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Conserved domains on  [gi|555244633|ref|WP_023228935|]
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sensor histidine kinase [Salmonella enterica]

Protein Classification

sensor histidine kinase( domain architecture ID 11461754)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
dpiB super family cl33069
sensor histidine kinase DpiB; Provisional
 10-539 2.82e-161

sensor histidine kinase DpiB; Provisional


The actual alignment was detected with superfamily member PRK15053:

Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 469.70  E-value: 2.82e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  10 FARRSFQNRIFLLILFTSTIVMLAITWYLTDITKERLHYQVGQRALIQAMQISAMPELVEAVEAHDLSRIKALIDPMRSF 89
Cdd:PRK15053  13 FQRLAFPLRIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  90 SDATYITVGNEKGQRLYHVNPDEIGKYMEGgDSDDALYNAKSYVSVRKGSLGSSLRGKSPIQDSTGKVIGIVSVGYTLEQ 169
Cdd:PRK15053  93 TDFDYVVIGDRHSIRLYHPNPEKIGYPMQF-TKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 170 LESWLNLQISSLLFPMALLLLVLLYCARRFSLHIKKQMLNMEPQQLSQLLIQQSVLFESVFEGLIAIDSHHRITAINQTA 249
Cdd:PRK15053 172 IDSWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 250 RRLLNLSQPESELIGYAIHHIVLPEAFFYDAPQKNKKDEIVTFNQMKVIASRMAVIIDNQPQGWVISFRNKDDINTLSLQ 329
Cdd:PRK15053 252 RKMLGLSSPGRQWLGKPIAEVVRPADFFTEQIDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQ 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 330 LSQVRQYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDFISHNFRDHHLAGLLIGKYYRAKELGL 409
Cdd:PRK15053 332 LTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 410 ELIFDPSSFVEHLPSSLSHNEWISIVGNLLDNAYNATLLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFER 489
Cdd:PRK15053 412 KMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 555244633 490 GVTTHNN--GDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:PRK15053 492 GVSTRADepGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPN 543
 
Name Accession Description Interval E-value
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 10-539 2.82e-161

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 469.70  E-value: 2.82e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  10 FARRSFQNRIFLLILFTSTIVMLAITWYLTDITKERLHYQVGQRALIQAMQISAMPELVEAVEAHDLSRIKALIDPMRSF 89
Cdd:PRK15053  13 FQRLAFPLRIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  90 SDATYITVGNEKGQRLYHVNPDEIGKYMEGgDSDDALYNAKSYVSVRKGSLGSSLRGKSPIQDSTGKVIGIVSVGYTLEQ 169
Cdd:PRK15053  93 TDFDYVVIGDRHSIRLYHPNPEKIGYPMQF-TKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 170 LESWLNLQISSLLFPMALLLLVLLYCARRFSLHIKKQMLNMEPQQLSQLLIQQSVLFESVFEGLIAIDSHHRITAINQTA 249
Cdd:PRK15053 172 IDSWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 250 RRLLNLSQPESELIGYAIHHIVLPEAFFYDAPQKNKKDEIVTFNQMKVIASRMAVIIDNQPQGWVISFRNKDDINTLSLQ 329
Cdd:PRK15053 252 RKMLGLSSPGRQWLGKPIAEVVRPADFFTEQIDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQ 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 330 LSQVRQYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDFISHNFRDHHLAGLLIGKYYRAKELGL 409
Cdd:PRK15053 332 LTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 410 ELIFDPSSFVEHLPSSLSHNEWISIVGNLLDNAYNATLLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFER 489
Cdd:PRK15053 412 KMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 555244633 490 GVTTHNN--GDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:PRK15053 492 GVSTRADepGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPN 543
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 224-538 3.85e-96

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 297.53  E-value: 3.85e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 224 VLFESVFEGLIAIDSHHRITAINQTARRLLNLsqpesELIGYAIHHIvlpeafFYDAPQKNKKDEIVTFNQMKVIASRMA 303
Cdd:COG3290   88 AVLESIREGVIAVDRDGRITLINDAARRLLGL-----DAIGRPIDEV------LAEVLETGERDEEILLNGRVLVVNRVP 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 304 VIIDNQPQGWVISFRNKDDINTLSLQLSQVRQYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDF 383
Cdd:COG3290  157 IRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 384 ISHNFRDHHLAGLLIGKYYRAKELGLELIFDPSSFVEHLPssLSHNEWISIVGNLLDNAYNATLLNREGSRQIECLINSE 463
Cdd:COG3290  237 LLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLP--LSDTDLVTILGNLLDNAIEAVEKLPEEERRVELSIRDD 314

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 555244633 464 GNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTRE 538
Cdd:COG3290  315 GDELVIEVEDSGPGIPEELLEKIFERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-534 1.47e-40

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 142.04  E-value: 1.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 431 WISIVGNLLDNAYNATLLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDHGIGLWLVHSYV 510
Cdd:cd16915    1 LITIVGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 555244633 511 KQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 434-536 3.82e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 91.56  E-value: 3.82e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633   434 IVGNLLDNAYNATllnrEGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD----HGIGLWLVHSY 509
Cdd:smart00387   9 VLSNLLDNAIKYT----PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*..
gi 555244633   510 VKQANGDIIVDNNSPFGTIFTLYIPFT 536
Cdd:smart00387  85 VELHGGEISVESEPGGGTTFTITLPLE 111
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 42-172 8.69e-20

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 85.54  E-value: 8.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633   42 TKERLHYQVGQRALIQAMQISAMPELVEAV-EAHDLSRIKALIDPMRSFSDATYITVGNEKGQRLYHVNPDEIGKYMEGG 120
Cdd:pfam17203   2 LRADLTRQLERRALALARSVAASPVVRVALtDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSGP 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 555244633  121 DSDDALYNAKSYVSVRKGSLGSSLRGKSPIQDSTGKVIGIVSVGYTLEQLES 172
Cdd:pfam17203  82 ATAPALTAGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQDSITA 133
 
