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Conserved domains on  [gi|489737744|ref|WP_003641839|]
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MULTISPECIES: nicotinamide riboside transporter PnuC [Lactiplantibacillus]

Protein Classification

nicotinamide mononucleotide transporter family protein( domain architecture ID 10523161)

nicotinamide mononucleotide transporter family protein such as nicotinamide riboside transporter PnuC, which is involved in the transport of nicotinamide ribonucleoside across the inner membrane, and riboflavin/roseoflavin transporter RibM

Gene Ontology:  GO:0034257|GO:0005886
PubMed:  22136195|2546921
TCDB:  4.B.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NMN_transporter pfam04973
Nicotinamide mononucleotide transporter; Members of this family are integral membrane proteins ...
45-223 3.06e-29

Nicotinamide mononucleotide transporter; Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.


:

Pssm-ID: 428230  Cd Length: 176  Bit Score: 108.78  E-value: 3.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744   45 SILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLAYVVtLDIPVLLsaNWNVNMVSKIRKF 124
Cdd:pfam04973   1 SWLELIAALLGLLCVWLAARGNIWNWPVGIISVLLYAYLFFQAGLYGDMGLQLYYFV-MSIYGWY--LWLRGRDQPVRRL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  125 TGKTWIVAIVATLVVYAISGYLIGALTDDPRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWFIsfrqgSA 204
Cdd:pfam04973  78 TRKEWLLLLLATVVGTALLGYLLSAFTDAAVPYLDAFTTVLSIVAQWLMARRYVENWLLWIVVDIVSVPLYFY-----KG 152
                         170
                  ....*....|....*....
gi 489737744  205 TLAMFINSSVYLMNDVLAF 223
Cdd:pfam04973 153 LYLTALLYVIYLINAIYGY 171
 
Name Accession Description Interval E-value
NMN_transporter pfam04973
Nicotinamide mononucleotide transporter; Members of this family are integral membrane proteins ...
45-223 3.06e-29

Nicotinamide mononucleotide transporter; Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.


Pssm-ID: 428230  Cd Length: 176  Bit Score: 108.78  E-value: 3.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744   45 SILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLAYVVtLDIPVLLsaNWNVNMVSKIRKF 124
Cdd:pfam04973   1 SWLELIAALLGLLCVWLAARGNIWNWPVGIISVLLYAYLFFQAGLYGDMGLQLYYFV-MSIYGWY--LWLRGRDQPVRRL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  125 TGKTWIVAIVATLVVYAISGYLIGALTDDPRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWFIsfrqgSA 204
Cdd:pfam04973  78 TRKEWLLLLLATVVGTALLGYLLSAFTDAAVPYLDAFTTVLSIVAQWLMARRYVENWLLWIVVDIVSVPLYFY-----KG 152
                         170
                  ....*....|....*....
gi 489737744  205 TLAMFINSSVYLMNDVLAF 223
Cdd:pfam04973 153 LYLTALLYVIYLINAIYGY 171
PnuC COG3201
Nicotinamide riboside transporter PnuC [Coenzyme transport and metabolism];
41-236 2.65e-27

Nicotinamide riboside transporter PnuC [Coenzyme transport and metabolism];


Pssm-ID: 442434  Cd Length: 203  Bit Score: 104.18  E-value: 2.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  41 ITALSILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLAYVVTLdipVLLSANWNVNMVS- 119
Cdd:COG3201   13 GTPMSWLELIAVLFGLLSVWLAARRNIWNWPFGIISTLLYAYLFFQAKLYGDALLQVYYFIMS---IYGWYQWKRGRDNe 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744 120 ---KIRKFTGKTWIVAIVATLVVYAISGYLIGALTDDPRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWF 196
Cdd:COG3201   90 gevPVRRLSLKEWLLLIAAGVLGTLLLGYLLKAFTDSAVPYLDAFTTVLSLVAQWLMARKYVENWLLWIVVDIVSVPLYF 169
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489737744 197 IsfrqgSATLAMFINSSVYLMNDVLAFTVspWYNKHERAR 236
Cdd:COG3201  170 Y-----KGLYLTAILYAVFLVLAIYGYRN--WRKSAKQQK 202
NMN_trans_PnuC TIGR01528
nicotinamide mononucleotide transporter PnuC; The PnuC protein of E. coli is membrane protein ...
44-230 5.82e-14

