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Conserved domains on  [gi|493822178|ref|WP_006769679|]
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efflux RND transporter permease subunit [Corynebacterium efficiens]

Protein Classification

MMPL family transporter( domain architecture ID 11457272)

MMPL family transporter similar to mycobacterial membrane protein large (MMPL) transporters, which function in the export of lipid components across the cell envelope; belongs to a subfamily of the resistance-nodulation-cell division (RND) permeases

Gene Ontology:  GO:0016020|GO:0005215
PubMed:  10941792|28340510
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 30-727 4.20e-165

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


:

Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 492.74  E-value: 4.20e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  30 LPAVLILVWLAAAGVGGPYFGKVGE-VSSNDQTayLPeSSDATQVQQQLGE-FSDSDSIPAVVVMVGDE-PLTEQEI-GE 105
Cdd:COG2409    4 HRWLVLLAWLVLLVALGVLAPQLGGsLSSNGFF--LP-GSESQRAADLLAEaFPESDGASAVVVVEAPDgTLTDPAFrAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 106 LNAVVAGLTELEGVGAEVSP------AIPSEDGLAVQAFVPI--DSGAEVADVVDKLSETLSGQTPDNVTTYVTGPAGFS 177
Cdd:COG2409   81 VAALVARLRADPGVAGVQDPwddpaaGLVSEDGKAALVTVTLdgDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 178 ADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLAKWeiLLLSGQTQGILFILVIGA 257
Cdd:COG2409  161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAF--TDVSSFAPNLLTMLGLGV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 258 ATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTL 337
Cdd:COG2409  239 GIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 338 LPALLFVFGRAAFWPKRPAYEPEVVREEggmpskGIWTKVARLVKNHPRAIWVTTLIVLLAGAAFVPTLKAdGVSQSDLI 417
Cdd:COG2409  319 LPALLALLGRRVFWPRRPRRRRAAAPES------GFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRL-GLPDADSL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 418 LGASEARDGQEALGEHFPGGAGSPAYVLTDETN---------LQQVADVLLSDDSFDGVTVSSTesPAGSAPLTAdgiap 488
Cdd:COG2409  392 PADSPSRQGYDALAEHFPPGSNGPLTVVVESDDdldpadlaaLDALAAALAAVPGVASVQPPTR--PEGTDGDAA----- 464

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 489 mgpgpapaptvvdgqvLIQATLVDAPDSQEAQNSIRDLRATFAD--ENIDALVGGVTATALDTNEASIQDRTLIIPIVLV 566
Cdd:COG2409  465 ----------------RLQVVPDGDPDSPEAIDLVDRLRDAAAPalEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLG 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 567 VILVILMLLLRSIVAPVLLIITTVISFGTAIGVSALLFNTV-----FDFPGADPAVPLYGFVFLVALGIDYNIFLATRVR 641
Cdd:COG2409  529 LIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGwlllgFTPGPLDSFVPLLLFVILFGLGMDYEVFLVSRIR 608

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 642 EETVR-HGTREGILRGLAVTGGVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIDTFLVRAFLVPALFYDIGPKV 720
Cdd:COG2409  609 EEYDRgGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWN 688


                 ....*...
gi 493822178 721 WW-PSKLA 727
Cdd:COG2409  689 WWlPRWLD 696
 
Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 30-727 4.20e-165

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 492.74  E-value: 4.20e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  30 LPAVLILVWLAAAGVGGPYFGKVGE-VSSNDQTayLPeSSDATQVQQQLGE-FSDSDSIPAVVVMVGDE-PLTEQEI-GE 105
Cdd:COG2409    4 HRWLVLLAWLVLLVALGVLAPQLGGsLSSNGFF--LP-GSESQRAADLLAEaFPESDGASAVVVVEAPDgTLTDPAFrAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 106 LNAVVAGLTELEGVGAEVSP------AIPSEDGLAVQAFVPI--DSGAEVADVVDKLSETLSGQTPDNVTTYVTGPAGFS 177
Cdd:COG2409   81 VAALVARLRADPGVAGVQDPwddpaaGLVSEDGKAALVTVTLdgDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 178 ADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLAKWeiLLLSGQTQGILFILVIGA 257
Cdd:COG2409  161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAF--TDVSSFAPNLLTMLGLGV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 258 ATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTL 337
Cdd:COG2409  239 GIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 338 LPALLFVFGRAAFWPKRPAYEPEVVREEggmpskGIWTKVARLVKNHPRAIWVTTLIVLLAGAAFVPTLKAdGVSQSDLI 417
Cdd:COG2409  319 LPALLALLGRRVFWPRRPRRRRAAAPES------GFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRL-GLPDADSL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 418 LGASEARDGQEALGEHFPGGAGSPAYVLTDETN---------LQQVADVLLSDDSFDGVTVSSTesPAGSAPLTAdgiap 488
Cdd:COG2409  392 PADSPSRQGYDALAEHFPPGSNGPLTVVVESDDdldpadlaaLDALAAALAAVPGVASVQPPTR--PEGTDGDAA----- 464

