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Conserved domains on  [gi|489770573|ref|WP_003674484|]
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MULTISPECIES: cyclic pyranopterin monophosphate synthase MoaC [Limosilactobacillus]

Protein Classification

cyclic pyranopterin monophosphate synthase MoaC( domain architecture ID 10013201)

cyclic pyranopterin monophosphate synthase MoaC catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP), as part of the molybdenum cofactor biosynthesis

CATH:  3.30.70.640
EC:  4.6.1.17
Gene Symbol:  moaC
PubMed:  25941396
SCOP:  4001279

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
3-158 4.53e-89

cyclic pyranopterin monophosphate synthase MoaC;


:

Pssm-ID: 236483  Cd Length: 159  Bit Score: 256.66  E-value: 4.53e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   3 DKLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPL 82
Cdd:PRK09364   2 SQLTHINEQGRAKMVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLML 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489770573  83 TGVDIHFHNNGQ-DTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGHFIFD 158
Cdd:PRK09364  82 TGVDVDFEWDPElPGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKSGDFKRE 158
 
Name Accession Description Interval E-value
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
3-158 4.53e-89

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 256.66  E-value: 4.53e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   3 DKLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPL 82
Cdd:PRK09364   2 SQLTHINEQGRAKMVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLML 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489770573  83 TGVDIHFHNNGQ-DTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGHFIFD 158
Cdd:PRK09364  82 TGVDVDFEWDPElPGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKSGDFKRE 158
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
2-153 1.92e-88

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 254.98  E-value: 1.92e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   2 TDKLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIP 81
Cdd:COG0315    1 MSELTHLDEQGRARMVDVSDKAVTARTAVAEGRVRMSPETLALIREGGVKKGDVLAVARIAGIMAAKRTSELIPLCHPLP 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489770573  82 LTGVDIHFH-NNGQDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSG 153
Cdd:COG0315   81 LTGVDVDFElDDDLSGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIEDIRLLEKSGGKSG 153
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
16-150 6.03e-78

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 227.61  E-value: 6.03e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   16 MVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHFH-NNGQ 94
Cdd:pfam01967   1 MVDVSDKPVTLRTAVAEGRIRLSPETLELIREGTVKKGDVLAVARIAGIMAAKKTSDLIPLCHPLPLTGVDVEFElDEEE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489770573   95 DTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGG 150
Cdd:pfam01967  81 DGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDIRLLEKSGG 136
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
16-154 6.25e-76

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 222.81  E-value: 6.25e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  16 MVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHFHNNGQD 95
Cdd:cd01420    1 MVDVSDKAVTERTAVAEGRVRMSPETLDLITEGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDEET 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  96 -TITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGH 154
Cdd:cd01420   81 sGVRIEATVRTTGRTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGKSGD 140
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
5-152 3.45e-62

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 188.41  E-value: 3.45e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573    5 LTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTG 84
Cdd:TIGR00581   1 LTHIDEQGAARMVDISAKAETVREAVASGFVRMKPETVAMISEGRVPKGDVLATARVAGIMAAKRTGDLIPLCHPLPLSK 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489770573   85 VDIHFHNNgQDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKS 152
Cdd:TIGR00581  81 VEVELTVR-EDRVEITATVRTTGRTGVEMEALTAVSVAALTVYDMCKAVDKDMVIGPVRLLEKSGGKS 147
 
Name Accession Description Interval E-value
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
3-158 4.53e-89

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 256.66  E-value: 4.53e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   3 DKLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPL 82
Cdd:PRK09364   2 SQLTHINEQGRAKMVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLML 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489770573  83 TGVDIHFHNNGQ-DTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGHFIFD 158
Cdd:PRK09364  82 TGVDVDFEWDPElPGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKSGDFKRE 158
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
2-153 1.92e-88

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 254.98  E-value: 1.92e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   2 TDKLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIP 81
Cdd:COG0315    1 MSELTHLDEQGRARMVDVSDKAVTARTAVAEGRVRMSPETLALIREGGVKKGDVLAVARIAGIMAAKRTSELIPLCHPLP 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489770573  82 LTGVDIHFH-NNGQDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSG 153
Cdd:COG0315   81 LTGVDVDFElDDDLSGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIEDIRLLEKSGGKSG 153
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
16-150 6.03e-78

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 227.61  E-value: 6.03e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   16 MVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHFH-NNGQ 94
Cdd:pfam01967   1 MVDVSDKPVTLRTAVAEGRIRLSPETLELIREGTVKKGDVLAVARIAGIMAAKKTSDLIPLCHPLPLTGVDVEFElDEEE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489770573   95 DTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGG 150
Cdd:pfam01967  81 DGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGDIRLLEKSGG 136
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
16-154 6.25e-76

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 222.81  E-value: 6.25e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  16 MVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHFHNNGQD 95
Cdd:cd01420    1 MVDVSDKAVTERTAVAEGRVRMSPETLDLITEGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDEET 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  96 -TITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGH 154
Cdd:cd01420   81 sGVRIEATVRTTGRTGVEMEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGKSGD 140
MoaC cd00528
MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, ...
16-150 1.22e-71

MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238293  Cd Length: 136  Bit Score: 211.61  E-value: 1.22e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  16 MVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHF-HNNGQ 94
Cdd:cd00528    1 MVDVSDKAVTERTAVAEGRVRLSPETLDLIREGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFeLDEDT 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489770573  95 DTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGG 150
Cdd:cd00528   81 SGVRIRATVRTTGKTGVEMEALTAVSVAALTIYDMCKAVDKDMVIENIRLLEKSGG 136
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
6-154 1.34e-64

