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Conserved domains on  [gi|657907274|ref|WP_029609897|]
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MULTISPECIES: serine hydrolase [Pseudoalteromonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10793 super family cl32580
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 28-383 9.65e-165

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


The actual alignment was detected with superfamily member PRK10793:

Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 467.41  E-value: 9.65e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  28 IIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPE---SS 104
Cdd:PRK10793  37 MIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWATGNPVfkgSS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 105 KMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDAHYTTPRDMAT 184
Cdd:PRK10793 117 LMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMAL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 185 LGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESLDVDGIKTGHTSDAGYSLVTSATKNDMRLIAVVMGTSSERA 264
Cdd:PRK10793 197 IGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKG 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 265 RKVESKKLLNYGFRFFETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELDDT-LEAPLAKGT 343
Cdd:PRK10793 277 RETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNTSeLHAPLQKNQ 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 657907274 344 KVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSKIYDYLRL 383
Cdd:PRK10793 357 VVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKL 396
 
Name Accession Description Interval E-value
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 28-383 9.65e-165

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 467.41  E-value: 9.65e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  28 IIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPE---SS 104
Cdd:PRK10793  37 MIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWATGNPVfkgSS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 105 KMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDAHYTTPRDMAT 184
Cdd:PRK10793 117 LMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMAL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 185 LGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESLDVDGIKTGHTSDAGYSLVTSATKNDMRLIAVVMGTSSERA 264
Cdd:PRK10793 197 IGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKG 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 265 RKVESKKLLNYGFRFFETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELDDT-LEAPLAKGT 343
Cdd:PRK10793 277 RETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNTSeLHAPLQKNQ 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 657907274 344 KVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSKIYDYLRL 383
Cdd:PRK10793 357 VVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKL 396
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
15-376 2.18e-146

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 417.70  E-value: 2.18e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  15 LVCSAAVFSATAQIIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEK 94
Cdd:COG1686    6 LLALLLLLAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTVSEE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  95 AWAKnfpESSKMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDA 174
Cdd:COG1686   86 AART---GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGLPDPG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 175 HYTTPRDMATLGAALIRDVPDEYALYKQKSFTFN---GIKQYNRNSLLWdESLDVDGIKTGHTSDAGYSLVTSATKNDMR 251
Cdd:COG1686  163 HYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLG-RYPGVDGLKTGYTDAAGYCLVASAKRGGRR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 252 LIAVVMGTSSERARKVESKKLLNYGFrffetitpykagdsfaeqrvwmgnkenvslgiledtpitiPRGQhkNLKANFEL 331
Cdd:COG1686  242 LIAVVLGAPSEKARFADAAKLLDYGF----------------------------------------PKGE--ALKAEVVL 279

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 657907274 332 DDTLEAPLAKGTKVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSK 376
Cdd:COG1686  280 DGPLKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
30-258 5.69e-106

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 311.63  E-value: 5.69e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   30 PAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPESSKMFIE 109
Cdd:pfam00768   1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGSSNIFLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  110 VGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDAHYTTPRDMATLGAAL 189
Cdd:pfam00768  81 PGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILAKAL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657907274  190 IRDVPDEYALYKQKSFTF---NGIKQYNRNSLLWDESLDVDGIKTGHTSDAGYSLVTSATKNDMRLIAVVMG 258
Cdd:pfam00768 161 IKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMG 232
PBP4_Staph NF038258
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ...
 34-281 1.28e-40

penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.


Pssm-ID: 468436 [Multi-domain]  Cd Length: 365  Bit Score: 147.05  E-value: 1.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  34 QVNAKGYFLVDfTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEK-AWAKNFPESSKMFIEVGK 112
Cdd:NF038258  37 QYNPEGAIVTT-QTGQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDyEKMSTLPNLSTFPLKPGQ 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 113 QVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDT--------------DAHYTT 178
Cdd:NF038258 116 TYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNnllkpyapkkykdeTKSKST 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 179 PRDMATLGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESL---DVDGIKTGhTSDAGYSLVTSATKNDMRLIAV 255
Cdd:NF038258 196 AKDMAILSQHLIKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQPMslkGTDGLKTG-TSDEGYNLALTTKRDGLRINQV 274

                        250       260       270
                 ....*....|....*....|....*....|..
gi 657907274 256 VMGTS---SERARKVESK---KLLNYGFRFFE 281
Cdd:NF038258 275 IMNVGpypSEGAKHARNKianALMERAFKQYE 306
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 280-370 1.94e-30

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 111.92  E-value: 1.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   280 FETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELD-DTLEAPLAKGTKVGTLFLQLEGEDIA 358
Cdd:smart00936   1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDkPELEAPIKKGQVVGTLVVTLDGKLIG 80

                           90
                   ....*....|..
gi 657907274   359 QYPLVTLEEIQE 370
Cdd:smart00936  81 EVPLVALEDVEK 92
 
Name Accession Description Interval E-value
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 28-383 9.65e-165

