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Conserved domains on  [gi|516292863|ref|WP_017696170|]
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MULTISPECIES: penicillin-binding protein 2A [Bacillus]

Protein Classification

peptidoglycan D,D-transpeptidase FtsI family protein( domain architecture ID 11433609)

peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan

EC:  3.4.16.4
Gene Ontology:  GO:0009002|GO:0071555|GO:0016787|GO:0009252|GO:0008658|GO:0016020|GO:0051301|GO:0005886|GO:0008955
PubMed:  32762868|32442851|18266856|18248419

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 21-688 4.32e-136

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 412.30  E-value: 4.32e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  21 RLNILFLAAFVIFTWIIVELGIKQIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSttqE 100
Cdd:COG0768   13 RLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADPEEV---K 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 101 QRLKIAKKLSDMIKVDtkkvterdkkdywiltrPKEAKKLISSKERQQVedkkisdddlyqlqlkritdkqlneltdkdm 180
Cdd:COG0768   90 DPEETAEKLAKLLGLD-----------------PEELRKKLKKKSRFPV------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 181 qilaikrqmdsgyaltpqYIKnEDVSAKEMAVVseHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNeglpsnlldh 260
Cdd:COG0768  122 ------------------YLK-RNLSPEEAARI--RALKLPGVYVEAEYKRYYPYGELAAHVLGYVGEIN---------- 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 261 ylslgysRNDRVGKSYLEYQYESLLQGQKAKVENITDSNGNVTGT-KTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNLKS 339
Cdd:COG0768  171 -------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDlGEEKPPVPGKDLVLTIDSDLQKIAEEALKKAVEE 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 340 AKARpstqlldRAFVVMMDPRNGEVLSMAGKQIKQENGKYKIDDYALG--TMTSSYAMGSAVKGATVLTGLQTGAINLNT 417
Cdd:COG0768  244 YKAK-------SGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDEPLRnrAVQGTYEPGSTFKPFTAAAALEEGVITPDT 316

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 418 VFQDEP-LYIGQDKngKKSWTT--LGPVNIQRALEQSSNVFMFKTAIALGKgeykphqalpidttafDTFRNYFSQFGLG 494
Cdd:COG0768  317 TFDCPGyYRVGGRT--IRDWDRggHGTLTLTEALAKSSNVGFYKLALRLGI----------------DKLYDYLKKFGLG 378

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 495 VKTGIDLPNEMTGY-KGTDRLT-GFLLDYAIGQYDTYTPLELAQYVSTIANGGYRLKPQLVKEVREPDAKrgigavVQSV 572
Cdd:COG0768  379 QKTGIDLPGEASGLlPSPKRWYpGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGE------VVKE 452

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 573 QPEVLNKIdMKSEYIKEVQAGFRRVMTK--GTAASqFASASYQPAGKTGTAQSFYDGPDKSKTGtaTYNTTLVAYAPADN 650
Cdd:COG0768  453 EPEVLRRV-ISPETAETVREGMEGVVNEpgGTARR-AAIPGYRVAGKTGTAQVVDIGNGGYYKG--RHIASFVGFAPADN 528

                        650       660       670
                 ....*....|....*....|....*....|....*....
gi 516292863 651 PEIAISVVVPWA-YIDYSAkyTITNEIGREVMDKYFELK 688
Cdd:COG0768  529 PRYAVAVVVENPgGGAYGG--TVAAPVFREIMEAYLRLL 565
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 21-688 4.32e-136

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 412.30  E-value: 4.32e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  21 RLNILFLAAFVIFTWIIVELGIKQIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSttqE 100
Cdd:COG0768   13 RLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADPEEV---K 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 101 QRLKIAKKLSDMIKVDtkkvterdkkdywiltrPKEAKKLISSKERQQVedkkisdddlyqlqlkritdkqlneltdkdm 180
Cdd:COG0768   90 DPEETAEKLAKLLGLD-----------------PEELRKKLKKKSRFPV------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 181 qilaikrqmdsgyaltpqYIKnEDVSAKEMAVVseHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNeglpsnlldh 260
Cdd:COG0768  122 ------------------YLK-RNLSPEEAARI--RALKLPGVYVEAEYKRYYPYGELAAHVLGYVGEIN---------- 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 261 ylslgysRNDRVGKSYLEYQYESLLQGQKAKVENITDSNGNVTGT-KTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNLKS 339
Cdd:COG0768  171 -------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDlGEEKPPVPGKDLVLTIDSDLQKIAEEALKKAVEE 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 340 AKARpstqlldRAFVVMMDPRNGEVLSMAGKQIKQENGKYKIDDYALG--TMTSSYAMGSAVKGATVLTGLQTGAINLNT 417
Cdd:COG0768  244 YKAK-------SGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDEPLRnrAVQGTYEPGSTFKPFTAAAALEEGVITPDT 316

