|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
14-466 |
9.93e-138 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 404.50 E-value: 9.93e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:PRK10504 13 WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:PRK10504 93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 174 IGIAGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVLFSsgIELFGEK---IVASWIALtVIVTSIGLLLLYILHARRTP 250
Cdd:PRK10504 173 VGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLT--LALDGSKglgLSPLAIAG-LVAVGVVALLLYLLHARNNN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 251 NPLISLDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHT 330
Cdd:PRK10504 250 RALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 331 LVGITVIIGLMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVS 410
Cdd:PRK10504 330 LVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIA 409
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 411 AAVLRVYE----GMEGTTTVEQFHYTFITMGIITVASAAMFMLLKTTDGNNLIKRQRKSK 466
Cdd:PRK10504 410 GLLLGLFGqqhvSVDSGATHTVFMYTYLCMALIIALPALIFARVPNDTHQNVAISRRKRS 469
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
16-451 |
2.03e-102 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 311.05 E-value: 2.03e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 16 AAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACAL 95
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 96 SNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIG 175
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 176 IAGLLYAhkhmpnfttarrrfdttgfllfglslvlfssgielfgekivaswialtvivtsigllllyilharrtpnPLIS 255
Cdd:cd17503 161 ILALLLA---------------------------------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 256 LDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGIT 335
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 336 VIIGLMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVLR 415
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 693049541 416 VYEGMEGTTTVEQ-------------FHYTFITMGIITVASAAMFMLLK 451
Cdd:cd17503 332 NRTQFHHSRLSELlaqqvqkqaliiaFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
18-449 |
7.57e-70 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 229.96 E-value: 7.57e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 18 MAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSN 97
Cdd:TIGR00711 9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 98 SLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIA 177
Cdd:TIGR00711 89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 178 GLLYAHKHMPNFT-TARRRFDTTGFLLFGLSLVLFSSGIELFGEK-IVASWIALTVIVTSIGLLLLYILHARRTPNPLIS 255
Cdd:TIGR00711 169 VVVVAFFILPRDKpAASENFDFLGLLLLSVGLGSLLYGLSEGPERgWFDSNEILILSITGLVAIIAFVVWELTDDNPLVD 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 256 LDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGIT 335
Cdd:TIGR00711 249 LRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 336 VIIGLMIAQFSLQ-SPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVL 414
Cdd:TIGR00711 329 ILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTIL 408
|
410 420 430
....*....|....*....|....*....|....*
gi 693049541 415 rvyegmegtTTVEQFHYTFITMGIITVASAAMFML 449
Cdd:TIGR00711 409 ---------TNRTQFHHSQLTETINPVNPNFLSGY 434
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-451 |
6.62e-55 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 187.38 E-value: 6.62e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 17 AMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALS 96
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 97 NSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGI 176
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 177 AGLLYAhkhmpnfttarrrfdttgfllfglslvlfssgielfgekivaswialtvivtsigllllyilharrtpnplisl 256
Cdd:cd17321 162 VALLLA-------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 257 dlfktRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITV 336
Cdd:cd17321 168 -----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 337 IIGLMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVL-R 415
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLtA 322
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 693049541 416 VYEGMEGTTTVEQ------------FHYTFITMGIITVASAAMFMLLK 451
Cdd:cd17321 323 GLSANLGDSGVAAllsaaaaafaagFHLAFLVAAALALLAALLALLLP 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-405 |
1.66e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.58 E-value: 1.66e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 6 KRSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSL 85
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 86 FTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWH 165
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 166 WIFLINIPIGIAGLLYAHKHMPNFTTARRRFDTTGFllfglslvlfssgielfgekivaswialtvivtsigllllyilh 245
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 246 arrtpnplisLDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRL 325
Cdd:COG2814 201 ----------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 326 GYRHTLVGITVIIGLMIAQFSLqspAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISL 405
Cdd:COG2814 271 GRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-412 |
6.71e-36 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 135.77 E-value: 6.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 18 MAFFMQALDATILNTALPAIAHSLNRSPLaMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSN 97
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 98 SLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGia 177
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 178 gllyahkhmpnfttarrrfdttgfllfGLSLVLFSSgielfgekivaSWIALTVIVTSIGLLLLYIlharrtpnplisld 257
Cdd:cd17502 160 ---------------------------GLALALLRT-----------ILLSSIFGFLFGGALFGLI-------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 258 lfktrtfsigivsniatrlgtgcvpFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLG-YRHTLVGITV 336
Cdd:cd17502 188 -------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 693049541 337 IIGLMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAA 412
Cdd:cd17502 243 LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDV 318
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-246 |
4.84e-35 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 132.24 E-value: 4.84e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 1 MSDKKKRSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFT 80
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 81 LAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVT 160
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 161 WATWHWIFLINIPIGIAGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVLFSSGIELFGEKIVASWIALTVIVTSIGLLL 240
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
....*.