Name Accession Description Interval E-value
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 10-539 2.82e-161

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 469.70  E-value: 2.82e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  10 FARRSFQNRIFLLILFTSTIVMLAITWYLTDITKERLHYQVGQRALIQAMQISAMPELVEAVEAHDLSRIKALIDPMRSF 89
Cdd:PRK15053  13 FQRLAFPLRIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  90 SDATYITVGNEKGQRLYHVNPDEIGKYMEGgDSDDALYNAKSYVSVRKGSLGSSLRGKSPIQDSTGKVIGIVSVGYTLEQ 169
Cdd:PRK15053  93 TDFDYVVIGDRHSIRLYHPNPEKIGYPMQF-TKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 170 LESWLNLQISSLLFPMALLLLVLLYCARRFSLHIKKQMLNMEPQQLSQLLIQQSVLFESVFEGLIAIDSHHRITAINQTA 249
Cdd:PRK15053 172 IDSWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 250 RRLLNLSQPESELIGYAIHHIVLPEAFFYDAPQKNKKDEIVTFNQMKVIASRMAVIIDNQPQGWVISFRNKDDINTLSLQ 329
Cdd:PRK15053 252 RKMLGLSSPGRQWLGKPIAEVVRPADFFTEQIDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQ 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 330 LSQVRQYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDFISHNFRDHHLAGLLIGKYYRAKELGL 409
Cdd:PRK15053 332 LTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 410 ELIFDPSSFVEHLPSSLSHNEWISIVGNLLDNAYNATLLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFER 489
Cdd:PRK15053 412 KMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 555244633 490 GVTTHNN--GDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:PRK15053 492 GVSTRADepGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPN 543
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 224-538 3.85e-96

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 297.53  E-value: 3.85e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 224 VLFESVFEGLIAIDSHHRITAINQTARRLLNLsqpesELIGYAIHHIvlpeafFYDAPQKNKKDEIVTFNQMKVIASRMA 303
Cdd:COG3290   88 AVLESIREGVIAVDRDGRITLINDAARRLLGL-----DAIGRPIDEV------LAEVLETGERDEEILLNGRVLVVNRVP 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 304 VIIDNQPQGWVISFRNKDDINTLSLQLSQVRQYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDF 383
Cdd:COG3290  157 IRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 384 ISHNFRDHHLAGLLIGKYYRAKELGLELIFDPSSFVEHLPssLSHNEWISIVGNLLDNAYNATLLNREGSRQIECLINSE 463
Cdd:COG3290  237 LLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLP--LSDTDLVTILGNLLDNAIEAVEKLPEEERRVELSIRDD 314

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 555244633 464 GNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTRE 538
Cdd:COG3290  315 GDELVIEVEDSGPGIPEELLEKIFERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 21-539 5.89e-79

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 257.53  E-value: 5.89e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  21 LLILFTSTIVMLAITwyLTDI-----TKERLHYQVGQRALIQAMQISAMPELVEA-VEAHDLSRIKALIDPMRSFSDATY 94
Cdd:PRK11086  19 TVTLMVSAVVFSVLL--VVHLlyfsqISRMTRDGLAEKALAIARTVADSPIVIQGlQGKPDESGIQTYAEAVRKRNDLLF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  95 ITVGNEKGQRLYHVNPDEIGKYMEGGDSDDALyNAKSYVSVRKGSLGSSLRGKSPIQDSTGKVIGIVSVGYTLEQLESWL 174
Cdd:PRK11086  97 IVVTDMQGIRYSHPNPQKIGKHFIGGDELPAL-KGKENVSINRGTLGQALRVFTPVYDENGKQIGVVAVGISLSEVTEQI 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 175 NLQISSLLFPMALLLLVLLYCARRFSLHIKKQMLNMEPQQLSQLLIQQSVLFESVFEGLIAIDSHHRITAINQTARRLLN 254
Cdd:PRK11086 176 NESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRGEVTLINDEAKRLFN 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 255 LSQP-ESELIGYAIHHIvLPEAFFYDAPQKNK--KDEIVTFNQMKVIASRMAVIIDNQPQGWVISFRNKDDINTLSLQLS 331
Cdd:PRK11086 256 YKKGlEDDPLGTDVESW-MPVSRLKEVLRTGTprRDEEININGRLLLTNTVPVRVNGEIIGAIATFRDKTEVRQLAQRLD 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 332 QVRQYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDFISHNFRDHHLAGLLIGKYYRAKELGLEL 411
Cdd:PRK11086 335 GMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISRARELGITL 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 412 IFDPSSFVEHLPSSLSHNEWISIVGNLLDNAYNAtlLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGV 491
Cdd:PRK11086 415 IISEDSQLPDSGDEDQVHELITILGNLIENALEA--VGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY 492

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 555244633 492 TTHNNGdHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:PRK11086 493 STKGSN-RGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGER 539
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-534 1.47e-40

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 142.04  E-value: 1.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 431 WISIVGNLLDNAYNATLLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDHGIGLWLVHSYV 510
Cdd:cd16915    1 LITIVGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 555244633 511 KQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
225-539 1.01e-27

