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Conserved domains on  [gi|489701683|ref|WP_003605820|]
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class I SAM-dependent methyltransferase [Lacticaseibacillus paracasei]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11457987)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Methanocaldococcus jannaschii S-adenosylmethionine-dependent methyltransferase MJ0882

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 8-198 8.26e-70

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 210.43  E-value: 8.26e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   8 DPDLAHDEHSFDFELGGHSLRFTSDNGVFSKHTVDFGSRVLIATIlaEELPAGPILDVGTGYGPIGLALAKHFPDRQVTM 87
Cdd:COG2813    1 APAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHL--PEPLGGRVLDLGCGYGVIGLALAKRNPEARVTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  88 SDVNERALALAQRNATDNAISNVTIVESSMYDQI-DGQFGVIVTNPPIRAG----KTIVSGILAGAAEHLLPHGQLYAVI 162
Cdd:COG2813   79 VDVNARAVELARANAAANGLENVEVLWSDGLSGVpDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWLVA 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 489701683 163 QKKQgapSALKLMKTIYPDASIVKKEHGYYILKATK 198
Cdd:COG2813  159 NRHL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 8-198 8.26e-70

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 210.43  E-value: 8.26e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   8 DPDLAHDEHSFDFELGGHSLRFTSDNGVFSKHTVDFGSRVLIATIlaEELPAGPILDVGTGYGPIGLALAKHFPDRQVTM 87
Cdd:COG2813    1 APAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHL--PEPLGGRVLDLGCGYGVIGLALAKRNPEARVTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  88 SDVNERALALAQRNATDNAISNVTIVESSMYDQI-DGQFGVIVTNPPIRAG----KTIVSGILAGAAEHLLPHGQLYAVI 162
Cdd:COG2813   79 VDVNARAVELARANAAANGLENVEVLWSDGLSGVpDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWLVA 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 489701683 163 QKKQgapSALKLMKTIYPDASIVKKEHGYYILKATK 198
Cdd:COG2813  159 NRHL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 27-195 1.23e-54

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 171.23  E-value: 1.23e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   27 LRFTSDNGVFSKHTVDFGSRVLIATIlaEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNA 106
Cdd:pfam05175   2 LTFKTLPGVFSHGRLDIGSRLLLEHL--PKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  107 ISNVTIVESSMYDQI-DGQFGVIVTNPPIRAGK----TIVSGILAGAAEHLLPHGQLYAVIQKKQGAPSalkLMKTIYPD 181
Cdd:pfam05175  80 LENGEVVASDVYSGVeDGKFDLIISNPPFHAGLattyNVAQRFIADAKRHLRPGGELWIVANRFLGYPP---LLEELFGN 156

                         170
                  ....*....|....
gi 489701683  182 ASIVKKEHGYYILK 195
Cdd:pfam05175 157 VEVVAKTNGFKVLK 170
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 47-159 9.77e-24

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 94.84  E-value: 9.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  47 VLIATILAEELPAGP--ILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYDQI-DG 123
Cdd:PRK09328  95 ELVEWALEALLLKEPlrVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLpGG 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489701683 124 QFGVIVTNPP-IRAGKTI---------------VSG---------ILAGAAEHLLPHGQLY 159
Cdd:PRK09328 175 RFDLIVSNPPyIPEADIHllqpevrdhephlalFGGedgldfyrrIIEQAPRYLKPGGWLL 235
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 53-133 1.09e-15

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 73.16  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   53 LAEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAIS-NVTIVESSMYDQIDG-QFGVIVT 130
Cdd:TIGR00536 109 LISQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEhRVEFIQSNLFEPLAGqKIDIIVS 188


                  ...
gi 489701683  131 NPP 133
Cdd:TIGR00536 189 NPP 191
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 62-162 1.82e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.60  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  62 ILDVGTGYGPIGLALAKHfPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYD---QIDGQFGVIVTNPPIRAGK 138
Cdd:cd02440    2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEElppEADESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 489701683 139 TIVSGILAGAAEHLLPHGQLYAVI 162
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 8-198 8.26e-70