gi 693049541 241 LYILHA 246
Cdd:COG0477 244 ALLLLA 249
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-451 |
1.22e-28 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 116.14 E-value: 1.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 17 AMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALS 96
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 97 NSLPQLVVFRVIQGIGGAmMMPVArLALLRAYPRNELLPV-LNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIG 175
Cdd:cd17504 82 PNLPVLIAGRALQGIGGA-VFPLA-FALVREEFPPERVPVaQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 176 IAGLLYAhkhmpnfttarrrfdttgfllfglslvlfssgielfgekivaswialtvivtsigllllyilharrtpnPLIS 255
Cdd:cd17504 160 VLLAALV---------------------------------------------------------------------PLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 256 LDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQ----VGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTL 331
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 332 VG--ITVIIGLMIAQFSLQSpamaIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAV 409
Cdd:cd17504 251 LIglVISAVGLLLLALLHSS----LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAI 326
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 693049541 410 SAAVL---RVYEGMEGTTTVEQFHYTFITMGIITVASAAMFMLLK 451
Cdd:cd17504 327 AGAILttyTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-406 |
3.42e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.04 E-value: 3.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 17 AMAFFMQALDATILNTALP-AIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACAL 95
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 96 SNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIG 175
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 176 IAGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVLFSSGIELfgekivasWIALTVIVTSIGLLLLYilharrtpnplis 255
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL--------WLLLALLLFGFAFFGLL------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 256 ldlfktrtfsigivsniatrlgtgcvpFLMPLMLQVgFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGIT 335
Cdd:pfam07690 221 ---------------------------TYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 693049541 336 VIIGLMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLG 406
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
24-409 |
6.55e-26 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 110.20 E-value: 6.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 24 ALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLV 103
Cdd:PRK14995 19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 104 VFRVIQGIGGAMMMPVA----RLALLRAYPRNELLPVLNFVampGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGL 179
Cdd:PRK14995 99 ATRALLAIGAAMIVPATlagiRATFTEEKQRNMALGVWAAV---GSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVM 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 180 LYAHKHMPnfTTARRRFDTTGF-----LLFGLSLVLFSSGIELFGEkiVASWIALTVIVTSIGLLLLYILHARRTPNPLI 254
Cdd:PRK14995 176 GLTARYVP--RQAGRRDQPLNLghalmLIVAILLLVYSAKTALKGF--LSLWVTSLTLLTGALLLGLFIRTQLAASRPMI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 255 SLDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGI 334
Cdd:PRK14995 252 DMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 335 TVI-----IGLMIAQFSLQSPAMAIWMLilplfILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAV 409
Cdd:PRK14995 332 MALsalsfYGLAMTDFSTQQWQAWGLMA-----LLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAI 406
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-411 |
2.27e-25 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 107.28 E-value: 2.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 12 LPWIAAMAFFMQaLDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSL 91
Cdd:cd17320 1 LLLLALLVALGP-LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 92 ACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLIn 171
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 172 ipigiagllyahkhmpnfttarrrfdttgflLFGLSLVLFssgielfgekiVASWIAL--TVIVTSIGLLLLYILHARRT 249
Cdd:cd17320 159 -------------------------------LALLGLLLL-----------LLVLLFLpeTLPEEKRKPLLSSLLRAYKR 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 250 pnplisldLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRH 329
Cdd:cd17320 197 --------VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 330 TL---VGITVIIGLMIAQFSLQSPaMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDnASSGNSVLAVTQQLSISLG 406
Cdd:cd17320 269 LLrlgLLLLLAAALVLLLAALLGG-LSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHV-AGTASALLGFLQFLIGALA 346
|
....*
gi 693049541 407 VAVSA 411
Cdd:cd17320 347 GALVG 351
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-378 |
3.37e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 94.94 E-value: 3.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWAtWHWIFL---I 170
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPFFllaA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 171 NIPIGIAGLLYAHKHMPNFTTArrrfdttgfllfglslvlfSSGIELFGEKIVASWIALTVIVTSiGLLLLYILharrtp 250
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKS-------------------SSATKLRDLKKALRGRGLLTFLVS-AFLYFFLY------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 251 nplisldlfktrtfsigivsniatrlgtGCVPFLMPLMLQVGFGYQAFIAGCMMAP----TALGSIIAKSMVTqvlRRLG 326
Cdd:cd17474 215 ----------------------------FAFLTYLPFLLELLYGISPIIIGLLFAGwsvlLALGSLFVGRLLK---KRFG 263
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 693049541 327 YRHTLVGITViigLMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTI 378
Cdd:cd17474 264 ARRILVIGLL---LYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
|
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
21-215 |
1.55e-20 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 93.88 E-value: 1.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 21 FMQALDATILNTALPAIAHSLN-RSPLAMQSAIisYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSL 99
Cdd:NF040895 16 FMAAIETSIISLALPTIKEDLNaGSSISLVFTV--YFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSETF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 100 PQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGI--A 177
Cdd:NF040895 94 TMLIISRIIQGLGAGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFFINIPIAIiaI 173
|
170 180 190
....*....|....*....|....*....|....*....
gi 693049541 178 GLLYAHKHMPN-FTTARRRFDTTGFLLFGLSLVLFSSGI 215
Cdd:NF040895 174 ILVIFTFHFPEeETTSKTKFDVKGLTLFYIFIALLMFAV 212
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-182 |
1.28e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.93 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
....*....
gi 693049541 174 IGIAGLLYA 182
Cdd:COG2271 173 PGLLLALLR 181
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
15-413 |
7.73e-19 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 87.70 E-value: 7.73e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACA 94
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 95 LSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYP----RNEllpVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLI 170
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPpgprKNI---VFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 171 NipigiAGLLyahkhmpnfttarrrfdttgFLLFGLSLVLFSSgielfgeKIVASWIALTVIVTSIGLLLLYIlharrtp 250
Cdd:cd17476 159 L-----AILA--------------------AIVAVAAIFWTSP-------SFIAVLLAVFLGWASFGIWVFYA------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 251 nplisldlfktrtfsigivsniatrlgtgcvpflMPLMLQVGfGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGyRHT 330
Cdd:cd17476 200 ----------------------------------TQYFQNVR-GYSPLLTSARFIPMAIGGVLAAITVGFLIARLP-PSY 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 331 LV---GITVIIGLMIaqFSLQSPAMAIWMLILPLFIL---GMAMStqFTAMNTITLADLTDDNASSGNSVLAVTQQLSIS 404
Cdd:cd17476 244 IMaisMVAFLVGPIL--FATMPVHQTYWAQAFPAMIVapfGMDFS--FPAATIIASNAVPREYQGLAGSLVNTVVNYGIS 319
|
....*....
gi 693049541 405 LGVAVSAAV 413
Cdd:cd17476 320 IGLGIAGTV 328
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-177 |
5.42e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 80.39 E-value: 5.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 52 IISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRN 131
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 693049541 132 ELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIA 177
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-385 |
9.94e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.55 E-value: 9.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 17 AMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALS 96
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 97 NSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGI 176
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 177 AGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVLFSSGielfgeKIVASWIALTVIVTSIGLLLLYIlharrtpnplisl 256
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDR------RLLALFLAIFVLAFAFGALEPFL------------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 257 dlfktrtfsigivsniatrlgtgcvpflmPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITV 336
Cdd:cd17325 223 -----------------------------PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 693049541 337 IIGLMIAQFSLQSpamAIWMLILPLFILGMAMSTQFTAMNTItLADLTD 385
Cdd:cd17325 274 LSAVALLLLPLAT---SFWLLLLLLALLGLGLGLVFPATLAL-LADIVP 318
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-180 |
3.97e-17 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 82.66 E-value: 3.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 33 ALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIG 112
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 693049541 113 GAMMMPVARlALLR-AYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLInipIGIAGLL 180
Cdd:PRK11102 93 AAAASVVIN-ALMRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAIL 157
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
14-200 |
8.79e-16 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 78.96 E-value: 8.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:TIGR00710 8 LLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:TIGR00710 88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167
|
170 180
....*....|....*....|....*..
