NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|522078838|ref|WP_020590047|]
View 

efflux RND transporter periplasmic adaptor subunit [Desulfobacter curvatus]

Protein Classification

efflux RND transporter periplasmic adaptor subunit( domain architecture ID 11436533)

efflux RND (resistance-nodulation-division) transporter periplasmic adaptor subunit, similar to Bacillus subtilis YknX, which is part of an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing

CATH:  2.40.50.100|2.40.420.20|2.40.30.170|1.10.287.470
Gene Ontology:  GO:0016020|GO:0055085|GO:0022857|GO:0042802
PubMed:  32073314
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 62-373 6.28e-87

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


:

Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 266.42  E-value: 6.28e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  62 RIQSRSVPADIQAIGSLEAVQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADRV-------AAAAKAAFSH 134
Cdd:COG0845    2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAqaqaqlaAAQAQLELAK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 135 LQLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQ-------KSIHAPFAGQIGIRRINLGQYLHAGDPIAT 207
Cdd:COG0845   82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQaranlayTTIRAPFDGVVGERNVEPGQLVSAGTPLFT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 208 LTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYVTARL 287
Cdd:COG0845  162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 288 QLPATTDAIVVPLTAIQTSAYGDSVVVVQElngegVGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQV 367
Cdd:COG0845  242 VLGERENALLVPASAVVRDGGGAYVFVVDA-----DGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKV 316


                 ....*.
gi 522078838 368 KVSASS 373
Cdd:COG0845  317 RVVEAA 322
 
Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 62-373 6.28e-87

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 266.42  E-value: 6.28e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  62 RIQSRSVPADIQAIGSLEAVQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADRV-------AAAAKAAFSH 134
Cdd:COG0845    2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAqaqaqlaAAQAQLELAK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 135 LQLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQ-------KSIHAPFAGQIGIRRINLGQYLHAGDPIAT 207
Cdd:COG0845   82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQaranlayTTIRAPFDGVVGERNVEPGQLVSAGTPLFT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 208 LTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYVTARL 287
Cdd:COG0845  162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 288 QLPATTDAIVVPLTAIQTSAYGDSVVVVQElngegVGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQV 367
Cdd:COG0845  242 VLGERENALLVPASAVVRDGGGAYVFVVDA-----DGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKV 316


                 ....*.
gi 522078838 368 KVSASS 373
Cdd:COG0845  317 RVVEAA 322
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 58-369 4.61e-73

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 230.66  E-value: 4.61e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838   58 VSASRIQSRSVPADIQAIGSLEAVQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADRVAAAAKAA------ 131
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAaaeaql 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  132 -FSHLQLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQKS-------IHAPFAGQIGIRRINLGQYLHAGD 203
Cdd:TIGR01730  81 eLAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQlnlryteIRAPFDGTIGRRLVEVGAYVTAGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  204 PIATLTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYV 283
Cdd:TIGR01730 161 TLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  284 TARLQLPATTDAIVVPLTAIQTSAYGDSVVVVQElngegVGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPP 363
Cdd:TIGR01730 241 RVTISLKVRSSAIVVPTQAVIEDLNGKYVYVVKN-----DGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRD 315


                  ....*.
gi 522078838  364 GAQVKV 369
Cdd:TIGR01730 316 GAKVKV 321
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
21-384 1.02e-34