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 489 mgpgpapaptvvdgqvLIQATLVDAPDSQEAQNSIRDLRATFAD--ENIDALVGGVTATALDTNEASIQDRTLIIPIVLV 566
Cdd:COG2409  465 ----------------RLQVVPDGDPDSPEAIDLVDRLRDAAAPalEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLG 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 567 VILVILMLLLRSIVAPVLLIITTVISFGTAIGVSALLFNTV-----FDFPGADPAVPLYGFVFLVALGIDYNIFLATRVR 641
Cdd:COG2409  529 LIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGwlllgFTPGPLDSFVPLLLFVILFGLGMDYEVFLVSRIR 608

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 642 EETVR-HGTREGILRGLAVTGGVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIDTFLVRAFLVPALFYDIGPKV 720
Cdd:COG2409  609 EEYDRgGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWN 688


                 ....*...
gi 493822178 721 WW-PSKLA 727
Cdd:COG2409  689 WWlPRWLD 696
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 29-723 1.06e-70

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 249.12  E-value: 1.06e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178   29 LLPAVLILVWLAAAGVGGPYFGKVGEVSSNDQTAYLPESSDATQVQQQLGE-FSDSDSIPAV-VVMVGDEPLTEQEIGEL 106
Cdd:TIGR00833   1 RSAYGIIGVWIATAISLQLLAPLLEDVSYFRLQAELPGGAASSIAVKEMSAaFQEAIRDPKIiLVLESNERLGDKDYATY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  107 NAVVAGLT-----ELEGVGAEVSPAIP----SEDGLAVQAFVPIDSGA------EVADVVDKLSETLSgqTPDNVTTYVT 171
Cdd:TIGR00833  81 DALIAKLRadimhVISVVDFWGPPEAAeglrSDDGKATIIIVNLAGEKgqkeaqEAINAVRRIVEQTN--APDGLTVHVT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  172 GPAGFSADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLAKWEILLLSGQTQGILF 251
Cdd:TIGR00833 159 GPLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  252 ILVIGAATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAM 331
Cdd:TIGR00833 239 ALVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVAL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  332 LAALTLLPALLFVFGRAAFWPKRpayEPEVVReeggmpskGIWTKVARLVKNHPRAIWVTTLIVLLAGA----------- 400
Cdd:TIGR00833 319 LNAVTLTPALLTLEGREGLMKPG---RKSKIR--------FIWRRLGTAVVRRPWPILVTTLIISGVSLlalplirtgyd 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  401 ----------------------------------------------------------------AFVPTLKADGVSQ--- 413
Cdd:TIGR00833 388 dekmiptdlesvqgyeaadrhfpgnsmdpmvvmiksdhdvrnpalladidrfereikavpginmVQETQRPDGVVIKkty 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  414 -----SDLILGASEARDGQEALGEHFPGGAGSPAYVLTDETNLQQVADVLLSD--------------------------- 461
Cdd:TIGR00833 468 ltfqaGNLGDQLDEFSDQLTSRQAYLLQDAEKIAEAIAGLRLVQAGMRLDGENlgqvslavrlmqqaisklqgsagdvfd 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  462 ----------------------------DSFDGVTVSSTE--SPAGSAPLTADGIAPMGPGPAPAPTVVDGQVLIQAT-- 509
Cdd:TIGR00833 548 ifdplrrfvaaipecranpvcsvareivQAADTVVSSAAKlaDAAGQLARGIADVASALSQVSGLPNALDGIGTQLAQmr 627

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  510 ------------LVD----------------------------------------------------APDSQEAQNSIRD 525
Cdd:TIGR00833 628 esaagvqdllneLSDysmtmgklkgnamgvdfyappriftdpnfkavldyflspdghaarllvygdgSPAGDQGAQEFNA 707

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  526 LRATFAD-------ENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILMLLLRSIVAPVLLIITTVISFGTAIG 598
Cdd:TIGR00833 708 IRTVAEEaiqradlEPAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALG 787

