dTDP-4-dehydrorhamnose 3,5-epimerase family protein such as dTDP-4-keto-6-deoxy-D-glucose epimerase that converts dTDP-4-dehydro-6-deoxy-alpha-D-glucose into dTDP-4-dehydro-beta-L-rhamnose or dTDP-4-dehydro-6-deoxy-alpha-D-allose
dTDP-4-dehydrorhamnose 3,5-epimerase; This family catalyze the isomerization of ...
12-174
3.13e-108
dTDP-4-dehydrorhamnose 3,5-epimerase; This family catalyze the isomerization of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.
Pssm-ID: 459991 Cd Length: 164 Bit Score: 305.84 E-value: 3.13e-108
dTDP-4-dehydrorhamnose 3,5-epimerase; This enzyme participates in the biosynthesis of ...
2-176
3.36e-104
dTDP-4-dehydrorhamnose 3,5-epimerase; This enzyme participates in the biosynthesis of dTDP-L-rhamnose, often as a precursor to LPS O-antigen [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 273510 Cd Length: 176 Bit Score: 296.23 E-value: 3.36e-104
RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production; RmlC (deoxythymidine ...
3-169
8.48e-104
RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production; RmlC (deoxythymidine diphosphate (dTDP)-4-keto-6-deoxy-D-hexulose 3, 5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; also known as RfbC) is a carbohydrate epimerase involved in the production of dTDP-L-rhamnose, a precursor of the bacterial cell wall constituent, L-rhamnose. L-Rhamnose (6-deoxy-l-mannose) plays an important role in the cell-wall structure of many bacterial species. It has been found to contribute to the virulence of several species, including the Gram-negative Salmonella enterica and Vibrio cholerae, where it is present as a part of the O-antigen, and is essential for the growth of Gram-positive bacteria such as Streptococcus pyogenes. RmlC converts dTDP-6-deoxy-D-xylo-4-hexulose to dTDP-6-deoxy-L-xylo-hexulose by catalyzing the epimerization of the 5-methyl and 3-hydroxyl groups of hexulose, the third of four steps in the dTDP-L-rhamnose biosynthetic pathway. RmlC belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.
Pssm-ID: 380337 Cd Length: 168 Bit Score: 295.10 E-value: 8.48e-104
dTDP-4-dehydrorhamnose 3,5-epimerase; This family catalyze the isomerization of ...
12-174
3.13e-108
dTDP-4-dehydrorhamnose 3,5-epimerase; This family catalyze the isomerization of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.
Pssm-ID: 459991 Cd Length: 164 Bit Score: 305.84 E-value: 3.13e-108
dTDP-4-dehydrorhamnose 3,5-epimerase; This enzyme participates in the biosynthesis of ...
2-176
3.36e-104
dTDP-4-dehydrorhamnose 3,5-epimerase; This enzyme participates in the biosynthesis of dTDP-L-rhamnose, often as a precursor to LPS O-antigen [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 273510 Cd Length: 176 Bit Score: 296.23 E-value: 3.36e-104
RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production; RmlC (deoxythymidine ...
3-169
8.48e-104
RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production; RmlC (deoxythymidine diphosphate (dTDP)-4-keto-6-deoxy-D-hexulose 3, 5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; also known as RfbC) is a carbohydrate epimerase involved in the production of dTDP-L-rhamnose, a precursor of the bacterial cell wall constituent, L-rhamnose. L-Rhamnose (6-deoxy-l-mannose) plays an important role in the cell-wall structure of many bacterial species. It has been found to contribute to the virulence of several species, including the Gram-negative Salmonella enterica and Vibrio cholerae, where it is present as a part of the O-antigen, and is essential for the growth of Gram-positive bacteria such as Streptococcus pyogenes. RmlC converts dTDP-6-deoxy-D-xylo-4-hexulose to dTDP-6-deoxy-L-xylo-hexulose by catalyzing the epimerization of the 5-methyl and 3-hydroxyl groups of hexulose, the third of four steps in the dTDP-L-rhamnose biosynthetic pathway. RmlC belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.
Pssm-ID: 380337 Cd Length: 168 Bit Score: 295.10 E-value: 8.48e-104
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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