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Conserved domains on  [gi|491103444|ref|WP_004964894|]
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MULTISPECIES: cation:proton antiporter regulatory subunit [Haloarcula]

Protein Classification

cation:proton antiporter regulatory subunit( domain architecture ID 11422976)

cation:proton antiporter regulatory subunit modulates the activity of the cation:proton antiporter, similar to K(+)/H(+) antiporter subunit KhtT and ammonium/H(+) antiporter subunit AmhM

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 25-158 1.72e-24

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 92.29  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491103444  25 LVVVTHNTGTRELYLKESADADSEKLLELSDRMARLVGTI-----LEGAYFQPVESSHVETMLSEGTLLEWYAVEADSPL 99
Cdd:COG0490    2 ALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLelallLLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491103444 100 VGETLAGANVGQRTGVTVVAIQRGDDVIPGPTSTVEIEDGDTVVVIGERDNCESFEKLL 158
Cdd:COG0490   82 VGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
 
Name Accession Description Interval E-value
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 25-158 1.72e-24

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 92.29  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491103444  25 LVVVTHNTGTRELYLKESADADSEKLLELSDRMARLVGTI-----LEGAYFQPVESSHVETMLSEGTLLEWYAVEADSPL 99
Cdd:COG0490    2 ALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLelallLLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491103444 100 VGETLAGANVGQRTGVTVVAIQRGDDVIPGPTSTVEIEDGDTVVVIGERDNCESFEKLL 158
Cdd:COG0490   82 VGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 88-158 3.05e-15

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 66.09  E-value: 3.05e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491103444   88 LEWYAVEADSPLVGETLAGANVGQRTGVTVVAIQRGDDVIPgPTSTVEIEDGDTVVVIGERDNCESFEKLL 158
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII-PSGDTVLEAGDRLLVIGTPDDLAALRELL 70
trkA PRK09496
Trk system potassium transporter TrkA;
93-159 8.02e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 50.51  E-value: 8.02e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491103444  93 VEADSPLVGETLAGANVGQRT-GVTVVAIQRGDDVIPgPTSTVEIEDGDTVVVIGERDNCESFEKLLA 159
Cdd:PRK09496 159 VYEGSPLVGKPLSDLREHFPDiDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREHIRAVMSEFG 225
 
Name Accession Description Interval E-value
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 25-158 1.72e-24

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 92.29  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491103444  25 LVVVTHNTGTRELYLKESADADSEKLLELSDRMARLVGTI-----LEGAYFQPVESSHVETMLSEGTLLEWYAVEADSPL 99
Cdd:COG0490    2 ALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLelallLLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491103444 100 VGETLAGANVGQRTGVTVVAIQRGDDVIPGPTSTVEIEDGDTVVVIGERDNCESFEKLL 158
Cdd:COG0490   82 VGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 88-158 3.05e-15

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 66.09  E-value: 3.05e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491103444   88 LEWYAVEADSPLVGETLAGANVGQRTGVTVVAIQRGDDVIPgPTSTVEIEDGDTVVVIGERDNCESFEKLL 158
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII-PSGDTVLEAGDRLLVIGTPDDLAALRELL 70
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
93-160 1.39e-12

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 64.30  E-value: 1.39e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491103444  93 VEADSPLVGETLAGANVGQRTGVTVVAIQRGDDVIPGPTSTVEIEDGDTVVVIGERDNCESFEKLLAG 160
Cdd:COG3273  320 VPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLERLEELAGG 387
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 59-143 5.54e-09

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 53.53  E-value: 5.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491103444  59 RLVGTILEGAYFQPvESSHVETMLSEGTLLEWYAVEADSPLVGETLAGANVGQRTGVTVVAIQRGDDVIPgPTSTVEIED 138
Cdd:COG0569  214 RLAARRIARLLLRP-GVLDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEA 291


                 ....*
gi 491103444 139 GDTVV 143
Cdd:COG0569  292 GDELI 296
trkA PRK09496
Trk system potassium transporter TrkA;
93-159 8.02e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 50.51  E-value: 8.02e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491103444  93 VEADSPLVGETLAGANVGQRT-GVTVVAIQRGDDVIPgPTSTVEIEDGDTVVVIGERDNCESFEKLLA 159
Cdd:PRK09496 159 VYEGSPLVGKPLSDLREHFPDiDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREHIRAVMSEFG 225
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 99-161 8.05e-06

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 44.73  E-value: 8.05e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491103444  99 LVGETLAGANVGQRTGVTVVAIQRGD-DVIPGPTSTVEIedGDTVVVIGERDNCESFEKLLaGD 161
Cdd:COG2985  298 VAGKTLGELNLRNRFGVVITRVRRGGvELPATPDTVLQL--GDRLTVVGPKEDVERVAKLL-GN 358
trkA PRK09496
Trk system potassium transporter TrkA;
91-159 2.48e-05

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 43.19  E-value: 2.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491103444  91 YAVEADSPLVGETLAgaNVGQRTGVTVVAIQRGDDVIpGPTSTVEIEDGDTVVVIGERDNCES-FEKLLA 159
Cdd:PRK09496 383 AVAHETSKVVGKPLK--DLKLPKGVLIGAIVRGGEVI-IPTGDTVIEPGDHVIVFVLDKKFVPdVEKLFQ 449
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 91-158 3.13e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 39.72  E-value: 3.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491103444  91 YAVEADsPLVGETLAGANVGQRTGVTVVAIQRGDDVIPgPTSTVEIEDGDTVVVIGERDNCESFEKLL 158
Cdd:COG2985  207 YRVTNP-NLVGKTVAELEALLGTRVVISRIRRGGEIIV-PTPDTVLQEGDIVLVVGTREALEAAEALL 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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