|
Name |
Accession |
Description |
Interval |
E-value |
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
15-671 |
8.50e-176 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 522.94 E-value: 8.50e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 15 KKKKATVRNVVnGIIIVFLCCVLLGGVTGFFLLSqiigKVSEDERKLEEKIINVEPSTLYSADGKVIYELGAESREIVEY 94
Cdd:COG0744 5 RRGKRLLRRLL-GLLLLLLAVLVLAALAGLVALY----VADLPDPEELEDLALPQTSTIYDRDGTLIATLGDENREWVPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 95 EQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQKDKI 174
Cdd:COG0744 80 DQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARALVANLTAGGVVQGGSTITQQLVKNLF--------------LSNERTL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 175 EMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYqgyds 254
Cdd:COG0744 146 SRKLKEALLALKLERKYSKDEILELYLNTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPY----- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 255 ktkqNYYAYATKRRNETLSLMLSHGYISESEYKLAKATKLAFQlKGESKAKDNPYLAYAQAAITEARELTGEDPATTP-M 333
Cdd:COG0744 221 ----RNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTLV-PPPNGAAAGKYPYFVDYVRRELEELLGEDDLYRGgL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 334 KIYTALDTSTQDRLNDIQEKkviGMPENKY--FQIAASVIDNRKGTIIAIGTGfDDPTSSTYkDRATKEKHQPGSTSKPl 411
Cdd:COG0744 296 KIYTTLDPKLQKAAEKAVKN---VLPEGKPggLQAALVVVDPKTGEVLAMVGG-RDYGKSQF-NRATQAKRQPGSTFKP- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 412 LAYAQAFDQiGWATSRIVEDKPIQIYGDTKS--NYDNKYHGKVSLERALAQSLNIPALEAMQavtnAVGNDYMREYMKKL 489
Cdd:COG0744 370 FVYAAALEQ-GYTPATTVDDEPVTFPGGGWSpkNYDGRYRGPVTLREALANSLNTPAVRLAQ----EVGLDKVVDTARRL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 490 GFDDKVAEkfDLLYAIGGAnfEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENNAKTTQAMSPQAAYMTSDL 569
Cdd:COG0744 445 GITSPLDP--NPSLALGTS--EVSPLEMASAYATFANGGVYVEPHAITKVTDADGKVLYEAKPKCEQVISPEVAYLMTDM 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 570 LNKAI---TGKysgynymsqAFNGAGYPVYGKTGTSDwddyadevggNAHDGWMVNYTSDYTIASWNGFD-----SRVNG 641
Cdd:COG0744 521 LQDVVtsgTGR---------AARLPGRPVAGKTGTTN----------DNRDAWFVGYTPQLVTAVWVGNDdnspmGYVTG 581
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 495963657 642 YT--------YLSEAVQNMNI-----PGKINRYILDSLSSNAT 671
Cdd:COG0744 582 GSlpapiwrdFMEAALEGLPVedfpkPSGVVRIDEPSPTPSGT 624
|
|
| PBP_1a_fam |
TIGR02074 |
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ... |
89-636 |
4.06e-145 |
|
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain] Cd Length: 531 Bit Score: 440.16 E-value: 4.06e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 89 REIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikL 168
Cdd:TIGR02074 2 REYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLY--------------L 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 169 TQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNP 248
Cdd:TIGR02074 68 TNERTITRKIQEALLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 249 YQGYDsktkqnyyaYATKRRNETLSLMLSHGYISESEYKLAKATKLAFQLKgESKAKDNPYLAYAQAAITEARELTGEDP 328
Cdd:TIGR02074 148 FKNPE---------RAKDRRNLVLSNMVENGYITAEEAEEAINEPIQLYLQ-TKKSEQYKAPYFVDYVIQELEEEYGEEL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 329 ATTPMKIYTALDTSTQDRLNDI--QEKKVIGMPENKYFQIAASVIDNRKGTIIAIGTGFDDpTSSTYkDRATKEKHQPGS 406
Cdd:TIGR02074 218 YTGGLKIYTTLDLDAQKAAEKVlnTGLRVAGRRDGDDLQAALVAIDPDTGAVRALVGGRDY-GKSQF-NRATQAKRQPGS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 407 TSKPLLaYAQAFDQiGWATSRIVEDKPIQIYGDTK---SNYDNKYHGKVSLERALAQSLNIPALEAMQavtnAVGNDYMR 483
Cdd:TIGR02074 296 TFKPFV-YAAALEK-GLTPATIVNDEPITYNGNGPwspKNYGGGYRGNVTLRQALAQSRNIPAVRLLQ----EVGLDKVV 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 484 EYMKKLGFDDKvaEKFDLLYAIGGanFEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENNAKTTQAMSPQAA 563
Cdd:TIGR02074 370 ALAKRFGITSP--LDPVLSLALGT--VEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYENKPKTTQVISPATA 445
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495963657 564 YMTSDLLNKAI---TGKYSgynymsqafNGAGYPVYGKTGTSDwddyadevggNAHDGWMVNYTSDYTIASWNGFD 636
Cdd:TIGR02074 446 YIMTDMLKGVVesgTGRSA---------RLPGRPVAGKTGTTQ----------NWRDAWFVGYTPYYVTAVWVGYD 502
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
77-276 |
8.63e-66 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 217.77 E-value: 8.63e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 77 DGKVIYELGAESREIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkp 156
Cdd:pfam00912 1 DGTLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLF--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 157 keekadsegikLTQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFL 236
Cdd:pfam00912 78 -----------LTPERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALL 146
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 495963657 237 AGVVNAPALYNPYqgydsktkqNYYAYATKRRNETLSLML 276
Cdd:pfam00912 147 AGLPQAPSRYNPL---------RNPERAKRRRNLVLDRMV 177
|
|
| mrcA |
PRK11636 |
penicillin-binding protein 1a; Provisional |
25-553 |
5.72e-60 |
|
penicillin-binding protein 1a; Provisional
Pssm-ID: 183248 [Multi-domain] Cd Length: 850 Bit Score: 220.00 E-value: 5.72e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 25 VNGIIIVFLCCVLLGgVTGFFLLSQIIGKVSEDERKLEEKIINVePSTLYSADGKVIYELGAESREIVEYEQIPQVTIDA 104
