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Conserved domains on  [gi|648507823|ref|WP_026199574|]
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FmdB family zinc ribbon protein [Lamprocystis purpurea]

Protein Classification

COG2331 family protein( domain architecture ID 10006375)

COG2331 family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
1-78 7.22e-33

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


:

Pssm-ID: 441902  Cd Length: 77  Bit Score: 109.75  E-value: 7.22e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648507823   1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPtLKKQISAAGFRLKGSGWYETDFKQGEKKKNLHGDSEKSDGGG 78
Cdd:COG2331    1 MPIYEYRCESCGHEFEVLQKMSDDPLTVCPECGGP-LRRLISAPGFVFKGSGFYVTDSRSGSKKSSSSSSGSGSSSCG 77
 
Name Accession Description Interval E-value
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
1-78 7.22e-33

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441902  Cd Length: 77  Bit Score: 109.75  E-value: 7.22e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648507823   1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPtLKKQISAAGFRLKGSGWYETDFKQGEKKKNLHGDSEKSDGGG 78
Cdd:COG2331    1 MPIYEYRCESCGHEFEVLQKMSDDPLTVCPECGGP-LRRLISAPGFVFKGSGFYVTDSRSGSKKSSSSSSGSGSSSCG 77
CxxC_CxxC_SSSS TIGR02605
putative regulatory protein, FmdB family; This model represents a region of about 50 amino ...
1-52 9.80e-28

putative regulatory protein, FmdB family; This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions]


Pssm-ID: 274226  Cd Length: 52  Bit Score: 95.87  E-value: 9.80e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 648507823    1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPTLKKQISAAGFRLKGSG 52
Cdd:TIGR02605   1 MPIYEYRCTACGHRFEVLQKMSDDPLATCPACGGTKLRRLLSAAGFALKGSG 52
Zn-ribbon_8 pfam09723
Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number ...
1-41 5.68e-20

Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 462856  Cd Length: 41  Bit Score: 76.10  E-value: 5.68e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 648507823    1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPTLKKQI 41
Cdd:pfam09723   1 MPIYEYRCEECGHEFEVLQKISDPPLTTCPECGSGDVRRLI 41
CxxC_CXXC_SSSS smart00834
Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found ...
1-42 3.55e-18

Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 197903  Cd Length: 41  Bit Score: 71.43  E-value: 3.55e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 648507823     1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPtLKKQIS 42
Cdd:smart00834   1 MPIYEYRCEDCGHTFEVLQKISDDPLTTCPECGGD-VRRLIS 41
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
3-35 7.92e-03

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 34.49  E-value: 7.92e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 648507823   3 IYEYRCTACGHDLEKMQKLADAPLTDCPACGQP 35
Cdd:cd01412  107 LFRVRCSSCGYVGENNEEIPEEELPRCPKCGGL 139
 
Name Accession Description Interval E-value
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
1-78 7.22e-33

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441902  Cd Length: 77  Bit Score: 109.75  E-value: 7.22e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648507823   1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPtLKKQISAAGFRLKGSGWYETDFKQGEKKKNLHGDSEKSDGGG 78
Cdd:COG2331    1 MPIYEYRCESCGHEFEVLQKMSDDPLTVCPECGGP-LRRLISAPGFVFKGSGFYVTDSRSGSKKSSSSSSGSGSSSCG 77
CxxC_CxxC_SSSS TIGR02605
putative regulatory protein, FmdB family; This model represents a region of about 50 amino ...
1-52 9.80e-28

putative regulatory protein, FmdB family; This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions]


Pssm-ID: 274226  Cd Length: 52  Bit Score: 95.87  E-value: 9.80e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 648507823    1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPTLKKQISAAGFRLKGSG 52
Cdd:TIGR02605   1 MPIYEYRCTACGHRFEVLQKMSDDPLATCPACGGTKLRRLLSAAGFALKGSG 52
Zn-ribbon_8 pfam09723
Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number ...
1-41 5.68e-20

Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 462856  Cd Length: 41  Bit Score: 76.10  E-value: 5.68e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 648507823    1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPTLKKQI 41
Cdd:pfam09723   1 MPIYEYRCEECGHEFEVLQKISDPPLTTCPECGSGDVRRLI 41
CxxC_CXXC_SSSS smart00834
Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found ...
1-42 3.55e-18

Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 197903  Cd Length: 41  Bit Score: 71.43  E-value: 3.55e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 648507823     1 MPIYEYRCTACGHDLEKMQKLADAPLTDCPACGQPtLKKQIS 42
Cdd:smart00834   1 MPIYEYRCEDCGHTFEVLQKISDDPLTTCPECGGD-VRRLIS 41
NOB1_Zn_bind pfam08772
Nin one binding (NOB1) Zn-ribbon like; This domain corresponds to a zinc ribbon and is found ...
4-39 2.92e-03

Nin one binding (NOB1) Zn-ribbon like; This domain corresponds to a zinc ribbon and is found on the RNA binding protein NOB1 (Nin one binding).


Pssm-ID: 462597  Cd Length: 72  Bit Score: 34.03  E-value: 2.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 648507823    4 YEYRCTACGHDLEKMQKLAdapltdCPACGQPTLKK 39
Cdd:pfam08772   7 WVLRCHACFKVTKDMTKQF------CPKCGNATLRR 36
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
3-35 7.92e-03

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 34.49  E-value: 7.92e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 648507823   3 IYEYRCTACGHDLEKMQKLADAPLTDCPACGQP 35
Cdd:cd01412  107 LFRVRCSSCGYVGENNEEIPEEELPRCPKCGGL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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