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Conserved domains on  [gi|500160075|ref|WP_011834745|]
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1,4-dihydroxy-2-naphthoate polyprenyltransferase [Lactococcus cremoris]

Protein Classification

prenyltransferase( domain architecture ID 10793797)

prenyltransferase transfers an isoprenyl group to an aromatic substrate acceptor; may be involved in the biosynthesis of menaquinone or phylloquinone

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK13387 PRK13387
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional
1-318 2.00e-139

1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional


:

Pssm-ID: 237373  Cd Length: 317  Bit Score: 396.85  E-value: 2.00e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   1 MSLKSFLELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKDE-NYKKQENII 79
Cdd:PRK13387   1 MSAKLFLKLVEIHTKIASFFPVILGTLFSLYVAKIFDWLLFLAFMVAMLAFDIATTAINNYMDFKKALDTaDYVGIGNGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  80 GQANLSTNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVI 159
Cdd:PRK13387  81 GQHGLKPRNVLTVILLMYVVAAILGVYLCMNTSWLLLVIGLICFAIGILYTGGPLPLSRMPLGEIFSGLTMGFGIFLLAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 160 LINTSQDPIFSLNFdfTNNTFSLNGSIFAAIAMIIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLF 239
Cdd:PRK13387 161 YINTNTITIESLLF--QGEMFTIQGNLIAIIAIGVISLPIIFTIANIMLANNLRDLDEDIKNHRYTLVYYIGREKGVVLF 238
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500160075 240 QILMYASYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHEHQVPSPRSFVYSLRNMVLFNSAYAFSLLLSIIWQYLT 318
Cdd:PRK13387 239 AILFYASYLAIAVIVLMGYISPWALLSFLTLRKPISNLQSFQKEAKDPKYFVIAIRNTVLTNTTFGFLLSASLLIQYLF 317
 
Name Accession Description Interval E-value
PRK13387 PRK13387
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional
1-318 2.00e-139

1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional


Pssm-ID: 237373  Cd Length: 317  Bit Score: 396.85  E-value: 2.00e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   1 MSLKSFLELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKDE-NYKKQENII 79
Cdd:PRK13387   1 MSAKLFLKLVEIHTKIASFFPVILGTLFSLYVAKIFDWLLFLAFMVAMLAFDIATTAINNYMDFKKALDTaDYVGIGNGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  80 GQANLSTNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVI 159
Cdd:PRK13387  81 GQHGLKPRNVLTVILLMYVVAAILGVYLCMNTSWLLLVIGLICFAIGILYTGGPLPLSRMPLGEIFSGLTMGFGIFLLAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 160 LINTSQDPIFSLNFdfTNNTFSLNGSIFAAIAMIIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLF 239
Cdd:PRK13387 161 YINTNTITIESLLF--QGEMFTIQGNLIAIIAIGVISLPIIFTIANIMLANNLRDLDEDIKNHRYTLVYYIGREKGVVLF 238
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500160075 240 QILMYASYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHEHQVPSPRSFVYSLRNMVLFNSAYAFSLLLSIIWQYLT 318
Cdd:PRK13387 239 AILFYASYLAIAVIVLMGYISPWALLSFLTLRKPISNLQSFQKEAKDPKYFVIAIRNTVLTNTTFGFLLSASLLIQYLF 317
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
6-316 1.26e-56

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 184.96  E-value: 1.26e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   6 FLELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKD-ENYKKQENIIGQANL 84
Cdd:COG1575    2 WLEAARPRTLPAAVAPVLLGTALAYYETGSFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDtEERVGPSRVIVSGLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  85 STNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVILINTs 164
Cdd:COG1575   82 SPKQVLRAALLLLALALLLGLYLVLLSGWPLLLLGLLGILAAIFYTGGPFPLGYRGLGELFVFLFFGLVAVLGTYYVQT- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 165 qdpifslnfdftnNTFSLNGsifaaiamIIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMY 244
Cdd:COG1575  161 -------------GTLSWAA--------LLASLPVGLLSAAVLLANNLRDIETDRAAGKRTLAVRLGRKRARRLYAALLL 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500160075 245 ASYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHeHQVPSPRSFVYSLRNMVLFNSAYAFSLLLSIIWQY 316
Cdd:COG1575  220 LAYLLILLLVLLGLLPPWALLALLSLPLALKLVRRV-LRGAKPEALIPALKNTALLNLLFGLLLALGLLLGR 290
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
7-311 4.58e-55

