|
Name |
Accession |
Description |
Interval |
E-value |
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
66-480 |
1.69e-130 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 385.79 E-value: 1.69e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 66 YNILLVVTDQERF-----FPTFPFPVPGRERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPyDL 140
Cdd:cd16035 1 PNILLILTDQERYpppwpAGWAALNLPARERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTLGSPMQP-LL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 141 DPALGTTGHMMRELGYYTAYKGKWHLTeklekplpdekdedidvgdipepelhkimekygfadyhgigdiiGHSKGGYFY 220
Cdd:cd16035 80 SPDVPTLGHMLRAAGYYTAYKGKWHLS--------------------------------------------GAAGGGYKR 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 221 DSTTTAQTINWLRCKGQPlNDQHKPWFLAVNLVNPHDVMFIdtdkegekvqwrgeldqddntlaptqppenelyqaswpn 300
Cdd:cd16035 116 DPGIAAQAVEWLRERGAK-NADGKPWFLVVSLVNPHDIMFP--------------------------------------- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 301 yplpanrhqsfneqgrppahleyqtaraalegqfPDEDRRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFT 380
Cdd:cd16035 156 ----------------------------------PDDEERWRRFRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFT 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 381 ADHGELGGSHQMHGKGASVYKEQIHVPMIISHPAYPGN-RKCQALTCHLDIAPTLVGLTGLPEEKQHQALGNRKGVNFSG 459
Cdd:cd16035 202 SDHGEMGGAHGLRGKGFNAYEEALHVPLIISHPDLFGTgQTTDALTSHIDLLPTLLGLAGVDAEARATEAPPLPGRDLSP 281
|
410 420
....*....|....*....|.
gi 555243212 460 LLKNPEGvavNAVRNASLYCY 480
Cdd:cd16035 282 LLTDADA---DAVRDGILFTY 299
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
67-598 |
7.33e-61 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 207.81 E-value: 7.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFPVPGRE-----RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPydLD 141
Cdd:COG3119 25 NILFILADDLGYGDLGCYGNPLIKtpnidRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGEGYNGG--LP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 142 PALGTTGHMMRELGYYTAYKGKWHLTeklekplpdekdedidvgdipepelhkimekygfadyhgigdiighskggyfYD 221
Cdd:COG3119 103 PDEPTLAELLKEAGYRTALFGKWHLY----------------------------------------------------LT 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 222 STTTAQTINWLRckgqPLNDQHKPWFLAVNLVNPHDvmfidtdkegekvqwrgeldqddntlaPTQPPEN--ELYQASwp 299
Cdd:COG3119 131 DLLTDKAIDFLE----RQADKDKPFFLYLAFNAPHA---------------------------PYQAPEEylDKYDGK-- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 300 NYPLPANRHQSfneqgrppahleyqtaraalegqfPDEDRRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVF 379
Cdd:COG3119 178 DIPLPPNLAPR------------------------DLTEEELRRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVF 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 380 TADHGELGGSHQMHGKGASVYKEQIHVPMIISHPA-YPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrkGVNFS 458
Cdd:COG3119 234 TSDNGPSLGEHGLRGGKGTLYEGGIRVPLIVRWPGkIKAGSVSDALVSLIDLLPTLLDLAGVPIPEDLD------GRSLL 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 459 GLLKNPEGvavnAVRnaslycygmilytDAHYLHrvialqrdkqktvaqikqeishlhpdFSHRSGTRMINDGRYKFARY 538
Cdd:COG3119 308 PLLTGEKA----EWR-------------DYLYWE--------------------------YPRGGGNRAIRTGRWKLIRY 344
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 539 fslreHNTPETWedlikyndlELYDLKNDPDENHNLAADkqkYQDLILTMNEKLNKIIKD 598
Cdd:COG3119 345 -----YDDDGPW---------ELYDLKNDPGETNNLAAD---YPEVVAELRALLEAWLKE 387
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
91-593 |
5.65e-49 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 176.57 E-value: 5.65e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGlPWMPYDLD--PALgttghmMRELGYYTAYKGKWHLTE 168
Cdd:cd16031 33 RLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVTDNNG-PLFDASQPtyPKL------LRKAGYQTAFIGKWHLGS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 169 klekplpdekdedidVGDIPEPELHKIMEKYGFADYHGIGDIIG---HSKGGYFYDSTTtAQTINWLRckgqpLNDQHKP 245
Cdd:cd16031 106 ---------------GGDLPPPGFDYWVSFPGQGSYYDPEFIENgkrVGQKGYVTDIIT-DKALDFLK-----ERDKDKP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 246 WFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPTQPPEN--ELYQASwpNYPLPANrhqsFNEQ---GRPPAh 320
Cdd:cd16031 165 FCLSLSFKAPH---------------------------RPFTPAPRhrGLYEDV--TIPEPET----FDDDdyaGRPEW- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 321 leyqtARAALEGQFPDEDRRWRKLLDY------YFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHG 394
Cdd:cd16031 211 -----AREQRNRIRGVLDGRFDTPEKYqrymkdYLRTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDNGFFLGEHGLFD 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 395 KgASVYKEQIHVPMIISHP-AYPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrkGVNFSGLLKNPEGVavnAVR 473
Cdd:cd16031 286 K-RLMYEESIRVPLIIRDPrLIKAGTVVDALVLNIDFAPTILDLAGVPIPEDMQ------GRSLLPLLEGEKPV---DWR 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 474 NASLYcygmilytdaHYLHrvialqrdkqktvaqikqeishlHPDFSHRSGTRMINDGRYKFARYfslreHNTPETWedl 553
Cdd:cd16031 356 KEFYY----------EYYE-----------------------EPNFHNVPTHEGVRTERYKYIYY-----YGVWDEE--- 394
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 555243212 554 ikyndlELYDLKNDPDENHNLAADKQkYQDLILTMNEKLN 593
Cdd:cd16031 395 ------ELYDLKKDPLELNNLANDPE-YAEVLKELRKRLE 427
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
91-594 |
6.09e-49 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 175.00 E-value: 6.09e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPYDLDPALGttgHMMRELGYYTAYKGKWHLTekl 170
Cdd:cd16027 30 RLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGAHGLRSRGFPLPDGVKTLP---ELLREAGYYTGLIGKTHYN--- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 171 ekplPDEKDEDIDVGDIPEPELHKIMEKYGFADyhgigdiighskggyfydstttaqtiNWLRCKgqplnDQHKPWFLAV 250
Cdd:cd16027 104 ----PDAVFPFDDEMRGPDDGGRNAWDYASNAA--------------------------DFLNRA-----KKGQPFFLWF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 251 NLVNPHdVMFIDTDKEGEKVqwrgelDQDDNTLAPtqppenelyqaswpNYP-LPANRHQsfneqgrppahleyqtaraa 329
Cdd:cd16027 149 GFHDPH-RPYPPGDGEEPGY------DPEKVKVPP--------------YLPdTPEVRED-------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 330 legqfpdedrrwrkLLDYYfNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGelggsHQMHGKGASVYKEQIHVPMI 409
Cdd:cd16027 188 --------------LADYY-DEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHG-----MPFPRAKGTLYDSGLRVPLI 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 410 ISHPA-YPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrkGVNFSGLLKNPEGVAVNAVrnaslycYGMILYTDA 488
Cdd:cd16027 248 VRWPGkIKPGSVSDALVSFIDLAPTLLDLAGIEPPEYLQ------GRSFLPLLKGEKDPGRDYV-------FAERDRHDE 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 489 HYLHRvialqrdkqktvaqikqeishlhpdfshrsgtRMINDGRYKFARYFslrehnTPEtwedlikyndlELYDLKNDP 568
Cdd:cd16027 315 TYDPI--------------------------------RSVRTGRYKYIRNY------MPE-----------ELYDLKNDP 345
|
490 500
....*....|....*....|....*.
gi 555243212 569 DENHNLAADKqKYQDLILTMNEKLNK 594
Cdd:cd16027 346 DELNNLADDP-EYAEVLEELRAALDA 370
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
91-574 |
1.21e-44 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 163.89 E-value: 1.21e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNlGLPwmpydLDPALGTTGHMMRELGYYTAYKGKWHLTEkl 170
Cdd:cd16034 32 RLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVFGN-DVP-----LPPDAPTIADVLKDAGYRTGYIGKWHLDG-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 171 ekplpDEKDEDIDVGDIPEPELhkimeKYGFADYHGIGDIIGHSKGGYFYDSTT------------TAQTINWLRCKGqp 238
Cdd:cd16034 104 -----PERNDGRADDYTPPPER-----RHGFDYWKGYECNHDHNNPHYYDDDGKriyikgyspdaeTDLAIEYLENQA-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 239 lnDQHKPWFLAVNLVNPHDVMfiDTDKEGEKVQWrgelDQDDNTLAPTQPPEnelyqaswpnyplpanrhqsfneqgrpp 318
Cdd:cd16034 172 --DKDKPFALVLSWNPPHDPY--TTAPEEYLDMY----DPKKLLLRPNVPED---------------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 319 ahleyqtaraalegqfPDEDRRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHGKGaS 398
Cdd:cd16034 216 ----------------KKEEAGLREDLRGYYAMITALDDNIGRLLDALKELGLLENTIVVFTSDHGDMLGSHGLMNKQ-V 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 399 VYKEQIHVPMIISHPA-YPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrkGVNFSGLLKNPEGvavNAVRNASL 477
Cdd:cd16034 279 PYEESIRVPFIIRYPGkIKAGRVVDLLINTVDIMPTLLGLCGLPIPDTVE------GRDLSPLLLGGKD---DEPDSVLL 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 478 YCygmILYTDAHYlhrvialqrdkqktvaqikqeishlhpdFSHRSGTRMINDGRYKFARYFSlrehntPETWedlikyn 557
Cdd:cd16034 350 QC---FVPFGGGS----------------------------ARDGGEWRGVRTDRYTYVRDKN------GPWL------- 385
|
490
....*....|....*..
