|
Name |
Accession |
Description |
Interval |
E-value |
| malate_HK_MalK |
NF038334 |
malate sensor histidine kinase MalK; |
1-533 |
0e+00 |
|
malate sensor histidine kinase MalK;
Pssm-ID: 439628 [Multi-domain] Cd Length: 533 Bit Score: 1003.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 1 MKKTLRLQTRLTIFVCIVVLISLCITFFTIWSETAKNIHQQERDIALSTAKMVAEAPITAKSLEKDQSYTALRKYTTSVQ 80
Cdd:NF038334 1 MKKTLKLQTRLTIFVCIVVLISLCITFFTIGSETAKNIREQERDIALQTAKMVAEAPITAKSLESGKSYKELRQYTTRVQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 81 RITKTEFVVVMDMNGIRKTHPNPQKIGKRFAGGDEKPALQGKEHISTASGTLGKSMRAFVPVYNQDGKQLGAVAVGITLK 160
Cdd:NF038334 81 KITGTEFVVVMDMNGIRKTHPDPNKIGKKFAGGDEEPALKGHEHISTASGTLGKSMRAFVPVYDKDGKQVGAVAVGITLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 161 EIDLIIHQSLLPLYFVTSLSLLSGIIGALIVARKVKKIMFGLEPDEIATLLKERSAMLESTKEGILAVDQHGKIKLANAE 240
Cdd:NF038334 161 EIDLIISQSLRPLYFVICLSIFVGIIGAVIVARKVKNIMFGLEPYEIATLLEERSAMLESTKEGILAVDQHGKIKLANAE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 241 AKRLFHNMGIMVDPREQDVQALLPSSGLKQVIETRKPLLDRDVRMNGLELVFNEVPITVKGEIVGAIATFRDKTEVKHLA 320
Cdd:NF038334 241 AKRLFHKMGIMTNPIDQDVQDILPKSRLKQVIETKKPLQDRDVRINGLELVFNEVPIHLKGQIVGAIATFRDKTEVKHLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 321 EQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETNEIINHVKNSVLAGFLLGKQSYIREQ 400
Cdd:NF038334 321 EQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETSEIINHVKNSVLAGFLLGKQSYIREQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 401 GAALEVNCSTQVPNSEDPAVTHDLITVIGNLLNNALDAVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQ 480
Cdd:NF038334 401 GATLEVICSTQIPNAADPAVIHDLITVIGNLLNNALDAVSQTEKKNISISFRFHDEQLDIEITDTGVGMSKEEQAKMFDQ 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 515937370 481 GFSTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKEDSHD 533
Cdd:NF038334 481 GFSTKGQNRGFGLYFVQQSIENLNGHMIVTSEKNEGTTFSLRIPYEPKEDNHD 533
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
1-532 |
0e+00 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 856.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 1 MKKTLRLQTRLTIFVCIVVLISLCITFFTIWSETAKNIHQQERDIALSTAKMVAEAPITAKSLEKDQSYTALRKYTTSVQ 80
Cdd:PRK11086 10 RKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGIQTYAEAVR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 81 RITKTEFVVVMDMNGIRKTHPNPQKIGKRFAGGDEKPALQGKEHISTASGTLGKSMRAFVPVYNQDGKQLGAVAVGITLK 160
Cdd:PRK11086 90 KRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGVVAVGISLS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 161 EIDLIIHQSLLPLYFVTSLSLLSGIIGALIVARKVKKIMFGLEPDEIATLLKERSAMLESTKEGILAVDQHGKIKLANAE 240
Cdd:PRK11086 170 EVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRGEVTLINDE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 241 AKRLF-HNMGIMVDPREQDVQALLPSSGLKQVIETRKPLLDRDVRMNGLELVFNEVPITVKGEIVGAIATFRDKTEVKHL 319
Cdd:PRK11086 250 AKRLFnYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFRDKTEVRQL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 320 AEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETNEIINHVKNSVLAGFLLGKQSYIRE 399
Cdd:PRK11086 330 AQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISRARE 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 400 QGAALEVNCSTQVPNSEDPAVTHDLITVIGNLLNNALDAVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFD 479
Cdd:PRK11086 410 LGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD 489
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 515937370 480 QGFSTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKEDSH 532
Cdd:PRK11086 490 KGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
153-528 |
1.40e-106 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 324.11 E-value: 1.40e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 153 VAVGITLKEIDLIIHQSLLPLYFVTSLSLLSGIIGALIVARKVKKIMFGLEP--DEIATLLKERSAMLESTKEGILAVDQ 230
Cdd:COG3290 23 LLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKllEEIARLVEEREAVLESIREGVIAVDR 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 231 HGKIKLANAEAKRLFHnmgimVDPREQDVQALLPssglkQVIETRKplLDRDVRMNGLELVFNEVPITVKGEIVGAIATF 310
Cdd:COG3290 103 DGRITLINDAARRLLG-----LDAIGRPIDEVLA-----EVLETGE--RDEEILLNGRVLVVNRVPIRDDGRVVGAVATF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 311 RDKTEVKHLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETNEIINHVKNSVLAGFL 390
Cdd:COG3290 171 RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 391 LGKQSYIREQGAALEVNCSTQVPNSEDPAvtHDLITVIGNLLNNALDAVSH--TENKNISISFRYVQEQLHIEITDTGVG 468
Cdd:COG3290 251 LGKAARARERGIDLTIDIDSDLPDLPLSD--TDLVTILGNLLDNAIEAVEKlpEEERRVELSIRDDGDELVIEVEDSGPG 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515937370 469 LTKEEQDIMFDQGFSTK-GEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQK 528
Cdd:COG3290 329 IPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
6-531 |
3.67e-66 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 223.56 E-value: 3.67e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 6 RLQTRLTIFVCIVVlISLCIT-----FFTIWSEtaKNIHQQERDIALSTAKMVA--EAPITAKsleKDQSYTALRKYTTS 78
Cdd:PRK15053 15 RLAFPLRIFLLILV-FSIFVIaalaqYFSASFE--DYLTLHVRDMAMNQAKIIAsnDSVISAV---KTRDYKRLATIANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 79 VQRITKTEFVVVMDMNGIRKTHPNPQKIGKRFAGGDEKPALQGKEHISTASGTLGKSMRAFVPVYNQDGKQLGAVAVGIT 158
Cdd:PRK15053 89 LQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 159 LKEIDLIIHQSLLPLYFVTSLSLLSGIIGALIVARKVKKIMFGLEPDEIATLLKERSAMLESTKEGILAVDQHGKIKLAN 238
Cdd:PRK15053 169 VSKIDSWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAIN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 239 AEAKRLfhnMGIMVDPRE---QDVQALLPSSG--LKQVIETRKpllDRDVRMNGLELVFNEVPITVKGEIVGAIATFRDK 313
Cdd:PRK15053 249 RNARKM---LGLSSPGRQwlgKPIAEVVRPADffTEQIDEKRQ---DVVANFNGLSVIANREAIRSGDDLLGAIISFRSK 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 314 TEVKHLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETNEIINHVKNSVLAGFLLGK 393
Cdd:PRK15053 323 DEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGK 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 394 QSYIREQGAALEVNCSTQVPNSEDPAVTHDLITVIGNLLNNALDAVSHTE--NKNISISFRYVQEQLHIEITDTGVGLTK 471
Cdd:PRK15053 403 VQRARELGLKMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDegNKIVELFLSDEGDDVVIEVADQGCGVPE 482
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515937370 472 EEQDIMFDQGFSTKGED---RGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKEDS 531
Cdd:PRK15053 483 SLRDKIFEQGVSTRADEpgeHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPNDS 545
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-524 |
1.78e-32 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 120.08 E-value: 1.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVSHT--ENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGE-DRGFGLYFVDQSI 500
Cdd:cd16915 1 LITIVGNLIDNALDALAATgaPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80
|
90 100
....*....|....*....|....
