|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
39-428 |
7.32e-38 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 140.81 E-value: 7.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 39 VSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIM 118
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 119 AAiinSIFLLFISLLIYGAGTATNLQARYA-GTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvpSLAG 197
Cdd:cd17489 81 AT---SVALLLVLRLIHGIGWGAFTTAAATlVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL------GFAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 198 PFILAAAAYMLAgvVLFIMLRPDPLVIArtieAANEEPGDKGHLAATEhtenkKGIIVGATVMVLTQIVMVAIMTMTPVH 277
Cdd:cd17489 152 LFIVAAVLALLA--LLLVFLVKDPPPVA----AEEAEAGTRAFRRLVE-----KKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 278 MRHHGHDlgAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGttLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNF 357
Cdd:cd17489 221 AAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGL--LLLALGLLLLSFAGSPWMLLLAAVLYGLGFGL 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740642681 358 GLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFR 428
Cdd:cd17489 297 LFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
59-428 |
6.22e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.05 E-value: 6.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 59 LIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTglsagFMIGGLGAIGV--IMAAIINSIFLLFISLLIYG 136
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR-----LLLLGLLLLAVstLLFAFATSYWQLLLARFLQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 137 AGTATNLQARYA-GTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvpSLAGPFILAAAAYMLAGVVLFI 215
Cdd:cd17325 96 LASAAVWPAAMAlIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL------GYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 216 MLRPDPLVIARTIEAANEEPGDKGHLAatehteNKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGH-DLGAVGLVIGF 294
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLL------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 295 HIGAMYLPSLVTGVLVDRLGRTAMAISSgtTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTAT 374
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIG--LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 740642681 375 RAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFR 428
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-392 |
1.62e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.18 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 33 KRTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLG 112
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 113 AIGvimAAIINSIFLLFISLLIYGAGTATNLQARYA-GTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsig 191
Cdd:COG2814 89 SLL---CALAPSLWLLLAARFLQGLGAGALFPAALAlIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 192 vpSLAGPFILAAAAYMLAGVVLFIMLRPDPlviartieaaneEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIM 271
Cdd:COG2814 162 --GWRWVFLVNAVLALLALLLLLRLLPESR------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 272 TMTPVHMRH-HGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAIssGTTLLLAGVIAAFAPGDSMVLLVIALSL 350
Cdd:COG2814 228 TYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWLLLLALFL 305
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 740642681 351 LGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA 392
Cdd:COG2814 306 LGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
44-393 |
2.56e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.77 E-value: 2.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 44 IFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFmigGLGAIGVIMAAIIN 123
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGL---LLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 124 SIFLLFISLLIYGAGTATNLQARYAG-TDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvpSLAGPFILA 202
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALiADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------GWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 203 AAAYMLAGVVLFIMLRPDPLVIARTIEAANEEPGDKGHLAAtehtenKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHG 282
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL------RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 283 HDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLG-RTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLIS 361
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|..
gi 740642681 362 GTALIVDSTDTATRAKTQGTVDVLIALSGAAG 393
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-430 |
4.90e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.98 E-value: 4.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 34 RTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGA 113
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 114 igvIMAAIINSIFLLFISLLIYGAGTATNLQARYAG-TDLANHKQRATAVSITMVFTTFGAVAGPSLVnvmgdfALSIGV 192
Cdd:COG2271 90 ---LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLiAEWFPPKERGRALGIFNAGGPLGGALAPPLL------GWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 193 PSLAGPFILAAAAYMLAGVVLFIMLrpdplviartieaaneepgdkghlaatehtenkkgiivgATVMVLTQIVMVAIMT 272
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL---------------------------------------ALAYFLVYFALYGFLT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 273 MTPVHMR-HHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLL 351
Cdd:COG2271 202 WLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740642681 352 GLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFRGR 430
Cdd:COG2271 282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-428 |
6.39e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.87 E-value: 6.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 41 ISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAA 120
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 121 IIN--SIFLLFISLLIYGAGTATNLQARYA-GTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMgdfalsIGVPSLAG 197
Cdd:cd06173 86 LLGslSLWLLLVLAFLLGIASAFFGPARQAlLPELVPKEQLVRANALNSLATQLARIIGPALGGLL------VALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 198 PFILAAAAYMLAGVVLFIMLRPDPLViartiEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVH 277
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAA-----PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 278 MRHHGH-DLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPgdSMVLLVIALSLLGLGWN 356
Cdd:cd06173 235 AKEVLGgGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP--SLWLLLAALFLLGLAGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740642681 357 FGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSyLALSFAGGMLSLLLIPVVVWFR 428
Cdd:cd06173 313 LFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
88-427 |
9.44e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.46 E-value: 9.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 88 IVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAI--------INSIFLLFISLLIYGAGTATNLQARYA-GTDLA-NHKQ 157
Cdd:COG2211 65 LIGALSDRTRTRWGRRRPWILIGAIPLALSFVLLftapdlspTGKLIYALVTYLLLGLAYTLVNIPYSAlGAELTpDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 158 RATAVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLRpdplviaRTIEAANEEPGD 237
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK-------ERPVPEEEKVSL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 238 KGHLAATehTENKKGIIVgATVMVLTQIVMVAIMTMTPVHMRHH-GHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRT 316
Cdd:COG2211 218 KESLKAL--LKNRPFLLL-LLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKK 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 317 AMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTD-------TATRAKTQGTVDVLIALS 389
Cdd:COG2211 295 KAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLG 374
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 740642681 390 GAAGGALSGMIVAGSSYLA------LSFAGGMLSLLLIPVVVWF 427
Cdd:COG2211 375 QALAGALAGLLLALFGYVAgaaqspSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
60-428 |
6.56e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.40 E-value: 6.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 60 IAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGfmiGGLGAIGVIMAAIINSIFLLFISLLIYGAGT 139
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAG---LLLRALGFALLGFAHSPWLFAIALVLTGFGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 140 ATNLQARYAG-TDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFALSIgvpslagPFILAAAAYMLAGVVLFIMLR 218
Cdd:cd17329 103 GLFEPASEAMiADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL-------LFLAAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 219 PDplviaRTIEAANEEPGDKGHLAATEHTENKKGIIVGatvMVLTQIVMVAIMTMTPVHMRHHGHD-LGAVGLVIGFHIG 297
