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Conserved domains on  [gi|498035486|ref|WP_010349642|]
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ornithine carbamoyltransferase [Paenibacillus peoriae]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479232)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

CATH:  3.40.50.720
EC:  2.1.3.3
Gene Ontology:  GO:0004585|GO:0006591|GO:0006526
PubMed:  18062991

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 11-317 0e+00

ornithine carbamoyltransferase; Provisional


:

Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 607.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 171 GNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAAsreIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKE 250
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498035486 251 RELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALL 317
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 11-317 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 607.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 171 GNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAAsreIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKE 250
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498035486 251 RELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALL 317
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 10-318 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 604.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  10 VNLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 170 DGNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQK 249
Cdd:COG0078  161 DGNNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498035486 250 ERELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:COG0078  241 ERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLG 309
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 15-318 5.45e-174

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 483.78  E-value: 5.45e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   15 RDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGNNM 174
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  175 AHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKERELA 254
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498035486  255 FADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
16-155 5.30e-81

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 241.95  E-value: 5.30e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   16 DFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGRG 95
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   96 EPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYE 155
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 11-317 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 607.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 171 GNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAAsreIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKE 250
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498035486 251 RELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALL 317
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 10-318 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 604.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  10 VNLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 170 DGNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQK 249
Cdd:COG0078  161 DGNNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498035486 250 ERELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:COG0078  241 ERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLG 309
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 15-318 5.45e-174

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 483.78  E-value: 5.45e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   15 RDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGNNM 174
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  175 AHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKERELA 254
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498035486  255 FADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 10-318 3.63e-170

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 475.14  E-value: 3.63e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  10 VNLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PRK02102   3 FNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPND 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:PRK02102  83 SQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHFGPLKGLKLAYVG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 170 DG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ 248
Cdd:PRK02102 163 DGrNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEEDEW 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 249 KERELAFADFQVNEELVQL-AKPDYLFLHCLPA-----------------HRGEEVSAGVIDGPNSVIFDEAENRLHAQK 310
Cdd:PRK02102 243 EERIKLLKPYQVNMDLMKAtGNPDVIFMHCLPAfhdtetkvgkeiaekygLKGLEVTDEVFESKYSIVFDEAENRMHTIK 322


                 ....*...
gi 498035486 311 ALLVALLG 318
Cdd:PRK02102 323 AVMVATLG 330
PLN02342 PLN02342
ornithine carbamoyltransferase
 11-318 1.95e-152

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 431.14  E-value: 1.95e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGE-TYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PLN02342  42 KSKPKHFLHIDDFDKEEILGLLDRAKEVKALLKSGDrSFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:PLN02342 122 IQLGKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLEGTKVVYVG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 170 DGNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVaasrEIAKQTG-SEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ 248
Cdd:PLN02342 202 DGNNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTV----EKARAAGiSKIEITNDPAEAVKGADVVYTDVWASMGQKEEA 277

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 249 KERELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:PLN02342 278 EKRKKAFQGFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAIMLHQLG 347
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 15-318 8.26e-126

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 361.70  E-value: 8.26e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  15 RDFLELDDYSAEEIQYLIDLAIEIKrkhKNGETY-QPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLG 93
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIK---ANPAEYrQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  94 RGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGNN 173
Cdd:PRK14805  79 KRESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVSKVKLAYVGDGNN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 174 MAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITqSPQEAVKDADAIYTDVWASMGFEEEQKEREL 253
Cdd:PRK14805 159 VTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLT-SDIEAIEGHDAIYTDTWISMGDDTPLAEIKA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498035486 254 AFADFQVNEELVQLAKPDYlFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:PRK14805 238 KFAPYQVNKALMEKAGATF-VMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVLVTLLS 301
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 9-318 6.96e-111

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 325.16  E-value: 6.96e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   9 QVNLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKN 88
Cdd:PRK04284   1 MKNLRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  89 DIQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQ-KGKLKGLKLAY 167
Cdd:PRK04284  81 GSQMGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHlKKPYKDIKFTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 168 IGDG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEE 246
Cdd:PRK04284 161 VGDGrNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 247 EQ-KERELAFADFQVNEELVQLAK-PDYLFLHCLPA-H----------------RGEEVSAGVIDGPNSVIFDEAENRLH 307
Cdd:PRK04284 241 EVwEERIKLLKPYQVNKEMMKKTGnPNAIFEHCLPSfHdldtkvgkeifekyglKEMEVTDEVFESKASVVFDEAENRMH 320

                        330
                 ....*....|.
gi 498035486 308 AQKALLVALLG 318
Cdd:PRK04284 321 TIKAVMVATLG 331
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 15-317 7.21e-101

