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Conserved domains on  [gi|685999406|ref|WP_031702567|]
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UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [Mycobacterium tuberculosis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
murD super family cl36818
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 10-483 9.71e-139

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


The actual alignment was detected with superfamily member TIGR01087:

Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 406.34  E-value: 9.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   10 PVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA-----VQQITGYALVVASPGFSPAIPLLA 84
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLhtglhLEDLNNADLVVKSPGIPPDHPLVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   85 AAAAAGVPIWGDVELAWRLdaagcygPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLD-EPAELL 163
Cdd:TIGR01087  81 AAAKRGIPVVGDIELFLRL-------VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELY 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  164 AVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLT----GGVAVAGLDDSRAAALLDGSPAQVRVGF 239
Cdd:TIGR01087 154 VLELSSFQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFArqteGDVAVLNADDPRFARLAQKSKAQVIWFS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  240 RLGEpAAGELGVRDAHLVDRAFSddltllpvASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVA 319
Cdd:TIGR01087 234 VEKD-AERGLCIRDGGLYLKPND--------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  320 VADGITYVDDSKATNPHAARASVLAYPR-VVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPV 398
Cdd:TIGR01087 305 QKNGVHFYNDSKATNVHATLAALSAFDNpVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVYL 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  399 VqvvagedtgmpAAVEVPVACVLDVAkddkagetvgaavmtaavaaarrmaQPGDTVLLAPAGASFDQFTGYADRGEAFA 478
Cdd:TIGR01087 385 V-----------ESLEEAVQAAREVA-------------------------SPGDVVLLSPACASFDQFKSYEERGEKFK 428


                  ....*
gi 685999406  479 TAVRA 483
Cdd:TIGR01087 429 ELVRA 433
 
Name Accession Description Interval E-value
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 10-483 9.71e-139

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 406.34  E-value: 9.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   10 PVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA-----VQQITGYALVVASPGFSPAIPLLA 84
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLhtglhLEDLNNADLVVKSPGIPPDHPLVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   85 AAAAAGVPIWGDVELAWRLdaagcygPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLD-EPAELL 163
Cdd:TIGR01087  81 AAAKRGIPVVGDIELFLRL-------VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELY 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  164 AVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLT----GGVAVAGLDDSRAAALLDGSPAQVRVGF 239
Cdd:TIGR01087 154 VLELSSFQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFArqteGDVAVLNADDPRFARLAQKSKAQVIWFS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  240 RLGEpAAGELGVRDAHLVDRAFSddltllpvASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVA 319
Cdd:TIGR01087 234 VEKD-AERGLCIRDGGLYLKPND--------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  320 VADGITYVDDSKATNPHAARASVLAYPR-VVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPV 398
Cdd:TIGR01087 305 QKNGVHFYNDSKATNVHATLAALSAFDNpVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVYL 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  399 VqvvagedtgmpAAVEVPVACVLDVAkddkagetvgaavmtaavaaarrmaQPGDTVLLAPAGASFDQFTGYADRGEAFA 478
Cdd:TIGR01087 385 V-----------ESLEEAVQAAREVA-------------------------SPGDVVLLSPACASFDQFKSYEERGEKFK 428


                  ....*
gi 685999406  479 TAVRA 483
Cdd:TIGR01087 429 ELVRA 433
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 8-483 3.32e-133

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 392.52  E-value: 3.32e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   8 GAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAE---RGLPTVSSSDAVQQITGYALVVASPGFSPAIPLLA 84
Cdd:COG0771    4 GKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAAEleaPGVEVVLGEHPEELLDGADLVVKSPGIPPDHPLLK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  85 AAAAAGVPIWGDVELAWRLdaagcygPPRSWL----------VVtgtngkttttSMLHAMLIAGGRRAVLCGNIGSAVLD 154
Cdd:COG0771   84 AARAAGIPVIGEIELAYRL-------SPAPIIaitgtngkttTT----------TLIGHILKAAGLRVAVGGNIGTPLLD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 155 VLDE--PAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTG----GVAVAGLDDSRAAALL 228
Cdd:COG0771  147 LLLEpePPDVYVLELSSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANqtpdDYAVLNADDPLTRALA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 229 DGSPAQVrVGFRLGEPAAGELGVRDAHLVDRAfsDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSF 308
Cdd:COG0771  227 EEAKARV-VPFSLKEPLEGGAGLEDGKLVDRA--SGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSF 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 309 RVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYP-RVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAE 387
Cdd:COG0771  304 KGLPHRLEFVAEINGVRFINDSKATNPDATLAALESFDgPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAA 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 388 ALSRHApdVPVVQVvageDTgMPAAVEvpvacvldVAKDDkagetvgaavmtaavaaarrmAQPGDTVLLAPAGASFDQF 467
Cdd:COG0771  384 ALAGAG--VPVVIV----ET-MEEAVA--------AAAEL---------------------ARPGDVVLLSPACASFDQF 427

