|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
9-376 |
7.15e-88 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 271.05 E-value: 7.15e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 9 LPLQSFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFW 88
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 89 ISTAD-SLFDLILGGFFLGIGGAVFSIGVTSLPKYYPKEK-HGFVNGIYGAGNVGTAITTFAAPVVAKTA-------GWE 159
Cdd:cd17341 81 LALAVsSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKiGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 160 NTVRMYIVLVAVFALLNFILGDRKETKV--TVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDP 237
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGKasALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 238 VDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVA-----VCAGLGNGII 312
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALfvalgLGAGAGNGSV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521287369 313 FKLVPLYFSNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVW 376
Cdd:cd17341 321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-378 |
7.02e-79 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 248.26 E-value: 7.02e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 3 NRQKIQLPLQSFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLL 82
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 83 LFPIFWISTADSLFDLILGGFFL-GIGGAVFSIGVTSLPKYYPKEKHGFVNGIY-GAGNVGTAITTFAAPVVAKTAGWEN 160
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLgIGGGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 161 TVRMYIVLVAVFALLNFILGDRKETKVTVSVTE---QMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDP 237
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAslrDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 238 VDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSP-SLGLYGFGVLTVAVCAGLGNGIIFKLV 316
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521287369 317 PLYF-SNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWMY 378
Cdd:COG2223 321 PDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
14-339 |
3.85e-47 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 164.40 E-value: 3.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 14 FSLVAGFMVWVLISSLMPH-IKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTA 92
Cdd:TIGR00886 8 FGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 93 DSLFDLILGGFFLG-IGGAVFSIGVTSLPKYYPKEKHGFVNGIY-GAGNVGTAITTFAAPVVAKTA------------GW 158
Cdd:TIGR00886 88 VQSYSVLLLIRLFIgIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIGSLifgggqpahlawGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 159 ENTVRMYIVLVAVFALLNFILGDR---KETKVTVSVTEQMKaVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGL 235
Cdd:TIGR00886 168 AFVIVPAGILLLPALLIFFVGADTppgKPATGKLSFKEALK-VFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 236 DPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLS--GILLAFSPSLGLYGFGVLTVAVC--AGLGNGI 311
Cdd:TIGR00886 247 SKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGafLVVLGLVSDGSLAAFIVLFVALFffAGAGNGS 326
|
330 340
....*....|....*....|....*...
gi 521287369 312 IFKLVPLYFSNQAGIVNGIVSAMGGLGG 339
Cdd:TIGR00886 327 TFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-377 |
9.53e-30 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 118.44 E-value: 9.53e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 21 MVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLIL 100
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 101 GGFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWENTVRMYIVLVAVFALL-NFI 178
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAmGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLwLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 179 LGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHfGLDPVDSGLRTAGFIAVATFLRPVG 258
Cdd:COG2807 192 LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 259 GWLADKFNPLKLLMYVFAGCTLSGIL-LAFSPSLGLYGFgvltvAVCAGLGNGIIFKLVPLYFSN------QAGIVNGIV 331
Cdd:COG2807 271 PLLADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPWLW-----AVLLGLGQGGLFPLALTLIGLrartpaEAAALSGMA 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 521287369 332 SAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWM 377
Cdd:COG2807 346 QSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-377 |
1.23e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.19 E-value: 1.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 3 NRQKIQLPLQSFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLL 82
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 83 LFPIFWISTADSLFDLILGGFFLGIGGAVFSIGVTSL-PKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWEN 160
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLiAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 161 TVRMYIVLVAVFALLNFilgdrketkvtvsvteqmkavyrnqtlWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDS 240
Cdd:COG2271 166 AFLILGLPGLLLALLRF---------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 241 GLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYV--FAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPL 318
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 319 YFS-NQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGhYAIGFMALSEAALASFVIVVWM 377
Cdd:COG2271 299 LFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-339 |
7.95e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.90 E-value: 7.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 4 RQKIQLPLQSFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLL 83
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 84 FPIFWISTADSLFDLILGGFFL-GIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWENT 161
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 162 VRMYIVLVAVFALLNFILGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSG 241
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 242 LRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFS 321
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330
....*....|....*....
gi 521287369 322 -NQAGIVNGIVSAMGGLGG 339
Cdd:COG2814 327 pEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-343 |
1.96e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 1.96e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 15 SLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADS 94
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 95 LFDLILGGFFL-GIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWENTVRMYIVLVAVF 172
Cdd:pfam07690 85 LWLLLVLRVLQgLGAGALFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAILSLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 173 ALLNFILGDRKETK-------VTVSVTEQMKAVYRNQTLWFLSLFyFITFGSFVAFTIYLPnFLVNHFGLDPVDSGLRTA 245
Cdd:pfam07690 165 AVLLLLPRPPPESKrpkpaeeARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 246 GFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFgVLTVAVCAGLGNGIIFKLVPLYFS---- 321
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLW-LLLALLLLGFGFGLVFPALNALVSdlap 321
|
330 340
....*....|....*....|...