gi 515937370 501 KKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
133-530 |
9.15e-31 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 126.24 E-value: 9.15e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 133 GKSMRAFVPVYnQDGKQLGAVAVGITLKEIDLIIHQSLLPLYFVTSLSLLSGIIGALIVARK----VKKIMFGL------ 202
Cdd:PRK11360 153 GGILNSMIPIE-RNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRfsanVDIIKDGLstlend 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 203 ----------EPDEIA--------TLLKERS---AMLESTKEGILAVDQHGKIKLANAEAKRLF----HNMGimvdprEQ 257
Cdd:PRK11360 232 lstrlpplpgELGEISqainnlaqALRETRSlneLILESIADGVIAIDRQGKITTMNPAAEVITglqrHELV------GK 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 258 DVQALLPSSG-----LKQVIETRKPLLDRDVRM----NGLELVFNEVPI-TVKGEIVGAIATFRDKTEVKHLAEQLsgvk 327
Cdd:PRK11360 306 PYSELFPPNTpfaspLLDTLEHGTEHVDLEISFpgrdRTIELSVSTSLLhNTHGEMIGALVIFSDLTERKRLQRRV---- 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 328 MYANALRAQ-------SHEFMNKLHVILGLVQL--KNYDD------LGTYIKDI------------------AIYQQTET 374
Cdd:PRK11360 382 ARQERLAALgelvagvAHEIRNPLTAIRGYVQIwrQQTSDppsqeyLSVVLREVdrlnkvidqllefsrpreSQWQPVSL 461
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 375 NEIINHVknsvlAGFLL--GKQSYIReqgaaLEVNCSTQVPNSE-DPavtHDLITVIGNLLNNALDAVShtENKNISISF 451
Cdd:PRK11360 462 NALVEEV-----LQLFQtaGVQARVD-----FETELDNELPPIWaDP---ELLKQVLLNILINAVQAIS--ARGKIRIRT 526
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 452 RYVQE-QLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKED 530
Cdd:PRK11360 527 WQYSDgQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
215-532 |
7.48e-30 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 120.34 E-value: 7.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 215 SAMLESTKEGILAVDQHGKIKLANAEAKRLFhnmgiMVDPRE---QDVQALLPSSG-----LKQVIETRKPLLDRDV--- 283
Cdd:COG3852 10 RAILDSLPDAVIVLDADGRITYVNPAAERLL-----GLSAEEllgRPLAELFPEDSplrelLERALAEGQPVTEREVtlr 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 284 RMNGLELVFnEV---PITVKGEIVGAIATFRDKTEVKHLAEQLsgvkmyANALRAQS---------HEFMNKLHVILGLV 351
Cdd:COG3852 85 RKDGEERPV-DVsvsPLRDAEGEGGVLLVLRDITERKRLEREL------RRAEKLAAvgelaaglaHEIRNPLTGIRGAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 352 QL----KNYDDLGTYIKDI----------------------AIYQQTETNEIINHVKNSVLAGFLLGKQsyIREQgaale 405
Cdd:COG3852 158 QLlereLPDDELREYTQLIieeadrlnnlvdrllsfsrprpPEREPVNLHEVLERVLELLRAEAPKNIR--IVRD----- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 406 vncstqvPNSEDPAVTHD---LITVIGNLLNNALDAVShtENKNISISFRYV----------QEQLHIEITDTGVGLTKE 472
Cdd:COG3852 231 -------YDPSLPEVLGDpdqLIQVLLNLVRNAAEAMP--EGGTITIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEE 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 473 EQDIMFDQGFSTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKEDSH 532
Cdd:COG3852 302 ILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
170-524 |
1.95e-25 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 108.51 E-value: 1.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 170 LLPLYFVTSLSLLSGIIGALIVARKV----KKIMFGLE---------------PDEIATL----------LKERS----- 215
Cdd:COG5000 8 LLLLLLIALLLLLLALWLALLLARRLtrplRRLAEATRavaagdlsvrlpvtgDDEIGELarafnrmtdqLKEQReelee 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 216 ------AMLESTKEGILAVDQHGKIKLANAEAKRLFHnmgimVDPRE---QDVQALLPSSGLKQVIE-TRKPLLDRDVRM 285
Cdd:COG5000 88 rrryleTILENLPAGVIVLDADGRITLANPAAERLLG-----IPLEEligKPLEELLPELDLAELLReALERGWQEEIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 286 NGLELVFNEVPITVKGEIvGAIATFRDKTEVKHlAEQLSgvkmyanALR--AQ--SHEFMNKLHVILGLVQLKNYDDLGT 361
Cdd:COG5000 163 TRDGRRTLLVRASPLRDD-GYVIVFDDITELLR-AERLA-------AWGelARriAHEIKNPLTPIQLSAERLRRKLADK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 362 YIKDIAIYQQTeTNEIINHVK-------------------------NSVLAGFLLGKQSYIREQGAALEVNCstqvpNSE 416
Cdd:COG5000 234 LEEDREDLERA-LDTIIRQVDrlkrivdefldfarlpepqlepvdlNELLREVLALYEPALKEKDIRLELDL-----DPD 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 417 DPAVTHD---LITVIGNLLNNALDAVShtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFGL 493
Cdd:COG5000 308 LPEVLADrdqLEQVLINLLKNAIEAIE--EGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGL 385
|
410 420 430
....*....|....*....|....*....|.