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 299.71  E-value: 7.21e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  15 RDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:PRK03515   7 RHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQ-KGK-LKGLKLAYIGDG- 171
Cdd:PRK03515  87 KESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKaFNEMTLAYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 172 NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ-KE 250
Cdd:PRK03515 167 NNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKEVwAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 251 RELAFADFQVNEELVQLA-KPDYLFLHCLPA------------------HRGEEVSAGVIDGPNSVIFDEAENRLHAQKA 311
Cdd:PRK03515 247 RIALLRPYQVNSKMMQLTgNPQVKFLHCLPAfhddqttlgkkmaeeyglHGGMEVTDEVFESAHSIVFDQAENRLHTIKA 326


                 ....*.
gi 498035486 312 LLVALL 317
Cdd:PRK03515 327 VMVATL 332
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 11-317 1.16e-89

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 271.09  E-value: 1.16e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK01713   4 NLKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGK-LKGLKLAYIG 169
Cdd:PRK01713  84 QIGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCDKpLSEISYVYIG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 170 DG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFE-EE 247
Cdd:PRK01713 164 DArNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEPlET 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 248 QKERELAFADFQVNEELVQ-LAKPDYLFLHCLPA-HRGE------------------EVSAGVIDGPNSVIFDEAENRLH 307
Cdd:PRK01713 244 WGERIKLLMPYQVTPELMKrTGNPKVKFMHCLPAfHNSEtkvgrqiaekypelangiEVTEDVFESPMNIAFEQAENRMH 323

                        330
                 ....*....|
gi 498035486 308 AQKALLVALL 317
Cdd:PRK01713 324 TIKAVMVASL 333
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
16-155 5.30e-81

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 241.95  E-value: 5.30e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   16 DFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGRG 95
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   96 EPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYE 155
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
164-316 5.37e-80

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 239.82  E-value: 5.37e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  164 KLAYIGDG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASM 242
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498035486  243 GFEEEQKERELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVAL 316
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 15-318 1.21e-79

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 245.35  E-value: 1.21e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  15 RDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:PRK12562   7 KHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQ-KGK-LKGLKLAYIGDG- 171
Cdd:PRK12562  87 KESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKaFNEMTLVYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 172 NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAASREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ-KE 250
Cdd:PRK12562 167 NNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPKEKwAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 251 RELAFADFQVNEELVQLA-KPDYLFLHCLPA------------------HRGEEVSAGVIDGPNSVIFDEAENRLHAQKA 311
Cdd:PRK12562 247 RIALLRGYQVNSKMMALTgNPQVKFLHCLPAfhddqttlgkkmakefglHGGMEVTDEVFESPASIVFDQAENRMHTIKA 326


                 ....*..
gi 498035486 312 LLVALLG 318
Cdd:PRK12562 327 VMVATLA 333
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 15-318 4.00e-70

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 221.16  E-value: 4.00e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  15 RDFLELDDYSAEEIQYLIDLAieikRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFL-SKND---I 90
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQA----AAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLqPGKDawpI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  91 QLGRG--------EPISDMAQVMSRYLDGIMIRTFG---------HDNVVE-LARYASVPVINgLSDLAHPCQVLADYQT 152
Cdd:PRK04523  80 EFELGavmdgeteEHIREVARVLSRYVDLIGVRAFPkfvdwskdrQDQVLNsFAKYSTVPVIN-METITHPCQELAHALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 153 LYEQKGK-LKGLKL----AYIGDGNNMA--HSLLIGGAKLGVHVSIASP-AGYEPDPSVVAASREIAKQTGSEIVITQSP 224
Cdd:PRK04523 159 LQEHFGTtLRGKKYvltwTYHPKPLNTAvaNSALLIATRLGMDVTLLCPtPDYILDERYMDWAEQNAAESGGSLTVSHDI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 225 QEAVKDADAIYTDVWASMGF---EEEQKERELAFADFQVNEELVQLAKpDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDE 301
Cdd:PRK04523 239 DSAYAGADVVYAKSWGALPFfgnWEPEKPIRDQYQHFIVDERKMALTN-NGVFSHCLPLRRNVKVTDAVMDSPNCIAIDE 317

                        330
                 ....*....|....*..
gi 498035486 302 AENRLHAQKALLVALLG 318
Cdd:PRK04523 318 AENRLHVQKAIMAALAS 334
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 1-317 4.72e-65