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 418 VFQDEP-LYIGQDKngKKSWTT--LGPVNIQRALEQSSNVFMFKTAIALGKgeykphqalpidttafDTFRNYFSQFGLG 494
Cdd:COG0768  317 TFDCPGyYRVGGRT--IRDWDRggHGTLTLTEALAKSSNVGFYKLALRLGI----------------DKLYDYLKKFGLG 378

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 495 VKTGIDLPNEMTGY-KGTDRLT-GFLLDYAIGQYDTYTPLELAQYVSTIANGGYRLKPQLVKEVREPDAKrgigavVQSV 572
Cdd:COG0768  379 QKTGIDLPGEASGLlPSPKRWYpGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGE------VVKE 452

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 573 QPEVLNKIdMKSEYIKEVQAGFRRVMTK--GTAASqFASASYQPAGKTGTAQSFYDGPDKSKTGtaTYNTTLVAYAPADN 650
Cdd:COG0768  453 EPEVLRRV-ISPETAETVREGMEGVVNEpgGTARR-AAIPGYRVAGKTGTAQVVDIGNGGYYKG--RHIASFVGFAPADN 528

                        650       660       670
                 ....*....|....*....|....*....|....*....
gi 516292863 651 PEIAISVVVPWA-YIDYSAkyTITNEIGREVMDKYFELK 688
Cdd:COG0768  529 PRYAVAVVVENPgGGAYGG--TVAAPVFREIMEAYLRLL 565
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 21-685 3.48e-104

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 330.25  E-value: 3.48e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863   21 RLNILFLAAFVIFTWIIVELGIKQIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKsttqe 100
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEK----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  101 qrlkiAKKLSDMIKvdtkkvterdkkdywiltrpkEAKKLISskerqqvedkkISDDDLyqlqlKRITDKqlneltdkdm 180
Cdd:TIGR03423  77 -----VDDLDATLD---------------------RLAKLLD-----------LDPEDI-----ARFLKE---------- 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  181 qilaIKRQmdSGYAltPQYIKnEDVSAKEMAVVSEHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEglpsNLLDH 260
Cdd:TIGR03423 105 ----LKRS--RRFE--PIPLK-SDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGYVGEINE----EDLER 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  261 YLSLGYSRNDRVGKSYLEYQYESLLQGQK--AKVEniTDSNGNVTGTKTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNlk 338
Cdd:TIGR03423 172 LEPANYAGGDYIGKSGIEKYYEDELRGKPgyREVE--VNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAAEKALGGR-- 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  339 sakarpstqlldRAFVVMMDPRNGEVLSMA----------GKQIKQENgkYKI----DDYAL--GTMTSSYAMGSAVKGA 402
Cdd:TIGR03423 248 ------------RGAVVVMDPRTGEILAMVstpsfdpnlfVDGISSKD--YKAllndPDRPLlnRAIQGVYPPGSTFKPV 313

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  403 TVLTGLQTGAINLNTVFQDePLYIgQDKNGK----KSWTTlGPVNIQRALEQSSNVFMFKTAIALGkgeykphqalpidt 478
Cdd:TIGR03423 314 VALAALEEGVITPETRIYC-PGYF-QLGGRRfrcwKRGGH-GRVDLRKAIEESCDVYFYQLALRLG-------------- 376

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  479 taFDTFRNYFSQFGLGVKTGIDLPNEMTG----------YKGTDRLTGFLLDYAIGQ-YDTYTPLELAQYVSTIANGGYR 547
Cdd:TIGR03423 377 --IDKIAEYAKRFGFGQKTGIDLPGEKSGlvpsrewkrkRFGQPWYPGDTLNVSIGQgYVLVTPLQLAVATAALANGGKL 454

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  548 LKPQLVKEVREPDakrgiGAVVQSVQPEVLNKIDMKSEYIKEVQAGFRRVMTK--GTAASQFASASYQPAGKTGTAQSFy 625
Cdd:TIGR03423 455 YKPHLVKSIEDPD-----GGVVRRTEPEVLRPLPISPENLDVVREGMRDVVNGpgGTARRARLGLPYKMAGKTGTAQVV- 528

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516292863  626 dgpdkSKTGTATYNTT-----------LVAYAPADNPEIAISVVV------PWAyidySAKytitneIGREVMDKYF 685
Cdd:TIGR03423 529 -----SLKQGEKYDAEqiperlrdhalFVAFAPYDNPKIAVAVIVehggggSSA----AAP------IARKIMDAYL 590
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 352-682 2.87e-82

