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Conserved domains on  [gi|758868254|ref|WP_043030279|]
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helix-turn-helix domain-containing protein [Streptococcus equi]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11444431)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-69 2.71e-15

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 69.45  E-value: 2.71e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758868254   1 MRETSLGELLRETRVGKNITLDEIEAKTGISSHYLLAMELDQFKIIPEEKFGH-FLKQYADIVGLDFDSL 69
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRgFLRSYARALGLDPEEL 70
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-69 2.71e-15

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 69.45  E-value: 2.71e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758868254   1 MRETSLGELLRETRVGKNITLDEIEAKTGISSHYLLAMELDQFKIIPEEKFGH-FLKQYADIVGLDFDSL 69
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRgFLRSYARALGLDPEEL 70
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 9-69 1.78e-14

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 67.13  E-value: 1.78e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 758868254    9 LLRETRVGKNITLDEIEAKTGISSHYLLAMELDQFKIIPEEKFGH-FLKQYADIVGLDFDSL 69
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARgFLRSYARALGLDPEEL 62
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-69 2.71e-15

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 69.45  E-value: 2.71e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758868254   1 MRETSLGELLRETRVGKNITLDEIEAKTGISSHYLLAMELDQFKIIPEEKFGH-FLKQYADIVGLDFDSL 69
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRgFLRSYARALGLDPEEL 70
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 9-69 1.78e-14

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 67.13  E-value: 1.78e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 758868254    9 LLRETRVGKNITLDEIEAKTGISSHYLLAMELDQFKIIPEEKFGH-FLKQYADIVGLDFDSL 69
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARgFLRSYARALGLDPEEL 62
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 7-75 6.84e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 48.82  E-value: 6.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 758868254    7 GELLRETRVGKNITLDEIEAKTGISSHYLLAMELDQFKIIPEEkfghfLKQYADIVGLDFDSLKRLYQL 75
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAET-----LYKIAELLGVPANWLLQGEGE 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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