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Conserved domains on  [gi|503064793|ref|WP_013299769|]
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MULTISPECIES: TrbC/VirB2 family protein [Alphaproteobacteria]

Protein Classification

TrbC/VirB2 family protein( domain architecture ID 10008057)

TrbC/VirB2 family protein may function a major pilus subunit; similar to type IV secretion system protein PtlA, which is a component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VirB2 COG3838
Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and ...
 10-90 2.44e-25

Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 443049  Cd Length: 109  Bit Score: 91.17  E-value: 2.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503064793  10 ALAITFGLIVLVGPAHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFGDTGGGFRKLIQIVFGLSIAFTA 89
Cdd:COG3838   14 LLALAALLLLLASPAFAAGSGMPWEGPLQQIVNSLTGPVAKAIAVIAIIVAGLMLAFGELNGGFRRAIQVVLGISIAFGA 93


                 .
gi 503064793  90 T 90
Cdd:COG3838   94 S 94
 
Name Accession Description Interval E-value
VirB2 COG3838
Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and ...
 10-90 2.44e-25

Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443049  Cd Length: 109  Bit Score: 91.17  E-value: 2.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503064793  10 ALAITFGLIVLVGPAHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFGDTGGGFRKLIQIVFGLSIAFTA 89
Cdd:COG3838   14 LLALAALLLLLASPAFAAGSGMPWEGPLQQIVNSLTGPVAKAIAVIAIIVAGLMLAFGELNGGFRRAIQVVLGISIAFGA 93


                 .
gi 503064793  90 T 90
Cdd:COG3838   94 S 94
TrbC pfam04956
TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein ...
 9-90 5.39e-14

TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains VIRB2 type IV secretion proteins. This alignment contains two predicted transmembrane helices.


Pssm-ID: 398559  Cd Length: 98  Bit Score: 61.85  E-value: 5.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503064793    9 RALAITFGLIVLVGPAHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFGDTggGFRKLIQIVFGLSIAFT 88
Cdd:pfam04956  13 LALALAALLLLLASPAFAQGSGDPVETALQNIVDSLTGPIARVIATIAIIIAGIMLAFGRL--SWRTLVYVVIGIVIIFG 90


                  ..
gi 503064793   89 AT 90
Cdd:pfam04956  91 AS 92
PRK13871 PRK13871
conjugal transfer protein TrbC; Provisional
 24-67 1.15e-05

conjugal transfer protein TrbC; Provisional


Pssm-ID: 172391  Cd Length: 135  Bit Score: 41.41  E-value: 1.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 503064793  24 AHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFG 67
Cdd:PRK13871  28 ASSGGGSLPWESPLQQIQQSITGPVAGFIALAAVAIAGAMLIFG 71
 
Name Accession Description Interval E-value
VirB2 COG3838
Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and ...
 10-90 2.44e-25

Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443049  Cd Length: 109  Bit Score: 91.17  E-value: 2.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503064793  10 ALAITFGLIVLVGPAHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFGDTGGGFRKLIQIVFGLSIAFTA 89
Cdd:COG3838   14 LLALAALLLLLASPAFAAGSGMPWEGPLQQIVNSLTGPVAKAIAVIAIIVAGLMLAFGELNGGFRRAIQVVLGISIAFGA 93


                 .
gi 503064793  90 T 90
Cdd:COG3838   94 S 94
TrbC pfam04956
TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein ...
 9-90 5.39e-14

TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains VIRB2 type IV secretion proteins. This alignment contains two predicted transmembrane helices.


Pssm-ID: 398559  Cd Length: 98  Bit Score: 61.85  E-value: 5.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503064793    9 RALAITFGLIVLVGPAHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFGDTggGFRKLIQIVFGLSIAFT 88
Cdd:pfam04956  13 LALALAALLLLLASPAFAQGSGDPVETALQNIVDSLTGPIARVIATIAIIIAGIMLAFGRL--SWRTLVYVVIGIVIIFG 90


                  ..
gi 503064793   89 AT 90
Cdd:pfam04956  91 AS 92
PRK13871 PRK13871
conjugal transfer protein TrbC; Provisional
 24-67 1.15e-05

conjugal transfer protein TrbC; Provisional


Pssm-ID: 172391  Cd Length: 135  Bit Score: 41.41  E-value: 1.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 503064793  24 AHAAGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAFG 67
Cdd:PRK13871  28 ASSGGGSLPWESPLQQIQQSITGPVAGFIALAAVAIAGAMLIFG 71
PRK13892 PRK13892
conjugal transfer protein TrbC; Provisional
 20-80 3.71e-03

conjugal transfer protein TrbC; Provisional


Pssm-ID: 184376  Cd Length: 134  Bit Score: 34.34  E-value: 3.71e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503064793  20 LVGPAHA-----AGSGMPWEAPLDSILQSIEGPVAKIVGTLAIIITGLTLAF-GDTGGGFRKLIQIV 80
Cdd:PRK13892  28 LLAPQHAfasegTGGSLPYESWLTNLRNSVTGPVAFALSIIGIVVAGGILIFgGELNGFFRTLIFIV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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