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MULTISPECIES: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Bacillus]

Protein Classification

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase( domain architecture ID 10087567)

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin to form AMP and 6-hydroxymethyl-7,8-dihydropterin diphosphate

CATH:  3.30.70.560
EC:  2.7.6.3
Gene Ontology:  GO:0005524|GO:0003848|GO:0009396
SCOP:  4001325

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HPPK cd00483
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential ...
 5-132 7.21e-77

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.


:

Pssm-ID: 238269  Cd Length: 128  Bit Score: 225.05  E-value: 7.21e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   5 AYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGR 84
Cdd:cd00483    1 VYLALGSNLGDRLANLRAALRALAALPGIEILAVSPLYETAPVGFTDQPDFLNAVVELETSLSPLELLDALQAIEQRLGR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 504291512  85 TREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEI 132
Cdd:cd00483   81 VRKERWGPRTLDLDILLYGDEVIDTPDLTLPHPRMHERAFVLVPLAEI 128
 
Name Accession Description Interval E-value
HPPK cd00483
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential ...
 5-132 7.21e-77

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.


Pssm-ID: 238269  Cd Length: 128  Bit Score: 225.05  E-value: 7.21e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   5 AYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGR 84
Cdd:cd00483    1 VYLALGSNLGDRLANLRAALRALAALPGIEILAVSPLYETAPVGFTDQPDFLNAVVELETSLSPLELLDALQAIEQRLGR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 504291512  85 TREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEI 132
Cdd:cd00483   81 VRKERWGPRTLDLDILLYGDEVIDTPDLTLPHPRMHERAFVLVPLAEI 128
FolK COG0801
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport ...
 4-133 7.70e-77

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport and metabolism]; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440564  Cd Length: 155  Bit Score: 225.74  E-value: 7.70e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   4 IAYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELG 83
Cdd:COG0801    1 RVYLALGSNLGDREANLRAALEALAALPGIRVLAVSSVYETPPVGFTDQPDFLNAVVLLETDLSPEELLDALQAIEAELG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 504291512  84 RTREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEIC 133
Cdd:COG0801   81 RVRKERWGPRTLDLDILLYGDLVIDTPRLTLPHPRMHERAFVLVPLAEIA 130
HPPK pfam01288
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);
6-133 7.64e-75

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);


Pssm-ID: 460149  Cd Length: 128  Bit Score: 219.56  E-value: 7.64e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512    6 YIALGSNIGDRETYLRQAVASLHQHAaVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRT 85
Cdd:pfam01288   1 YLALGSNLGDREANLRAALAALAALG-GKVVAVSSLYETAPVGGTDQPDFLNAVVEIETDLSPEELLDALQAIERELGRV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 504291512   86 REVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEIC 133
Cdd:pfam01288  80 REIRWGPRTIDLDILLYGDEVIDTPRLTLPHPRMHERAFVLVPLAEIA 127
folK TIGR01498
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the ...
 5-134 4.68e-68

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the folate biosynthesis enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Alternate names include 6-hydroxymethyl-7,8-dihydropterin diphosphokinase and 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK). The extreme C-terminal region, of typically eight to thirty residues, is not included in the model. This enzyme may be found as a fusion protein with other enzymes of folate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273658  Cd Length: 129  Bit Score: 202.50  E-value: 4.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512    5 AYIALGSNIGDRETYLRQAVASLHQHAaVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGR 84
Cdd:TIGR01498   1 AYIALGSNLGDRLKNLRAALAALAALP-VRLLIVSSIYETPPWGFTDQPDFLNAVVEVETTLSPRELLALLQAIEAEFGR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 504291512   85 TREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEICQ 134
Cdd:TIGR01498  80 VREFRWGPRTLDLDILLYGDEVLDTPDLTVPHPRALERPFVLLPLAEIAP 129
PRK10239 PRK10239
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;
4-132 3.57e-37

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;


Pssm-ID: 182325  Cd Length: 159  Bit Score: 125.29  E-value: 3.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   4 IAYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELG 83
Cdd:PRK10239   3 VAYIAIGSNLASPLEQVNAALKALGDIPESRILAVSSFYRTPPLGPQDQPDYLNAAVALETALAPEELLNHTQRIELQQG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 504291512  84 RTREV-RWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEI 132
Cdd:PRK10239  83 RVRKAeRWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEI 132
 
Name Accession Description Interval E-value
HPPK cd00483
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential ...
 5-132 7.21e-77

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.