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 263.12  E-value: 2.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  352 AFVVMMDPRNGEVLSMAGKQIKQENGKYkiDDYALGTMTSSYAMGSAVKGATVLTGLQTGAINLNTVFQDEPLYIGQDKN 431
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI--GPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGKQQGGKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  432 gKKSWTT--LGPVNIQRALEQSSNVFMFKTAIALGKgeykphqalpidttafDTFRNYFSQFGLGVKTGIDLPNEMTGYK 509
Cdd:pfam00905  79 -IGDWNQdqVGIGTLRQALEYSSNWYMQKLAQKLGA----------------DKLRSYLKKFGYGNKTGIGLPGENAGYL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  510 GTDRLTGFLLDYAIGqyDTYTPLELAQYVSTIANGGYRLKPQLVKevrepdakrgigAVVQSVQPEVLNKIDMKSEYIKE 589
Cdd:pfam00905 142 TPYWLEGATASFGIG--LTITPLQQAQAYAAIANGGKLVPPHLVK------------SIEDKVDPKVLNKLPISKSTAEK 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  590 VQAGFRRVMTKGTAASQFASASYQPAGKTGTAQSFydGPDKSKTGTATYNTTLVAYAPADNPEIAISVVVPWAYIDYSAK 669
Cdd:pfam00905 208 VKDMLRLVVNDGTGTGTAAVPGYKVAGKTGTAQVA--GPKGGGYYDGAQIGWFVGYAPADNPKYAFAVLIDDPKRYYGGK 285

                         330
                  ....*....|...
gi 516292863  670 ytITNEIGREVMD 682
Cdd:pfam00905 286 --VAAPIFKDILE 296
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 29-659 3.76e-41

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 159.55  E-value: 3.76e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  29 AFVIFTWIIVELGIK-------QIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIvtnkALNAITYtrsksttqeq 101
Cdd:PRK10795  22 ALVAFLGILLLTGVLianlynlQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL----ALNRTIY---------- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 102 RLKIAKKlsdmiKVDTKKVTERDkkdywiltrpkeakklisskerqqvedkkisdddlyqlqLKRITDkqlneLTDKDMQ 181
Cdd:PRK10795  88 QLEMMPE-----KVDNLQQTLDA---------------------------------------LRSVVD-----LTDDDIA 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 182 ILAIKRQMDSGYALTPQYIKNEDVSAKEMAVvseHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHY 261
Cdd:PRK10795 119 AFRKERARSRRFTSIPVKTNLTEVQVARFAV---NQYRFPGVEVKGYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEG 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 262 LSLGYSRNDRVGKSYLEYQYESLLQGQKAKVENITDSNGNVTGTKTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNlksak 341
Cdd:PRK10795 196 KLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQLHEQPPQAGHDIYLTLDLKLQQYIETLLAGS----- 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 342 arpstqlldRAFVVMMDPRNGEVLSMA------------GKQIKQENGKYKIDDYALGTMTSS--YAMGSAVKGATVLTG 407
Cdd:PRK10795 271 ---------RAAVVVTDPRTGGILALVstpsydpnlfvdGISSKDYSGLLNDPNRPLINRATQgvYPPASTVKPYVAVSA 341

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 408 LQTGAINLNTVFQDEPLYI--GQDKNGK--KSWTTlGPVNIQRALEQSSNVFMFKTAIALGkgeykphqalpidttaFDT 483
Cdd:PRK10795 342 LSAGVITRNTSLFDPGWWQlpGSEKRYRdwKKWGH-GRLNVTKSLEESADTFFYQVAYDMG----------------IDR 404

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 484 FRNYFSQFGLGVKTGIDLPNEMTGYKGTDR----------LTGFLLDYAIGQ-YDTYTPLELAQYVSTIANGGYRLKPQL 552
Cdd:PRK10795 405 LSEWMGKFGYGHYTGIDLAEERSGNMPTREwkqkrfkkpwYQGDTIPVGIGQgYWTATPIQMSKALMTLINDGIVKVPHL 484

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 553 VKEVREPdakrgiGAVVQSVQPEVLNKIDMKSEYIKEVQAGFRRVMTK--GTAASQFASASYQPAGKTGTAQSFydgpdk 630
Cdd:PRK10795 485 LMSTAED------GKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRpnGTAHKYFASAPYKIAAKSGTAQVF------ 552