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 114.17  E-value: 1.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 225 LFESVFEGLIAIDSHHRITAINQTARRLLNLSqpESELIGYAIHHIVLPEAFFYDA---------PQKNKKDEIVTFNQM 295
Cdd:COG3852   12 ILDSLPDAVIVLDADGRITYVNPAAERLLGLS--AEELLGRPLAELFPEDSPLRELleralaegqPVTEREVTLRRKDGE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 296 KVIAS-RMAVIID-NQPQGWVISFRnkdDInTLSLQLSQVRQYADNLRAVQ-------HEHRNLISTIAGLL-FLKR--- 362
Cdd:COG3852   90 ERPVDvSVSPLRDaEGEGGVLLVLR---DI-TERKRLERELRRAEKLAAVGelaaglaHEIRNPLTGIRGAAqLLERelp 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 363 ---YDNALALIQQQSE------------SHQKVLDFISHNFRD--HHLAGLLIGKYYRAKELglELIFDPSsfvehLPS- 424
Cdd:COG3852  166 ddeLREYTQLIIEEADrlnnlvdrllsfSRPRPPEREPVNLHEvlERVLELLRAEAPKNIRI--VRDYDPS-----LPEv 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 425 SLSHNEWISIVGNLLDNAYNAtlLNREG--------SRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNN 496
Cdd:COG3852  239 LGDPDQLIQVLLNLVRNAAEA--MPEGGtitirtrvERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 555244633 497 GdHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:COG3852  317 G-TGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAE 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 225-539 7.64e-27

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 112.75  E-value: 7.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 225 LFESVFE----GLIAIDSHHRITAINQTARRLLNLsqPESELIGYAIHHIVLP---EAFFYDAPQKNKKDEI-VTFNQMK 296
Cdd:COG5000   91 YLETILEnlpaGVIVLDADGRITLANPAAERLLGI--PLEELIGKPLEELLPEldlAELLREALERGWQEEIeLTRDGRR 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 297 VIASRMAVIIDNqpqGWVISFrnkDDINTLsLQLSQVRQYADNLRAVQHEHRNLISTIAGLL-FLKRY------------ 363
Cdd:COG5000  169 TLLVRASPLRDD---GYVIVF---DDITEL-LRAERLAAWGELARRIAHEIKNPLTPIQLSAeRLRRKladkleedredl 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 364 DNALALIQQQSESHQKVLDFISH-------NFRDHHLAGL------LIGKYYRAKELGLELIFDPssfvEHLPSSLSHNE 430
Cdd:COG5000  242 ERALDTIIRQVDRLKRIVDEFLDfarlpepQLEPVDLNELlrevlaLYEPALKEKDIRLELDLDP----DLPEVLADRDQ 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 431 WISIVGNLLDNAYNATllnrEGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGdHGIGLWLVHSYV 510
Cdd:COG5000  318 LEQVLINLLKNAIEAI----EEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKG-TGLGLAIVKKIV 392

                        330       340
                 ....*....|....*....|....*....
gi 555244633 511 KQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:COG5000  393 EEHGGTIELESRPGGGTTFTIRLPLAEEA 421
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 434-536 3.82e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 91.56  E-value: 3.82e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633   434 IVGNLLDNAYNATllnrEGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD----HGIGLWLVHSY 509
Cdd:smart00387   9 VLSNLLDNAIKYT----PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*..
gi 555244633   510 VKQANGDIIVDNNSPFGTIFTLYIPFT 536
Cdd:smart00387  85 VELHGGEISVESEPGGGTTFTITLPLE 111
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
335-536 2.39e-21

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 94.97  E-value: 2.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 335 QYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDFISHNFRDhhlaglligkyyRAKELGLELIFD 414
Cdd:COG0642  142 EQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRP------------LAEEKGIELELD 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 415 PSsfvEHLPSSLSHNEWIS-IVGNLLDNAYNATllnREGSRqIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTT 493
Cdd:COG0642  210 LP---DDLPTVRGDPDRLRqVLLNLLSNAIKYT---PEGGT-VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRT 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 555244633 494 HNNGDH---GIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFT 536
Cdd:COG0642  283 DPSRRGggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
329-534 2.13e-20

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 90.35  E-value: 2.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 329 QLSQVRQYADN-LRAVQHEHRNLISTIAGLL-FLKRYDN--------ALALIQQQS----------------ESHQKVLD 382
Cdd:COG2205    8 ELEELERLKSEfLANVSHELRTPLTSILGAAeLLLDEEDlspeerreLLEIIRESAerllrliedlldlsrlESGKLSLE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 383 FISHNFRDhhLAGLLIGKYY-RAKELGLELIFDPSsfvEHLPSSLSHNEWIS-IVGNLLDNAYNATllnREGSRqIECLI 460
Cdd:COG2205   88 LEPVDLAE--LLEEAVEELRpLAEEKGIRLELDLP---PELPLVYADPELLEqVLANLLDNAIKYS---PPGGT-ITISA 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 555244633 461 NSEGNEVIIEVADQGCGIDENIRQHIFE---RGVTTHNNGDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:COG2205  159 RREGDGVRISVSDNGPGIPEEELERIFErfyRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
224-539 3.12e-20

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 94.26  E-value: 3.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 224 VLFESVFEGLIAIDSHHRITAINQTARRLLNLsqPESELIGYAIHHIVLPEAFFY----DAPQKNK--KDEIVTFN---- 293
Cdd:PRK11360 266 LILESIADGVIAIDRQGKITTMNPAAEVITGL--QRHELVGKPYSELFPPNTPFAspllDTLEHGTehVDLEISFPgrdr 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 294 --QMKVIASRMAViIDNQPQGWVISFRnkdDINTLSLQLSQVRQyADNLRA-------VQHEHRNLISTIAGLL-FLKRY 363
Cdd:PRK11360 344 tiELSVSTSLLHN-THGEMIGALVIFS---DLTERKRLQRRVAR-QERLAAlgelvagVAHEIRNPLTAIRGYVqIWRQQ 418

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 364 DN------ALALIQQQSES----HQKVLDF----------ISHNFRDHHLAGLLIGKYYRAKeLGLELIFDPSsfvehLP 423
Cdd:PRK11360 419 TSdppsqeYLSVVLREVDRlnkvIDQLLEFsrpresqwqpVSLNALVEEVLQLFQTAGVQAR-VDFETELDNE-----LP 492