nicotinamide mononucleotide transporter PnuC; The PnuC protein of E. coli is membrane protein responsible for nicotinamide mononucleotide transport, subject to regulation by interaction with the NadR (also called NadI) protein (see TIGR01526). This model defines a region corresponding to most of the length of PnuC, found primarily in pathogens. The extreme N- and C-terminal regions are poorly conserved and not included in the alignment and model. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273672  Cd Length: 189  Bit Score: 68.21  E-value: 5.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744   44 LSILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLaYVVTLDIPVLL-----SANWNVNMV 118
Cdd:TIGR01528   1 LSIIELIAGLMGILCVVLASEGKVSNYIFGLISAVIYLYIAYQTGLYAEVLLQL-FFVIANIYGLFawkknSQQEENGVT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  119 SKIRKFTGKTWIVAIVATLVVYAISGYLIGALTDDpRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWfis 198
Cdd:TIGR01528  80 SGLKKLKGKGWTIILSTSVVLTVVIALILKFIGDN-FPWLDSITFVIGIVAQILMVRRYRENWILWLLSNVVSIILW--- 155
                         170       180       190
                  ....*....|....*....|....*....|..
gi 489737744  199 FRQGSATLAMFINSSVYLMNDVLAFtvSPWYN 230
Cdd:TIGR01528 156 FLAFTGSLAMLLTYIIYLFNSLYGF--YNWNK 185
 
Name Accession Description Interval E-value
NMN_transporter pfam04973
Nicotinamide mononucleotide transporter; Members of this family are integral membrane proteins ...
45-223 3.06e-29

Nicotinamide mononucleotide transporter; Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.


Pssm-ID: 428230  Cd Length: 176  Bit Score: 108.78  E-value: 3.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744   45 SILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLAYVVtLDIPVLLsaNWNVNMVSKIRKF 124
Cdd:pfam04973   1 SWLELIAALLGLLCVWLAARGNIWNWPVGIISVLLYAYLFFQAGLYGDMGLQLYYFV-MSIYGWY--LWLRGRDQPVRRL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  125 TGKTWIVAIVATLVVYAISGYLIGALTDDPRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWFIsfrqgSA 204
Cdd:pfam04973  78 TRKEWLLLLLATVVGTALLGYLLSAFTDAAVPYLDAFTTVLSIVAQWLMARRYVENWLLWIVVDIVSVPLYFY-----KG 152
                         170
                  ....*....|....*....
gi 489737744  205 TLAMFINSSVYLMNDVLAF 223
Cdd:pfam04973 153 LYLTALLYVIYLINAIYGY 171
PnuC COG3201
Nicotinamide riboside transporter PnuC [Coenzyme transport and metabolism];
41-236 2.65e-27

Nicotinamide riboside transporter PnuC [Coenzyme transport and metabolism];


Pssm-ID: 442434  Cd Length: 203  Bit Score: 104.18  E-value: 2.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  41 ITALSILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLAYVVTLdipVLLSANWNVNMVS- 119
Cdd:COG3201   13 GTPMSWLELIAVLFGLLSVWLAARRNIWNWPFGIISTLLYAYLFFQAKLYGDALLQVYYFIMS---IYGWYQWKRGRDNe 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744 120 ---KIRKFTGKTWIVAIVATLVVYAISGYLIGALTDDPRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWF 196
Cdd:COG3201   90 gevPVRRLSLKEWLLLIAAGVLGTLLLGYLLKAFTDSAVPYLDAFTTVLSLVAQWLMARKYVENWLLWIVVDIVSVPLYF 169
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489737744 197 IsfrqgSATLAMFINSSVYLMNDVLAFTVspWYNKHERAR 236
Cdd:COG3201  170 Y-----KGLYLTAILYAVFLVLAIYGYRN--WRKSAKQQK 202
NMN_trans_PnuC TIGR01528
nicotinamide mononucleotide transporter PnuC; The PnuC protein of E. coli is membrane protein ...
44-230 5.82e-14

nicotinamide mononucleotide transporter PnuC; The PnuC protein of E. coli is membrane protein responsible for nicotinamide mononucleotide transport, subject to regulation by interaction with the NadR (also called NadI) protein (see TIGR01526). This model defines a region corresponding to most of the length of PnuC, found primarily in pathogens. The extreme N- and C-terminal regions are poorly conserved and not included in the alignment and model. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273672  Cd Length: 189  Bit Score: 68.21  E-value: 5.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744   44 LSILTFIGTTLGVLCVLAINAAKSVNGLLGVISAACFIVVGFSAKNYLSIGEQLaYVVTLDIPVLL-----SANWNVNMV 118
Cdd:TIGR01528   1 LSIIELIAGLMGILCVVLASEGKVSNYIFGLISAVIYLYIAYQTGLYAEVLLQL-FFVIANIYGLFawkknSQQEENGVT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737744  119 SKIRKFTGKTWIVAIVATLVVYAISGYLIGALTDDpRPWVDAISFAICLTAGVICFLRYNNQYFWWIASGLAQMVLWfis 198
Cdd:TIGR01528  80 SGLKKLKGKGWTIILSTSVVLTVVIALILKFIGDN-FPWLDSITFVIGIVAQILMVRRYRENWILWLLSNVVSIILW--- 155
                         170       180       190
                  ....*....|....*....|....*....|..
gi 489737744  199 FRQGSATLAMFINSSVYLMNDVLAFtvSPWYN 230
Cdd:TIGR01528 156 FLAFTGSLAMLLTYIIYLFNSLYGF--YNWNK 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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