Pssm-ID: 238269  Cd Length: 128  Bit Score: 225.05  E-value: 7.21e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   5 AYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGR 84
Cdd:cd00483    1 VYLALGSNLGDRLANLRAALRALAALPGIEILAVSPLYETAPVGFTDQPDFLNAVVELETSLSPLELLDALQAIEQRLGR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 504291512  85 TREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEI 132
Cdd:cd00483   81 VRKERWGPRTLDLDILLYGDEVIDTPDLTLPHPRMHERAFVLVPLAEI 128
FolK COG0801
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport ...
 4-133 7.70e-77

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport and metabolism]; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440564  Cd Length: 155  Bit Score: 225.74  E-value: 7.70e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   4 IAYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELG 83
Cdd:COG0801    1 RVYLALGSNLGDREANLRAALEALAALPGIRVLAVSSVYETPPVGFTDQPDFLNAVVLLETDLSPEELLDALQAIEAELG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 504291512  84 RTREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEIC 133
Cdd:COG0801   81 RVRKERWGPRTLDLDILLYGDLVIDTPRLTLPHPRMHERAFVLVPLAEIA 130
HPPK pfam01288
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);
6-133 7.64e-75

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);


Pssm-ID: 460149  Cd Length: 128  Bit Score: 219.56  E-value: 7.64e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512    6 YIALGSNIGDRETYLRQAVASLHQHAaVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRT 85
Cdd:pfam01288   1 YLALGSNLGDREANLRAALAALAALG-GKVVAVSSLYETAPVGGTDQPDFLNAVVEIETDLSPEELLDALQAIERELGRV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 504291512   86 REVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEIC 133
Cdd:pfam01288  80 REIRWGPRTIDLDILLYGDEVIDTPRLTLPHPRMHERAFVLVPLAEIA 127
folK TIGR01498
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the ...
 5-134 4.68e-68

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the folate biosynthesis enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Alternate names include 6-hydroxymethyl-7,8-dihydropterin diphosphokinase and 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK). The extreme C-terminal region, of typically eight to thirty residues, is not included in the model. This enzyme may be found as a fusion protein with other enzymes of folate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273658  Cd Length: 129  Bit Score: 202.50  E-value: 4.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512    5 AYIALGSNIGDRETYLRQAVASLHQHAaVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGR 84
Cdd:TIGR01498   1 AYIALGSNLGDRLKNLRAALAALAALP-VRLLIVSSIYETPPWGFTDQPDFLNAVVEVETTLSPRELLALLQAIEAEFGR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 504291512   85 TREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEICQ 134
Cdd:TIGR01498  80 VREFRWGPRTLDLDILLYGDEVLDTPDLTVPHPRALERPFVLLPLAEIAP 129
PRK10239 PRK10239
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;
4-132 3.57e-37

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;


Pssm-ID: 182325  Cd Length: 159  Bit Score: 125.29  E-value: 3.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   4 IAYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELG 83
Cdd:PRK10239   3 VAYIAIGSNLASPLEQVNAALKALGDIPESRILAVSSFYRTPPLGPQDQPDYLNAAVALETALAPEELLNHTQRIELQQG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 504291512  84 RTREV-RWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEI 132
Cdd:PRK10239  83 RVRKAeRWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEI 132
PRK14092 PRK14092
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;
1-132 1.16e-34

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;


Pssm-ID: 172582  Cd Length: 163  Bit Score: 119.30  E-value: 1.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504291512   1 MNNIAYIALGSNIGDRETYLRQAVASLHQHAAVTVTKVSSIYETDPVgyedQAQ---FLNMAVEIKTSLNPFELLELTQQ 77
Cdd:PRK14092   6 ASALAYVGLGANLGDAAATLRSVLAELAAAPGILACKASRLYRTAPV----DAQgpdFVNAVAALDTTLAPLDLLDLLQA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504291512  78 IENELGRTREVRWGPRTADLDILLFNRENIESEQLIVPHPRMYERLFVLAPLAEI 132
Cdd:PRK14092  82 LEQRHGRERPYRNAPRTLDLDLLLYGEQAIDHPRLSVPHPRMHERAFVLAPLCEL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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