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Conserved domains on  [gi|746130254|ref|WP_039195667|]
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3-deoxy-8-phosphooctulonate synthase [Actinobacillus suis]

Protein Classification

3-deoxy-8-phosphooctulonate synthase( domain architecture ID 10012268)

3-deoxy-8-phosphooctulonate synthase catalyzes the condensation reaction between arabinose 5-phosphate and phosphoenolpyruvate to synthesize 3-deoxy-D-manno-octulosonate-8-phosphate (KDO8P), the precursor of the 8-carbon sugar KDO, which is an essential component of gram-negative bacterial lipopolysaccharides

Gene Ontology:  GO:0019294|GO:0008676
SCOP:  4003245

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-274 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


:

Pssm-ID: 235363  Cd Length: 264  Bit Score: 538.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   9 GNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  89 GVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDR 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 169 GTNFGYDNLVVDMLGFNIMKKVskGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAK 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRET--GAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNAL 238

                        250       260
                 ....*....|....*....|....*.
gi 746130254 249 CDGPSALPLSKLEAFVSQMKAIDDLV 274
Cdd:PRK05198 239 SDGPNMLPLDKLEPLLEQLKAIDDLV 264
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-274 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 538.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   9 GNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  89 GVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDR 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 169 GTNFGYDNLVVDMLGFNIMKKVskGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAK 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRET--GAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNAL 238

                        250       260
                 ....*....|....*....|....*.
gi 746130254 249 CDGPSALPLSKLEAFVSQMKAIDDLV 274
Cdd:PRK05198 239 SDGPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 8-274 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 522.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   8 VGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDT 87
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  88 FGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCD 167
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 168 RGTNFGYDNLVVDMLGFNIMKKvsKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSA 247
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRE--TGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKA 238

                        250       260
                 ....*....|....*....|....*..
gi 746130254 248 KCDGPSALPLSKLEAFVSQMKAIDDLV 274
Cdd:COG2877  239 LSDGPNMLPLDKLEELLEQLKAIDELV 265
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 17-276 2.29e-174

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 481.48  E-value: 2.29e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   17 KPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTFGVNIITDV 96
Cdd:TIGR01362   1 EKFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   97 HEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDN 176
Cdd:TIGR01362  81 HESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  177 LVVDMLGFNIMKKVskGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAKCDGPSALP 256
Cdd:TIGR01362 161 LVVDMRSLPIMREL--GCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLP 238

                         250       260
                  ....*....|....*....|
gi 746130254  257 LSKLEAFVSQMKAIDDLVKS 276
Cdd:TIGR01362 239 LSELEGLLEKLLAIDALTKS 258
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 9-276 1.16e-84

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 254.55  E-value: 1.16e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254    9 GNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSsIHSYRGPGMEEGLKIFQELKDTF 88
Cdd:pfam00793   8 QDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTS-PVGFKGLGNDPDLNILFRIKDGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   89 GVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECG-NENVILCD 167
Cdd:pfam00793  87 GLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGvTKGNILCE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  168 RGTNFGY--DNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDpfgaasGGRRDQVTELARSGMAIGLAGLFLEAHPDPN 245
Cdd:pfam00793 167 RGIRGGEgpNRNTLDVSAVAILKEETGHLPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEVHPNPG 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 746130254  246 SAKCDGPSALPLSKLEAFVSQMKAIDDLVKS 276
Cdd:pfam00793 241 NALSDGPQQLKYGKSETDACILWELTELLLE 271
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
2-268 2.39e-30

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 116.29  E-value: 2.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   2 NNKIVKVGNIEVANDKPfTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKAsfdkanRSSIHSYRGPGmEEGLKIF 81
Cdd:NF041229  75 DRSVVRVGGASIGPGTP-TLIAGPCAVETPEQTLRAALMARAAGATVLRGGAFKP------RTSPYAFQGLG-EAGLKIL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  82 QELKDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMArtgaviNVKKPQFLSPGQMGNI------VEKI 155
Cdd:NF041229 147 ADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVG------DVGKPVMLKRGMSGTIeewlmaAEYV 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 156 AECGNENVILCDRG--TNFGYDNLVVDMLGFNIMKKVSKgCPVIFDVTHSlqcrdpfgaasGGRRDQVTELARSGMAIGL 233
Cdd:NF041229 221 AQRGNLDIVLCERGirTFETATRNTLDIAAVPIVQRLSH-LPVIVDPSHS-----------GGRRDLVLPLTRAALAVGA 288