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 132.61  E-value: 1.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  21 KPIFTSVVGLVIVFGLLFVWKTSRSESSSHPAQ------------------PPVLVSASRIQSRSVPADIQAIGSLEAVQ 82
Cdd:PRK11556   7 SRWVIVIVVVIAAIAAFWFWQGRSTSSSAAPGAakqaqqspaggrrgmrsgPLAPVQAATATEQAVPRYLTGLGTVTAAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  83 EVLLAPDTAGRITGIHFEAGQVVKEGTLL---------VQLYDAPEQ--ADRVAAAAkaafSHLQLSRSRELAPTGAEPR 151
Cdd:PRK11556  87 TVTVRSRVDGQLMALHFQEGQQVKAGDLLaeidprpfkVALAQAQGQlaKDQATLAN----ARRDLARYQQLAKTNLVSR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 152 ELLEQHQTEYEQAQAEVRQ-----LDARIQ--QKSIHAPFAGQIGIRRINLGQYLHAGD--PIATLTRLAPLYVNFTVPQ 222
Cdd:PRK11556 163 QELDAQQALVSETEGTIKAdeasvASAQLQldYSRITAPISGRVGLKQVDVGNQISSGDttGIVVITQTHPIDLVFTLPE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 223 QELAYL----EPGTQVQVTA--DSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYVTARLQLPATTDAI 296
Cdd:PRK11556 243 SDIATVvqaqKAGKPLVVEAwdRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNARMLVDTLQNAV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 297 VVPLTAIQTSAYGDSVVVVQELNgegvgKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQVKVSASSLNN 376
Cdd:PRK11556 323 VIPTAALQMGNEGHFVWVLNDEN-----KVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVEPQSAT 397


                 ....*...
gi 522078838 377 SDAAKSAP 384
Cdd:PRK11556 398 TPEEKATS 405
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 71-283 1.98e-24

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 99.50  E-value: 1.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838   71 DIQAIGSLEAVQE--VLLAPDTAGRITGIHFEA-GQVVKEGTLLVQLYdAPE----QADRVAAaakaafshLQLSRSREL 143
Cdd:pfam16576   5 TIRAVGRVAYDERrlAHVHARVEGWIEKLYVNAtGDPVKKGQPLAELY-SPElvaaQQEYLLA--------LRSGDALSK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  144 APTGAEPRELLEQhqteYEQAQAEVRQLDA--RIQQK-SIHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTV 220
Cdd:pfam16576  76 SELLRAARQRLRL----LGMPEAQIAELERtgKVQPTvTVYAPISGVVTELNVREGMYVQPGDTLFTIADLSTVWVEADV 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 522078838  221 PQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYV 283
Cdd:pfam16576 152 PEQDLALVKVGQPAEVTLPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGMFA 214
 
Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 62-373 6.28e-87

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 266.42  E-value: 6.28e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  62 RIQSRSVPADIQAIGSLEAVQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADRV-------AAAAKAAFSH 134
Cdd:COG0845    2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAqaqaqlaAAQAQLELAK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 135 LQLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQ-------KSIHAPFAGQIGIRRINLGQYLHAGDPIAT 207
Cdd:COG0845   82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQaranlayTTIRAPFDGVVGERNVEPGQLVSAGTPLFT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 208 LTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYVTARL 287
Cdd:COG0845  162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 288 QLPATTDAIVVPLTAIQTSAYGDSVVVVQElngegVGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQV 367
Cdd:COG0845  242 VLGERENALLVPASAVVRDGGGAYVFVVDA-----DGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKV 316


                 ....*.
gi 522078838 368 KVSASS 373
Cdd:COG0845  317 RVVEAA 322
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 58-369 4.61e-73

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 230.66  E-value: 4.61e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838   58 VSASRIQSRSVPADIQAIGSLEAVQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADRVAAAAKAA------ 131
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAaaeaql 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  132 -FSHLQLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQKS-------IHAPFAGQIGIRRINLGQYLHAGD 203
Cdd:TIGR01730  81 eLAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQlnlryteIRAPFDGTIGRRLVEVGAYVTAGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  204 PIATLTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYV 283
Cdd:TIGR01730 161 TLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  284 TARLQLPATTDAIVVPLTAIQTSAYGDSVVVVQElngegVGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPP 363
Cdd:TIGR01730 241 RVTISLKVRSSAIVVPTQAVIEDLNGKYVYVVKN-----DGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRD 315


                  ....*.
gi 522078838  364 GAQVKV 369
Cdd:TIGR01730 316 GAKVKV 321
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
21-384 1.02e-34