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 424 SSLSHNEWISIV-GNLLDNAYNAtlLNREGSRQIECLINSEGNeVIIEVADQGCGIDENIRQHIFERGVTTHNNGDhGIG 502
Cdd:PRK11360 493 PIWADPELLKQVlLNILINAVQA--ISARGKIRIRTWQYSDGQ-VAVSIEDNGCGIDPELLKKIFDPFFTTKAKGT-GLG 568

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 555244633 503 LWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTREE 539
Cdd:PRK11360 569 LALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQG 605
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 42-172 8.69e-20

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 85.54  E-value: 8.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633   42 TKERLHYQVGQRALIQAMQISAMPELVEAV-EAHDLSRIKALIDPMRSFSDATYITVGNEKGQRLYHVNPDEIGKYMEGG 120
Cdd:pfam17203   2 LRADLTRQLERRALALARSVAASPVVRVALtDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSGP 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 555244633  121 DSDDALYNAKSYVSVRKGSLGSSLRGKSPIQDSTGKVIGIVSVGYTLEQLES 172
Cdd:pfam17203  82 ATAPALTAGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQDSITA 133
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 434-537 7.28e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 79.33  E-value: 7.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  434 IVGNLLDNAYNATLlnreGSRQIECLInSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNN--GDHGIGLWLVHSYVK 511
Cdd:pfam02518   9 VLSNLLDNALKHAA----KAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRggGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....*.
gi 555244633  512 QANGDIIVDNNSPFGTIFTLYIPFTR 537
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLPLAQ 109
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 434-534 8.10e-17

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 82.15  E-value: 8.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNAtlLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD-HGIGLWLVHSYVKQ 512
Cdd:COG4191  260 VLLNLLINAIDA--MEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKgTGLGLSISYGIVEK 337

                         90       100
                 ....*....|....*....|..
gi 555244633 513 ANGDIIVDNNSPFGTIFTLYIP 534
Cdd:COG4191  338 HGGRIEVESEPGGGTTFTITLP 359
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
335-538 8.42e-14

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 73.05  E-value: 8.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 335 QYADNLRAVQHEHRNLISTIAGLLFLKRYDNALALIQQQSESHQKVLDFISHNFRDhhlaglligkyyRAKELGLELIFD 414
Cdd:COG5002  200 ERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRP------------LAEEKGIELELD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 415 PSSfvEHLPSSLSHNEWISIVGNLLDNAYNATllnREGSRqIECLINSEGNEVIIEVADQGCGIDENIRQHIFER----- 489
Cdd:COG5002  268 LPE--DPLLVLGDPDRLEQVLTNLLDNAIKYT---PEGGT-ITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERfyrvd 341

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 555244633 490 GVTTHNNGDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTRE 538
Cdd:COG5002  342 KSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-534 7.47e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 64.75  E-value: 7.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 437 NLLDNAYNAtlLNREGSRQIECLINSEgnEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD-HGIGLWLVHSYVKQANG 515
Cdd:cd16943   10 NLLVNAAQA--MEGRGRITIRTWAHVD--QVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEgTGLGLSLSYRIIQKHGG 85

                         90
                 ....*....|....*....
gi 555244633 516 DIIVDNNSPFGTIFTLYIP 534
Cdd:cd16943   86 TIRVASVPGGGTRFTIILP 104
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 434-534 8.11e-12

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 62.12  E-value: 8.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNATllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFER-----GVTTHNNGDHGIGLWLVHS 508
Cdd:cd16925    8 VVLNLLSNAFKFT---PDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERfrqgdGSSTRAHGGTGLGLSIVKE 84

                         90       100
                 ....*....|....*....|....*.
gi 555244633 509 YVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16925   85 FVELHGGTVTVSDAPGGGALFQVELP 110
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 225-335 8.76e-11

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 64.02  E-value: 8.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 225 LFESVFEGLIAIDSHHRITAINQTARRLLNLsqPESELIGYAIhHIVLPEAFFYDAPQKNKKDEIVTFN----QMKVIAS 300
Cdd:COG3829   16 ILDSLDDGIIVVDADGRITYVNRAAERILGL--PREEVIGKNV-TELIPNSPLLEVLKTGKPVTGVIQKtggkGKTVIVT 92

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 555244633 301 RMAVIIDNQPQGWVISFRNKDDINTLSLQLSQVRQ 335
Cdd:COG3829   93 AIPIFEDGEVIGAVETFRDITELKRLERKLREEEL 127
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 225-534 9.30e-11

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 63.98  E-value: 9.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 225 LFESVFEGLIAIDSHHRITAINQTARRLLNLsqPESELIGYAIHHIVLPE--AFFYDAPQKNKK--------DEIVTFNQ 294
Cdd:COG5805  162 LIENSPDLICVIDTDGRILFINESIERLFGA--PREELIGKNLLELLHPCdkEEFKERIESITEvwqefiieREIITKDG 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 295 mKVIASRMAVI----IDNQPQGWVISFRnkdDINTL---------SLQLSQVRQYAdnlRAVQHEHRNLISTIAGLLFL- 360
Cdd:COG5805  240 -RIRYFEAVIVplidTDGSVKGILVILR---DITEKkeaeelmarSEKLSIAGQLA---AGIAHEIRNPLTSIKGFLQLl 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 361 -------KRY--------DNALALIQQ-----QSESHQKVLDFISHNFRDhhLAGLLigkYYRAKELGLELIFDPSSfvE 420
Cdd:COG5805  313 qpgiedkEEYfdimlselDRIESIISEflalaKPQAVNKEKENINELIQD--VVTLL---ETEAILHNIQIRLELLD--E 385