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 516292863 631 SKTGTATYNTT-----------LVAYAPADNPEIAISVVV 659
Cdd:PRK10795 553 GLKANETYNAHkiaerlrdhklMTAFAPYNNPQVAVAIIL 592
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 21-688 4.32e-136

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 412.30  E-value: 4.32e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  21 RLNILFLAAFVIFTWIIVELGIKQIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSttqE 100
Cdd:COG0768   13 RLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADPEEV---K 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 101 QRLKIAKKLSDMIKVDtkkvterdkkdywiltrPKEAKKLISSKERQQVedkkisdddlyqlqlkritdkqlneltdkdm 180
Cdd:COG0768   90 DPEETAEKLAKLLGLD-----------------PEELRKKLKKKSRFPV------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 181 qilaikrqmdsgyaltpqYIKnEDVSAKEMAVVseHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNeglpsnlldh 260
Cdd:COG0768  122 ------------------YLK-RNLSPEEAARI--RALKLPGVYVEAEYKRYYPYGELAAHVLGYVGEIN---------- 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 261 ylslgysRNDRVGKSYLEYQYESLLQGQKAKVENITDSNGNVTGT-KTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNLKS 339
Cdd:COG0768  171 -------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDlGEEKPPVPGKDLVLTIDSDLQKIAEEALKKAVEE 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 340 AKARpstqlldRAFVVMMDPRNGEVLSMAGKQIKQENGKYKIDDYALG--TMTSSYAMGSAVKGATVLTGLQTGAINLNT 417
Cdd:COG0768  244 YKAK-------SGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDEPLRnrAVQGTYEPGSTFKPFTAAAALEEGVITPDT 316

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 418 VFQDEP-LYIGQDKngKKSWTT--LGPVNIQRALEQSSNVFMFKTAIALGKgeykphqalpidttafDTFRNYFSQFGLG 494
Cdd:COG0768  317 TFDCPGyYRVGGRT--IRDWDRggHGTLTLTEALAKSSNVGFYKLALRLGI----------------DKLYDYLKKFGLG 378

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 495 VKTGIDLPNEMTGY-KGTDRLT-GFLLDYAIGQYDTYTPLELAQYVSTIANGGYRLKPQLVKEVREPDAKrgigavVQSV 572
Cdd:COG0768  379 QKTGIDLPGEASGLlPSPKRWYpGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGE------VVKE 452

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 573 QPEVLNKIdMKSEYIKEVQAGFRRVMTK--GTAASqFASASYQPAGKTGTAQSFYDGPDKSKTGtaTYNTTLVAYAPADN 650
Cdd:COG0768  453 EPEVLRRV-ISPETAETVREGMEGVVNEpgGTARR-AAIPGYRVAGKTGTAQVVDIGNGGYYKG--RHIASFVGFAPADN 528

                        650       660       670
                 ....*....|....*....|....*....|....*....
gi 516292863 651 PEIAISVVVPWA-YIDYSAkyTITNEIGREVMDKYFELK 688
Cdd:COG0768  529 PRYAVAVVVENPgGGAYGG--TVAAPVFREIMEAYLRLL 565
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 21-685 3.48e-104

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 330.25  E-value: 3.48e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863   21 RLNILFLAAFVIFTWIIVELGIKQIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKsttqe 100
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEK----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  101 qrlkiAKKLSDMIKvdtkkvterdkkdywiltrpkEAKKLISskerqqvedkkISDDDLyqlqlKRITDKqlneltdkdm 180
Cdd:TIGR03423  77 -----VDDLDATLD---------------------RLAKLLD-----------LDPEDI-----ARFLKE---------- 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  181 qilaIKRQmdSGYAltPQYIKnEDVSAKEMAVVSEHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEglpsNLLDH 260
Cdd:TIGR03423 105 ----LKRS--RRFE--PIPLK-SDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGYVGEINE----EDLER 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  261 YLSLGYSRNDRVGKSYLEYQYESLLQGQK--AKVEniTDSNGNVTGTKTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNlk 338
Cdd:TIGR03423 172 LEPANYAGGDYIGKSGIEKYYEDELRGKPgyREVE--VNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAAEKALGGR-- 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  339 sakarpstqlldRAFVVMMDPRNGEVLSMA----------GKQIKQENgkYKI----DDYAL--GTMTSSYAMGSAVKGA 402
Cdd:TIGR03423 248 ------------RGAVVVMDPRTGEILAMVstpsfdpnlfVDGISSKD--YKAllndPDRPLlnRAIQGVYPPGSTFKPV 313

