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Conserved domains on  [gi|504450152|ref|WP_014637254|]
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MULTISPECIES: phosphopantetheine-binding protein [Streptococcus]

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 1-79 3.75e-18

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PRK12449:

Pssm-ID: 447865 [Multi-domain]  Cd Length: 80  Bit Score: 71.27  E-value: 3.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504450152  1 MTREQVYQRVVELIQDEKG-EDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:PRK12449  1 MTREEIFERLINLIQKQRSyLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQRLT 80
 
Name Accession Description Interval E-value
PRK12449 PRK12449
acyl carrier protein; Provisional
 1-79 3.75e-18

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 71.27  E-value: 3.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504450152  1 MTREQVYQRVVELIQDEKG-EDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:PRK12449  1 MTREEIFERLINLIQKQRSyLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQRLT 80
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-79 8.10e-10

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 49.85  E-value: 8.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504450152  1 MTREQVYQRVVELIQDEKGEDF-QVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:COG0236   1 MPREELEERLAEIIAEVLGVDPeEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 6-76 3.37e-05

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 38.15  E-value: 3.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504450152   6 VYQRVVELIQDEKGED-FQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYE 76
Cdd:TIGR00517  4 IFEKVKAIIKEQLNVDeDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEE 75
 
Name Accession Description Interval E-value
PRK12449 PRK12449
acyl carrier protein; Provisional
 1-79 3.75e-18

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 71.27  E-value: 3.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504450152  1 MTREQVYQRVVELIQDEKG-EDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:PRK12449  1 MTREEIFERLINLIQKQRSyLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQRLT 80
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 4-74 7.58e-10

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 51.62  E-value: 7.58e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504450152   4 EQVYQRVVELI-QDEKGEDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFI 74
Cdd:PTZ00171  69 EDVLTRVKKVVkNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYI 140
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-79 8.10e-10

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 49.85  E-value: 8.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504450152  1 MTREQVYQRVVELIQDEKGEDF-QVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:COG0236   1 MPREELEERLAEIIAEVLGVDPeEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
acpP PRK00982
acyl carrier protein; Provisional
 3-79 7.36e-09

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 47.47  E-value: 7.36e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504450152  3 REQVYQRVVELIQDEKG-EDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGvDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acpP CHL00124
acyl carrier protein; Validated
 1-80 9.80e-09

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 47.32  E-value: 9.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504450152  1 MTREQVYQRVVELIQDEKG-EDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYEEVK 79
Cdd:CHL00124  1 MTKNDIFEKVQSIVAEQLGiEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKIN 80


                .
gi 504450152 80 K 80
Cdd:CHL00124 81 K 81
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 6-76 3.37e-05

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 38.15  E-value: 3.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504450152   6 VYQRVVELIQDEKGED-FQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYE 76
Cdd:TIGR00517  4 IFEKVKAIIKEQLNVDeDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEE 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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