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 132.61  E-value: 1.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  21 KPIFTSVVGLVIVFGLLFVWKTSRSESSSHPAQ------------------PPVLVSASRIQSRSVPADIQAIGSLEAVQ 82
Cdd:PRK11556   7 SRWVIVIVVVIAAIAAFWFWQGRSTSSSAAPGAakqaqqspaggrrgmrsgPLAPVQAATATEQAVPRYLTGLGTVTAAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  83 EVLLAPDTAGRITGIHFEAGQVVKEGTLL---------VQLYDAPEQ--ADRVAAAAkaafSHLQLSRSRELAPTGAEPR 151
Cdd:PRK11556  87 TVTVRSRVDGQLMALHFQEGQQVKAGDLLaeidprpfkVALAQAQGQlaKDQATLAN----ARRDLARYQQLAKTNLVSR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 152 ELLEQHQTEYEQAQAEVRQ-----LDARIQ--QKSIHAPFAGQIGIRRINLGQYLHAGD--PIATLTRLAPLYVNFTVPQ 222
Cdd:PRK11556 163 QELDAQQALVSETEGTIKAdeasvASAQLQldYSRITAPISGRVGLKQVDVGNQISSGDttGIVVITQTHPIDLVFTLPE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 223 QELAYL----EPGTQVQVTA--DSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYVTARLQLPATTDAI 296
Cdd:PRK11556 243 SDIATVvqaqKAGKPLVVEAwdRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNARMLVDTLQNAV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 297 VVPLTAIQTSAYGDSVVVVQELNgegvgKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQVKVSASSLNN 376
Cdd:PRK11556 323 VIPTAALQMGNEGHFVWVLNDEN-----KVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVEPQSAT 397


                 ....*...
gi 522078838 377 SDAAKSAP 384
Cdd:PRK11556 398 TPEEKATS 405
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
56-289 9.68e-28

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 111.68  E-value: 9.68e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  56 VLVSASRIQSRSVPADIQAIGSLEAvQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADR------------ 123
Cdd:COG1566   19 LGLALWAAGRNGPDEPVTADGRVEA-RVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALaqaeaqlaaaea 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 124 ----------------------VAAAAKAAFSHLQLSRSRELAPTGAEPRELLEQHQTEY-------------------- 161
Cdd:COG1566   98 qlarleaelgaeaeiaaaeaqlAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALdaaqaqleaaqaqlaqaqag 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 162 --------------EQAQAEVRQLDARIQQKSIHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTVPQQELAY 227
Cdd:COG1566  178 lreeeelaaaqaqvAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVPLDDLWVEAYVPETDLGR 257

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 522078838 228 LEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQ-----------ALLPNADHELKSGMYVTARLQL 289
Cdd:COG1566  258 VKPGQPVEVRVDAYPDRVFEGKVTSISPGAGFTSPPKNATgnvvqrypvriRLDNPDPEPLRPGMSATVEIDT 330
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
88-383 2.15e-26

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 109.03  E-value: 2.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  88 PDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQA-------DRVAAAAKAAFSHLQLSRSRELAPTGAEPRELLEQHQTE 160
Cdd:PRK15030  70 PQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQAtydsakgDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALAD 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 161 YEQAQAEVRQLDARIQQKSIH-------APFAGQIGIRRINLGQYLHAGDP--IATLTRLAPLYVNFTVP-------QQE 224
Cdd:PRK15030 150 AQQANAAVTAAKAAVETARINlaytkvtSPISGRIGKSNVTEGALVQNGQAtaLATVQQLDPIYVDVTQSsndflrlKQE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 225 LAylePGTQVQVTADSSPDKVFEAHISSIEP--------RIDEETRNITVQALLPNADHELKSGMYVTARLQLPATTDAI 296
Cdd:PRK15030 230 LA---NGTLKQENGKAKVSLITSDGIKFPQDgtlefsdvTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAI 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 297 VVPLTAIQTSAYGDSVVVVQELNgegvGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQVKVSASSLNN 376
Cdd:PRK15030 307 LVPQQGVTRTPRGDATVLVVGAD----DKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADN 382