gi 693049541 174 IGIAGLLYAHKHMPNfTTARRRFDTTG 200
Cdd:TIGR00710 168 AGILLSALIFFILPE-TLPYEARIQIS 193
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-415 |
1.75e-15 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 78.82 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQsAIISYTLTVAMLIPVSGWLADRFGtRRIFTLAVSLFTL-GSLAC 93
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTW-ISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVvGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAM--MMPVARLALLRAYPRNELLPVLNFVAMPGLVgpiLGPVLGGVLV--TWATWHWIFL 169
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTqgLGAAVASELVPNKYRGLVQGVVNLVASPGSA---LGPLIAGALVeaNAAGWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 170 INIPIGIAG--LLYAHKHMPNFTTAR--------RRFDTTGFLLFGLSLVLFSSGIELFGEKIVASWIA-LTVIVTSIGL 238
Cdd:cd06179 157 INAIFNALAliLLFFFYHPPPRPQLHgsstrqklKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHvIAPLVIGGVL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 239 LLLYILHARRTP--NPLISLDLFKTRTFSIgivSNIATRLGtGCVPFLM----PLMLQVGFGYQAFIAGCMMAPTALGSI 312
Cdd:cd06179 237 LIAFGLYEWKGTkdGLLPPRLLFRGRNFAL---ILIVAFVE-GMIFYSLnifwPQQISLLFTTDPLKAGLYQLPFGLGTL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 313 IAKSMVTQVLRRLGY-RHTLVGITVIIGLMIAQFSLQSPAMAIwMLILPLFILGMAMS-TQFTAMNTITLAdLTDDNASS 390
Cdd:cd06179 313 FGAILAGLLLTKIKHiKWQLVAGFVLFTAFLALLALITPDNKA-LAIAFSVLAGIGIGgPLVLAIVIVQLS-VPPEDIGT 390
|
410 420
....*....|....*....|....*
gi 693049541 391 GNSVLAVTQQLSISLGVAVSAAVLR 415
Cdd:cd06179 391 ASGLLGSARALGGAVGTAIFTSILS 415
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
33-450 |
5.08e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.46 E-value: 5.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 33 ALPAIA-HSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGI 111
Cdd:cd17473 21 ALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 112 GGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWaTWHWIFLI---NIPIGIAGLLYAHKHMPN 188
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVyllALPVLILVLLFLPEPARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 189 FTTARRRFDTTgfllfglslvlfssgielFGEKIVASwIALTVIVTSIGLLLLYIlharrtpnplisldlfktrtfsigi 268
Cdd:cd17473 180 SKSAASPGAAT------------------AAALPWKR-VLPIYFLAFLAMLLFYV------------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 269 vsniatrlgtgcVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVgitVIIGLMIAQFSLQ 348
Cdd:cd17473 216 ------------IPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA---IGFALMALGFLLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 349 SPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLavtqQLSISLGVAVSAAVLRVYEGMEGTTTVeq 428
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV----TSAFFLGQFLSPLVLGPLVNLTGGLSG-- 354
|
410 420
....*....|....*....|..
gi 693049541 429 fhyTFITMGIITVASAAMFMLL 450
Cdd:cd17473 355 ---AFLILGVLALVLAIVLLLL 373
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
14-180 |
1.07e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 75.30 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
....*..
gi 693049541 174 IGIAGLL 180
Cdd:cd17323 162 ISGFCLI 168
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-366 |
1.23e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 75.47 E-value: 1.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSaIISYTLTVAMLIP-VSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:TIGR00895 21 LSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGF-LFSAGLIGMAFGAlFFGPLADRIGRRRVLLWSILLFSVFTLLC 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLIN-- 171
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGgi 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 172 IPIGIAGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVLFSSGIELFGEKIVASWIAltvivTSIGLLLLYILHARRTPN 251
Cdd:TIGR00895 180 APLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTK-----RSVFKALFQGKTARITVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 252 plisldLFKTRTFSIGIVSNIATRLgtgcvPFLMplmlqVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTL 331
Cdd:TIGR00895 255 ------LWLLYFMLLVGVYFLTNWL-----PKLM-----VELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA 318
|
330 340 350
....*....|....*....|....*....|....*..
gi 693049541 332 VGITVI-IGLMIAQFSLQSPAMAIWML-ILPLFILGM 366
Cdd:TIGR00895 319 LLLLLGaVFAVLVGSTLFSPTLLLLLGaIAGFFVNGG 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-188 |
2.66e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.53 E-value: 2.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170
....*....|....*
gi 693049541 174 IGIAGLLYAHKHMPN 188
Cdd:COG2223 168 LLLVVAVLAWLFLRD 182
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-414 |
5.34e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 5.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 174 IGIAGLLYAHKHMPNFTTARRRfdttgfllfglSLVLFSSGIELFGEKIVAsWIALTVIVTSIGLLLLYilharrtpnpl 253
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPG-----------SLGLLSSLLLLLRNPRLR-LAYLITFLLFGGFFALY----------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 254 isldlfktrtfsigivsniatrlgtgcvPFLMPLMLQVGFGYQAFIAGCMMApTALGSIIAKSMVTQVLRRLGYRHTLVG 333
Cdd:cd17324 219 ----------------------------TYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLIA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 334 ITVIIGLMIAqfsLQSPAMAIWMLILPLFILGMAMSTQFTAMNTItLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:cd17324 270 LLLLAAALLL---LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALGGLV 345
|
.