gi 555243212 558 dleLYDLKNDPDENHNL 574
Cdd:cd16034 386 ---LFDNEKDPYQLNNL 399
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
67-592 |
4.01e-44 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 162.78 E-value: 4.01e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFPVPGR-----ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPwMPYDLD 141
Cdd:cd16033 2 NILFIMTDQQRYDTLGCYGNPIVktpniDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVENA-GAYSRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 142 PALG--TTGHMMRELGYYTAYKGKWHLteklekpLPDEKDEDidvgdipepelhkimekYGFADYHGIGDIIGHskggyf 219
Cdd:cd16033 81 LPPGveTFSEDLREAGYRNGYVGKWHV-------GPEETPLD-----------------YGFDEYLPVETTIEY------ 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 220 ydsTTTAQTINWLRckgqPLNDQHKPWFLAVNLVNPHDVMFidtdkegekvqwrgeldqddntlaptqPPEN--ELYQAS 297
Cdd:cd16033 131 ---FLADRAIEMLE----ELAADDKPFFLRVNFWGPHDPYI---------------------------PPEPylDMYDPE 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 298 wpNYPLPANRHQSFNeqGRPPAHLEYqtarAALEGQFPDEDRRWRKLLDYYFNCIrdcdTHLD----RILNELDALKLTD 373
Cdd:cd16033 177 --DIPLPESFADDFE--DKPYIYRRE----RKRWGVDTEDEEDWKEIIAHYWGYI----TLIDdaigRILDALEELGLAD 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 374 KTIVVFTADHGELGGSHQMHGKGASVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLPEEKqhqalgnr 452
Cdd:cd16033 245 DTLVIFTSDHGDALGAHRLWDKGPFMYEETYRIPLIIKWPGViAAGQVVDEFVSLLDLAPTILDLAGVDVPP-------- 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 453 kgvNFSG--LLKNPEGVAVNAVRNAslycygmiLYTDAHYLHrvialqrdkqktvaqikqeishlhpdFSHRSgtRMIND 530
Cdd:cd16033 317 ---KVDGrsLLPLLRGEQPEDWRDE--------VVTEYNGHE--------------------------FYLPQ--RMVRT 357
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 555243212 531 GRYKFAryfslreHNTPEtwedlikYNdlELYDLKNDPDENHNLAADKQkYQDLILTMNEKL 592
Cdd:cd16033 358 DRYKYV-------FNGFD-------ID--ELYDLESDPYELNNLIDDPE-YEEILREMRTRL 402
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
90-569 |
1.55e-39 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 147.69 E-value: 1.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLglpwMPYDLDPAlgTTGHMMRELGYYTAYKGKWHltek 169
Cdd:cd16037 30 DRLAARGTRFENAYTPSPICVPSRASFLTGRYVHETGVWDNA----DPYDGDVP--SWGHALRAAGYETVLIGKLH---- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 170 lekplpdekdedidvgdipepelhkimekygfadYHGIGDiighsKGGYFYDSTTTAQTINWLRCKGQplndQHKPWFLA 249
Cdd:cd16037 100 ----------------------------------FRGEDQ-----RHGFRYDRDVTEAAVDWLREEAA----DDKPWFLF 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 250 VNLVNPHdvmfidtdkegekvqwrgeldqddntlaptqppenelyqaswpnYPLPAnrhqsfneqgrPPAHLEY--QTAR 327
Cdd:cd16037 137 VGFVAPH--------------------------------------------FPLIA-----------PQEFYDLyvRRAR 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 328 AAlegqfpdedrrwrklldyYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHGKGaSVYKEQIHVP 407
Cdd:cd16037 162 AA------------------YYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHGDMLGERGLWGKS-TMYEESVRVP 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 408 MIISHPAYPGNRKCQALTCHLDIAPTLVGLTGLPEekqhqaLGNRKGVNFSGLLKNPEgvavnavrnaslycygmilytd 487
Cdd:cd16037 223 MIISGPGIPAGKRVKTPVSLVDLAPTILEAAGAPP------PPDLDGRSLLPLAEGPD---------------------- 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 488 ahylhrvialqrDKQKTVaqikqeISHLHPDFShRSGTRMINDGRYKFARYFSLREhntpetwedlikyndlELYDLKND 567
Cdd:cd16037 275 ------------DPDRVV------FSEYHAHGS-PSGAFMLRKGRWKYIYYVGYPP----------------QLFDLEND 319
|
..
gi 555243212 568 PD 569
Cdd:cd16037 320 PE 321
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
91-579 |
1.86e-39 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 150.42 E-value: 1.86e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNlglpwmPYDLDPALG--TT--GHMmRELGYYTAYKGK-WH 165
Cdd:cd16030 32 RLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGVYDN------NSYFRKVAPdaVTlpQYF-KENGYTTAGVGKiFH 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 166 lteklekplPDEKDEDIDVGDIPEPELHKIMEKYGFADYHGIGDIIGHSKGGYFYDST-----------TTAQTINWLRC 234
Cdd:cd16030 105 ---------PGIPDGDDDPASWDEPPNPPGPEKYPPGKLCPGKKGGKGGGGGPAWEAAdvpdeaypdgkVADEAIEQLRK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 235 KGqplnDQHKPWFLAVNLVNPHdvmfidtdkegekVQWRgeldqddntlAPTQ-----PPENELYQASWPNYPLPANRHQ 309
Cdd:cd16030 176 LK----DSDKPFFLAVGFYKPH-------------LPFV----------APKKyfdlyPLESIPLPNPFDPIDLPEVAWN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 310 SFNEqgRPPAHLEYQTARAALEGQFPDEdrRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGS 389
Cdd:cd16030 229 DLDD--LPKYGDIPALNPGDPKGPLPDE--QARELRQAYYASVSYVDAQVGRVLDALEELGLADNTIVVLWSDHGWHLGE 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 390 HQMHGKgASVYKEQIHVPMIISHPAYPG-NRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrkGVNFSGLLKNPEgva 468
Cdd:cd16030 305 HGHWGK-HTLFEEATRVPLIIRAPGVTKpGKVTDALVELVDIYPTLAELAGLPAPPCLE------GKSLVPLLKNPS--- 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 469 vNAVRNASLycygmilytdahylhrvialqrdkqktvaqikqeISHLHPDFSHRSgtrmINDGRYKFARyfslrehntpe 548
Cdd:cd16030 375 -AKWKDAAF----------------------------------SQYPRPSIMGYS----IRTERYRYTE----------- 404
|
490 500 510
....*....|....*....|....*....|.
gi 555243212 549 tWEDLIKYNDLELYDLKNDPDENHNLAADKQ 579
Cdd:cd16030 405 -WVDFDKVGAEELYDHKNDPNEWKNLANDPE 434
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
90-594 |
4.02e-39 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 148.85 E-value: 4.02e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGL------------PWMPYDLDPALGTTGHMMRELGYY 157
Cdd:cd16144 30 DRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGITDVIPGrrgppdntklipPPSTTRLPLEEVTIAEALKDAGYA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 158 TAYKGKWHLTEKlEKPLPDEK--DEDIDVGDIPEPElhkimeKYGFADYHGIGDIIGHSKGGYFYDSTTTaQTINWLRck 235
Cdd:cd16144 110 TAHFGKWHLGGE-GGYGPEDQgfDVNIGGTGNGGPP------SYYFPPGKPNPDLEDGPEGEYLTDRLTD-EAIDFIE-- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 236 gqplNDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPTQPPENEL--YQAswpnYPLPANRHQSfne 313
Cdd:cd16144 180 ----QNKDKPFFLYLSHYAVH---------------------------TPIQARPELIekYEK----KKKGLRKGQK--- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 314 qgrppaHLEYqtarAALegqfpdedrrwrklldyyfncIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMH 393
Cdd:cd16144 222 ------NPVY----AAM---------------------IESLDESVGRILDALEELGLADNTLVIFTSDNGGLSTRGGPP 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 394 --------GKGaSVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQAlgnrKGVNFSGLLKNP 464
Cdd:cd16144 271 tsnaplrgGKG-SLYEGGIRVPLIVRWPGViKPGSVSDVPVIGTDLYPTFLELAGGPLPPPQHL----DGVSLVPLLKGG 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 465 EGvavNAVRNAslycygmiLYTdaHYLHrvialqrdkqktvaqikqeishlhpdfSHRSGTRM---INDGRYKFARYFsl 541
Cdd:cd16144 346 EA---DLPRRA--------LFW--HFPH---------------------------YHGQGGRPasaIRKGDWKLIEFY-- 383
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 555243212 542 rehntpETWEdlikyndLELYDLKNDPDENHNLAAdkqKYQDLILTMNEKLNK 594
Cdd:cd16144 384 ------EDGR-------VELYNLKNDIGETNNLAA---EMPEKAAELKKKLDA 420
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
91-593 |
1.36e-38 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 146.17 E-value: 1.36e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCN--HQNTSN--VCTPSRSVLYTGLHM----PQTKMFDNLGLPWMPYdldpalgttghMMRELGYYTAYKG 162
Cdd:cd16155 33 RLARRGTSFTNayNMGGWSgaVCVPSRAMLMTGRTLfhapEGGKAAIPSDDKTWPE-----------TFKKAGYRTFATG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 163 KWHLteklekplpdekdedidvgdipepelhkimekyGFADyhgigdiighskggyfydstttaQTINWLrcKGQPLNDq 242
Cdd:cd16155 102 KWHN---------------------------------GFAD-----------------------AAIEFL--EEYKDGD- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 243 hKPWFLAVNLVNPHDvmfidtdkegekvqwrgeldqddntlaPTQPPEN--ELYQASwpNYPLPANrhqsFneqgrPPAH 320