                 ....*..
gi 522078838 377 SDAAKSA 383
Cdd:PRK15030 383 NQQAASG 389
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 71-283 1.98e-24

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 99.50  E-value: 1.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838   71 DIQAIGSLEAVQE--VLLAPDTAGRITGIHFEA-GQVVKEGTLLVQLYdAPE----QADRVAAaakaafshLQLSRSREL 143
Cdd:pfam16576   5 TIRAVGRVAYDERrlAHVHARVEGWIEKLYVNAtGDPVKKGQPLAELY-SPElvaaQQEYLLA--------LRSGDALSK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  144 APTGAEPRELLEQhqteYEQAQAEVRQLDA--RIQQK-SIHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTV 220
Cdd:pfam16576  76 SELLRAARQRLRL----LGMPEAQIAELERtgKVQPTvTVYAPISGVVTELNVREGMYVQPGDTLFTIADLSTVWVEADV 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 522078838  221 PQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYV 283
Cdd:pfam16576 152 PEQDLALVKVGQPAEVTLPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGMFA 214
PRK09859 PRK09859
multidrug transporter subunit MdtE;
54-377 1.76e-23

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 100.56  E-value: 1.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  54 PPVLVSASRIQSRSVPADIQAIgsleavqevllAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQA-------DRVAA 126
Cdd:PRK09859  43 PGSVNVLSELPGRTVPYEVAEI-----------RPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAelnsakgSLAKA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 127 AAKAAFSHLQLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQKSIH-------APFAGQIGIRRINLGQYL 199
Cdd:PRK09859 112 LSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINlqyanvtSPITGVSGKSSVTVGALV 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 200 HA--GDPIATLTRLAPLYVNFTVPQQELAYLEP------------GTQVQVTADSSPDKVFEAHISSIEPRIDEETRNIT 265
Cdd:PRK09859 192 TAnqADSLVTVQRLDPIYVDLTQSVQDFLRMKEevasgqikqvqgSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVT 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 266 VQALLPNADHELKSGMYVTARLQLPATTDAIVVPLTAIQTSAYGDSVVVVqeLNGEGVgkVVTAPVKTGRRLGDNVLIEQ 345
Cdd:PRK09859 272 LRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALI--LDKDDV--VQLREIEASKAIGDQWVVTS 347

                        330       340       350
                 ....*....|....*....|....*....|..
gi 522078838 346 GLKTGDLVITAGQLRIPPGAQVKVSASSLNNS 377
Cdd:PRK09859 348 GLQAGDRVIVSGLQRIRPGIKARAISSSQENA 379
PRK09578 PRK09578
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
51-384 9.72e-19

MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 169982 [Multi-domain]  Cd Length: 385  Bit Score: 86.77  E-value: 9.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  51 PAQPPVLVSASRIQSR--SVPADIQAIGSLEAVQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQADRVAAA- 127
Cdd:PRK09578  29 DAAAAAPREATVVTVRptSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKQGAVLFRIDPAPLKAARDAAAg 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 128 --AKAAFSHL----QLSRSRELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQK-------SIHAPFAGQIgiRRIN 194
Cdd:PRK09578 109 alAKAEAAHLaaldKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAELARAqlqldyaTVTAPIDGRA--RRAL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 195 L------GQylHAGDPIATLTRLAPLYVNFTVPQQELAYLEPGT-----------QVQVT---ADSS----PDKVFEAHI 250
Cdd:PRK09578 187 VtegalvGQ--DQATPLTTVEQLDPIYVNFSQPAADVEALRRAVksgratgiaqqDVAVTlvrADGSeyplKGKLLFSDL 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 251 SsieprIDEETRNITVQALLPNADHELKSGMYVTARLQLPATTDAIVVPLTAIQTSAYGDSVVVVQElngegVGKVVTAP 330
Cdd:PRK09578 265 A-----VDPTTDTVAMRALFPNPERELLPGAYVRIALDRAVNPRAILVPRDALLRTADSASVKVVGQ-----NGKVRDVE 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522078838 331 VKTGRRLGDNVLIEQGLKTGDLVITAGQLRIPPGAQVKVsassLNNSDAAKSAP 384
Cdd:PRK09578 335 VEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVKA----VERAPAAKPAP 384
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 27-365 1.93e-17