gi 693049541 414 L 414
Cdd:cd17324 346 L 346
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-450 |
1.10e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 72.26 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 28 TILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRI-----FTLAVSLFTLGSLACALSNSLPQL 102
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 103 VVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIpigiagllya 182
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA---------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 183 hkhmpnfttarrrfdttgfLLFGLSLVLfSSGIELFGEKIVASWIALTVIVTSIGLLLLYilharrtpnplisldlfKTR 262
Cdd:cd06173 166 -------------------LSFLLSALL-LLFIRRPPPAAPGESSSLLLRDLREGLRYLR-----------------RSP 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 263 TFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMI 342
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 343 AQFSLQSPamaIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVLRVYEGmeg 422
Cdd:cd06173 289 LVLGLSPS---LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL--- 362
|
410 420
....*....|....*....|....*...
gi 693049541 423 tttveqfHYTFITMGIITVASAAMFMLL 450
Cdd:cd06173 363 -------SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-182 |
1.72e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.45 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFM---QALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGS 90
Cdd:cd17319 3 RIIPLLFLAyviNYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 91 LACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLI 170
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170
....*....|..
gi 693049541 171 nipIGIAGLLYA 182
Cdd:cd17319 163 ---EGLLGLLLA 171
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-414 |
3.43e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.92 E-value: 3.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 16 AAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACAL 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 96 SNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTW--ATWHWIFLINIP 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 174 IGIAGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVlfssgielfgekivaswialtvivtsigllllyilharrtpnpl 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 254 isLDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVG 333
Cdd:cd06174 197 --KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 334 ITVIIglMIAQFSLQSPAMAIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:cd06174 275 IGLLL--MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
.
gi 693049541 414 L 414
Cdd:cd06174 353 L 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-241 |
1.86e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 65.31 E-value: 1.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 18 MAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSN 97
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 98 SLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIA 177
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 178 GLLYA----------HKHMPNFTTARRRFDTTGFLLFGLSLVLFSSG-------IELFGEKIVASWIALTVIVTSIGLLL 240
Cdd:cd17489 163 ALLLVflvkdpppvaAEEAEAGTRAFRRLVEKKVLPPALILFLASIAygaistfLPLYAAERGISNAGLFFTVYAIALLL 242
|
.
gi 693049541 241 L 241
Cdd:cd17489 243 S 243
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-180 |
4.40e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.16 E-value: 4.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIP--VSGWLADRFGTRRIFTLAVSLFTLGSLA 92
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGalLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 93 CALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWAT----WHWIF 168
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILF 162
|
170
....*....|..
gi 693049541 169 LINIPIGIAGLL 180
Cdd:cd17316 163 LIGALPALLALL 174
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-397 |
4.76e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.49 E-value: 4.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 6 KRSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSL 85
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 86 FTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNE--LLPVLNFVAMpglVGPILGPVLGGVLVTW-- 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAasRLNLLHAFFS---LGALLGPLLGGLLILLgl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 162 -ATWHWIFLInipigiagllyahkhmpnfttarrrfdtTGFLLFGLSLVLFSSGIELFGEKivaswialtvivtsiglll 240
Cdd:COG0738 160 sLSWHLPYLI----------------------------LAVLLLLLALLFLRSKLPEIEEE------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 241 lyilHARRTPNPLISLDLFKTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQ 320
Cdd:COG0738 193 ----EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 693049541 321 VLRRLGYRHTLVGITVIIGLMIAQFSL-QSPAMAIWMLILplfiLGMAMSTQFTAMNTITLADLTDDNASSGNSVLAV 397
Cdd:COG0738 269 LLKRFGPVRLLRLSALLAAVGLLLALLaPGPWLALIGLAL----VGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-182 |
5.23e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 63.76 E-value: 5.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 25 LDATILNTALPAIAHSLNRSPlAMQSAIISYTLtVAMLIP--VSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQL 102
Cdd:cd17365 13 FDLAVMGFVAPALAQDWGLSP-AQLGPVGSAAL-FGMAIGalLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 103 VVFRVIQGIGGAMMMPVArLALLRAYPRNELLPVLNFVAMPGL-VGPILGPVLGGVLVTWATWHWIFLINipiGIAGLLY 181
Cdd:cd17365 91 ALLRFLTGLGLGAAMPNA-ITLVSEYAPARRRSLAVTLMFCGYpLGAALGGFLAAALIPAFGWRSVFLLG---GVPPLIL 166
|
.
gi 693049541 182 A 182
Cdd:cd17365 167 L 167
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
28-195 |
6.94e-11 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 63.77 E-value: 6.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 28 TILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRV 107
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 108 IQGIG----GAMMMPVARlallRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGLLYAH 183
Cdd:PRK11652 105 IQGLGtgvgGVMARTLPR----DLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMA 180
|
170
....*....|..
gi 693049541 184 KHMPNFTTARRR 195
Cdd:PRK11652 181 RWMPETRPADAR 192
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-177 |
1.23e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSP----LAMQSAIISYTLtvamLIPVSGWLADRFGTRRIFTLAVSLFTLG 89
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDslagLLQTVFIISYMV----LSPIFGYLGDRYNRKWILAVGILIWSAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 90 SLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWA-TWHWIF 168
Cdd:cd17328 78 TLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAF 157
|
....*....
gi 693049541 169 LINIPIGIA 177
Cdd:cd17328 158 RVTGVLGVL 166
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
33-195 |
8.71e-10 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 60.34 E-value: 8.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 33 ALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIG 112
Cdd:PRK15402 35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 113 GAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGLLYAHKHMPNFTTA 192
Cdd:PRK15402 115 LCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGR 194
|
...
