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Conserved domains on  [gi|496030708|ref|WP_008755215|]
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GNAT family N-acetyltransferase [Lachnoanaerobaculum saburreum]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11447364)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 52-133 7.96e-13

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 62.32  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  52 VFSIFDGEIfLGMIQ--QIRMEKDNVHIGrFIIDPSKQGRGYGKEALKTFIKLIFEEKNINSISLTVFDSNKNAKKVYMG 129
Cdd:COG1670   65 IEDKEDGEL-IGVVGlyDIDRANRSAEIG-YWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEK 142


                 ....
gi 496030708 130 LGFK 133
Cdd:COG1670  143 LGFR 146
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 52-133 7.96e-13

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 62.32  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  52 VFSIFDGEIfLGMIQ--QIRMEKDNVHIGrFIIDPSKQGRGYGKEALKTFIKLIFEEKNINSISLTVFDSNKNAKKVYMG 129
Cdd:COG1670   65 IEDKEDGEL-IGVVGlyDIDRANRSAEIG-YWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEK 142


                 ....
gi 496030708 130 LGFK 133
Cdd:COG1670  143 LGFR 146
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 19-132 3.11e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 3.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708   19 RWSNERGKEFQEQWMGSRISYPLDYEKLKDMENVFSIFDGEIfLGMIQ--QIRMEKDNVHIGRFIIDPSKQGRGYGKEAL 96
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGEL-VGFASlsIIDDEPPVGEIEGLAVAPEYRGKGIGTALL 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 496030708   97 KTFIKlIFEEKNINSISLTVFDSNKNAKKVYMGLGF 132
Cdd:pfam00583  82 QALLE-WARERGCERIFLEVAADNLAAIALYEKLGF 116
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 82-137 8.02e-09

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 51.08  E-value: 8.02e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 496030708  82 IDPSKQGRGYGKEALKTFIKlIFEEKNINSISLTVFDSNKNAKKVYMGLGFkiNEI 137
Cdd:PRK09491  71 VDPDYQRQGLGRALLEHLID-ELEKRGVATLWLEVRASNAAAIALYESLGF--NEV 123
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-115 2.44e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 2.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496030708  52 VFSIFDGEIFLGMIQ--QIRMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKlIFEEKNINSISLT 115
Cdd:cd04301    1 FLVAEDDGEIVGFASlsPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE-EARERGAKRLRLE 65
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 52-133 7.96e-13

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 62.32  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  52 VFSIFDGEIfLGMIQ--QIRMEKDNVHIGrFIIDPSKQGRGYGKEALKTFIKLIFEEKNINSISLTVFDSNKNAKKVYMG 129
Cdd:COG1670   65 IEDKEDGEL-IGVVGlyDIDRANRSAEIG-YWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEK 142


                 ....
gi 496030708 130 LGFK 133
Cdd:COG1670  143 LGFR 146
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 19-132 3.11e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 3.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708   19 RWSNERGKEFQEQWMGSRISYPLDYEKLKDMENVFSIFDGEIfLGMIQ--QIRMEKDNVHIGRFIIDPSKQGRGYGKEAL 96
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGEL-VGFASlsIIDDEPPVGEIEGLAVAPEYRGKGIGTALL 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 496030708   97 KTFIKlIFEEKNINSISLTVFDSNKNAKKVYMGLGF 132
Cdd:pfam00583  82 QALLE-WARERGCERIFLEVAADNLAAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 63-140 1.24e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 54.66  E-value: 1.24e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496030708  63 GMIQ-QIRMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKlIFEEKNINSISLTVFDSNKNAKKVYMGLGFKINEIIET 140
Cdd:COG0456    1 GFALlGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALE-RARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPN 78
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 41-133 6.70e-10

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 53.43  E-value: 6.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708   41 LDYEKLKDMEN-----VFSIFDGEIFLGMIqqiRMeKDNVHIGRFIIDPSKQGRGYGKEALKTFIKLIfEEKNINSISLT 115
Cdd:pfam13673  17 ISPEALRERIDqgeyfFFVAFEGGQIVGVI---AL-RDRGHISLLFVDPDYQGQGIGKALLEAVEDYA-EKDGIKLSELT 91

                          90
                  ....*....|....*...
gi 496030708  116 VfDSNKNAKKVYMGLGFK 133
Cdd:pfam13673  92 V-NASPYAVPFYEKLGFR 108
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 69-149 5.99e-09

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 51.21  E-value: 5.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  69 RMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKLiFEEKNINSISLTVFDSNKNAKKVYMGLGFK-INEIIETPNLKYIM 147
Cdd:COG0454   53 RLDDKVLELKRLYVLPEYRGKGIGKALLEALLEW-ARERGCTALELDTLDGNPAAIRFYERLGFKeIERYVAYVGGEFEK 131


                 ..
gi 496030708 148 KL 149
Cdd:COG0454  132 EL 133
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 82-137 8.02e-09