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  403 TVLTGLQTGAINLNTVFQDePLYIgQDKNGK----KSWTTlGPVNIQRALEQSSNVFMFKTAIALGkgeykphqalpidt 478
Cdd:TIGR03423 314 VALAALEEGVITPETRIYC-PGYF-QLGGRRfrcwKRGGH-GRVDLRKAIEESCDVYFYQLALRLG-------------- 376

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  479 taFDTFRNYFSQFGLGVKTGIDLPNEMTG----------YKGTDRLTGFLLDYAIGQ-YDTYTPLELAQYVSTIANGGYR 547
Cdd:TIGR03423 377 --IDKIAEYAKRFGFGQKTGIDLPGEKSGlvpsrewkrkRFGQPWYPGDTLNVSIGQgYVLVTPLQLAVATAALANGGKL 454

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  548 LKPQLVKEVREPDakrgiGAVVQSVQPEVLNKIDMKSEYIKEVQAGFRRVMTK--GTAASQFASASYQPAGKTGTAQSFy 625
Cdd:TIGR03423 455 YKPHLVKSIEDPD-----GGVVRRTEPEVLRPLPISPENLDVVREGMRDVVNGpgGTARRARLGLPYKMAGKTGTAQVV- 528

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516292863  626 dgpdkSKTGTATYNTT-----------LVAYAPADNPEIAISVVV------PWAyidySAKytitneIGREVMDKYF 685
Cdd:TIGR03423 529 -----SLKQGEKYDAEqiperlrdhalFVAFAPYDNPKIAVAVIVehggggSSA----AAP------IARKIMDAYL 590
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 352-682 2.87e-82

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 263.12  E-value: 2.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  352 AFVVMMDPRNGEVLSMAGKQIKQENGKYkiDDYALGTMTSSYAMGSAVKGATVLTGLQTGAINLNTVFQDEPLYIGQDKN 431
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI--GPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGKQQGGKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  432 gKKSWTT--LGPVNIQRALEQSSNVFMFKTAIALGKgeykphqalpidttafDTFRNYFSQFGLGVKTGIDLPNEMTGYK 509
Cdd:pfam00905  79 -IGDWNQdqVGIGTLRQALEYSSNWYMQKLAQKLGA----------------DKLRSYLKKFGYGNKTGIGLPGENAGYL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  510 GTDRLTGFLLDYAIGqyDTYTPLELAQYVSTIANGGYRLKPQLVKevrepdakrgigAVVQSVQPEVLNKIDMKSEYIKE 589
Cdd:pfam00905 142 TPYWLEGATASFGIG--LTITPLQQAQAYAAIANGGKLVPPHLVK------------SIEDKVDPKVLNKLPISKSTAEK 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  590 VQAGFRRVMTKGTAASQFASASYQPAGKTGTAQSFydGPDKSKTGTATYNTTLVAYAPADNPEIAISVVVPWAYIDYSAK 669
Cdd:pfam00905 208 VKDMLRLVVNDGTGTGTAAVPGYKVAGKTGTAQVA--GPKGGGYYDGAQIGWFVGYAPADNPKYAFAVLIDDPKRYYGGK 285

                         330
                  ....*....|...
gi 516292863  670 ytITNEIGREVMD 682
Cdd:pfam00905 286 --VAAPIFKDILE 296
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 29-659 3.76e-41

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 159.55  E-value: 3.76e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  29 AFVIFTWIIVELGIK-------QIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIvtnkALNAITYtrsksttqeq 101
Cdd:PRK10795  22 ALVAFLGILLLTGVLianlynlQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL----ALNRTIY---------- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 102 RLKIAKKlsdmiKVDTKKVTERDkkdywiltrpkeakklisskerqqvedkkisdddlyqlqLKRITDkqlneLTDKDMQ 181
Cdd:PRK10795  88 QLEMMPE-----KVDNLQQTLDA---------------------------------------LRSVVD-----LTDDDIA 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 182 ILAIKRQMDSGYALTPQYIKNEDVSAKEMAVvseHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHY 261
Cdd:PRK10795 119 AFRKERARSRRFTSIPVKTNLTEVQVARFAV---NQYRFPGVEVKGYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEG 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 262 LSLGYSRNDRVGKSYLEYQYESLLQGQKAKVENITDSNGNVTGTKTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNlksak 341
Cdd:PRK10795 196 KLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQLHEQPPQAGHDIYLTLDLKLQQYIETLLAGS----- 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 342 arpstqlldRAFVVMMDPRNGEVLSMA------------GKQIKQENGKYKIDDYALGTMTSS--YAMGSAVKGATVLTG 407
Cdd:PRK10795 271 ---------RAAVVVTDPRTGGILALVstpsydpnlfvdGISSKDYSGLLNDPNRPLINRATQgvYPPASTVKPYVAVSA 341

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 408 LQTGAINLNTVFQDEPLYI--GQDKNGK--KSWTTlGPVNIQRALEQSSNVFMFKTAIALGkgeykphqalpidttaFDT 483
Cdd:PRK10795 342 LSAGVITRNTSLFDPGWWQlpGSEKRYRdwKKWGH-GRLNVTKSLEESADTFFYQVAYDMG----------------IDR 404

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 484 FRNYFSQFGLGVKTGIDLPNEMTGYKGTDR----------LTGFLLDYAIGQ-YDTYTPLELAQYVSTIANGGYRLKPQL 552
Cdd:PRK10795 405 LSEWMGKFGYGHYTGIDLAEERSGNMPTREwkqkrfkkpwYQGDTIPVGIGQgYWTATPIQMSKALMTLINDGIVKVPHL 484

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 553 VKEVREPdakrgiGAVVQSVQPEVLNKIDMKSEYIKEVQAGFRRVMTK--GTAASQFASASYQPAGKTGTAQSFydgpdk 630
Cdd:PRK10795 485 LMSTAED------GKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRpnGTAHKYFASAPYKIAAKSGTAQVF------ 552

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 516292863 631 SKTGTATYNTT-----------LVAYAPADNPEIAISVVV 659
Cdd:PRK10795 553 GLKANETYNAHkiaerlrdhklMTAFAPYNNPQVAVAIIL 592
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 67-305 7.76e-37

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 135.91  E-value: 7.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863   67 VPRGKIYDRNFNAIVTNKALNAITYTRS---KSTTQEQRLKIAKKLSDMIKVDTKKVTERdkkdywiltrpkeakkliss 143
Cdd:pfam03717   4 APRGEIYDRNGVVLATNKPVYSLTITPSklkKADALKTALKLAKLLSNYEDLDDEDLTER-------------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  144 kerqqvedkkisdddlyqlqlkritdkqlneltdkdmqilaiKRQMDSGYALTPQYIKnEDVSAKEMAVVSEHLDELPGV 223
Cdd:pfam03717  64 ------------------------------------------FLKMNSYKSYYPVVIK-KNLSEEEVARIEENLLELPGV 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  224 DVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNlldhYLSLGYSRNDRVGKSYLEYQYESLLQGQKAKVENITDSNGNVT 303
Cdd:pfam03717 101 SIETDPVRYYPYGELAAHLLGYVGEITEEELEK----YLDKGYSRGDLVGKSGLEKQYESVLRGKDGVRQVEVDALGRVI 176


                  ..
gi 516292863  304 GT 305
Cdd:pfam03717 177 RE 178
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 320-626 1.56e-28

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 121.57  E-value: 1.56e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 320 TIDIDLQKEVEKIIEKNLKSAKARPStqlldRAFVVMMDPRNGEVLSMAGkqikqeNGKYKID--DYALGTMTSsyaMGS 397
Cdd:COG0744  300 TLDPKLQKAAEKAVKNVLPEGKPGGL-----QAALVVVDPKTGEVLAMVG------GRDYGKSqfNRATQAKRQ---PGS 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 398 AVKGATVLTGLQTGaINLNTVFQDEPLYIGQD----KN-GKKSWttlGPVNIQRALEQSSNVFMFKTAIALGkgeykphq 472
Cdd:COG0744  366 TFKPFVYAAALEQG-YTPATTVDDEPVTFPGGgwspKNyDGRYR---GPVTLREALANSLNTPAVRLAQEVG-------- 433

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 473 alpidttaFDTFRNYFSQFGLGVKTGIDLPNemtgykgtdrltgflldyAIGQYDTyTPLELAQYVSTIANGGYRLKPQL 552
Cdd:COG0744  434 --------LDKVVDTARRLGITSPLDPNPSL------------------ALGTSEV-SPLEMASAYATFANGGVYVEPHA 486

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516292863 553 VKEVREPDakrgiGAVVQSVQPEVLNKIDMKSEYIkeVQAGFRRVMTKGTAASqfASASYQP-AGKTGTAQSFYD 626
Cdd:COG0744  487 ITKVTDAD-----GKVLYEAKPKCEQVISPEVAYL--MTDMLQDVVTSGTGRA--ARLPGRPvAGKTGTTNDNRD 552
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 219-659 1.09e-20

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 96.43  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 219 ELPGVDVTSDWEREYPYknllrsvlGSVSSsneglpsnlldHYLslGYSRNDRVGKSYLEYQYESLLQGQKAKVENITDS 298
Cdd:PRK15105 154 KLPGIHLREESRRYYPS--------GEVTA-----------HLI--GFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDR 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 299 NGNVTGTKTVSEGKAGKDLVLTIDIDLQKEVEKIIEKNLKSAKARPSTqlldrafVVMMDPRNGEVLSMAGKQIKQEN-- 376
Cdd:PRK15105 213 YGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGS-------AVLVDVNTGEVLAMANSPSYNPNnl 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 377 -GKYKiDDYALGTMTSSYAMGSAVKGATVLTGLQTGAINLNTVFQDEPLYIgqdkNGK--KSWTTLGPVNIQRALEQSSN 453
Cdd:PRK15105 286 sGTPK-DAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNTVPYRI----NGHeiKDVARYSELTLTGVLQKSSN 360

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 454 VFMFKTAIALgkgeykPHQALpIDTtafdtfrnyFSQFGLGVKTGIDLPNEMTG-------YKGTDRLTgFLLDYAIgqy 526
Cdd:PRK15105 361 VGVSKLALAM------PSSAL-VDT---------YSRFGLGKATNLGLVGERSGlypqkqrWSDIERAT-FSFGYGL--- 420

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 527 dTYTPLELAQYVSTIANGG-YRlkPQLVKEVREPDAKrgigavvQSVQPEVLnkidmkseyIKEVQAGFRRVMTKGTAAS 605
Cdd:PRK15105 421 -MVTPLQLARVYATIGSYGiYR--PLSITKVDPPVPG-------ERVFPESI---------VRTVVHMMESVALPGGGGV 481

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516292863 606 QFASASYQPAGKTGTAQSFydGPDksktgtATYNTTLVAY----APADNPEIAISVVV 659
Cdd:PRK15105 482 KAAIKGYRIAIKTGTAKKV--GPD------GRYINKYIAYtagvAPASQPRFALVVVI 531
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 269-626 1.04e-17

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 86.93  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  269 NDRVGKSyLEYQYESLLQGQKAKVENITDSNGNVTGTKtvsegkagkdLVLTIDIDLQKEVEKIIEKNLKSAKARPSTQL 348
Cdd:TIGR02074 187 YLQTKKS-EQYKAPYFVDYVIQELEEEYGEELYTGGLK----------IYTTLDLDAQKAAEKVLNTGLRVAGRRDGDDL 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  349 ldRAFVVMMDPRNGEVLSMAGKQIKQENGKykidDYALGTMTSSyamGSAVKGATVLTGLQTGaINLNTVFQDEPlyigQ 428
Cdd:TIGR02074 256 --QAALVAIDPDTGAVRALVGGRDYGKSQF----NRATQAKRQP---GSTFKPFVYAAALEKG-LTPATIVNDEP----I 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  429 DKNGKKSWTT-------LGPVNIQRALEQSSNVFMFKTAIALGkgeykphqalpiDTTAFDTFRnyfsqfglgvKTGIDL 501
Cdd:TIGR02074 322 TYNGNGPWSPknygggyRGNVTLRQALAQSRNIPAVRLLQEVG------------LDKVVALAK----------RFGITS 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863  502 PNEMTgykgtdrltgflLDYAIGQYDTyTPLELAQYVSTIANGGYRLKPQLVKEVREPDakrgiGAVVQSVQPEVLNKID 581
Cdd:TIGR02074 380 PLDPV------------LSLALGTVEV-SPLEMASAYAVFANGGKYVEPHGIRKIVDRD-----GKVIYENKPKTTQVIS 441

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 516292863  582 MKSEYIkeVQAGFRRVMTKGTAASQfASASYQPAGKTGTAQSFYD 626
Cdd:TIGR02074 442 PATAYI--MTDMLKGVVESGTGRSA-RLPGRPVAGKTGTTQNWRD 483
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
352-626 4.46e-12

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 69.42  E-value: 4.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 352 AFVVMmDPRNGEVLSMAGkqikqenGkYkidDYALgtmtSSY-----AM---GSAVKGATVLTGLQTGaINLNTVFQDEP 423
Cdd:COG5009  424 ALVAL-DPHTGAVLALVG-------G-F---DFEQ----SKFnratqAKrqpGSSFKPFVYAAALDNG-YTPATIINDAP 486

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 424 LYIgQDKNGKKSW-------TTLGPVNIQRALEQSSNVFMFKTAialgkgeykphQALPIDTTAfdtfrNYFSQFGLGVK 496
Cdd:COG5009  487 IVF-DDGGGGGVWrpknysgKFYGPTTLREALEKSRNLVTVRLL-----------QDVGIDYVI-----DYAERFGIYSK 549

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 497 TGIDLPNemtgykgtdrltgflldyAIGQYDTyTPLELAQYVSTIANGGYRLKPQLVKEVR--------EPDAKRGIGAV 568
Cdd:COG5009  550 LPPNLSL------------------ALGSGEV-TPLEMARAYAVFANGGYRVEPYLIDRIEdrngkviyRADPARACEDC 610

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516292863 569 VQSVQPEVLNKIDMKSEYIKEVQAGF------RRVMTKGTAASqfASASYQP-AGKTGTAQSFYD 626
Cdd:COG5009  611 DAAEWDGAEPRLPDPAEQVIDPRTAYqmtsmlRGVVQRGTGRR--ARALGRDiAGKTGTTNDSKD 673
mrcB PRK09506
bifunctional glycosyl transferase/transpeptidase; Reviewed
 320-626 1.87e-08

bifunctional glycosyl transferase/transpeptidase; Reviewed


Pssm-ID: 236544 [Multi-domain]  Cd Length: 830  Bit Score: 57.86  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 320 TIDIDLQKEVEKIIEKNLKSAKARPSTQLLDRAFVVMmDPRNGEVLSMAGKQIKQENGKYKiddyalgTMTSSYAMGSAV 399
Cdd:PRK09506 439 TLDPVSQDAAEKAVEEGIPALKKQRKLSDLETAMVVV-DRFSGEVRAMVGGSEPQFAGYNR-------AMQARRSIGSLA 510

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 400 KGATVLTGL-QTGAINLNTVFQDEPLYIGQdKNGKkSWTtlgPVNIQR----------ALEQSSNVFMFKTAIALGkgey 468
Cdd:PRK09506 511 KPATYLTALsQPDKYRLNTWIADAPISLRQ-PNGQ-VWS---PQNDDRrfsgrvmlvdALTRSMNVPTVNLGMALG---- 581

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 469 kphqalpidttaFDTFRNYFSQFGLGVKTGIDLPNEMTGykgtdrltgflldyAIGqydtYTPLELAQYVSTIANGGYRL 548
Cdd:PRK09506 582 ------------LPAVTDTWIKLGVPKDQLNPVPAMLLG--------------ALN----LTPIEVAQAFQTIASGGNRA 631

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516292863 549 KPQLVKEVREPDakrgiGAVVQSVQPEVLNKIDMKSEYIkeVQAGFRRVMTKGTAASQFAS-ASYQPAGKTGTAQSFYD 626
Cdd:PRK09506 632 PLSALRSVIAED-----GKVLYQSFPQAERAVPAQAAYL--TLYTMQQVVQRGTGRQLGAKyPNLHLAGKTGTTNDLVD 703
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 313-626 6.41e-08

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 56.01  E-value: 6.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 313 AGKDLVLTIDIDLQKEVEKIIEKNLKSAKARPSTQLLDRAfVVMMDPRNGEVLSMAGKQIKQENGKYKiddyALGTMTSs 392
Cdd:PRK14850 378 SGTKIFTTLDYISQNAAEQAVKIGIPILKRKKRLKDLEVA-MVIIDRFSGEVRALIGSSKPEFNGYNR----ALKARRS- 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 393 yaMGSAVKGATVLTGL-QTGAINLNTVFQDEPLYIGQDkNGKkSWTT-------LGPVNIQRALEQSSNVFMFKTAIALG 464
Cdd:PRK14850 452 --IGSLSKPITYLTALsQPEKYHLNTWISDTPISIKLD-NGQ-YWTPknnnfsfSGKVMLIDALIHSINIPTVHLSINLG 527

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 465 kgeykphqalpidttaFDTFRNYFSQFGLGVKTGIDLPNEMTGykgtdrltgflldyAIgqydTYTPLELAQYVSTIANG 544
Cdd:PRK14850 528 ----------------LKKLVDSWILLGISSNYITPLPSISLG--------------AI----NLTPMEVAQVFQIIGSG 573

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516292863 545 GYRLKPQLVKEVREPDAKrgigaVVQSVQPEVLNKIDMKSEYIkeVQAGFRRVMTKGTAAS---QFASASYqpAGKTGTA 621
Cdd:PRK14850 574 GYKSSLSSIRSIISDDNK-----VLYQNFPQSKHVESSQASYL--TLYAMQQVVKSGTAKSlgtIFKEFSL--AGKTGTT 644


                 ....*
gi 516292863 622 QSFYD 626
Cdd:PRK14850 645 NNLVD 649
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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