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  599 VSALLFNTVFDfPGADPAVPLYGFVFLVALGIDYNIFLATRVREETvRHGTREGILRGLAVTGGVITSAGLVLASTFAAL 678
Cdd:TIGR00833 788 LSVLAFQHILG-AELHWSVLAGVFVLLVALGVDYNMLLVSRIKEES-PAGNRTGIIRALGSTGGVITAAGLVFAGTMAAL 865

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*
gi 493822178  679 YVIPILFLAQIAFIVAFGVLIDTFLVRAFLVPALFYDIGPKVWWP 723
Cdd:TIGR00833 866 ASAQLTAIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWWP 910
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 64-388 4.25e-33

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 130.49  E-value: 4.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178   64 LPESSDATQVQQQLGEFSDSDSIPAVVVMVGDEPLTEQEIGE-LNAVVAGLTELEGVGAEVSPAI---------PSEDGL 133
Cdd:pfam03176   6 DAPSVRAMDRLGAAFPQADSDPIIVVVLGEGDQALGDAAAEAgYDTLVDALRADTGHVGSVQDFWgdpdtaalfVSPDGK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  134 AVQAFVPIDSGAE-------VADVVDKLSETLsgqTPDNVTTYVTGPAGFSADLGAAFAGIDGLLLAVALAAVLVILVFV 206
Cdd:pfam03176  86 AAYVVVTLEGDPGtteadesVAAVRDAVEQAP---PPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  207 YRSFILPIAVLTTSIFALTAALLVVWWLAKWEILLLSGQTQGILFILVIGAATDYSLLYVARYREELRQYRDKATATLKA 286
Cdd:pfam03176 163 YRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  287 IRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTLLPALLFVFGRAAFWPKRPAYEpevvreeg 366
Cdd:pfam03176 243 VRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPKRDRT-------- 314

                         330       340
                  ....*....|....*....|..
gi 493822178  367 gmpsKGIWTKVARLVKNHPRAI 388
Cdd:pfam03176 315 ----ARWWRRIGRLVVRRPAPV 332
 
Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 30-727 4.20e-165

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 492.74  E-value: 4.20e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  30 LPAVLILVWLAAAGVGGPYFGKVGE-VSSNDQTayLPeSSDATQVQQQLGE-FSDSDSIPAVVVMVGDE-PLTEQEI-GE 105
Cdd:COG2409    4 HRWLVLLAWLVLLVALGVLAPQLGGsLSSNGFF--LP-GSESQRAADLLAEaFPESDGASAVVVVEAPDgTLTDPAFrAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 106 LNAVVAGLTELEGVGAEVSP------AIPSEDGLAVQAFVPI--DSGAEVADVVDKLSETLSGQTPDNVTTYVTGPAGFS 177
Cdd:COG2409   81 VAALVARLRADPGVAGVQDPwddpaaGLVSEDGKAALVTVTLdgDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 178 ADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLAKWeiLLLSGQTQGILFILVIGA 257
Cdd:COG2409  161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAF--TDVSSFAPNLLTMLGLGV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 258 ATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTL 337
Cdd:COG2409  239 GIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 338 LPALLFVFGRAAFWPKRPAYEPEVVREEggmpskGIWTKVARLVKNHPRAIWVTTLIVLLAGAAFVPTLKAdGVSQSDLI 417
Cdd:COG2409  319 LPALLALLGRRVFWPRRPRRRRAAAPES------GFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRL-GLPDADSL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 418 LGASEARDGQEALGEHFPGGAGSPAYVLTDETN---------LQQVADVLLSDDSFDGVTVSSTesPAGSAPLTAdgiap 488
Cdd:COG2409  392 PADSPSRQGYDALAEHFPPGSNGPLTVVVESDDdldpadlaaLDALAAALAAVPGVASVQPPTR--PEGTDGDAA----- 464

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 489 mgpgpapaptvvdgqvLIQATLVDAPDSQEAQNSIRDLRATFAD--ENIDALVGGVTATALDTNEASIQDRTLIIPIVLV 566
Cdd:COG2409  465 ----------------RLQVVPDGDPDSPEAIDLVDRLRDAAAPalEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLG 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 567 VILVILMLLLRSIVAPVLLIITTVISFGTAIGVSALLFNTV-----FDFPGADPAVPLYGFVFLVALGIDYNIFLATRVR 641
Cdd:COG2409  529 LIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGwlllgFTPGPLDSFVPLLLFVILFGLGMDYEVFLVSRIR 608

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 642 EETVR-HGTREGILRGLAVTGGVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIDTFLVRAFLVPALFYDIGPKV 720
Cdd:COG2409  609 EEYDRgGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWN 688


                 ....*...
gi 493822178 721 WW-PSKLA 727
Cdd:COG2409  689 WWlPRWLD 696
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 29-723 1.06e-70