gi 521287369 322 -NQAGIVNGIVSAMGGLGGFFPP 343
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-376 |
2.78e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.54 E-value: 2.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 21 MVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLfdlil 100
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY----- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 101 ggFFLGIGGAVFSIGVTSL--------PKYYPKEKHGFVNGIYGAGNVGTAITTFAAPVVAKtAGWENTVRMYIVLVAVF 172
Cdd:COG0738 97 --PLLLLALFLLGLGLGLLdvaanpyvAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIL-LGLSLSWHLPYLILAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 173 ALLNFIL-------GDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTA 245
Cdd:COG0738 174 LLLLALLflrsklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 246 GFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFSNQAG 325
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTA 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 521287369 326 IVNGIVSAMGGLGGFFPPLILSSVFQATG-HYAIGFMALSEAALASFVIVVW 376
Cdd:COG0738 334 AAVSAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
26-375 |
3.63e-20 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 90.71 E-value: 3.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 26 ISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFV---LLLFPIFWISTADSLFdlILGG 102
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLlwsLFTALTGFATSLTSLY--VLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 103 FFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWENtvrMYIVlvavFALLNFILGd 181
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGApLGAAIGPPLSGWLLLLFGWRW---AFII----EGLLGLLLA- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 182 rketkvtvsvteqMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWL 261
Cdd:cd17319 172 -------------VLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 262 ADKFNPLKLLMYVFAGCTLSGILLAFSPSLG--LYGFGVLTVA-VCAGLGNGIIFKLVPLYFS-NQAGIVNGIVSAMGGL 337
Cdd:cd17319 239 SDRLLRGARRLVIIIGLLLAAVGLLLAYLTTspVVAVILLSLAgFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNL 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 521287369 338 GGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVV 375
Cdd:cd17319 319 GGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-375 |
2.24e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.94 E-value: 2.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 13 SFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTA 92
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 93 DSLFDLILGGFFLGIGGAVF-SIGVTSLPKYYPKEKHGFVNGIY-GAGNVGTAITTFAAPVVA--KTAGWENTVRMYIVL 168
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIdPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 169 VAVFALLNFIL--------GDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDS 240
Cdd:cd06174 162 ALLAAILLLLVvpdppesaRAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 241 GLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYV-FAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLY 319
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 320 FS-NQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVV 375
Cdd:cd06174 322 FPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-378 |
8.11e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.16 E-value: 8.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 13 SFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTA 92
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 93 DSLFDLILGGFFLGIGGAVFSIGVTSL-PKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWentvRMYIVLVA 170
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALiADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGY----RAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 171 VFALLNFILG----------DRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDS 240
Cdd:cd17325 158 ALALLALVLAllllpeprppPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 241 GLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLygfgVLTVAVCAGLGNGIIFKLVPLYF 320
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL----LLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521287369 321 SNQA-----GIVNGIVSAMGGLGGFFPPLILSSVFQATGhYAIGFMALSEAALASFVIVVWMY 378
Cdd:cd17325 314 ADIVppegrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
16-379 |
7.52e-16 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 78.77 E-value: 7.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 16 LVAGFMVWVLISSLMPHI-KQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWI----- 89
Cdd:PRK15034 43 LLLAFCVWMLFSAVTVNLnKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCVWLgiavq 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 90 STADSLFDLILGGFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGA-GNVGTAITTFAAPVV---------------- 152
Cdd:PRK15034 123 NPNTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINGGlGNLGVSVMQLVAPLVifvpvfaflgvngvpq 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 153 --AKTAGWENTVRMYIVLVAVFALLNFI-LGDRKETKvtVSVTEQMKAVYRNQtLWFLSLFYFITFGSFVAFTIYLPNFL 229
Cdd:PRK15034 203 adGSVMSLANAAWIWVPLLAIATIAAWSgMNDIASSR--ASIADQLPVLQRLH-LWLLSLLYLATFGSFIGFSAGFAMLA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 230 VNHFgldPVDSGLRTAGFIA-VATFLRPVGGWLADKFNPLKLLMYVFAGCTL-SGILLAFSPSLGLYGFGVLTVA----- 302
Cdd:PRK15034 280 KTQF---PDVNILRLAFFGPfIGAIARSVGGAISDKFGGVRVTLINFIFMAIfSALLFLTLPGTGSGNFIAFYAVfmglf 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 303 VCAGLGNG-------IIFKLVPLYFSNQAGIVN---------------GIVSAMGGLGGFFPPLILSSVFQATGHyAIGF 360
Cdd:PRK15034 357 LTAGLGSGstfqmiaVIFRQITIYRVKMKGGSDeqaqreavtetaaalGFISAIGAVGGFFIPQAFGMSLNMTGS-PVGA 435
|
410
....*....|....*....
gi 521287369 361 MALSEAALASFVIVVWMYF 379
Cdd:PRK15034 436 MKVFLIFYIVCVLLTWLVY 454
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
26-377 |
6.08e-13 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 69.53 E-value: 6.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 26 ISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIfWISTADSLFDLILGGFFL 105
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGI-LLRSLGGIALLFLGTALA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 106 GIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTA--GWENTVRMYIVLVAVFALLNFILGDR 182
Cdd:cd17339 97 GAGIAVGNVLLPSLIKRDFPRRVGLMTGLYTTSmNLGAALASGLSVPLAQALggGWRGALAIWALPALLALLIWLPQLRR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 183 KETKVTVSVTEQMKAVYRNQTLWFLSLFYFITfgSFVAFTI--YLPNFLVNHfGLDPVDSGLRTAGF---IAVATFLRPv 257
Cdd:cd17339 177 RKRAAAAAAPLTKISVWRSPLAWQVTLFMGLQ--SLLFYTLmaWLPTILIDA-GLSAATAGWLLSLFqlvGIPASLLVP- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 258 ggWLADKFNPLKLLMYVFAGCTLSGIL-LAFSPSlglygFGVLTVAVCAGLGNGIIFKLVPLYFS------NQAGIVNGI 330
Cdd:cd17339 253 --ILATRLKNQRPIVVLLAVLFIIGVLgLLFAPT-----ALALLWAVLLGLGGGAAFSLALTLISlrssdpAEAAALSGM 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 521287369 331 VSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWM 377
Cdd:cd17339 326 AQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLGA 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-373 |
1.14e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 68.73 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 25 LISSLMPHIKQDIALTDSEISL---VTAIPVILGSLlriPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILG 101
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLlvsAYALGYALGAL---LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 102 GFFLGIGGAVF-SIGVTSLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWentvRMYIVLVAVFALLNFIL 179
Cdd:cd17324 94 RALAGLAHGGFwAIAAAYAADLVPPEKRGRAIGLVFSGLtLGLVLGRPLGGLLGQLLGW----RAAFLAIAVLALLAALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 180 ------GDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATF 253
Cdd:cd17324 170 lwrllpSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 254 LRPVGGWLADKFnPLKLLMYVFAGCTLSGILLAFspsLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFSNQA----GIVNG 329
Cdd:cd17324 250 GSPLAGRLADRG-GRRALLIALLLLAAALLLLTL---LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLApearGLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 521287369 330 IVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVI 373
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-374 |
2.97e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 13 SFSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISfvLLLFPIF--WIS 90
Cdd:cd17474 5 FFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG--LLLFGIGglLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 91 TADSLFDLILGGFFLGIGGAVF-SIGVTSLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAkTAGWENTVRMYIVL 168
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLgPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 169 VAVFALLNFILGDRKETKVTVSVTE---QMKAVYRNQTLW---FLSLFYFITFGSFVAftiYLPNFLVNHFGLDPVDSGL 242
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSSATklrDLKKALRGRGLLtflVSAFLYFFLYFAFLT---YLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 243 RTAGF-IAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLygfgVLTVAVCAGLGNGIIFKLVPLYFS 321
Cdd:cd17474 239 LFAGWsVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLAL----LLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 521287369 322 NQA-----GIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIgFMALSEAALASFVIV 374
Cdd:cd17474 315 ELApeeerGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
27-376 |
3.42e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.21 E-value: 3.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 27 SSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLL---LFPIFWISTADSLFDLILGGF 103
Cdd:cd17355 23 GVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLaagLVLLALATSLWQLYLLWGLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 104 FLGIGGAVFSIGVTSLPKYYPkEKHGFVNGIYGAGNvGTAITTFAaPVVA---KTAGWENTVRMY--IVLVAVFALLNFI 178
Cdd:cd17355 103 GGGAGTLAAVAFATVAAWWFE-RRRGLALGILTAGG-GLGSLVFL-PLGAaliEAFGWRTALLVLalLALLVLVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 179 LGDRKETKVTV-------SVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHfGLDPVDSGLRTAGFIAVA 251
Cdd:cd17355 180 RRRPADLALRAyddaspaSPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 252 TFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFS--PSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFSNQAGIVNG 329
Cdd:cd17355 259 IVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLpfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 521287369 330 IVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVW 376
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
17-354 |
5.12e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 5.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 17 VAGFMVWVLISSLMPHIKQDIA-LTDSEISLVTAIPVILGSLLRIPLGYYTNRFGAR------------ITFMISFVLLL 83
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLgLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwiligaIPLALSFVLLF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 84 FPIFWISTADSLFdLILGGFFLGIGGAVFSIGVTSL-----PKYypkEKHGFVNGI-YGAGNVGTAITTFAAPVVAKTAG 157
Cdd:COG2211 100 TAPDLSPTGKLIY-ALVTYLLLGLAYTLVNIPYSALgaeltPDY---EERTRLSSWrFAFAGLGGLLASVLPPPLVAAFG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 158 wENTVRMYIVLVAVFALLNFILG---------DRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNF 228
Cdd:COG2211 176 -GDAALGYRLTALIFAVLGLLAFlltffgtkeRPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 229 LVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFgvLTVAVCAGLG 308
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLL--LVLAALAGIG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 521287369 309 NGIIFKLVPLYFS------------NQAGIVNGIVSAMGGLGGFFPPLILSSVFQATG 354
Cdd:COG2211 333 LGAILVLPWAMLAdvvdydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
14-374 |
2.87e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.49 E-value: 2.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 14 FSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTAD 93
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 94 SLFDLILGGFFLGIGGAVF-SIGVTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWENTVRMYIVLVAV 171
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVqPGGGRAIMRWFPPRERGLAMGIRQTGvPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 172 FALLNFIL-----GDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSG-LRTA 245
Cdd:cd17475 163 AAVLFWLFyreppAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGaLLAV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 246 GFIAvATFLRPVGGWLADKFNP------LKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLY 319
Cdd:cd17475 243 AQLG-GALGRIGLGRVSDRVFGgrrrpvLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 521287369 320 F-SNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIV 374
Cdd:cd17475 322 AgPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
25-338 |
4.61e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 60.65 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 25 LISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILGGFF 104
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 105 LGIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGA-GNVGTAIT-TFAAPVVAKTAGWENTVRMYIVLVAVFALLNFILGDR 182
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVgGNLGFALGpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 183 KETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFV--AFTIYLPnFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGW 260
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVlsSLTTFLP-FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 261 LADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLT-VAVCAGLGNGIIF--KLVPLYFSNQAGIVNGIVSAMGGL 337
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAgFLLFASFPVTVVLaqELLPGNVGLASGLMMGLSFGLGGI 332
|
.
gi 521287369 338 G 338
Cdd:cd17478 333 G 333
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-375 |
6.38e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 6.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 20 FMVWVLISSLMPHIKQDI--ALTDSEISLVTAIPVI---LGSLLripLGYYTNRFGARITFMISFVLLLFPIFWISTADS 94
Cdd:cd17316 12 AYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLgrpIGALL---FGYLGDRIGRKKALILTLLLFGLATLLIGLLPT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 95 LFDLILG-GFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIY-GAGNVGTAITTFAAPVVAKTAGWENTVRMYIVLVAVF 172
Cdd:cd17316 89 PILLLVLrFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 173 ALLNFILgdRKetkvtvsvteqmkavyrnqTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVAT 252
Cdd:cd17316 169 ALLALLL--RR-------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 253 FLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLY--GFGVLTVAVCAGLGNGIIFKLVPLYF-SNQAGIVNG 329
Cdd:cd17316 228 VGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTllLLLLFILSFFVGGVWGALYAYLAELFpTEVRATGVG 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 521287369 330 IVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVV 375
Cdd:cd17316 308 LSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
199-377 |
2.48e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.45 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 199 YRNQTLWFLSLFYFITFGSFVAFTIYLPnFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGC 278
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 279 TLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFS-NQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGhYA 357
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WR 164
|
170 180
....*....|....*....|
gi 521287369 358 IGFMALSEAALASFVIVVWM 377
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL 184
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-354 |
5.06e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 57.39 E-value: 5.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 29 LMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILGGFFLGIG 108
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 109 GAVFSIGVTS-LPKYYPKEKHGFVNGIYGAG-NVGTAI-TTFAAPVVAKTAGWENTVRMYIVLVAVFALLNFILG----- 180
Cdd:TIGR00881 97 QGMGWPPCGRtVTKWFSRSERGTWVSFWNCShNVGGGLlPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLrdspq 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 181 ----------------DRKETKVTVSVTEQMKAVY--RNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGL 242
Cdd:TIGR00881 177 scglppaeempneepdGDAEKKEEELTKKQIFLQYvlLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 243 RTAGFIAVATFLRPVGGWLADKF---NPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVcAGLGNGIIF----KL 315
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFAL-GFLVYGPQMligvIA 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 521287369 316 VPLYFSNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATG 354
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-376 |
7.60e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.83 E-value: 7.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 14 FSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTAD 93
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 94 SLFDLILGGFFLGIGGAVFSIG-VTSLPKYYPKEKHGFVNGIYGagnVGTAITTFAAPVVAKTAGWENTVRMYIVLVAVF 172
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAaATLVADIIPPSRRGEGIGYYG---LATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 173 ALLNFILGDRKETKVTVSVTEQ-----MKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFgldPVDSGLRTAGF 247
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAeagtrAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 248 IAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLygfgVLTVAVCAGLGNGIIF--------KLVPly 319
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWM----LLLAAVLYGLGFGLLFpalqalavDLVP-- 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 320 fSNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGhYAIGFMALSEAALASFVIVVW 376
Cdd:cd17489 311 -PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
16-313 |
1.47e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.05 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 16 LVAGFMVWVLISSL---MPHIKQDIALTDSEISLVTAIpVILGSLLRIPL-GYYTNRFGARITFMISFVLLLFPIFWIST 91
Cdd:cd17503 2 LLGAFMAILDTTIVnvaLPTIMGDLGASLDTVQWVITS-YLLALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 92 ADSLFDLILGGFFLGIGGAV-FSIGVTSLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWEntvrmYIVLV 169
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLVIlLAPAIGPTLGGWLTDNLSWR-----WIFYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 170 AV-FALLNFILGDRKETKVtvsvteqmkavYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFI 248
Cdd:cd17503 156 NLpIGILALLLAPLLDLRL-----------FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGG 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521287369 249 AVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFsPSLGLYGFGVLTVAVCAGLGNGIIF 313
Cdd:cd17503 225 LASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF-LTPDTSLWLIILPLFIRGLGMGLVF 288
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
21-377 |
2.21e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 2.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 21 MVWVLISSLMPHIKQDIALTDSE-ISLVTAIP---VILGSLLripLGYYTNRFGARITFMISFVLLLFPIFWISTADSLF 96
Cdd:cd17473 13 MAGAAIAPALPAIAQHFVPNSELlVPLLLTLPalfIALFAPL---AGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 97 DLILGGFFLGIGGAVFSIGVTSLPKYY--PKEKHGFVNGIYGAGNVGTAITTFAAPVVAkTAGWENTVRMYIV--LVAVF 172
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYfeGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLalPVLIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 173 ALLnFILGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLrtagFIAVAT 252
Cdd:cd17473 169 VLL-FLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL----ALAIAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 253 FLRPVGG----WLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLygfgVLTVAVCAGLGNGIIF-----KLVPLYFSNQ 323
Cdd:cd17473 244 LAGAIGAllfgRLKRRLGKRRLLAIGFALMALGFLLLALASGLWV----VLLGAILAGLGFGLLLptlnsWAMSLVPPEL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 521287369 324 AGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWM 377
Cdd:cd17473 320 RGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
24-378 |
6.05e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.13 E-value: 6.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 24 VLISSLMPHIKQDIALTDSEISLVTAIPVI---LGSLLRIPLGyytNRFGARITFMISfvLLLFPIFWISTAdslFDLIL 100
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFgmaIGALLAGPLA---DRFGRKRVLLVS--VALFGLFTLLTA---FAQSV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 101 GGFFLGIGGAVFSIG------VTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWEntVRMYIVLVAVFA 173
Cdd:cd17365 88 LQLALLRFLTGLGLGaampnaITLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWR--SVFLLGGVPPLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 174 LLNFILGdrketkvtvsvteqmkavyrnqTLWfLSLFYFITFGSFVAFTIYLPNfLVNHFGLDPVDSGLRTAGFIAVATF 253
Cdd:cd17365 166 LLPLLRG----------------------TLL-LWVTFFMGLLLVYLLNSWLPK-LMVEAGYSLSQALTITLLLNIGGVI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 254 LRPVGGWLADKFNPLKLLM--YVFAGCTLSGILLAFSPSLGLYGFGVLTvAVCAGLGNGIIFKLVPLYFSNQA-GIVNGI 330
Cdd:cd17365 222 GSLLLGWLADRFGPKRVLAlfFALGAVSLALLGVSPASLVLLYVLVFLA-GACVNGAQVGLYALAARFYPTEVrATGVGW 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 521287369 331 VSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWMY 378
Cdd:cd17365 301 ALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
32-373 |
1.44e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 52.94 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 32 HIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILGGFFLGIGGA- 110
Cdd:cd17352 28 ELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLg 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 111 -VFSIGVTSLPKYYPKeKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWENTVRmyivLVAVFALLNFILGdrketkvt 188
Cdd:cd17352 108 lIYSPAIVIVGQYFEK-KRGLATGIAVAGSgVGTFVFPPLLRYLLDNYGWRGALL----ILGGLCLNLCVCG-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 189 vsvteQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHfGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPL 268
Cdd:cd17352 175 -----LLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESDAAFLLSIIGISDIVGRILLGLLADKPRIG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 269 KLLMYVFAgCTLSGILLAFSPSLGLYGfGVLTVAVCAGLGNGIIFKLVPLYFSNQAGIVN-----GIVSAMGGLGGFFPP 343
Cdd:cd17352 249 RLYLYIFT-LLILGLSLLAFPLATTYV-GLIVFSVLFGFCSGSYSSLTPVILADLVGLEKlsnayGLVLLFQGLAALVGP 326
|
330 340 350
....*....|....*....|....*....|
gi 521287369 344 LILSSVFQATGHYAIGFMALSEAALASFVI 373
Cdd:cd17352 327 PIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-377 |
1.46e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.95 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 16 LVAGFMVWVLISSL---MPHIKQDIALTDSEIS-LVTAIPVILGSLLrIPLGYYTNRFGARITFMISFVLLLFPIFWIST 91
Cdd:cd17321 2 LLAVFLAALDVTIVnvaLPTIARDLGASPSQLQwVVNAYLLAFAALL-LLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 92 ADSLFDLILGGFFLGIGGAVFSIGVTSLPK-YYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWentvRMYIVLV 169
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAaTFPGERRGRALGLWGAVVgIGAALGPLLGGLLLELFGW----RWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 170 AVFALLNFILGdrketkvtvsvteqmkavyRNQTLWFLSLFyfITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIA 249
Cdd:cd17321 157 VPIGLVALLLA-------------------RTFSGAVLAAF--LLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLAL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 250 VATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFgVLTVAVCAGLGNGIIFKLVPLYFSN-----QA 324
Cdd:cd17321 216 AMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWL-LLPGLVLLGLGLGLFATPLTNAALSsvpkeKA 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 325 GIVNGIVSAMGGLGGFFPPLILSSVF-------QATGHYAIGFMALSEAALASFVIVVWM 377
Cdd:cd17321 295 GAASGILNTARQLGGALGVALLGALLtaglsanLGDSGVAALLSAAAAAFAAGFHLAFLV 354
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
14-374 |
3.90e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.55 E-value: 3.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 14 FSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIpVILGSLL-RIPLGYYTNRFGARITFMISFVLLLFPIFWISTA 92
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSS-QNAGYLIgSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 93 DSLFDLILGGFFLGIGGAVF-SIGVTSLPKYYPKEKHGFVNGIYGAGNVGTAITTFAAPVVAKTAGWENTVRM-----YI 166
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILdTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLiigliYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 167 VLVAVFALLNFILGDRKETKVTVSVTEQ--MKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRT 244
Cdd:cd17333 162 LLAILILLTLFPELPSARNPQQSVGAFSasASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 245 AGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLglygFGVLTVAVCAGLGNGIIFKLVPLYFSNQA 324
Cdd:cd17333 242 SGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTL----VVGLVATALLGLFMAALFPTILSLGISNL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 521287369 325 GI----VNGIVSAMGGLGGFFPPLILSSVFQATG-HYAIGFMALSEAALASFVIV 374
Cdd:cd17333 318 PYakgkGTSVLLAAGSIGGAIIPFIMGFIAEAVGiQTAMLLITILYAIIFVLALL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
207-391 |
9.64e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 9.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 207 LSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLA 286
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 287 FSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFSNQA-GIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMAlse 365
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL--- 157
|
170 180
....*....|....*....|....*.
gi 521287369 366 AALASFVIVVWMYFQEVSKTSTKTKT 391
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPA 183
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
157-316 |
1.40e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 49.99 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 157 GWentvRMYIVLVAVFALLNFILgdRKETKVTVSVTEQMKAVYRNQTLW---------FLSLFYFITFGS--FVAFTIYL 225
Cdd:cd17367 173 GW----RIPFLLGGVLAVVVLWL--RRGLEETESFEAIAESNEASAGTLrelrrhpreLLLVVGLTAGGTlaFYTWTTYL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 226 PNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLS--GILLAFSPSLGLYG-FGVLTVA 302
Cdd:cd17367 247 QKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLAtvPLLSALDHTDSPYTaFALVLVG 326
|
170
....*....|....
gi 521287369 303 VCAGLGNGIIFKLV 316
Cdd:cd17367 327 LVFLSGYTSINAVV 340
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
26-360 |
2.76e-06 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 49.04 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 26 ISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILGGFFL 105
Cdd:PRK09705 28 VGPLLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 106 GIGGAVFSIGVTSLPKYYPKEKHGFVNGIY-----GAGNVGTAITTFAAPVVAKtagWENTVRMYiVLVAVFALLNFILG 180
Cdd:PRK09705 108 GVGIGIIQAVMPSVIKRRFQQRTPLVMGLWsaalmGGGGLGAAITPWLVQHSET---WYQTLAWW-ALPAVVALFAWWWQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 181 DRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVnHFGLDPVDSGlrtaGFIAVATFLRPVGGw 260
Cdd:PRK09705 184 SAREVASSHKTTTTPVRVVFTPRAWTLGVYFGLINGGYASLIAWLPAFYI-EIGASAQYSG----SLLALMTLGQAAGA- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 261 ladkfnplkLLMYVFAGCTLSGILLAFSPSLGLYGFG----------VLTVAVCaGLGNGIIFKL---VPLYFSNQAGIV 327
Cdd:PRK09705 258 ---------LLMPAMARHQDRRKLLMLALVLQLVGFCgfiwlplqlpVLWAMVC-GLGLGGAFPLcllLALDHSVQPAIA 327
|
330 340 350
....*....|....*....|....*....|....*.
gi 521287369 328 NGIVSAMGGLGGFFPPLI--LSSVFQA-TGHYAIGF 360
Cdd:PRK09705 328 GKLVAFMQGIGFIIAGLApwFSGVLRSiSGNYLMDW 363
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
115-375 |
4.32e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.42 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 115 GVTSLPKYYPKEKHGFVNGIYGAG-NVGTAITTFAAPVVAKTAGWENTVRMYIVLVAVFALLNFILgdrketkvtvsvte 193
Cdd:cd17312 112 CVKLLGNWFSKKERGTVYGIWSTShNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF-------------- 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 194 qmkAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSG-----LRTAGFIAVAtflrpVGGWLADK-FNP 267
Cdd:cd17312 178 ---LRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGwfsslYEVGGIAGTI-----LAGLLSDKlFGG 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 268 LKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKL-----VPLYFSNQAGIVNGIVSAMGGLGGFFP 342
Cdd:cd17312 250 RRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIggaaaQDIGRKEAAGTATGFVGLFGYLGASLA 329
|
250 260 270
....*....|....*....|....*....|...
gi 521287369 343 PLILSSVFQATGHYAIGFMALSEAALASFVIVV 375
Cdd:cd17312 330 GLPLGYIIDHYGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
42-373 |
4.52e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.38 E-value: 4.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 42 SEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILGGFFLGIGGA--VFSIGVTSL 119
Cdd:cd17353 38 ASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAgiGYITPVSTA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 120 PKYYPkEKHGFVNGIYGAG-NVGTAITTF-AAPVVAKTAGWENTVRMYIVLVAVFALLNFILGDRKETKVTVSVTEQMKA 197
Cdd:cd17353 118 VKWFP-DKRGLATGIVIAGfGLGSLIFSPlIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 198 VY------------RNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKF 265
Cdd:cd17353 197 AEnsprdytpremlRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 266 NPLKLLMYVFagcTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVP-----LYFSNQAGIVNGIVSAMGGLGGF 340
Cdd:cd17353 277 GRKNTLSIAF---LIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPaltadFFGTKNAGTNYGLLYTAKGVGGL 353
|
330 340 350
....*....|....*....|....*....|...
gi 521287369 341 FPPLIlSSVFQATGHYAIGFMALSEAALASFVI 373
Cdd:cd17353 354 IGPII-AAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
14-379 |
7.01e-06 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 48.00 E-value: 7.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 14 FSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTAD 93
Cdd:PLN00028 43 ISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 94 SLFDLILGGFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIY-GAGNVGTAITTFAAPVV---------AKTAGWentvR 163
Cdd:PLN00028 123 SATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAaGWGNLGGGVTQLLMPLVfplikdagaPSFTAW----R 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 164 MYIVLVAVFALLNFIL----------GDRKE-----TKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNF 228
Cdd:PLN00028 199 IAFFVPGLLHIIMGILvltlgqdlpdGNYRElkksgTMPKDSFSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEY 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 229 LVNHFGLDpvdsgLRTAGFIA-----VATFLRPVGGWLADKFNP-------LKLLMYVFAGCTLSGILLAFSPSLGLYGF 296
Cdd:PLN00028 279 FYDRFGLS-----LETAGAIAasfglMNLFARPAGGYLSDVAARrfgmrgrLWALWIVQTLGGVFCIWLGRANSLGAAIV 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 297 GVLTVAVCAGLGNGIIFKLVPLYFSNQAGIVNGIVSAMGGLGGFFPPLILSSvfQATGHYAIGFMALSEAALASFVIVVW 376
Cdd:PLN00028 354 VMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQLLFFT--GSSYSTETGISLMGVMIIACTLPVAF 431
|
...
gi 521287369 377 MYF 379
Cdd:PLN00028 432 IHF 434
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
48-378 |
1.29e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.83 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 48 TAIPVILGS------LLRIPLGYYTNRFGARITFMIS---FVLLLFPIFWIS-TADSLFDLILGGFFLGIGGAVFSIGVT 117
Cdd:cd17490 31 SMIGIILGAygisqmLLRIPLGILSDRIGKRKLFIIIgllFTVLASLIMILFpSPWGLLIARFLSGIAAATWVSFTVLYA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 118 SlpkYYPKEKHGFVNGIYGA-GNVGTAITTFAAPVVAKTAGWENTVRMYIVLVAVFALLNFILGDRKETKVTVSVTEQ-M 195
Cdd:cd17490 111 S---YFPPDEAAKAMGLINLvNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKeL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 196 KAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLA-DKFNPLKLLMYV 274
Cdd:cd17490 188 LSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 275 FAGCTLSGILLAFSPSLGLygfgVLTVAVCAGLGNGIIFKL--------VPlyfSNQAGIVNGIVSAMGGLGGFFPPLIL 346
Cdd:cd17490 268 FLLLGAYCFLIPFAPNLTL----LYLLQALNGFGTGILFPLlmslsiegVP---AEQRSTAMGFFQAIYALGMFLGPVLV 340
|
330 340 350
....*....|....*....|....*....|..
gi 521287369 347 SSVFQATGhYAIGFMALSEAALASFVIVVWMY 378
Cdd:cd17490 341 GIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
8-375 |
2.00e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.10 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 8 QLPLQSFSLVAGFmVWVLISSLMPHIKQDIALTDSEISLVTAIPVIlGSLLRIPL-GYYTNRFGARITFMISFVLLLFPI 86
Cdd:cd17393 1 RLAVAAFFFINGI-LMASWATRIPAIKDRLGLSDAALGLLLLALGV-GALVAMPLaGRLVARFGSRRVTRLGALLLLLAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 87 FWISTADSLFDLILGGFFLGIGGAV----FSIGVTSLPKYYPKEKHGFVNGIYGAGNVGTAITTFAAPVVAKTAGWENTV 162
Cdd:cd17393 79 LLLGLAPSVPALALALFLFGAANGAldvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 163 RMYIVLVA-VFALLNFILGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSG 241
Cdd:cd17393 159 AAVLLLLAaLVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 242 LRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVltvaVCAGLGngiIFKLVPLYFS 321
Cdd:cd17393 239 LGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGF----ALMGLG---LSVVVPLAFS 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521287369 322 ---NQAGIVNGI----VSAMGGLGGFFPPLILSSVFQATGhYAIGFMALSEAALASFVIVV 375
Cdd:cd17393 312 aagALPGLAAGIavarVATLGYLGFLVGPPLIGFLADATG-LRTAFLVVALLALLVALLAR 371
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
212-354 |
2.16e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 212 FITFGSFVAFTIYLpNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSL 291
Cdd:cd17352 13 FFTDGILNSFGVLF-VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSL 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 292 GLYgfgVLTVAVCAGLGNGIIFK----LVPLYFSNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATG 354
Cdd:cd17352 92 WQL---YLTYGVLGGLGLGLIYSpaivIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-362 |
2.36e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.03 E-value: 2.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 15 SLVAGFMVWVLISSLMPHIKqDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADS 94
Cdd:cd17330 8 DALGFGIVFPVLPFYVREFN-KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 95 LFDLILGGFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAgnvGTAITTFAAPVVAKTAGWENTVRMYIVLVAVFAL 174
Cdd:cd17330 87 LWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISA---AFGLGFILGPALGGFLSTPYGYALPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 175 LNFILgdrketkVTVSVTeqmkavyrnqTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGF-IAVATF 253
Cdd:cd17330 164 LNLVL-------VLFFLP----------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 254 LRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYF-SNQAGIVNGIVS 332
Cdd:cd17330 227 QLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVpSKEQGKAQGIIQ 306
|
330 340 350
....*....|....*....|....*....|
gi 521287369 333 AMGGLGGFFPPLILSSVFQATGHYAIGFMA 362
Cdd:cd17330 307 SLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
205-375 |
3.31e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 45.67 E-value: 3.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 205 WFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSG-LRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGI 283
Cdd:cd17331 210 AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGyLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 284 LLAFSPS-------LGLYGFGVLTVAVCAglgNGIIFKLVPlyfSNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHY 356
Cdd:cd17331 290 LLAFVTTvwqllvlLLPLVIGGSVLYTVI---TSLLTKAVP---PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFP 363
|
170
....*....|....*....
gi 521287369 357 AIGFMALSEAALASFVIVV 375
Cdd:cd17331 364 SFGLLGAAINGLLTVYLLL 382
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
212-376 |
3.59e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.60 E-value: 3.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 212 FITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMyvfAGCTLSGIL-LAFSPS 290
Cdd:cd17369 238 LAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYL---AGALLAALFaFPFFWL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 291 LGLYGFGVLTVA--VCAGLGNGIIFKLVPLYFSNQAGiVNGIVSAM-------GGLGGFFPPLILSSVFQATGHYAIGFM 361
Cdd:cd17369 315 LDTGSTWLIVLAavVVLGVLHGMMYGPQAAFLAELFP-TRVRYTGAslgyqlgAILGGGFAPLIATALVAATGSWWPVAL 393
|
170
....*....|....*
gi 521287369 362 ALSEAALASFVIVVW 376
Cdd:cd17369 394 YLAALAVISLVAALF 408
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
204-373 |
7.36e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 204 LWFLSLFYFITFGSFVAFtiyLPNFlVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGI 283
Cdd:cd17489 1 ILLANFFFFLSFYLLLPV---LPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 284 LLAFSPSLGL-------YGFGVLTVAVCAGLgngIIFKLVPlyfSNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHY 356
Cdd:cd17489 77 LYLLATSVALllvlrliHGIGWGAFTTAAAT---LVADIIP---PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA 150
|
170
....*....|....*..
gi 521287369 357 AIGFMALSEAALASFVI 373
Cdd:cd17489 151 VLFIVAAVLALLALLLV 167
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
135-347 |
7.50e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.52 E-value: 7.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 135 YGAGNVGTAITTFAAPVVAKTAGWENTVRMY------IVLVAVFALLNFILG------DRKETKVTVSVTEQMKAVYRNQ 202
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYfltaliIGIIGIILLLICFFGtrervvPPEEEKSKLPLLKSLKALLKNR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 203 TLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAgFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSG 282
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLL-ILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 283 ILLAFSPSLGLYGFGVLtvAVCAGLGNGIIFKLVPLYFS------------NQAGIVNGIVSAM----GGLGGFFPPLIL 346
Cdd:cd17332 301 LLLFFLPPGNLVLILVL--AVLAGIGYGGANLLPWAMLAdvidygelktgkRREGIFYSVMTFFrklgLALAGALVGLIL 378
|
.
gi 521287369 347 S 347
Cdd:cd17332 379 S 379
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
166-374 |
1.74e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 166 IVLVAVFALLNFILGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLrta 245
Cdd:cd17471 163 LLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL--- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 246 gFIAVATFLR----PVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSL----GLYGFGVLTVAVCAGLGNGIIFKLVP 317
Cdd:cd17471 240 -LFGLAAALEipimLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLwqliALQLLNAIFIGITAGLGISYFQDLMP 318
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 318 lyfsNQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIV 374
Cdd:cd17471 319 ----GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-380 |
2.05e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 12 QSFSLVAGFMVWVLISSLMphikQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMIS-----FVLLLFPI 86
Cdd:cd06173 8 QLLSALGDWIFTVALPWLV----LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 87 FWISTADSLFDLILGGFFLGIGGAVFSIGVTS-LPKYYPKEKHGFVNGIY-GAGNVGTAITTFAAPVVAKTAGWENTvrM 164
Cdd:cd06173 84 LALLGSLSLWLLLVLAFLLGIASAFFGPARQAlLPELVPKEQLVRANALNsLATQLARIIGPALGGLLVALLGPGGA--F 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 165 YIVLVAVFALLNFILGDRKETKVTVSVTEQMKA---------VYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGL 235
Cdd:cd06173 162 AINALSFLLSALLLLFIRRPPPAAPGESSSLLLrdlreglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 236 DPVDSGLRTAGF---IAVATFLrpvGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGII 312
Cdd:cd06173 242 GAAGYGLLLAAFgvgALLGALL---LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521287369 313 FKLVPLYFSNQ-AGIVNGIVSAMGGLGGFFPPLILSSVFQATGhyaiGFMALSEAALASFVIVVWMYFQ 380
Cdd:cd06173 319 NTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALG----LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-372 |
2.31e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 25 LISSLMPHIKQDIALTDSEISLVTAIP---VILGSLLripLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILG 101
Cdd:cd17477 14 LLLPLLSLRLEREGVSTALIGLVASAYylgILLGSPL---VPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 102 GFFLGIGGAVFSIGV-TSLPKYYPKEKHGFVNGIYGagnVGTAITTFAAPVVAKTAGwENTVRMYIVLVAVF--ALLNFI 178
Cdd:cd17477 91 RFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYS---TVLGLGFALGPLLLALVG-TAGALPFLIAAVLLllALVPLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 179 LGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYF-ITFGSFVAFtiyLPNFLVNHfGLDPVDSGLRTAGFIAVATFLRPV 257
Cdd:cd17477 167 LTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAgFLEGAFYSL---LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 258 GGWLADKFNPLKLLmyvfAGCTLSGILLAFSPSLGLYGFGVLtvAVCAGLGNGIIFKLVPL--------YFSNQAGIVNG 329
Cdd:cd17477 243 LGWLADRFDRRRVL----LGCALLGALAALLLPLVPGLPLAL--LVLLFLWGGAAGPLYTLalalagdrLPGDELVAANA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 521287369 330 IVSAMGGLGGFFPPLILSSVFQATGHYA-IGFMALSEAALASFV 372
Cdd:cd17477 317 ALLLLYGLGSVIGPLLAGALMDAFGPHGlFLFLAAVALLFLLFL 360
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
224-374 |
5.15e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.87 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 224 YLPNFLVNHfGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAV 303
Cdd:PRK11551 242 WLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGL 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 304 CAGLGNGIIFKLVPLYFSNQA-GIVNGIVSAMGGLGGFFPPLILSSVFqATGHYAIGFMALSE-----AALASFVIV 374
Cdd:PRK11551 321 FVVGGQSVLYALAPLFYPTQVrGTGVGAAVAVGRLGSMAGPLLAGQLL-ALGRSTVGVIGASIpvilvAALAALLLV 396
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
190-345 |
1.50e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.18 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 190 SVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPnFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLK 269
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALP-SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 270 LLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFS-NQAGIVNGIVSAMGGLGGFFPPLI 345
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLL 157
|
|
| MFS_NaGLT1_MFSD4B |
cd17454 |
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily ... |
143-287 |
1.58e-03 |
|
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily domain-containing protein 4B; Sodium-dependent glucose transporter 1 (NaGLT1) is also called major facilitator superfamily domain-containing protein 4B (MFSD4B). NaGLT1 is a primary fructose transporter in rat renal brush-border membranes. It also facilitates sodium-independent urea uptake in assays performed on Xenopus oocytes. NaGLT1/MFSD4B belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341012 Cd Length: 369 Bit Score: 40.12 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 143 AITTFAAPVVAKTAG-WENTV-RMYIVLVAVFALLNFILGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVA 220
Cdd:cd17454 130 ALGAFVAPILAKLAFlWAYIViGTYVLLVSLFFFILYSKSSSNREKSKASAQKTRFAKYHNALIILLFLFFFFYVGAEVT 209
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521287369 221 FTIYLPNFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAF 287
Cdd:cd17454 210 YGSYIFTYAKTYVHMEESEAAGLNSLFWGTFAACRGLAIFFAACLYPGTMILLSLIGSTVSSLFLVL 276
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-377 |
1.71e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 16 LVAGFMVWVLISSLmPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSL 95
Cdd:cd17504 6 LAVMLVETMLSPAL-PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 96 FDLILGGFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWentvRMYIVLVAVFAL 174
Cdd:cd17504 85 PVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFgIGAGIGLPLGGWIVQHLGW----RWIFWTAAPVAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 175 LNFILgdrketkVTVSVTEQMkavyRNQTLWFLS----LFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIAV 250
Cdd:cd17504 161 LLAAL-------VPLIDLRLL----RRRNVLLANitalLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 251 ATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSlGLYGFGVLTVAVCAGLGN------GIIFKLVPLYFSNQA 324
Cdd:cd17504 230 MLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHS-SLWALVVALLLIGIGLGLafaslpNIVVESVPPDRTGIA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521287369 325 GIVNGIVSAMGGLGGF---------FPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWM 377
Cdd:cd17504 309 TGMNTVLRTIGSAIGPaiagailttYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
148-361 |
1.75e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 40.28 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 148 AAPVVAKTAGWENTVRMYIVLVAVFALLNFILGDRKETKVTVSVTE------QMKAVYRNQTLWFLSLFYFITFGSFVAF 221
Cdd:cd17394 167 AELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEalgskgTLLRLLKNPHLRLGVLAIFFYVGAEVAI 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 222 TIYLPNFLV-NHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLM-YVFAGCTLSGILLAFSPSLGLYGFgvL 299
Cdd:cd17394 247 WSFLINYLMeYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAvFALLGLLLLLGAIFTGGMVALYAL--V 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521287369 300 TVAVCAGLGNGIIFKLVPLYFSNQAGIVNGIVSaMGGLGGFFPPLILSSVFQATGHYAIGFM 361
Cdd:cd17394 325 LVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLV-MAIVGGAVVPLIQGAVADDAAGLRIAFL 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
207-393 |
1.81e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 207 LSLFYFITFGSFVAFTIYLPNFLVnHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLA 286
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 287 FSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFS-NQAGIVNGIVSAMGGLGGFFPPLILSSVF-QATGHYAIGFMALS 364
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAA 159
|
170 180
....*....|....*....|....*....