Cdd:cd16155 123 -KPFFMYVAFTAPHD---------------------------PRQAPPEylDMYPPE--TIPLPEN----F-----LPQH 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 321 LEYQTARA----ALEGqFP-DEDRRWRKLLDYYfNCIrdcdTHLD----RILNELDALKLTDKTIVVFTADHGELGGSHQ 391
Cdd:cd16155 164 PFDNGEGTvrdeQLAP-FPrTPEAVRQHLAEYY-AMI----THLDaqigRILDALEASGELDNTIIVFTSDHGLAVGSHG 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 392 MHGKgASVYKEQIHVPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrkGVNFSGLLKNPEgvavNA 471
Cdd:cd16155 238 LMGK-QNLYEHSMRVPLIISGPGIPKGKRRDALVYLQDVFPTLCELAGIEIPESVE------GKSLLPVIRGEK----KA 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 472 VRNASLYCYgmilytdahylhrvialqrdkqktvaqikqeishlhpdfshRSGTRMINDGRYKFARYfslrehnTPETwe 551
Cdd:cd16155 307 VRDTLYGAY-----------------------------------------RDGQRAIRDDRWKLIIY-------VPGV-- 336
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 555243212 552 dlikyNDLELYDLKNDPDENHNLAADKqKYQDLILTMNEKLN 593
Cdd:cd16155 337 -----KRTQLFDLKKDPDELNNLADEP-EYQERLKKLLAELK 372
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
67-592 |
1.70e-35 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 139.32 E-value: 1.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFpvpGR--------ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNlGLPwmpy 138
Cdd:cd16028 2 NVLFITADQWRADCLSCL---GHplvktpnlDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSVWN-GTP---- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 139 dLDPALGTTGHMMRELGYYTAYKGKWHLTeklekPLPD---EKDEDIDVGDIPEPelhkimekyGFADY---HGIGDiiG 212
Cdd:cd16028 74 -LDARHLTLALELRKAGYDPALFGYTDTS-----PDPRglaPLDPRLLSYELAMP---------GFDPVdrlDEYPA--E 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 213 HSKGGYFYDstttaQTINWLRCKGQplndqhKPWFLAVNLVNPHdvmfidtdkegekvqWrgeldqddNTLAPTqpPENE 292
Cdd:cd16028 137 DSDTAFLTD-----RAIEYLDERQD------EPWFLHLSYIRPH---------------P--------PFVAPA--PYHA 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 293 LYQASwpNYPLPaNRHQSFNEQGRP-P---AHLEYQTARAALEGQFPDED------RRWRKLldyYFNCIRDCDTHLDRI 362
Cdd:cd16028 181 LYDPA--DVPPP-IRAESLAAEAAQhPllaAFLERIESLSFSPGAANAADlddeevAQMRAT---YLGLIAEVDDHLGRL 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 363 LNELDALKLTDKTIVVFTADHGELGGSHQMHGKGAsVYKEQIHVPMIISHPAYPGN----RKCQALTCHLDIAPTLVGLT 438
Cdd:cd16028 255 FDYLKETGQWDDTLIVFTSDHGEQLGDHWLWGKDG-FFDQAYRVPLIVRDPRREADatrgQVVDAFTESVDVMPTILDWL 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 439 GLPEEKQHQalgnrkGVNFSGLLknpEGVAVNAVRNASLYCYgmiLYTDAHYLHRVIALQRDkqktvaqikqeishlhpd 518
Cdd:cd16028 334 GGEIPHQCD------GRSLLPLL---AGAQPSDWRDAVHYEY---DFRDVSTRRPQEALGLS------------------ 383
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555243212 519 fSHRSGTRMINDGRYKfaryfslrehntpetwedLIKYNDLE--LYDLKNDPDENHNLAADKqKYQDLILTMNEKL 592
Cdd:cd16028 384 -PDECSLAVIRDERWK------------------YVHFAALPplLFDLKNDPGELRDLAADP-AYAAVVLRYAQKL 439
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
67-441 |
8.19e-34 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 129.09 E-value: 8.19e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFpvpGRE--------RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHmPQTkmFDNLGLPWMPY 138
Cdd:cd16022 2 NILLIMTDDLGYDDLGCY---GNPdiktpnldRLAAEGVRFTNAYVASPVCSPSRASLLTGRY-PHR--HGVRGNVGNGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 139 DLDPALGTTGHMMRELGYYTAYKGKWHlteklekplpdekdedidvgdipepelhkimekygfadyhgigdiighskggy 218
Cdd:cd16022 76 GLPPDEPTLAELLKEAGYRTALIGKWH----------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 219 fydstttAQTINWLRckgqpLNDQHKPWFLAVNLVNPHDvmfidtdkegekvqwrgeldqddntlaptqppenelyqasw 298
Cdd:cd16022 103 -------DEAIDFIE-----RRDKDKPFFLYVSFNAPHP----------------------------------------- 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 299 pnyPLpanrhqsfneqgrppahleyqtaraalegqfpdedrrwrklldYYFNCIRDCDTHLDRILNELDALKLTDKTIVV 378
Cdd:cd16022 130 ---PF-------------------------------------------AYYAMVSAIDDQIGRILDALEELGLLDNTLIV 163
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 555243212 379 FTADHGELGGSHQMHGKGASVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLP 441
Cdd:cd16022 164 FTSDHGDMLGDHGLRGKKGSLYEGGIRVPFIVRWPGKiPAGQVSDALVSLLDLLPTLLDLAGIE 227
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
91-447 |
2.31e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 126.12 E-value: 2.31e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHmpqtkmfdnlGLPWMPY--DLDPALGTTGHMMRELGYYTAYkgkwhlte 168
Cdd:cd16148 31 RLAAEGVVFDNHYSGSNPTLPSRFSLFTGLY----------PFYHGVWggPLEPDDPTLAEILRKAGYYTAA-------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 169 klekplpdekdedidVGDIP----EPELHKimekyGFADYHGIGDIIG-HSKGGYFYDSTTTAQTINWLRckgqpLNDQH 243
Cdd:cd16148 93 ---------------VSSNPhlfgGPGFDR-----GFDTFEDFRGQEGdPGEEGDERAERVTDRALEWLD-----RNADD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 244 KPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlaptqppenELYQaswpnyplpanrhqsfneqgrppahley 323
Cdd:cd16148 148 DPFFLFLHYFDPH-----------------------------------EPYL---------------------------- 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 324 qtaraalegqfpdedrrwrklldyYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGE-LGGSHQMHGKGASVYKE 402
Cdd:cd16148 165 ------------------------YDAEVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHGEeFGEHGLYWGHGSNLYDE 220
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 555243212 403 QIHVPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQ 447
Cdd:cd16148 221 QLHVPLIIRWPGKEPGKRVDALVSHIDIAPTLLDLLGVEPPDYSD 265
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
67-598 |
2.79e-30 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 122.72 E-value: 2.79e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFpvpGRE--------RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNlGLPwmpy 138
Cdd:cd16152 3 NVIVFFTDQQRWDTLGCY---GQPldltpnldALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGCFRN-GIP---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 139 dLDPALGTTGHMMRELGYYTAYKGKWHLteklekplpdekdedidvgdipepelhkimekygfadyhgigdiighskGGY 218
Cdd:cd16152 75 -LPADEKTLAHYFRDAGYETGYVGKWHL-------------------------------------------------AGY 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 219 FYDSTTTAqTINWLRCKgqplnDQHKPWFLAVNLVNPHDvmfidtdkegekvqwrgeldqdDNTLAPTQPPENelYQASW 298
Cdd:cd16152 105 RVDALTDF-AIDYLDNR-----QKDKPFFLFLSYLEPHH----------------------QNDRDRYVAPEG--SAERF 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 299 PNYPLPANRhqsfneqgrppahleyqtarAALEGQfpdedrrWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVV 378
Cdd:cd16152 155 ANFWVPPDL--------------------AALPGD-------WAEELPDYLGCCERLDENVGRIRDALKELGLYDNTIIV 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 379 FTADHgelgGSHQMHGKGAsvYKEQ-----IHVPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTGL--PEEKQhqalgn 451
Cdd:cd16152 208 FTSDH----GCHFRTRNAE--YKRSchessIRVPLVIYGPGFNGGGRVEELVSLIDLPPTLLDAAGIdvPEEMQ------ 275
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 452 rkGVNFSGLLKNpegvAVNAVRNASLycygmilytdahylhrvialqrdkqktvAQIKQeishlhpdfsHRSGtRMINDG 531
Cdd:cd16152 276 --GRSLLPLVDG----KVEDWRNEVF----------------------------IQISE----------SQVG-RAIRTD 310
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 555243212 532 RYKFARYFSlrehnTPETWEDL--IKYNDLELYDLKNDPDENHNLAADKQkYQDLILTMNEKLNKIIKD 598
Cdd:cd16152 311 RWKYSVAAP-----DKDGWKDSgsDVYVEDYLYDLEADPYELVNLIGRPE-YREVAAELRERLLARMAE 373
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
67-441 |
3.57e-29 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 119.96 E-value: 3.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTD-QERFFPTFPFPVPGRERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNlGLPWMPYDLDPALG 145
Cdd:cd16147 3 NIVLILTDdQDVELGSMDPMPKTKKLLADQGTTFTNAFVTTPLCCPSRASILTGQYAHNHGVTNN-SPPGGGYPKFWQNG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 146 ----TTGHMMRELGYYTAYKGKwhlteklekpLPDEKDEDIDVGDIPEpelhkimekyGFADYHGIGD----------II 211
Cdd:cd16147 82 lersTLPVWLQEAGYRTAYAGK----------YLNGYGVPGGVSYVPP----------GWDEWDGLVGnstyynytlsNG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 212 GHSKGGYFYD---STT--TAQTINWLRckgqPLNDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPT 286