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 249.12  E-value: 1.06e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178   29 LLPAVLILVWLAAAGVGGPYFGKVGEVSSNDQTAYLPESSDATQVQQQLGE-FSDSDSIPAV-VVMVGDEPLTEQEIGEL 106
Cdd:TIGR00833   1 RSAYGIIGVWIATAISLQLLAPLLEDVSYFRLQAELPGGAASSIAVKEMSAaFQEAIRDPKIiLVLESNERLGDKDYATY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  107 NAVVAGLT-----ELEGVGAEVSPAIP----SEDGLAVQAFVPIDSGA------EVADVVDKLSETLSgqTPDNVTTYVT 171
Cdd:TIGR00833  81 DALIAKLRadimhVISVVDFWGPPEAAeglrSDDGKATIIIVNLAGEKgqkeaqEAINAVRRIVEQTN--APDGLTVHVT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  172 GPAGFSADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLAKWEILLLSGQTQGILF 251
Cdd:TIGR00833 159 GPLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  252 ILVIGAATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAM 331
Cdd:TIGR00833 239 ALVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVAL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  332 LAALTLLPALLFVFGRAAFWPKRpayEPEVVReeggmpskGIWTKVARLVKNHPRAIWVTTLIVLLAGA----------- 400
Cdd:TIGR00833 319 LNAVTLTPALLTLEGREGLMKPG---RKSKIR--------FIWRRLGTAVVRRPWPILVTTLIISGVSLlalplirtgyd 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  401 ----------------------------------------------------------------AFVPTLKADGVSQ--- 413
Cdd:TIGR00833 388 dekmiptdlesvqgyeaadrhfpgnsmdpmvvmiksdhdvrnpalladidrfereikavpginmVQETQRPDGVVIKkty 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  414 -----SDLILGASEARDGQEALGEHFPGGAGSPAYVLTDETNLQQVADVLLSD--------------------------- 461
Cdd:TIGR00833 468 ltfqaGNLGDQLDEFSDQLTSRQAYLLQDAEKIAEAIAGLRLVQAGMRLDGENlgqvslavrlmqqaisklqgsagdvfd 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  462 ----------------------------DSFDGVTVSSTE--SPAGSAPLTADGIAPMGPGPAPAPTVVDGQVLIQAT-- 509
Cdd:TIGR00833 548 ifdplrrfvaaipecranpvcsvareivQAADTVVSSAAKlaDAAGQLARGIADVASALSQVSGLPNALDGIGTQLAQmr 627

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  510 ------------LVD----------------------------------------------------APDSQEAQNSIRD 525
Cdd:TIGR00833 628 esaagvqdllneLSDysmtmgklkgnamgvdfyappriftdpnfkavldyflspdghaarllvygdgSPAGDQGAQEFNA 707

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  526 LRATFAD-------ENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILMLLLRSIVAPVLLIITTVISFGTAIG 598
Cdd:TIGR00833 708 IRTVAEEaiqradlEPAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALG 787

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  599 VSALLFNTVFDfPGADPAVPLYGFVFLVALGIDYNIFLATRVREETvRHGTREGILRGLAVTGGVITSAGLVLASTFAAL 678
Cdd:TIGR00833 788 LSVLAFQHILG-AELHWSVLAGVFVLLVALGVDYNMLLVSRIKEES-PAGNRTGIIRALGSTGGVITAAGLVFAGTMAAL 865

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*
gi 493822178  679 YVIPILFLAQIAFIVAFGVLIDTFLVRAFLVPALFYDIGPKVWWP 723
Cdd:TIGR00833 866 ASAQLTAIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWWP 910
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
31-714 1.28e-38

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 153.86  E-value: 1.28e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  31 PAVLILVWLAAAGVGGPYFGKVGevSSNDQTAYLPESSDATQVQQQLGE-FSDSDSIpAVVVMVGDEPLTEQEIGELNAV 109
Cdd:COG1033   15 RKLVLLLFLLLTLLLAYGAPKLE--VDTDFESLLPEDDPSVQAYDEFEEeFGGDDTV-VVAVEGKDDIFTPETLEALREL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 110 VAGLTELEGV-----------------GAEVSPAIP----------------------------SEDGLAVQAFVPID-- 142
Cdd:COG1033   92 TEELEEIPGVdsvtsltnvrategtedGLTVEPLIPdelpaspeelaelrekvlssplyvgrlvSPDGKATLIVVTLDpd 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 143 ---SGAEVADVVDKLSETLSGQTPDNVTTYVTGPAGFSADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTT 219
Cdd:COG1033  172 plsSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLV 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 220 SIFALTAALLVVWWLaKWEILLLSGqtqgILFILVIGAATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGS 299
Cdd:COG1033  252 VLLAVIWTLGLMGLL-GIPLSPLTI----LVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSL 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 300 TVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAAltllpallFVFGRA--AFWPKRPayePEVVREEGGMPSKGIWTKV 377
Cdd:COG1033  327 TTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS--------LTLLPAllSLLPRPK---PKTRRLKKPPELGRLLAKL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 378 ARLVKNHPRAIWVTTLIVLLAGAAFVPTLKADGvSQSDLILGASEARDGQEALGEHFPGG--------AGSPAYVLTDET 449
Cdd:COG1033  396 ARFVLRRPKVILVVALVLAVVSLYGISRLKVEY-DFEDYLPEDSPIRQDLDFIEENFGGSdplevvvdTGEPDGLKDPEV 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 450 --NLQQVADVLLSDDSFDGVT-----------VSSTESPAGSA-PLTADGIAPMGPGPAPAPTVV-------DGQ---VL 505
Cdd:COG1033  475 lkEIDRLQDYLESLPEVGKVLsladlvkelnqALNEGDPKYYAlPESRELLAQLLLLLSSPPGDDlsrfvdeDYSaarVT 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 506 IQATLVDAPDSQEAQNSIRD-LRATFADENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILMLLLRSIVAPVL 584
Cdd:COG1033  555 VRLKDLDSEEIKALVEEVRAfLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLI 634

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 585 LIITTVISFGTAIGVSAlLFNTVFDfpgadpavPLYGFVFLVALGI--DYNIFLATRVREETVRHGT-REGILRGLAVTG 661
Cdd:COG1033  635 SLIPNLLPILLTFGLMG-LLGIPLN--------IATAVVASIALGIgvDYTIHFLSRYREERRKGGDlEEAIRRALRTTG 705

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|...
gi 493822178 662 GVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIdTFLVRAFLVPALFY 714
Cdd:COG1033  706 KAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV-ALLAALLLLPALLL 757
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 64-388 4.25e-33

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 130.49  E-value: 4.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178   64 LPESSDATQVQQQLGEFSDSDSIPAVVVMVGDEPLTEQEIGE-LNAVVAGLTELEGVGAEVSPAI---------PSEDGL 133
Cdd:pfam03176   6 DAPSVRAMDRLGAAFPQADSDPIIVVVLGEGDQALGDAAAEAgYDTLVDALRADTGHVGSVQDFWgdpdtaalfVSPDGK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  134 AVQAFVPIDSGAE-------VADVVDKLSETLsgqTPDNVTTYVTGPAGFSADLGAAFAGIDGLLLAVALAAVLVILVFV 206
Cdd:pfam03176  86 AAYVVVTLEGDPGtteadesVAAVRDAVEQAP---PPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  207 YRSFILPIAVLTTSIFALTAALLVVWWLAKWEILLLSGQTQGILFILVIGAATDYSLLYVARYREELRQYRDKATATLKA 286
Cdd:pfam03176 163 YRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  287 IRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTLLPALLFVFGRAAFWPKRPAYEpevvreeg 366
Cdd:pfam03176 243 VRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPKRDRT-------- 314

                         330       340
                  ....*....|....*....|..
gi 493822178  367 gmpsKGIWTKVARLVKNHPRAI 388
Cdd:pfam03176 315 ----ARWWRRIGRLVVRRPAPV 332
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 428-725 7.76e-33

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 129.72  E-value: 7.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  428 EALGEHFPGGAGSP-AYVLTDETNL-------QQVADVLLSDDSFDGVTVSSTESPAGsAPLTADGiapmgpgpapaPTV 499
Cdd:pfam03176  14 DRLGAAFPQADSDPiIVVVLGEGDQalgdaaaEAGYDTLVDALRADTGHVGSVQDFWG-DPDTAAL-----------FVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  500 VDGQ-VLIQATLVDAPDSQEAQNSIRDLRA----TFADENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILML 574
Cdd:pfam03176  82 PDGKaAYVVVTLEGDPGTTEADESVAAVRDaveqAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  575 LLRSIVAPVLLIITTVISFGTAIGVsALLFNTVFDFPGADPAVPLyGFVFLVALGIDYNIFLATRVREETVRHGTR-EGI 653
Cdd:pfam03176 162 VYRSVVAALLPLLTVGLSLGAAQGL-VAILAHILGIGLSTFALNL-LVVLLIAVGTDYALFLVSRYREELRAGEDReEAV 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493822178  654 LRGLAVTGGVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIDTFLVRAFLvPALFYDIGPKVWWPSK 725
Cdd:pfam03176 240 IRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLL-PALLALLGRWGLWPPK 310
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 205-713 2.12e-19

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 92.98  E-value: 2.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  205 FVYRSFILPIAVLTTSIFALTAALLVVWWLAkweiLLLSGQTQGIlFILVIGAATDYSLLYVARYREELRQYRDKATATL 284
Cdd:TIGR00921 212 LDFKRWWRPLLPLVIILFGVAWVLGIMGWLG----IPLYATTLLA-VPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIV 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  285 KAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTLLPALLFVFgraAFWPKRPAYEPEVVRE 364
Cdd:TIGR00921 287 TAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSI---DIGREKVKKEIIAIGG 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  365 EGGMPSKGIWtKVARLVKNHPRAIWVTTLIVLLAGAAFVPTLKADgVSQSDLI---LGASEARDGQEALgehfPGGAGSP 441
Cdd:TIGR00921 364 KSSEIEEELS-KVLSITVRHPVPALVAALIITGLGLYGAAGIKPE-VNIEKFIpqdLPSLQARKVIESH----MGGSHDF 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  442 AYVLT---DETNLQQVADVL-LSDDS---------FDGVTVSSTESPAGSAPLTADGIAPMGPGPAPAPTVVDGQVLIQA 508
Cdd:TIGR00921 438 ATILVkadDVRDPELVRFMDeLSRDIkatgvaarvFGAPSIIDLVKEVEGLPAPERSALEPIPEDEEGGYISGGQIKVAV 517

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  509 TLVDapDSQEAQNSIRD--LRAT-FAD--ENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILMLLLRSIVAPV 583
Cdd:TIGR00921 518 IQVQ--LKQGEPKVQGRkiLRDVqHEHppPGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAV 595

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  584 LLIIttvisfgtAIGVSALLFNTVFDFPGADPAVPLYGFV-FLVALGIDYNIFLATRVREETVRHGTREGILRGLAVTGG 662
Cdd:TIGR00921 596 FPLI--------AIGSGILWAIGLMGLRGIPSFLAMATTIsIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGP 667

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 493822178  663 VITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIDTFLvrAFLV-PALF 713
Cdd:TIGR00921 668 GILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTA--ALVVfPALL 717
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 24-290 2.00e-17

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 86.74  E-value: 2.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  24 RWVRVLLPAVLILVwLAAAGVGGPYFGkvgevssNDQTAYLPESSDATQVQQQLGE-FSDSDSIPAVVVMVGDEPLTEQE 102
Cdd:COG2409  359 RPVPVLVAAVAVLL-ALALPALGLRLG-------LPDADSLPADSPSRQGYDALAEhFPPGSNGPLTVVVESDDDLDPAD 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 103 IGELNAVVAGLTELEGVgAEVSPAIPSE--DGLAVQAFVPIDSG---AEVADVVDKLSETLSGQTPDnVTTYVTGPAGFS 177
Cdd:COG2409  431 LAALDALAAALAAVPGV-ASVQPPTRPEgtDGDAARLQVVPDGDpdsPEAIDLVDRLRDAAAPALEG-AEVLVGGTTAVN 508

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 178 ADLGAAFAGIDGLLLAVALAAVLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLAKWEILLLSGQTQGI-------L 250
Cdd:COG2409  509 IDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGWLLLGFTPGPLdsfvpllL 588

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 493822178 251 FILVIGAATDYSLLYVARYREELRQYRDKATATLKAIRAT 290
Cdd:COG2409  589 FVILFGLGMDYEVFLVSRIREEYDRGGGTREAVIRGLART 628
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
376-714 2.92e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 82.99  E-value: 2.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 376 KVARLVKNHPRAIWVTTLIVLLAGAAFVPTLKADGvSQSDLILGASEARDGQEALGEHFPGGAG------SPAYVLTDET 449
Cdd:COG1033    6 RLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDT-DFESLLPEDDPSVQAYDEFEEEFGGDDTvvvaveGKDDIFTPET 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 450 --NLQQVADVLLSDDSFDGVT-------VSSTESPAGSAPLTADGIAPMGPGPAPAPTVV-------------DGQV-LI 506
Cdd:COG1033   85 leALRELTEELEEIPGVDSVTsltnvraTEGTEDGLTVEPLIPDELPASPEELAELREKVlssplyvgrlvspDGKAtLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 507 QATLVDAP-----DSQEAQNSIRDLRATFADENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILMLLLRSIVA 581
Cdd:COG1033  165 VVTLDPDPlssdlDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 582 PVLLIITTVISFGTAIGVSALLFNTvFDFPGAdpAVPlygfVFLVALGIDYNIFLATRVREETVRHGT-REGILRGLAVT 660
Cdd:COG1033  245 VLLPLLVVLLAVIWTLGLMGLLGIP-LSPLTI--LVP----PLLLAIGIDYGIHLLNRYREERRKGLDkREALREALRKL 317

