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Conserved domains on  [gi|499309564|ref|WP_011000339|]
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MULTISPECIES: OsmC family protein [Ralstonia]

Protein Classification

OsmC family protein( domain architecture ID 10004485)

OsmC (osmotically inducible protein C) family protein may function as a peroxiredoxin or hydroperoxide reductase, catalyzing the reduction of organic and inorganic peroxide substrates to protect the cell against oxidative stress

CATH:  3.30.300.20
EC:  1.11.1.-
Gene Ontology:  GO:0004601|GO:0006979
PubMed:  11429455|28391181
SCOP:  4003336

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhfA COG1765
Uncharacterized OsmC-related protein [General function prediction only];
26-126 9.15e-25

Uncharacterized OsmC-related protein [General function prediction only];


:

Pssm-ID: 441371  Cd Length: 126  Bit Score: 91.45  E-value: 9.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564  26 TDVPKPT-GEGSAPDPHAYFDAALACCKTLTVTLYARQRKYPLESIEVAVEHDGSQERQGHYKLRTVLTLHGDLTDEQRA 104
Cdd:COG1765   20 IDEPPELgGTDTGPSPVELLLAALAGCTAITVRMIAKKKGIDLEGLEVEVEGDRDEEPKGFTKIRVTITVDGDLSEEQLE 99

                         90       100
                 ....*....|....*....|....*.
gi 499309564 105 DLLRVAGK-CPIHKLM---TEVEVSI 126
Cdd:COG1765  100 RLLELAEKyCPVSDTLrngVEITTEL 125
 
Name Accession Description Interval E-value
YhfA COG1765
Uncharacterized OsmC-related protein [General function prediction only];
26-126 9.15e-25

Uncharacterized OsmC-related protein [General function prediction only];


Pssm-ID: 441371  Cd Length: 126  Bit Score: 91.45  E-value: 9.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564  26 TDVPKPT-GEGSAPDPHAYFDAALACCKTLTVTLYARQRKYPLESIEVAVEHDGSQERQGHYKLRTVLTLHGDLTDEQRA 104
Cdd:COG1765   20 IDEPPELgGTDTGPSPVELLLAALAGCTAITVRMIAKKKGIDLEGLEVEVEGDRDEEPKGFTKIRVTITVDGDLSEEQLE 99

                         90       100
                 ....*....|....*....|....*.
gi 499309564 105 DLLRVAGK-CPIHKLM---TEVEVSI 126
Cdd:COG1765  100 RLLELAEKyCPVSDTLrngVEITTEL 125
OsmC pfam02566
OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found ...
 33-127 6.41e-17

OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.


Pssm-ID: 460594  Cd Length: 99  Bit Score: 70.43  E-value: 6.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564   33 GEGSAPDPHAYFDAALACCKTLTVTLYARQRKYPLESIEVAVEHDGSQERQ-GHYKLRTVLTLH-GDLTDEQRADLLR-V 109
Cdd:pfam02566   1 GDGSGPNPEELLLAALASCFAITLRAIAKKKGIKLEDLEVEVEGERDPEGAlGFTEIRLRVEVKtPDADEEKLKKLLElA 80

                          90
                  ....*....|....*....
gi 499309564  110 AGKCPIHK-LMTEVEVSID 127
Cdd:pfam02566  81 EKKCPVANtLKNGIKVELE 99
OsmC_like_Se NF041052
OsmC-related (seleno)protein; Members of this family are distantly related to the ...
 33-126 7.58e-06

OsmC-related (seleno)protein; Members of this family are distantly related to the hydroperoxide resistance protein OsmC (osmotically inducible protein) of Escherichia. Proteins found by the HMM include large numbers of selenoproteins, most of which currently are known only from Metagenome-Assembled Genomes (MAGs) of uncultured organisms, a large fraction of which are assigned to the Chloroflexi.