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 82.90  E-value: 1.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  27 VVGLVIVFGLLFVWKTsrsESSSHPAQPPVLVsasriqsrsVPADIQ----AIGSLEAVQEVLLAPDTAGRITGIHFEAG 102
Cdd:PRK11578  13 IALVIVLAGGITLWRI---LNAPVPTYQTLIV---------RPGDLQqsvlATGKLDALRKVDVGAQVSGQLKTLSVAIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 103 QVVKEGTLLVQLydAPEQA----------------DRVAAAAKAAFSHLQLSRSRELAPTGAEPRELLEQHQTEYEQAQA 166
Cdd:PRK11578  81 DKVKKDQLLGVI--DPEQAenqikeveatlmelraQRQQAEAELKLARVTLSRQQRLAKTQAVSQQDLDTAATELAVKQA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 167 EVRQLDARIQQKS--------------IHAPFAGQIGIRRINLGQYLHAGDP---IATLTRLAPLYVNFTVPQQELAYLE 229
Cdd:PRK11578 159 QIGTIDAQIKRNQasldtaktnldytrIVAPMAGEVTQITTLQGQTVIAAQQapnILTLADMSTMLVKAQVSEADVIHLK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 230 PGTQVQVTADSSPDKVFEAHISSIEPRIDEETRNITVQAL--LPNADHELKSGMYVTARLQLPATTDAIVVPLTAIQTSA 307
Cdd:PRK11578 239 PGQKAWFTVLGDPLTRYEGVLKDILPTPEKVNDAIFYYARfeVPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPV 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522078838 308 yGDSVVVVQELNGegvGKVVTAPVKTGRRLGDNVLIEQGLKTGDLVITAgqlRIPPGA 365
Cdd:PRK11578 319 -GDNRYKVKLLRN---GETREREVTIGARNDTDVEIVKGLEAGDEVIIG---EAKPGA 369
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 180-280 1.78e-15

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 71.62  E-value: 1.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  180 IHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIEPRIDE 259
Cdd:pfam13437   2 IRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVDP 81

                          90       100
                  ....*....|....*....|...
gi 522078838  260 ETRNITVQALLPNADHE--LKSG 280
Cdd:pfam13437  82 DTGVIPVRVSIENPKTPipLLPG 104
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 68-355 8.62e-14

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 71.69  E-value: 8.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838   68 VPADIQAIGSLEAVQevllaPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQA-------DRVAAAAKAAFSHLQLSRS 140
Cdd:pfam00529  10 APGRVVVSGNAKAVQ-----PQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAaldsaeaQLAKAQAQVARLQAELDRL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  141 RELAPTGAEPRELLEQHQTEYEQAQAEVRQLDARIQQKSIH-------APFAGQIGIRRINLGQYLHAGDPI--ATLTRL 211
Cdd:pfam00529  85 QALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDlarrrvlAPIGGISRESLVTAGALVAQAQANllATVAQL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  212 APLYVNFTVPQQELAYLEPGTQVQVTADSSPDKV-----------------FEAHISSIEPRIDEETRNITVQALLPN-A 273
Cdd:pfam00529 165 DQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAelklakldlerteirapVDGTVAFLSVTVDGGTVSAGLRLMFVVpE 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  274 DHELKSGMYVTARLQLPATTDAIVVPLTAIQTSAYGDSVVVVQELNgegvGKVVTAPVKTGRRLGDNVLIEQGLKTGDLV 353
Cdd:pfam00529 245 DNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGIS----PDTGPVRVVVDKAQGPYYPLRIGLSAGALV 320


                  ..
gi 522078838  354 IT 355
Cdd:pfam00529 321 RL 322
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 81-294 7.69e-12