Cdd:cd16147 142 GNGKHGVSYPgdyLTDviANKALDFLR----RAAADDKPFFLVVAPPAPH---------------------------GPF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 287 QPPENelYQASWPNYPLPANRHQSFNEQGRPPAHLEYQTARAALEGQFPDED--RRWRKLLDyyfncirdCDTHLDRILN 364
Cdd:cd16147 191 TPAPR--YANLFPNVTAPPRPPPNNPDVSDKPHWLRRLPPLNPTQIAYIDELyrKRLRTLQS--------VDDLVERLVN 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 555243212 365 ELDALKLTDKTIVVFTADHGELGGSHQMH-GKgASVYKEQIHVPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTGLP 441
Cdd:cd16147 261 TLEATGQLDNTYIIYTSDNGYHLGQHRLPpGK-RTPYEEDIRVPLLVRGPGIPAGVTVDQLVSNIDLAPTILDLAGAP 337
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
67-592 |
6.55e-29 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 119.65 E-value: 6.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFPVPGR-----ERLMKTGVTFCNH--QNTsnVCTPSRSVLYTGlhmpqtkmfdnlglpWMPYd 139
Cdd:cd16150 2 NIVIFVADQLRADSLGHLGNPAAvtpnlDALAAEGVRFSNAycQNP--VCSPSRCSFLTG---------------WYPH- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 140 ldpalgTTGH-------------MMREL---GYYTAYKGKWHLTeklekplPDEKDedidvgdipepelhkiMEKYGFAD 203
Cdd:cd16150 64 ------VNGHrtlhhllrpdepnLLKTLkdaGYHVAWAGKNDDL-------PGEFA----------------AEAYCDSD 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 204 YHGIgdiighskggyfydstttAQTINWLRCKGQPlndqhKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntl 283
Cdd:cd16150 115 EACV------------------RTAIDWLRNRRPD-----KPFCLYLPLIFPH--------------------------- 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 284 aptqPPenelYQASWPNY------PLPANRHQSFNEQGRPPA--HLEYQtaraALEGqFPDEdrRWRKLLDYYFNCIRDC 355
Cdd:cd16150 145 ----PP----YGVEEPWFsmidreKLPPRRPPGLRAKGKPSMleGIEKQ----GLDR-WSEE--RWRELRATYLGMVSRL 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 356 DTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHGKGASVYKEQI-HVPMIISHPAYPGNRKCQALTCHLDIAPTL 434
Cdd:cd16150 210 DHQFGRLLEALKETGLYDDTAVFFFSDHGDYTGDYGLVEKWPNTFEDCLtRVPLIIKPPGGPAGGVSDALVELVDIPPTL 289
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 435 VGLTGLPEEKQHQalgnrkGVNFSGLLKNPEGVAVNAVrnaslYCYGMILYTDAHYLhrvialqrDKQKTVAQIKQEISH 514
Cdd:cd16150 290 LDLAGIPLSHTHF------GRSLLPVLAGETEEHRDAV-----FSEGGRLHGEEQAM--------EGGHGPYDLKWPRLL 350
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 555243212 515 LHPDFSHRSGTRMINDGRYKFARyfSLREHNtpetwedlikyndlELYDLKNDPDENHNLAADKQkYQDLILTMNEKL 592
Cdd:cd16150 351 QQEEPPEHTKAVMIRTRRYKYVY--RLYEPD--------------ELYDLEADPLELHNLIGDPA-YAEIIAEMKQRL 411
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
67-590 |
3.01e-28 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 118.25 E-value: 3.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFPVPGR-----ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNlglpwmpydlD 141
Cdd:cd16156 2 QFIFIMTDTQRWDMVGCYGNKAMktpnlDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGSWTN----------C 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 142 PALG----TTGHMMRELGYYTAYKGKWHL--TEKLEKPL-PDEKDED--ID----VGDIPEPELHKIMEKYGFADYHGIg 208
Cdd:cd16156 72 MALGdnvkTIGQRLSDNGIHTAYIGKWHLdgGDYFGNGIcPQGWDPDywYDmrnyLDELTEEERRKSRRGLTSLEAEGI- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 209 diighsKGGYFYDSTTTAQTINWLrckgqplnDQHK--PWFLAVNLVNPHDVMfidtdkegekvqwrgeldqddntLAPt 286
Cdd:cd16156 151 ------KEEFTYGHRCTNRALDFI--------EKHKdeDFFLVVSYDEPHHPF-----------------------LCP- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 287 qPPENELYQaswpNYPLPANRHQSFNEQGRPPAHLEYQTARaalegQFPDEDRRWRKLlDYYFNCIRDCDTHLDRILNEL 366
Cdd:cd16156 193 -KPYASMYK----DFEFPKGENAYDDLENKPLHQRLWAGAK-----PHEDGDKGTIKH-PLYFGCNSFVDYEIGRVLDAA 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 367 DalKLTDKTIVVFTADHGELGGSHQMHGKGASVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLPEEKQ 445
Cdd:cd16156 262 D--EIAEDAWVIYTSDHGDMLGAHKLWAKGPAVYDEITNIPLIIRGKGGeKAGTVTDTPVSHIDLAPTILDYAGIPQPKV 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 446 HQalgnrkGVNFSGLLKNPEGVAVNAVrnaslycygMILYTdahylhrvialqrdkqktvaqiKQEIShlHPDFSHRSGT 525
Cdd:cd16156 340 LE------GESILATIEDPEIPENRGV---------FVEFG----------------------RYEVD--HDGFGGFQPV 380
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 555243212 526 RMINDGRYKFAryfslrehntpetwedLIKYNDLELYDLKNDPDENHNL------AADKQKYQDLILT-MNE 590
Cdd:cd16156 381 RCVVDGRYKLV----------------INLLSTDELYDLEKDPYEMHNLiddpdyADVRDQLHDELLDyMNE 436
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
90-575 |
3.11e-27 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 114.22 E-value: 3.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHL--- 166
Cdd:cd16143 31 DRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRLKGGVLGGFSPPLIEPDRVTLAKMLKQAGYRTAMVGKWHLgld 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 167 -TEKLEKPLPDEKDEDIDV-GDIPEPELHkimekYGFaDYHgIGdiIGHSKggyfYDSTTTAQTINWLrcKGQPLNDqhK 244
Cdd:cd16143 111 wKKKDGKKAATGTGKDVDYsKPIKGGPLD-----HGF-DYY-FG--IPASE----VLPTLTDKAVEFI--DQHAKKD--K 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 245 PWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPTQPPEnelyqaswpnyplpanrhqSFNEQGRPPAHLEYq 324
Cdd:cd16143 174 PFFLYFALPAPH---------------------------TPIVPSP-------------------EFQGKSGAGPYGDF- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 325 taraalegqfpdedrrwrklldyyfncIRDCDTHLDRILNELDALKLTDKTIVVFTADHG----------ELGG---SHQ 391
Cdd:cd16143 207 ---------------------------VYELDWVVGRILDALKELGLAENTLVIFTSDNGpspyadykelEKFGhdpSGP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 392 MHGKGASVYKEQIHVPMIISHPA-YPGNRKCQALTCHLDIAPTLVGLTGLPEEkQHQALgnrKGVNFSGLLKNPEGvavn 470
Cdd:cd16143 260 LRGMKADIYEGGHRVPFIVRWPGkIPAGSVSDQLVSLTDLFATLAAIVGQKLP-DNAAE---DSFSFLPALLGPKK---- 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 471 avrnaslycygmilytdahylhrvialqrdkqktvAQIKQEISHlhpdfSHRSGTRMINDGRYKFARYFSLREHNTPETW 550
Cdd:cd16143 332 -----------------------------------QEVRESLVH-----HSGNGSFAIRKGDWKLIDGTGSGGFSYPRGK 371
|
490 500
....*....|....*....|....*
gi 555243212 551 EDLIKyNDLELYDLKNDPDENHNLA 575
Cdd:cd16143 372 EKLGL-PPGQLYNLSTDPGESNNLY 395
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
91-578 |
1.64e-24 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 106.52 E-value: 1.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPwMPYDLDPALGTTGHMMRELGYYTAYKGKWHL---- 166
Cdd:cd16145 31 RLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRVRGNSEPG-GQDPLPPDDVTLAEVLKKAGYATAAFGKWGLggpg 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 167 TEKLEKPL------------------PDEKDEDIDVGDIPEPELHKIMEKYGFADYHGI--GDIIghskggyfydsttTA 226
Cdd:cd16145 110 TPGHPTKQgfdyfygyldqvhahnyyPEYLWRNGEKVPLPNNVIPPLDEGNNAGGGGGTysHDLF-------------TD 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 227 QTINWLRckgqplNDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPTQPPENELYQASWPNYPLPAN 306
Cdd:cd16145 177 EALDFIR------ENKDKPFFLYLAYTLPH---------------------------APLQVPDDGPYKYKPKDPGIYAY 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 307 RHQSFNEQgrppahleyqtARAALegqfpdedrrwrklldyyfncIRDCDTHLDRILNELDALKLTDKTIVVFTADHG-- 384
Cdd:cd16145 224 LPWPQPEK-----------AYAAM---------------------VTRLDRDVGRILALLKELGIDENTLVVFTSDNGph 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 385 -ELGGSHQ---------MHGKGASVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnrk 453
Cdd:cd16145 272 sEGGSEHDpdffdsngpLRGYKRSLYEGGIRVPFIARWPGKiPAGSVSDHPSAFWDFMPTLADLAGAEPPEDID------ 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 454 GVNFSGLLKNpegvavnavrnaslycygmilytdahylhrvialQRDKQKTvaqikqeiSHLHPDFSHRSGTRMINDGRY 533
Cdd:cd16145 346 GISLLPTLLG----------------------------------KPQQQQH--------DYLYWEFYEGGGAQAVRMGGW 383
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 555243212 534 KfaryfsLREHNTPEtwedlikyNDLELYDLKNDPDENHNLAADK 578
Cdd:cd16145 384 K------AVRHGKKD--------GPFELYDLSTDPGETNNLAAQH 414
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
67-440 |
