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Conserved domains on  [gi|501220306|ref|WP_012263324|]
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DeoR/GlpR family DNA-binding transcription regulator [Actinobacillus pleuropneumoniae]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-251 8.08e-86

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 255.83  E-value: 8.08e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   5 NTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEMIDDS-NEKL---SKQKLA 80
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPfAEREtlnAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  81 IANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATELTLLDNePTVLMTGGTWDSRSDSFQGKVAEQV 159
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPN-IEVILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 160 LCSYDFDQLFIGADSLDLERGTTTFNEL-VGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITEEVK 238
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEeAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 501220306 239 AAIEKHGVQVIIA 251
Cdd:COG1349  241 EALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-251 8.08e-86

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 255.83  E-value: 8.08e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   5 NTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEMIDDS-NEKL---SKQKLA 80
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPfAEREtlnAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  81 IANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATELTLLDNePTVLMTGGTWDSRSDSFQGKVAEQV 159
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPN-IEVILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 160 LCSYDFDQLFIGADSLDLERGTTTFNEL-VGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITEEVK 238
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEeAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 501220306 239 AAIEKHGVQVIIA 251
Cdd:COG1349  241 EALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
7-251 6.84e-81

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 243.44  E-value: 6.84e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   7 QQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEM---IDDSNEKLSKQKLAIAN 83
Cdd:PRK10434   4 RQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESdppIDHKTLINTHKKELIAE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  84 EAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATELTLLDNEPTVLMTGGTWDSRSDSFQGKVAEQVLCS 162
Cdd:PRK10434  84 AAVSLIHDGDSIILDAGSTVLQMVPLLSRfNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEH 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 163 YDFDQLFIGADSLDLERGTTTFNELVGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITEEVKAAIE 242
Cdd:PRK10434 164 FTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQALE 243


                 ....*....
gi 501220306 243 KHGVQVIIA 251
Cdd:PRK10434 244 EKGIEVIIT 252
AgaR NF040755
transcriptional repressor AgaR;
5-251 2.22e-62

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 195.95  E-value: 2.22e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   5 NTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGA------VKIPSEMIDDSNEKLSKQK 78
Cdd:NF040755   3 GTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAlindgfIPGAEPSVEDKSRLNTAVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  79 LAIANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATEltLLDNEPT-VLMTGGTWDSRSDSFQGKVA 156
Cdd:NF040755  83 RLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQhQDVVVMTNGLNVANE--LLEAEGVeVLMTGGHLRRQSLSFYGDQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 157 EQVLCSYDFDQLFIGADSLDLERGTTTFNE-LVGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITE 235
Cdd:NF040755 161 EQSLQNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPE 240

                        250
                 ....*....|....*.
gi 501220306 236 EVKAAIEKHGVQVIIA 251
Cdd:NF040755 241 EYLQGLRKLGVEVILV 256
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 77-231 4.86e-47

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 153.44  E-value: 4.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   77 QKLAIANEAVKQIRDHNRIIIDSGSTTGAMVKML-YQTGLVVMTNSLSLATELTLLDNePTVLMTGGTWDSRSDSFQGKV 155
Cdd:pfam00455   5 EKRRIAKAAASLIEDGDTIFLDAGTTTLELARALpDRRNLTVITNSLNIANELSEKPD-IEVILLGGEVRPKTGAFVGPL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501220306  156 AEQVLCSYDFDQLFIGADSLDLERGTTTFNEL-VGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDS 231
Cdd:pfam00455  84 AEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEeAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 5.00e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 56.46  E-value: 5.00e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 501220306     9 RRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAV 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-251 8.08e-86

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 255.83  E-value: 8.08e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   5 NTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEMIDDS-NEKL---SKQKLA 80
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPfAEREtlnAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  81 IANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATELTLLDNePTVLMTGGTWDSRSDSFQGKVAEQV 159
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPN-IEVILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 160 LCSYDFDQLFIGADSLDLERGTTTFNEL-VGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITEEVK 238
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEeAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 501220306 239 AAIEKHGVQVIIA 251
Cdd:COG1349  241 EALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
7-251 6.84e-81