gi 693049541 193 RRR 195
Cdd:PRK15402 195 VGE 197
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
8-417 |
2.76e-09 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 59.30 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 8 SMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQsaiisYTLTVAMLIPVSGWLADRFGtRRIFTLAVSLFT 87
Cdd:pfam06609 45 SFAAFSLNVCATYFVLQASASALPNILQDIGQSENQGLFSTL-----WTMGQAVSILMMGRLTDRFG-RRPFVIATHIIG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 88 L-----GSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLAllraYPRNELLPVLnFVAMPGLVGPILGPVLGGVLVTWA 162
Cdd:pfam06609 119 LvgaivGCTANKFNTLLAAMTLLGVAAGPAGASPLFIGELM----SNKTKFLGLL-IVSAPTIAMNGAGPYFGQRLAIQG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 163 TWHWIFLINIPIGIAG--LLYAHKHMPNFT-----TARRR-----FDTTGFLLFGLSLVLFSSGIElFGEKIVASWIALT 230
Cdd:pfam06609 194 NWRWIFYIYIIMSAIAvlLIIIWYHPPSFAqlhgkKARKRdelakLDWIGIFLVIAGTSLFLLGVS-WGGKPNNPWNSAK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 231 VI---VTSIGLLLLYILHA--RRTPNPLISLDLFK-TRTF-SIGIVSNIATRLGTgCVPFLMPLMLQVGFGYQ------- 296
Cdd:pfam06609 273 IIgliSSGAGSLVIFALYEvfGKPEQPIIPPALFKdTRGFvCILIISSIMGAMHL-CLTIIYPQQVINIFGSSlknweet 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 297 AFIAGCMMAPTALGSIIAKSmVTQVLRRLGYRhTLVG---ITVIIGLMiAQFSLQSPAMAIWMLILPLFILGMAMSTQFT 373
Cdd:pfam06609 352 AWMSATASFGTGAGVMILGN-LFHLIRHIRWQ-ILVGalwLTAFLGAM-SSINRDNKNAAIALSFFSGFVVAWAQDITML 428
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 693049541 374 AMNTITladlTDDNASSGNSVLAVTQQLSislGVAVSAAVLRVY 417
Cdd:pfam06609 429 LVQFIT----TDEDLGVAFAVVAAARPFA---GSIFTAAFISLY 465
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-183 |
3.65e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.36 E-value: 3.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLnrspLAMQSAIISYTLTVAMLI-----PVSGWLADRFGTRRIFTLAVSLFTL 88
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAEL----GGLSPAQIGLLFGAQGLAsalsqPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 89 GSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIF 168
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*
gi 693049541 169 LINIPIGIAGLLYAH 183
Cdd:cd17325 358 LAAAALLLLAAVLFL 372
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-208 |
1.10e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.93 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPlAMQSAIISYTLTVAMLIPV-SGWLADRFGTRRIFTLAVSLFTLGSLA 92
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDE-AEAGLLGTVTLAGGAIGGIlGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 93 CALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWAT----WHWIF 168
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLF 160
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 693049541 169 LIN-IPIGIAGLLYAH-KHMPNFTTARRRFDTTGFLLFGLSL 208
Cdd:cd17371 161 LLGaLPALLVLFIRRFvKEPPQWQAARAARRHFADRPSLREL 202
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
18-182 |
3.37e-08 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 55.42 E-value: 3.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 18 MAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSN 97
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 98 SLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNE-LLPVLNFVAMPGLVGPILGPVLGGVLVTWaTWHWIFLInipIGI 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASErATAVSIFNSAQGLGGIIGGPLVGWILIHF-SWQWAFII---EGV 156
|
....*.
gi 693049541 177 AGLLYA 182
Cdd:TIGR00893 157 LGIIWG 162
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-347 |
4.00e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.89 E-value: 4.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 52 IISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAmMMPVARLALLRAYPRN 131
Cdd:cd17330 40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 132 ELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGLLYAHKHMPNFttarRRFDTTGFLLFgLSLVLF 211
Cdd:cd17330 119 ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPL----RRLLLVYFLIA-LAFAGL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 212 SSGIELF-------GEKIVASWIALTVIVTSI-GLLLLYILHARRTPNPLISLDLFKTRTFSIGIVS-------NIATRL 276
Cdd:cd17330 194 ESVFSLFlkdrfgfSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFassvpllVLAAAI 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 693049541 277 GTGCVPFLMPLML-----QVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMIAQFSL 347
Cdd:cd17330 274 LAFGTGIVFPALSallskSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
15-112 |
4.79e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 4.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACA 94
Cdd:cd17359 5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
|
90
....*....|....*...
gi 693049541 95 LSNSLPQLVVFRVIQGIG 112
Cdd:cd17359 85 FSPNFTIFIIARIIGGLA 102
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
32-168 |
7.04e-08 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 54.26 E-value: 7.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 32 TALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGI 111
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 693049541 112 GGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIF 168
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-182 |
1.07e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 53.71 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 17 AMAFFMQALDATILNTALPAIAHSLNRSpLAMQSAIIS-----YTLTVAmlipVSGWLADRFGTRRIFTLAV---SLFTL 88
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWS-KTDQGLVLSsffwgYALTQV----LGGYLADRFGGKKVLLLAValwSLATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 89 GSLACALSnSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIF 168
Cdd:cd17380 80 LTPLLAYS-SLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
|
170
....*....|....