gi 515937370 494 YFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG5000 386 AIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| sCache_3_2 |
pfam17203 |
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ... |
36-170 |
1.71e-24 |
|
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435783 [Multi-domain] Cd Length: 140 Bit Score: 99.02 E-value: 1.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 36 KNIHQQERDIALSTAKMVAEAPITAKSLEKDQSYTALRKYTTSVQRITKTEFVVVMDMNGIRKTHPNPQKIGKRFAGGDE 115
Cdd:pfam17203 4 ADLTRQLERRALALARSVAASPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSGPAT 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 515937370 116 KPALQ-GKEHISTASGTLGKSMRAFVPVYNQDGKQLGAVAVGITLKEIDLIIHQSL 170
Cdd:pfam17203 84 APALTaGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQDSITAALRELL 139
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
337-524 |
5.54e-23 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 99.98 E-value: 5.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 337 SHEFMNKLHVILGLVQL-----------------KNYDDLGTYIKDIAIYQQTETNEIINHVK----NSVLAGFLLGKQS 395
Cdd:COG0642 118 SHELRTPLTAIRGYLELlleeldeeqreyletilRSADRLLRLINDLLDLSRLEAGKLELEPEpvdlAELLEEVVELFRP 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 396 YIREQGAALEVNCSTQVPNSE-DPavtHDLITVIGNLLNNALDavsHT-ENKNISISFRYVQEQLHIEITDTGVGLTKEE 473
Cdd:COG0642 198 LAEEKGIELELDLPDDLPTVRgDP---DRLRQVLLNLLSNAIK---YTpEGGTVTVSVRREGDRVRISVEDTGPGIPPED 271
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 515937370 474 QDIMFDQGFSTKGEDR----GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG0642 272 LERIFEPFFRTDPSRRgggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
338-524 |
2.48e-22 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 98.72 E-value: 2.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 338 HEFMNKLHVILGLVQ-LKNY-------DDLGTYIKDIAiyQQTE-TNEIINHVKN-------------------SVLAgf 389
Cdd:COG4191 151 HEINNPLAAILGNAElLRRRledepdpEELREALERIL--EGAErAAEIVRSLRAfsrrdeeerepvdlnelidEALE-- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 390 LLgkQSYIREQGAALEVNCSTQVPNSEdpAVTHDLITVIGNLLNNALDAVSHTENKNISISFRYVQEQLHIEITDTGVGL 469
Cdd:COG4191 227 LL--RPRLKARGIEVELDLPPDLPPVL--GDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGI 302
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 515937370 470 TKEEQDIMFDQGFSTKGEDR--GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG4191 303 PPEVLERIFEPFFTTKPVGKgtGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
424-526 |
8.70e-22 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 90.40 E-value: 8.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVShtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDR-----GFGLYFVDQ 498
Cdd:smart00387 6 LRQVLSNLLDNAIKYTP--EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83
|
90 100
....*....|....*....|....*...
gi 515937370 499 SIKKLNGHMIVTSEKGEGTTFSLRIPYK 526
Cdd:smart00387 84 LVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
330-524 |
1.04e-20 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 91.12 E-value: 1.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 330 ANALRAQ-----SHEFMNKLHVILGLVQ-LKNYDD-------------------LGTYIKDIAIYQQTETNEIINHVK-- 382
Cdd:COG2205 12 LERLKSEflanvSHELRTPLTSILGAAElLLDEEDlspeerrelleiiresaerLLRLIEDLLDLSRLESGKLSLELEpv 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 383 --NSVLAGFLLGKQSYIREQGAALEVNCstqvpNSEDPAVTHD---LITVIGNLLNNALDavsHT-ENKNISISFRYVQE 456
Cdd:COG2205 92 dlAELLEEAVEELRPLAEEKGIRLELDL-----PPELPLVYADpelLEQVLANLLDNAIK---YSpPGGTITISARREGD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515937370 457 QLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDR----GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG2205 164 GVRISVSDNGPGIPEEELERIFERFYRGDNSRGeggtGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
423-527 |
3.30e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 85.88 E-value: 3.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 423 DLITVIGNLLNNALDAVSHTENKNISISfryVQEQLHIEITDTGVGLTKEEQDIMFD---QGFSTKGEDRGFGLYFVDQS 499
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAAKAGEITVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEpfsTADKRGGGGTGLGLSIVRKL 81
|
90 100
....*....|....*....|....*...
gi 515937370 500 IKKLNGHMIVTSEKGEGTTFSLRIPYKQ 527
Cdd:pfam02518 82 VELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
202-324 |
4.34e-18 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 86.75 E-value: 4.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 202 LEPDEIATLLKersAMLESTKEGILAVDQHGKIKLANAEAKRLFHnmgimVDPRE---QDVQALLPSSGLKQVIETRKPL 278
Cdd:COG3829 4 LELKELEEELE---AILDSLDDGIIVVDADGRITYVNRAAERILG-----LPREEvigKNVTELIPNSPLLEVLKTGKPV 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 515937370 279 LDRDVRMNG--LELVFNEVPITVKGEIVGAIATFRDKTEVKHLAEQLS 324
Cdd:COG3829 76 TGVIQKTGGkgKTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLR 123
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
159-528 |
6.94e-17 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 82.68 E-value: 6.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 159 LKEIDLIIHQSLLPLYFVTSLSLLSGIIGALIVARKVKKIMFGLEPDEIATLLKERSAMLESTKEGILAVDQHGKIKLAN 238
Cdd:COG5002 1 LLLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 239 AEAKRLFHNMGIMVDPREQDVQALLPSSGLKQVIETRKPLLDRDVRMNGLELVFNEVPITVKGEIVGAIATFRDKTEVKH 318
Cdd:COG5002 81 LALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 319 LAEQLSgvKMYANAlraqSHEFMNKLHVILGLVQL--------------------KNYDDLGTYIKDIAIYQQTETNEII 378
Cdd:COG5002 161 LEQMRR--EFVANV----SHELRTPLTSIRGYLELlldgaaddpeerreyleiilEEAERLSRLVNDLLDLSRLESGELK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 379 NHVKNSVLAGFLLGKQSYIREQGAALEVNCSTQVPnSEDPAVTHD---LITVIGNLLNNAldaVSHT-ENKNISISFRYV 454
Cdd:COG5002 235 LEKEPVDLAELLEEVVEELRPLAEEKGIELELDLP-EDPLLVLGDpdrLEQVLTNLLDNA---IKYTpEGGTITVSLREE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 455 QEQLHIEITDTGVGLTKEEQDIMFDQgFST--KGEDR-----GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQ 527
Cdd:COG5002 311 DDQVRISVRDTGIGIPEEDLPRIFER-FYRvdKSRSRetggtGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
.