                        490
                 ....*....|....*.
gi 685999406 468 TGYADRGEAFATAVRA 483
Cdd:COG0771  428 KNYEERGDVFKEAVRE 443
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 11-482 1.14e-62

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 210.60  E-value: 1.14e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  11 VLVAGGRVTGQAVAAVLTRFGATPTVCD----DDPvmlrphaERGLPTVSSSDaVQQITG---------YALVVASPGFS 77
Cdd:PRK14106   8 VLVVGAGVSGLALAKFLKKLGAKVILTDekeeDQL-------KEALEELGELG-IELVLGeypeeflegVDLVVVSPGVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  78 PAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGpprswlvVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLD 157
Cdd:PRK14106  80 LDSPPVVQAHKKGIEVIGEVELAYRFSKAPIVA-------ITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIDAVE 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 158 EPAE--LLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLT----GGVAVAGLDDSRAAALLDGS 231
Cdd:PRK14106 153 EYGEddIIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFEnqrpSDYTVLNYDDPRTRSLAKKA 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 232 PAQVRVGFRLGEPAAGeLGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311
Cdd:PRK14106 233 KARVIFFSRKSLLEEG-VFVKNGKIVISLGGKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPR-VVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALS 390
Cdd:PRK14106 312 EHRIEFVAEINGVKFINDSKGTNPDAAIKALEAYETpIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAAR 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 391 RHAPDVpVVQVvagedTGMPAAVEvpvacvldvakddKAGETvgaavmtaavaaarrmAQPGDTVLLAPAGASFDQFTGY 470
Cdd:PRK14106 392 KYGFDN-ILFA-----ETLEEAVK-------------KAYEI----------------AKPGDVVLLSPACASWDMFKNF 436

                        490
                 ....*....|..
gi 685999406 471 ADRGEAFATAVR 482
Cdd:PRK14106 437 EERGRLFKELVL 448
Mur_ligase_M pfam08245
Mur ligase middle domain;
129-234 7.97e-11

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 61.17  E-value: 7.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  129 SMLHAMLIAGGRRAVLCGN------------IG--SAVLDVLDEPAELLAVELSSFQLHWAPS---LRPEAGAVLNIAED 191
Cdd:pfam08245  12 ELIAAILSLAGGVIGTIGTyigksgnttnnaIGlpLTLAEMVEAGAEYAVLEVSSHGLGEGRLsglLKPDIAVFTNISPD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 685999406  192 HLDWHATMAEYTAAKARVLTG----GVAVAGLDDSRAAALLDGSPAQ 234
Cdd:pfam08245  92 HLDFHGTMENYAKAKAELFEGlpedGIAVINADDPYGAFLIAKLKKA 138
 
Name Accession Description Interval E-value
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 10-483 9.71e-139

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 406.34  E-value: 9.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   10 PVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA-----VQQITGYALVVASPGFSPAIPLLA 84
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLhtglhLEDLNNADLVVKSPGIPPDHPLVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   85 AAAAAGVPIWGDVELAWRLdaagcygPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLD-EPAELL 163
Cdd:TIGR01087  81 AAAKRGIPVVGDIELFLRL-------VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELY 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  164 AVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLT----GGVAVAGLDDSRAAALLDGSPAQVRVGF 239
Cdd:TIGR01087 154 VLELSSFQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFArqteGDVAVLNADDPRFARLAQKSKAQVIWFS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  240 RLGEpAAGELGVRDAHLVDRAFSddltllpvASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVA 319
Cdd:TIGR01087 234 VEKD-AERGLCIRDGGLYLKPND--------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  320 VADGITYVDDSKATNPHAARASVLAYPR-VVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPV 398
Cdd:TIGR01087 305 QKNGVHFYNDSKATNVHATLAALSAFDNpVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVYL 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  399 VqvvagedtgmpAAVEVPVACVLDVAkddkagetvgaavmtaavaaarrmaQPGDTVLLAPAGASFDQFTGYADRGEAFA 478
Cdd:TIGR01087 385 V-----------ESLEEAVQAAREVA-------------------------SPGDVVLLSPACASFDQFKSYEERGEKFK 428