gi 693049541 169 LInipIGIAGLLYA 182
Cdd:cd17380 159 YF---FGLLGLLWA 169
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
16-233 |
2.08e-07 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 52.91 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 16 AAMAFFMQALD----ATILNTAL--PAIAHSLN--RSPLAMQSAIISYTLTVAMLIP-VSGWLADRFGTRRIFTLAVSLF 86
Cdd:PRK15403 12 AATLFFPMALIlydfAAYLTTDLiqPGIINVVRdfNADVSLAPASVSLYLAGGMALQwLLGPLSDRIGRRPVLITGALIF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 87 TLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHW 166
Cdd:PRK15403 92 TLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKV 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 693049541 167 IFLINIPIGI---AGLLYAhkhMP-NFTTARRRFDTTGFL-----LFGLSLVLFSSGIELFGEKIVASWIALTVIV 233
Cdd:PRK15403 172 LFAIIAVMGLiafVGLLLA---MPeTVKRGAVPFSAKSVLrdfrnVFRNRLFLTGAATLSLSYIPMMSWVAVSPVI 244
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
14-368 |
2.45e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 53.16 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQS----AIISYTLTVAMLipvsGWLADRFGTRRIFTLAVSLFTLG 89
Cdd:PRK03893 23 SAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASlisaAFISRWFGGLLL----GAMGDRYGRRLAMVISIVLFSVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 90 SLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFL 169
Cdd:PRK03893 99 TLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 170 INI-PIGIAglLYAHKHMP------NFTTARRRFDTTGFLLF---------GLSLVLFSSGIELFGEKIVASW--IALTV 231
Cdd:PRK03893 179 IGIlPIIFA--LWLRKNLPeaedwkEKHAGKAPVRTMVDILYrgehriiniLLTLAAAAALWFCFAGNLQNAAivAVLGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 232 IVTSIGLLLLYILHARRTPnplisldlfktrTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGS 311
Cdd:PRK03893 257 LCAAIFISFMVQSSGKRWP------------TGVMLMVVVLFAFLYSWPIQALLPTYLKTDLGYDPHTVANVLFFSGFGA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 693049541 312 IIAKSMVTQVLRRLGYRHTLVgitviIGLMIAQFslqspamaiwmLILPLFILGMAM 368
Cdd:PRK03893 325 AVGCCVGGFLGDWLGTRKAYV-----CSLLISQL-----------LIIPVFAIGGAN 365
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
15-112 |
3.25e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 3.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLA-MQSAIISYTLTVAMLIPV-SGWLADRFGTRRIFTLAVSLFTLGSLA 92
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTsLQGLVVSSLLLGAAIGSLfGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100
....*....|....*....|
gi 693049541 93 CALSNSLPQLVVFRVIQGIG 112
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLG 100
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
22-120 |
4.51e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.89 E-value: 4.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 22 MQALDATILNTALPAIAHSLNRSPLAMQ---SAIISYTLTVAMLipvSGWLADRFGTRRIFTLAVSLFTLGSLACALSNS 98
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGwafSAGILGLLPGALL---GGRLADRIGRKRILIVSVALFGLFSLATAQAWD 102
|
90 100
....*....|....*....|....
gi 693049541 99 LPQLVVFRVIQGI--GGAMMMPVA 120
Cdd:PRK11551 103 FPSLLVARLLTGVglGGALPNLIA 126
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
15-119 |
7.87e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 51.12 E-value: 7.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLA--MQSAIISYTLTVAMLIP-VSGWLADRFGTRRIFTLAVSLFTLGSL 91
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLStgWQELIVSSTVAGAAVGAaIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110
....*....|....*....|....*....|.
gi 693049541 92 ACALSNSLPQLVVFRVIQGIG---GAMMMPV 119
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGvgiASMTVPL 111
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-178 |
9.59e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.74 E-value: 9.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 30 LNTALPAIAHS--LNRSPLAMQSAIISYTLTVAMLIpvSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRV 107
Cdd:cd17312 22 FSVAKPPIVEEigLSKDDLGIIGSAFLIAYAVGKFI--SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 693049541 108 IQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAG 178
Cdd:cd17312 100 LNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
64-160 |
1.30e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 64 PVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMP 143
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA 132
|
90
....*....|....*..
gi 693049541 144 GLVGPILGPVLGGVLVT 160
Cdd:cd17329 133 INLGVAIGPLLGGLLLL 149
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-170 |
1.45e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.35 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 13 PWIAAMAFFMQALDATILNTA---LPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLG 89
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 90 SLACALSNSLPQLVV-FRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIF 168
Cdd:cd17355 82 LVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
..
gi 693049541 169 LI 170
Cdd:cd17355 162 LV 163
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
14-229 |
1.95e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 49.95 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMM---MPVARLALLRAYPRnellPVLNFVAMPGLVGPILGPVLGGVLVTWATW-HWIFL 169
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALdvaMNAQGVAVERAYGR----PIMSSLHAMWSLGGLAGALLGAAAIGAGVSpGVHLL 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 170 INIPIGIAGLLYAHKHMP----------NFTTARRRFDTTGFLLFGLSLVLFSSgieLFGEKIVASWIAL 229
Cdd:cd17393 158 AAAVLLLLAALVAIRALLpgtgeaaedrPDGAGKPGFLLPNRLLLLLGLLALAA---ALAEGAAADWSAL 224
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-176 |
5.54e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.53 E-value: 5.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 30 LNTALPAIAHS--LNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRV 107
Cdd:TIGR00881 14 FALAMPYLVEEigLSKTDLGLLLSSFSIAYGISKF--VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWA 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 108 IQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWA-TWHWIFLINIPIGI 176
Cdd:TIGR00881 92 LNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAI 161
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-248 |
6.63e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.98 E-value: 6.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 51 AIISYTLTVAML-IPVsGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIgGAMMMPVarLALLRAYP 129
Cdd:cd17472 37 ALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVV--MALLADLT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 130 RNE-------LLPVLNFVAMpgLVGPILGPVLGGVLvtwaTWHWIFLINIPIGIAGLLYAH---KHMPNFTTAR------ 193
Cdd:cd17472 113 REEnrtkamaLIGASIGIAF--AISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLffvPDPPKIVQISekekkk 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 693049541 194 -------RRFDTTGFLLFGLSLVLFS-------SGIELFGEKIVASWIALTVIVTSIGLLLLYILHARR 248
Cdd:cd17472 187 lkkllknKRLLRLDFSIFILHFVLMAffyilplLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEK 255
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-170 |
7.55e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 47.96 E-value: 7.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 33 ALPAIAHSLNRSPlamqsAIISYTLTV-----AMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRV 107
Cdd:PRK11043 28 AFKAIQADLQTSA-----SAVSASLSLflagfALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRF 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 693049541 108 IQGIgGAMMMPVARLAL-LRAYPRNELLPVLNFVaMPgLVG--PILGPVLGGVLVTWATWHWIFLI 170
Cdd:PRK11043 103 VQAV-GVCSAAVIWQALvIDRYPAQKANRVFATI-MP-LVAlsPALAPLLGAWLLNHFGWQAIFAT 165
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-170 |
1.18e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.56 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 2 SDKKKRSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLnRSPLAMQSAIISYTLTVAMLI-----PVSGWLADRFGTR 76
Cdd:COG2807 5 SSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEI-RADLGLSATQAGLLTTLPLLAfglfaPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 77 RIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNeLLPVLNFVAMPGLVGPILGPVLGG 156
Cdd:COG2807 84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTV 162
|
170
....*....|....