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 421 HLPSSLSHNEWISIVGNLLDNAYNAtlLNREGSRQIEclINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDhG 500
Cdd:COG5805  386 DPFIYCDENQIKQVFINLIKNAIEA--MPNGGTITIH--TEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGT-G 460

                        330       340       350
                 ....*....|....*....|....*....|....
gi 555244633 501 IGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:COG5805  461 LGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 393-533 2.65e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 58.36  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 393 LAGLLIGKYYRAKELGLELIFdpssfveHLPSSLSHN----EWISIVGNLLDNAYNATLLNREGSRQIECLINSEGNEVI 468
Cdd:cd16935    2 LDSLLSEKLELAREKGIEFTI-------EIDIPILLPisplDLCIIFGNLLDNAIEACAKIDKENRFIHLKIRQKKGFLI 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 555244633 469 IEVadqgcgidENIRQH----IFERGVTTHNNGDHGIGLWLVHSYVKQANGDIIVDNNSPfgtIFTLYI 533
Cdd:cd16935   75 ISI--------ENSYEGelkkKNGLFLSTKKDKNHGIGLKSIREIVKKYNGNLSIEYENG---IFTLSI 132
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 399-526 4.70e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 57.64  E-value: 4.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 399 GKYYRAKELGLELIFDPS-SFVEHlpsslsHNEWISIVGNLLDNAYnatllnREGSRQIE-CLINSEGNEVIIeVADQGC 476
Cdd:cd16954   11 NKVYQRKGVSISLDISPElRFPGE------RNDLMELLGNLLDNAC------KWCLEFVEvTARQTDGGLHLI-VDDDGP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 555244633 477 GIDENIRQHIFERG--VTTHNNGdHGIGLWLVHSYVKQANGDIIVdNNSPFG 526
Cdd:cd16954   78 GVPESQRSKIFQRGqrLDEQRPG-QGLGLAIAKEIVEQYGGELSL-SDSPLG 127
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 463-534 4.40e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 54.31  E-value: 4.40e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 555244633 463 EGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD-HGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16919   44 PGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKgTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 434-535 7.86e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 53.27  E-value: 7.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNATllnREGSRQIEC---LINSEGNEVIIEVADQGCGIDENIRQHIFER-----GVTTHNNGDHGIGLWL 505
Cdd:cd16922    4 ILLNLLGNAIKFT---EEGEVTLRVsleEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPfsqadSSTTRKYGGTGLGLAI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 555244633 506 VHSYVKQANGDIIVDNNSPFGTIFTLYIPF 535
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
339-534 8.59e-09

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 57.87  E-value: 8.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 339 NLRA-VQHEHRNLISTIAGL--LFLKRY-----DNALA----------------LIQQQSESH-----QKVLDFISHNFR 389
Cdd:PRK10364 239 HLAAgVAHEIRNPLSSIKGLakYFAERApaggeAHQLAqvmakeadrlnrvvseLLELVKPTHlalqaVDLNDLINHSLQ 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 390 dhhlaglLIGKYYRAKELGLEliFDPSSFVEHLPssLSHNEWISIVGNLLDNAYNAtlLNREGSrqIECLINSEGNEVII 469
Cdd:PRK10364 319 -------LVSQDANSREIQLR--FTANDTLPEIQ--ADPDRLTQVLLNLYLNAIQA--IGQHGV--ISVTASESGAGVKI 383

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 555244633 470 EVADQGCGIDENIRQHIFERGVTTHNNGDhGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK10364 384 SVTDSGKGIAADQLEAIFTPYFTTKAEGT-GLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 225-534 1.70e-08

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 56.91  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 225 LFESVFEGLIAIDSHHRITAINQTARRLLNLSqpESELIGYAIHHIVLPE------AFFYDAPQ-KNKKDEIVTF----N 293
Cdd:COG5809  146 IFNHSPDGIIVTDLDGRIIYANPAACKLLGIS--IEELIGKSILELIHSDdqenvaAFISQLLKdGGIAQGEVRFwtkdG 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 294 QMKVIASRMAVIIDN-QPQGWVISFRnkdDInTLSLQLSQVRQYADNLRAV-------QHEHRNLISTIAGLLFLKRYDn 365
Cdd:COG5809  224 RWRLLEASGAPIKKNgEVDGIVIIFR---DI-TERKKLEELLRKSEKLSVVgelaagiAHEIRNPLTSLKGFIQLLKDT- 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 366 alALIQQQS-----ESHQKVLDFISHNFrdhhlagLLIGKyyrAKELGLELiFDPSSFVEHL-----PSSLSHNEWIS-- 433
Cdd:COG5809  299 --IDEEQKTyldimLSELDRIESIISEF-------LVLAK---PQAIKYEP-KDLNTLIEEVipllqPQALLKNVQIEle 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 -------IVG----------NLLDNAYNATllNREGSRQIEcLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNN 496
Cdd:COG5809  366 leddipdILGdenqlkqvfiNLLKNAIEAM--PEGGNITIE-TKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEK 442

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 555244633 497 gdhGIGLWLVHSY--VKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:COG5809  443 ---GTGLGLMVSYkiIEEHGGKITVESEVGKGTTFSITLP 479
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
464-534 8.63e-08

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 55.07  E-value: 8.63e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555244633 464 GNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDhGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK13837 605 GRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGT-GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 433-533 1.17e-07

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 49.91  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  433 SIVGNLLDNAYNATLLNREGsRQIECLINSEGNEVIIEVaDQGCGIDENIRQHIFErgvTTHNNGDHGIGLWLVHSYVKQ 512
Cdd:pfam14501   8 VIFGNLLDNAIEACSKIDDN-RFIRLKIREKQNFLIIRI-ENTYEGELKFEGKLPS---TKTKGDGHGIGLKSIRRIVKK 82