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 180.79  E-value: 4.58e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   7 LELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKD-ENYKKQENIIGQANLS 85
Cdd:cd13962    1 LLAARPRTLPASLAPVLLGTALAYYLGGFFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDtEPRSGPSRVLVSGLLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  86 TNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVILINTSQ 165
Cdd:cd13962   81 PRQVLRAALVLLLLAALLGLYLVALGGWLLLLLGLLGILAGYFYTGGPFPLSYRGLGELFVFLFFGLLAVLGTYYVQTGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 166 DPIFSLnfdftnntfslngsifaaiamiIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYA 245
Cdd:cd13962  161 LSWEVL----------------------LAALPLGLLIAAILLANNIRDIEADRAAGKRTLAVRLGRKRARRLYAALLLL 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500160075 246 SYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHEHQVPSPRSFVySLRNMVLFNSAYAFSLLLS 311
Cdd:cd13962  219 AYLLLLLLVLLGLLPLWSLLALLSLPLAIKLLRRLLRKADKPLLLI-ALKLTALLTLLFGLLLALG 283
UbiA pfam01040
UbiA prenyltransferase family;
104-272 1.17e-08

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 54.93  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  104 GFSLAYFVGWLFFLLGGIVFFIGVFYTygpIPLSRMPL-GEIFSGGTMGFGIFAMVILINTSQDPIFSLnfdftnntfsl 182
Cdd:pfam01040  80 GLLLLLLLNPLTALLGLAALLLYVLYT---LRLKRRTLlGQLVGGLAFGLPPLLGWAAVTGSLSPLALL----------- 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  183 ngsifaaiamiiASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYASYLAIILGFLSRIFEWP 262
Cdd:pfam01040 146 ------------LALALFLWTWAIALANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLY 213
                         170
                  ....*....|
gi 500160075  263 TLLSLLTFPI 272
Cdd:pfam01040 214 LLLALLLAAL 223
menA TIGR00751
1,4-dihydroxy-2-naphthoate octaprenyltransferase; This membrane-associated enzyme converts 1, ...
206-275 2.62e-03

1,4-dihydroxy-2-naphthoate octaprenyltransferase; This membrane-associated enzyme converts 1,4-dihydroxy-2-naphthoic acid (DHNA) to demethylmenaquinone, a step in menaquinone biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 129834  Cd Length: 284  Bit Score: 39.09  E-value: 2.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  206 IMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYASYLAIILGFLSRIFEWPTLLSLLTFPIIRK 275
Cdd:TIGR00751 180 VLNINNLRDIPTDARAGKNTLAVRLGDARTRMYHQGLLAVAGVCTFVFMLATPISWWCVLFLLAAPLLLK 249
 
Name Accession Description Interval E-value
PRK13387 PRK13387
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional
1-318 2.00e-139

1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional


Pssm-ID: 237373  Cd Length: 317  Bit Score: 396.85  E-value: 2.00e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   1 MSLKSFLELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKDE-NYKKQENII 79
Cdd:PRK13387   1 MSAKLFLKLVEIHTKIASFFPVILGTLFSLYVAKIFDWLLFLAFMVAMLAFDIATTAINNYMDFKKALDTaDYVGIGNGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  80 GQANLSTNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVI 159
Cdd:PRK13387  81 GQHGLKPRNVLTVILLMYVVAAILGVYLCMNTSWLLLVIGLICFAIGILYTGGPLPLSRMPLGEIFSGLTMGFGIFLLAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 160 LINTSQDPIFSLNFdfTNNTFSLNGSIFAAIAMIIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLF 239
Cdd:PRK13387 161 YINTNTITIESLLF--QGEMFTIQGNLIAIIAIGVISLPIIFTIANIMLANNLRDLDEDIKNHRYTLVYYIGREKGVVLF 238
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500160075 240 QILMYASYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHEHQVPSPRSFVYSLRNMVLFNSAYAFSLLLSIIWQYLT 318
Cdd:PRK13387 239 AILFYASYLAIAVIVLMGYISPWALLSFLTLRKPISNLQSFQKEAKDPKYFVIAIRNTVLTNTTFGFLLSASLLIQYLF 317
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
6-316 1.26e-56

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 184.96  E-value: 1.26e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   6 FLELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKD-ENYKKQENIIGQANL 84
Cdd:COG1575    2 WLEAARPRTLPAAVAPVLLGTALAYYETGSFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDtEERVGPSRVIVSGLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  85 STNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVILINTs 164
Cdd:COG1575   82 SPKQVLRAALLLLALALLLGLYLVLLSGWPLLLLGLLGILAAIFYTGGPFPLGYRGLGELFVFLFFGLVAVLGTYYVQT- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 165 qdpifslnfdftnNTFSLNGsifaaiamIIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMY 244
Cdd:COG1575  161 -------------GTLSWAA--------LLASLPVGLLSAAVLLANNLRDIETDRAAGKRTLAVRLGRKRARRLYAALLL 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500160075 245 ASYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHeHQVPSPRSFVYSLRNMVLFNSAYAFSLLLSIIWQY 316
Cdd:COG1575  220 LAYLLILLLVLLGLLPPWALLALLSLPLALKLVRRV-LRGAKPEALIPALKNTALLNLLFGLLLALGLLLGR 290
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
7-311 4.58e-55