gi 521287369 365 EAALASFVIVVWMYFQEVSKTSTKTKTNH 393
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEAS 188
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
26-228 |
2.11e-03 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 40.09 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 26 ISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWISTADSLFDLILGGFFL 105
Cdd:cd17410 18 VGPLLNEIRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 106 GIGGAVFSIGVTSLPKYYPKEKHGFVNGIYGAGNV-GTAITTFAAPVVAKT-AGWENTVRMYiVLVAVFALLNFILGDRK 183
Cdd:cd17410 98 GLGIAIIQALVPGLIKRRFPARVPLAMGLYSASLMaGGGLAASLSPRLAQHsAGWQLGLGIW-AVPALVALVLWWRQPPR 176
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 521287369 184 ETKVTVSVTEQMKaVYRNQTLWFLSLFYFITFGSFVAFTIYLPNF 228
Cdd:cd17410 177 EVAPSDTAGPGVR-FFRNRRAWLLALYFGLINAGYTSMIAWLPAY 220
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-180 |
2.20e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.85 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 14 FSLVAGFMVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGAR--ITFMISFVLLLFPIFWIST 91
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLAL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 92 ADSLF-DLILGGFFLGIGGAVFSIGVTSLPKYYPKEKHGFVNGI-YGAGNVGTAITTFAAPVVAKTAGWENTVRMYIVLV 169
Cdd:COG2271 268 LPSPAlAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLvNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
170
....*....|.
gi 521287369 170 AVFALLNFILG 180
Cdd:COG2271 348 LLAALLALLLL 358
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
204-313 |
3.06e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 39.54 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 204 LWFLSLFYFITFGSFVAFTIYLPNFLvNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGC-TLSG 282
Cdd:pfam12832 1 LWRLKGFYFFYFAALGCLLPYWGLYL-RSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILaAVLF 79
|
90 100 110
....*....|....*....|....*....|.
gi 521287369 283 ILLAFSPSLGLYGFGVLTVAVCAGLGNGIIF 313
Cdd:pfam12832 80 LSVLFIPISLTFWWLALLVVLFSFFWNAILP 110
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
221-378 |
4.01e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 4.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 221 FTIYLPnFLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLT 300
Cdd:TIGR00881 14 FALAMP-YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521287369 301 VAVCAGLGNGIIFKLVPLYFS-NQAGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIVVWMY 378
Cdd:TIGR00881 93 NGIFQGMGWPPCGRTVTKWFSrSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLL 171
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
13-374 |
4.19e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.93 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 13 SFSLVAGF-MVWVLISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWIST 91
Cdd:cd17314 8 SFLLSAMStGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 92 ADSLFDLILGGFFL--GIGGAVFSIGVTSLPKYYPKEKhGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWENTVRMYIVL 168
Cdd:cd17314 88 VFNSFPLSYACFVFigAGTGILYGSAVLVTTQYFPDTK-GLALGLPTTGYsLGLVLGSPLLRILWVFYGLALVYTILGIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 169 VAVFALLNFILGDRKETKVTVSV------TEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGL 242
Cdd:cd17314 167 AAIVLSVVSLLGFKEPPDNQARLhvqkkkTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 243 RTAGFIAVATFLRPVGGWLADKF-NPLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIF--KLVPLY 319
Cdd:cd17314 247 LMSIYGLFNAFGRLLWGIVADFFgGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVypATVSTV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 521287369 320 FSNQ-AGIVNGIVSAMGGLGGFFPPLILSSVFQATGHYAIGFMALSEAALASFVIV 374
Cdd:cd17314 327 FGTEsFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAIL 382
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
202-375 |
6.04e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 38.47 E-value: 6.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 202 QTLWFLSLFYFITFGSFV--AFTIYLPNfLVNHFGLDPVDSGLRTAGFIAVATFLRPVGGWLADKFNPLKLLMYVFAGCT 279
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNrkSFSFVLPS-LMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 280 LSGILLAFSPSLGLYGFGVLTVAVCAGLGNGIIFKLVPLYFS-NQAGIVNGIVSA----MGGLGGFFPPLILSSVFQATG 354
Cdd:cd17343 80 LTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSpSQFGTWWSVLSTsmnlAGSLGPILATLLALSYGWRST 159
|
170 180
....*....|....*....|.
gi 521287369 355 HYAIGFMALSEAALASFVIVV 375
Cdd:cd17343 160 LSISGTVAVVMSVVCLLFIKN 180
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-288 |
6.83e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 15 SLVAGFMVWV---LISSLMPHIKQDIALTDSEISLVTAIPVILGSLLRIPLGYYTNRFGARITFMISFVLLLFPIFWIST 91
Cdd:COG0477 19 LALGTFLEGLdftIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 92 ADSLFDLILGGFFLGIGGA-VFSIGVTSLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVAKTAGWENtvrMYIVLV 169
Cdd:COG0477 99 APSPELLIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIgLGLALGPLLGGLLVAALGWRW---IFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 170 AVFALLNFILGDRKETKVTVSVTEQMKAVYRNQTLWFLSLFYFITFGSFVAFTIYLPNFLVNHFGLDPVDSGLRTAGFIA 249
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|....*....
gi 521287369 250 VATFLRPVGGWLADKFNPLKLLMYVFAGCTLSGILLAFS 288
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
118-307 |
8.86e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 8.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 118 SLPKYYPKEKHGFVNGIYGAGN-VGTAITTFAAPVVA-------KTAGWENTVRMYIVLVAVfALLNFIL---------- 179
Cdd:PRK08633 127 IIPELVGKENLSRANGLLEAFTiVAILAGTALFSFLFesvngntPSEILGRIAPAGLVLLAV-AVLGLIFayrlpkvpaa 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 180 ----GDRKETKVTVSVTEQMKAVYRNQTLWF----LSLFYFItfGSFVAFTiyLPNFLVNHFGLDPVdsgLRTAGFIAVA 251
Cdd:PRK08633 206 apevFDKKKYLFPKLLWRNLKLLRSDRVLWLaiigLSYFWFI--SQLAQAN--FPAYAKEVLGLDNT---FQVQYLLAAS 278
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 521287369 252 TFLRPVGGWLADKFN----PLKLLMYVFAGCTLSGILLAFSPSLGLYGFGVLTVAVCAGL 307
Cdd:PRK08633 279 AIGIGIGSLLAGRLSgrhiELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGL 338
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