gi 693049541 157 VLVTWATWHWIFLI 170
Cdd:COG2807 163 PLAAALGWRGALAV 176
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-120 |
1.50e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
90 100
....*....|....*....|....*....
gi 693049541 94 ALS--NSLPQLVVFRVIQGIGGAMMMPVA 120
Cdd:COG2211 312 FFLgpGNLWLLLVLAALAGIGLGAILVLP 340
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
15-112 |
1.74e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 46.89 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVS-----GWLADRFGTRRIFTLAVSLFTLG 89
Cdd:cd17364 3 IAGMGFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIgqlffGFLGDRFGRKRVYGVELIIMIIG 82
|
90 100
....*....|....*....|....*....
gi 693049541 90 SLACALS------NSLPQLVVFRVIQGIG 112
Cdd:cd17364 83 TILSALSpgstplGVMGWLIFFRFLLGIG 111
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
14-171 |
2.21e-05 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 46.67 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMA----FFMQALDATILNTALPAiahslnrSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLG 89
Cdd:pfam05977 16 WIASLAsnlgTLMQDVAASWLMTSLSA-------SPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 90 SLACALSN-----SLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATW 164
Cdd:pfam05977 89 STLLTLLAglgllSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGP 168
|
....*..
gi 693049541 165 HWIFLIN 171
Cdd:pfam05977 169 AFTFALN 175
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
59-180 |
2.89e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.07 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 59 VAMLIPvSGWLADRFGTRRIF---TLAVSLFTLGSLACAlSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLP 135
Cdd:cd17318 70 ILTQIP-GGYLAEKYGAKRVLgysILITALLTLLTPLAA-RGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 693049541 136 VLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLInipIGIAGLL 180
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI---FGGLGLL 189
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-181 |
5.94e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 45.32 E-value: 5.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 12 LPWIAaMAFFMQALD-ATILNTALPAIAHSLNrsplaMQSAIISYTLTVAMLI-----PVSGWLADRFGTRRIFTLAVSL 85
Cdd:cd17327 7 LPLLC-ILYFLQYLDkSNISNAAVMGMKEDLK-----LVGNQYNWGNTVFYVGyiifeLPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 86 FTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLG-GVLV----- 159
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvg 160
|
170 180
....*....|....*....|....*.
gi 693049541 160 TWATWHWIFLI----NIPIGIAGLLY 181
Cdd:cd17327 161 GLAGWRWLFIIegliTIIIGLVIFFW 186
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-183 |
8.87e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 8.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMqsAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLAC 93
Cdd:cd17489 197 LPPALILFLASIAYGAISTFLPLYAAERGISNAGL--FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 94 ALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIP 173
Cdd:cd17489 275 SFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354
|
170
....*....|
gi 693049541 174 IGIAGLLYAH 183
Cdd:cd17489 355 VVLLALVLYI 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
15-245 |
1.13e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.15 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQAldatilntalpaiAHSLNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGTRRIFTLAVSLFTLGSLACA 94
Cdd:cd17475 15 IPALAPFLQE-------------DLHLSLAQVGLLLSALNLGVAVSML--PAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 95 LSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPI 174
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 693049541 175 GIAGLLYAHKHMPNFTTARRRFDTTGFLLFGLSLVLFSSGIELFGEKIVASWIALTVIVTSIGLLLLYILH 245
Cdd:cd17475 160 SILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLG 230
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
55-120 |
1.59e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.72 E-value: 1.59e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 693049541 55 YTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVA 120
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-368 |
1.79e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 51 AIISYTLTVAMLIPVSGWLADRFG-----TRRIFTLAVSLFTLgslacALSNSLPQLVVFRVIQG-----IGGAMMMpVA 120
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGrkpmlLRASLGMAIVIGLM-----AFVTNVWQLLILRLLQGvfsgyVPNATAL-IA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 121 RLAllrayPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWatwhwiflinipIGIagllyahkhmpnfttaRRRFDTTG 200
Cdd:cd17391 115 SQT-----PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADL------------FGI----------------RNVFFITG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 201 FLLFGLSLVLFSSGIELFGEKIVASWIALTVIVTSIgllllyilharrtPNPLISLDLFKTrTFSIGIVSNIATRLGTGC 280
Cdd:cd17391 162 GLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSV-------------PNPSLLISLFVT-TFIIQLANQSIEPILTLY 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 281 VPFLMPLMLQVgfgyqAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMiaqFSLQSPAMAIWMLILP 360
Cdd:cd17391 228 IRQLMGDASNL-----AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL---YIPQAFVQTPWQLGIL 299
|
....*...
gi 693049541 361 LFILGMAM 368
Cdd:cd17391 300 RFLLGLAT 307
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-170 |
2.07e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 64 PVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPvARLALLRAY-PRNELLPVLNFVAM 142
Cdd:cd17391 258 PRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLP-AINSLLAKItPKEVAGRIFGYNQS 336
|
90 100
....*....|....*....|....*...