Pssm-ID: 468980  Cd Length: 144  Bit Score: 42.59  E-value: 7.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564  33 GEGSAPDPHAYFDAALAcCKTLT-VTLYARQRKYPLESIEVAVE----HDGSQERQ----GHYKLRTVLTLHGDLTDEQR 103
Cdd:NF041052  35 GTDTAPSPLAYFAAGIA-FULLTqLSRYAHMLKVPIDSAKVEVRarfdRGGSVLGGtveaGCDGVETELEIESDAPPEKV 113

                         90       100
                 ....*....|....*....|....*
gi 499309564 104 ADLLRVAGK-CPIHKLMTE-VEVSI 126
Cdd:NF041052 114 RELVRNAERgCFAEQTLRNpVPVET 138
 
Name Accession Description Interval E-value
YhfA COG1765
Uncharacterized OsmC-related protein [General function prediction only];
26-126 9.15e-25

Uncharacterized OsmC-related protein [General function prediction only];


Pssm-ID: 441371  Cd Length: 126  Bit Score: 91.45  E-value: 9.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564  26 TDVPKPT-GEGSAPDPHAYFDAALACCKTLTVTLYARQRKYPLESIEVAVEHDGSQERQGHYKLRTVLTLHGDLTDEQRA 104
Cdd:COG1765   20 IDEPPELgGTDTGPSPVELLLAALAGCTAITVRMIAKKKGIDLEGLEVEVEGDRDEEPKGFTKIRVTITVDGDLSEEQLE 99

                         90       100
                 ....*....|....*....|....*.
gi 499309564 105 DLLRVAGK-CPIHKLM---TEVEVSI 126
Cdd:COG1765  100 RLLELAEKyCPVSDTLrngVEITTEL 125
OsmC pfam02566
OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found ...
 33-127 6.41e-17

OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.


Pssm-ID: 460594  Cd Length: 99  Bit Score: 70.43  E-value: 6.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564   33 GEGSAPDPHAYFDAALACCKTLTVTLYARQRKYPLESIEVAVEHDGSQERQ-GHYKLRTVLTLH-GDLTDEQRADLLR-V 109
Cdd:pfam02566   1 GDGSGPNPEELLLAALASCFAITLRAIAKKKGIKLEDLEVEVEGERDPEGAlGFTEIRLRVEVKtPDADEEKLKKLLElA 80

                          90
                  ....*....|....*....
gi 499309564  110 AGKCPIHK-LMTEVEVSID 127
Cdd:pfam02566  81 EKKCPVANtLKNGIKVELE 99
OsmC COG1764
Organic hydroperoxide reductase OsmC/OhrA [Defense mechanisms];
33-126 2.16e-06

Organic hydroperoxide reductase OsmC/OhrA [Defense mechanisms];


Pssm-ID: 441370  Cd Length: 140  Bit Score: 44.05  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564  33 GEGSAPDPHAYFDAALACCKTLTVTLYARQRKYPLESIEVAVEHDGSQERQGHYKLRTV-LTLHGDLTDEQRADLLRVAG 111
Cdd:COG1764   39 GDGTGTNPEELLAAAYAACFMLALLAVAAQAGVTVESYEVTAEVTLGKDDDGGFAFTGItLRLRVTVPGLDREKAEELVE 118

                         90       100
                 ....*....|....*....|
gi 499309564 112 K----CPIHKLM-TEVEVSI 126
Cdd:COG1764  119 KahevCPISNALrGNITVEL 138
OsmC_like_Se NF041052
OsmC-related (seleno)protein; Members of this family are distantly related to the ...
 33-126 7.58e-06

OsmC-related (seleno)protein; Members of this family are distantly related to the hydroperoxide resistance protein OsmC (osmotically inducible protein) of Escherichia. Proteins found by the HMM include large numbers of selenoproteins, most of which currently are known only from Metagenome-Assembled Genomes (MAGs) of uncultured organisms, a large fraction of which are assigned to the Chloroflexi.


Pssm-ID: 468980  Cd Length: 144  Bit Score: 42.59  E-value: 7.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499309564  33 GEGSAPDPHAYFDAALAcCKTLT-VTLYARQRKYPLESIEVAVE----HDGSQERQ----GHYKLRTVLTLHGDLTDEQR 103
Cdd:NF041052  35 GTDTAPSPLAYFAAGIA-FULLTqLSRYAHMLKVPIDSAKVEVRarfdRGGSVLGGtveaGCDGVETELEIESDAPPEKV 113

                         90       100
                 ....*....|....*....|....*
gi 499309564 104 ADLLRVAGK-CPIHKLMTE-VEVSI 126
Cdd:NF041052 114 RELVRNAERgCFAEQTLRNpVPVET 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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