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 243.44  E-value: 6.84e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   7 QQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEM---IDDSNEKLSKQKLAIAN 83
Cdd:PRK10434   4 RQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESdppIDHKTLINTHKKELIAE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  84 EAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATELTLLDNEPTVLMTGGTWDSRSDSFQGKVAEQVLCS 162
Cdd:PRK10434  84 AAVSLIHDGDSIILDAGSTVLQMVPLLSRfNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEH 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 163 YDFDQLFIGADSLDLERGTTTFNELVGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITEEVKAAIE 242
Cdd:PRK10434 164 FTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQALE 243


                 ....*....
gi 501220306 243 KHGVQVIIA 251
Cdd:PRK10434 244 EKGIEVIIT 252
AgaR NF040755
transcriptional repressor AgaR;
5-251 2.22e-62

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 195.95  E-value: 2.22e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   5 NTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGA------VKIPSEMIDDSNEKLSKQK 78
Cdd:NF040755   3 GTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAlindgfIPGAEPSVEDKSRLNTAVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  79 LAIANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATEltLLDNEPT-VLMTGGTWDSRSDSFQGKVA 156
Cdd:NF040755  83 RLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQhQDVVVMTNGLNVANE--LLEAEGVeVLMTGGHLRRQSLSFYGDQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 157 EQVLCSYDFDQLFIGADSLDLERGTTTFNE-LVGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITE 235
Cdd:NF040755 161 EQSLQNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPE 240

                        250
                 ....*....|....*.
gi 501220306 236 EVKAAIEKHGVQVIIA 251
Cdd:NF040755 241 EYLQGLRKLGVEVILV 256
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-252 1.21e-50

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 166.57  E-value: 1.21e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   4 RNTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEM------IDDSNEKLSKQ 77
Cdd:PRK09802  13 TGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSTTpsvepsVEDKSALNTAM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  78 KLAIANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQ-TGLVVMTNSLSLATELtlLDNEP-TVLMTGGTWDSRSDSFQGKV 155
Cdd:PRK09802  93 KRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKhTDVIAMTNGMNVANAL--LEAEGvELLMTGGHLRRQSQSFYGDQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 156 AEQVLCSYDFDQLFIGADSLDLERGTTTFNELVG-LSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEIT 234
Cdd:PRK09802 171 AEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEArLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIP 250

                        250
                 ....*....|....*...
gi 501220306 235 EEVKAAIEKHGVQVIIAQ 252
Cdd:PRK09802 251 ADSLEGLRKAGVEVILVG 268
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 77-231 4.86e-47

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 153.44  E-value: 4.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   77 QKLAIANEAVKQIRDHNRIIIDSGSTTGAMVKML-YQTGLVVMTNSLSLATELTLLDNePTVLMTGGTWDSRSDSFQGKV 155
Cdd:pfam00455   5 EKRRIAKAAASLIEDGDTIFLDAGTTTLELARALpDRRNLTVITNSLNIANELSEKPD-IEVILLGGEVRPKTGAFVGPL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501220306  156 AEQVLCSYDFDQLFIGADSLDLERGTTTFNEL-VGLSQVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDS 231
Cdd:pfam00455  84 AEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEeAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
8-248 3.17e-18

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 81.06  E-value: 3.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   8 QRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVkIPSEMID----DSNEKLSKQKLAIAN 83
Cdd:PRK10906   5 QRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAA-LPSSSVNtpwhDRKATQTEEKERIAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  84 EAVKQIRDHNRIIIDSGSTTGAMV-KMLYQTGLVVMTNSLSLATelTLLDNEP-TVLMTGGTWDSRSDSFQGKVAEQVLC 161
Cdd:PRK10906  84 KVASQIPNGATLFIDIGTTPEAVAhALLNHSNLRIVTNNLNVAN--TLMAKEDfRIILAGGELRSRDGGIIGEATLDFIS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 162 SYDFDQLFIGADSLDLERGTTTFN-ELVGLSQVMAKVSREVIVLIESQKFGRK-MPNLElEWAAIHKLITDSEITEEVKA 239
Cdd:PRK10906 162 QFRLDFGILGISGIDSDGSLLEFDyHEVRTKRAIIENSRHVMLVVDHSKFGRNaMVNMG-SISMVDAVYTDQLPPASVMQ 240