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 207.19  E-value: 4.72e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   1 MSQSGALHQVNLKgrdfleldDYSAEEIQYLIDLAIEIKRKHKNGETYqpLQGKTLGLIFEKSSTRTRVSFEVGMYQLGG 80
Cdd:PRK14804   1 MSESNVKHLISWE--------DWSDSEILDLLDFAVHVKKNRVNYAGH--MSGRSLAMLFQKTSTRTRVSFEVAMTEMGG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  81 HALFLS--KNDIQLgrgEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKG 158
Cdd:PRK14804  71 HGIYLDwmASNFQL---SDIDLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIALDSP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 159 K--LKGLKLAYIGDGNNMAHSLLIGGAKLGVHVSIASPAGYEpdPSVVAASREIAKQTGSeIVITQSPQEAVKDADAIYT 236
Cdd:PRK14804 148 EipLNQKQLTYIGVHNNVVNSLIGITAALGIHLTLVTPIAAK--ENIHAQTVERAKKKGT-LSWEMNLHKAVSHADYVYT 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 237 DVWASMGF------EEEQKERELAFADFQVNEELVQlaKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQK 310
Cdd:PRK14804 225 DTWLDMEFfndpsyADKKKQRMELMMPYQINSSLME--KTNAKVMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQK 302


                 ....*..
gi 498035486 311 ALLVALL 317
Cdd:PRK14804 303 AVILKLL 309
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 11-318 7.22e-59

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 191.04  E-value: 7.22e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:COG0540    2 SFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  91 QLGRGEPISDMAQVMSRY-LDGIMIRTfGHDNVV-ELARYASVPVINGlSD--LAHPCQVLADYQTLYEQKGKLKGLKLA 166
Cdd:COG0540   82 SVSKGESLADTIRTLEAYgADAIVIRH-PQEGAArLLAEHVDVPVINA-GDgaHEHPTQALLDLYTIREEFGRLDGLKVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 167 YIGDGNNM--AHSLLIGGAKLGVHVSIASPAGYEPDpsvvaasrEIAKqtgSEIVITQSPQEAVKDADAIY-TDVwasmg 243
Cdd:COG0540  160 IVGDLKHSrvARSNIKALSKLGAEVTLVAPPTLLPE--------EIEE---LGVEVTTDLDEALPDADVVYmLRI----- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 244 feeeQKER---------ELAFADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLV 314
Cdd:COG0540  224 ----QKERftdglfpsyREYKRSYGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLY 299


                 ....
gi 498035486 315 ALLG 318
Cdd:COG0540  300 LLLG 303
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
11-318 5.82e-53

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 175.65  E-value: 5.82e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQP-LQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PRK00856   2 PLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKVPlLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  90 IQLGRGEPISDMAQVMSRYL-DGIMIRtfgHDN---VVELARYASVPVIN---GLSdlAHPCQVLADYQTLYEQKGKLKG 162
Cdd:PRK00856  82 SSVSKGETLADTIRTLSAMGaDAIVIR---HPQsgaARLLAESSDVPVINagdGSH--QHPTQALLDLLTIREEFGRLEG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 163 LKLAYIGDGNN--MAHSLLIGGAKLGVHVSIASPAGYEPDpsvvaasrEIAKQTgseivITQSPQEAVKDADAIY-TDVw 239
Cdd:PRK00856 157 LKVAIVGDIKHsrVARSNIQALTRLGAEVRLIAPPTLLPE--------GMPEYG-----VHTDLDEVIEDADVVMmLRV- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 240 asmgfeeeQKER-------ELA--FADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQK 310
Cdd:PRK00856 223 --------QKERmdggllpSYEeyKRSYGLTAERLALAKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRM 294


                 ....*...
gi 498035486 311 ALLVALLG 318
Cdd:PRK00856 295 AVLELLLG 302
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 15-318 1.44e-43

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 151.36  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   15 RDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND-IQLG 93
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSEtSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   94 RGEPISDMAQVMSRYLDGIMIRTfghdNVVELARYAS----VPVIN-GLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYI 168
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRH----PLEGAARLAAevseVPVINaGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  169 GDGNN--MAHSLLIGGAKLGVHVSIASpagyepdPSVVAASREI---AKQTGSEIVITQSPQEAVKDADAIYtdvwasmg 243
Cdd:TIGR00670 157 GDLKYgrTVHSLAEALTRFGVEVYLIS-------PEELRMPKEIleeLKAKGIKVRETESLEEVIDEADVLY-------- 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  244 FEEEQKERELAFAD-------FQVNEELVQLAKPDYLFLHCLPahRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVAL 316
Cdd:TIGR00670 222 VTRIQKERFPDPEEyekvkgsYGITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALL 299