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 746130254 234 AGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMK 268
Cdd:NF041229 289 DGVIVDVHPDPRTALCDGPQALVHEDLEELGAVMR 323
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-274 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 538.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   9 GNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  89 GVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDR 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 169 GTNFGYDNLVVDMLGFNIMKKVskGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAK 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRET--GAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNAL 238

                        250       260
                 ....*....|....*....|....*.
gi 746130254 249 CDGPSALPLSKLEAFVSQMKAIDDLV 274
Cdd:PRK05198 239 SDGPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 8-274 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 522.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   8 VGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDT 87
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  88 FGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCD 167
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 168 RGTNFGYDNLVVDMLGFNIMKKvsKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSA 247
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRE--TGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKA 238

                        250       260
                 ....*....|....*....|....*..
gi 746130254 248 KCDGPSALPLSKLEAFVSQMKAIDDLV 274
Cdd:COG2877  239 LSDGPNMLPLDKLEELLEQLKAIDELV 265
PRK12457 PRK12457
3-deoxy-8-phosphooctulonate synthase;
9-281 0e+00

3-deoxy-8-phosphooctulonate synthase;


Pssm-ID: 237105  Cd Length: 281  Bit Score: 519.30  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   9 GNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTF 88
Cdd:PRK12457   7 PGITVGNDLPFVLFGGINVLESLDFTLDVCGEYVEVTRKLGIPFVFKASFDKANRSSIHSYRGVGLDEGLRIFEEVKARF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  89 GVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDR 168
Cdd:PRK12457  87 GVPVITDVHEVEQAAPVAEVADVLQVPAFLARQTDLVVAIAKTGKPVNIKKPQFMSPTQMKHVVSKCREAGNDRVILCER 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 169 GTNFGYDNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAK 248
Cdd:PRK12457 167 GSSFGYDNLVVDMLGFRQMKRTTGDLPVIFDVTHSLQCRDPLGAASGGRRRQVLDLARAGMAVGLAGLFLEAHPDPDRAR 246

                        250       260       270
                 ....*....|....*....|....*....|...
gi 746130254 249 CDGPSALPLSKLEAFVSQMKAIDDLVKSFEEID 281
Cdd:PRK12457 247 CDGPSALPLDQLEPFLSQVKALDDLVKSFPPLD 279
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 17-276 2.29e-174

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 481.48  E-value: 2.29e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   17 KPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTFGVNIITDV 96
Cdd:TIGR01362   1 EKFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   97 HEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDN 176
Cdd:TIGR01362  81 HESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  177 LVVDMLGFNIMKKVskGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAKCDGPSALP 256
Cdd:TIGR01362 161 LVVDMRSLPIMREL--GCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLP 238

                         250       260
                  ....*....|....*....|
gi 746130254  257 LSKLEAFVSQMKAIDDLVKS 276
Cdd:TIGR01362 239 LSELEGLLEKLLAIDALTKS 258
PLN03033 PLN03033
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 17-275 1.21e-101

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 178601  Cd Length: 290  Bit Score: 298.70  E-value: 1.21e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  17 KPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSSIHSYRGPGMEEGLKIFQELKDTFGVNIITDV 96
Cdd:PLN03033  15 EPFFLLAGPNVIESEEHILRMAKHIKDISTKLGLPLVFKSSFDKANRTSSKSFRGPGMAEGLKILEKVKVAYDLPIVTDV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  97 HEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDN 176
Cdd:PLN03033  95 HESSQCEAVGKVADIIQIPAFLCRQTDLLVAAAKTGKIINIKKGQFCAPSVMRNSAEKVRLAGNPNVMVCERGTMFGYND 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 177 LVVDMLGFNIMKKVskGCPVIFDVTHSLQ-----CRDPFGAASGGRRDQVTELARSGMAIGLAGLFLEAHPDPNSAKCDG 251
Cdd:PLN03033 175 LIVDPRNLEWMREA--NCPVVADITHSLQqpagkKLDGGGVASGGLRELIPCIARTAVAVGVDGIFMEVHDDPLSAPVDG 252