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493822178 661 GGVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIdTFLVRAFLVPALFY 714
Cdd:COG1033  318 GPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLL-AFLTSLTLLPALLS 370
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
8-336 5.89e-14

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 75.67  E-value: 5.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178   8 PPDPVQGDKPRKTGPARWVRVL------LPAVLILVWLAAAGVGGPYFGKVgeVSSNDQTAYLPESSDATQVQQQLGE-F 80
Cdd:COG1033  374 RPKPKTRRLKKPPELGRLLAKLarfvlrRPKVILVVALVLAVVSLYGISRL--KVEYDFEDYLPEDSPIRQDLDFIEEnF 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  81 SDSDSIPAVVVMVGDEPLTEQE-IGELNAVVAGLTELEGVGAEVSPA-------------------IPSEDGLAVQA--- 137
Cdd:COG1033  452 GGSDPLEVVVDTGEPDGLKDPEvLKEIDRLQDYLESLPEVGKVLSLAdlvkelnqalnegdpkyyaLPESRELLAQLlll 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 138 ------------------------FVPIDSGAEVADVVDKLSETLSGQTP-DNVTTYVTGPAGFSAD------------L 180
Cdd:COG1033  532 lssppgddlsrfvdedysaarvtvRLKDLDSEEIKALVEEVRAFLAENFPpDGVEVTLTGSAVLFAAinesviesqirsL 611

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 181 GAAFAGIdglllavalaavLVILVFVYRSFILPIAVLTTSIFALTAALLVVWWLakweilllsgqtqGI--------LFI 252
Cdd:COG1033  612 LLALLLI------------FLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLL-------------GIplniatavVAS 666

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 253 LVIGAATDYSLLYVARYREELRQYRDKATATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAML 332
Cdd:COG1033  667 IALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALL 746


                 ....
gi 493822178 333 AALT 336
Cdd:COG1033  747 AALL 750
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 387-725 8.25e-09

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 59.21  E-value: 8.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  387 AIWVTT--LIVLLAGAAFVPTLKADGV--SQSDLILGASEARDGQEaLGEHFPGGAGSPAYVLTDETN------LQQVAD 456
Cdd:TIGR00833   3 AYGIIGvwIATAISLQLLAPLLEDVSYfrLQAELPGGAASSIAVKE-MSAAFQEAIRDPKIILVLESNerlgdkDYATYD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  457 VLLSDDSFDGVTVSSTESPAGSaPLTADGIAPMgpgpapaptvvDGQ-VLIQATLVDAPDSQEAQNSIRDLRA----TFA 531
Cdd:TIGR00833  82 ALIAKLRADIMHVISVVDFWGP-PEAAEGLRSD-----------DGKaTIIIVNLAGEKGQKEAQEAINAVRRiveqTNA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  532 DENIDALVGGVTATALDTNEASIQDRTLIIPIVLVVILVILMLLLRSIVAPVLLIITTVISFGTAIGVSALLFNTvfdfp 611
Cdd:TIGR00833 150 PDGLTVHVTGPLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIP----- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  612 gADPAVPLYGFVFLVAL----GIDYNIFLATRVREETVRHGTREGILR-GLAVTGGVITSAGLVLASTFAALYVIPILFL 686
Cdd:TIGR00833 225 -GLIGVNAQTTVLLTALvigaGTDYAVFLTGRYHEERRKGESLEEAAAeALRGTGKAILGSALTVAVAFLALSLARLPSF 303

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 493822178  687 AQIAFIVAFGVLIdTFLVRAFLVPALFYDIGPKVWWPSK 725
Cdd:TIGR00833 304 KTLGVSCAVGVLV-ALLNAVTLTPALLTLEGREGLMKPG 341
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 161-330 9.62e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 52.53  E-value: 9.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  161 QTPDNVTTYVTGPAGFSADLGAAFAGIDGLLLAVALAAVLVILVFVYRSfilpiavLTTSIFALTAALLVVWWLAKweIL 240
Cdd:TIGR00921 542 HPPPGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRN-------PIKAVFPLIAIGSGILWAIG--LM 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  241 LLSG----QTQGILFILVIGAATDYSLLYVARYREELRQYRDKaTATLKAIRATIEPVLVSGSTVIAGLLCLLFSDLKSN 316
Cdd:TIGR00921 613 GLRGipsfLAMATTISIILGLGMDYSIHLAERYFEERKEHGPK-EAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIM 691