1.84e-24 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 104.04 E-value: 1.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFPVPGR-----ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLglPWMPYDLD 141
Cdd:pfam00884 2 NVVLVLGESLRAPDLGLYGYPRPttpflDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVST--PVGLPRTE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 142 PALGTtghMMRELGYYTAYKGKWHLTEKLEKPLPDEKDEDIdVGDIPEPELHKIMEKYGFadyhgigdiigHSKGGYFYD 221
Cdd:pfam00884 80 PSLPD---LLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKF-FGRNTGSDLYADPPDVPY-----------NCSGGGVSD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 222 STTTAQTINWLrckgqplNDQHKPWFLAVNLVNPHDvmfidtdkegekvqwrgeldqddntlaptqppenelyqaswpny 301
Cdd:pfam00884 145 EALLDEALEFL-------DNNDKPFFLVLHTLGSHG-------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 302 PLPANRhqsfneqgrppahlEYQTARAALEGQFPDEDRrwrkLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTA 381
Cdd:pfam00884 174 PPYYPD--------------RYPEKYATFKPSSCSEEQ----LLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTS 235
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 555243212 382 DHGEL---GGSHQMHGKGASVYKEQIHVPMII-SHPAYPGNRKCQALTCHLDIAPTLVGLTGL 440
Cdd:pfam00884 236 DHGESlgeGGGYLHGGKYDNAPEGGYRVPLLIwSPGGKAKGQKSEALVSHVDLFPTILDLAGI 298
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
90-439 |
2.26e-24 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 104.20 E-value: 2.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTF----CNhqntSNVCTPSRSVLYTGLHMPQTKMFDNLGlpwmpyDLDPALGTTGHMMRELGYYTAYKGKWH 165
Cdd:cd16032 30 DRLAARGVVFdnayCN----SPLCAPSRASMMTGRLPSRIGAYDNAA------EFPADIPTFAHYLRAAGYRTALSGKMH 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 166 LteklekplpdekdedidVGdiPEpELHkimekygfadyhgigdiighskgGYFYDSTTTAQTINWLRCKGQPLNDQhkP 245
Cdd:cd16032 100 F-----------------VG--PD-QLH-----------------------GFDYDEEVAFKAVQKLYDLARGEDGR--P 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 246 WFLAVNLVNPHDvmfidtdkegekvqwrgeldqddntlaPTQPPenelyQASWPNYplpanrhqsfneqgrppahleYQT 325
Cdd:cd16032 135 FFLTVSFTHPHD---------------------------PYVIP-----QEYWDLY---------------------VRR 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 326 ARAAlegqfpdedrrwrklldyYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHGKgASVYKEQIH 405
Cdd:cd16032 162 ARRA------------------YYGMVSYVDDKVGQLLDTLERTGLADDTIVIFTSDHGDMLGERGLWYK-MSFFEGSAR 222
|
330 340 350
....*....|....*....|....*....|....
gi 555243212 406 VPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTG 439
Cdd:cd16032 223 VPLIISAPGRFAPRRVAEPVSLVDLLPTLVDLAG 256
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
91-575 |
6.02e-24 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 104.57 E-value: 6.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHLtekl 170
Cdd:cd16026 32 RLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGLPGVVGPPGSKGGLPPDEITIAEVLKKAGYRTALVGKWHL---- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 171 ekplpdekdedidvGDipEPELHKImeKYGFADYHGIgdiighskggyfydstttaqtinwlrckgqPLNDQHKPWflaV 250
Cdd:cd16026 108 --------------GH--QPEFLPT--RHGFDEYFGI------------------------------PYSNDMWPF---P 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 251 NLVNPHDVMFIDTDKEGEKVQWrgELDQDDNTLAPTQPP-----ENE-----LYQA-SWPNYPLpanrhqsfneqgrppa 319
Cdd:cd16026 137 LYRNDPPGPLPPLMENEEVIEQ--PADQSSLTQRYTDEAvdfieRNKdqpffLYLAhTMPHVPL---------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 320 hleyqtaraalegqFPDEDRRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHG------ELGGSHQM- 392
Cdd:cd16026 199 --------------FASEKFKGRSGAGLYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDNGpwleygGHGGSAGPl 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 393 HGKGASVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTG--LPEEkqhqalgnRK--GVNFSGLLKNPEgv 467
Cdd:cd16026 265 RGGKGTTWEGGVRVPFIAWWPGViPAGTVSDELASTMDLLPTLAALAGapLPED--------RVidGKDISPLLLGGS-- 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 468 avNAVRNASLYcygmilYTDAHYLHRVIalqrdkqktvaqikqeishlhpdfshrsgtrminDGRYKfARYFSLREHNTP 547
Cdd:cd16026 335 --KSPPHPFFY------YYDGGDLQAVR----------------------------------SGRWK-LHLPTTYRTGTD 371
|
490 500
....*....|....*....|....*...
gi 555243212 548 ETWEDLIKYNDLELYDLKNDPDENHNLA 575
Cdd:cd16026 372 PGGLDPTKLEPPLLYDLEEDPGETYNVA 399
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
90-577 |
1.10e-21 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 97.62 E-value: 1.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFcNHQNTSNVCTPSRSVLYTGLHMPQTKMFD-NLGLpwmpYDLDPALGTTGHMMRELGYYTAYKGKWHLte 168
Cdd:cd16146 30 DRLAAESVRF-TNFHVSPVCAPTRAALLTGRYPFRTGVWHtILGR----ERMRLDETTLAEVFKDAGYRTGIFGKWHL-- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 169 klekplpdekdedidvGDIP--EPELHKIMEKYGFADYHgIGDIIGHSKGGYFYDSTT----------------TAQTIN 230
Cdd:cd16146 103 ----------------GDNYpyRPQDRGFDEVLGHGGGG-IGQYPDYWGNDYFDDTYYhngkfvktegyctdvfFDEAID 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 231 WLRckgqplNDQHKPWF--LAVNLvnPHdvmfidtdkegekvqwrgeldqddntlAPTQPPENELYQaswpnyplpanrh 308
Cdd:cd16146 166 FIE------ENKDKPFFayLATNA--PH---------------------------GPLQVPDKYLDP------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 309 qsFNEQGRPPAHleyqtarAAlegqfpdedrrwrklldyYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGG 388
Cdd:cd16146 198 --YKDMGLDDKL-------AA------------------FYGMIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGG 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 389 SHQ-----MHGKGASVYKEQIHVPMIISHPA-YPGNRKCQALTCHLDIAPTLVGLTGLPEekqhQALGNRKGVNFSGLLK 462
Cdd:cd16146 251 VPKrfnagMRGKKGSVYEGGHRVPFFIRWPGkILAGKDVDTLTAHIDLLPTLLDLCGVKL----PEGIKLDGRSLLPLLK 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 463 NPEgvavNAVRNASLYcygmilytdAHYlHRVIALQRDKQKTVaqikqeishlhpdfshrsgtrmINDGRYKFaryfsLR 542
Cdd:cd16146 327 GES----DPWPERTLF---------THS-GRWPPPPKKKRNAA----------------------VRTGRWRL-----VS 365
|
490 500 510
....*....|....*....|....*....|....*
gi 555243212 543 EHNTPetwedlikyndLELYDLKNDPDENHNLAAD 577
Cdd:cd16146 366 PKGFQ-----------PELYDIENDPGEENDVADE 389
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
67-609 |
4.63e-20 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 93.58 E-value: 4.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQERFFPTFPFPVPGRE-----RLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFD-NLGLPWM-PYD 139
Cdd:PRK13759 8 NIILIMVDQMRGDCLGCNGNKAVEtpnldMLASEGYNFENAYSAVPSCTPARAALLTGLSQWHHGRVGyGDVVPWNyKNT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 140 LdpalgttGHMMRELGYYTAYKGKWH--------------LTEKLEKPLPDEKDEDIDVGDIPEPELhKIMEKYGFADYH 205
Cdd:PRK13759 88 L-------PQEFRDAGYYTQCIGKMHvfpqrnllgfhnvlLHDGYLHSGRNEDKSQFDFVSDYLAWL-REKAPGKDPDLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 206 GIGdIIGHSKGGYFYD-------STTTAQT-INWLRCKgqplnDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeld 277
Cdd:PRK13759 160 DIG-WDCNSWVARPWDleerlhpTNWVGSEsIEFLRRR-----DPTKPFFLKMSFARPH--------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 278 qddntlAPTQPPEN--ELYQ-ASWPNyPLPANRHQSFNEQGRppahleyQTARAALEGQFPDED-RRWRKlldYYFNCIR 353
Cdd:PRK13759 213 ------SPYDPPKRyfDMYKdADIPD-PHIGDWEYAEDQDPE-------GGSIDALRGNLGEEYaRRARA---AYYGLIT 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 354 DCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHGKGASvYKEQIHVPMIISHPAYPGNRKCQALTCHL----D 429
Cdd:PRK13759 276 HIDHQIGRFLQALKEFGLLDNTIILFVSDHGDMLGDHYLFRKGYP-YEGSAHIPFIIYDPGGLLAGNRGTVIDQVvelrD 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 430 IAPTLVGLTGL--PEEKQHQALGNrkgvnfsgLLKNPEgvavNAVRNaslycygmilytdahYLHrvialqrdkqktvaq 507
Cdd:PRK13759 355 IMPTLLDLAGGtiPDDVDGRSLKN--------LIFGQY----EGWRP---------------YLH--------------- 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 508 ikqeISHlhpdFSHRSGTRMINDGRYKFARYFslreHNTPEtwedlikyndlELYDLKNDPDENHNLAADKqKYQDLILT 587
Cdd:PRK13759 393 ----GEH----ALGYSSDNYLTDGKWKYIWFS----QTGEE-----------QLFDLKKDPHELHNLSPSE-KYQPRLRE 448
|
570 580
....*....|....*....|....