gi 693049541 143 PGLVGPILGPVLGGVLVTWATWHWIFLI 170
Cdd:cd17391 337 FQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
49-215 |
2.23e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.31 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 49 QSAIISYTLTVAMLI--PVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVV-FRVIQGIGGAMMMPVARLALL 125
Cdd:cd17352 39 DIAWIGSLLLGVSLFsgPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 126 RAYPRNelLPVLNFVAMPGL-VGPILGPVLGGVLVTWATWHWIFLI----NIPIGIAGLLYahkhmpnfttarRRFDTTG 200
Cdd:cd17352 119 QYFEKK--RGLATGIAVAGSgVGTFVFPPLLRYLLDNYGWRGALLIlgglCLNLCVCGLLL------------RLLKDPT 184
|
170
....*....|....*
gi 693049541 201 FLLFGLSLVLFSSGI 215
Cdd:cd17352 185 FVLLALGVSFAMLGF 199
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
190-450 |
2.38e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 190 TTARRRFDTTGFLLFGLSLVLFssgIELFGEKIVASWIALTVIVTSIGLLLLYIL--------HARRTPNPLISL--DLF 259
Cdd:COG2211 149 SSWRFAFAGLGGLLASVLPPPL---VAAFGGDAALGYRLTALIFAVLGLLAFLLTffgtkerpVPEEEKVSLKESlkALL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 260 KTRTFSIGIVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIG 339
Cdd:COG2211 226 KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 340 LMIAQFSLqSPAMAIWMLILPLFILGMAMSTQFTAMNTItLADLTD--------DNASSGNSVLAVTQQLSISLGVAVSA 411
Cdd:COG2211 306 LGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWAM-LADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAG 383
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 693049541 412 AVLRVYEGMEGTT----TVEQFHYTFITMGIITVASAAMFMLL 450
Cdd:COG2211 384 LLLALFGYVAGAAqspsALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-187 |
5.95e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.16 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 29 ILNTALPAIAHSLNRSpLAMQSAIIS-YTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRV 107
Cdd:cd17478 14 FLPALLPLLIAKLGLS-YAQAGLLVSvFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 108 IQGIGGAMMMPVA-RLALLRAYPRNELLPVLNFVAmpGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGLLYAHKHM 186
Cdd:cd17478 93 LAGIGSAAFHPEGaRLASQAAGGRRGLAMSIFSVG--GNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
.
gi 693049541 187 P 187
Cdd:cd17478 171 P 171
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
65-211 |
8.63e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 8.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 65 VSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQG--IGGAMMMPVARLALLRAYPRNELLPVLNFVAM 142
Cdd:cd17362 58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGvgIGLAMHAAPVYIAETSPSHIRGLLVSLKELFI 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 693049541 143 pgLVGPILGPVLGGVLV-TWATWHWIFLINIPIGIA---GLLYahkhMPNFTTARRRFDTTgfLLFGLSLVLF 211
Cdd:cd17362 138 --VLGILLGYVSGYAFAdVVGGWRYMYGLAAPPALLlgiGMWF----LPPSPRWQGNYRKP--LIIGLGLVLF 202
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
34-161 |
1.12e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.06 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 34 LPAIAHSLNRSPlaMQSAIISYTLTVAMLI--PVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGI 111
Cdd:cd17390 19 LSTHIRSLGASP--TVIGLIGSVYGALQLFssPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 693049541 112 GGAMMMpVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTW 161
Cdd:cd17390 97 FKHTQS-LCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAET 145
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-152 |
3.12e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 13 PWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLA 92
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 693049541 93 CALSNSLPQLVVFR---VIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGP 152
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
14-180 |
3.19e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSlnrsPLAMQSAIISYTLTVAMLIPV-SGWLADRFGTRRIFTLAVSLFTLGSLA 92
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNL----NVADVSVIFSSQNAGYLIGSLlAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 93 CALSNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRN--ELLPVLNFVAMpglVGPILGPVLGGVLVTW-ATWHWIFL 169
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESsaTRLNVLHGFFG---LGALIGPLIATSLLTSeLSWSWAYL 154
|
170
....*....|.
gi 693049541 170 INIPIGIAGLL 180
Cdd:cd17333 155 IIGLIYLLLAI 165
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
44-182 |
3.25e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.84 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 44 SPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVARLA 123
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 124 LLRAYPRN-ELLPVLNFVAMpgLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGLLYA 182
Cdd:cd17324 312 VLRLAPEArGLASSLYLAAY--NLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
29-170 |
4.08e-03 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 39.58 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 29 ILNTALPAIAHSLNRSPLamQSAIISYTLTVAMLIP--VSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQ----- 101
Cdd:PRK10489 35 LLGVAVPVQIQMMTGSTL--QVGLSVTLTGGAMFIGlmVGGVLADRYDRKKLILLARGTCGLGFIGLALNAFLPEpslla 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 102 LVVFRVIQGIGGAMMMpVARLALLRAY-PRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLI 170
Cdd:PRK10489 113 IYLLGLWDGFFGSLGV-TALLAATPALvGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVAWNYGL 181
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
15-112 |
5.46e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.18 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 15 IAAMAFFMQALDATILNTALPAIA----HSLNRSPLAMQSAIISYTLTVAMLIP-------VSGWLADRFGTRRIFTLAV 83
Cdd:pfam00083 4 VAALGGFLFGYDTGVIGAFLTLIDffknFGLSKSVSSLAALSVLSGLIVSIFSVgcfigslFAGKLGDRFGRKKSLLIAN 83
|
90 100 110
....*....|....*....|....*....|..
gi 693049541 84 SLFTLGSLACALS---NSLPQLVVFRVIQGIG 112
Cdd:pfam00083 84 VLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIG 115
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
268-452 |
5.73e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 268 IVSNIATRLGTGCVPFLMPLMLQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMIAQFSL 347
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 348 QSPamaIWMLILPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVLRVYEgmegtttve 427
Cdd:pfam07690 82 ASS---LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--------- 149
|
170 180
....*....|....*....|....*
gi 693049541 428 qFHYTFITMGIITVASAAMFMLLKT 452
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRP 173
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-183 |
7.20e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIIS-YTLTVAMLIPVSGWLADRFGTRRIFTLAVSLFTLGSLA 92
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAAlFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 93 CAL-SNSLPQLVVFRVIQGIGGAMMMPVARLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWA-TWHWIFLI 170
Cdd:COG2223 288 LALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLV 367
|
170
....*....|...
gi 693049541 171 NIPIGIAGLLYAH 183
Cdd:COG2223 368 FAVLALVALVLTL 380
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
289-451 |
8.06e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.30 E-value: 8.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 289 LQVGFGYQAFIAGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMIAQFSLqspAMAIWMLILPLFILGMAM 368
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693049541 369 STQFTAMNTItLADLTDDNASSGNSVLavtqQLSISLGVAVSAAVLRVYEGMEGTTTVeqfHYTFITMGIITVASAAMFM 448
Cdd:COG0738 111 GLLDVAANPY-VAALGPETAASRLNLL----HAFFSLGALLGPLLGGLLILLGLSLSW---HLPYLILAVLLLLLALLFL 182
|
...
gi 693049541 449 LLK 451
Cdd:COG0738 183 RSK 185
|
|
| |