                        250       260
                 ....*....|....*....|....
gi 746130254 252 PSALPLSKLEAFVSQMKAIDDLVK 275
Cdd:PLN03033 253 PTQWPLRHLEELLEELIAIARVTK 276
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 9-276 1.16e-84

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 254.55  E-value: 1.16e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254    9 GNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKASFDKANRSsIHSYRGPGMEEGLKIFQELKDTF 88
Cdd:pfam00793   8 QDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTS-PVGFKGLGNDPDLNILFRIKDGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   89 GVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGAVINVKKPQFLSPGQMGNIVEKIAECG-NENVILCD 167
Cdd:pfam00793  87 GLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGvTKGNILCE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  168 RGTNFGY--DNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDpfgaasGGRRDQVTELARSGMAIGLAGLFLEAHPDPN 245
Cdd:pfam00793 167 RGIRGGEgpNRNTLDVSAVAILKEETGHLPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEVHPNPG 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 746130254  246 SAKCDGPSALPLSKLEAFVSQMKAIDDLVKS 276
Cdd:pfam00793 241 NALSDGPQQLKYGKSETDACILWELTELLLE 271
PRK08673 PRK08673
3-deoxy-7-phosphoheptulonate synthase; Reviewed
 5-275 3.92e-34

3-deoxy-7-phosphoheptulonate synthase; Reviewed


Pssm-ID: 181535 [Multi-domain]  Cd Length: 335  Bit Score: 126.16  E-value: 3.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   5 IVKVGNIEVANDKPFTLFGGMNVlESRDMAMRVCEQYVEVTNKLSVPYVFKAsfdkanRSSIHSYRGPGmEEGLKIFQEL 84
Cdd:PRK08673  81 VVKVGDVEIGGGKPVVIAGPCSV-ESEEQILEIARAVKEAGAQILRGGAFKP------RTSPYSFQGLG-EEGLKLLAEA 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  85 KDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTgavinvKKPQFLSPGqMGNIVEK-------IAE 157
Cdd:PRK08673 153 REETGLPIVTEVMDPRDVELVAEYVDILQIGARNMQNFDLLKEVGKT------NKPVLLKRG-MSATIEEwlmaaeyILA 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 158 CGNENVILCDRG-------TNFGYD-NLVVdmlgfnIMKKVSKgCPVIFDVTHSlqcrdpfgaasGGRRDQVTELARSGM 229
Cdd:PRK08673 226 EGNPNVILCERGirtfetaTRNTLDlSAVP------VIKKLTH-LPVIVDPSHA-----------TGKRDLVEPLALAAV 287

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 746130254 230 AIGLAGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVK 275
Cdd:PRK08673 288 AAGADGLIVEVHPDPEKALSDGPQSLTPEEFEELMKKLRAIAEALG 333
AroGA COG2876
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
 5-274 3.41e-31

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 442123  Cd Length: 283  Bit Score: 117.09  E-value: 3.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   5 IVKVGNIEVANDKpFTLFGGMNVLESRDMAMRVceqyvevtnklsvpyvfkASFDKAN------------RSSIHSYRGP 72
Cdd:COG2876   28 VVDVGGVKIGGGE-LVVIAGPCAVESEEQILET------------------AKAVKAAgakilrggafkpRTSPYSFQGL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  73 GmEEGLKIFQELKDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAflaR--Q-TDLVEAMARTGavinvkKPQFLSPGQMG 149
Cdd:COG2876   89 G-EEGLKLLAEAREETGLPVVTEVMDPRDVELVAEYADILQIGA---RnmQnFELLKEVGRTG------KPVLLKRGLSA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 150 NIV------EKIAECGNENVILCDRG--TnfgYDNLVVDMLGFN---IMKKVSkGCPVIFDVTHSlqcrdpfgaasGGRR 218
Cdd:COG2876  159 TIEewlmaaEYILSEGNPNVILCERGirT---FETATRNTLDLSavpVLKELT-HLPVIVDPSHA-----------TGRR 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 746130254 219 DQVTELARSGMAIGLAGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLV 274
Cdd:COG2876  224 DLVPPMAKAAVAAGADGLMIEVHPDPEKALSDGPQSLTPEEFAELMEELRKLAEAV 279
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
2-268 2.39e-30