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 199.78  E-value: 1.34e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   6 THFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGV 85
Cdd:PRK03604   1 THLDEEGRVRMVDVSGKPGTLRTARASGIIVTSPETIELLRQGDLPKGDVLTTAKIAGIQAAKRTSELIPLCHPLPLSWV 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489770573  86 DIHFHNNGqDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGH 154
Cdd:PRK03604  81 DVEFEIED-DRIRIEATVKTIGKTGVEMEALTAVSVAALTIYDMLKPVDKALEIGGIRLLEKTGGKSGH 148
PRK14499 PRK14499
cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;
4-162 6.41e-64

cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;


Pssm-ID: 237733 [Multi-domain]  Cd Length: 308  Bit Score: 198.16  E-value: 6.41e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   4 KLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLT 83
Cdd:PRK14499   2 EFTHFNKDGLPQMVDVSSKEPTFRVAVASGRIYVGKEVIEAIEERLLPKGDVFSVAKIAAIMAAKKTSELIPLCHNIFLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  84 GVDIHFH-NNGQDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGHFIFDQQSK 162
Cdd:PRK14499  82 GVDVSYEiNREEGYIEAVSEVKTEAKTGAEMEAITAVSIFLETIYDMCKAVKKDMVITDVRLIEKSGGKSGHYIFERRNK 161
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
5-152 3.45e-62

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 188.41  E-value: 3.45e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573    5 LTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTG 84
Cdd:TIGR00581   1 LTHIDEQGAARMVDISAKAETVREAVASGFVRMKPETVAMISEGRVPKGDVLATARVAGIMAAKRTGDLIPLCHPLPLSK 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489770573   85 VDIHFHNNgQDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKS 152
Cdd:TIGR00581  81 VEVELTVR-EDRVEITATVRTTGRTGVEMEALTAVSVAALTVYDMCKAVDKDMVIGPVRLLEKSGGKS 147
PRK12343 PRK12343
cyclic pyranopterin monophosphate synthase MoaC;
10-147 2.31e-54

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 237067  Cd Length: 151  Bit Score: 168.55  E-value: 2.31e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  10 DQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHF 89
Cdd:PRK12343   3 DEDGVKMVDVSEKEDVLRIAVAEGFIKLKPETIEAIREGEVEKGNVLATARVAGILAVKKTPELIPMCHPIPITGVDVDF 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489770573  90 hNNGQDTITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDR-------GMVISDVHLVEK 147
Cdd:PRK12343  83 -EVGEDGIEARVTVKTTYKTGVEMEALTGVSVALLTIWDMVKAAEKdedgqypETRIENIRVVEK 146
MoaC_A cd01419
MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) ...
16-147 8.01e-52

MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238707  Cd Length: 141  Bit Score: 161.76  E-value: 8.01e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573  16 MVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLTGVDIHFhNNGQD 95
Cdd:cd01419    1 MVDISSKEDVAREAVASGFIKLKEETIKAIREGKVEKGNVIATARIAGILAVKKTPELIPMCHPIPITGVDVDF-EVEED 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489770573  96 TITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDR-------GMVISDVHLVEK 147
Cdd:cd01419   80 GIEVRCTVKTTYKTGVEMEALTGVSVALLTIWDMVKSAEKdedgqypETRIENVRVVEK 138
PRK14500 PRK14500
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; ...
5-152 1.56e-38

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional


Pssm-ID: 237734 [Multi-domain]  Cd Length: 346  Bit Score: 133.87  E-value: 1.56e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   5 LTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQI--KKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPL 82
Cdd:PRK14500   2 FTHLNENQQPRMVDISQKVVSDRRAVAQAIVQLPPAIKDYVTGQDIflKKGPVIQTAIIAGTMAVKRTADLIPFCHTLPI 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489770573  83 TG----VDIHFHNNGQDtITAEATVKTKHVTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKS 152
Cdd:PRK14500  82 HGckfdINIVYQKRDLE-IFLQCAVKTNYKTGVEMEALCGVAVAALTIYDMCKSISPHIIIKETRLIEKSGGKA 154
PLN02375 PLN02375
molybderin biosynthesis protein CNX3
4-155 7.66e-34

molybderin biosynthesis protein CNX3


Pssm-ID: 178003 [Multi-domain]  Cd Length: 270  Bit Score: 119.87  E-value: 7.66e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489770573   4 KLTHFNDQDRARMVDVTAKKVTFRTATAQGQIHMQATTLQRIEDGQIKKGDVLAVAQVAGIMAAKRTSEMIPMCHLIPLT 83
Cdd:PLN02375 115 KLTHVGIAGEAQMVDVSSKDNSKRTALACCKVILGKRVFDLVLANQMGKGDVLGVAKIAGINGAKQTSSLIPLCHNIALT 194
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489770573  84 GVDIHFHNNGQD---TITAEATVKTKhvTGVEIEALLVVQIALLTIYDMCKAMDRGMVISDVHLVEKDGGKSGHF 155
Cdd:PLN02375 195 HVRVDLRLNPEDfsvDIEGEASCTGK--TGVEMEAMTAVSVAGLTVYDMCKAASKDISITDVRLERKTGGKSGSW 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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