                  ....*
gi 685999406  479 TAVRA 483
Cdd:TIGR01087 429 ELVRA 433
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 8-483 3.32e-133

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 392.52  E-value: 3.32e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   8 GAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAE---RGLPTVSSSDAVQQITGYALVVASPGFSPAIPLLA 84
Cdd:COG0771    4 GKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAAEleaPGVEVVLGEHPEELLDGADLVVKSPGIPPDHPLLK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  85 AAAAAGVPIWGDVELAWRLdaagcygPPRSWL----------VVtgtngkttttSMLHAMLIAGGRRAVLCGNIGSAVLD 154
Cdd:COG0771   84 AARAAGIPVIGEIELAYRL-------SPAPIIaitgtngkttTT----------TLIGHILKAAGLRVAVGGNIGTPLLD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 155 VLDE--PAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTG----GVAVAGLDDSRAAALL 228
Cdd:COG0771  147 LLLEpePPDVYVLELSSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANqtpdDYAVLNADDPLTRALA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 229 DGSPAQVrVGFRLGEPAAGELGVRDAHLVDRAfsDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSF 308
Cdd:COG0771  227 EEAKARV-VPFSLKEPLEGGAGLEDGKLVDRA--SGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSF 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 309 RVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYP-RVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAE 387
Cdd:COG0771  304 KGLPHRLEFVAEINGVRFINDSKATNPDATLAALESFDgPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAA 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 388 ALSRHApdVPVVQVvageDTgMPAAVEvpvacvldVAKDDkagetvgaavmtaavaaarrmAQPGDTVLLAPAGASFDQF 467
Cdd:COG0771  384 ALAGAG--VPVVIV----ET-MEEAVA--------AAAEL---------------------ARPGDVVLLSPACASFDQF 427

                        490
                 ....*....|....*.
gi 685999406 468 TGYADRGEAFATAVRA 483
Cdd:COG0771  428 KNYEERGDVFKEAVRE 443
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 11-482 1.14e-62

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 210.60  E-value: 1.14e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  11 VLVAGGRVTGQAVAAVLTRFGATPTVCD----DDPvmlrphaERGLPTVSSSDaVQQITG---------YALVVASPGFS 77
Cdd:PRK14106   8 VLVVGAGVSGLALAKFLKKLGAKVILTDekeeDQL-------KEALEELGELG-IELVLGeypeeflegVDLVVVSPGVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  78 PAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGpprswlvVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLD 157
Cdd:PRK14106  80 LDSPPVVQAHKKGIEVIGEVELAYRFSKAPIVA-------ITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIDAVE 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 158 EPAE--LLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLT----GGVAVAGLDDSRAAALLDGS 231
Cdd:PRK14106 153 EYGEddIIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFEnqrpSDYTVLNYDDPRTRSLAKKA 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 232 PAQVRVGFRLGEPAAGeLGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVG 311
Cdd:PRK14106 233 KARVIFFSRKSLLEEG-VFVKNGKIVISLGGKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 312 RHRAEVVAVADGITYVDDSKATNPHAARASVLAYPR-VVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALS 390
Cdd:PRK14106 312 EHRIEFVAEINGVKFINDSKGTNPDAAIKALEAYETpIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAAR 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 391 RHAPDVpVVQVvagedTGMPAAVEvpvacvldvakddKAGETvgaavmtaavaaarrmAQPGDTVLLAPAGASFDQFTGY 470
Cdd:PRK14106 392 KYGFDN-ILFA-----ETLEEAVK-------------KAYEI----------------AKPGDVVLLSPACASWDMFKNF 436

