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The query sequence WP_005365614.1 may be preliminary or obsolete. For more information, check Entrez.
Conserved domains on  [gi|491507980|ref|WP_005365614.1|]
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autorepressor SdpR family transcription factor

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
6-84 5.92e-47

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


:

Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 144.09  E-value: 5.92e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491507980  6 TMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEALLWIKDL 84
Cdd:NF033789  1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
6-84 5.92e-47

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 144.09  E-value: 5.92e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491507980  6 TMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEALLWIKDL 84
Cdd:NF033789  1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-85 1.02e-29

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 101.12  E-value: 1.02e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491507980  3 LQNTMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEALLWIK 82
Cdd:COG0640  10 LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLL 89

                ...
gi 491507980 83 DLR 85
Cdd:COG0640  90 ELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
3-78 1.22e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 95.22  E-value: 1.22e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491507980  3 LQNTMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEAL 78
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
8-85 3.04e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 3.04e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491507980  8 KALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNAsvLDEALLWIKDLR 85
Cdd:cd00090   2 KALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD--AERLLALLESLL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
18-78 8.92e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.92  E-value: 8.92e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491507980   18 ILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEAL 78
Cdd:smart00418  2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLL 62
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
8-63 1.46e-13

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 59.09  E-value: 1.46e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491507980   8 KALADPTRRTIL-NLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGK 63
Cdd:pfam12840  5 EALADPTRLRILrALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
8-83 1.63e-10

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 52.90  E-value: 1.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491507980   8 KALADPTRRTILNLLKK-GRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELN-------ASVLDEALL 79
Cdd:PRK10141  11 KILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSphipawaAKIIEQAWL 90

                 ....
gi 491507980  80 WIKD 83
Cdd:PRK10141  91 CEQE 94
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
6-84 5.92e-47

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 144.09  E-value: 5.92e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491507980  6 TMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEALLWIKDL 84
Cdd:NF033789  1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-85 1.02e-29

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 101.12  E-value: 1.02e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491507980  3 LQNTMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEALLWIK 82
Cdd:COG0640  10 LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLL 89

                ...
gi 491507980 83 DLR 85
Cdd:COG0640  90 ELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
3-78 1.22e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 95.22  E-value: 1.22e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491507980  3 LQNTMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEAL 78
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
8-85 3.04e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 3.04e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491507980  8 KALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNAsvLDEALLWIKDLR 85
Cdd:cd00090   2 KALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD--AERLLALLESLL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
18-78 8.92e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.92  E-value: 8.92e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491507980   18 ILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVLDEAL 78
Cdd:smart00418  2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLL 62
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-78 1.77e-14

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 62.74  E-value: 1.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491507980   1 MSLQNTMKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREG-----KYIIYELNASVLD 75
Cdd:COG1777    5 EDLDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGredgrARKYYRLSAFRLE 84

                 ...
gi 491507980  76 EAL 78
Cdd:COG1777   85 VTL 87
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-61 2.49e-14

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 62.28  E-value: 2.49e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 491507980  7 MKALADPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDERE 61
Cdd:COG4189  13 LKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
8-63 1.46e-13

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 59.09  E-value: 1.46e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491507980   8 KALADPTRRTIL-NLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGK 63
Cdd:pfam12840  5 EALADPTRLRILrALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
4-74 2.34e-13

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 61.05  E-value: 2.34e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491507980   4 QNTMKALADPTRRTIL-NLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELNASVL 74
Cdd:COG3398   88 KKILAYLRRETPRRILlYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPER 159
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
12-56 6.62e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 54.37  E-value: 6.62e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 491507980  12 DPTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLI 56
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
1-62 6.15e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 55.70  E-value: 6.15e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491507980   1 MSLQNTMKALADPTRRTILNLLKK-GRLSAGEIAENFDMSLPAVSKHLAILKDADLI--RDEREG 62
Cdd:COG2345    1 MTDTPALAALADPTRRRILELLKRaGPVTAAELAEALGLTPNAVRRHLDALEEEGLVerETERRG 65
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
8-83 1.63e-10

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 52.90  E-value: 1.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491507980   8 KALADPTRRTILNLLKK-GRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYELN-------ASVLDEALL 79
Cdd:PRK10141  11 KILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSphipawaAKIIEQAWL 90

                 ....
gi 491507980  80 WIKD 83
Cdd:PRK10141  91 CEQE 94
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
13-69 7.23e-06

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 41.80  E-value: 7.23e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491507980  13 PTRRTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIrdEREGKyiIYEL 69
Cdd:COG4742   16 EKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLI--ERDDG--EYEL 68
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
14-56 8.49e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 36.26  E-value: 8.49e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 491507980  14 TRRTILNLL-KKGRLSAGEIAENFDMSLPAVSKHLAILKDADLI 56
Cdd:pfam13412  2 TDRKILNLLqENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
16-69 8.88e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.20  E-value: 8.88e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 491507980 16 RTILNLLKK--GRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDEREGKYIIYEL 69
Cdd:COG2512  18 RRVLELLREngGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVEL 73
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
12-57 4.31e-04

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 36.29  E-value: 4.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 491507980  12 DPTRRTILNLLKK-GRLSAGEIAENFDMSLPAVSKHLAILKDADLIR 57
Cdd:COG1522    4 DEIDRRILRLLQEdGRLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
26-66 3.67e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 32.41  E-value: 3.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 491507980   26 RLSAGEIAENFDMSLPAVSKHLAILKDADLIrdEREGKYII 66
Cdd:smart00419  8 PLTRQEIAELLGLTRETVSRTLKRLEKEGLI--SREGGRIV 46
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
16-60 6.89e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 31.79  E-value: 6.89e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 491507980  16 RTILNLLKKGRLSAGEIAENFDMSLPAVSKHLAILKDADLIRDER 60
Cdd:pfam12802  9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
 
Blast search parameters
Data Source: Live blast search RID = KVTH6R8J013
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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