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 467.41  E-value: 9.65e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  28 IIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPE---SS 104
Cdd:PRK10793  37 MIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWATGNPVfkgSS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 105 KMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDAHYTTPRDMAT 184
Cdd:PRK10793 117 LMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMAL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 185 LGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESLDVDGIKTGHTSDAGYSLVTSATKNDMRLIAVVMGTSSERA 264
Cdd:PRK10793 197 IGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKG 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 265 RKVESKKLLNYGFRFFETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELDDT-LEAPLAKGT 343
Cdd:PRK10793 277 RETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNTSeLHAPLQKNQ 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 657907274 344 KVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSKIYDYLRL 383
Cdd:PRK10793 357 VVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKL 396
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
26-385 2.04e-161

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 458.69  E-value: 2.04e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  26 AQIIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPE--- 102
Cdd:PRK10001  28 AEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNPAlrg 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 103 SSKMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDAHYTTPRDM 182
Cdd:PRK10001 108 SSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDAPGQFSTARDM 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 183 ATLGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESLDVDGIKTGHTSDAGYSLVTSATKNDMRLIAVVMGTSSE 262
Cdd:PRK10001 188 ALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTD 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 263 RARKVESKKLLNYGFRFFETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELDD-TLEAPLAK 341
Cdd:PRK10001 268 RIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEpQLTAPLKK 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 657907274 342 GTKVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSKIYDYLRLQI 385
Cdd:PRK10001 348 GQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFSRMWDFVMMKF 391
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
15-376 2.18e-146

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 417.70  E-value: 2.18e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  15 LVCSAAVFSATAQIIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEK 94
Cdd:COG1686    6 LLALLLLLAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTVSEE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  95 AWAKnfpESSKMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDA 174
Cdd:COG1686   86 AART---GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGLPDPG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 175 HYTTPRDMATLGAALIRDVPDEYALYKQKSFTFN---GIKQYNRNSLLWdESLDVDGIKTGHTSDAGYSLVTSATKNDMR 251
Cdd:COG1686  163 HYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLG-RYPGVDGLKTGYTDAAGYCLVASAKRGGRR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 252 LIAVVMGTSSERARKVESKKLLNYGFrffetitpykagdsfaeqrvwmgnkenvslgiledtpitiPRGQhkNLKANFEL 331
Cdd:COG1686  242 LIAVVLGAPSEKARFADAAKLLDYGF----------------------------------------PKGE--ALKAEVVL 279

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 657907274 332 DDTLEAPLAKGTKVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSK 376
Cdd:COG1686  280 DGPLKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
dacD PRK11397
serine-type D-Ala-D-Ala carboxypeptidase DacD;
4-385 1.41e-139

serine-type D-Ala-D-Ala carboxypeptidase DacD;


Pssm-ID: 183117 [Multi-domain]  Cd Length: 388  Bit Score: 402.66  E-value: 1.41e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   4 IKHKILTGVCGLVCSAAVFSATAQI--IPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAG 81
Cdd:PRK11397   1 LKRRLIIAASLFAFNLSSAFAAENIpfSPQPPAIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  82 NIAPTDMVTVSEKAWAKN---FPESSKMFIEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIG 158
Cdd:PRK11397  81 RITPDDIVTVGRDAWAKDnpvFVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 159 MTNTHFVNSHGLDTDAHYTTPRDMATLGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESLDVDGIKTGHTSDAG 238
Cdd:PRK11397 161 LKDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 239 YSLVTSATKNDMRLIAVVMGTSSERARKVESKKLLNYGFRFFETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIP 318
Cdd:PRK11397 241 FNLIASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRGKKVGTERIWYGDKENIALGTEQDFWMVLP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 657907274 319 RGQHKNLKANFELD-DTLEAPLAKGTKVGTLFLQLEGEDIAQYPLVTLEEIQEGSFFSKIYDYLRLQI 385
Cdd:PRK11397 321 KAEIPHIKAKYVLDgKELEAPISAHQRVGEIELYDRDKQVAHWPLVTLESVGEGGMFSRLSDYFHHKA 388
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
30-258 5.69e-106

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 311.63  E-value: 5.69e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   30 PAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPESSKMFIE 109
Cdd:pfam00768   1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGSSNIFLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  110 VGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDTDAHYTTPRDMATLGAAL 189
Cdd:pfam00768  81 PGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILAKAL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657907274  190 IRDVPDEYALYKQKSFTF---NGIKQYNRNSLLWDESLDVDGIKTGHTSDAGYSLVTSATKNDMRLIAVVMG 258
Cdd:pfam00768 161 IKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMG 232
PBP4_Staph NF038258
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ...
 34-281 1.28e-40

penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.