                        490
                 ....*....|..
gi 685999406 471 ADRGEAFATAVR 482
Cdd:PRK14106 437 EERGRLFKELVL 448
Mur_ligase_M pfam08245
Mur ligase middle domain;
129-234 7.97e-11

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 61.17  E-value: 7.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  129 SMLHAMLIAGGRRAVLCGN------------IG--SAVLDVLDEPAELLAVELSSFQLHWAPS---LRPEAGAVLNIAED 191
Cdd:pfam08245  12 ELIAAILSLAGGVIGTIGTyigksgnttnnaIGlpLTLAEMVEAGAEYAVLEVSSHGLGEGRLsglLKPDIAVFTNISPD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 685999406  192 HLDWHATMAEYTAAKARVLTG----GVAVAGLDDSRAAALLDGSPAQ 234
Cdd:pfam08245  92 HLDFHGTMENYAKAKAELFEGlpedGIAVINADDPYGAFLIAKLKKA 138
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 175-396 6.74e-10

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 61.64  E-value: 6.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 175 APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVL----TGGVAVAGLDDSRAAALLDGSPAQV--RVGFRLGEPAAGE 248
Cdd:PRK11929 677 AAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIaalpEDGVAVVNGDDPYTAIWAKLAGARRvlRFGLQPGADVYAE 756

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 249 LGVRDAHLVDRAFSDDLTLLPVASIPVPGPV----GVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGI 324
Cdd:PRK11929 757 KIAKDISVGEAGGTRCQVVTPAGSAEVYLPLigehNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGT 836

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 325 TYVDDSKATNPHAARASV-----LAYPRVVWIAGGLLK----GASLHAEVAAMASRL-VGAVLI-GRDRAAVAEALSRHA 393
Cdd:PRK11929 837 RIIDDTYNANPDSMRAAIdvlaeLPNGPRALVLGDMLElgdnGPAMHREVGKYARQLgIDALITlGEAARDAAAAFGAGA 916


                 ...
gi 685999406 394 PDV 396
Cdd:PRK11929 917 RGV 919
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 179-396 2.92e-08

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 55.88  E-value: 2.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 179 RPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTG----GVAVAGLDDSRAAALLDGSPAQVrVGFRLGEPAAgelgVRDA 254
Cdd:COG0770  175 RPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGlppgGVAVLNADDPLLAALAERAKARV-LTFGLSEDAD----VRAE 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 255 HLVDRAFSDDLTL------LPVaSIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVD 328
Cdd:COG0770  250 DIELDEDGTRFTLhtpggeLEV-TLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLID 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 329 DS-KAtNPHAARAS--VLA----YPRVVWIAGGLL----KGASLHAEVAAMASRLV--GAVLIGRDRAAVAEAL----SR 391
Cdd:COG0770  329 DSyNA-NPDSMKAAldVLAqlpgGGRRIAVLGDMLelgeESEELHREVGELAAELGidRLFTVGELARAIAEAAggerAE 407


                 ....*
gi 685999406 392 HAPDV 396
Cdd:COG0770  408 HFEDK 412
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 312-378 4.22e-08

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 50.42  E-value: 4.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 685999406  312 RHRAEVVAVADGITYVDDsKATNPHAARASV-----LAYPRVVWIAGGLL-KGASLHAEVAAMASRLVGAVLI 378
Cdd:pfam02875   2 PGRLEVVGENNGVLVIDD-YAHNPDAMEAALralrnLFPGRLILVFGGMGdRDAEFHALLGRLAAALADVVIL 73
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 178-328 1.31e-07

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 53.93  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 178 LRPEAGAVLNIAEDHLDWHATMAEYTAAKAR----VLTGGVAVAGLDDSRAAALLDGSPAQVrVGFRLGEPAagelgvrD 253
Cdd:COG0769  168 VRFDVAVFTNLTRDHLDYHGTMEAYFAAKARlfdqLGPGGAAVINADDPYGRRLAAAAPARV-ITYGLKADA-------D 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 254 AHLVDRAFSDDLTLLPVAS--------IPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGIT 325
Cdd:COG0769  240 LRATDIELSADGTRFTLVTpggevevrLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQGPT 319