gi 515937370 528 K 528
Cdd:COG5002 390 E 390
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
218-529 |
3.33e-16 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 81.17 E-value: 3.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 218 LESTKEGILAVDQHGKIKLANAEAKRLFhNMGImVDPREQDVQALLPS-------SGLKQVIETRKPLL--DRDVRMNG- 287
Cdd:COG5809 147 FNHSPDGIIVTDLDGRIIYANPAACKLL-GISI-EELIGKSILELIHSddqenvaAFISQLLKDGGIAQgeVRFWTKDGr 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 288 -LELVFNEVPITVKGEIVGAIATFRDKTEVKHLAEQL-------------SGVkmyanalraqSHEFMNKLHVILGLVQL 353
Cdd:COG5809 225 wRLLEASGAPIKKNGEVDGIVIIFRDITERKKLEELLrkseklsvvgelaAGI----------AHEIRNPLTSLKGFIQL 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 354 KNYDDLG---TYIkDIAIyqqTETNEIinhvkNSVLAGFL-LGK-----------QSYIRE-----QGAALEVNCSTQVP 413
Cdd:COG5809 295 LKDTIDEeqkTYL-DIML---SELDRI-----ESIISEFLvLAKpqaikyepkdlNTLIEEvipllQPQALLKNVQIELE 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 414 NSED-PAVTHD---LITVIGNLLNNALDAVShtENKNISIS-FRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGED 488
Cdd:COG5809 366 LEDDiPDILGDenqLKQVFINLLKNAIEAMP--EGGNITIEtKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKG 443
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 515937370 489 RGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKE 529
Cdd:COG5809 444 TGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSE 484
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
427-524 |
1.40e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 67.13 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 427 VIGNLLNNAldaVSHTENKNISISFRYV-----QEQLHIEITDTGVGLTKEEQDIMF------DQGFSTKGEDRGFGLYF 495
Cdd:cd16922 4 ILLNLLGNA---IKFTEEGEVTLRVSLEeeeedGVQLRFSVEDTGIGIPEEQQARLFepfsqaDSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 515937370 496 VDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
369-526 |
2.12e-13 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 72.13 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 369 YQQTETNEIINHVKNSVlagfllgkQSYIREQGAALEVNCSTQVPnsEDPAVTHDLITVIGNLLNNALDAVShtENKNIS 448
Cdd:PRK10364 304 LQAVDLNDLINHSLQLV--------SQDANSREIQLRFTANDTLP--EIQADPDRLTQVLLNLYLNAIQAIG--QHGVIS 371
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515937370 449 ISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYK 526
Cdd:PRK10364 372 VTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 449
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
385-515 |
7.36e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 65.68 E-value: 7.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 385 VLAGFLLGKQSYIREQGaaLEVNCSTQVPNSeDPAVTHDLITVIGNLLNNALDAVS--HTENKNISISFRYVQEQLHIEI 462
Cdd:cd16935 1 ALDSLLSEKLELAREKG--IEFTIEIDIPIL-LPISPLDLCIIFGNLLDNAIEACAkiDKENRFIHLKIRQKKGFLIISI 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515937370 463 TDTgvglTKEEQDIMFDQGFSTKGE-DRGFGLYFVDQSIKKLNGHMIVTSEKGE 515
Cdd:cd16935 78 ENS----YEGELKKKNGLFLSTKKDkNHGIGLKSIREIVKKYNGNLSIEYENGI 127
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
332-528 |
1.39e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 69.66 E-value: 1.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 332 ALRAQS--HEFMNKLHVILGLVQLKNYDDLGTYIKDIAIY--------QQTETNEI-INHVKNsvlagFLLGKQsyIR-E 399
Cdd:COG2972 246 ALQAQInpHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLlryslskgDELVTLEEeLELIKS-----YLEIQK--LRfG 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 400 QGAALEVNCSTQVPNSEDPAVThdlitvIGNLLNNAldaVSH-----TENKNISISFRYVQEQLHIEITDTGVGLTKEEQ 474
Cdd:COG2972 319 DRLEVEIEIDEELLDLLIPKLI------LQPLVENA---IEHgiepkEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKL 389
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 515937370 475 DIMFdQGFSTKGEDRGFGLYFVDQSIKKLNG---HMIVTSEKGEGTTFSLRIPYKQK 528
Cdd:COG2972 390 EKLL-EELSSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
422-523 |
1.20e-11 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 61.08 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 422 HDLITVIGNLLNNALDAVSHT-ENKNISISFRYVQEQLHIEITDtgvglTKEEQDIMFDQGFSTK--GEDRGFGLYFVDQ 498
Cdd:pfam14501 4 VDLCVIFGNLLDNAIEACSKIdDNRFIRLKIREKQNFLIIRIEN-----TYEGELKFEGKLPSTKtkGDGHGIGLKSIRR 78
|
90 100
....*....|....*....|....*
gi 515937370 499 SIKKLNGHMIVTSEKGEgttFSLRI 523
Cdd:pfam14501 79 IVKKYGGNLSTEIENGI---FTLSI 100
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
426-524 |
2.41e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 60.86 E-value: 2.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 426 TVIGNLLNNALDAVSHTENKNISISFRYVQEQ-------------LHIEITDTGVGLTKEEQDIMFDQGFSTKGEDR--G 490
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETSNQRVDADyalnyrdlipgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKgtG 82
|
90 100 110
....*....|....*....|....*....|....