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 180.79  E-value: 4.58e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   7 LELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFLVAMLLFDMTVTAINNYQDYKKAKD-ENYKKQENIIGQANLS 85
Cdd:cd13962    1 LLAARPRTLPASLAPVLLGTALAYYLGGFFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDtEPRSGPSRVLVSGLLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  86 TNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVILINTSQ 165
Cdd:cd13962   81 PRQVLRAALVLLLLAALLGLYLVALGGWLLLLLGLLGILAGYFYTGGPFPLSYRGLGELFVFLFFGLLAVLGTYYVQTGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 166 DPIFSLnfdftnntfslngsifaaiamiIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYA 245
Cdd:cd13962  161 LSWEVL----------------------LAALPLGLLIAAILLANNIRDIEADRAAGKRTLAVRLGRKRARRLYAALLLL 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500160075 246 SYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHEHQVPSPRSFVySLRNMVLFNSAYAFSLLLS 311
Cdd:cd13962  219 AYLLLLLLVLLGLLPLWSLLALLSLPLAIKLLRRLLRKADKPLLLI-ALKLTALLTLLFGLLLALG 283
PRK06080 PRK06080
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated
1-316 6.91e-55

1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated


Pssm-ID: 235695  Cd Length: 293  Bit Score: 180.34  E-value: 6.91e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075   1 MSLKSFLELVEIKTKIASIFPYLIGILFSISYFKILNLGLSLLFlVAMLLFDMTVTAINNYQDYKKAKD-ENYKKQENII 79
Cdd:PRK06080   1 STFKAWLELARPKTLPAAFAPVLVGTALAYWLGSFHPLLALLAL-LAALLLQIATNLANDYGDYVKGTDtEDRVGPLRAI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  80 GQANLSTNLVAFIILLMLALSLILGFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLSRMPLGEIFSGGTMGFGIFAMVI 159
Cdd:PRK06080  80 GRGGISPKQVKRAAIAFFGLAALLGLYLVAVSGWWLLLLGLLCIAAAILYTGGPKPYGYTGLGELFVGVFFGLVIVLGTY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 160 LINTSQDPIFSLnfdftnntfslngsifaaiamiIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLF 239
Cdd:PRK06080 160 YLQAGTVDSAVF----------------------LPALPCGLLIGAVLLANNIRDIETDRENGKNTLAVRLGDKNARRLH 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500160075 240 QILMYASYLAIILGFLSRIFEWPTLLSLLTFPIIRKNLKAHEHQvPSPRSFVYSLRNMVLFNSAYAFSLLLSIIWQY 316
Cdd:PRK06080 218 AALLALAYLCIVLLALLGLASPWGLLFLLSLPLAVKAARPVLRK-QKPETLIPALKATGKTNLLFGLLFAIGLLLSQ 293
UbiA pfam01040
UbiA prenyltransferase family;
104-272 1.17e-08

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 54.93  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  104 GFSLAYFVGWLFFLLGGIVFFIGVFYTygpIPLSRMPL-GEIFSGGTMGFGIFAMVILINTSQDPIFSLnfdftnntfsl 182
Cdd:pfam01040  80 GLLLLLLLNPLTALLGLAALLLYVLYT---LRLKRRTLlGQLVGGLAFGLPPLLGWAAVTGSLSPLALL----------- 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  183 ngsifaaiamiiASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYASYLAIILGFLSRIFEWP 262
Cdd:pfam01040 146 ------------LALALFLWTWAIALANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLY 213
                         170
                  ....*....|
gi 500160075  263 TLLSLLTFPI 272
Cdd:pfam01040 214 LLLALLLAAL 223
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
104-271 1.79e-04

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 42.34  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 104 GFSLAYFVGWLFFLLGGIVFFIGVFYTYGPIPLsrMPLGEIFSGGTMGFGIFAMVILINTSQDPIFSLnfdftnntfsln 183
Cdd:cd13956   90 GLALALALGPLALLLLLAGLLLGLAYSLGLKRL--KLGGWGVLGYATGLALLPGLGAVAAGGLVPLAL------------ 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075 184 gsifaaiamiIASLPLIFTIANIMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYASYLAIILGFLSRIFEWPT 263
Cdd:cd13956  156 ----------LLALVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAAGLLLAALILVVLLAVAGLLGPLA 225

                 ....*...
gi 500160075 264 LLSLLTFP 271
Cdd:cd13956  226 LLALLAVA 233
menA TIGR00751
1,4-dihydroxy-2-naphthoate octaprenyltransferase; This membrane-associated enzyme converts 1, ...
206-275 2.62e-03

1,4-dihydroxy-2-naphthoate octaprenyltransferase; This membrane-associated enzyme converts 1,4-dihydroxy-2-naphthoic acid (DHNA) to demethylmenaquinone, a step in menaquinone biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 129834  Cd Length: 284  Bit Score: 39.09  E-value: 2.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160075  206 IMLANNLRDLDTDIKNHRYTLVYYIGRPYGIKLFQILMYASYLAIILGFLSRIFEWPTLLSLLTFPIIRK 275
Cdd:TIGR00751 180 VLNINNLRDIPTDARAGKNTLAVRLGDARTRMYHQGLLAVAGVCTFVFMLATPISWWCVLFLLAAPLLLK 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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