                 ....
gi 685999406 326 -YVD 328
Cdd:COG0769  320 vIVD 323
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 181-328 1.50e-07

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 53.60  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 181 EAGAVLNIAEDHLDWHATMAEYTAAKARVLT--GGVAVAGLDDSRAAALLDGSPAqvrvgFRLGEPAAgelgvrDAHLVD 258
Cdd:PRK00139 186 DVAVFTNLSRDHLDYHGTMEDYLAAKARLFSelGLAAVINADDEVGRRLLALPDA-----YAVSMAGA------DLRATD 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 685999406 259 RAFSDD---LTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGIT-YVD 328
Cdd:PRK00139 255 VEYTDSgqtFTLVTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQGPLvIVD 328
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 126-329 1.16e-06

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 50.84  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 126 TTTSMLHAMLIAGGRRA-VLCGnigsAVLDVLDEPA-----ELLAVE----LSSFqLHwapsLRPEAGAVLNIAEDHLDW 195
Cdd:COG0773  117 TTTSMLAHILEEAGLDPtFLIG----GILNNFGTNArlgdgDYFVAEadesDGSF-LH----YSPDIAVVTNIEADHLDI 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 196 HATMAEYTAA----KARVLTGGVAVAGLDDSRAAALLDGSPAQVRvgfRLGEPAAGELGVRDAHLVDRAFS-----DDLT 266
Cdd:COG0773  188 YGDLEAIKEAfhefARNVPFYGLLVLCADDPGLRELLPRCGRPVI---TYGFSEDADYRAENIRIDGGGSTfdvlrRGEE 264

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 685999406 267 LLPVaSIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFR-VGRhRAEVVAVADGITYVDD 329
Cdd:COG0773  265 LGEV-ELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKgVKR-RFELKGEVGGVTVIDD 326
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 154-324 1.24e-06

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 51.24  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 154 DVLDEPAELLAVELSSFQL--HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTG----GVAVAGLDDSRAAAL 227
Cdd:PRK11929 174 RMRAAGADAVAMEASSHGLeqGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKlpglGAAVINADDPAAARL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406 228 LDGSPAQVRVGFRLGEPAAgelGVRDAHLVDRAFSDDLTL-LPVAS----IPVPGPVGVLDALAAAALARSVGVPAGAIA 302
Cdd:PRK11929 254 LAALPRGLKVGYSPQNAGA---DVQARDLRATAHGQVFTLaTPDGSyqlvTRLLGRFNVSNLLLVAAALKKLGLPLAQIA 330

                        170       180
                 ....*....|....*....|..
gi 685999406 303 DAVTSFRVGRHRAEVVAVADGI 324
Cdd:PRK11929 331 RALAAVSPVPGRMERVGPTAGA 352
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 160-233 3.59e-05

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 46.16  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  160 AELLAVELSSFQL--HWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLT----GGVAVAGLDDSRAAALLDGSPA 233
Cdd:TIGR01085 156 AQYAVMEVSSHALaqGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTelglKRFAVINLDDEYGAQFVKRLPK 235
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 62-329 2.25e-04

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 43.45  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406   62 QQITGYALVVASPGFSPAIPLLAAAAAAGVPIWGdvelawRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRR 141
Cdd:TIGR01082  54 ENLDDADVVVVSAAIKDDNPEIVEAKERGIPVIR------RAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLD 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  142 --AVLCGNIGSAVLDVLDEPAELLAVEL----SSFqLHwapsLRPEAGAVLNIAEDHLDWH-ATMAEYTAAKARVLT--- 211
Cdd:TIGR01082 128 ptVVVGGLVKEAGTNARLGSGEYLVAEAdesdASF-LH----LQPNVAIVTNIEPDHLDTYgSSFERLKAAFEKFIHnlp 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685999406  212 -GGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAagelgvrDAHLVDRAFSDD---------LTLLPVASIPVPGPVGV 281
Cdd:TIGR01082 203 fYGLAVICADDPVLRELVPKATEQVITYGGSGEDA-------DYRAENIQQSGAegkfsvrgkGKLYLEFTLNLPGRHNV 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 685999406  282 LDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDD 329
Cdd:TIGR01082 276 LNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGGVLLIDD 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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