gi 515937370 491 FGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16919 83 LGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-521 |
4.33e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.78 E-value: 4.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTK--GEDRGFGLYFVDQSIK 501
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|
gi 515937370 502 KLNGHMIVTSEKGEGTTFSL 521
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTF 100
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
319-528 |
4.35e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 63.10 E-value: 4.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 319 LAEQLSGVKMYANALRAQSHEFMNKLHVILGLvqlknyddlgtyIKDIAIYQQTETNEIINHVKNSVLAGFLLGK--QSY 396
Cdd:COG4585 65 VGQSLSAIKLQLEAARRLLDADPEAAREELEE------------IRELAREALAELRRLVRGLRPPALDDLGLAAalEEL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 397 IREQGAALEVNCSTQVPNSE---DPAVTHDLITVIGNLLNNAldaVSHTENKNISISFRYVQEQLHIEITDTGVGltkee 473
Cdd:COG4585 133 AERLLRAAGIRVELDVDGDPdrlPPEVELALYRIVQEALTNA---LKHAGATRVTVTLEVDDGELTLTVRDDGVG----- 204
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 515937370 474 qdimFDQGFSTKGedrGFGLyfvdQSIKK----LNGHMIVTSEKGEGTTFSLRIPYKQK 528
Cdd:COG4585 205 ----FDPEAAPGG---GLGL----RGMREraeaLGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-524 |
8.03e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 58.97 E-value: 8.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVShtENKNISI-SFRYVQEQLhIEITDTGVGLTKEEQDIMFDQGFSTK--GEDRGFGLYFVDQSI 500
Cdd:cd16943 4 LNQVLLNLLVNAAQAME--GRGRITIrTWAHVDQVL-IEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....
gi 515937370 501 KKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-524 |
2.63e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 57.68 E-value: 2.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVShtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTK-----GEDRGFGLYFVDQ 498
Cdd:cd16948 6 LSFIIGQIVSNALKYSK--QGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 515937370 499 SIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
417-524 |
4.19e-10 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 58.75 E-value: 4.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 417 DPAVTHDLITVIGNLLNNALD----------AVSHTENKNISISFRYVQEQLHIEITDTGVGLTKE-------------- 472
Cdd:cd16916 32 DKSVLEKLADPLTHLLRNAVDhgieapeerlAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREkirekaierglita 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515937370 473 -------EQDI---MFDQGFSTKGE-----DRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16916 112 deaatlsDDEVlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
427-524 |
4.46e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 57.02 E-value: 4.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 427 VIGNLLNNALDAVSHT--ENKNISISF-----RYVQeqlhIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFGLYFVDQS 499
Cdd:cd16920 4 VLINLVRNGIEAMSEGgcERRELTIRTspaddRAVT----ISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSI 79
|
90 100
....*....|....*....|....*
gi 515937370 500 IKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16920 80 IEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
250-524 |
7.43e-10 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 61.34 E-value: 7.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 250 IMVDPREQDVQALLPSSGLKQVIETRKPLLDRDVRMNGLELVFNEVPITVKGEIVGAIATFRDKTEVKHLAEQLsgvKMY 329
Cdd:COG4251 195 LLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEEL---EER 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 330 ANALRAQ-----------SHEFMNKLHVILGLVQL--KNYDD-------------------LGTYIKDIAIYQQTETNEI 377
Cdd:COG4251 272 TAELERSneeleqfayvaSHDLREPLRKISGFSQLleEDYGDkldeegreylerirdaaerMQALIDDLLAYSRVGRQEL 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 378 ------INHVKNSVLAGFllgkQSYIREQGAALEVncstqvpnSEDPAVTHD---LITVIGNLLNNALDAVSHTENKNIS 448
Cdd:COG4251 352 efepvdLNELLEEVLEDL----EPRIEERGAEIEV--------GPLPTVRGDptlLRQVFQNLISNAIKYSRPGEPPRIE 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 449 ISFRYVQEQLHIEITDTGVGLTKEEQDIMFD--QGFSTKGEDR--GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG4251 420 IGAEREGGEWVFSVRDNGIGIDPEYAEKIFEifQRLHSRDEYEgtGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
427-524 |
2.05e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 60.34 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 427 VIGNLLNNAldaVSHTENKNISISFRYVQEQ-LHIEITDTGVGLTKEEQDIMFD---QGFSTKGEDR----GFGLYFVDQ 498
Cdd:PRK11091 402 ILWNLISNA---VKFTQQGGVTVRVRYEEGDmLTFEVEDSGIGIPEDELDKIFAmyyQVKDSHGGKPatgtGIGLAVSKR 478
|
90 100
....*....|....*....|....*.
gi 515937370 499 SIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK11091 479 LAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
447-524 |
1.20e-08 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 57.50 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 447 ISISFRYVQEQLHIEITDTGVGL---------------TKEEQDIMFDQ---------GFSTKGED-----RGFGLYFVD 497
Cdd:COG0643 311 ITLSAYHEGGRVVIEVSDDGRGLdlekirakaiekgliTAEEAAALSDEellelifapGFSTAEEVtdlsgRGVGMDVVK 390
|
90 100
....*....|....*....|....*..