Pssm-ID: 468436 [Multi-domain]  Cd Length: 365  Bit Score: 147.05  E-value: 1.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  34 QVNAKGYFLVDfTTGKVIAQGEADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEK-AWAKNFPESSKMFIEVGK 112
Cdd:NF038258  37 QYNPEGAIVTT-QTGQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDyEKMSTLPNLSTFPLKPGQ 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 113 QVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMNAHAEKIGMTNTHFVNSHGLDT--------------DAHYTT 178
Cdd:NF038258 116 TYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNnllkpyapkkykdeTKSKST 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 179 PRDMATLGAALIRDVPDEYALYKQKSFTFNGIKQYNRNSLLWDESL---DVDGIKTGhTSDAGYSLVTSATKNDMRLIAV 255
Cdd:NF038258 196 AKDMAILSQHLIKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQPMslkGTDGLKTG-TSDEGYNLALTTKRDGLRINQV 274

                        250       260       270
                 ....*....|....*....|....*....|..
gi 657907274 256 VMGTS---SERARKVESK---KLLNYGFRFFE 281
Cdd:NF038258 275 IMNVGpypSEGAKHARNKianALMERAFKQYE 306
PBP5_C pfam07943
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 280-370 8.18e-32

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 429749 [Multi-domain]  Cd Length: 91  Bit Score: 115.38  E-value: 8.18e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  280 FETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELDDTLEAPLAKGTKVGTLFLQLEGEDIAQ 359
Cdd:pfam07943   1 FETKKLYKKGDVVKKVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTLKKPLEAPIKKGQVVGKLEVYLDGKLIGE 80

                          90
                  ....*....|.
gi 657907274  360 YPLVTLEEIQE 370
Cdd:pfam07943  81 VPLVAKEDVEE 91
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 280-370 1.94e-30

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 111.92  E-value: 1.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   280 FETITPYKAGDSFAEQRVWMGNKENVSLGILEDTPITIPRGQHKNLKANFELD-DTLEAPLAKGTKVGTLFLQLEGEDIA 358
Cdd:smart00936   1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDkPELEAPIKKGQVVGTLVVTLDGKLIG 80

                           90
                   ....*....|..
gi 657907274   359 QYPLVTLEEIQE 370
Cdd:smart00936  81 EVPLVALEDVEK 92
pbpG PRK11669
D-alanyl-D-alanine endopeptidase; Provisional
 1-256 7.72e-18

D-alanyl-D-alanine endopeptidase; Provisional


Pssm-ID: 236952  Cd Length: 306  Bit Score: 83.19  E-value: 7.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   1 MKsIKHKILTgvCGLVCSAAVFSATA-------QIIPAPPQVNAKGYFLVDFTTGKVIAQGEADTKLAPASLTKMMTSYV 73
Cdd:PRK11669   1 MK-FRVSLLS--LLLLLAGVPFAPQAvaktaaaTTASQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  74 IgteINAgNIAPTDMVTVSekawAKNFPESSKMF--IEVGKQVSVDDLNHGIIIQSGNDACVAMAEHIAGSESAFADLMN 151
Cdd:PRK11669  78 V---LDA-KLPLDEKLKVD----ISQTPEMKGVYsrVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMN 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274 152 AHAEKIGMTNTHFVNSHGLDTDaHYTTPRDMATLGAAlIRDVP--DEYALYKQKSFTFNGIKQ----YNRNSLLWDESLD 225
Cdd:PRK11669 150 AKAKALGMTNTRYVEPTGLSIH-NVSTARDLTKLLIA-SKQYPliGQLSTTREKTATFRKPNYtlpfRNTNHLVYRDNWN 227

                        250       260       270
                 ....*....|....*....|....*....|.
gi 657907274 226 VDGIKTGHTSDAGYSLVTSaTKNDMRLIAVV 256
Cdd:PRK11669 228 IQLTKTGFTNAAGHCLVMR-TVINNRPVALV 257
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
39-192 1.62e-10

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 61.07  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  39 GYFLVDFTTGKVIAQGeADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAKNFPESSKMfiEVGKQVSVDD 118
Cdd:COG2367   36 GVYVLDLDTGETVGIN-ADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTPEDLVGGSGILQKL--PDGTGLTLRE 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657907274 119 LNHGIIIQSGNDACVAMAEHIAGSEsafadlMNAHAEKIGMTNTHFVNS----HGLDTDA-HYTTPRDMATLGAALIRD 192
Cdd:COG2367  113 LAELMITVSDNTATNLLLRLLGPDA------VNAFLRSLGLTDTRLDRKepdlNELPGDGrNTTTPRDMARLLAALYRG 185
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
 39-192 7.66e-09

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 55.36  E-value: 7.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274   39 GYFLVDFTTGKVIAQGeADTKLAPASLTKMMTSYVIGTEINAGNIAPTDMVTVSEKAWAknfPESSKM-FIEVGKQVSVD 117
Cdd:pfam13354   1 GIYVRDLDTGEELGIN-GDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAEDKV---GGSGILqYLPDGSQLSLR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657907274  118 DLNHGIIIQSGNDACVAMAEHIAGSEsafadlMNAHAEKIGMTNTHFVN-----SHGLDTDAHYTTPRDMATLGAALIRD 192
Cdd:pfam13354  77 DLLTLMIAVSDNTATNLLIDRLGLEA------VNARLRALGLRDTRLRRklpdlRAADKGGTNTTTARDMAKLLEALYRG 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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