                         170
                  ....*....|....
gi 493822178  317 STLGPVASIGIIFA 330
Cdd:TIGR00921 692 RNFGLVQGIGVLSS 705
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 137-409 3.86e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 50.38  E-value: 3.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  137 AFVPidsGAEVADVVDKLSETLSGQTPDNVTTYVTGPAGFSAD------LGAAFAGIdglllaVALAAVLVILVFVYRSF 210
Cdd:TIGR03480 223 SLEP---AEKAINAIRAAAKDLRLDEDHGVTVRLTGEVALSDEelatvsEGATVAGL------LSFVLVLVLLWLALRSP 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  211 ILPIAVLTTSIFAL--TAALLVvwwLAKWEILLLSgqtqgILF-ILVIGAATDYSLLYVARYREELRQYRDKATATLKAI 287
Cdd:TIGR03480 294 RLVFAVLVTLIVGLilTAAFAT---LAVGHLNLIS-----VAFaVLFIGLGVDFAIQFSLRYREERFRGGNHREALSVAA 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  288 RATIEPVLVSGSTVIAGLLCLLFSDLKSNSTLGPVASIGIIFAMLAALTLLPALLFVFGraafwPKRPAYEPevvreegG 367
Cdd:TIGR03480 366 RRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRLLR-----PPRRRKPP-------G 433

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 493822178  368 MPSKGiwtKVARLVKNHPRAIWVTTLIVLLAGAAFVPTLKAD 409
Cdd:TIGR03480 434 YATLA---PLDAFLRRHRRPVLGVTLILGIAALALLPQLRFD 472
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
207-311 2.75e-05

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 47.79  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  207 YRSFILPIAVLTTSIFALTAALLVVWwlakweillLSGQTQGILF----ILVIGAATDYSLLYVARYREELRQYRDKATA 282
Cdd:COG0841   872 FESFIQPLIILLTVPLALIGALLGLL---------LTGTPLNIYSqiglIMLIGIVVKNAILLVDFANQLREEGMSLREA 942

                          90       100
                  ....*....|....*....|....*....
gi 493822178  283 TLKAIRATIEPVLVSGSTVIAGLLCLLFS 311
Cdd:COG0841   943 ILEAARLRLRPILMTSLATILGLLPLALG 971
COG4258 COG4258
Predicted exporter [General function prediction only];
205-313 2.50e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 41.38  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178 205 FVYRSFILPIAVLTTSIFALTAALLVVWWLAKWeillLSGQTQGILFILvIGAATDYSLLYVARYReelRQYRDKATATL 284
Cdd:COG4258  268 LVFRSLRPLLLGLLPVAVGALAGLAAVSLVFGS----VHGITLGFGSSL-IGVAVDYSLHYLTHRR---AAGEWDPRAAL 339

                         90       100
                 ....*....|....*....|....*....
gi 493822178 285 KAIRATIepvLVSGSTVIAGLLCLLFSDL 313
Cdd:COG4258  340 RRIWPTL---LLGLLTTVLGYLALLFSPF 365
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 205-311 3.25e-03

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 41.13  E-value: 3.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178   205 FVYRSFILPIAVLTTSIFALTAALLVVWwlakweillLSGQTQGIL----FILVIGAATDYSLLYVARYREELRQY-RDK 279
Cdd:pfam00873  881 ALYESWSDPLSIMLTVPLALVGALLALW---------LRGLPNSVYaqvgLILLIGLAVKNAILMVEFANELREQEgKSL 951

                           90       100       110
                   ....*....|....*....|....*....|..
gi 493822178   280 ATATLKAIRATIEPVLVSGSTVIAGLLCLLFS 311
Cdd:pfam00873  952 EEAILEACRLRLRPILMTALAAILGVLPLALS 983
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 623-712 3.83e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 40.75  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493822178  623 VFLVALGIDYNIFLATRVREETVR-HGTREGILRGLAVTGGVITSAGLVLASTFAALYVIPILFLAQIAFIVAFGVLIDT 701
Cdd:TIGR03480 330 VLFIGLGVDFAIQFSLRYREERFRgGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL 409

                          90
                  ....*....|.
gi 493822178  702 FLVRAFLvPAL 712
Cdd:TIGR03480 410 FVTLTVL-PAL 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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