gi 515937370 498 QSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG0643 391 TNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
216-524 |
1.56e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 57.05 E-value: 1.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 216 AMLESTKEGILAVDQHGKIKLANAEAKRLF----------HNMGIMVDPREQDVQALLPS-SGLKQVIETRKPLLDRDVR 284
Cdd:COG5805 161 TLIENSPDLICVIDTDGRILFINESIERLFgapreeligkNLLELLHPCDKEEFKERIESiTEVWQEFIIEREIITKDGR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 285 MNGLELVFneVP-ITVKGEIVGAIATFRDKTEVKHLAEQLSGVKMYANA--LRAQ-SHEFMNKLHVILGLVQLknyddLG 360
Cdd:COG5805 241 IRYFEAVI--VPlIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAgqLAAGiAHEIRNPLTSIKGFLQL-----LQ 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 361 TYIKDIAIYQQTETNEIINhvKNSVLAGFL-LGK-----------QSYIREQGAALEVNCSTQ------VPNSEDPAVTH 422
Cdd:COG5805 314 PGIEDKEEYFDIMLSELDR--IESIISEFLaLAKpqavnkekeniNELIQDVVTLLETEAILHniqirlELLDEDPFIYC 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 423 D---LITVIGNLLNNALDAVShtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFGLYFVDQS 499
Cdd:COG5805 392 DenqIKQVFINLIKNAIEAMP--NGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKI 469
|
330 340
....*....|....*....|....*
gi 515937370 500 IKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:COG5805 470 IENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
333-526 |
6.34e-08 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 55.68 E-value: 6.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 333 LRAQSHEFMNKLHVILGLVQL-------KNYDD-----------LGTYIKDIAIYQQTE---TNEIINH---VKNSVLAG 388
Cdd:PRK11466 448 LAAMSHEIRTPLYGILGTAQLladnpalNAQRDdlraitdsgesLLTILNDILDYSAIEaggKNVSVSDepfEPRPLLES 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 389 FLLGKQSYIREQGAALEVNCSTQVPNS--EDPAVTHDLITvigNLLNNALdavSHTENKNISISFRYVQEQLHIEITDTG 466
Cdd:PRK11466 528 TLQLMSGRVKGRPIRLATDIADDLPTAlmGDPRRIRQVIT---NLLSNAL---RFTDEGSIVLRSRTDGEQWLVEVEDSG 601
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515937370 467 VGLTKEEQDIMFdQGF---STKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYK 526
Cdd:PRK11466 602 CGIDPAKLAEIF-QPFvqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
430-524 |
6.59e-08 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 55.42 E-value: 6.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 430 NLLNNAldaVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDR--GFGLYFVDQSIKKLNGHM 507
Cdd:PRK15347 520 NLLGNA---VKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQgtGLGLTIASSLAKMMGGEL 596
|
90
....*....|....*..
gi 515937370 508 IVTSEKGEGTTFSLRIP 524
Cdd:PRK15347 597 TLFSTPGVGSCFSLVLP 613
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
430-524 |
1.11e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 54.29 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 430 NLLNNALDAVSH-------TENKNIS----------ISFRYVQeqlhIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFG 492
Cdd:PRK13557 284 NVLINARDAMPEggrvtirTRNVEIEdedlamyhglPPGRYVS----IAVTDTGSGMPPEILARVMDPFFTTKEEGKGTG 359
|
90 100 110
....*....|....*....|....*....|....*...
gi 515937370 493 L-----Y-FVDQSikklNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK13557 360 LglsmvYgFAKQS----GGAVRIYSEVGEGTTVRLYFP 393
|
|
| SPOB_a |
pfam14689 |
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ... |
332-373 |
2.05e-07 |
|
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.
Pssm-ID: 434130 [Multi-domain] Cd Length: 62 Bit Score: 48.01 E-value: 2.05e-07
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 515937370 332 ALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTE 373
Cdd:pfam14689 15 ALRHQRHDFLNHLQVISGYLQLGRYDRAEEYIKEVVKDLKEE 56
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
403-524 |
3.94e-07 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 53.20 E-value: 3.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 403 ALEVNCSTQVPNSE----DPAVthdLITVIGNLLNNALDAVSHTENKnISISFRYVQEQ---LHIEITDTGVGLTKEEQD 475
Cdd:PRK09959 807 SIALSCSSTFPDHYlvkiDPQA---FKQVLSNLLSNALKFTTEGAVK-ITTSLGHIDDNhavIKMTIMDSGSGLSQEEQQ 882
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515937370 476 IMFDQgFSTKGEDR-----GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK09959 883 QLFKR-YSQTSAGRqqtgsGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
417-524 |
9.19e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.99 E-value: 9.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 417 DPAVTHDLITVIGNLLNNALD-AVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEqdimFDQGFSTKGEdRGFGLYF 495
Cdd:COG2172 28 DEDDADDLVLAVSEAVTNAVRhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPED----LPDPYSTLAE-GGRGLFL 102
|
90 100
....*....|....*....|....*....
gi 515937370 496 vdqsIKKLNGHMIVTSEKGeGTTFSLRIP 524
Cdd:COG2172 103 ----IRRLMDEVEYESDPG-GTTVRLVKR 126
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-524 |
1.06e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 47.32 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFD--QGFSTKG--EDRGFGLYFVDQS 499
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGifQRLHSREeyEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 515937370 500 IKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-523 |
2.23e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 46.30 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVShtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFS-----TKGEDRGFGLYFVDQ 498
Cdd:cd16975 5 LSRALINIISNACQYAP--EGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRddtsrRSGGHYGMGLYIAKN 82
|
90 100
....*....|....*....|....*
gi 515937370 499 SIKKLNGHMIVTSEKGEGTTFSLRI 523
Cdd:cd16975 83 LVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
432-524 |
2.24e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 45.62 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 432 LNNALdavSHTENKNISISFRYVQEQLHIEITDTGVGLTKEeqdimfdqgfsTKGEDRGFGLYFVDQSIKKLNGHMIVTS 511
Cdd:cd16917 9 LTNAL---KHAGASRVRVTLSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGS 74
|
90
....*....|...
gi 515937370 512 EKGEGTTFSLRIP 524
Cdd:cd16917 75 RPGGGTRVTARLP 87
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
431-530 |
2.28e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 431 LLNNALD-AVSHTENKNISISFRYVQEQLHIEITDTGVGltkeeqdimFDQGFSTKgEDRGFGLYFVDQSIKKLNGHMIV 509
Cdd:COG3920 407 LVTNALKhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVG---------LPEDVDPP-ARKGLGLRLIRALVRQLGGTLEL 476
|
90 100
....*....|....*....|.
gi 515937370 510 TSEkgEGTTFSLRIPYKQKED 530
Cdd:COG3920 477 DRP--EGTRVRITFPLAELAA 495
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
427-524 |
2.33e-06 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 50.36 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 427 VIGNLLNNAldaVSHTENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFD------QGFSTKGEDRGFGLYFVDQSI 500
Cdd:PRK10841 566 VISNLLSNA---IKFTDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDpffqvgTGVQRNFQGTGLGLAICEKLI 642
|
90 100
....*....|....*....|....
gi 515937370 501 KKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK10841 643 NMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
456-530 |
3.16e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 49.93 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 456 EQLHIEITDTGVGLTKEEQDIMfDQGFSTKG-EDR-----GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQKE 529
Cdd:PRK10618 598 DRLTIRILDTGAGVSIKELDNL-HFPFLNQTqGDRygkasGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLAAD 676
|
.