                          90       100
                  ....*....|....*....|.
gi 555244633  513 ANGDIIVDNNSPfgtIFTLYI 533
Cdd:pfam14501  83 YGGNLSTEIENG---IFTLSI 100
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-534 1.37e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 49.98  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 431 WIS-IVGNLLDNAYNATLLNREGSRQIECLinseGNEVIIEVADQGCGIDENIRQHIFERGVTThNNGDH-----GIGLW 504
Cdd:cd16948    5 WLSfIIGQIVSNALKYSKQGGKIEIYSETN----EQGVVLSIKDFGIGIPEEDLPRVFDKGFTG-ENGRNfqestGMGLY 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 555244633 505 LVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16948   80 LVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
434-538 3.63e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 52.71  E-value: 3.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNATLLNREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNgdHGIGLWLVHSYVKQA 513
Cdd:COG2972  340 ILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEG--RGIGLRNVRERLKLY 417

                         90       100
                 ....*....|....*....|....*...
gi 555244633 514 NGD---IIVDNNSPFGTIFTLYIPFTRE 538
Cdd:COG2972  418 YGEeygLEIESEPGEGTTVTIRIPLEEE 445
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-534 3.86e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.58  E-value: 3.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 437 NLLDNAYnatllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGV-----TTHNNGDHGIGLWLVHSYVK 511
Cdd:cd16939    7 NLLRNAL------RYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsRDRATGGFGLGLAIVHRVAL 80

                         90       100
                 ....*....|....*....|...
gi 555244633 512 QANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16939   81 WHGGHVECDDSELGGACFRLTWP 103
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
391-526 5.19e-07

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 52.33  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 391 HHLAGLL------IGKYYRAKelGLELIFDPS---SFVEHlpsslsHNEWISIVGNLLDNAYNATLLNREGSRQIeclin 461
Cdd:PRK10815 338 HSVAPLLdnltsaLNKVYQRK--GVNITLDISpeiTFVGE------KNDFMEVMGNVLDNACKYCLEFVEISARQ----- 404

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 555244633 462 sEGNEVIIEVADQGCGIDENIRQHIFERG--VTTHNNGdHGIGLWLVHSYVKQANGDIIVdNNSPFG 526
Cdd:PRK10815 405 -TDEHLHIVVEDDGPGIPESKRELIFDRGqrADTLRPG-QGLGLSVAREITEQYEGKISA-GDSPLG 468
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-534 5.55e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 48.09  E-value: 5.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 437 NLLDNAYnatllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFE-----RGVTTHNNGDHGIGLWLVHSYVK 511
Cdd:cd16949    7 NVLRNAL------RYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLpfyrvDSARDRESGGTGLGLAIAERAIE 80

                         90       100
                 ....*....|....*....|...
gi 555244633 512 QANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16949   81 QHGGKIKASNRKPGGLRVRIWLP 103
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 6.87e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 47.83  E-value: 6.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYnatllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFE---RGVTTHNNGDHGIGLWLVHSYV 510
Cdd:cd16950    4 VLSNLVDNAL------RYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQpfyRGDNARGTSGTGLGLAIVQRIS 77

                         90       100
                 ....*....|....*....|....
gi 555244633 511 KQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16950   78 DAHGGSLTLANRAGGGLCARIELP 101
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-534 2.37e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 46.24  E-value: 2.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 437 NLLDNAYNAtlLNREGSRQIECLINSEGNE---VIIEVADQGCGIDENIRQHIFERGVTTHNNGdHGIGLWLVHSYVKQA 513
Cdd:cd16920    7 NLVRNGIEA--MSEGGCERRELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFYTTKSEG-LGMGLSICRSIIEAH 83

                         90       100
                 ....*....|....*....|.
gi 555244633 514 NGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16920   84 GGRLSVESPAGGGATFQFTLP 104
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 469-534 2.49e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 46.24  E-value: 2.49e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555244633 469 IEVADQGCGIDENIRQHIFERGVTTHNNGDhGIGLWLVHSYVKQANGDIIVDnNSPFGTIFTLYIP 534
Cdd:cd16918   46 VSVIDNGPGIPPDLQDTIFYPMVSGRENGT-GLGLAIAQNIVSQHGGVIECD-SQPGHTVFSVSLP 109
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 435-522 2.88e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 46.25  E-value: 2.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 435 VGNLLDNAYNATllnREGSRqIECLINSEGNEVIIeVADQGCGIDENIRQHIFERGVTT--HNNGDHGIGLWLVHSYVKQ 512
Cdd:cd16940   18 LRNLVDNAVRYS---PQGSR-VEIKLSADDGAVIR-VEDNGPGIDEEELEALFERFYRSdgQNYGGSGLGLSIVKRIVEL 92

                         90
                 ....*....|
gi 555244633 513 ANGDIIVDNN 522
Cdd:cd16940   93 HGGQIFLGNA 102
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 432-531 4.16e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 45.53  E-value: 4.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 432 ISIVGNLLDNAYNATLLNREGSRQIECLInsEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGDH-GIGLWLVHSYV 510
Cdd:cd16976    2 QQVLMNLLQNALDAMGKVENPRIRIAARR--LGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGtGLGLSISYGIV 79

                         90       100
                 ....*....|....*....|.
gi 555244633 511 KQANGDIIVDNNSPFGTIFTL 531
Cdd:cd16976   80 EEHGGRLSVANEEGAGARFTF 100
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
416-534 4.31e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 49.73  E-value: 4.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633  416 SSFVEHLPSSLSHNEWISIVGNLLDNAYNATllnREGSRQIEC-LINSEGNEVIIE--VADQGCGIDENIRQHIFERGVT 492
Cdd:PRK09959  814 STFPDHYLVKIDPQAFKQVLSNLLSNALKFT---TEGAVKITTsLGHIDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQ 890