Cdd:cd17329 176 ET-----RPKRRAAEKTEILRGYKIVLRDRAFLLFLLA---SFLISLIYFQLESTLPVYVVEILGLgESLLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 298 AMYLPSLVTGVLVDRLGRTaMAISSGTTLLLAGVIAAFAPGdSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAK 377
Cdd:cd17329 248 LIVLLQFPVARLVERFRLR-KILMIGILLFAIGFAVLAFAN-TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGS 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 740642681 378 TQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFR 428
Cdd:cd17329 326 YMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
60-424 |
8.93e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 8.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 60 IAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAIINsIFLLFISLLIYGAGT 139
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA-LLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 140 ATNLQARYAGtDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFalsigvpSLAGPFILAAAAYMLAGVVLFIMLRP 219
Cdd:cd17474 104 LGPLALTLIG-DLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-------SWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 220 DPlviartieaANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGH-DLGAVGLVIGFHIGA 298
Cdd:cd17474 176 PK---------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGiSPIIIGLLFAGWSVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 299 MYLPSLVTGVLVDR--LGRTAMAISsgtTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRA 376
Cdd:cd17474 247 LALGSLFVGRLLKKrfGARRILVIG---LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 740642681 377 KTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVV 424
Cdd:cd17474 324 TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
59-353 |
2.27e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.80 E-value: 2.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 59 LIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMiggLGAIGVIMAAIINSIFLLFISLLIYGAG 138
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPL---LTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 139 TATNLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVnvmgdfALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR 218
Cdd:cd17478 98 SAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIA------AALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 219 PDPLVIARTieaaneepgDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGA 298
Cdd:cd17478 172 LKKPEAKKA---------AAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFA 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 740642681 299 MYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGdsmVLLVIALSLLGL 353
Cdd:cd17478 243 GAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG---IWSYILLVLAGF 294
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-421 |
2.97e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.41 E-value: 2.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 36 LFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFmigGLGAIG 115
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLL---LLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 116 VIMAAIINSIFLLFISLLIYG--AGTATNLQARYAGtDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvp 193
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGlaHGGFWAIAAAYAA-DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 194 SLAGPFILAAAAYMLAGVVLFIMLRPDPlviartieaaNEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMT- 272
Cdd:cd17324 151 GWRAAFLAIAVLALLAALLLWRLLPSLP----------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTy 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 273 MTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPgdSMVLLVIALSLLG 352
Cdd:cd17324 221 LAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP--SPLLLLVGLVLWG 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740642681 353 LGWNFGLISGTALIVDSTDTAtRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLI 421
Cdd:cd17324 299 LGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
67-354 |
3.96e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.02 E-value: 3.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 67 TDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAiinSIFLLFISLLIYGAGTATNLQAR 146
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP---SYPLLLLALFLLGLGLGLLDVAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 147 YAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFALSIGVpslAGPFILAAAAYMLAGVVLFIMLRPdplviar 226
Cdd:COG0738 118 NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSW---HLPYLILAVLLLLLALLFLRSKLP------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 227 tiEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMR-HHGHDLGAVGLVIGFHIGAMYLPSLV 305
Cdd:COG0738 188 --EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFL 265
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 740642681 306 TGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGdsMVLLVIALSLLGLG 354
Cdd:COG0738 266 GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG--PWLALIGLALVGLG 312
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
60-420 |
6.14e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.52 E-value: 6.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 60 IAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAigVIMAAIINSIFLLFISLLIYGAGT 139
Cdd:cd06174 22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA--LLFAFAPSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 140 ATNLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPslvnVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLRP 219
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGP----LLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 220 DPlvIARTIEAANEEPGDKGHLAATEHteNKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAM 299
Cdd:cd06174 176 PP--ESARAKNEEASSKSVLKLLKRVL--KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 300 YLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQ 379
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 740642681 380 GTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLL 420
Cdd:cd06174 332 GLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLL 372
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
44-420 |
8.68e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.88 E-value: 8.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 44 IFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGfmiGGLGAIGVIMAAIIN 123
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAG---AAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 124 SIFLLFISLLIYGAGTAtnlqARYAGTD-----LANHKQRATAVSITMVFTTFGAVAGPSLVNVMGdfalsigvPSLAGP 198
Cdd:cd17477 83 SPWVWFLLRFVMGIGLA----GLFVVSEswlnaLATNENRGRVLGLYSTVLGLGFALGPLLLALVG--------TAGALP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 199 FILAAAAYMLAGVVLFIMLRPDPlviartieaaNEEPGDKGHLAATehtenKKGIIVGATVMVLTQIVMVAIMTMTPVHM 278
Cdd:cd17477 151 FLIAAVLLLLALVPLLLTRRAAP----------EIEEAESISLRRL-----LRIAPLALLGAFVAGFLEGAFYSLLPLYG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 279 RHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGwnFG 358
Cdd:cd17477 216 LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAA--GP 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740642681 359 LIS-GTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSG--MIVAGSSYLALSFAGGMLSLLL 420
Cdd:cd17477 294 LYTlALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGalMDAFGPHGLFLFLAAVALLFLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
34-430 |
3.47e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.35 E-value: 3.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 34 RTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTglsAGFMIGGLGA 113
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 114 IGVIMAAIINSIFLLFISLLIYGAGTATNLQaryAGTDLAN----HKQRATAVSITMVFTTFGAVAGPSLVNVMgdfals 189
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFA---VGIALVSkwfpPDRRGLALGLAAGGGNLGAAVAAFLAPLL------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 190 IGVPSLAGPFILAAAAYMLAGVVLFIMLRPDPlviARTIEAANEEPGDKGHLAATEHTenkkgiIVGATVMVLTQIVMVA 269
Cdd:COG2223 153 IAAFGWRNAFLILGILLLVVAVLAWLFLRDPP---AGAAAAAKASLRDQLEALRDPRF------WLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 270 IMTMTPVHMR-HHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGdSMVLLVIAL 348
Cdd:COG2223 224 FSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLVLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 349 SLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFR 428
Cdd:COG2223 303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
..
gi 740642681 429 GR 430
Cdd:COG2223 383 YR 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-429 |
1.02e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 53.73 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 48 AGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAigvIMAAIINSIFL 127
Cdd:cd17473 14 AGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG---VAGLFLDSLYA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 128 LFISLLIYGAGTA------TNLQAryagtDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFalsigvpSLAGPFIL 201
Cdd:cd17473 91 LLASRALLGIGVAgimtlaTALIG-----DYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-------GWRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 202 aaaaYMLAGVVLfimlrpdPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHH 281
Cdd:cd17473 159 ----YLLALPVL-------ILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 282 G-HDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLI 360
Cdd:cd17473 228 GgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740642681 361 SgtALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFRG 429
Cdd:cd17473 308 N--SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
243-427 |
2.58e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 243 ATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISS 322
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 323 GTTLLLAGVIAAFAPgdSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVA 402
Cdd:COG2814 82 LLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*
gi 740642681 403 GSSYLALSFAGGMLSLLLIPVVVWF 427
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
253-428 |
3.25e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 3.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 253 IIVGATVMVLTQIVMVAIMTMTPVHMRHHGHD-LGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSgtTLLLAGV 331
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLsASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAG--LLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 332 IAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSF 411
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA 158
|
170
....*....|....*..
gi 740642681 412 AGGMLSLLLIPVVVWFR 428
Cdd:cd17329 159 AAVLFLLAALVLLFLLP 175
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-428 |
4.78e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.50 E-value: 4.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 36 LFVVSISQIFG-GAGLAAGVTVGALIAQQMLGTDAFAgLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMiggLGAI 114
Cdd:cd17355 5 LAVTFLILILSwGIRYYFGVFIIPIIAEFGWSRAVIS-LAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLL---LLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 115 GVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANH--KQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigv 192
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWfeRRRGLALGILTAGGGLGSLVFLPLGAALIEAF----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 193 pSLAGPFILAAAAYMLAGVVLFIMLRPDPlviARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMT 272
Cdd:cd17355 156 -GWRTALLVLALLALLVLVPVLLLLRRRP---ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 273 MTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALsLLG 352
Cdd:cd17355 232 HLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAA-LFG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740642681 353 LGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVWFR 428
Cdd:cd17355 311 LGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
199-424 |
6.42e-07 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 51.07 E-value: 6.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 199 FILAAAAYMLAGVVLFIMLRPDPLVIARTIEAANEEPGDKGHLAATehtenkKGIIVGATVMVLTQIVMVAIMTMTPVHM 278
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRR------PGTRWLLLFLLLYKLGEQGALAMLPPFL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 279 RHHGHDLGAVGLVIG-FHIGAMYLPSLVTGVLVDRLG-RTAMAISSGTTLLLAGVIAAFA---PGDSMVLLVIALSLLGL 353
Cdd:cd17485 235 VDRGFSLSQIGLLSGvGGSLVSIAGSLLGGYLLKRRGrRRLLLLGGLLRLLLLGLYTLLAlggSGLNWVLLLASLALLHL 314
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740642681 354 GWNFGLISGTALIVDSTD---TATRAKTQGTVDVLIALsgaAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVV 424
Cdd:cd17485 315 VGGMITTALFTLMMDCSQqaqAGTDYTLLATVEVLGKL---LFGSLAGFLADHLGYAAAFLLFAILSALSVLLL 385
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-430 |
1.44e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 23 SSPEKQKSLYKRTLFVVSIsqIFGGAGLAAGVT----VGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGR 98
Cdd:COG2807 5 SSSARRSRRAGRWLLLLAI--VLVALNLRPAITsvgpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 99 RTGLSAGfmiGGLGAIGVIMAAIINSIFLLFISLLIYGAGTA--TNLQARYAGTDLANHkqRATAVSITMVFTTFGAVAG 176
Cdd:COG2807 83 ERTLLLA---LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAvgNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAALA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 177 PSLVnvmgdfalsigvPSLAGPFILAAAAYMLAGVVLFIMLrpdpLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVG 256
Cdd:COG2807 158 AGLT------------VPLAAALGWRGALAVWALLALLALL----LWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 257 AtVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIA-AF 335
Cdd:COG2807 222 L-FFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGlLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 336 APGDSMVLLVIalsLLGLGWNFGLISGTALIVDST-DTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGG 414
Cdd:COG2807 301 APGSLPWLWAV---LLGLGQGGLFPLALTLIGLRArTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLL 377
|
410
....*....|....*.
gi 740642681 415 MLSLLLIPVVVWFRGR 430
Cdd:COG2807 378 AALAVLMLVAGLLAGR 393
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
90-420 |
6.23e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.98 E-value: 6.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 90 GRLSQRYGRRTGLSAGFMIGglgAIGVIMAAIINSIFLLFISLLIYGAGT-ATNLQARYAGTDLANHKQRATA---VSIT 165
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLF---IAGSLLAAYATSIYGLILGRALQGSGAiSSVVMALLADLTREENRTKAMAligASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 166 MVFtTFGAVAGPSLVNVmgdfalsIGVPSLagpFILAAAAYMLAGVVLFIMLRPDPLVIArtiEAANEEPGDKGHLAate 245
Cdd:cd17472 130 IAF-AISMVLGPLLAAH-------LGVSGL---FLITAILSLVSLLILLFFVPDPPKIVQ---ISEKEKKKLKKLLK--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 246 hteNKKGIIVGATVMVLtQIVMVAIMTMTPVHMRHHGHDLGAVGLVigfhigamYLPSLVTGVLV--------DRLGRTA 317
Cdd:cd17472 193 ---NKRLLRLDFSIFIL-HFVLMAFFYILPLLLTQLGGGKGQLWKV--------YLPAILIGFILmvpfviyaEKKGKMK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 318 MAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALS 397
Cdd:cd17472 261 QVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALG 340
|
330 340
....*....|....*....|...
gi 740642681 398 GMIVAGSSYLALSFAGGMLSLLL 420
Cdd:cd17472 341 GLLWGLLGYSSVFLTILILALLW 363
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-425 |
7.05e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 7.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 47 GAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAaiiNSIF 126
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT---PSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 127 LLFISLLIYGAGTATNLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPslagpfILAAAAY 206
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWA------YLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 207 MLAGVVLFIMLRPDPLViartiEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGH-DL 285
Cdd:cd17333 160 YLLLAILILLTLFPELP-----SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHvSD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 286 GAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPgdSMVLLVIALSLLGLGwnFGLISGTAL 365
Cdd:cd17333 235 GLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAP--TLVVGLVATALLGLF--MAALFPTIL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740642681 366 IVDStDTATRAKTQGTVDVLIA--LSGAAGGALSGMIV-AGSSYLALSFAGGMLSLLLIPVVV 425
Cdd:cd17333 311 SLGI-SNLPYAKGKGTSVLLAAgsIGGAIIPFIMGFIAeAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
66-179 |
4.21e-05 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 45.28 E-value: 4.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 66 GTDAFAGLPSALFTLGSAGSALIVGRLSQRYG-RRTGLSAGFMIGGLGAIGVIMAAII--NSIFLLFISLLIYGAGTATN 142
Cdd:cd17326 33 ATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFpsNRKYVMLVARFLIGVGAGNV 112
|
90 100 110
....*....|....*....|....*....|....*..
gi 740642681 143 LQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPSL 179
Cdd:cd17326 113 AVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPAL 149
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
60-427 |
4.27e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.26 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 60 IAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAaiiNSIFLLFISLLIYGAGT 139
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA---SSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 140 ATnlqaryagtdlanhkqrATAVSITMVFTTFGAVAGPS-LVNVMGDFALSIGVPSLAGPFILAAAAY-------MLAGV 211
Cdd:cd17320 102 AA-----------------GSVVARAIVRDLYSGAELAKiFSLLMMILAIAPALAPLLGGLLLLFFGWraifvflALLGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 212 VLFIMLRpdpLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTP-VHMRHHGHDLGAVGL 290
Cdd:cd17320 165 LLLLLVL---LFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPfIYIEQLGLSPAQFGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 291 VIGFHIGAMYLPSLVTGVLVDRLG-----RTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTAL 365
Cdd:cd17320 242 LFALNAIALILGSLLNGRLVRRFGprrllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740642681 366 IVDSTDTATRAKTQGTVDVLIalsGAAGGALSGMIVAGSsylALSFAGGMLSLLLIPVVVWF 427
Cdd:cd17320 322 EPFPHVAGTASALLGFLQFLI---GALAGALVGLLPNGT---ALPMGLLILVLGLLALLLLI 377
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
88-413 |
5.20e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.29 E-value: 5.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 88 IVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLA----------NHKQ 157
Cdd:cd17332 54 LMGYLIDRTRSRWGRFRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPytalipeltdDPEE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 158 RATAVSITMVFTTFGAVAGPSLVnvmGDFALSIGVPSLAGPFILAAAAYMLAGVVLFImlrpdpLVIARTIEAANEEPGD 237
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLP---PPLVAYFGGGNASRGYFLTALIIGIIGIILLL------ICFFGTRERVVPPEEE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 238 KGHLAATEHTE----NKKGIIVGAtVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRL 313
Cdd:cd17332 205 KSKLPLLKSLKallkNRPFLILLL-AYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRF 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 314 GRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTD---TATRAKTQGTVDVLIALSG 390
Cdd:cd17332 284 GKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDygeLKTGKRREGIFYSVMTFFR 363
|
330 340
....*....|....*....|...
gi 740642681 391 AAGGALSGMIVAgssyLALSFAG 413
Cdd:cd17332 364 KLGLALAGALVG----LILSLAG 382
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
37-219 |
7.10e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.92 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 37 FVVSISQIFG-GAGLAAGVTVGALIAQqmLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTglsagFMIGG--LGA 113
Cdd:cd06179 1 AALCLAYFAQlFGVTLPAAVLPFIVAD--LGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRW-----FFIGGnlLGV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 114 IGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMgdfaLSIGVP 193
Cdd:cd06179 74 VGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGAL----VEANAA 149
|
170 180
....*....|....*....|....*.
gi 740642681 194 SLAGPFILAAAAYMLAGVVLFIMLRP 219
Cdd:cd06179 150 GWRWIFYINAIFNALALILLFFFYHP 175
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
63-140 |
8.95e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 44.66 E-value: 8.95e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740642681 63 QMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAIINSIfLLFISLLIYGAGTA 140
Cdd:pfam06609 72 QDIGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTL-LAAMTLLGVAAGPA 148
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-214 |
1.30e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 31 LYKRTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGG 110
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 111 LGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVnvmgdFALSI 190
Cdd:cd17316 255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI-----ALLLA 329
|
170 180
....*....|....*....|....
gi 740642681 191 GVPSLAGPFILAAAAYMLAGVVLF 214
Cdd:cd17316 330 STGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-428 |
2.31e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 267 MVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPgdSMVLLVI 346
Cdd:pfam07690 13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 347 ALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVW 426
Cdd:pfam07690 91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
|
..
gi 740642681 427 FR 428
Cdd:pfam07690 171 PR 172
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
67-416 |
2.90e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.56 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 67 TDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLsaGFMIGGLGAIGVIMAAIINSIFLLFISLLIyGAGTATNLQAR 146
Cdd:cd17319 36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVL--AVSMLLWSLFTALTGFATSLTSLYVLRFLL-GVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 147 -YAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMgdfalsIGVPSLAGPFILAAAAYMLAGVVLFIMLRpdplvia 225
Cdd:cd17319 113 iKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFGWRWAFIIEGLLGLLLAVLWWFYLR------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 226 rtieaaneepgdkghlaatehtenkkGIIVGATVMVLTQIVMVAIMTMTPVHMRH-HGHDLGAVGLVIGFHIGAMYLPSL 304
Cdd:cd17319 180 --------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 305 VTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAP-GDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVD 383
Cdd:cd17319 234 LGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYlTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLIN 313
|
330 340 350
....*....|....*....|....*....|....*
gi 740642681 384 VLIALSGAAGGALSGMIVA--GSSYLALSFAGGML 416
Cdd:cd17319 314 SGGNLGGFVAPLLIGYLVDatGSYTAAFLFLAAVA 348
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
68-352 |
3.02e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 68 DAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSagFMIGGLGAIGVIMAAIIN-SIFLLFisLLIYGAGTATN-LQA 145
Cdd:TIGR00898 126 AWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLL--LSTLVTAVSGVLTAFSPNyTVFLVF--RLLVGMGIGGIwVQA 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 146 RYAGTDLANHKQRATAVSITMVFTTFGAVAGPSL-VNVMGDFALSIGVpslAGPFILAAAAYmlagvvLFIMLRPDPLVI 224
Cdd:TIGR00898 202 VVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVaYFIPDWRWLQLAV---SLPTFLFFLLS------WFVPESPRWLIS 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 225 ARTIEAANE------------EPGDKGHLAATEHTENKKGIivgATVMVL---------TQIVMVAIMTMTPVH--MRHH 281
Cdd:TIGR00898 273 QGRIEEALKilqriakingkkLPAEVLSLSLEKDLSSSKKQ---YSFLDLfrtpnlrktTLCLMMLWFTTAFSYygLVLD 349
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740642681 282 GHDLGAVGLVIGFHIGAMYLPS-LVTGVLVDRLGR-TAMAISsgttLLLAGV---IAAFAPGDsMVLLVIALSLLG 352
Cdd:TIGR00898 350 LGNLGGNIYLDLFISGLVELPAkLITLLLIDRLGRrYTMAAS----LLLAGVallLLLFVPVD-LYFLRTALAVLG 420
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
58-214 |
3.62e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 58 ALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGA 137
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMG 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740642681 138 GTATNLQARYAgtDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvpSLAGPFILAAAAYMLAGVVLF 214
Cdd:cd17370 303 AQESIERAAVA--DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI------SPSAAFLFSAVLALIALLLLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
44-221 |
4.12e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.18 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 44 IFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAIIN 123
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 124 SIFLLFISLLIYGAGTATNLQARYAGtDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFALSIgvpslAGPFILAA 203
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY-----TAAFLVFA 369
|
170
....*....|....*...
gi 740642681 204 AAYMLAGVVLFIMLRPDP 221
Cdd:COG2223 370 VLALVALVLTLLLYRRPR 387
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
51-356 |
5.25e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.84 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 51 AAGVTVGALIAQQMLGTDAF--AGLPSALFtLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGvimAAIINSIFLL 128
Cdd:cd17475 12 AQGIPALAPFLQEDLHLSLAqvGLLLSALN-LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL---MALVGSYPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 129 FISLLIYGAGTATnlqARYAGTDLANH----KQRATAVSITMVFTTFGAVAGPSLVNVMgdfALSIGVPSLagpFILAAA 204
Cdd:cd17475 88 LVLLFLVGAGYGS---VQPGGGRAIMRwfppRERGLAMGIRQTGVPLGGALAAALLPPL---ALHYGWRAA---FVVAGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 205 AYMLAGVVLFIMLRPDPLVIARTIEAANEEPGDKGHLaateHTENKKGIIVGATVMVLTQIVMVAIMtMTPVHmRHHGHD 284
Cdd:cd17475 159 VSILAAVLFWLFYREPPAASAATESASTLLRSLKEVL----RNRDVWLIAIAGALLVAPQFALLTFL-LLFLH-DHLGLS 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740642681 285 LGAVGLVIGFHIGAMYLPSLVTGVLVDRLG----RTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGL---GWN 356
Cdd:cd17475 233 VVAAGALLAVAQLGGALGRIGLGRVSDRVFggrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLfaiGWN 311
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
72-172 |
5.96e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.85 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 72 GLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIgvIMAAIINSIFLLFISLLIYG--AGTATNLQARYAg 149
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAI--IQVAAIGKWYQLIVGRIIAGlgVGFASVLVPVYQ- 124
|
90 100
....*....|....*....|...
gi 740642681 150 TDLANHKQRATAVSITMVFTTFG 172
Cdd:cd17356 125 SEVAPKHIRGTLVSLYQLAITIG 147
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-177 |
6.92e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 6.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 1 MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTL 80
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 81 GSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYA-GTDLANHKQRA 159
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAlVSDLAPKEERG 326
|
170
....*....|....*...
gi 740642681 160 TAVSITMVFTTFGAVAGP 177
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
70-224 |
8.17e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 8.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 70 FAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMiggLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAG 149
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLA---GSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYI 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740642681 150 TDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvpSLAGPFILAAAAYMLAGVVLFIMLRPDPLVI 224
Cdd:cd17330 112 ADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY------GYALPFLVAAALALLNLVLVLFFLPPLRRLL 180
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
64-425 |
8.65e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 8.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 64 MLGTDAFA-GLPSALFTLGSAGSALIVGRLSQRYGRRTGL-SAGFmigGLGAIGVIMAAIINSIFLLFISLLIYGAGTAT 141
Cdd:cd17370 28 VLGASAAAvGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGY---GLSALAKPLLALAGSWQLVLLLRILERLGKGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 142 NLQARYAG-TDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMgdfaLSIGVPSLAGPFILAAAAYMLAGVVLFImlrpd 220
Cdd:cd17370 105 RTPPRDALlADATPPSGRGKAFGLHRALDTLGAVLGPLLAALL----LYLLGGNYRTIFLLAAIPALLALLILLF----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 221 plviartieaANEEPGDKGHLAATEHTENKKGiiVGATVMVLTQIVMVAIMTMTPV-----HMRHHGHDLGAVGLVIGFH 295
Cdd:cd17370 176 ----------VVKEYPRPPKLRKKSKKTSLKK--LPKAFWLYLLAVALFALGNFSFaflilRAQELGLSAALIPLLYALF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 296 IGAMYLPSLVTGVLVDRLGRTAMAISSgtTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATR 375
Cdd:cd17370 244 NLVYALAAYPAGRLSDRIGRKKLLILG--YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 740642681 376 AKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVV 425
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-203 |
1.12e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 47 GAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLsAGFMIGGLGAIGVIMAAIINSIF 126
Cdd:cd17477 201 GFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL-LGCALLGALAALLLPLVPGLPLA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 127 LLFISLLIYGAGTATNLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGPSLV----NVMGDFALSIGVPSLAGPFILA 202
Cdd:cd17477 280 LLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAgalmDAFGPHGLFLFLAAVALLFLLF 359
|
.
gi 740642681 203 A 203
Cdd:cd17477 360 L 360
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
260-423 |
1.53e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 260 MVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGttLLLAGVIAAFAPGD 339
Cdd:cd17477 5 VALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGA--AITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 340 SMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALsGAAGGALSGMIVAGSSYLALSFAGGMLSLL 419
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGL-GFALGPLLLALVGTAGALPFLIAAVLLLLA 161
|
....
gi 740642681 420 LIPV 423
Cdd:cd17477 162 LVPL 165
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
31-175 |
1.74e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 31 LYKRTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAF-AGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFmig 109
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASaAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL--- 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740642681 110 GLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYA-GTDLANHKQRATAVSITMVFTTFGAVA 175
Cdd:COG2814 281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAlVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
36-186 |
1.88e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 40.25 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 36 LFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAIG 115
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740642681 116 VIMAaiiNSIFLLFISLLIYGAGTATNLqARYAGT--DLANHKQRATAvsitMVFTTFGAVAGPSLVNVMGDF 186
Cdd:cd17323 81 CALA---PNIAMLIILRFLQGFFGSSPL-AIGAGTiaDLFTPEERGKA----MGVYSLGPLLGPALGPIIGGF 145
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
72-402 |
2.02e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.95 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 72 GLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMiggLGAIGVIMAAIINSIFLLFISLLIYG-------AGTATNLQ 144
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLL---LSALANIFMGFSTSLWFFAVLWGLNGlfqsmgwPPCVKLLG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 145 ARYAgtdlanHKQRATAVSITMVFTTFGAVAGPSLVnvmgdfALSIGVPSLAGPFILAAAAYMLAGVVLFIMLRPDPlvi 224
Cdd:cd17312 118 NWFS------KKERGTVYGIWSTSHNFGGILAPILA------ASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 225 artieaaneepgdkghlaatehtenkKGIIVGATVMVLTQIVMVAIMTMTPVHMRH-HGHDLGAVGLVIGFHIGAMYLPS 303
Cdd:cd17312 183 --------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGIAGT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 304 LVTGVLVDRLG---RTAMAISSGTTLLLAGVIAAFAPGdSMVLLVIALSLLGLGWnFGLISGTALIVdsTDTATRAKTQG 380
Cdd:cd17312 237 ILAGLLSDKLFggrRAPIAVIYMLLMTLSLALFWFFPH-NKLLSIVLLFLIGFFV-GGPINLIGGAA--AQDIGRKEAAG 312
|
330 340
....*....|....*....|..
gi 740642681 381 TVDVLIALSGAAGGALSGMIVA 402
Cdd:cd17312 313 TATGFVGLFGYLGASLAGLPLG 334
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
23-217 |
2.12e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 23 SSPEKQKSLYKRTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDA-FAGLPSALFTLGSAGSALIVGRLSQRYGRRTG 101
Cdd:cd17473 186 PGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAaLIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 102 LSAGFmigGLGAIGVIMAAIINSIFLLFISLLIYGAG---TATNLQARYAGTDLANHKQRATAVSITMVFttFGAVAGPS 178
Cdd:cd17473 266 LAIGF---ALMALGFLLLALASGLWVVLLGAILAGLGfglLLPTLNSWAMSLVPPELRGRAMGIVTSAFF--LGQFLSPL 340
|
170 180 190
....*....|....*....|....*....|....*....
gi 740642681 179 LVNvmgdfALSIGVPSLAGPFILAAAAYMLAGVVLFIML 217
Cdd:cd17473 341 VLG-----PLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
34-217 |
2.21e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 34 RTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAF-AGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLG 112
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLqAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 113 AIGVIMAAIINSIFLLFISLLIYGAGTATNLQA-RYAGTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDFALSIG 191
Cdd:cd17321 248 LLLLALLGADSSVWLLLPGLVLLGLGLGLFATPlTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSAN 327
|
170 180
....*....|....*....|....*.
gi 740642681 192 VPSLAGPFILAAAAYMLAGVVLFIML 217
Cdd:cd17321 328 LGDSGVAALLSAAAAAFAAGFHLAFL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-177 |
2.69e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 23 SSPEKQKSLYKRTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL 102
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740642681 103 SAGFMIGGLGAIGvimAAIINSIFLLFISLLIYGAGTAT-NLQARYAGTDLANHKQRATAVSITMVFTTFGAVAGP 177
Cdd:COG0477 83 LIGLLLFGLASLL---CGLAPSPELLIAARALQGIGAGGlMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
15-218 |
3.31e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 39.73 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 15 TASLQSYISSPEKQKSLYKRTLFvvsisqifgGAGLAAGVTVGALIAQQMLGTDA-FAGLPSALFTLGSAGSALIVGRLS 93
Cdd:pfam05977 208 RAGLRFTAMSRELRSVLVRAFAF---------GLSASAVWALLPLVARDLLDGDAiFYGILLGAVGVGAILGALSLPRLR 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 94 QRYGRRTGLSAGFMIGGLGAIGVimaAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANH---KQRATAVSITMvftT 170
Cdd:pfam05977 279 ERLGSDRLVLLASVVTALVLLSL---ALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPrwvRGRALAVYQTV---F 352
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 740642681 171 FGAVAGPSLVnvMGDFALSIGVPSLagpfILAAAAYMLAGVVLFIMLR 218
Cdd:pfam05977 353 FGGMAAGSWL--WGAVAEALSVTGA----LLGAAAALLAGAAAGLRFR 394
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
253-427 |
3.59e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.26 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 253 IIVGATVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAIssGTTLLLAGVI 332
Cdd:TIGR00895 19 IILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL--WSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 333 AAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFA 412
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
170
....*....|....*
gi 740642681 413 GGMLSLLLIPVVVWF 427
Cdd:TIGR00895 177 GGIAPLLLLLLLMRF 191
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
36-426 |
3.59e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 36 LFVVSISQIFGGAGLAAGVTVGALIAQQMLG--TDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGA 113
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 114 IGvimAAIINSIFLLFISLLIYGAGTATNLQARYA-GTDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMGDfaLSIGV 192
Cdd:cd17316 81 LL---IGLLPTPILLLVLRFLQGIGIGGEYPGASTyVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIP--LLSGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 193 PSLAGPFILAAaaymLAGVVLFIMLRpdplviartieaaneepgdkghlaatehtenkkGIIVGATVMVLTQIVMVAIMT 272
Cdd:cd17316 156 WGWRILFLIGA----LPALLALLLRR---------------------------------RTLLLILLWFFISFGYYGLTT 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 273 MTPVHMRHHGHDLGAVGLVIGFHIGAMYLPS-LVTGVLVDRLGRTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLL 351
Cdd:cd17316 199 FLPTYLQTVLGLSPATSSLYLLLISLGALVGaLIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFIL 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740642681 352 GLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSGMIVAGSSYLALSFAGGMLSLLLIPVVVW 426
Cdd:cd17316 279 SFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
78-418 |
4.08e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 78 FTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAigvIMAAIINSIFLLFISLLIYGAGTATNLQARYA-GTDLANHK 156
Cdd:cd17321 40 YLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLAS---LLCALAPSLAFLIAARALQGIGAAAIMPASLAlIAATFPGE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 157 QRATAVSITMVFTTFGAVAGPSLVNVMGDFAlsigvpSLAGPFILAAAaymlAGVVLFIMLRPdplviartieaaneepg 236
Cdd:cd17321 117 RRGRALGLWGAVVGIGAALGPLLGGLLLELF------GWRWIFLINVP----IGLVALLLART----------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 237 dkghlaatehtenkkgIIVGATVMVLTQIVMVAIMTMTPVHMRH-HGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLG- 314
Cdd:cd17321 170 ----------------FSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGp 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 315 RTAMAISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAAGG 394
Cdd:cd17321 234 RLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGV 313
|
330 340
....*....|....*....|....
gi 740642681 395 ALSGMIVAGSSYLALSFAGGMLSL 418
Cdd:cd17321 314 ALLGALLTAGLSANLGDSGVAALL 337
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
86-428 |
6.41e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.39 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 86 ALIVGRLSQRYGRRTGLSAGfMIGglGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRATAVSIT 165
Cdd:cd17388 55 APILGALSDRFGRRPVLLLS-LAG--AALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 166 MVFTTFGAVAGPSLVNVMGDFalsigvpSLAGPFILAAA----AYMLAGVVLFIMLRPDPLVIARTIEAANeepgdkghL 241
Cdd:cd17388 132 GAAFGLGFIAGPALGGLLGEI-------SPRAPFLVAAGlnglNFLLGLFVLPESLPPERRRAFRWRRANP--------F 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 242 AATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHM--------RHHGHDLGAVGLVIGFhigamyLPSLVTGVLVDRL 313
Cdd:cd17388 197 GSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTedrfdwspTMVGLSLAVFGLLHAL------FQAFVTGPIAKRL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 314 G-----RTAMAISSGTTLLLagviaAFAPGDSMVLLVIALSLLGlgwNFGLISGTALIVDSTDTATRAKTQGTVDVLIAL 388
Cdd:cd17388 271 GekraiLLGLAADALGFLLL-----AFATQGWMVFPILILLALG---GIAGPALQGLLSRQVPENEQGELQGVLTSLTSL 342
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 740642681 389 SGAAGGALSGMIVAGSSYL---ALSFAGGMLSLLLIPVVVWFR 428
Cdd:cd17388 343 TSIIGPLLFTGIFAASPATwpgLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
71-219 |
6.52e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.34 E-value: 6.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 71 AGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLGAigVIMAAIINSIFLLFISLLIYGAGTATNLQARYA-G 149
Cdd:cd17365 208 ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSL--ALLGVSPASLVLLYVLVFLAGACVNGAQVGLYAlA 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 150 TDLANHKQRATAVSITMVFTTFGAVAGPSLVNVMgdfaLSIGVPSLAGPFILAAAAYMLAGVVLFIMLRP 219
Cdd:cd17365 286 ARFYPTEVRATGVGWALGVGRLGAILGPLLGGLL----LAAGLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
34-140 |
7.06e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 34 RTLFVVSISQIFGGAGLAAGVTVGALIAQQMLGTDAF-AGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMIGGLG 112
Cdd:cd17503 178 RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFeSGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
|
90 100
....*....|....*....|....*...
gi 740642681 113 AIGVIMAAIINSIFLLFISLLIYGAGTA 140
Cdd:cd17503 258 TLLLAFLTPDTSLWLIILPLFIRGLGMG 285
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
89-421 |
7.38e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 7.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 89 VGRLSQRYGRRTG-LSAGFMIGGLGAIGVIMAaiiNSIFLLFISLLIYGAGTAT--NLQARYAGTDLANHKQRATavSIT 165
Cdd:cd17490 51 LGILSDRIGKRKLfIIIGLLFTVLASLIMILF---PSPWGLLIARFLSGIAAATwvSFTVLYASYFPPDEAAKAM--GLI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 166 MVFTTFGAVAGPSlvnVMGDFALSIGVPSlagPFILAAAAYMLAGVVLFIMlrpdplviartieaanEEPGDKGHLAATE 245
Cdd:cd17490 126 NLVNNLGQLIAFL---IGGLIAEHFGMRA---PFLLAALAGVLGFILSLFI----------------KEERREKKPVLTE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 246 HTE------NKKGIIVGATVMVLTQIVMVAIMTMTPVHMRHHGHDLGAVGLVIGFHIGAMYLPSLVTG-VLVDRLGRTAM 318
Cdd:cd17490 184 LKEllsvlkDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNT 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 319 AISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLIsgTALIVDSTDTATRAKTQGTVDVLIALSGAAGGALSG 398
Cdd:cd17490 264 IIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLL--MSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVG 341
|
330 340 350
....*....|....*....|....*....|
gi 740642681 399 MIVAGSSYL-------ALSFAGGMLSLLLI 421
Cdd:cd17490 342 IISEAFGLQtgffvigVIALLAAILSLAYY 371
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
67-405 |
8.76e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 8.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 67 TDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGLSAGFMiggLGAIGVIMAAIINSIFLLFISLLIYGAG------TA 140
Cdd:cd17371 32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITIL---LFAVFTLLCGFAQNYWQLLILRALAGLGfggewaAG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 141 TNLQARYAGTdlanhKQRATAVSITMVFTTFGAVAGPSLVNVMgdFALSIGVPSLAGPFILAAAAymlAGVVLFIMLRPD 220
Cdd:cd17371 109 AALMAEYVPA-----RHRGKALGYVQSGWAVGWLLATLLAALL--FPLLPPEIAWRVLFLLGALP---ALLVLFIRRFVK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 221 PLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPVHMR-HHGHDLGAVGLVIGFHIGAM 299
Cdd:cd17371 179 EPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTgERGLSFEGSAGYLVVTILGG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740642681 300 YLPSLVTGVLVDRLGRTAMaISSGTTLLLAGVIAAFAPGDSMVLLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQ 379
Cdd:cd17371 259 FLGYLAGGFLADRIGRRNN-FALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQ 337
|
330 340
....*....|....*....|....*.
gi 740642681 380 GTVDVLIALSGAAGGALSGMIVAGSS 405
Cdd:cd17371 338 GFCYNVGRIIGALFPFLVGFLATSGS 363
|
|
| |
