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Conserved domains on  [gi|494409806|ref|WP_007215737|]
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uracil-DNA glycosylase family protein [Bacteroides cellulosilyticus]

Protein Classification

uracil-DNA glycosylase family protein( domain architecture ID 10178247)

uracil-DNA glycosylase family protein; uracil-DNA glycosylase is a DNA repair enzyme that catalyzes the removal of mismatched uracil from DNA to initiate DNA base excision repair pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UDG-F6_HDG cd10032
Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; ...
 6-171 2.10e-45

Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


:

Pssm-ID: 381682  Cd Length: 141  Bit Score: 146.57  E-value: 2.10e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806   6 HPLEPFLPANARLLMLGSFPPQKKRWSMeFYYPNWNNDMWRIVGLLFFNDknhflneaAKAFDKDRIIPFLQKKGIALFD 85
Cdd:cd10032    1 HGFPPVVDENSRVLILGSFPSVKSLEAQ-FYYGHPRNRFWRILGALFGED--------LKALDYEERKAFLLEHGIALWD 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806  86 TATAIRRlqDNASDKFLEVVEPTDIEGMLRRLPECKTIVTTGEKATETlceqfslekpkvgdFTEFVFDGRPMRLYRMPS 165
Cdd:cd10032   72 VLASCRR--KGSLDSAIRNVEPNDIAGLLAKAPNIKAIIFNGKKAARL--------------FKKYVAPLRGIETLRLPS 135


                 ....*.
gi 494409806 166 SSRAYP 171
Cdd:cd10032  136 TSPANA 141
 
Name Accession Description Interval E-value
UDG-F6_HDG cd10032
Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; ...
 6-171 2.10e-45

Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381682  Cd Length: 141  Bit Score: 146.57  E-value: 2.10e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806   6 HPLEPFLPANARLLMLGSFPPQKKRWSMeFYYPNWNNDMWRIVGLLFFNDknhflneaAKAFDKDRIIPFLQKKGIALFD 85
Cdd:cd10032    1 HGFPPVVDENSRVLILGSFPSVKSLEAQ-FYYGHPRNRFWRILGALFGED--------LKALDYEERKAFLLEHGIALWD 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806  86 TATAIRRlqDNASDKFLEVVEPTDIEGMLRRLPECKTIVTTGEKATETlceqfslekpkvgdFTEFVFDGRPMRLYRMPS 165
Cdd:cd10032   72 VLASCRR--KGSLDSAIRNVEPNDIAGLLAKAPNIKAIIFNGKKAARL--------------FKKYVAPLRGIETLRLPS 135


                 ....*.
gi 494409806 166 SSRAYP 171
Cdd:cd10032  136 TSPANA 141
Mug COG3663
G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];
8-182 3.65e-43

G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 442880  Cd Length: 157  Bit Score: 141.46  E-value: 3.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806   8 LEPFLPANARLLMLGSFPPqKKRWSMEFYYPNWNNDMWRIVGLLFFNDknhflneaaKAFDKDRIIPFLQKKGIALFDTA 87
Cdd:COG3663    1 LPPVLAPGLRVLILGSNPG-LASLAAGFYYAHPRNRFWPILGAAGGTD---------PRLDYPERKAFLLEHGIGLWDVV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806  88 TAIRRlQDNASDKFLEVVEPTDIEGMLRRLPECKTIVTTGEKATETLCEQFSLEKPKVGDftefvfdgrpMRLYRMPSSS 167
Cdd:COG3663   71 ARCTR-RAGSLDSAIRNAGPNDLAALLRYRPRIKTVAFNGKTAYRLFFKLVAPQPETIGG----------IELWVLPSPS 139

                        170
                 ....*....|....*.
gi 494409806 168 RAYP-LALEKKAATYR 182
Cdd:COG3663  140 PANArFSLEEKLAAWR 155
 
Name Accession Description Interval E-value
UDG-F6_HDG cd10032
Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; ...
 6-171 2.10e-45

Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381682  Cd Length: 141  Bit Score: 146.57  E-value: 2.10e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806   6 HPLEPFLPANARLLMLGSFPPQKKRWSMeFYYPNWNNDMWRIVGLLFFNDknhflneaAKAFDKDRIIPFLQKKGIALFD 85
Cdd:cd10032    1 HGFPPVVDENSRVLILGSFPSVKSLEAQ-FYYGHPRNRFWRILGALFGED--------LKALDYEERKAFLLEHGIALWD 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806  86 TATAIRRlqDNASDKFLEVVEPTDIEGMLRRLPECKTIVTTGEKATETlceqfslekpkvgdFTEFVFDGRPMRLYRMPS 165
Cdd:cd10032   72 VLASCRR--KGSLDSAIRNVEPNDIAGLLAKAPNIKAIIFNGKKAARL--------------FKKYVAPLRGIETLRLPS 135


                 ....*.
gi 494409806 166 SSRAYP 171
Cdd:cd10032  136 TSPANA 141
Mug COG3663
G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];
8-182 3.65e-43

G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 442880  Cd Length: 157  Bit Score: 141.46  E-value: 3.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806   8 LEPFLPANARLLMLGSFPPqKKRWSMEFYYPNWNNDMWRIVGLLFFNDknhflneaaKAFDKDRIIPFLQKKGIALFDTA 87
Cdd:COG3663    1 LPPVLAPGLRVLILGSNPG-LASLAAGFYYAHPRNRFWPILGAAGGTD---------PRLDYPERKAFLLEHGIGLWDVV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494409806  88 TAIRRlQDNASDKFLEVVEPTDIEGMLRRLPECKTIVTTGEKATETLCEQFSLEKPKVGDftefvfdgrpMRLYRMPSSS 167
Cdd:COG3663   71 ARCTR-RAGSLDSAIRNAGPNDLAALLRYRPRIKTVAFNGKTAYRLFFKLVAPQPETIGG----------IELWVLPSPS 139

                        170
                 ....*....|....*.
gi 494409806 168 RAYP-LALEKKAATYR 182
Cdd:COG3663  140 PANArFSLEEKLAAWR 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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