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 51.08  E-value: 8.02e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 496030708  82 IDPSKQGRGYGKEALKTFIKlIFEEKNINSISLTVFDSNKNAKKVYMGLGFkiNEI 137
Cdd:PRK09491  71 VDPDYQRQGLGRALLEHLID-ELEKRGVATLWLEVRASNAAAIALYESLGF--NEV 123
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-133 5.88e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 48.50  E-value: 5.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708   53 FSIFD-GEIFLGMI--QQIRMEKDNVHIGrFIIDPSKQGRGYGKEALKTFIKLIFEEKNINSISLTVFDSNKNAKKVYMG 129
Cdd:pfam13302  57 WAIELkDTGFIGSIglYDIDGEPERAELG-YWLGPDYWGKGYATEAVRALLEYAFEELGLPRLVARIDPENTASRRVLEK 135


                  ....
gi 496030708  130 LGFK 133
Cdd:pfam13302 136 LGFK 139
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
53-141 1.04e-05

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443180  Cd Length: 170  Bit Score: 42.98  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  53 FSIFDGEIFLGMIQqIRMEKDNV------HIGrFIIDPSKQGRGYGKEALKtFIKLIFEEKNINSISLTVFDSNKNAKKV 126
Cdd:COG3981   66 WLVDEDGRIVGAIN-LRHELNEFllrvggHIG-YGVRPSERGKGYATEMLR-LALEEARELGLDRVLITCDKDNIASRKV 142

                         90
                 ....*....|....*
gi 496030708 127 YMGLGFKINEIIETP 141
Cdd:COG3981  143 IEANGGVLEDEVVDE 157
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
63-133 1.71e-05

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 41.05  E-value: 1.71e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496030708  63 GMIQQIRMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKLIFEEkNINSISLTVFDSNKNAKKVYMGLGFK 133
Cdd:COG3393    4 AMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALAR-GARTPFLYVDADNPAARRLYERLGFR 73
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-115 2.44e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 2.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496030708  52 VFSIFDGEIFLGMIQ--QIRMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKlIFEEKNINSISLT 115
Cdd:cd04301    1 FLVAEDDGEIVGFASlsPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE-EARERGAKRLRLE 65
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
80-134 3.89e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 41.52  E-value: 3.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 496030708  80 FIIDPSKQGRGYGKEALKTFIKlIFEEKNINSISLTVFDSNKNAKKVYMGLGFKI 134
Cdd:COG1247   86 IYVDPDARGRGIGRALLEALIE-RARARGYRRLVAVVLADNEASIALYEKLGFEE 139
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 57-141 2.79e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 38.43  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  57 DGEIfLGMIQQIRMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKlIFEEKNINSISLtvfDSNKNAKKVYMGLGFKINE 136
Cdd:COG1246   36 DGEI-VGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLA-EARELGLKRLFL---LTTSAAIHFYEKLGFEEID 110


                 ....*
gi 496030708 137 IIETP 141
Cdd:COG1246  111 KEDLP 115
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
71-134 7.38e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 37.47  E-value: 7.38e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496030708  71 EKDNVHIGRFIIDPSKQGRGYGKEALKTFIKLIfEEKNINSISLtvfDSNKNAKKVYMGLGFKI 134
Cdd:COG2153   55 GDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEA-RERGARRIVL---SAQAHAVGFYEKLGFVP 114
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 50-134 7.78e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 36.28  E-value: 7.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708   50 ENVFSIFDGEIFLGMIQ-QIRMEKDNVHIGRFIIDPSKQGRGYGKeALktfIKLIFEEKNINSISLTVFDSNKNAKKVYM 128
Cdd:pfam13508   3 GRFFVAEDDGKIVGFAAlLPLDDEGALAELRLAVHPEYRGQGIGR-AL---LEAAEAAAKEGGIKLLELETTNRAAAFYE 78


                  ....*.
gi 496030708  129 GLGFKI 134
Cdd:pfam13508  79 KLGFEE 84
PRK15130 PRK15130
spermidine N1-acetyltransferase; Provisional
 76-134 1.67e-03

spermidine N1-acetyltransferase; Provisional


Pssm-ID: 237916  Cd Length: 186  Bit Score: 37.08  E-value: 1.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496030708  76 HIGR-----FIIDPSKQGRGYGKEALKTFIKLIFEEKNINSISLTVFDSNKNAKKVYMGLGFKI 134
Cdd:PRK15130  79 HVHRraefqIIISPEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFEV 142
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
57-149 3.12e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 35.83  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496030708  57 DGEIfLGMIQ----QIRMEKDNVHIGRFIIDPSKQGRGYGKEALKTFIKLiFEEKNINSISLTvfdSNKNAKKVYMGLGF 132
Cdd:COG3153   47 DGEI-VGHVAlspvDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEA-ARERGARAVVLL---GDPSLLPFYERFGF 121

                         90
                 ....*....|....*....
gi 496030708 133 KI--NEIIETPNLKYIMKL 149
Cdd:COG3153  122 RPagELGLTLGPDEVFLAK 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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