gi 555243212 588 MNEKLNKIIKD--EIGVDDGSFMP 609
Cdd:PRK13759 449 MRKKLVDHLRGreEGFVKDGKLVV 472
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
67-441 |
1.01e-19 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 89.22 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTD-QERFFPTFPFPVPGR----ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLhMP-QTKMFD-----NLGLPW 135
Cdd:cd16149 2 NILFILTDdQGPWALGCYGNSEAVtpnlDRLAAEGVRFENFFCTSPVCSPARASLLTGR-MPsQHGIHDwivegSHGKTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 136 MPYDLDPALGTTGHMMRELGYYTAYKGKWHLTEKLEKPLPDEKDEDidvgdipepelhkimekygfadyhgigdiighsk 215
Cdd:cd16149 81 KPEGYLEGQTTLPEVLQDAGYRCGLSGKWHLGDDAADFLRRRAEAE---------------------------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 216 ggyfydstttaqtinwlrckgqplndqhKPWFLAVNLVNPHDvmfidtdkegekvQWRgeldqddntlaptqppenelyq 295
Cdd:cd16149 127 ----------------------------KPFFLSVNYTAPHS-------------PWG---------------------- 143
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 296 aswpnyplpanrhqsfneqgrppahleyqtaraalegqfpdedrrwrklldyYFNCIRDCDTHLDRILNELDALKLTDKT 375
Cdd:cd16149 144 ----------------------------------------------------YFAAVTGVDRNVGRLLDELEELGLTENT 171
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 555243212 376 IVVFTADHGELGGSHQMHGKG-----ASVYKEQIHVPMIISHP-AYPGNRKCQALTCHLDIAPTLVGLTGLP 441
Cdd:cd16149 172 LVIFTSDNGFNMGHHGIWGKGngtfpLNMYDNSVKVPFIIRWPgVVPAGRVVDSLVSAYDFFPTLLELAGVD 243
|
|
| YejM |
COG3083 |
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ... |
221-434 |
6.08e-18 |
|
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];
Pssm-ID: 442317 [Multi-domain] Cd Length: 603 Bit Score: 87.65 E-value: 6.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 221 DSTTTAQTINWLrcKGQplnDQHKPWFLAVNLVNPHDvmfidtdkegekvqwrgeLDQDDNTLAPTQPPENelyqaswpn 300
Cdd:COG3083 363 DRQITAQWLQWL--DQR---DSDRPWFSYLFLDAPHA------------------YSFPADYPKPFQPSED--------- 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 301 yplpANRHQSFNEQGRPPahleyqtaraalegqfpdedrrwrkLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFT 380
Cdd:COG3083 411 ----CNYLALDNESDPTP-------------------------FKNRYRNAVHYVDSQIGRVLDTLEQRGLLENTIVIIT 461
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 555243212 381 ADHG-ELGGSHQMHGKGASVY-KEQIHVPMIIShpaYPGN--RKCQALTCHLDIAPTL 434
Cdd:COG3083 462 ADHGeEFNENGQNYWGHNSNFsRYQLQVPLVIH---WPGTppQVISKLTSHLDIVPTL 516
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
91-462 |
4.23e-16 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 80.27 E-value: 4.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTF--CNHQNTsnvCTPSRSVLYTGLHMPQTKMFdNLGLPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHLte 168
Cdd:cd16142 34 RLAKEGLRFtsFYVEPS---CTPGRAAFITGRHPIRTGLT-TVGLPGSPGGLPPWEPTLAELLKDAGYATAQFGKWHL-- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 169 klekplpdekdedidvGDIPE--PELHkimekyGFADYHGIgdiighskGGYFYDSTTTAQTINWLRckgqplnDQH--- 243
Cdd:cd16142 108 ----------------GDEDGrlPTDH------GFDEFYGN--------LYHTIDEEIVDKAIDFIK-------RNAkad 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 244 KPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlaptqppenelyqasWPNYPLPANRHQSfneqgrppahley 323
Cdd:cd16142 151 KPFFLYVNFTKMH-----------------------------------------FPTLPSPEFEGKS------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 324 qTARaaleGQFPDedrrwrklldyyfnCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGE------LGGSHQMHGKGA 397
Cdd:cd16142 177 -SGK----GKYAD--------------SMVELDDHVGQILDALDELGIADNTIVIFTTDNGPeqdvwpDGGYTPFRGEKG 237
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 555243212 398 SVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQALGNRK--GVNFSGLLK 462
Cdd:cd16142 238 TTWEGGVRVPAIVRWPGKiKPGRVSNEIVSHLDWFPTLAALAGAPDPKDKLLGKDRHidGVDQSPFLL 305
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
67-441 |
2.07e-14 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 73.95 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 67 NILLVVTDQER---------FFPTFPFPVPGR------ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNl 131
Cdd:cd16153 3 NILWIITDDQRvdslscynnAHTGKSESRLGYvespniDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVYGF- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 132 glPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHLTEklekplpdekdedidvgdipepelhkimekygFADYhgigdii 211
Cdd:cd16153 82 --EAAHPALDHGLPTFPEVLKKAGYQTASFGKSHLEA--------------------------------FQRY------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 212 ghskggyfYDSTTTAQTINWLRCKGQPlnDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPTQPPEn 291
Cdd:cd16153 121 --------LKNANQSYKSFWGKIAKGA--DSDKPFFVRLSFLQPH---------------------------TPVLPPK- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 292 elyqaswpnyplpanrhqsfneqgrppahleyqtaraalegqfpdedrRWRKLLDYYFNCirdcdTHLD----RILNELD 367
Cdd:cd16153 163 ------------------------------------------------EFRDRFDYYAFC-----AYGDaqvgRAVEAFK 189
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 368 ALKLT---DKTIVVFTADHGELGGSHQMHGKgASVYKEQIHVPMIISHP---AYPGNRKCQALTCHLDIAPTLVGLTGLP 441
Cdd:cd16153 190 AYSLKqdrDYTIVYVTGDHGWHLGEQGILAK-FTFWPQSHRVPLIVVSSdklKAPAGKVRHDFVEFVDLAPTLLAAAGVD 268
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
91-574 |
4.68e-14 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 74.40 E-value: 4.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSnVCTPSRSVLYTGLHMPQTkmfdnlGLPWMPYDLDPALGTTGH----------MMRELGYYTAY 160
Cdd:cd16025 32 ALAAEGLRFTNFHTTA-LCSPTRAALLTGRNHHQV------GMGTMAELATGKPGYEGYlpdsaatiaeVLKDAGYHTYM 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 161 KGKWHLteklekplpdekdedidvgdipepelhkimekyGFADYHgigdiighskggyfydSTT--TAQTINWLRcKGQp 238
Cdd:cd16025 105 SGKWHL---------------------------------GPDDYY----------------STDdlTDKAIEYID-EQK- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 239 lnDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlAPTQPPENEL------YQASWPNypLPANRHQSFN 312
Cdd:cd16025 134 --APDKPFFLYLAFGAPH---------------------------APLQAPKEWIdkykgkYDAGWDA--LREERLERQK 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 313 EQGRPPAHLEYqTARAALE---GQFPDEDRRW--RK------LLDYyfncirdCDTHLDRILNELDALKLTDKTIVVFTA 381
Cdd:cd16025 183 ELGLIPADTKL-TPRPPGVpawDSLSPEEKKLeaRRmevyaaMVEH-------MDQQIGRLIDYLKELGELDNTLIIFLS 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 382 DHG---ELG----GS-------HQMHGKGasvykeqIHVPMIISHPAY--PGNRKCQALTcHL-DIAPTLVGLTGLPEEK 444
Cdd:cd16025 255 DNGasaEPGwanaSNtpfrlykQASHEGG-------IRTPLIVSWPKGikAKGGIRHQFA-HViDIAPTILELAGVEYPK 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 445 QHqalgnrkgvnfsgllknpEGVAVNAVRNASLycygmiLYT----DAHYLHRVIAlqrdkqktvaqikqeishlhpdFS 520
Cdd:cd16025 327 TV------------------NGVPQLPLDGVSL------LPTldgaAAPSRRRTQY----------------------FE 360
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 555243212 521 HrSGTRMINDGRYKfaryfsLREHNTPETWEDlikynDLELYDLKNDPDENHNL 574
Cdd:cd16025 361 L-FGNRAIRKGGWK------AVALHPPPGWGD-----QWELYDLAKDPSETHDL 402
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
334-447 |
1.28e-13 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 73.92 E-value: 1.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 334 FPDEDRRW----RKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHqmhgKGASVYKEQIHVPMI 409
Cdd:COG1368 401 LPEEDKKIpdygKTTLNNYLNAVRYADQALGEFIEKLKKSGWYDNTIFVIYGDHGPRSPGK----TDYENPLERYRVPLL 476
|
90 100 110
....*....|....*....|....*....|....*...