Cdd:PRK11636 4 VKYLLILAVCCILLG-AGSIYGLYRYIEPQLPDVATLKDVRLQT-PMQVYSADGELIAQYGEKRRIPLTLDQIPPEMVKA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 105 FLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQKDKIEMKIQEIYLS 184
Cdd:PRK11636 82 FIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFF--------------LSPERTLMRKIKEAFLA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 185 LRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYQGYDSktkqnyyayA 264
Cdd:PRK11636 148 IRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAPSTFNPLYSMDR---------A 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 265 TKRRNETLSLMLSHGYISESEYKLAKATKLAFQLKGESKAKDNPYLayAQAAITEARELTGEDPATTPMKIYTALDTSTQ 344
Cdd:PRK11636 219 VARRNVVLSRMLDEGYITQAQYDQARSEPIVANYHAPEIAFSAPYL--SEMVRQEMYNRYGENAYEDGYRVYTTITRKVQ 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 345 -----------------------------------------DRLNDI----------------QEKKVI----------- 356
Cdd:PRK11636 297 qaaqqavrnnvldydmrhgyrgpanvlwkvgesawdnkkitDTLKALptygpllpavvtsanpQEATAMladgssvalpm 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 357 -GMPENKYF---------------------QI------------------AASV-IDNRKGTIIAIGTGFDDPTSSTykD 395
Cdd:PRK11636 377 eGVRWARPYrsdtqqgptprkvtdvvqtgqQIwvrqvddawwlaqvpdvnSALVsINPQNGAVMALVGGFDFNQSKF--N 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 396 RATKEKHQPGSTSKPLLaYAQAFDQiGWATSRIVEDKPIQIYgDTKSNYD-------NKYHGKVSLERALAQSLNIPALE 468
Cdd:PRK11636 455 RATQALRQVGSNIKPFL-YTAAMDK-GLTLASMLNDVPISRW-DAGAGSDwrpknspPQYAGPIRLRQGLGQSKNVVMVR 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 469 AMQavtnAVGNDYMREYMKKLGFDDKVAEKFDLLyAIGGANFeaTPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTY 548
Cdd:PRK11636 532 AMR----AMGVDYAAEYLQRFGFPAQNIVHTESL-ALGSASF--TPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIF 604
|
....*
gi 495963657 549 ENNAK 553
Cdd:PRK11636 605 EAKPK 609
|
|
| FIVAR |
pfam07554 |
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell ... |
712-771 |
3.12e-05 |
|
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as pfam05089 further supports this proposal. It is found in the C-terminal part of Swiss:O82833, which is removed during maturation. Some of the proteins it is found in are involved in methicillin resistance. The name FIVAR derives from Found In Various Architectures.
Pssm-ID: 400096 [Multi-domain] Cd Length: 69 Bit Score: 42.69 E-value: 3.12e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495963657 712 ALKSPISDASKYKQS----DYTPETWAALQEALKQANALLNK---EDVTEDEVNRAKQALENAIRGL 771
Cdd:pfam07554 2 ALKTSINDKNATKTSsnyiNADNDKKAAYNNAITAAKAILNKtnnPNATQEEVNQALTKLNTAINAL 68
|
|
| PqqL |
COG0612 |
Predicted Zn-dependent peptidase, M16 family [General function prediction only]; |
730-835 |
5.71e-04 |
|
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain] Cd Length: 427 Bit Score: 43.37 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 730 PETWAALQEALKQANALLNKEDVTEDEVNRAKQALENA-IRGLKekevavTTTSLTSAIQNAAAYTDTTKYQSAYVQALN 808
Cdd:COG0612 322 PDKLEEALAAILEELERLAKEGVTEEELERAKNQLLGSlALSLE------SNSGLASQLGRYELYGGDLDYLEEYLERIE 395
|
90 100
....*....|....*....|....*..
gi 495963657 809 SrinaanalltssgVTQAEINQAVQDI 835
Cdd:COG0612 396 A-------------VTAEDVQAVARKY 409
|
|
| FIVAR |
pfam07554 |
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell ... |
781-841 |
6.35e-03 |
|
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as pfam05089 further supports this proposal. It is found in the C-terminal part of Swiss:O82833, which is removed during maturation. Some of the proteins it is found in are involved in methicillin resistance. The name FIVAR derives from Found In Various Architectures.
Pssm-ID: 400096 [Multi-domain] Cd Length: 69 Bit Score: 36.14 E-value: 6.35e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495963657 781 TSLTSAIQNAAAYTDTTKYQSAY---VQALNSRINAANALL---TSSGVTQAEINQAVQDIQAAIEA 841
Cdd:pfam07554 1 KALKTSINDKNATKTSSNYINADndkKAAYNNAITAAKAILnktNNPNATQEEVNQALTKLNTAINA 67
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
15-671 |
8.50e-176 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 522.94 E-value: 8.50e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 15 KKKKATVRNVVnGIIIVFLCCVLLGGVTGFFLLSqiigKVSEDERKLEEKIINVEPSTLYSADGKVIYELGAESREIVEY 94
Cdd:COG0744 5 RRGKRLLRRLL-GLLLLLLAVLVLAALAGLVALY----VADLPDPEELEDLALPQTSTIYDRDGTLIATLGDENREWVPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 95 EQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQKDKI 174
Cdd:COG0744 80 DQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARALVANLTAGGVVQGGSTITQQLVKNLF--------------LSNERTL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 175 EMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYqgyds 254
Cdd:COG0744 146 SRKLKEALLALKLERKYSKDEILELYLNTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPY----- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 255 ktkqNYYAYATKRRNETLSLMLSHGYISESEYKLAKATKLAFQlKGESKAKDNPYLAYAQAAITEARELTGEDPATTP-M 333
Cdd:COG0744 221 ----RNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTLV-PPPNGAAAGKYPYFVDYVRRELEELLGEDDLYRGgL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 334 KIYTALDTSTQDRLNDIQEKkviGMPENKY--FQIAASVIDNRKGTIIAIGTGfDDPTSSTYkDRATKEKHQPGSTSKPl 411
