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Conserved domains on  [gi|493312210|ref|WP_006269676|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacteria]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2865 COG2865
Predicted transcriptional regulator, contains HTH domain [Transcription];
4-126 6.12e-27

Predicted transcriptional regulator, contains HTH domain [Transcription];


:

Pssm-ID: 442112  Cd Length: 123  Bit Score: 104.97  E-value: 6.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493312210   4 DEIKKLIQNGEKIDVEFKESRNaLTKDVFDTVCSFNNRNGGHILLGVNDKRDIVGVseDKVDKIIKEFTTSINNsqKMYP 83
Cdd:COG2865    1 EELKELLAGGESETLEFKESLN-EPDEILKTVCAFANTEGGTLLIGVDDDGEIVGL--DDPDKLLERLENLIAD--NISP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 493312210  84 PLYLLPEVFELDSKKVIYIRVPEGYQ---VCRHNGRIWDRSYEGDI 126
Cdd:COG2865   76 PIRPDVEEVEIDGKRVLVIEVPPGPSkpyYLKGKGGAYIRVGSSSR 121
HATPase_c_4 super family cl38435
Putative ATP-dependent DNA helicase recG C-terminal; This domain may well interact selectively ...
 335-386 1.43e-04

Putative ATP-dependent DNA helicase recG C-terminal; This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


The actual alignment was detected with superfamily member pfam13749:

Pssm-ID: 463975  Cd Length: 88  Bit Score: 40.59  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 493312210  335 PFPKNPAISKVFREIGLADELGSGMRNTYKYTRLYSGVDPLF-EEGDIFRTII 386
Cdd:pfam13749  36 SKSRNPLLASLFRRLGLIEERGSGIRRILEAMEEAGLPEPEFiEDGDSFRVTL 88
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 420-474 2.06e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member cd00092:

Pssm-ID: 481199 [Multi-domain]  Cd Length: 67  Bit Score: 36.49  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493312210 420 LAEFIKEKIRGNNKITRKAIADEAGVSVKTIERTIKEMDNLQYVGSGSNGHWELN 474
Cdd:cd00092   12 LSLRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVN 66
 
Name Accession Description Interval E-value
COG2865 COG2865
Predicted transcriptional regulator, contains HTH domain [Transcription];
4-126 6.12e-27

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 442112  Cd Length: 123  Bit Score: 104.97  E-value: 6.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493312210   4 DEIKKLIQNGEKIDVEFKESRNaLTKDVFDTVCSFNNRNGGHILLGVNDKRDIVGVseDKVDKIIKEFTTSINNsqKMYP 83
Cdd:COG2865    1 EELKELLAGGESETLEFKESLN-EPDEILKTVCAFANTEGGTLLIGVDDDGEIVGL--DDPDKLLERLENLIAD--NISP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 493312210  84 PLYLLPEVFELDSKKVIYIRVPEGYQ---VCRHNGRIWDRSYEGDI 126
Cdd:COG2865   76 PIRPDVEEVEIDGKRVLVIEVPPGPSkpyYLKGKGGAYIRVGSSSR 121
AlbA_2 pfam04326
Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.
 14-107 9.48e-15

Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.


Pssm-ID: 461263  Cd Length: 116  Bit Score: 70.41  E-value: 9.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493312210   14 EKIDVEFKESRNALTKDVF-DTVCSFNNRNGGHILLGVNDKRDIVGVSEDKVDkiiKEFTTSINNSQKMYPPLYLLPEVF 92
Cdd:pfam04326   1 ESETLEFKESLGKSSKKKIaKTISAFANTEGGTIVIGVDDTGKIVGVSDDEKD---TEDLLKNQILDLIKPPIEVDIEEI 77

                          90
                  ....*....|....*
gi 493312210   93 ELDSKKVIYIRVPEG 107
Cdd:pfam04326  78 EIDGKYVLVVEIPEG 92
HATPase_c_4 pfam13749
Putative ATP-dependent DNA helicase recG C-terminal; This domain may well interact selectively ...
 335-386 1.43e-04

Putative ATP-dependent DNA helicase recG C-terminal; This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


Pssm-ID: 463975  Cd Length: 88  Bit Score: 40.59  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 493312210  335 PFPKNPAISKVFREIGLADELGSGMRNTYKYTRLYSGVDPLF-EEGDIFRTII 386
Cdd:pfam13749  36 SKSRNPLLASLFRRLGLIEERGSGIRRILEAMEEAGLPEPEFiEDGDSFRVTL 88
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 420-474 2.06e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 36.49  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493312210 420 LAEFIKEKIRGNNKITRKAIADEAGVSVKTIERTIKEMDNLQYVGSGSNGHWELN 474
Cdd:cd00092   12 LSLRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVN 66
 
Name Accession Description Interval E-value
COG2865 COG2865
Predicted transcriptional regulator, contains HTH domain [Transcription];
4-126 6.12e-27

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 442112  Cd Length: 123  Bit Score: 104.97  E-value: 6.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493312210   4 DEIKKLIQNGEKIDVEFKESRNaLTKDVFDTVCSFNNRNGGHILLGVNDKRDIVGVseDKVDKIIKEFTTSINNsqKMYP 83
Cdd:COG2865    1 EELKELLAGGESETLEFKESLN-EPDEILKTVCAFANTEGGTLLIGVDDDGEIVGL--DDPDKLLERLENLIAD--NISP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 493312210  84 PLYLLPEVFELDSKKVIYIRVPEGYQ---VCRHNGRIWDRSYEGDI 126
Cdd:COG2865   76 PIRPDVEEVEIDGKRVLVIEVPPGPSkpyYLKGKGGAYIRVGSSSR 121
AlbA_2 pfam04326
Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.
 14-107 9.48e-15

Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.


Pssm-ID: 461263  Cd Length: 116  Bit Score: 70.41  E-value: 9.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493312210   14 EKIDVEFKESRNALTKDVF-DTVCSFNNRNGGHILLGVNDKRDIVGVSEDKVDkiiKEFTTSINNSQKMYPPLYLLPEVF 92
Cdd:pfam04326   1 ESETLEFKESLGKSSKKKIaKTISAFANTEGGTIVIGVDDTGKIVGVSDDEKD---TEDLLKNQILDLIKPPIEVDIEEI 77

                          90
                  ....*....|....*
gi 493312210   93 ELDSKKVIYIRVPEG 107
Cdd:pfam04326  78 EIDGKYVLVVEIPEG 92
HATPase_c_4 pfam13749
Putative ATP-dependent DNA helicase recG C-terminal; This domain may well interact selectively ...
 335-386 1.43e-04

Putative ATP-dependent DNA helicase recG C-terminal; This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


Pssm-ID: 463975  Cd Length: 88  Bit Score: 40.59  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 493312210  335 PFPKNPAISKVFREIGLADELGSGMRNTYKYTRLYSGVDPLF-EEGDIFRTII 386
Cdd:pfam13749  36 SKSRNPLLASLFRRLGLIEERGSGIRRILEAMEEAGLPEPEFiEDGDSFRVTL 88
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 420-474 2.06e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 36.49  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493312210 420 LAEFIKEKIRGNNKITRKAIADEAGVSVKTIERTIKEMDNLQYVGSGSNGHWELN 474
Cdd:cd00092   12 LSLRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVN 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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