gi 555243212 410 ISHPAYPGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQ 447
Cdd:COG1368 477 IYSPGLKKPKVIDTVGSQIDIAPTLLDLLGIDYPSYYA 514
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
93-441 |
5.33e-13 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 70.65 E-value: 5.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 93 MKT-GVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGlpwmpyDLDPALGTTGHMMRELGYYTAYKGK-------- 163
Cdd:cd16171 32 MKQhGSVFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNYK------GLDPNYPTWMDRLEKHGYHTQKYGKldytsghh 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 164 --------WhlTEKLEKPLPDEKDEDID-VGDIPEPelhKIMEKygfadyhgigdiighskggyfyDSTTTAQTINWLRC 234
Cdd:cd16171 106 svsnrveaW--TRDVPFLLRQEGRPTVNlVGDRSTV---RVMLK----------------------DWQNTDKAVHWIRK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 235 KGQplnDQHKPWFLAVNLVNPHDvmfidtdkegekvqwrgeldqddntlaptqppenelyqaswpnYPLPAnrhqsfneQ 314
Cdd:cd16171 159 EAP---NLTQPFALYLGLNLPHP-------------------------------------------YPSPS--------M 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 315 GRPPAHLeyqtaraalegqfpdedrrwRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHG 394
Cdd:cd16171 185 GENFGSI--------------------RNIRAFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHGELAMEHRQFY 244
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 555243212 395 KgASVYKEQIHVPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTGLP 441
Cdd:cd16171 245 K-MSMYEGSSHVPLLIMGPGIKAGQQVSDVVSLVDIYPTMLDIAGVP 290
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
90-580 |
1.30e-12 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 70.15 E-value: 1.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLG--LPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHLT 167
Cdd:cd16160 31 DDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMYGGTRvfLPWDIGGLPKTEVTMAEALKEAGYTTGMVGKWHLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 168 EKLEKP-----LPDEKDEDIdVGDIPEPELHKimekygFADYHGIGDIIGHSKGGYFYDSTT-TAQTINWLRCKGQPLND 241
Cdd:cd16160 111 INENNHsdgahLPSHHGFDF-VGTNLPFTNSW------ACDDTGRHVDFPDRSACFLYYNDTiVEQPIQHEHLTETLVGD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 242 --------QHKPWFLAVNLVNPHDVMFIDTDKEGEKVqwRGELdqDDNTlaptqppeNELyqaSWpnyplpanrhqsfne 313
Cdd:cd16160 184 aksfiednQENPFFLYFSFPQTHTPLFASKRFKGKSK--RGRY--GDNI--------NEM---SW--------------- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 314 qgrppahleyqtaraALEgqfpdedrrwrklldyyfncirdcdthldRILNELDALKLTDKTIVVFTADHG------ELG 387
Cdd:cd16160 234 ---------------AVG-----------------------------EVLDTLVDTGLDQNTLVFFLSDHGphveycLEG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 388 GSHQMH--GKGASvYKEQIHVPMIISHPAYPGNRKCQALTCHLDIAPTLVGLTG--LPEEkqhqalGNRKGVNFSGLLKn 463
Cdd:cd16160 270 GSTGGLkgGKGNS-WEGGIRVPFIAYWPGTIKPRVSHEVVSTMDIFPTFVDLAGgtLPTD------RIYDGLSITDLLL- 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 464 peGVAVNAVRNaslycygmILYtdaHYLHRVIALQRDKQKTvaqikqeisHLHpdfSHRSGTRMINDGRykfARYFSLRE 543
Cdd:cd16160 342 --GEADSPHDD--------ILY---YCCSRLMAVRYGSYKI---------HFK---TQPLPSQESLDPN---CDGGGPLS 393
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 555243212 544 HNTpeTWED-----LIKYNDLELYDLKNDPDENHNLAADKQK 580
Cdd:cd16160 394 DYI--VCYDcedecVTKHNPPLIFDVEKDPGEQYPLQPSVYE 433
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
343-439 |
2.74e-12 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 67.71 E-value: 2.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 343 KLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMhgKGASVYKEQIHVPMIISHPAYPGNRKCQ 422
Cdd:cd16015 189 TELENYLNAIHYTDKALGEFIEKLKKSGLYENTIIVIYGDHLPSLGSDYD--ETDEDPLDLYRTPLLIYSPGLKKPKKID 266
|
90
....*....|....*..
gi 555243212 423 ALTCHLDIAPTLVGLTG 439
Cdd:cd16015 267 RVGSQIDIAPTLLDLLG 283
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
91-411 |
5.04e-12 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 67.76 E-value: 5.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQNTSnVCTPSRSVLYTGLHMPQTkmfdnlGLPWMPydlDPALGTTGHMMREL-------GYYTAYKGK 163
Cdd:cd16154 33 SLANSGIVFDNLWATP-ACSPTRATILTGKYGFRT------GVLAVP---DELLLSEETLLQLLikdattaGYSSAVIGK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 164 WHLTeklekplpdekdedidvGDIPEPelhkiMEKYGFADYHGIgdIIGHSKGGYFYDSTTTAQT--------------- 228
Cdd:cd16154 103 WHLG-----------------GNDNSP-----NNPGGIPYYAGI--LGGGVQDYYNWNLTNNGQTtnsteyattkltnla 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 229 INWLrckgqplNDQHKPWFLavnlvnphdvmfidtdkegekvqWrgeldqddntLAptqppenelYQAswPNYPLPAnrh 308
Cdd:cd16154 159 IDWI-------DQQTKPWFL-----------------------W----------LA---------YNA--PHTPFHL--- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 309 qsfneqgrPPAHLEYQTaraaLEGQFPDEDRRWRkllDYYFNCIRDCDTHLDRILNELDALKLtDKTIVVFTADHGELGG 388
Cdd:cd16154 185 --------PPAELHSRS----LLGDSADIEANPR---PYYLAAIEAMDTEIGRLLASIDEEER-ENTIIIFIGDNGTPGQ 248
|
330 340
....*....|....*....|....*...
gi 555243212 389 SHQM-----HGKGaSVYKEQIHVPMIIS 411
Cdd:cd16154 249 VVDLpytrnHAKG-SLYEGGINVPLIVS 275
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
361-590 |
9.89e-11 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 64.62 E-value: 9.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 361 RILNELDALKLTDKTIVVFTADHG---ELGGSHQMH---------GKGASVYKEQIHVPMIISHPAY-PGNRKCQALTCH 427
Cdd:cd16159 294 QILDALDELGLKDNTFVYFTSDNGghlEEISVGGEYgggnggiygGKKMGGWEGGIRVPTIVRWPGViPPGSVIDEPTSL 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 428 LDIAPTLVGLTG--LPEEKQHQalgnrkGVNFSGLLKNPEgvavnavrNASLYCYgMILYTDAHyLHRVialqrdkqktv 505
Cdd:cd16159 374 MDIFPTVAALAGapLPSDRIID------GRDLMPLLTGQE--------KRSPHEF-LFHYCGAE-LHAV----------- 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 506 aqikqeisHLHPdfshRSGTRMindgrYKfARYFSLREHNTPETW----------EDLIKYNDLELYDLKNDPDENHNLA 575
Cdd:cd16159 427 --------RYRP----RDGGAV-----WK-AHYFTPNFYPGTEGCcgtllcrcfgDSVTHHDPPLLFDLSADPSESNPLD 488
|
250
....*....|....*
gi 555243212 576 ADKQKYQDLILTMNE 590
Cdd:cd16159 489 PTDEPYQEIIKKILE 503
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
91-574 |
2.53e-10 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 62.62 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFcNHQNTSNVCTPSRSVLYTGLHMpqtkmFDNLglpWMPYDLDPALGTTGHMMRELGYYTAYKGKWHLT-EK 169
Cdd:cd16151 31 ALAAEGVRF-NNAYAQPLCTPSRVQLMTGKYN-----FRNY---VVFGYLDPKQKTFGHLLKDAGYATAIAGKWQLGgGR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 170 LEKPLPdekdedidvgdipepelhkimEKYGFADY---HGIGDIIGHSKGGYFY-------DSTTTAQT----------I 229
Cdd:cd16151 102 GDGDYP---------------------HEFGFDEYclwQLTETGEKYSRPATPTfnirngkLLETTEGDygpdlfadflI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 230 NWLRckgqplNDQHKPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlaptqppenelyqasWPNYPLPANRHQ 309
Cdd:cd16151 161 DFIE------RNKDQPFFAYYPMVLVH-----------------------------------------DPFVPTPDSPDW 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 310 SfneqgrppahleyqtaraalegqfpDEDRRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHG-ELGG 388
Cdd:cd16151 194 D-------------------------PDDKRKKDDPEYFPDMVAYMDKLVGKLVDKLEELGLRENTIIIFTGDNGtHRPI 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 389 SHQMHGKGASVYKEQ-----IHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTGLPEEKQHQalgnRKGVNFSGLLK 462
Cdd:cd16151 249 TSRTNGREVRGGKGKttdagTHVPLIVNWPGLiPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYP----LDGRSFAPQLL 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 463 NPEGvavnAVRNASLYCYGmilytdahylhrvialqrdkqktvaqikqeishlhPDFSHRSGTRMINDGRYKFaryfslr 542
Cdd:cd16151 325 GKTG----SPRREWIYWYY-----------------------------------RNPHKKFGSRFVRTKRYKL------- 358
|
490 500 510
....*....|....*....|....*....|..
gi 555243212 543 ehntpetwedlikYNDLELYDLKNDPDENHNL 574
Cdd:cd16151 359 -------------YADGRFFDLREDPLEKNPL 377
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
348-437 |
1.55e-08 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 55.89 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 348 YFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHqmHGKGASVYKE-----QIHVPMIISHPAYPGNRKCQ 422
Cdd:cd00016 144 YYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGIDKGH--GGDPKADGKAdkshtGMRVPFIAYGPGVKKGGVKH 221
|
90
....*....|....*
gi 555243212 423 ALTCHLDIAPTLVGL 437
Cdd:cd00016 222 ELISQYDIAPTLADL 236
|
|
| DUF4976 |
pfam16347 |
Domain of unknown function (DUF4976); This family consists of uncharacterized proteins around ... |
528-598 |
4.94e-08 |
|
Domain of unknown function (DUF4976); This family consists of uncharacterized proteins around 530 residues in length and is mainly found in various Bacteroides species. Several proteins in this family are annotated as Arylsulfatases, but the function of this protein is unknown.