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 65.75  E-value: 7.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  81 VQEVLLAPDTAGRITGIHFEAGQVVKEGTLLVQLYDAPEQ---------------------------------ADRVAAA 127
Cdd:PRK03598  41 IRTVNLGFRVGGRLASLAVDEGDAVKAGQVLGELDAAPYEnalmqakanvsvaqaqldlmlagyrdeeiaqarAAVKQAQ 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 128 AKAAFSHLQLSRSRELAPTGAEPRELLEQHQTEYEQAQA-------------------EVRQLDARIQQ----------- 177
Cdd:PRK03598 121 AAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQAtlksaqdklsqyregnrpqDIAQAKASLAQaqaalaqaeln 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 178 ---KSIHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSSPDKVFEAHISSIE 254
Cdd:PRK03598 201 lqdTELIAPSDGTILTRAVEPGTMLNAGSTVFTLSLTRPVWVRAYVDERNLGQAQPGRKVLLYTDGRPDKPYHGQIGFVS 280

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522078838 255 PRID--------EETRNITVQAL---LPNADHELKSGMYVTARLQLPATTD 294
Cdd:PRK03598 281 PTAEftpktvetPDLRTDLVYRLrivVTDADDALRQGMPVTVRFADEAGHE 331
PRK09783 PRK09783
copper/silver efflux system membrane fusion protein CusB; Provisional
 165-367 2.40e-08

copper/silver efflux system membrane fusion protein CusB; Provisional


Pssm-ID: 236625 [Multi-domain]  Cd Length: 409  Bit Score: 55.64  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 165 QAEVRQLDA--RIQQK-SIHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTVPQQELAYLEPGTQVQVTADSS 241
Cdd:PRK09783 194 EADIRRLIAtrKIQTRfTLKAPIDGVITAFDLRAGMNIAKDNVVAKIQGMDPVWVTAAIPESIAWLVKDASQFTLTVPAR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 242 PDKVFEAHISSIEPRIDEETRNITVQALLPNADHELKSGMYVTARLQlPATTDAIVVPLTAIQTSAYGDSVVVVQElNGE 321
Cdd:PRK09783 274 PDKTFTIRKWTLLPSVDAATRTLQLRLEVDNADEALKPGMNAWLQLN-TASEPMLLIPSQALIDTGSEQRVITVDA-DGR 351

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 522078838 322 GVGKVVTAPVKTGRRLGdnvlIEQGLKTGDLVITAGQLRIPPGAQV 367
Cdd:PRK09783 352 FVPKRVAVFQESQGVTA----IRSGLAEGEKVVSSGLFLIDSEANI 393
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
84-253 8.87e-03

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 37.80  E-value: 8.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838  84 VLLAPDTAGRITGIHFEAGQVVKEGTLLVQLyDAP--EQADRVAAAAKAAFSHLQLSRSRELAP-----TGAEPRELLEQ 156
Cdd:PRK10559  48 VAIAPDVSGLITQVNVHDNQLVKKGQVLFTI-DQPryQKALAEAEADVAYYQVLAQEKRREAGRrnrlgVQAMSREEIDQ 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522078838 157 ---------HQTEYEQAQAEVRQLDarIQQKSIHAPFAGQIGIRRINLGQYLHAGDPIATLTRLAPLYVNFTVPQQELAY 227
Cdd:PRK10559 127 annvlqtvlHQLAKAQATRDLAKLD--LERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEG 204

                        170       180
                 ....*....|....*....|....*.
gi 522078838 228 LEPGTQVQVTADSSpDKVFEAHISSI 253
Cdd:PRK10559 205 VRPGYRAEITPLGS-NKVLKGTVDSV 229
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
84-124 9.49e-03

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 33.96  E-value: 9.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 522078838   84 VLLAPDTAGRITGIHFEAGQVVKEGTLLVQLyDAPEQADRV 124
Cdd:pfam13533   3 VKIASPVSGKVVAVNVKEGQQVKKGDVLATL-DSPELQLQL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH