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Conserved domains on  [gi|740622742|ref|WP_038408254|]
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TetR/AcrR family transcriptional regulator [Listeria ivanovii]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
14-166 7.26e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 87.26  E-value: 7.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742  14 TRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLESTKSRE--EQLR 91
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRErlRALL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740622742  92 DMLIMLIEKHPTNILLMIHDILNEmkPENQYLLyklwqQTYLIPFQKFFQKQEATGELREGVSAEVAARYCLATI 166
Cdd:COG1309   87 RAYLEFLAENPALARLLLAEAAEL--PELRAAL-----RALLRRLRALLAELLRAGGLLADVDPDALARALLALL 154
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
14-166 7.26e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 87.26  E-value: 7.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742  14 TRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLESTKSRE--EQLR 91
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRErlRALL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740622742  92 DMLIMLIEKHPTNILLMIHDILNEmkPENQYLLyklwqQTYLIPFQKFFQKQEATGELREGVSAEVAARYCLATI 166
Cdd:COG1309   87 RAYLEFLAENPALARLLLAEAAEL--PELRAAL-----RALLRRLRALLAELLRAGGLLADVDPDALARALLALL 154
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-197 5.63e-18

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 77.63  E-value: 5.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742   7 RAEElaiTRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLESTKSR 86
Cdd:NF041196   3 RAIR---TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGGSK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742  87 EEQLRDMLIMLIEKHPTNIL------LMIHDILNEMKPENqylLYKLWQQTylipFQKFFQKQEATGELREGVSAEVAAR 160
Cdd:NF041196  80 LQELVDLTHVLARRLRTDPVvragvrLSIEQAAIGAGLPT---PYREWIDL----VAELLAEARAAGELLPGVDPEEAAR 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 740622742 161 YCLATisplFSG----KSEFAEKQTMTERIEELIDLMMFGI 197
Cdd:NF041196 153 LLVGA----FTGvqmlSDVLSGRADLPERLAELWRLLLPGI 189
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-64 8.52e-15

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 65.51  E-value: 8.52e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 740622742   18 ILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEV 64
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 4-95 3.34e-07

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 48.97  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742   4 KRTRAEELAiTRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEV------VRELTQQ---IQI 74
Cdd:PRK09975   3 KKTKAEALK-TRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMwlqqppLRELIQEhltAGL 81

                         90       100
                 ....*....|....*....|.
gi 740622742  75 EMQPLlestksreEQLRDMLI 95
Cdd:PRK09975  82 EHDPL--------QQLREKFI 94
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-67 7.42e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 7.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 740622742  14 TRRKILDtasdLFMEKGYravSTREIANRVNITQPALYHHFED-KEALYIEVVRE 67
Cdd:cd00090    8 TRLRILR----LLLEGPL---TVSELAERLGLSQSTVSRHLKKlEEAGLVESRRE 55
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
14-166 7.26e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 87.26  E-value: 7.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742  14 TRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLESTKSRE--EQLR 91
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRErlRALL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740622742  92 DMLIMLIEKHPTNILLMIHDILNEmkPENQYLLyklwqQTYLIPFQKFFQKQEATGELREGVSAEVAARYCLATI 166
Cdd:COG1309   87 RAYLEFLAENPALARLLLAEAAEL--PELRAAL-----RALLRRLRALLAELLRAGGLLADVDPDALARALLALL 154
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-197 5.63e-18

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 77.63  E-value: 5.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742   7 RAEElaiTRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLESTKSR 86
Cdd:NF041196   3 RAIR---TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGGSK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742  87 EEQLRDMLIMLIEKHPTNIL------LMIHDILNEMKPENqylLYKLWQQTylipFQKFFQKQEATGELREGVSAEVAAR 160
Cdd:NF041196  80 LQELVDLTHVLARRLRTDPVvragvrLSIEQAAIGAGLPT---PYREWIDL----VAELLAEARAAGELLPGVDPEEAAR 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 740622742 161 YCLATisplFSG----KSEFAEKQTMTERIEELIDLMMFGI 197
Cdd:NF041196 153 LLVGA----FTGvqmlSDVLSGRADLPERLAELWRLLLPGI 189
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-64 8.52e-15

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 65.51  E-value: 8.52e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 740622742   18 ILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEV 64
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
4-109 5.31e-11

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 59.18  E-value: 5.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742   4 KRTRAEElaiTRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLEST 83
Cdd:COG3226    2 RRRRGEE---RRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAA 78

                         90       100
                 ....*....|....*....|....*....
gi 740622742  84 KSRE---EQLRDMLIMLIEKHPTNILLMI 109
Cdd:COG3226   79 DDLEdaaEALADLLAELLPADRDRLLARY 107
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 4-95 3.34e-07

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 48.97  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742   4 KRTRAEELAiTRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEV------VRELTQQ---IQI 74
Cdd:PRK09975   3 KKTKAEALK-TRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMwlqqppLRELIQEhltAGL 81

                         90       100
                 ....*....|....*....|.
gi 740622742  75 EMQPLlestksreEQLRDMLI 95
Cdd:PRK09975  82 EHDPL--------QQLREKFI 94
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 4-116 5.65e-06

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 45.43  E-value: 5.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740622742   4 KRTRAEElaiTRRKILDTASDLFMEKGYRAvSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPLLEST 83
Cdd:PRK11552   7 MTTRGEQ---AKQQLIAAALAQFGEYGLHA-TTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEEA 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 740622742  84 ksreeqlrDMLIMLIEKHPTNILLMIHDILNEM 116
Cdd:PRK11552  83 --------ERLFAQPAPDRAAIRELILRACLNM 107
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 3-64 1.02e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 44.61  E-value: 1.02e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740622742   3 KKRTRAEElaiTRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEV 64
Cdd:PRK10668   4 KTKQQAQE---TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 4-79 1.24e-04

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 41.45  E-value: 1.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740622742   4 KRTRAeeLAITRRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVReltQQIQIEMQPL 79
Cdd:PRK15008  11 KRSRA--VSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLR---QILDIWLAPL 81
PRK13756 PRK13756
TetR family transcriptional regulator;
15-79 2.73e-04

TetR family transcriptional regulator;


Pssm-ID: 172294 [Multi-domain]  Cd Length: 205  Bit Score: 40.26  E-value: 2.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740622742  15 RRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQIEMQPL 79
Cdd:PRK13756   6 KEKVIDSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEILDRHHTHFLPL 70
PRK11640 PRK11640
putative transcriptional regulator; Provisional
 15-90 7.34e-04

putative transcriptional regulator; Provisional


Pssm-ID: 183252 [Multi-domain]  Cd Length: 191  Bit Score: 38.82  E-value: 7.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740622742  15 RRKILDTASDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRELTQQIQI-EMQPLLESTKSREEQL 90
Cdd:PRK11640   3 REDVLGEALKLLEQQGLANTTLEMLAERVDYPLDELQRFWPDREALLYDALRYHSQQIDTwRRQLLLDETLSAEQKL 79
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-67 7.42e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 7.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 740622742  14 TRRKILDtasdLFMEKGYravSTREIANRVNITQPALYHHFED-KEALYIEVVRE 67
Cdd:cd00090    8 TRLRILR----LLLEGPL---TVSELAERLGLSQSTVSRHLKKlEEAGLVESRRE 55
PRK11202 PRK11202
HTH-type transcriptional repressor FabR;
6-67 8.95e-04

HTH-type transcriptional repressor FabR;


Pssm-ID: 236881 [Multi-domain]  Cd Length: 203  Bit Score: 38.83  E-value: 8.95e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740622742   6 TRAEELAITRRKILDTA-SDLFMEKGYRAVSTREIANRVNITQPALYHHFEDKEALYIEVVRE 67
Cdd:PRK11202   4 VRAQQKEKTRRALIDAAfSQLSAERSFSSLSLREVAREAGIAPTSFYRHFRDMDELGLTMVDE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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