                  ..
gi 498035486  317 LG 318
Cdd:TIGR00670 300 LG 301
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 24-318 1.31e-29

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 116.89  E-value: 1.31e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  24 SAEEIQYLIDLAIEIKRKHKNGETyqpLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALflSKNDIQ---LGRGEPISD 100
Cdd:PRK11891 100 SVEALFRVADVMQPIARRQKISRV---LEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVC--DTTGFTfssMAKGESIYD 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 101 MAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLA-HPCQVLADYQTL---YEQKGKL-KGLKLAYIGD--GNN 173
Cdd:PRK11891 175 TSRVMSGYVDALVIRHPEQGSVAEFARATNLPVINGGDGPGeHPSQALLDLYTIqreFSRLGKIvDGAHIALVGDlkYGR 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 174 MAHSLLiggaKL-----GVHVSIASPAGYEPDPSVVaasrEIAKQTGSEIVITQSPQEAVKDADAIY-TDVwasmgfeee 247
Cdd:PRK11891 255 TVHSLV----KLlalyrGLKFTLVSPPTLEMPAYIV----EQISRNGHVIEQTDDLAAGLRGADVVYaTRI--------- 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 248 QKER------ELAFADFQVNEELVQLA-KPDYLFLHCLPAHR---GEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALL 317
Cdd:PRK11891 318 QKERfadesfEGYTPDFQINQALVDAVcKPDTLIMHPLPRDSrpgANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLL 397


                 .
gi 498035486 318 G 318
Cdd:PRK11891 398 G 398
PLN02527 PLN02527
aspartate carbamoyltransferase
 16-318 1.19e-28

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 112.15  E-value: 1.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  16 DFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFL--SKNDIQLG 93
Cdd:PLN02527   2 DVIEAQQFDREMLELLFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTenAGEFSSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  94 RGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVIN-GLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGN 172
Cdd:PLN02527  82 KGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGDLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 173 N--MAHSLliggAKL-----GVHVSIASPAGYE--PDPSVVAASREIAKQTGSEIVitqspqEAVKDADAIYTDVWASMG 243
Cdd:PLN02527 162 NgrTVRSL----AYLlakyeDVKIYFVAPDVVKmkDDIKDYLTSKGVEWEESSDLM------EVASKCDVLYQTRIQRER 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498035486 244 FEEEQKERELAFADFQVNEELVQLAKPDYLFLHCLPahRGEEVSAGVIDGPNSVIFDEAENRLHAQKALLVALLG 318
Cdd:PLN02527 232 FGERIDLYEAARGKYIVDKKVMDVLPKHAVVMHPLP--RLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLLG 304
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 11-318 1.02e-22

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 96.33  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHAL----FLS 86
Cdd:PRK08192   2 QFQGSHILSVNQLDRDAIQRIFNVADRMEPYALREKRTRVLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHVRettgMAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  87 KNdiqLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGlSDLA--HPCQVLADYQTLYEQ---KGK-L 160
Cdd:PRK08192  82 SS---LSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVING-GDGSneHPTQALLDLFTIQKElahAGRgI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 161 KGLKLAYIGDGNN--MAHSL--LIGGAKlGVHVSIASPAGYEPDPSVVAASReiakQTGSEIVITQSPQEAVKDADAIYt 236
Cdd:PRK08192 158 DGMHIAMVGDLKFgrTVHSLsrLLCMYK-NVSFTLVSPKELAMPDYVISDIE----NAGHKITITDQLEGNLDKADILY- 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 237 dvwaSMGFEEE----QKERELAFADFQVNEEL-VQLAKPDYLFLHCLPA-HRGE--EVSAGVIDGPNSVIFDEAENRLHA 308
Cdd:PRK08192 232 ----LTRIQEErfpsQEEANKYRGKFRLNQSIyTQHCKSNTVIMHPLPRdSRAQanELDNDLNSHPNLAIFRQADNGLLI 307

                        330
                 ....*....|
gi 498035486 309 QKALLVALLG 318
Cdd:PRK08192 308 RMALFALTLG 317
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 11-292 4.46e-22