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 555244633  493 T---HNNGDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK09959  891 TsagRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
PRK15347 PRK15347
two component system sensor kinase;
434-536 6.29e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 49.26  E-value: 6.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNATllnreGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGV-TTHNNGDHGIGLWLVHSYVKQ 512
Cdd:PRK15347 517 ILVNLLGNAVKFT-----ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYqADTHSQGTGLGLTIASSLAKM 591

                         90       100
                 ....*....|....*....|....
gi 555244633 513 ANGDIIVDNNSPFGTIFTLYIPFT 536
Cdd:PRK15347 592 MGGELTLFSTPGVGSCFSLVLPLN 615
PRK10604 PRK10604
sensor protein RstB; Provisional
 434-534 7.05e-06

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 48.45  E-value: 7.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYnatllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFE--------RGVTThnnGDHGIGLWL 505
Cdd:PRK10604 323 VLDNLLNNAL------RYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEpfvrldpsRDRAT---GGCGLGLAI 393

                         90       100
                 ....*....|....*....|....*....
gi 555244633 506 VHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK10604 394 VHSIALAMGGSVNCDESELGGARFSFSWP 422
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 463-534 7.60e-06

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 46.42  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 463 EGNEVIIEVADQGCGID-ENIRQHIFERGVTTHNNGD---------------------------HGIGLWLVHSYVKQAN 514
Cdd:cd16916   79 QGNQVVIEVSDDGRGIDrEKIREKAIERGLITADEAAtlsddevlnlifapgfstaeqvtdvsgRGVGMDVVKRSIESLG 158

                         90       100
                 ....*....|....*....|
gi 555244633 515 GDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16916  159 GTIEVESEPGQGTTFTIRLP 178
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-526 1.02e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 44.76  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNATllNREGSRQIECliNSEGNEVIIEVADQGCGIDENIRQHIFER-----GVTTHNNGDHGIGLWLVHS 508
Cdd:cd16946    8 LFVNLLENSLRYT--DTGGKLRIRA--AQTPQEVRLDVEDSAPGVSDDQLARLFERfyrveSSRNRASGGSGLGLAICHN 83

                         90
                 ....*....|....*...
gi 555244633 509 YVKQANGDIIVDnNSPFG 526
Cdd:cd16946   84 IALAHGGTISAE-HSPLG 100
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 437-534 1.17e-05

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 47.86  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 437 NLLDNA--YNAtllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD---HGIGLWLVHSYVK 511
Cdd:COG4251  401 NLISNAikYSR----PGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEyegTGIGLAIVKKIVE 476

                         90       100
                 ....*....|....*....|...
gi 555244633 512 QANGDIIVDNNSPFGTIFTLYIP 534
Cdd:COG4251  477 RHGGRIWVESEPGEGATFYFTLP 499
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
463-536 1.26e-05

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 47.87  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 463 EGNEVIIEVADQGCGID-ENIRQHIFERGVTTHNNGDH---------------------------GIGLWLVHSYVKQAN 514
Cdd:COG0643  318 EGGRVVIEVSDDGRGLDlEKIRAKAIEKGLITAEEAAAlsdeellelifapgfstaeevtdlsgrGVGMDVVKTNIEALG 397

                         90       100
                 ....*....|....*....|..
gi 555244633 515 GDIIVDNNSPFGTIFTLYIPFT 536
Cdd:COG0643  398 GTIEIESEPGKGTTFTLRLPLT 419
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 435-534 4.21e-05

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 45.99  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 435 VGNLLDNAYNATllnREGSRqIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTT--HNNGDH--GIGLWLVHSYV 510
Cdd:PRK11100 373 LGNLLDNAIDFS---PEGGT-ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLprPANGRKstGLGLAFVREVA 448

                         90       100
                 ....*....|....*....|....
gi 555244633 511 KQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK11100 449 RLHGGEVTLRNRPEGGVLATLTLP 472
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 403-537 4.55e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 46.44  E-value: 4.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 403 RAKELGLELIFDpssFVEHLPSSLSHN--EWISIVGNLLDNAYNATllnREGSRQIECliNSEGNEVIIEVADQGCGIDE 480
Cdd:PRK11466 535 RVKGRPIRLATD---IADDLPTALMGDprRIRQVITNLLSNALRFT---DEGSIVLRS--RTDGEQWLVEVEDSGCGIDP 606

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 555244633 481 NIRQHIFERGV-TTHNNGDHGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFTR 537
Cdd:PRK11466 607 AKLAEIFQPFVqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRV 664
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 393-534 5.29e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 46.09  E-value: 5.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 393 LAGLLigkyyrAKELGLELIFDPSsfvEHLPSslshneWIS--------IVGNLLDNAYNATllnREGSRQIEClINSEG 464
Cdd:PRK11091 368 LSGLQ------AEQKGLRFDLEPL---LPLPH------KVItdgtrlrqILWNLISNAVKFT---QQGGVTVRV-RYEEG 428

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555244633 465 NEVIIEVADQGCGIDENIRQHIFER--GVTTHNNGDH----GIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK11091 429 DMLTFEVEDSGIGIPEDELDKIFAMyyQVKDSHGGKPatgtGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-531 8.76e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 42.50  E-value: 8.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYnatllnREGS--RQIECLINSEGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD-----HGIGLWLV 506
Cdd:cd16947   24 ILKNLISNAI------KYGSdgKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqgNGLGLTIT 97

