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Conserved domains on  [gi|748693062|ref|WP_039951184|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Rhodococcus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11461403)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  15808743|23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
3-207 1.26e-20

DNA-binding transcriptional regulator YbjK [Transcription];


:

Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 84.99  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062   3 RLPADVRRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQSLILDVSEAMRAAFSQLLGPl 82
Cdd:COG3226    3 RRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDL- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  83 tLRGVPALRELLGSGIRglwpiieATPDQQLLTYEITAQALRQRGagndsAGAIAARQYRtmdteavAFLGLCAHRAGVT 162
Cdd:COG3226   82 -EDAAEALADLLAELLP-------ADRDRLLARYELYLEALRDPE-----LRALLRRWRD-------RLREALARLLAAL 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 748693062 163 WGTPVDQVARFALAVLDGVVLRWLVDRDSDAALTALDDLVQIIAA 207
Cdd:COG3226  142 GSPDPPETARALVALIDGLTLHALLDPDPLTREELRAALRRLLRA 186
 
Name Accession Description Interval E-value
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
3-207 1.26e-20

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 84.99  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062   3 RLPADVRRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQSLILDVSEAMRAAFSQLLGPl 82
Cdd:COG3226    3 RRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDL- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  83 tLRGVPALRELLGSGIRglwpiieATPDQQLLTYEITAQALRQRGagndsAGAIAARQYRtmdteavAFLGLCAHRAGVT 162
Cdd:COG3226   82 -EDAAEALADLLAELLP-------ADRDRLLARYELYLEALRDPE-----LRALLRRWRD-------RLREALARLLAAL 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 748693062 163 WGTPVDQVARFALAVLDGVVLRWLVDRDSDAALTALDDLVQIIAA 207
Cdd:COG3226  142 GSPDPPETARALVALIDGLTLHALLDPDPLTREELRAALRRLLRA 186
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 10-61 9.47e-11

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 58.98  E-value: 9.47e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 748693062  10 RGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQ 61
Cdd:PRK09975  13 RQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWL 64
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 1.95e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 51.64  E-value: 1.95e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 748693062   13 LIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEM 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
10-93 1.91e-05

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 43.74  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  10 RGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEmgqslildVSEAMRAAFSQLLGPLTLRGVPA 89
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARA--------VLEEQVARLREAVEPQRAGGGSK 79


                 ....
gi 748693062  90 LREL 93
Cdd:NF041196  80 LQEL 83
 
Name Accession Description Interval E-value
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
3-207 1.26e-20

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 84.99  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062   3 RLPADVRRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQSLILDVSEAMRAAFSQLLGPl 82
Cdd:COG3226    3 RRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDL- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  83 tLRGVPALRELLGSGIRglwpiieATPDQQLLTYEITAQALRQRGagndsAGAIAARQYRtmdteavAFLGLCAHRAGVT 162
Cdd:COG3226   82 -EDAAEALADLLAELLP-------ADRDRLLARYELYLEALRDPE-----LRALLRRWRD-------RLREALARLLAAL 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 748693062 163 WGTPVDQVARFALAVLDGVVLRWLVDRDSDAALTALDDLVQIIAA 207
Cdd:COG3226  142 GSPDPPETARALVALIDGLTLHALLDPDPLTREELRAALRRLLRA 186
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
3-180 9.49e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 60.68  E-value: 9.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062   3 RLPADVRRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQSLILDVSEAMRAAFSQllgpl 82
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAA----- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  83 tlrgvPALRELLGSGIRGLWPIIEATPDQQLLTYEITAQAlrqrgagndsagAIAARQYRTMDTEAVAFLGLCAHRAGVT 162
Cdd:COG1309   76 -----EDPRERLRALLRAYLEFLAENPALARLLLAEAAEL------------PELRAALRALLRRLRALLAELLRAGGLL 138

                        170
                 ....*....|....*...
gi 748693062 163 WGTPVDQVARFALAVLDG 180
Cdd:COG1309  139 ADVDPDALARALLALLDG 156
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 10-61 9.47e-11

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 58.98  E-value: 9.47e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 748693062  10 RGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQ 61
Cdd:PRK09975  13 RQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWL 64
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 1.95e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 51.64  E-value: 1.95e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 748693062   13 LIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEM 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 8-74 4.68e-09

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 54.08  E-value: 4.68e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748693062   8 VRRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQSLILDVSEAMRAA 74
Cdd:PRK00767   9 IRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGDAVLAR 75
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 10-94 1.94e-08

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 52.70  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  10 RGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTE---MGQSLILDVSEAMRAAFSQllGPLTLrg 86
Cdd:PRK10668  13 RQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEiweLSESKIGELELEYQAKFPD--DPLSV-- 88


                 ....*...
gi 748693062  87 vpaLRELL 94
Cdd:PRK10668  89 ---LREIL 93
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 1-55 2.44e-07

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 49.32  E-value: 2.44e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 748693062   1 MQRLPADVRRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEEL 55
Cdd:PRK14996   1 MSYLNRDERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSAGEL 55
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
10-93 1.91e-05

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 43.74  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748693062  10 RGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEmgqslildVSEAMRAAFSQLLGPLTLRGVPA 89
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARA--------VLEEQVARLREAVEPQRAGGGSK 79


                 ....
gi 748693062  90 LREL 93
Cdd:NF041196  80 LQEL 83
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 9-82 9.87e-04

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 38.76  E-value: 9.87e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748693062   9 RRGQLIDAALAITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEELLTEMGQSlILDVSEAMRAAFSQLLGPL 82
Cdd:PRK15008  19 KKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQ-ILDIWLAPLKAFREDFAPL 91
PRK11202 PRK11202
HTH-type transcriptional repressor FabR;
10-55 1.44e-03

HTH-type transcriptional repressor FabR;


Pssm-ID: 236881 [Multi-domain]  Cd Length: 203  Bit Score: 38.45  E-value: 1.44e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 748693062  10 RGQLIDAALA-ITAQHGVAALTVRGVAEAAGVSLGVVHYHFEDKEEL 55
Cdd:PRK11202  13 RRALIDAAFSqLSAERSFSSLSLREVAREAGIAPTSFYRHFRDMDEL 59
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 10-55 1.46e-03

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 38.49  E-value: 1.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 748693062  10 RGQLIDAALAITAQHGVAAlTVRGVAEAAGVSLGVVHYHFEDKEEL 55
Cdd:PRK11552  15 KQQLIAAALAQFGEYGLHA-TTRDIAAQAGQNIAAITYYFGSKEDL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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