cdd:PRK09556 181 GANYFFDGHVigmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEP----ISEEDKETESTDMTKWQIFVEyVLK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 249 NRML-------IGVYIAQYCITtltyfflTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDiLLKKGRSLT 321
Cdd:PRK09556 257 NPVIwllcfanIFLYIVRIGID-------NWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSD-LANGRRALV 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489316433 322 FARKAPIIVGMLLScsmvvcnYTDSAWLVVVIMSLAFFGK-GFGA---LGWAVVSdTSPKECAGLSGGLFNTFG 391
Cdd:PRK09556 329 ACIALALIIFTLGV-------YQHATSEYMYLASLFALGFlVFGPqllIGVAAVG-FVPKKAIGVANGIKGTFA 394
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
49-198 |
6.52e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 49 DLGLDSVAMGYVFSAFGWAYVIGQLP-GGWLLDRFGSKTVIALSIFFWSFFTLLQGAIGFFSagtaiiLLFALRFLVGLS 127
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFG 277
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489316433 128 EAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAiVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWL 198
Cdd:cd17330 278 TGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLA-RIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
44-217 |
1.90e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 40.26 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 44 DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIffwSFFTLlqGAIGFFSAGTAIILLfALRFL 123
Cdd:PRK11043 30 KAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGL---SLFAL--GSLGMLWVESAAQLL-VLRFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 124 --VGL-SEAPSFPGngrVVASWFPSSErgtasaffnSAQYFA----IVIFS----PLMG-WLTHSFGWHSVFVVMGAAGI 191
Cdd:PRK11043 104 qaVGVcSAAVIWQA---LVIDRYPAQK---------ANRVFAtimpLVALSpalaPLLGaWLLNHFGWQAIFATLFAITL 171
|
170 180
....*....|....*....|....*.
gi 489316433 192 LLAVIWLKTVyEPKKHPKVNKAELAY 217
Cdd:PRK11043 172 LLILPTLRLK-PSKKARKQSQDALTF 196
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
58-200 |
2.11e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAigffsAGTAIILLfALRFLVGLSEAPSFPGNGR 137
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAF-----VQTPWQLG-ILRFLLGLATGGLLPAINS 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489316433 138 VVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMgAAGILLAVIWLKT 200
Cdd:cd17391 317 LLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVT-ALLVLLNAIWSFI 378
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
49-434 |
2.15e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.33 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAIGffsAGTAIILLFALRFLVGLse 128
Cdd:pfam00083 40 SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAK---GKWSVYQLIVGRVLVGI-- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 129 apsFPGNGRVVASWF-----PSSERGTASAFFNSAQYFAIV---IFSPLMGWLTHSFGWHSVFVVMGAAGILLAVIWLKT 200
Cdd:pfam00083 115 ---GVGGASVLAPMYiseiaPKKLRGALGSLYQLAITFGILlayIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 201 VYEPKKHPKVNKAELA--YIEQGGGLISMDDS------KSKQETESKWPYIKQLLTN-----RMLIGVYIAqyCITTLT- 266
Cdd:pfam00083 192 PESPRWLVEKGRLEEAreVLAKLRGVPDVDREldeikdSLEAGQEAEKASWKELFSTktrrqRLLIGVMLQ--IFQQLTg 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 267 YFFLTWFPVYLVQARGMSileAGFVASLPALCGFAGGVLGGI-VSDillKKGRSLTFARKAPIIVGMLLSCSMVVCNYTD 345
Cdd:pfam00083 270 INAIFYYSTTIFENLGLS---DSFLVTIIVGVVNFVFTFIAIfLVD---RFGRRPLLLLGAAGMAICFVILGIVALLGVS 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 346 SAW------LVVVIMSLAFFGKGFGALGWAVVSDTSPKE----CAGLSGGLFNTFGNIASITTPIIIGYIvNATGSFnga 415
Cdd:pfam00083 344 KSDwagivaIVFIALFIAFFAMGWGPVPWVIVSELFPLSvrskAMALATAANWLANFLIGFLFPIITDAI-GLGYTF--- 419
|
410
....*....|....*....
gi 489316433 416 LVFVGANAIAAILSYLLLV 434
Cdd:pfam00083 420 FIFAGLLVLFIIFVFFFVP 438
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
57-321 |
3.03e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 39.61 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGaIGFFSAGTAIILLFALRFLVGLSEAPSFPGNG 136
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 137 RVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMG-WLthSFGWHSVFVVMGAAGILLAVIwlktVYepkkhpkvnkaeL 215
Cdd:cd17344 143 ACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGiFV--SSAWGLSFIVPGIIIAAMGVL----VF------------L 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 216 AYIEQGGGLIsmddskskqeteskwPYIKQLLTNRMLigvyiaqycittlTYFFLTWFPVYLVQARGMSILEAGFVASLP 295
Cdd:cd17344 205 FLVEHPPGVI---------------EFSLCLFFAKLV-------------SYTFLYWLPLYISNTAILSAKKAGDLSTLF 256
|
250 260
....*....|....*....|....*.
gi 489316433 296 ALCGFAGGVLGGIVSDILlkKGRSLT 321
Cdd:cd17344 257 DVGGIVGGILAGYISDYT--GGRATT 280
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
70-434 |
3.11e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.59 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 70 IGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQGAI-GFFSAGTA--IILLFAlRFLVGLSEAPSFPGNGRVVASWFPSS 146
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTpTYATIGIWapIILLLA-RLLQGLSVGGEYGTSATYLSEVAPPG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 147 ERGTASAF----FNSAQYFAIVIFSPLMGWLT----HSFGWHSVFVVMGAAGilLAVIWLKTVYEPKKHpkvNKAELAYI 218
Cdd:cd17367 134 RRGFYSSFqyvtLIGGQLLALGVLLVLQHTLGedqmAAWGWRIPFLLGGVLA--VVVLWLRRGLEETES---FEAIAESN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 219 EQGGGLIsmddskskqetESKWPYIKQLLtnrMLIGVYIAQyciTTLTYFFLTWFPVYLVQARGMS---ILEAGFVASLP 295
Cdd:cd17367 209 EASAGTL-----------RELRRHPRELL---LVVGLTAGG---TLAFYTWTTYLQKFLVNTAGFSkgdATWITTAALLV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 296 ALcgfAGGVLGGIVSDILLKKGRSLTFArkapiIVGMLLSCSMVV-CNYTDSAWLVVVIMSLAF-FGKGFGALGWAVVSD 373
Cdd:cd17367 272 FM---LLQPLGGRLSDRIGRRPLLLFFG-----IGGTLATVPLLSaLDHTDSPYTAFALVLVGLvFLSGYTSINAVVKAE 343
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489316433 374 TSPKEC----AGLSGGLFNT-FGNIASittpiiigYIVNATGSFNGALVFVGANAIAAILSYLLLV 434
Cdd:cd17367 344 LFPTHVralgVGLPYALAVAiFGGTAP--------YVALWLKSIGHEWVFFWYVAGLIAISLVVYL 401
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
54-433 |
3.13e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.94 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 54 SVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVIALSIFFWSFFTLLQgaiGFFSAGTAIILLFALRFLVGLSEAPSFP 133
Cdd:cd17357 48 DLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLM---FLSKSAKSPELLIFGRFLVGIACGLSTG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 134 GNGRVVASWFPSSERGTASAFFNSAQYFAIVI-----FSPLMGWLTHsfgWHSVFVVMGAAGILLAVIWLKTVYEPK--- 205
Cdd:cd17357 125 FVPMYLQEISPSELRGALGSLTQIGVTLGILLgqvfgLPSVLGTETL---WPYLLFFPGIPALLQLAALPFFPESPKfll 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 206 -KHPKVNKAELA----YIEQGGGLISMDDSK--SKQETESKWPYIKQLLTN-----RMLIGVYIA---QYCITTLTYFFL 270
Cdd:cd17357 202 iSKGDEEEAEKSlkflRGIEDDVDQELEEIKkeSEQMGDQKQVSLMQLLRDpslrlPLLLVLVVSasqQFSGINAIFFYS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 271 TWFpvylvqargmsILEAGFVASLPALCGFAGG---VLGGIVSDILLKK-GRS--LTFARKAPIIVGMLLSCSMVVCNYT 344
Cdd:cd17357 282 TFI-----------FENAGFSPQLAEWANLGIGivnVLSTIVGPFLIEKvGRRplLLISLSVCAVALLLMSVFLFLSEQN 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 345 DS-AWLVVV--IMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNgALVFVGA 421
Cdd:cd17357 351 SWmSYGCIVaiFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFV-FIIFAIP 429
|
410
....*....|..
gi 489316433 422 NAIAAILSYLLL 433
Cdd:cd17357 430 CALFLLYLYRYL 441
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
49-196 |
3.42e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 39.52 E-value: 3.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 49 DLGLDSVAMGYVFSAFGW-AYVIGQLPGGWLLDRFGSKTVIALSIFF----WSFFTLLQGAIGFFSAGTAIILLFALRFL 123
Cdd:cd17485 236 DRGFSLSQIGLLSGVGGSlVSIAGSLLGGYLLKRRGRRRLLLLGGLLrlllLGLYTLLALGGSGLNWVLLLASLALLHLV 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489316433 124 VGLSEAPSFPGNGRVVASwfpsSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGAAGILLAVI 196
Cdd:cd17485 316 GGMITTALFTLMMDCSQQ----AQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLL 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
1-198 |
3.74e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 1 MKKDYANVSPADKKTSVRWFIVFMLFLVTSINYADRATLSITgdsVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLD 80
Cdd:cd17473 182 SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 81 RFGSKTVIALSIFFWsfftllqgAIGFFSAGTA--IILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSA 158
Cdd:cd17473 259 RLGKRRLLAIGFALM--------ALGFLLLALAsgLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA 330
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 489316433 159 QYFAIVIFSPLMGWLTHSFGWHS-VFVVMGAAGILLAVIWL 198
Cdd:cd17473 331 FFLGQFLSPLVLGPLVNLTGGLSgAFLILGVLALVLAIVLL 371
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
17-209 |
5.33e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 38.82 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 17 VRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDS--VAM----GYVfsafgwAYVIGQLPGGWLLDRFGSKTVIAL 90
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDsdIALlanwGPI------GFVPTFFFMAWLMDVKGLRIAVLS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 91 SiffwSFFTLLQGAIGFFSA--GTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIV---I 165
Cdd:cd17397 75 S----AFLVAAGTGLRCIPVpnHLATWLIHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAasfL 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 489316433 166 FSPLMgWLTHSFGWhsvfvvmgAAGILLAVIwlktVYEPKKHPK 209
Cdd:cd17397 151 IGPLV-LMYLEFGW--------SALIFLAML----IYFPSKPPT 181
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
48-199 |
7.41e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.35 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTVI--ALSIFFwsfftllqgaIGFFSAGTA--IILLFALRFL 123
Cdd:PRK11652 36 RDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVIlvGMSIFI----------LGTLVALFAhsLTVLIAASAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 124 VGLSEapsfpGNGRVVASWFPSSE-RGTASAFFNSAQYFAIvIFSPLM-----GWLTHSFGWHSVFV---VMGAAGILLA 194
Cdd:PRK11652 106 QGLGT-----GVGGVMARTLPRDLyEGTQLRHANSLLNMGI-LVSPLLapligGLLTTLFGWRACYLfllLLGAGVTFSM 179
|
....*
gi 489316433 195 VIWLK 199
Cdd:PRK11652 180 ARWMP 184
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
255-428 |
7.93e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 255 VYIAQYCITTLTYFFLTwFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRSLTfarkapIIVGMLL 334
Cdd:cd17370 204 LYLLAVALFALGNFSFA-FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD---RIGRKKL------LILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489316433 335 S-CSMVVCNYTDSAWLVVVIMslAFFGKGFGA---LGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNaTG 410
Cdd:cd17370 274 LaLAYLGFALGSSLWLLLLGF--ILWGLYMGAqesIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD-LI 350
|
170
....*....|....*...
gi 489316433 411 SFNGALVFVGANAIAAIL 428
Cdd:cd17370 351 SPSAAFLFSAVLALIALL 368
|
|
| |