gi 515937370 530 D 530
Cdd:PRK10618 677 P 677
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
141-340 |
5.00e-06 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 49.29 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 141 PVYNQDGKQLGAVAVGItlkeidLIIHQSllplyfVTSLSLlsgiigALIVARKV-KKIMFGLEPDEIATLLKERSAMLE 219
Cdd:PRK11388 149 PVFDSKGRLTGTIALAC------PVEQTS------AADLPL------TLSIAREVgNLLLTDSLLAESNRHLNQLNALLE 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 220 STKEGILAVDQHGKIKLANAEAKRLFHnmgimvdpreqdvqaLLPSSGLKQVIE---TRKPLLDRDVRM-NGLELVfnEV 295
Cdd:PRK11388 211 SMDDGVIAWDEQGNLQFLNAQAARLLR---------------LDATASQGRAITellTLPAVLQQAIKQaHPLKHV--EV 273
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 515937370 296 PITVKGEIVGAIATFR---DKTEVKHLA-----EQLSgvKMYANALRAQSHEF 340
Cdd:PRK11388 274 TFESQGQFIDAVITLKpiiEGQGTSFILllhpvEQMR--QLMTSQLGKVSHTF 324
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
398-524 |
7.36e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 48.69 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 398 REQGAALEVNCSTQVPNSedpaVTHD---LITVIGNLLNNAldaVSHTENKNISISFRYV-----QEQLHIEITDTGVGL 469
Cdd:PRK11107 384 HEKGLELTLNIDPDVPDN----VIGDplrLQQIITNLVGNA---IKFTESGNIDILVELRalsntKVQLEVQIRDTGIGI 456
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515937370 470 TKEEQDIMF------DQGFSTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK11107 457 SERQQSQLFqafrqaDASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-524 |
1.08e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 44.31 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNALDAVSHTENKnISISFRYvQEQ-----------LHIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFG 492
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGE-IILRTRT-QRQvtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 515937370 493 LYFVDQSIKKLNGHMIVTSEKGEgTTFSLRIP 524
Cdd:cd16918 79 LAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
406-523 |
1.32e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 44.93 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 406 VNCSTQVPnsedPAVT-----HDLITVIGNLLNNALD-AVSHTEnknisISFRYVQEQLHIEITDTGVGLTKEEQDIMFD 479
Cdd:cd16954 19 VSISLDIS----PELRfpgerNDLMELLGNLLDNACKwCLEFVE-----VTARQTDGGLHLIVDDDGPGVPESQRSKIFQ 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 515937370 480 QGF----STKGEdrGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRI 523
Cdd:cd16954 90 RGQrldeQRPGQ--GLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
216-323 |
2.28e-05 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 43.82 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 216 AMLESTKEGILAVDQHGKIKLANAEAKRLF---------HNMGIMVDPREQDVqallpssgLKQVIETRKPLLDRDVRM- 285
Cdd:TIGR00229 7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFgysaeeligRNVLELIPEEDREE--------VRERIERRLEGEPEPVSEe 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 515937370 286 ------NGLELVF--NEVPITVKGEIVGAIATFRDKTEVKHLAEQL 323
Cdd:TIGR00229 79 rrvrrkDGSEIWVevSVSPIRTNGGELGVVGIVRDITERKEAEEAL 124
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
212-312 |
3.28e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 43.17 E-value: 3.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 212 KERSAMLESTKEGILAVDQHGKIKLANAEAKRLFH-----NMGIM-VDPREQDVQALLPSSgLKQVIETRKPLLDRDVR- 284
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGlsreeVIGKSlLDLIPEEDDAEVAEL-LRQALLQGEESRGFEVSf 79
|
90 100 110
....*....|....*....|....*....|...
gi 515937370 285 ----MNGLELVFNEVPIT-VKGEIVGAIATFRD 312
Cdd:pfam00989 80 rvpdGRPRHVEVRASPVRdAGGEILGFLGVLRD 112
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-527 |
5.17e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 42.57 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 424 LITVIGNLLNNAldaVSHT-ENKNISISFRYVQEQLHIEITDTGVGLTKE------EQDIMFDQGFSTKGEDRGFGLYFV 496
Cdd:cd16952 1 LRSAFSNLVSNA---VKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEhiprltERFYRVDIERCRNTGGTGLGLAIV 77
|
90 100 110
....*....|....*....|....*....|.
gi 515937370 497 DQSIKKLNGHMIVTSEKGEGTTFSLRIPYKQ 527
Cdd:cd16952 78 KHVMSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-524 |
4.46e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 40.48 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 376 EIINHVKNSVLAGFLLGKQSyIREQGAALEVNCSTQVPnsedpavthdLITVIGNLLNNALD-AVSHTENKNISISFRYV 454
Cdd:cd16951 3 EYINRIASAINAIHAVGDIR-INITGDTGPVSSEVATA----------IGLVVNELLQNALKhAFSDREGGTITIRSVVD 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 455 QEQLHIEITDTGVGltkeeqdimFDQGFsTKGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16951 72 GDYLRITVIDDGVG---------LPQDE-DWPNKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
216-323 |
6.45e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 41.55 E-value: 6.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 216 AMLESTKEGILAVDQHGKIKLANAEAKRLF----------HNMGIMVDPREQDVQALLPS--SGLKQVIETRKPLLDRDV 283
Cdd:COG2202 141 LLVENAPDGIFVLDLDGRILYVNPAAEELLgyspeellgkSLLDLLHPEDRERLLELLRRllEGGRESYELELRLKDGDG 220
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 515937370 284 RMNGLELvfNEVPITVKGEIVGAIATFRDKTEVKHLAEQL 323
Cdd:COG2202 221 RWVWVEA--SAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
427-524 |
8.20e-04 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 42.36 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 427 VIGNLLNNA-------------LDAVSHTENKNISISF----RYVQeqlhIEITDTGVGLTKEEQDIMFDQGFSTKGEDR 489
Cdd:PRK13837 564 VLMNLCSNAaqamdgagrvdisLSRAKLRAPKVLSHGVlppgRYVL----LRVSDTGAGIDEAVLPHIFEPFFTTRAGGT 639
|
90 100 110
....*....|....*....|....*....|....*
gi 515937370 490 GFGLYFVDQSIKKLNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK13837 640 GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| PRK10547 |
PRK10547 |
chemotaxis protein CheA; Provisional |
386-524 |
9.95e-04 |
|
chemotaxis protein CheA; Provisional
Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 42.02 E-value: 9.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 386 LAGfLLGKQSYIREQGAALEVNCSTqVPNSEDPaVTHdlitvignLLNNALD----------AVSHTENKNISISFRYVQ 455
Cdd:PRK10547 359 LAG-KLGKQVELTLVGSSTELDKSL-IERIIDP-LTH--------LVRNSLDhgielpekrlAAGKNSVGNLILSAEHQG 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 456 EQLHIEITDTGVGLTKEE------------QDIM---------FDQGFST--KGED---RGFGLYFVDQSIKKLNGHMIV 509
Cdd:PRK10547 428 GNICIEVTDDGAGLNRERilakaasqglavSENMsdeevgmliFAPGFSTaeQVTDvsgRGVGMDVVKRNIQEMGGHVEI 507
|
170
....*....|....*
gi 515937370 510 TSEKGEGTTFSLRIP 524
Cdd:PRK10547 508 QSKQGKGTTIRILLP 522
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
213-311 |
1.35e-03 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 41.33 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 213 ERSAMLESTKEGILAVDQHGKIKLANAEAKRLFhnmGIMVDP-REQDVQALLPSSGLKQVIETRKPLL-DRDVRMNGLEL 290
Cdd:COG3283 81 ELDALLEALPDPVFSIDLKGKIELANPAALSLL---GLSEEElIGQPLSELLKGFNFSRWLESNEPRPqSERVVINGQDY 157
|
90 100
....*....|....*....|....*.