Pssm-ID: 406689 [Multi-domain] Cd Length: 103 Bit Score: 51.10 E-value: 4.94e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555243212 528 INDGRYKFARYFslrehNTPETWEdlikyndleLYDLKNDPDENHNLAADKQkYQDLILTMNEKLNKIIKD 598
Cdd:pfam16347 45 VRTERYKLIHFY-----NDIDEWE---------LYDLQKDPKEMNNVYGDPE-YAEVQAELKEELEELRKQ 100
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
90-574 |
2.86e-07 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 53.22 E-value: 2.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHLTEK 169
Cdd:cd16158 31 DRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGVFYPGSRGGLPLNETTIAEVLKTVGYQTAMVGKWHLGVG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 170 LE-KPLPdekdedidvgdipepelhkimEKYGFADYHGIgdiighskggyfydstttaqtinwlrckgqPLNDQHKPwfl 248
Cdd:cd16158 111 LNgTYLP---------------------THQGFDHYLGI------------------------------PYSHDQGP--- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 249 AVNLVN-PHDVMFIDTDKEGE---KVQWRGELDQddntlaptQPPE----NELYQASwpnyplpANRHQSFNEQGRPPAH 320
Cdd:cd16158 137 CQNLTCfPPNIPCFGGCDQGEvpcPLFYNESIVQ--------QPVDlltlEERYAKF-------AKDFIADNAKEGKPFF 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 321 LEYQTARAALEgQFPDEDRRWRKLLDYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHG------ELGGSHQMH- 393
Cdd:cd16158 202 LYYASHHTHYP-QFAGQKFAGRSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGpstmrkSRGGNAGLLk 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 394 -GKGaSVYKEQIHVPMIISHPAY--PGnrKCQALTCHLDIAPTLVGLTG--LPEekqhQALgnrKGVNFSGLLKNPEgva 468
Cdd:cd16158 281 cGKG-TTYEGGVREPAIAYWPGRikPG--VTHELASTLDILPTIAKLAGapLPN----VTL---DGVDMSPILFEQG--- 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 469 vNAVRNASLYcygmiLYTDAHYLHRVIALQRDKQKtvaqikqeiSHLHPDFSHRSGTRMINDGRYKfaryFSLREHNTPe 548
Cdd:cd16158 348 -KSPRQTFFY-----YPTSPDPDKGVFAVRWGKYK---------AHFYTQGAAHSGTTPDKDCHPS----AELTSHDPP- 407
|
490 500
....*....|....*....|....*.
gi 555243212 549 twedlikyndlELYDLKNDPDENHNL 574
Cdd:cd16158 408 -----------LLFDLSQDPSENYNL 422
|
|
| LptA |
cd16017 |
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ... |
342-440 |
4.51e-07 |
|
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.
Pssm-ID: 293741 [Multi-domain] Cd Length: 288 Bit Score: 51.86 E-value: 4.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 342 RKLLDYYFNCIRdcdtHLDRILNEL-DALKLTDK-TIVVFTADHGE-LGGS-HQMHGKGASVyKEQIHVPMII-----SH 412
Cdd:cd16017 182 EELINAYDNSIL----YTDYVLSQIiERLKKKDKdAALIYFSDHGEsLGENgLYLHGAPYAP-KEQYHVPFIIwssdsYK 256
|
90 100 110
....*....|....*....|....*....|..
gi 555243212 413 PAYPGNR----KCQALTcHLDIAPTLVGLTGL 440
Cdd:cd16017 257 QRYPVERlranKDRPFS-HDNLFHTLLGLLGI 287
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
90-461 |
1.31e-06 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 50.93 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 90 ERLMKTGVTFCNHQNTSNVCTPSRSVLYTGLHMPQTKMFDNL------GLPwmpydLDPAlgTTGHMMRELGYYTAYKGK 163
Cdd:cd16161 32 DKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFlptsvgGLP-----LNET--TLAEVLRQAGYATGMIGK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 164 WHLTEKlEKPLPDEKdedidvgdipepelhkimekyGFADYHGIGdiighskggYFYDSTTTAQTINWLRCKGQPLNDQH 243
Cdd:cd16161 105 WHLGQR-EAYLPNSR---------------------GFDYYFGIP---------FSHDSSLADRYAQFATDFIQRASAKD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 244 KPWFLAVNLVNPHdvmfidtdkegekvqwrgeldqddntlaptqppenelyqASWPNYPLPANrhqsfNEQGRPPahley 323
Cdd:cd16161 154 RPFFLYAALAHVH---------------------------------------VPLANLPRFQS-----PTSGRGP----- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 324 qtaraalegqfpdedrrwrklldyYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHG------ELGGSH---QMHG 394
Cdd:cd16161 185 ------------------------YGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGpwevkcELAVGPgtgDWQG 240
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555243212 395 KG------ASVYKEQIHVPMIISHPAY-PGNRKCQALTCHLDIAPTLVGLTG--LPEEKQHQalgnrkGVNFSGLL 461
Cdd:cd16161 241 NLggsvakASTWEGGHREPAIVYWPGRiPANSTSAALVSTLDIFPTVVALAGasLPPGRIYD------GKDLSPVL 310
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
91-439 |
5.85e-06 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 49.09 E-value: 5.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 91 RLMKTGVTFCNHQnTSNVCTPSRSVLYTGLHMPQTKMFDNLGLPWMPYDLDPALGTTGHMMRELGYYTAYKGKWHL---T 167
Cdd:cd16029 31 ALAADGVILNNYY-VQPICTPSRAALMTGRYPIHTGMQHGVILAGEPYGLPLNETLLPQYLKELGYATHLVGKWHLgfyT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 168 EKLekpLPDEKdedidvgdipepelhkimekyGFaDYHgigdiIGHSKGGYFYDSTTTAQTINW----LRCKGQPLNDQH 243
Cdd:cd16029 110 WEY---TPTNR---------------------GF-DSF-----YGYYGGAEDYYTHTSGGANDYgnddLRDNEEPAWDYN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 244 KPW--FL----AVNLVNPHDV---MFIdtdkegekvqwrgeldqddnTLAptqppenelYQAswPNYPLPAnrhqsfneq 314
Cdd:cd16029 160 GTYstDLftdrAVDIIENHDPskpLFL--------------------YLA---------FQA--VHAPLQV--------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 315 grPPahlEYQTARAALEGQFPDEDRRwrklldYYFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGelGGSHQMHG 394
Cdd:cd16029 200 --PP---EYADPYEDKFAHIKDEDRR------TYAAMVSALDESVGNVVDALKAKGMLDNTLIVFTSDNG--GPTGGGDG 266
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 555243212 395 ------KG--ASVYKEQIHVPMIISHPAYPGNR--KCQALTCHLDIAPTLVGLTG 439
Cdd:cd16029 267 gsnyplRGgkNTLWEGGVRVPAFVWSPLLPPKRgtVSDGLMHVTDWLPTLLSLAG 321
|
|
| OpgE |
COG2194 |
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ... |
348-410 |
7.37e-05 |
|
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441797 [Multi-domain] Cd Length: 537 Bit Score: 45.62 E-value: 7.37e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 555243212 348 YFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHGELGGSHQMHGKGASvY----KEQIHVPMII 410
Cdd:COG2194 414 YDNTILYTDYVLSQVIDLLKAKQDRYDTAMLYVSDHGESLGENGLYLHGTP-YaiapDEQTHVPMIM 479
|
|
| GPI_EPT_2 |
cd16024 |
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ... |
361-441 |
2.04e-04 |
|
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293748 [Multi-domain] Cd Length: 274 Bit Score: 43.71 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 361 RILNELDALKLTDKTIVVFTADHG--ELGGshqmHGkGASvyKEQIHVPMIISHPAY-PGNRKCQALTCHL------DIA 431
Cdd:cd16024 182 RIYESLEEQSSNNPTLLVVCGDHGmtDAGN----HG-GSS--PGETSVPLLFISPKFsSKPSNADGELSYYetvqqvDLA 254
|
90
....*....|
gi 555243212 432 PTLVGLTGLP 441
Cdd:cd16024 255 PTLALLLGLP 264
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
352-439 |
5.43e-04 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 42.19 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555243212 352 IRDCDTHLDRILNELDALKLTDKTIVVFTADHGELG-GSHqmhgkGASVYKEQIHVPMIISHPAYPGNRKCQalTCHL-D 429
Cdd:cd16018 185 LKRVDRRLGYLIEALKERGLLDDTNIIVVSDHGMTDvGTH-----GYDNELPDMRAIFIARGPAFKKGKKLG--PFRNvD 257
|
90
....*....|
gi 555243212 430 IAPTLVGLTG 439
Cdd:cd16018 258 IYPLMCNLLG 267
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
348-384 |
8.12e-04 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 42.04 E-value: 8.12e-04
10 20 30
....*....|....*....|....*....|....*..
gi 555243212 348 YFNCIRDCDTHLDRILNELDALKLTDKTIVVFTADHG 384
Cdd:COG1524 207 YRAALREVDAALGRLLDALKARGLYEGTLVIVTADHG 243
|
|
| |