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 95.19  E-value: 4.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAiEIKRKHKNGETYQPLQGKTLGL-IFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PRK07200  17 HMHEKDFLLTWEKTPDELKAVLDVA-DALRALREENISTKVFNSGLGIsVFRDNSTRTRFSYASACNLLGLEVQDLDEGK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  90 IQLGRGEPISDMAQVMSRYLDGIMIR-------------------TFGHDNVVELARYAsvpVINGLSDLAHPCQVLADY 150
Cdd:PRK07200  96 SQIAHGETVRETANMISFMADVIGIRddmyigkgnaymrevgaavDDGYKQGVLPQRPT---LVNLQCDIDHPTQSMADL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 151 QTLYEQKG---KLKGLKLAYigdgnNMAHSL-----------LIG-GAKLGVHVSIASPAGYEPDPSVVAASREIAKQTG 215
Cdd:PRK07200 173 LHLIEHFGgleNLKGKKIAM-----TWAYSPsygkplsvpqgIIGlMTRFGMDVTLAHPEGYDLMPEVVEVAKKNAKASG 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 216 SEIVITQSPQEAVKDADAIYTDVWASMGFEEEQK--------------EREL-----AFADFQVNEELVQLAKP-DYLFL 275
Cdd:PRK07200 248 GSFRQVNSMEEAFKDADIVYPKSWAPYKVMEERTelyragdhegikalEKELlaqnaQHKDWHCTEEMMKLTKDgKALYM 327

                        330       340
                 ....*....|....*....|...
gi 498035486 276 HCLPAH------RGEEVSAGVID 292
Cdd:PRK07200 328 HCLPADisgvscKEGEVTESVFD 350
pyrB PRK13814
aspartate carbamoyltransferase;
7-317 1.39e-14

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 72.83  E-value: 1.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486   7 LHQVNLKG--RDFLElddYSAEEIQYLIDLAIEikrkhKNgETYQPLQGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALF 84
Cdd:PRK13814   6 LHLLNMRSltRDHIE---KLIQRANYFLTQGME-----KN-SVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  85 LSKNDIQLGRGEPISDMA---QVMSRYLdgIMIRTFGHDNVVELARYASVPVI--NGLSDLAHPCQVLADYQTLYEQKGK 159
Cdd:PRK13814  77 PNLKISAISKGETLFDTIktlEAMGVYF--FIVRHSENETPEQIAKQLSSGVVinAGDGNHQHPSQALIDLMTIKQHKPH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 160 LKGLKLAYIGD--GNNMAHSLLIGGAKLGV-HVSIASPAGYEPDPsvvAASREIAKQTGSEIVITQSpqeavkdadaiyt 236
Cdd:PRK13814 155 WNKLCVTIIGDirHSRVANSLMDGLVTMGVpEIRLVGPSSLLPDK---VGNDSIKKFTELKPSLLNS------------- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 237 DVWASMGFEEEQKEREL---AF-ADFQVNEELVQLAKPDYLFLHCLPAHRGEEVSAGVIDGPNSVIFDEAENRLHAQKAL 312
Cdd:PRK13814 219 DVIVTLRLQKERHDNSVdidAFrGSFRLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAV 298


                 ....*
gi 498035486 313 LVALL 317
Cdd:PRK13814 299 LELFL 303
pyrB PRK13376
bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase ...
 11-282 1.11e-03

bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional


Pssm-ID: 237369 [Multi-domain]  Cd Length: 525  Bit Score: 40.51  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  11 NLKGRDFLELDDYSAEEIQYLIDLAIEIKRKHKNGETYQPLQ--GKTLGL--IFEKSSTRTRVSF-EVGMYQLGGHALFL 85
Cdd:PRK13376   4 DFLGRTLAVIEDLSVEEQLFLYEKTRELKQRWYEGEDVSEFRikKRDVGIyiVFVEPSTRTKESFiNAAKFHKNVKVNIF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486  86 SKNDIQLGRGEPISDMAQVMSRYLDG--IMIRT-------FGHDNVVELARYASVPV---IN-GLSDLAHPCQVLADYQT 152
Cdd:PRK13376  84 DSEHSSFNKQESYTDTFNMLTGYSDYsiFIVRTrlegvcrLLEEKVSEFASRNGIEVpafINaGDGKHEHPTQELLDEFT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035486 153 LYEQKG-KLKGLKLAYIGD--GNNMAHSlLIGGAKL--GVHVSIASPAGYEPDPSVVaasrEIAKQTGSEIVITQSPQEA 227
Cdd:PRK13376 164 FLEQNNfDNSFIHIALVGDllHGRTVHS-KVNGLKIfkNVKVDLIAPEELAMPEHYV----EKMKKNGFEVRIFSSIEEY 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498035486 228 VKDADAiyTDVW-------ASMGFEEEQKERELAFAdFQVNEELVQLAKPDYLFLHCLPAHR 282
Cdd:PRK13376 239 LSQKDV--AKIWyftrlqlERMGEDILEKEHILRKA-VTFRKEFLDKLPEGVKFYHPLPRHK 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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