                 ....*....
gi 501220306 240 AIEKHGVQV 248
Cdd:PRK10906 241 VIEDHHVQL 249
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
5-251 1.15e-15

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 73.89  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   5 NTQQRRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEM-----IDDSNEKLSKQKL 79
Cdd:PRK13509   2 TEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRprwtpMNIHQAQNHDEKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  80 AIANEAVKQIRDHNRIIIDSGSTTGAMVKMLYQTGLVVMTNSLSLATELTLLDNEPTVLMtGGTWDsRSDSFQGKVAEQV 159
Cdd:PRK13509  82 RIAKAASQLCNPGESVVINCGSTAFLLGRELCGKPVQIITNYLPLANYLIDQEHDSVIIM-GGQYN-KSQSITLSPQGSE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 160 LCSYDFDQLFIGADSLDLErGTTTFNELVGLS-QVMAKVSREVIVLIESQKFGRKMPNLELEWAAIHKLITDSEITEEVK 238
Cdd:PRK13509 160 NSLYAGHWMFTSGKGLTAD-GLYKTDMLTAMAeQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADPEVL 238

                        250
                 ....*....|...
gi 501220306 239 AAIEKHGVQVIIA 251
Cdd:PRK13509 239 QQLEAQGVSILLV 251
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 5.00e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 56.46  E-value: 5.00e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 501220306     9 RRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAV 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
PRK10411 PRK10411
L-fucose operon activator;
9-212 1.72e-09

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 56.35  E-value: 1.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306   9 RRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSEMIDDSNEKLSK------QKLAIA 82
Cdd:PRK10411   5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRlkshyaHKADIA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  83 NEAVKQIRDHNRIIIDSGSTTGAMVKMLYQTGLVVMTNSLSLATELTLLDnEPTVLMTGGTWDSRSDSFQGKVAEQVLCS 162
Cdd:PRK10411  85 REALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRE-RIQLISSGGTLERKYGCYVNPSLISQLKS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 501220306 163 YDFDqLFI----GADSLDLERGTTTFNelVGLSQVMAKVSREVIVLIESQKFGR 212
Cdd:PRK10411 164 LEID-LFIfsceGIDSSGALWDSNAIN--ADYKSMLLKRAAQSLLLIDKSKFNR 214
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 35-249 3.86e-09

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 55.47  E-value: 3.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306  35 SEVTIRKDLTALEESGFLLrryGGAV-----KIPSEMIDDSNEKLSKQKLAIANEAVKQIRDHNRIIIDSGSTTGAMVKM 109
Cdd:PRK10681  34 SEMTIRRDLNAHSAPVVLL---GGYIvleprSASHYLLSDQKSRLVEEKRRAAQLAATLVEPNQTLFFDCGTTTPWIIEA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501220306 110 LyQTGLVVMTNSLSLATELTLLDN-EPTVLMTGGTWDSRSDSFQGKVAEQVLCSYDFDQLFIGADSLDLERGTTTFN--E 186
Cdd:PRK10681 111 I-DNELPFTAVCYSLNTFLALQEKpHCRAILCGGEFHASNAIFKPLDFQQTLDNICPDIAFYSAAGVHVSKGATCFNleE 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501220306 187 LVGLSQVMAKVSREVIVlIESQKFGRKMPNLELEWAAIHKLITDSEITEEVKAAIEKHGVQVI 249
Cdd:PRK10681 190 LPVKHWAMAMAQKHVLV-VDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRIKLM 251
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
9-65 4.19e-09

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 51.49  E-value: 4.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 501220306    9 RRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRYGGAVKIPSE 65
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSST 57
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
9-56 6.43e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.82  E-value: 6.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 501220306   9 RRHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGFLLRRY 56
Cdd:COG2345   14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 10-51 8.76e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 33.56  E-value: 8.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 501220306   10 RHLIVKMVQEESEVSVDTLAHFFETSEVTIRKDLTALEESGF 51
Cdd:pfam08279   1 LQILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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