Cdd:COG0744 296 KIYTTLDPKLQKAAEKAVKN---VLPEGKPggLQAALVVVDPKTGEVLAMVGG-RDYGKSQF-NRATQAKRQPGSTFKP- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 412 LAYAQAFDQiGWATSRIVEDKPIQIYGDTKS--NYDNKYHGKVSLERALAQSLNIPALEAMQavtnAVGNDYMREYMKKL 489
Cdd:COG0744 370 FVYAAALEQ-GYTPATTVDDEPVTFPGGGWSpkNYDGRYRGPVTLREALANSLNTPAVRLAQ----EVGLDKVVDTARRL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 490 GFDDKVAEkfDLLYAIGGAnfEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENNAKTTQAMSPQAAYMTSDL 569
Cdd:COG0744 445 GITSPLDP--NPSLALGTS--EVSPLEMASAYATFANGGVYVEPHAITKVTDADGKVLYEAKPKCEQVISPEVAYLMTDM 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 570 LNKAI---TGKysgynymsqAFNGAGYPVYGKTGTSDwddyadevggNAHDGWMVNYTSDYTIASWNGFD-----SRVNG 641
Cdd:COG0744 521 LQDVVtsgTGR---------AARLPGRPVAGKTGTTN----------DNRDAWFVGYTPQLVTAVWVGNDdnspmGYVTG 581
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 495963657 642 YT--------YLSEAVQNMNI-----PGKINRYILDSLSSNAT 671
Cdd:COG0744 582 GSlpapiwrdFMEAALEGLPVedfpkPSGVVRIDEPSPTPSGT 624
|
|
| PBP_1a_fam |
TIGR02074 |
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ... |
89-636 |
4.06e-145 |
|
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain] Cd Length: 531 Bit Score: 440.16 E-value: 4.06e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 89 REIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikL 168
Cdd:TIGR02074 2 REYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLY--------------L 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 169 TQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNP 248
Cdd:TIGR02074 68 TNERTITRKIQEALLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 249 YQGYDsktkqnyyaYATKRRNETLSLMLSHGYISESEYKLAKATKLAFQLKgESKAKDNPYLAYAQAAITEARELTGEDP 328
Cdd:TIGR02074 148 FKNPE---------RAKDRRNLVLSNMVENGYITAEEAEEAINEPIQLYLQ-TKKSEQYKAPYFVDYVIQELEEEYGEEL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 329 ATTPMKIYTALDTSTQDRLNDI--QEKKVIGMPENKYFQIAASVIDNRKGTIIAIGTGFDDpTSSTYkDRATKEKHQPGS 406
Cdd:TIGR02074 218 YTGGLKIYTTLDLDAQKAAEKVlnTGLRVAGRRDGDDLQAALVAIDPDTGAVRALVGGRDY-GKSQF-NRATQAKRQPGS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 407 TSKPLLaYAQAFDQiGWATSRIVEDKPIQIYGDTK---SNYDNKYHGKVSLERALAQSLNIPALEAMQavtnAVGNDYMR 483
Cdd:TIGR02074 296 TFKPFV-YAAALEK-GLTPATIVNDEPITYNGNGPwspKNYGGGYRGNVTLRQALAQSRNIPAVRLLQ----EVGLDKVV 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 484 EYMKKLGFDDKvaEKFDLLYAIGGanFEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENNAKTTQAMSPQAA 563
Cdd:TIGR02074 370 ALAKRFGITSP--LDPVLSLALGT--VEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYENKPKTTQVISPATA 445
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495963657 564 YMTSDLLNKAI---TGKYSgynymsqafNGAGYPVYGKTGTSDwddyadevggNAHDGWMVNYTSDYTIASWNGFD 636
Cdd:TIGR02074 446 YIMTDMLKGVVesgTGRSA---------RLPGRPVAGKTGTTQ----------NWRDAWFVGYTPYYVTAVWVGYD 502
|
|
| MrcA |
COG5009 |
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis]; |
28-636 |
5.98e-130 |
|
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain] Cd Length: 785 Bit Score: 409.16 E-value: 5.98e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 28 IIIVFLCCVLLGGVTGFFLLSQIIgkvsedeRKLE--EKIINVEP---STLYSADGKVIYELGAESREIVEYEQIPQVTI 102
Cdd:COG5009 7 LLILLLLLLLLGALAVAGLYLYLS-------PDLPdvETLKDYQPptpSRVYSADGKLIAEFGEERRIPVPIEEIPPLLI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 103 DAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQKDKIEMKIQEIY 182
Cdd:COG5009 80 NAFLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRVQGGSTITQQVAKNFL--------------LSPERTLTRKIKEAI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 183 LSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYqgydsktkqNYYA 262
Cdd:COG5009 146 LALRIEQELSKDEILELYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPI---------RNPE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 263 YATKRRNETLSLMLSHGYISESEYKLAKATKLAFQLKGESKAKDNPYlaYAQAAITEARELTGEDPATTP-MKIYTALDT 341
Cdd:COG5009 217 RALERRNYVLGRMLELGYITQAEYEAAKAEPLTARYHGASAEVDAPY--FAEMVRRELVERYGEDALYTGgLKVYTTLDP 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 342 STQ-----------------------------------DRLNDI--------------QEKKV-IGMPENKYFQIAAS-- 369
Cdd:COG5009 295 RLQeaaekalrdgllaydrrhgyrgpeahldlaeedwdEALAEVpdvgdlrpavvlevDDKSArVGLRDGETGTLPLEgl 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 370 ----------------------------------------------------VIDNRKGTIIAIGTGFDDPTSSTykDRA 397
Cdd:COG5009 375 kwarpyindnrrgpapksasdvlkpgdvirvrpvadggwrlrqipevqgalvALDPHTGAVLALVGGFDFEQSKF--NRA 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 398 TKEKHQPGSTSKPLLaYAQAFDQiGWATSRIVEDKPIQIYGDTK------SNYDNKYHGKVSLERALAQSLNIPALEAMQ 471
Cdd:COG5009 453 TQAKRQPGSSFKPFV-YAAALDN-GYTPATIINDAPIVFDDGGGggvwrpKNYSGKFYGPTTLREALEKSRNLVTVRLLQ 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 472 avtnAVGNDYMREYMKKLGFDDKVAEkfDLLYAIGGAnfEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENN 551
Cdd:COG5009 531 ----DVGIDYVIDYAERFGIYSKLPP--NLSLALGSG--EVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRAD 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 552 AKT---------------------TQAMSPQAAYMTSDLLNKAITgkySGYNYMSQAFngaGYPVYGKTGTSDwddyade 610
Cdd:COG5009 603 PARacedcdaaewdgaeprlpdpaEQVIDPRTAYQMTSMLRGVVQ---RGTGRRARAL---GRDIAGKTGTTN------- 669
|
730 740
....*....|....*....|....*.