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 116.29  E-value: 2.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   2 NNKIVKVGNIEVANDKPfTLFGGMNVLESRDMAMRVCEQYVEVTNKLSVPYVFKAsfdkanRSSIHSYRGPGmEEGLKIF 81
Cdd:NF041229  75 DRSVVRVGGASIGPGTP-TLIAGPCAVETPEQTLRAALMARAAGATVLRGGAFKP------RTSPYAFQGLG-EAGLKIL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  82 QELKDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMArtgaviNVKKPQFLSPGQMGNI------VEKI 155
Cdd:NF041229 147 ADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVG------DVGKPVMLKRGMSGTIeewlmaAEYV 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 156 AECGNENVILCDRG--TNFGYDNLVVDMLGFNIMKKVSKgCPVIFDVTHSlqcrdpfgaasGGRRDQVTELARSGMAIGL 233
Cdd:NF041229 221 AQRGNLDIVLCERGirTFETATRNTLDIAAVPIVQRLSH-LPVIVDPSHS-----------GGRRDLVLPLTRAALAVGA 288

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 746130254 234 AGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMK 268
Cdd:NF041229 289 DGVIVDVHPDPRTALCDGPQALVHEDLEELGAVMR 323
PRK12595 PRK12595
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed
 3-276 2.64e-24

bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed


Pssm-ID: 183614 [Multi-domain]  Cd Length: 360  Bit Score: 100.44  E-value: 2.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254   3 NKIVKVGNIEVANDKPFTLFGGMNVlESRDMAMRVCEQYVEVTNKLSVPYVFKAsfdkanRSSIHSYRGPGmEEGLKIFQ 82
Cdd:PRK12595 104 DTIVDVKGEVIGDGNQSFIFGPCSV-ESYEQVEAVAKALKAKGLKLLRGGAFKP------RTSPYDFQGLG-VEGLKILK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  83 ELKDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTgavinvKKPQFLSPGQMGNI------VEKIA 156
Cdd:PRK12595 176 QVADEYGLAVISEIVNPADVEVALDYVDVIQIGARNMQNFELLKAAGRV------NKPVLLKRGLSATIeefiyaAEYIM 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 157 ECGNENVILCDRG--TNFGYDNLVVDMLGFNIMKKVSKgCPVIFDVTHSLqcrdpfgaasgGRRDQVTELARSGMAIGLA 234
Cdd:PRK12595 250 SQGNGQIILCERGirTYEKATRNTLDISAVPILKQETH-LPVMVDVTHST-----------GRRDLLLPTAKAALAIGAD 317

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 746130254 235 GLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKS 276
Cdd:PRK12595 318 GVMAEVHPDPAVALSDSAQQMDIPEFDRFLDELKPLANKLNA 359
PRK13396 PRK13396
3-deoxy-7-phosphoheptulonate synthase; Provisional
 63-275 1.28e-16

3-deoxy-7-phosphoheptulonate synthase; Provisional


Pssm-ID: 237376 [Multi-domain]  Cd Length: 352  Bit Score: 78.65  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254  63 RSSIHSYRGPGmEEGLKIFQELKDTFGVNIITDVHEIYQCKPVAEVVDIIQLPAflaRQTDLVEAMARTGAVinvKKPQF 142
Cdd:PRK13396 140 RTSPYAFQGHG-ESALELLAAAREATGLGIITEVMDAADLEKIAEVADVIQVGA---RNMQNFSLLKKVGAQ---DKPVL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746130254 143 LSPGQMGNI------VEKIAECGNENVILCDRGTNFGYDNLVVDMLGFNIMkkvskgcPVIFDVTHSLQCRDPfgAASGG 216
Cdd:PRK13396 213 LKRGMAATIdewlmaAEYILAAGNPNVILCERGIRTFDRQYTRNTLDLSVI-------PVLRSLTHLPIMIDP--SHGTG 283

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 746130254 217 RRDQVTELARSGMAIGLAGLFLEAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVK 275
Cdd:PRK13396 284 KSEYVPSMAMAAIAAGTDSLMIEVHPNPAKALSDGPQSLTPDRFDRLMQELAVIGKTVG 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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