gi 515937370 291 VFNEVPITV-----KGEIVGAIATFR 311
Cdd:COG3283 158 LADILPIYLpdeegKSILAGAVVTLK 183
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
427-524 |
1.37e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 38.29 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 427 VIGNLLNNALDAVSHTENKNISISFRY---VQEQLHIEITDTGVGLTKEEQDIMFDQGFSTKGEDRGFGLYFVDQSIKKL 503
Cdd:cd16944 8 VLTNILKNAAEAIEGRPSDVGEVRIRVeadQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEH 87
|
90 100
....*....|....*....|.
gi 515937370 504 NGHMIVTSEKGEGTTFSLRIP 524
Cdd:cd16944 88 GGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
428-507 |
1.89e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 37.83 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 428 IGNLLNNALDAVShtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFS-----TKGEDRGFGLYFVDQSIKK 502
Cdd:cd16945 9 INNLLDNAIDFSP--EGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQL 86
|
....*
gi 515937370 503 LNGHM 507
Cdd:cd16945 87 HGGRI 91
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
418-526 |
1.92e-03 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 40.45 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 418 PAVTHD---LITVIGNLLNNALDAVSHtENKNISISFRYV-QEQLH---------IEITDTGVGLTKEEQDIMFDQGFST 484
Cdd:PRK11073 229 PELAHDpdqIEQVLLNIVRNALQALGP-EGGTITLRTRTAfQLTLHgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSG 307
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 515937370 485 KGEDRGFGLYFVDQSIKKLNGHMIVTSEKGEgTTFSLRIPYK 526
Cdd:PRK11073 308 REGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
423-511 |
2.91e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 40.39 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 423 DLITVIGNLLNNA----LDAVshtenkniSISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQG--FSTKGEDRGFGLYFV 496
Cdd:PRK10815 378 DFMEVMGNVLDNAckycLEFV--------EISARQTDEHLHIVVEDDGPGIPESKRELIFDRGqrADTLRPGQGLGLSVA 449
|
90
....*....|....*
gi 515937370 497 DQSIKKLNGHMIVTS 511
Cdd:PRK10815 450 REITEQYEGKISAGD 464
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
437-524 |
6.98e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 36.26 E-value: 6.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 437 DAVSH-----TENKNISISFRYVQEQLHIEITDTGVGLTKEeqdimfDQGFSTKGEDRGFGLYFVDQSIKKLNGH---MI 508
Cdd:cd16956 12 NAVKHglsglLDGGRVEITARLDGQHLLLEVEDNGGGMDPD------TLARILIRSSNGLGLNLVDKRLRQAFGNdygLD 85
|
90
....*....|....*.
gi 515937370 509 VTSEKGEGTTFSLRIP 524
Cdd:cd16956 86 IECAPGEGTRITIRLP 101
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
428-524 |
7.42e-03 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 39.06 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 428 IGNLLNNALDaVSHtENKNISISFRYVQEQLHIEITDTGVGLTKEEQDIMFDQGFST---KGEDR--GFGLYFVDQSIKK 502
Cdd:PRK11100 373 LGNLLDNAID-FSP-EGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLprpANGRKstGLGLAFVREVARL 450
|
90 100
....*....|....*....|..
gi 515937370 503 LNGHMIVTSEKGEGTTFSLRIP 524
Cdd:PRK11100 451 HGGEVTLRNRPEGGVLATLTLP 472
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
268-514 |
7.52e-03 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 38.90 E-value: 7.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 268 LKQVIETRKPLL----DRDVRMNGLELVFNEVPITVKGEIVGAIATfrdktEVKHLAEQ-LSGVKMYANALRAQshefmn 342
Cdd:COG4192 393 RDQAIEKTQELEteieERKRIEKNLRQTQDELIQAAKMAVVGQTMT-----SLAHELNQpLNAMSMYLFSAKKA------ 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 343 klhvilglVQLKNYDDLGTYIKDIAiYQQTETNEIIN----------------HVKNSVLAGFLLGKQSYIREQgaalev 406
Cdd:COG4192 462 --------LEQENYAQLPTSLDKIE-GLIERMDKIIKslrqfsrksdtplqpvDLRQVIEQAWELVESRAKPQQ------ 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515937370 407 nCSTQVPNseDPAVTHDLI---TVIGNLLNNALDAVshTENKNISISFRYVQEQLHIEITDTGVGLtkEEQDIMFDQGFS 483
Cdd:COG4192 527 -ITLHIPD--DLMVQGDQVlleQVLVNLLVNALDAV--ATQPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTT 599
|
250 260 270
....*....|....*....|....*....|...
gi 515937370 484 TKGEDRGFGLYFVDQSIKKLNGHMIV--TSEKG 514
Cdd:COG4192 600 TKEVGLGLGLSICRSIMQQFGGDLYLasTLERG 632
|
|
| |