gi 495963657 611 vggNAHDGWMVNYTSDYTIASWNGFD 636
Cdd:COG5009 670 ---DSKDAWFVGFTPDLVAGVWVGFD 692
|
|
| PbpC |
COG4953 |
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ... |
15-636 |
6.04e-83 |
|
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain] Cd Length: 773 Bit Score: 283.26 E-value: 6.04e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 15 KKKKATVRNVVNGIIIVFLCCVLLGGVTGFFLLSqiigkvsederkleeKIINVEPSTL-YSADGKVIYELGAES---RE 90
Cdd:COG4953 2 KRARLRRRRLLALLLALLLLALALWALDRLFPLP---------------LLFAVPYSTVvLDRDGTLLRAFLAADgqwRL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 91 IVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIdnfinkpkeekadsegiKLTQ 170
Cdd:COG4953 67 PVPLDEVSPRYLQALLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIVSGGSTLTMQVA-----------------RLLE 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 171 KDK--IEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNP 248
Cdd:COG4953 130 PRPrtLSGKLRQILRALQLERRYSKDEILELYLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQAPSRRRP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 249 YQgydsktkqnYYAYATKRRNETLSLMLSHGYISESEYKLAKATKLAFQLkgeskaKDNPYLA--YAQAAITEARELTge 326
Cdd:COG4953 210 DR---------NPERARAARDRVLARLAEAGVIDAEEAALALLEPVPARR------RPLPQLAphLARRLLRQLPGGT-- 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 327 dpattpmKIYTALDTSTQDRLNDIQEKKVIGMPENKYFQIAASVIDNRKGTIIA-IG-TGFDDPTSSTYKD--RATKekh 402
Cdd:COG4953 273 -------RIRTTLDAGLQRRLERLVRRYVRRLKQNGIHNAAVLVVDNRTGEVLAyVGsADFFDASRQGQVDmvRALR--- 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 403 QPGSTSKPLLaYAQAFDQiGWATSR-IVEDKPIQIYGDTKSNYDNKYHGKVSLERALAQSLNIPALEamqaVTNAVGNDY 481
Cdd:COG4953 343 SPGSTLKPFL-YGLALDQ-GLIHPEtLLADVPTSFGGYRPENFDGTFQGPVSAREALARSLNIPAVR----LLEALGPAR 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 482 MREYMKKLGFD--DKVAEKFDLLYAIGGAnfEATPTQMAAAFATLANGGKYIEPHMITKvvykdgsktyENNAKTTQAMS 559
Cdd:COG4953 417 FYARLRRAGLRllLPPAEHYGLSLILGGA--EVTLEELVGLYAALARGGEARPLRLLAG----------EPASPGRRLLS 484
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495963657 560 PQAAYMTSD-LLNKAITGKYSGYNYMSQAFngagyPVYGKTGTSdwddYadevgGNaHDGWMVNYTSDYTIASWNG-FD 636
Cdd:COG4953 485 PGAAWLVRDiLSDVPRPDGAFGWRALDSPP-----PIAWKTGTS----Y-----GF-RDAWAVGFTGRYTVGVWVGnPD 548
|
|
| PBP_1b |
TIGR02071 |
penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) ... |
47-683 |
9.40e-83 |
|
penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273952 [Multi-domain] Cd Length: 730 Bit Score: 281.61 E-value: 9.40e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 47 LSQIIGKVSEDERKLEEKIInvepSTLYSADGkviyelgaESREIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFIS 126
Cdd:TIGR02071 117 IENLDNNKEFGFFRLDPKLI----AMLYSPNG--------EQRLFVPRDQFPELLVDTLLATEDRDFYEHDGISLYSIGR 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 127 SAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINF 206
Cdd:TIGR02071 185 AVWVNLTAGRTVQGGSTLTQQLVKNLF--------------LSNERSLWRKANEAYMALILDARYSKDRILELYLNEVYL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 207 GASA----RGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYQgydsktkqnYYAYATKRRNETLSLMLSHGYIS 282
Cdd:TIGR02071 251 GQSGddaiHGFPLASQYYFGRPLGELSLDQVALLVGMVKGPSYYNPWR---------NPDRALERRNLVLRLLQEQKIID 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 283 ESEYKLAKATKLAFQLKGESkakDNPYLAYAQAAITEARELTGEDPATTP-MKIYTALDTSTQDRL-NDIQE-----KKV 355
Cdd:TIGR02071 322 DEEYDMLSARPLGVQKKGGI---ISRQPAFLQLVRRELRQKLGDKVKDLSgLRIFTTLDPVSQSAAeQAVQEtipalKKK 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 356 IGMPEnkyFQIAASVIDNRKGTIIAIgTGFDDPTSSTYkDRATKEKHQPGSTSKP---LLAYAQAfDQigWATSRIVEDK 432
Cdd:TIGR02071 399 KKLPD---LEAAMVVTDRFTGEVRAM-VGGSDPQFAGF-NRALQARRQIGSLVKPavyLTALSQP-DK--YRLNTWIEDQ 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 433 PIQIYGD-----TKSNYDNKYHGKVSLERALAQSLNIPALeamqAVTNAVGNDYMREYMKKLGFDDKVAEKFDLLyaIGG 507
Cdd:TIGR02071 471 PLSIKLSngqvwSPQNYDRRYSGTVMLYDALAHSLNIPTV----NLGMKVGLPKVSQTWNKLGINKDEIPPVPSM--LLG 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 508 AnFEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENNAKTTQAMSPQAAYMTSDLLNKAI---TGKYSGYNYM 584
Cdd:TIGR02071 545 A-INLTPYEVAQLYQTIASGGNRAPLSAVRSVLDEDGKVLYQSDPQAEQAVPSQAAYLTLYAMQQVVqrgTARSLGADFP 623
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 585 SqafngagYPVYGKTGTSDwddyadevggNAHDGWMVNYTSDYTIASWNGFDSrvNGYTYLSEAVQNMnipgKINRYILD 664
Cdd:TIGR02071 624 S-------LSLAGKTGTTN----------DNRDSWFAGIDGKEVTIIWLGRDD--NGPTKLTGASGAL----QVYARYLS 680
|
650
....*....|....*....
gi 495963657 665 SLSSNATRIQNPGGISSYG 683
Cdd:TIGR02071 681 YQTPEPLLLVPPEGIDWFG 699
|
|
| PBP_1c |
TIGR02073 |
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ... |
95-634 |
3.39e-66 |
|
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273954 [Multi-domain] Cd Length: 727 Bit Score: 235.78 E-value: 3.39e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 95 EQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFIN-KPKeekadsegiKLTQKdk 173
Cdd:TIGR02073 39 EDISPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLTNGRRVSGGSTLTMQLARLLDPeLSR---------TLTGK-- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 174 iemkIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYQGYD 253
Cdd:TIGR02073 108 ----LRQMWRAIQLEARYSKREILEAYLNLAPYGGNLEGLRAASLIYFGKEPSSLSLAEAALLAALPQAPSARRLDRLPK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 254 SktkqnyyayATKRRNETLSLMLSHGYISESEYKLAKATKLAFQLkgeskaKDNPYLAYAQaaiteARELTGEDPATTPm 333
Cdd:TIGR02073 184 A---------AKAARDRLLDRMVEQGPDDSEQVALAALEPLPALP------EPLPQLAPHF-----ALKLLRARPEIAS- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 334 KIYTALDTSTQDRLNDIQEKKVIGMPENKYFQIAASVIDNRKGTIIA-IGT-GFDDPTSSTYKDrATKEKHQPGSTSKPL 411
Cdd:TIGR02073 243 VIVSTLDADLQRRLEELARRYLSALRPRGISNLAILVVDNRSGAVLAyVGSaDFFDDSNSGQVD-GVRAPRSPGSTLKPF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 412 LaYAQAFDQIGWATSRIVEDKPIQIYGDTKSNYDNKYHGKVSLERALAQSLNIPALEAMQAVTNAVGNDYMREYMKKLGF 491
Cdd:TIGR02073 322 L-YALALDDGLLHPDSLLKDVPLRFGDYAPENFDKTFHGPVPAREALARSLNIPAVRLLERVGPPRFADFLRQAGLNLLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 492 DDkvAEKFDLLYAIGGAnfEATPTQMAAAFATLANGGKYIEPhmitkvvykdgsKTYENNAKTTQA---MSPQAAYMTSD 568
Cdd:TIGR02073 401 PK--SDYYGLSLALGGA--EITLQDLANLYAMLANQGLSGPL------------RFLQTDAKRPERerlLSPGAAWIVLD 464
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 569 LLnkaitgkySGYNYMSQAFNGA----GYPVYGKTGTSdWDdyadevggnAHDGWMVNYTSDYTIASWNG 634
Cdd:TIGR02073 465 IL--------KDRPRPDDTLPLSalptRLPLAWKTGTS-YG---------FRDAWAAGVSGRYTIGVWVG 516
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
77-276 |
8.63e-66 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 217.77 E-value: 8.63e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 77 DGKVIYELGAESREIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkp 156
Cdd:pfam00912 1 DGTLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLF--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 157 keekadsegikLTQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFL 236
Cdd:pfam00912 78 -----------LTPERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALL 146
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 495963657 237 AGVVNAPALYNPYqgydsktkqNYYAYATKRRNETLSLML 276
Cdd:pfam00912 147 AGLPQAPSRYNPL---------RNPERAKRRRNLVLDRMV 177
|
|
| mrcA |
PRK11636 |
penicillin-binding protein 1a; Provisional |
25-553 |
5.72e-60 |
|
penicillin-binding protein 1a; Provisional
Pssm-ID: 183248 [Multi-domain] Cd Length: 850 Bit Score: 220.00 E-value: 5.72e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 25 VNGIIIVFLCCVLLGgVTGFFLLSQIIGKVSEDERKLEEKIINVePSTLYSADGKVIYELGAESREIVEYEQIPQVTIDA 104
Cdd:PRK11636 4 VKYLLILAVCCILLG-AGSIYGLYRYIEPQLPDVATLKDVRLQT-PMQVYSADGELIAQYGEKRRIPLTLDQIPPEMVKA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 105 FLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQKDKIEMKIQEIYLS 184
Cdd:PRK11636 82 FIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFF--------------LSPERTLMRKIKEAFLA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 185 LRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYQGYDSktkqnyyayA 264
Cdd:PRK11636 148 IRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAPSTFNPLYSMDR---------A 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 265 TKRRNETLSLMLSHGYISESEYKLAKATKLAFQLKGESKAKDNPYLayAQAAITEARELTGEDPATTPMKIYTALDTSTQ 344
Cdd:PRK11636 219 VARRNVVLSRMLDEGYITQAQYDQARSEPIVANYHAPEIAFSAPYL--SEMVRQEMYNRYGENAYEDGYRVYTTITRKVQ 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 345 -----------------------------------------DRLNDI----------------QEKKVI----------- 356
Cdd:PRK11636 297 qaaqqavrnnvldydmrhgyrgpanvlwkvgesawdnkkitDTLKALptygpllpavvtsanpQEATAMladgssvalpm 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 357 -GMPENKYF---------------------QI------------------AASV-IDNRKGTIIAIGTGFDDPTSSTykD 395
Cdd:PRK11636 377 eGVRWARPYrsdtqqgptprkvtdvvqtgqQIwvrqvddawwlaqvpdvnSALVsINPQNGAVMALVGGFDFNQSKF--N 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 396 RATKEKHQPGSTSKPLLaYAQAFDQiGWATSRIVEDKPIQIYgDTKSNYD-------NKYHGKVSLERALAQSLNIPALE 468
Cdd:PRK11636 455 RATQALRQVGSNIKPFL-YTAAMDK-GLTLASMLNDVPISRW-DAGAGSDwrpknspPQYAGPIRLRQGLGQSKNVVMVR 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 469 AMQavtnAVGNDYMREYMKKLGFDDKVAEKFDLLyAIGGANFeaTPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTY 548
Cdd:PRK11636 532 AMR----AMGVDYAAEYLQRFGFPAQNIVHTESL-ALGSASF--TPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIF 604
|
....*
gi 495963657 549 ENNAK 553
Cdd:PRK11636 605 EAKPK 609
|
|
| mrcB |
PRK09506 |
bifunctional glycosyl transferase/transpeptidase; Reviewed |
60-683 |
1.00e-53 |
|
bifunctional glycosyl transferase/transpeptidase; Reviewed
Pssm-ID: 236544 [Multi-domain] Cd Length: 830 Bit Score: 201.15 E-value: 1.00e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 60 KLEEKIInvepSTLYSADGkviyelgaESREIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQ 139
Cdd:PRK09506 194 RLDPRLI----TMLQSPNG--------EQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 140 GGSTLTMQTIDNFInkpkeekadsegikLTQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASA----RGIQK 215
Cdd:PRK09506 262 GGSTLTQQLVKNLF--------------LSNERSLWRKANEAYMALIMDARYSKDRILELYLNEVYLGQSGddqiRGFPL 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 216 GAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPYQGYDsktkqnyyaYATKRRNETLSLMLSHGYISESEYKLAKATKLA 295
Cdd:PRK09506 328 ASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPK---------LALERRNLVLRLLQQQQIIDQELYDMLSARPLG 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 296 FQLKGESKAkdnPYLAYAQAAITEARELTGEDPAT-TPMKIYTALDTSTQdrlnDIQEKKVI-GMPENKY------FQIA 367
Cdd:PRK09506 399 VQPKGGVIS---PQPAFMQMVRQELQAKLGDKVKDlSGVKIFTTLDPVSQ----DAAEKAVEeGIPALKKqrklsdLETA 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 368 ASVIDNRKGTIIAIgTGFDDPTSSTYkDRATKEKHQPGSTSKP---LLAYAQAfDQIGWATsrIVEDKPI---QIYGDTK 441
Cdd:PRK09506 472 MVVVDRFSGEVRAM-VGGSEPQFAGY-NRAMQARRSIGSLAKPatyLTALSQP-DKYRLNT--WIADAPIslrQPNGQVW 546
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 442 S--NYDNKYHGKVSLERALAQSLNIPALE-AMqavtnAVGNDYMREYMKKLGFDDKVAEKFD--LLYAIGganfeATPTQ 516
Cdd:PRK09506 547 SpqNDDRRFSGRVMLVDALTRSMNVPTVNlGM-----ALGLPAVTDTWIKLGVPKDQLNPVPamLLGALN-----LTPIE 616
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 517 MAAAFATLANGGKYIEPHMITKVVYKDGSKTYENNAKTTQAMSPQAAYMTSDLL--------NKAITGKYSGYNymsqaf 588
Cdd:PRK09506 617 VAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSFPQAERAVPAQAAYLTLYTMqqvvqrgtGRQLGAKYPNLH------ 690
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 589 ngagypVYGKTGTSDwddyadevggNAHDGWMVNYTSDYTIASWNGFDSrvNGYTYLSEAVQNMNIpgkINRYiLDSLSS 668
Cdd:PRK09506 691 ------LAGKTGTTN----------DLVDSWFAGIDGKEVTITWVGRDN--NQPTKLYGASGAMTI---YQRY-LENQTP 748
|
650
....*....|....*
gi 495963657 669 NATRIQNPGGISSYG 683
Cdd:PRK09506 749 TPLNLTPPEDIVDMG 763
|
|
| PRK14850 |
PRK14850 |
penicillin-binding protein 1b; Provisional |
80-654 |
6.44e-53 |
|
penicillin-binding protein 1b; Provisional
Pssm-ID: 237835 [Multi-domain] Cd Length: 764 Bit Score: 198.15 E-value: 6.44e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 80 VIYELGAESREIVEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkee 159
Cdd:PRK14850 148 MLYSPEGKKRLFIPRNQYPEMLIKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTIQGGSTLTQQLVKNLF------ 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 160 kadsegikLTQKDKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASA----RGIQKGAQYYFGKNVEQLNLSESAF 235
Cdd:PRK14850 222 --------LTNTRSLWRKINEIYMALILDRFYSKDRILELYLNEVYLGQDGneqiRGFPLASIYYFGRPINELNLDQYAL 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 236 LAGVVNAPALYNPYqgydsktkqNYYAYATKRRNETLSLMLSHGYISESEYKLAKATKLAFQLKGESKAKdnpYLAYAQA 315
Cdd:PRK14850 294 LVGMVKGASLYNPW---------TNPNLTLKRRNLVLFLLYKQKVITRKLYKDLCSRPLNVQSKGNIISS---HPAFIQL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 316 AITEARELTGEDPATTP-MKIYTALDTSTQdrlNDIQEKKVIGMPENKY------FQIAASVIDNRKGTIIAIgTGFDDP 388
Cdd:PRK14850 362 VCEEFHKKIHYPFKNFSgTKIFTTLDYISQ---NAAEQAVKIGIPILKRkkrlkdLEVAMVIIDRFSGEVRAL-IGSSKP 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 389 TSSTYkDRATKEKHQPGSTSKPLLaYAQAFDQIG-WATSRIVEDKPIQIYGD-----TKSNYDNKYHGKVSLERALAQSL 462
Cdd:PRK14850 438 EFNGY-NRALKARRSIGSLSKPIT-YLTALSQPEkYHLNTWISDTPISIKLDngqywTPKNNNFSFSGKVMLIDALIHSI 515
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 463 NIPALEamqaVTNAVGNDYMREYMKKLGFDDKVAEKFDLLyAIGGANFeaTPTQMAAAFATLANGGKYIEPHMITKVVYK 542
Cdd:PRK14850 516 NIPTVH----LSINLGLKKLVDSWILLGISSNYITPLPSI-SLGAINL--TPMEVAQVFQIIGSGGYKSSLSSIRSIISD 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 543 DGSKTYENNAKTTQAMSPQAAYMTSDLLNKAITgkySGYNY-MSQAFNgaGYPVYGKTGTSDwddyadevggNAHDGWMV 621
Cdd:PRK14850 589 DNKVLYQNFPQSKHVESSQASYLTLYAMQQVVK---SGTAKsLGTIFK--EFSLAGKTGTTN----------NLVDSWFV 653
|
570 580 590
....*....|....*....|....*....|...
gi 495963657 622 NYTSDYTIASWNGFDSrvNGYTYLSEAVQNMNI 654
Cdd:PRK14850 654 GIDGKQVVITWIGRDN--NHTTKLYGSSGAMKI 684
|
|
| FtsI |
COG0768 |
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ... |
321-621 |
1.44e-31 |
|
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain] Cd Length: 568 Bit Score: 130.71 E-value: 1.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 321 RELTGEDPATTPMKIYTALDTSTQDRLNDIQEKKVIgmpENKYFQIAASVIDNRKGTIIAIGT--GFD-----DPTSSTY 393
Cdd:COG0768 207 RDLGEEKPPVPGKDLVLTIDSDLQKIAEEALKKAVE---EYKAKSGAVVVMDPKTGEILAMASypSFDpnlfvGGPDEPL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 394 KDRATKEKHQPGSTSKPLLAYAqAFDQiGWAT--SRIVEDKPIQIYGDTKSNYDNKYHGKVSLERALAQSLNIPALEAMQ 471
Cdd:COG0768 284 RNRAVQGTYEPGSTFKPFTAAA-ALEE-GVITpdTTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLAL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 472 AVtnavGNDYMREYMKKLGFDDKV--------------AEKFDLLY----AIG-GanFEATPTQMAAAFATLANGGKYIE 532
Cdd:COG0768 362 RL----GIDKLYDYLKKFGLGQKTgidlpgeasgllpsPKRWYPGEtatmSIGqG--LSVTPLQLAQAYAAIANGGVLVK 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 533 PHMITKVVYKDGSKTYENNAKTTQAMSPQAAYMTSDLLNKAITGKY-SGYNYmsqafNGAGYPVYGKTGTSD-WDDYADE 610
Cdd:COG0768 436 PHLVKEIVDPDGEVVKEEPEVLRRVISPETAETVREGMEGVVNEPGgTARRA-----AIPGYRVAGKTGTAQvVDIGNGG 510
|
330
....*....|.
gi 495963657 611 VGGNAHDGWMV 621
Cdd:COG0768 511 YYKGRHIASFV 521
|
|
| PRK11240 |
PRK11240 |
penicillin-binding protein 1C; Provisional |
92-673 |
1.44e-28 |
|
penicillin-binding protein 1C; Provisional
Pssm-ID: 183049 [Multi-domain] Cd Length: 772 Bit Score: 122.89 E-value: 1.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 92 VEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFINKPKeekadsegikltqk 171
Cdd:PRK11240 65 VTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPR-------------- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 172 dKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALYNPyqg 251
Cdd:PRK11240 131 -TFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYAEAALLAVLPQAPSRLRP--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 252 ydsktkQNYYAYATKRRNETLSLMLSHGYISESEYKLAKatklafqlkgeskaKDNPYLA---YAQAAITEARELTGEDP 328
Cdd:PRK11240 207 ------DRWPERAEAARNKVLERMAEQGVWSAEQVKESR--------------EEPVWLAprqMPQLAPLFARMMLGKSK 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 329 attPMKIYTALDTSTQDRLNDIQEKKVIGMPENKyfQIAASVIDNRKGTIIA-IGT-GFDDPTSSTYKDRATKEKhQPGS 406
Cdd:PRK11240 267 ---SDKIVTTLDAGLQRRLEDLALNWKGRLPPRS--SLAMIVVDHTDMAVRGwVGSvDLNDDSRFGHVDMVNAIR-SPGS 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 407 TSKPLLaYAQAFDQIGWATSRIVEDKPIQiYGDTK-SNYDNKYHGKVSLERALAQSLNIPALEAMQAVTNAVGNDYMREY 485
Cdd:PRK11240 341 VLKPFV-YGLALDDGLIHPASLLQDVPRR-TGDYRpGNFDSGFHGPVSMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNV 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 486 MKKLGFDDKVAEKFDLLYAIGGANFEatptQMAAAFATLANGGKyiephmITKVVYKDGSKTYENnakttQAMSPQAAYM 565
Cdd:PRK11240 419 GLPLYLPAGAEPNLSLILGGAGARLE----DMVAAYSAFARHGK------AAKLRLQPDDPLLER-----PLMSPGAAWI 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 566 TSDLLnkAITGKYSGYNYMSQAFngagyPVYGKTGTSdwddYAdevggnAHDGWMVNYTSDYTIASWNGfdsR-----VN 640
Cdd:PRK11240 484 IRRIM--ADEAQPLPDAALPRVV-----PLAWKTGTS----YG------YRDAWAIGVNARYVIGIWTG---RpdgtpVV 543
|
570 580 590
....*....|....*....|....*....|...
gi 495963657 641 GYTYLSEAVQNMNipgKINRYILDSLSSNATRI 673
Cdd:PRK11240 544 GQFGFASAVPLLN---QVNNLLLSRSSQRGANL 573
|
|
| Transpeptidase |
pfam00905 |
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ... |
366-624 |
2.65e-25 |
|
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain] Cd Length: 296 Bit Score: 107.12 E-value: 2.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 366 IAASVIDNRKGTIIAI-GTGFDDPTS--STYKDRATKEKHQPGSTSKPLLAyAQAFDQIGWATSRIVEDKPIQIYGDT-K 441
Cdd:pfam00905 1 GSAVVLDPKTGEVLAMvGKPSYDPNGfiGPLRNRAVTSRYEPGSTFKPFTA-LAALDNGVLKPDETIFDWPGKQQGGKsI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 442 SNYDNKYHGKVSLERALAQSLNIPaleaMQAVTNAVGNDYMREYMKKLGFDDKVaeKFDLLYAIGGANFE---------- 511
Cdd:pfam00905 80 GDWNQDQVGIGTLRQALEYSSNWY----MQKLAQKLGADKLRSYLKKFGYGNKT--GIGLPGENAGYLTPywlegatasf 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 512 -----ATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSKTYENnakttQAMSPQAAYMTSDLLNKAITGKYSGYnymsq 586
Cdd:pfam00905 154 gigltITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNK-----LPISKSTAEKVKDMLRLVVNDGTGTG----- 223
|
250 260 270
....*....|....*....|....*....|....*....
