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Conserved domains on  [gi|560182447|ref|WP_023599045|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase [Lactobacillus johnsonii]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 56-233 2.38e-10

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member cd07989:

Pssm-ID: 473073 [Multi-domain]  Cd Length: 184  Bit Score: 58.05  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447  56 LFTYGIMHVKVIGRDKLFKykNEGYFIYGNHTQMVnDVFMPLTLFGWKNYYaIANQANWGIPVIGKTLLPYGGLPVG-KN 134
Cdd:cd07989    4 LLRLLGVRVRVEGLENLPP--KGPVIIVANHQSYL-DPLVLGAALPRPIRF-VAKKELFKIPFLGWLLRLLGAIPIDrGN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447 135 IKQAIKLLKAVKTLTKENAHIVIYPEAHVWPyYTSIRSFPETSFNFPVQANKA--SFVMTTTYQ----KRKFGKHPKITV 208
Cdd:cd07989   80 GRSAREALREAIEALKEGESVVIFPEGTRSR-DGELLPFKSGAFRLAKEAGVPivPVAISGTWGslpkGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*
gi 560182447 209 YIDGPFFPDSTLTKKEQQKKLHDQV 233
Cdd:cd07989  159 RIGEPIPPEGLELAEEDRKELREKV 183
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 56-233 2.38e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 58.05  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447  56 LFTYGIMHVKVIGRDKLFKykNEGYFIYGNHTQMVnDVFMPLTLFGWKNYYaIANQANWGIPVIGKTLLPYGGLPVG-KN 134
Cdd:cd07989    4 LLRLLGVRVRVEGLENLPP--KGPVIIVANHQSYL-DPLVLGAALPRPIRF-VAKKELFKIPFLGWLLRLLGAIPIDrGN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447 135 IKQAIKLLKAVKTLTKENAHIVIYPEAHVWPyYTSIRSFPETSFNFPVQANKA--SFVMTTTYQ----KRKFGKHPKITV 208
Cdd:cd07989   80 GRSAREALREAIEALKEGESVVIFPEGTRSR-DGELLPFKSGAFRLAKEAGVPivPVAISGTWGslpkGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*
gi 560182447 209 YIDGPFFPDSTLTKKEQQKKLHDQV 233
Cdd:cd07989  159 RIGEPIPPEGLELAEEDRKELREKV 183
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-249 2.65e-09

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 55.79  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447  36 IIKHTPLNYLMRFLAAGFAYLFTYgimHVKVIGRDKLFKykNEGYFIYGNHTQMVNDVFMPLTLfgWKNYYAIANQANWG 115
Cdd:COG0204    6 LLLRRFRYRLVRLWARLLLRLLGV---RVRVEGLENLPA--DGPVLIVANHQSWLDILLLLAAL--PRPVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447 116 IPVIGKTLLPYGGLPV-GKNIKQAIKLLKAVKTLTKENAHIVIYPEA------HVWPYYTS-----IRSfpetsfNFPVQ 183
Cdd:COG0204   79 IPLLGWLLRALGAIPVdRSKRRAALRALRQAVEALKAGESLVIFPEGtrspdgRLLPFKTGaarlaLEA------GVPIV 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 560182447 184 ankasfVMTTTY-----QKRKFGKHPKITVYIDGPFFPDStlTKKEQQKKLHDQVFDQLKKRSKNSSYQYY 249
Cdd:COG0204  153 ------PVAIDGteralPKGFLPRPGKVTVRIGPPIDPSD--LEGEDRRELAERLRAAIEALLAELRAEAA 215
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 63-160 2.01e-03

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 37.26  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447   63 HVKVIGRDKLfkYKNEGYFIYGNHTQMVNDVFMPLTLFGWKNYYAIANQANWG-IPVIGKTLLPYGGLPVG-KNIKQAIK 140
Cdd:pfam01553   1 RIEVHGLENL--PRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFdIPLVGWLMRLLGCIFIDrKNRKDAAG 78

                          90       100
                  ....*....|....*....|
gi 560182447  141 LLKAVKTLTKENAHIVIYPE 160
Cdd:pfam01553  79 TLEYLVELLREGKLVVIFPE 98
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 56-233 2.38e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 58.05  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447  56 LFTYGIMHVKVIGRDKLFKykNEGYFIYGNHTQMVnDVFMPLTLFGWKNYYaIANQANWGIPVIGKTLLPYGGLPVG-KN 134
Cdd:cd07989    4 LLRLLGVRVRVEGLENLPP--KGPVIIVANHQSYL-DPLVLGAALPRPIRF-VAKKELFKIPFLGWLLRLLGAIPIDrGN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447 135 IKQAIKLLKAVKTLTKENAHIVIYPEAHVWPyYTSIRSFPETSFNFPVQANKA--SFVMTTTYQ----KRKFGKHPKITV 208
Cdd:cd07989   80 GRSAREALREAIEALKEGESVVIFPEGTRSR-DGELLPFKSGAFRLAKEAGVPivPVAISGTWGslpkGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*
gi 560182447 209 YIDGPFFPDSTLTKKEQQKKLHDQV 233
Cdd:cd07989  159 RIGEPIPPEGLELAEEDRKELREKV 183
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-249 2.65e-09

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 55.79  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447  36 IIKHTPLNYLMRFLAAGFAYLFTYgimHVKVIGRDKLFKykNEGYFIYGNHTQMVNDVFMPLTLfgWKNYYAIANQANWG 115
Cdd:COG0204    6 LLLRRFRYRLVRLWARLLLRLLGV---RVRVEGLENLPA--DGPVLIVANHQSWLDILLLLAAL--PRPVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447 116 IPVIGKTLLPYGGLPV-GKNIKQAIKLLKAVKTLTKENAHIVIYPEA------HVWPYYTS-----IRSfpetsfNFPVQ 183
Cdd:COG0204   79 IPLLGWLLRALGAIPVdRSKRRAALRALRQAVEALKAGESLVIFPEGtrspdgRLLPFKTGaarlaLEA------GVPIV 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 560182447 184 ankasfVMTTTY-----QKRKFGKHPKITVYIDGPFFPDStlTKKEQQKKLHDQVFDQLKKRSKNSSYQYY 249
Cdd:COG0204  153 ------PVAIDGteralPKGFLPRPGKVTVRIGPPIDPSD--LEGEDRRELAERLRAAIEALLAELRAEAA 215
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 63-160 2.01e-03

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 37.26  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447   63 HVKVIGRDKLfkYKNEGYFIYGNHTQMVNDVFMPLTLFGWKNYYAIANQANWG-IPVIGKTLLPYGGLPVG-KNIKQAIK 140
Cdd:pfam01553   1 RIEVHGLENL--PRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFdIPLVGWLMRLLGCIFIDrKNRKDAAG 78

                          90       100
                  ....*....|....*....|
gi 560182447  141 LLKAVKTLTKENAHIVIYPE 160
Cdd:pfam01553  79 TLEYLVELLREGKLVVIFPE 98
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 56-160 8.61e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 36.43  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560182447  56 LFTYGIMHVKVIGRDKLfkyKNEGYFIYGNHTQMVNdvfmPLTLFGWKNYYAIANQANWGIPVIGKTLLPYGGLPVG--- 132
Cdd:cd07991    5 LFAFGFYVIKVHGKPDP---PEAPRIIVANHTSFID----PLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDrse 77

                         90       100
                 ....*....|....*....|....*....
gi 560182447 133 -KNIKQAIKLLKAvKTLTKENAHIVIYPE 160
Cdd:cd07991   78 pKDRKKVVEEIKE-RATDPNWPPILIFPE 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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