                         90       100
                 ....*....|....*....|....*
gi 555244633 507 HSYVKQANGDIIVDNNSPFGTIFTL 531
Cdd:cd16947   98 KRLAESMGGSIYVNSKPYEKTVFTV 122
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 2.98e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 40.39  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYNatlLNREG-SRQIECLINSEGNEVIIEVADQGCGIDEniRQH-----IFERGVTTHNNGDHGIGLWLVH 507
Cdd:cd16921    4 VLTNLLGNAIK---FRRPRrPPRIEVGAEDVGEEWTFYVRDNGIGIDP--EYAekvfgIFQRLHSREEYEGTGVGLAIVR 78

                         90       100
                 ....*....|....*....|....*..
gi 555244633 508 SYVKQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:cd16921   79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
envZ PRK09467
osmolarity sensor protein; Provisional
 434-534 3.86e-04

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 42.98  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 434 IVGNLLDNAYnatllnREGSRQIECLINSEGNEVIIEVADQGCGIDENIRQHIFE---RGVTTHNNGDHGIGLWLVHSYV 510
Cdd:PRK09467 335 ALANLVVNAA------RYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQpftRGDSARGSSGTGLGLAIVKRIV 408

                         90       100
                 ....*....|....*....|....
gi 555244633 511 KQANGDIIVDNNSPFGTIFTLYIP 534
Cdd:PRK09467 409 DQHNGKVELGNSEEGGLSARAWLP 432
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 225-274 6.02e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.15  E-value: 6.02e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 555244633   225 LFESVFEGLIAIDSHHRITAINQTARRLLNLSQpeSELIGYAIHHIVLPE 274
Cdd:smart00091   6 ILESLPDGIFVLDLDGRILYANPAAEELLGYSP--EELIGKSLLELIHPE 53
PRK11388 PRK11388
DNA-binding transcriptional regulator DhaR; Provisional
 148-273 8.04e-04

DNA-binding transcriptional regulator DhaR; Provisional


Pssm-ID: 183114 [Multi-domain]  Cd Length: 638  Bit Score: 42.36  E-value: 8.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 148 SPIQDSTGKVIGIVSVGYTLE-QLESWLNLQISsllfpmallllvllyCARRFSLHIKKQMLNMEpqqLSQLLIQQSVLF 226
Cdd:PRK11388 148 TPVFDSKGRLTGTIALACPVEqTSAADLPLTLS---------------IAREVGNLLLTDSLLAE---SNRHLNQLNALL 209

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 555244633 227 ESVFEGLIAIDSHHRITAINQTARRLLNLSqpESELIGYAIH-HIVLP 273
Cdd:PRK11388 210 ESMDDGVIAWDEQGNLQFLNAQAARLLRLD--ATASQGRAITeLLTLP 255
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 435-521 1.30e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 38.60  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 435 VGNLLDNAYNATllnREGSrQIECLINSEGNEVIIEVADQGCGIDENIRQHIFER--GVTTHNNGDH--GIGLWLVHSYV 510
Cdd:cd16945    9 INNLLDNAIDFS---PEGG-LIALQLEADTEGIELLVFDEGSGIPDYALNRVFERfySLPRPHSGQKstGLGLAFVQEVA 84

                         90
                 ....*....|.
gi 555244633 511 KQANGDIIVDN 521
Cdd:cd16945   85 QLHGGRITLRN 95
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 438-539 1.54e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 41.04  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633 438 LLDNAY-NATLLNREGsrQIECLINSEGNEVIIEVADQGCGIDENIRQhifergvtthnNGDHGIGLWLVHSYVKQANGD 516
Cdd:COG3920  407 LVTNALkHAFLSGEGG--RIRVSWRREDGRLRLTVSDNGVGLPEDVDP-----------PARKGLGLRLIRALVRQLGGT 473

                         90       100
                 ....*....|....*....|...
gi 555244633 517 IIVDNNSpfGTIFTLYIPFTREE 539
Cdd:COG3920  474 LELDRPE--GTRVRITFPLAELA 494
PRK13557 PRK13557
histidine kinase; Provisional
 463-536 3.80e-03

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 40.04  E-value: 3.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 555244633 463 EGNEVIIEVADQGCGIDENIRQHIFERGVTTHNNGD-HGIGLWLVHSYVKQANGDIIVDNNSPFGTIFTLYIPFT 536
Cdd:PRK13557 321 PGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKgTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAS 395
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-534 3.93e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 37.04  E-value: 3.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555244633 462 SEGNEVIIEVADQGCGIDENirqhIFERGVTTHNNGDhGIGLWLVHSYVKQANGD---IIVDNNSPFGTIFTLYIP 534
Cdd:cd16924   33 KEDNHVMIEVEDNGRGIDPK----VLNILGKKPKEGN-GIGLYNVHQRLILLFGEdygIHIASEPDKGTRITFTIP 103
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 57-175 5.16e-03

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 38.86  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555244633   57 QAMQISAMPELVEAVEAHDLSRIKALIDPMRSFSDATYITVGNEKGQRLYHVNPDEIGKYMEGGDSD---DALYNAKSYV 133
Cdd:pfam02743  32 ILELLASNPDLQDLLSAPAEEELAKLESLLRSNPGISSIYLVDADGRVLASSDESPSYPGLDVSERPwykEALKGGGGII 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 555244633  134 SVRKGSLGSSLRGKS------PIQDSTGKVIGIVSVGYTLEQLESWLN 175
Cdd:pfam02743 112 WVFSSPYPSSESGEPvltiarPIYDDDGEVIGVLVADLDLDTLQELLS 159
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
434-510 6.15e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 37.20  E-value: 6.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 555244633 434 IVGNLLDNAYNatllnREGSRQIECLINSEGNEVIIEVADQGCGID-ENIRQHIFERgvtthnnGDHGIGLWLVHSYV 510
Cdd:COG2172   42 AVTNAVRHAYG-----GDPDGPVEVELELDPDGLEIEVRDEGPGFDpEDLPDPYSTL-------AEGGRGLFLIRRLM 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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