gi 495963657 587 AFNGAGYPVYGKTGTSD-WDDYADEVGGNAHDGWMVNYT 624
Cdd:pfam00905 224 TAAVPGYKVAGKTGTAQvAGPKGGGYYDGAQIGWFVGYA 262
|
|
| PRK13481 |
PRK13481 |
glycosyltransferase; Provisional |
92-289 |
2.67e-25 |
|
glycosyltransferase; Provisional
Pssm-ID: 184078 [Multi-domain] Cd Length: 232 Bit Score: 105.27 E-value: 2.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 92 VEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSlAQGGSTLTMQTIDNFInkpkeekADSEgikltqk 171
Cdd:PRK13481 48 VSADNMPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTISDRD-VQGGSTITQQVVKNYF-------YDNE------- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 172 DKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFG-------KNVEQLNLSESAFLAGVVNAPA 244
Cdd:PRK13481 113 RSFTRKVKELFVAHRVEKQYSKNEILSFYLNNIYFGDNQYTLEGAANHYFGttvnknsTTMSHITVLQSAILASKVNAPS 192
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 495963657 245 LYNPyqgydSKTKQNYyayaTKRRNETLSLMLSHGYISESEYKLA 289
Cdd:PRK13481 193 VYNI-----NDMSENF----TQRVSTNLEKMKQQNYINETQYQQA 228
|
|
| mono_pep_trsgly |
TIGR02070 |
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ... |
92-246 |
4.83e-21 |
|
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273951 [Multi-domain] Cd Length: 224 Bit Score: 92.91 E-value: 4.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 92 VEYEQIPQVTIDAFLAIEDSRYFKHNGFDLPRFISSAFNNLRSGSLAQGGSTLTMQTIDNFInkpkeekadsegikLTQK 171
Cdd:TIGR02070 58 RPYDQISPNLKRAVIASEDAKFVEHHGFDWEAIQDALEKNEKSGKVVRGGSTISQQLAKNLF--------------LWSG 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495963657 172 DKIEMKIQEIYLSLRLDSKMSKEEILTNYLNKINFGASARGIQKGAQYYFGKNVEQLNLSESAFLAGVVNAPALY 246
Cdd:TIGR02070 124 RSYLRKGLEAWATWMLETWWSKQRILEVYLNSVEWGNGVFGAEAAARYYFKRSASNLTRGQAARLAAVLPNPKYY 198
|
|
| pbp2_mrdA |
TIGR03423 |
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ... |
367-623 |
5.35e-16 |
|
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain] Cd Length: 592 Bit Score: 82.19 E-value: 5.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 367 AASVIDNRKGTIIAIGT--GFDdP-------TSSTYK-----------DRATKEKHQPGSTSKPLLAYAqAFD-QIGWAT 425
Cdd:TIGR03423 250 AVVVMDPRTGEILAMVStpSFD-PnlfvdgiSSKDYKallndpdrpllNRAIQGVYPPGSTFKPVVALA-ALEeGVITPE 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 426 SRIVEDKPIQIYGDTKSNYDNKYHGKVSLERALAQSLNIPALEAMQAVtnavGNDYMREYMKKLGFDDKV-----AEKFD 500
Cdd:TIGR03423 328 TRIYCPGYFQLGGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRL----GIDKIAEYAKRFGFGQKTgidlpGEKSG 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 501 LL---------------------YAIGGANFEATPTQMAAAFATLANGGKYIEPHMITKVVYKDGSK--TYENNAKTTQA 557
Cdd:TIGR03423 404 LVpsrewkrkrfgqpwypgdtlnVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDPDGGVvrRTEPEVLRPLP 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 558 MSPQaaymTSDLLNKAI---------TGKYsgynymsqAFNGAGYPVYGKTGTSDWDDYADEVGGNAHD--------GWM 620
Cdd:TIGR03423 484 ISPE----NLDVVREGMrdvvngpggTARR--------ARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQiperlrdhALF 551
|
...
gi 495963657 621 VNY 623
Cdd:TIGR03423 552 VAF 554
|
|
| FIVAR |
pfam07554 |
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell ... |
712-771 |
3.12e-05 |
|
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as pfam05089 further supports this proposal. It is found in the C-terminal part of Swiss:O82833, which is removed during maturation. Some of the proteins it is found in are involved in methicillin resistance. The name FIVAR derives from Found In Various Architectures.
Pssm-ID: 400096 [Multi-domain] Cd Length: 69 Bit Score: 42.69 E-value: 3.12e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495963657 712 ALKSPISDASKYKQS----DYTPETWAALQEALKQANALLNK---EDVTEDEVNRAKQALENAIRGL 771
Cdd:pfam07554 2 ALKTSINDKNATKTSsnyiNADNDKKAAYNNAITAAKAILNKtnnPNATQEEVNQALTKLNTAINAL 68
|
|
| PqqL |
COG0612 |
Predicted Zn-dependent peptidase, M16 family [General function prediction only]; |
730-835 |
5.71e-04 |
|
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain] Cd Length: 427 Bit Score: 43.37 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495963657 730 PETWAALQEALKQANALLNKEDVTEDEVNRAKQALENA-IRGLKekevavTTTSLTSAIQNAAAYTDTTKYQSAYVQALN 808
Cdd:COG0612 322 PDKLEEALAAILEELERLAKEGVTEEELERAKNQLLGSlALSLE------SNSGLASQLGRYELYGGDLDYLEEYLERIE 395
|
90 100
....*....|....*....|....*..
gi 495963657 809 SrinaanalltssgVTQAEINQAVQDI 835
Cdd:COG0612 396 A-------------VTAEDVQAVARKY 409
|
|
| FIVAR |
pfam07554 |
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell ... |
781-841 |
6.35e-03 |
|
FIVAR domain; This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as pfam05089 further supports this proposal. It is found in the C-terminal part of Swiss:O82833, which is removed during maturation. Some of the proteins it is found in are involved in methicillin resistance. The name FIVAR derives from Found In Various Architectures.
Pssm-ID: 400096 [Multi-domain] Cd Length: 69 Bit Score: 36.14 E-value: 6.35e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495963657 781 TSLTSAIQNAAAYTDTTKYQSAY---VQALNSRINAANALL---TSSGVTQAEINQAVQDIQAAIEA 841
Cdd:pfam07554 1 KALKTSINDKNATKTSSNYINADndkKAAYNNAITAAKAILnktNNPNATQEEVNQALTKLNTAINA 67
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