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 210.43  E-value: 8.26e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   8 DPDLAHDEHSFDFELGGHSLRFTSDNGVFSKHTVDFGSRVLIATIlaEELPAGPILDVGTGYGPIGLALAKHFPDRQVTM 87
Cdd:COG2813    1 APAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHL--PEPLGGRVLDLGCGYGVIGLALAKRNPEARVTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  88 SDVNERALALAQRNATDNAISNVTIVESSMYDQI-DGQFGVIVTNPPIRAG----KTIVSGILAGAAEHLLPHGQLYAVI 162
Cdd:COG2813   79 VDVNARAVELARANAAANGLENVEVLWSDGLSGVpDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWLVA 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 489701683 163 QKKQgapSALKLMKTIYPDASIVKKEHGYYILKATK 198
Cdd:COG2813  159 NRHL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 27-195 1.23e-54

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 171.23  E-value: 1.23e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   27 LRFTSDNGVFSKHTVDFGSRVLIATIlaEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNA 106
Cdd:pfam05175   2 LTFKTLPGVFSHGRLDIGSRLLLEHL--PKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  107 ISNVTIVESSMYDQI-DGQFGVIVTNPPIRAGK----TIVSGILAGAAEHLLPHGQLYAVIQKKQGAPSalkLMKTIYPD 181
Cdd:pfam05175  80 LENGEVVASDVYSGVeDGKFDLIISNPPFHAGLattyNVAQRFIADAKRHLRPGGELWIVANRFLGYPP---LLEELFGN 156

                         170
                  ....*....|....
gi 489701683  182 ASIVKKEHGYYILK 195
Cdd:pfam05175 157 VEVVAKTNGFKVLK 170
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 47-159 9.77e-24

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 94.84  E-value: 9.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  47 VLIATILAEELPAGP--ILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYDQI-DG 123
Cdd:PRK09328  95 ELVEWALEALLLKEPlrVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLpGG 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489701683 124 QFGVIVTNPP-IRAGKTI---------------VSG---------ILAGAAEHLLPHGQLY 159
Cdd:PRK09328 175 RFDLIVSNPPyIPEADIHllqpevrdhephlalFGGedgldfyrrIIEQAPRYLKPGGWLL 235
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 47-159 4.98e-23

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 92.91  E-value: 4.98e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  47 VLIATILaEELPAGP---ILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISN-VTIVESSMYDQI- 121
Cdd:COG2890   99 ELVELAL-ALLPAGApprVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPLp 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489701683 122 -DGQFGVIVTNPP-IRAG--KTI-------------VSG---------ILAGAAEHLLPHGQLY 159
Cdd:COG2890  178 gDGRFDLIVSNPPyIPEDeiALLppevrdheprlalDGGedgldfyrrIIAQAPRLLKPGGWLL 241
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
34-161 3.69e-21

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 88.84  E-value: 3.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  34 GVFSKHTVDFGSRVLIATIlaEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNvTIV 113
Cdd:PRK09489 174 GVFSRDGLDVGSQLLLSTL--TPHTKGKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEG-EVF 250

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489701683 114 ESSMYDQIDGQFGVIVTNPP----IRAGKTIVSGILAGAAEHLLPHGQLYAV 161
Cdd:PRK09489 251 ASNVFSDIKGRFDMIISNPPfhdgIQTSLDAAQTLIRGAVRHLNSGGELRIV 302
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 53-133 1.09e-15

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 73.16  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   53 LAEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAIS-NVTIVESSMYDQIDG-QFGVIVT 130
Cdd:TIGR00536 109 LISQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEhRVEFIQSNLFEPLAGqKIDIIVS 188


                  ...
gi 489701683  131 NPP 133
Cdd:TIGR00536 189 NPP 191
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 58-162 6.41e-14

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 67.86  E-value: 6.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  58 PAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISN-VTIVESSMYDQ----IDGQFGVIVTNP 132
Cdd:COG4123   37 KGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFaaelPPGSFDLVVSNP 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489701683 133 PIR-AGKTIVSG-----------------ILAGAAEHLLPHGQLYAVI 162
Cdd:COG4123  117 PYFkAGSGRKSPdearaiarhedaltledLIRAAARLLKPGGRFALIH 164
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 62-162 1.82e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.60  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  62 ILDVGTGYGPIGLALAKHfPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYD---QIDGQFGVIVTNPPIRAGK 138
Cdd:cd02440    2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEElppEADESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 489701683 139 TIVSGILAGAAEHLLPHGQLYAVI 162
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLTL 104
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 21-137 2.03e-12

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 64.81  E-value: 2.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  21 ELGGHSLRFTSDngvfskhtvDF------GSRVLIATIL--AEELPAGPILDVGTGYGPIGLALAKHFpdRQVTMSDVNE 92
Cdd:COG2265  197 RLGGLTFRISPG---------SFfqvnpeQAEALYAAALewLDLTGGERVLDLYCGVGTFALPLARRA--KKVIGVEIVP 265

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489701683  93 RALALAQRNATDNAISNVTIVESSMYDQI-----DGQFGVIVTNPPiRAG 137
Cdd:COG2265  266 EAVEDARENARLNGLKNVEFVAGDLEEVLpellwGGRPDVVVLDPP-RAG 314
PRK14968 PRK14968
putative methyltransferase; Provisional
 48-189 2.91e-11

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 59.53  E-value: 2.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  48 LIATILAEElPAGPILDVGTGYGPIGLALAKHfpDRQVTMSDVNERALALAQRNATDNAISN--VTIVESSMYDQIDG-Q 124
Cdd:PRK14968  14 LLAENAVDK-KGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDLFEPFRGdK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683 125 FGVIVTNPPI--------------------RAGKTIVSGILAGAAEHLLPHGQLYAVIQKKQGAPSALKLMKTIYPDASI 184
Cdd:PRK14968  91 FDVILFNPPYlpteeeeewddwlnyalsggKDGREVIDRFLDEVGRYLKPGGRILLLQSSLTGEDEVLEYLEKLGFEAEV 170


                 ....*
gi 489701683 185 VKKEH 189
Cdd:PRK14968 171 VAEEK 175
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
7-198 3.78e-10

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 58.11  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   7 NDPDLAHDEHSFDFELGGHSLRFTSDNGVFSKHTVDFGSRVLIatilaEELPA---GPILDVGTGYGPIGLALAKHFPDR 83
Cdd:PRK15001 179 NEPPLADAPQTVSWKLEGTDWTIHNHANVFSRTGLDIGARFFM-----QHLPEnleGEIVDLGCGNGVIGLTLLDKNPQA 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  84 QVTMSDVNERALALAQRNATDNAISNVTIVESSMYDQIDG----QFGVIVTNPPIRAGKTIVSGILAGAAEH----LLPH 155
Cdd:PRK15001 254 KVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALSGvepfRFNAVLCNPPFHQQHALTDNVAWEMFHHarrcLKIN 333

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 489701683 156 GQLYAVIQKKQgapSALKLMKTIYPDASIVKKEHGYYILKATK 198
Cdd:PRK15001 334 GELYIVANRHL---DYFHKLKKIFGNCTTIATNNKFVVLKAVK 373
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-166 6.31e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.08  E-value: 6.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  47 VLIATILAEELPAG-PILDVGTGYGPIGLALAKHFpDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYDQI---D 122
Cdd:COG0500   14 LAALLALLERLPKGgRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDplpA 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489701683 123 GQFGVIV-------TNPPIRagktivSGILAGAAEHLLPHGQLYAVIQKKQ 166
Cdd:COG0500   93 ESFDLVVafgvlhhLPPEER------EALLRELARALKPGGVLLLSASDAA 137
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 62-131 1.49e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 52.95  E-value: 1.49e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489701683   62 ILDVGTGYGPIGLALAKHFpDRQVTMSDVNERALALAQRNATDNAIsNVTIVESSM--YDQIDGQFGVIVTN 131
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAedLPFPDGSFDLVVSS 70
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-159 8.29e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.56  E-value: 8.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  49 IATILAEELPAGP-ILDVGTGYGPIGLALAKHFpdRQVTMSDVNERALALAQRNATDnaiSNVTIVESSMYD--QIDGQF 125
Cdd:COG2227   14 LAALLARLLPAGGrVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIARERAAE---LNVDFVQGDLEDlpLEDGSF 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489701683 126 GVIVTN------PPIRAgktivsgILAGAAEHLLPHGQLY 159
Cdd:COG2227   89 DLVICSevlehlPDPAA-------LLRELARLLKPGGLLL 121
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 62-133 2.06e-07

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 50.25  E-value: 2.06e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489701683  62 ILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISN-VTIVESSMYDQIDGQ-FGVIVTNPP 133
Cdd:PRK01544 142 ILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDrIQIIHSNWFENIEKQkFDFIVSNPP 215
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 48-133 5.29e-07

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 48.92  E-value: 5.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  48 LIATILAEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAiSNVTIVESSMYDQ---IDGQ 124
Cdd:PRK14966 241 LVEAVLARLPENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLG-ARVEFAHGSWFDTdmpSEGK 319


                 ....*....
gi 489701683 125 FGVIVTNPP 133
Cdd:PRK14966 320 WDIIVSNPP 328
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 53-131 9.07e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.83  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  53 LAEELPAGP---ILDVGTGYGPIGLALAKHfpDRQVTMSDVNERALALAQRNATDNAIsNVTIVESSMYDQ--IDGQFGV 127
Cdd:COG2226   14 LLAALGLRPgarVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLpfPDGSFDL 90


                 ....
gi 489701683 128 IVTN 131
Cdd:COG2226   91 VISS 94
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-131 1.93e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.79  E-value: 1.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489701683   58 PAGPILDVGTGYGPIGLALA-KHFPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYD----QIDGQFGVIVTN 131
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAeELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEElpelLEDDKFDVVISN 81
PRK14967 PRK14967
putative methyltransferase; Provisional
 45-133 2.05e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 43.50  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  45 SRVLIATILAEELPAGP-ILDVGTGYGPIGLAlAKHFPDRQVTMSDVNERALALAQRNATDNAIsNVTIVESSMYDQIDG 123
Cdd:PRK14967  22 TQLLADALAAEGLGPGRrVLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLNALLAGV-DVDVRRGDWARAVEF 99

                         90
                 ....*....|.
gi 489701683 124 Q-FGVIVTNPP 133
Cdd:PRK14967 100 RpFDVVVSNPP 110
tdh PRK05396
L-threonine 3-dehydrogenase; Validated
 67-111 8.03e-05

L-threonine 3-dehydrogenase; Validated


Pssm-ID: 180054 [Multi-domain]  Cd Length: 341  Bit Score: 42.12  E-value: 8.03e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489701683  67 TGYGPIGL---ALAKHFPDRQVTMSDVNERALALAQRNATDNAIsNVT 111
Cdd:PRK05396 170 TGAGPIGImaaAVAKHVGARHVVITDVNEYRLELARKMGATRAV-NVA 216
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
49-109 8.86e-05

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 41.87  E-value: 8.86e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489701683  49 IATILAEeLPAGP--ILDVGTGYGPIGLALAK--HfpdrQVTMSDVNERALALAQRNATDNAISN 109
Cdd:PRK11036  34 LDRLLAE-LPPRPlrVLDAGGGEGQTAIKLAElgH----QVILCDLSAEMIQRAKQAAEAKGVSD 93
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 29-114 1.62e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 41.31  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  29 FTSDNGVFSKHTVdfgsRVLIatiLAE-ELPAGPIL-DVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNA 106
Cdd:COG2242  223 FERDKGPITKREV----RALT---LAKlALRPGDVLwDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFG 295


                 ....*...
gi 489701683 107 ISNVTIVE 114
Cdd:COG2242  296 VPNVEVVE 303
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
62-114 1.91e-04

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 40.37  E-value: 1.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489701683  62 ILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNVTIVE 114
Cdd:PRK08287  35 LIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDIIP 87
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
48-167 1.95e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.37  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  48 LIATILAE--ELPAGPILDVGTGYGPIGLALAKHFpdRQVTMSDVNERALALAQRNATDNAISNVTIVEssmYDQIDGQF 125
Cdd:COG4976   34 LAEELLARlpPGPFGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREKGVYDRLLVADLAD---LAEPDGRF 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 489701683 126 GVIVTN---PPIRAGKTivsgILAGAAEHLLPHGQLYAVIQKKQG 167
Cdd:COG4976  109 DLIVAAdvlTYLGDLAA----VFAGVARALKPGGLFIFSVEDADG 149
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
53-153 3.08e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 40.54  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  53 LAEELPAGP-ILDVGTGYGpIgLA-LAKHFPDRQVTMSDVNERALALAQRNATDNAISN-VTIVESSMYDqiDGQFGVIV 129
Cdd:COG2264  142 LEKLLKPGKtVLDVGCGSG-I-LAiAAAKLGAKRVLAVDIDPVAVEAARENAELNGVEDrIEVVLGDLLE--DGPYDLVV 217

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489701683 130 TN----------PPIRA-----GKTIVSGILAGAAEHLL 153
Cdd:COG2264  218 ANilanplielaPDLAAllkpgGYLILSGILEEQADEVL 256
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-131 4.82e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.12  E-value: 4.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489701683   63 LDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRN---ATDNAISNVTIVESSMYDQIDGQFGVIVTN 131
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaaLGLLNAVRVELFQLDLGELDPGSFDVVVAS 72
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 62-114 4.91e-04

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 39.24  E-value: 4.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489701683   62 ILDVGTGYGPIGLALAKHFPDRQVTMSDVNErALALAQRNATDNAISNVTIVE 114
Cdd:pfam10294  50 VLELGSGTGLVGIAVALLLPGASVTITDLEE-ALELLKKNIELNALSSKVVVK 101
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
45-133 5.81e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 39.12  E-value: 5.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  45 SRVLIATILAEELPAGPILDVGTGYGPIGLAlAKHFPDRQVTMSDVNERALALAQRNAtDNAISNVTIVESSMYD-QIDG 123
Cdd:COG2263   32 AELLHLAYLRGDIEGKTVLDLGCGTGMLAIG-AALLGAKKVVGVDIDPEALEIARENA-ERLGVRVDFIRADVTRiPLGG 109

                         90
                 ....*....|
gi 489701683 124 QFGVIVTNPP 133
Cdd:COG2263  110 SVDTVVMNPP 119
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 53-129 6.19e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.76  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  53 LAEELPAGP---ILDVGTGYGPIGLALAKHFpDRQVTMSDVNERALALAQRNATDNAISN-VTIVESSMYD-QIDGQFGV 127
Cdd:COG2230   43 ILRKLGLKPgmrVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDlPADGQFDA 121


                 ..
gi 489701683 128 IV 129
Cdd:COG2230  122 IV 123
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 62-150 6.38e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.56  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   62 ILDVGTGYGPIGLALAKHFPDRqVTMSDVNERALALAQRNATDNAISNVTIVESSMyDQIDGQFGVIVTN---PPIRA-- 136
Cdd:pfam06325 165 VLDVGCGSGILAIAALKLGAKK-VVGVDIDPVAVRAAKENAELNGVEARLEVYLPG-DLPKEKADVVVANilaDPLIEla 242

                          90       100
                  ....*....|....*....|....
gi 489701683  137 ----------GKTIVSGILAGAAE 150
Cdd:pfam06325 243 pdiyalvkpgGYLILSGILKEQAQ 266
PRK06202 PRK06202
hypothetical protein; Provisional
 44-131 7.99e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 38.83  E-value: 7.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  44 GSRVLIATILAEEL-PAGP--ILDVGTGYGPIGLALAkHFPDRQ-----VTMSDVNERALALAQRNATDNAiSNVTIVES 115
Cdd:PRK06202  43 GWRGLYRRLLRPALsADRPltLLDIGCGGGDLAIDLA-RWARRDglrleVTAIDPDPRAVAFARANPRRPG-VTFRQAVS 120

                         90
                 ....*....|....*.
gi 489701683 116 SMYDQIDGQFGVIVTN 131
Cdd:PRK06202 121 DELVAEGERFDVVTSN 136
TDH cd05281
Threonine dehydrogenase; L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent ...
 51-115 1.10e-03

Threonine dehydrogenase; L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine via NAD(H)- dependent oxidation. THD is a member of the zinc-requiring, medium chain NAD(H)-dependent alcohol dehydrogenase family (MDR). MDRs have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria) and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose.


Pssm-ID: 176184 [Multi-domain]  Cd Length: 341  Bit Score: 38.75  E-value: 1.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489701683  51 TILAEELPAGPILDvgTGYGPIGL---ALAKHFPDRQVTMSDVNERALALAQRNATDNAIS----NVTIVES 115
Cdd:cd05281  156 TVLAGDVSGKSVLI--TGCGPIGLmaiAVAKAAGASLVIASDPNPYRLELAKKMGADVVINpreeDVVEVKS 225
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 47-113 1.48e-03

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 38.74  E-value: 1.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489701683  47 VLIATILAEELPAGPILDVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNVTIV 113
Cdd:PRK04338  46 VLVLRAFGPKLPRESVLDALSASGIRGIRYALETGVEKVTLNDINPDAVELIKKNLELNGLENEKVF 112
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 60-137 1.49e-03

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 38.57  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683   60 GPILDVGTGYGPIGLALAKHFpdRQVTMSDVNERALALAQRNATDNAISNVTIVESSM------------------YDQI 121
Cdd:pfam05958 203 GDLLELYCGNGNFSLALARNF--RKVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAeeftqamngvrefnrlkgIDLK 280

                          90
                  ....*....|....*.
gi 489701683  122 DGQFGVIVTNPPiRAG 137
Cdd:pfam05958 281 SYNCSTIFVDPP-RAG 295
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 53-162 2.71e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 36.85  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  53 LAEELPAGPILD--VGTGygpiGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYD--QIDGQFGVI 128
Cdd:COG1041   21 LAGAKEGDTVLDpfCGTG----TILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDlpLADESVDAI 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489701683 129 VTNPP------IRAG--KTIVSGILAGAAEHLLPHGqlYAVI 162
Cdd:COG1041   97 VTDPPygrsskISGEelLELYEKALEEAARVLKPGG--RVVI 136
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-131 4.57e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 34.95  E-value: 4.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489701683   63 LDVGTGYGPIGLALAKHFPdrQVTMSDVNERALALAQRNATDNaisNVTIVESSMYDQ--IDGQFGVIVTN 131
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAPRE---GLTFVVGDAEDLpfPDNSFDLVLSS 66
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 30-180 4.97e-03

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 36.67  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  30 TSDNGVFSKHTVDfgSRVLIATIlaeELPAGPILDVGTGYG-PiGLALAKHFPDRQVTMSDVNE-RALALaqRNATDN-A 106
Cdd:COG0357   44 RDPEELWERHILD--SLALLPLL---PKEGARVLDVGSGAGfP-GIPLAIARPDLQVTLVDSLGkKIAFL--REVVRElG 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683 107 ISNVTI----VESSmydQIDGQFGVIVTnppiRAgktiVS--GILAGAAEHLL-PHGQLYA-----VIQKKQGAPSALKL 174
Cdd:COG0357  116 LKNVTVvhgrAEEL---APREKFDVVTA----RA----VAplPDLLELALPLLkPGGRLLAlkgpdAEEELAEAPKALKV 184


                 ....*.
gi 489701683 175 MKTIYP 180
Cdd:COG0357  185 LEEVEE 190
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
64-161 5.12e-03

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 36.51  E-value: 5.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489701683  64 DVGTGYGPIGLALAKHFPDRQVTMSDVNERALALAQRNATDNAISNVTIVESSMYDQIDGqfgvIVTNPP---IRAGKTI 140
Cdd:PRK07402  46 DIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIEGSAPECLAQ----LAPAPDrvcIEGGRPI 121

                         90       100
                 ....*....|....*....|.
gi 489701683 141 vSGILAGAAEHLLPHGQLYAV 161
Cdd:PRK07402 122 -KEILQAVWQYLKPGGRLVAT 141
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 75-133 5.55e-03

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 36.62  E-value: 5.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489701683  75 ALAKHFPDRQVTM--SDVNERALALAQRNAT----DNAIsnvTIVESSMYD-QIDGQFGVIVTNPP 133
Cdd:COG0116  241 AEARIKRDPPLPIfgSDIDPRAIEAARENAEragvADLI---EFEQADFRDlEPPAEPGLIITNPP 303
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
62-130 7.89e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 36.17  E-value: 7.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489701683  62 ILDVGTGYGPIGLALAKHFPdRQVTMSDVNERALALAQRNATDNAIS-NVTIVE--SSMYDqIDGQFGVIVT 130
Cdd:COG4076   39 VLDIGTGSGLLSMLAARAGA-KKVYAVEVNPDIAAVARRIIAANGLSdRITVINadATDLD-LPEKADVIIS 108
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 62-114 9.44e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 35.99  E-value: 9.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489701683  62 ILDVGTGYGPIGLALAKHFPdRQVTMSDVNERALALAQRNATDNAIS-NVTIVE 114
Cdd:COG2520  184 VLDMFAGVGPFSIPIAKRSG-AKVVAIDINPDAVEYLKENIRLNKVEdRVTPIL 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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